Med6

Summary

Gene Symbol: Med6
Description: mediator complex subunit 6
Alias: 1500012F11Rik, AU019660, AV213303, mediator of RNA polymerase II transcription subunit 6, mediator of RNA polymerase II transcription, subunit 6 homolog
Species: mouse

Top Publications

  1. ncbi PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator
    Rushad Pavri
    Department of Biochemistry, Howard Hughes Medical Institute, University of Medicine and Dentistry of New Jersey, 683 Hoes Lane, Piscataway, New Jersey 08854, USA
    Mol Cell 18:83-96. 2005
  2. pmc MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis
    Beatriz Aranda-Orgilles
    Department of Pathology, Laura and Isaac Perlmutter Cancer Center, and The Helen L and Martin S Kimmel Center for Stem Cell Biology, NYU School of Medicine, New York, NY 10016, USA
    Cell Stem Cell 19:784-799. 2016
  3. pmc Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways
    Y W Jiang
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 95:8538-43. 1998
  4. pmc Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors
    Sohail Malik
    Laboratory of Biochemistry and Molecular Biology, Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    Mol Cell Biol 24:8244-54. 2004
  5. pmc Mediator and cohesin connect gene expression and chromatin architecture
    Michael H Kagey
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 467:430-5. 2010

Detail Information

Publications5

  1. ncbi PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator
    Rushad Pavri
    Department of Biochemistry, Howard Hughes Medical Institute, University of Medicine and Dentistry of New Jersey, 683 Hoes Lane, Piscataway, New Jersey 08854, USA
    Mol Cell 18:83-96. 2005
    ..PARP-1 appears to function as a specificity factor regulating the RA-induced switch of Mediator from the inactive (Cdk8+) to the active (Cdk8-) state in RAR-dependent transcription...
  2. pmc MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis
    Beatriz Aranda-Orgilles
    Department of Pathology, Laura and Isaac Perlmutter Cancer Center, and The Helen L and Martin S Kimmel Center for Stem Cell Biology, NYU School of Medicine, New York, NY 10016, USA
    Cell Stem Cell 19:784-799. 2016
    ..As MED12 mutations have been described recently in blood malignancies, alterations in MED12-dependent enhancer regulation may control both physiological and malignant hematopoiesis...
  3. pmc Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways
    Y W Jiang
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 95:8538-43. 1998
    ..with the complex; peptide sequencing reveals, in addition, homologs of the yeast Mediator subunits Rgr1 and Med6; as with yeast Mediator, the mouse complex binds to the RNA polymerase II C-terminal domain (CTD) and stimulates ..
  4. pmc Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors
    Sohail Malik
    Laboratory of Biochemistry and Molecular Biology, Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    Mol Cell Biol 24:8244-54. 2004
    ..The implications of these observations are discussed in terms of our present understanding of coactivator function...
  5. pmc Mediator and cohesin connect gene expression and chromatin architecture
    Michael H Kagey
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 467:430-5. 2010
    ..Mediator and cohesin co-occupy different promoters in different cells, thus generating cell-type-specific DNA loops linked to the gene expression program of each cell...