Med30

Summary

Gene Symbol: Med30
Description: mediator complex subunit 30
Alias: 1810038N03Rik, 2510044J04Rik, TRAP25, Thrap6, mediator of RNA polymerase II transcription subunit 30, TRAP/Mediator complex component TRAP25, thyroid hormone receptor associated protein 6, thyroid hormone receptor-associated protein complex 25 kDa component
Species: mouse

Top Publications

  1. pmc Subunit architecture and functional modular rearrangements of the transcriptional mediator complex
    Kuang Lei Tsai
    Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell 157:1430-44. 2014
  2. pmc MED30 Regulates the Proliferation and Motility of Gastric Cancer Cells
    Yong Joo Lee
    Department of Anatomy, School of Medicine, Pusan National University, Busan, Republic of Korea
    PLoS ONE 10:e0130826. 2015
  3. pmc Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet
    Philippe Krebs
    Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 108:19678-82. 2011
  4. pmc Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors
    Sohail Malik
    Laboratory of Biochemistry and Molecular Biology, Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    Mol Cell Biol 24:8244-54. 2004
  5. pmc Mediator and cohesin connect gene expression and chromatin architecture
    Michael H Kagey
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 467:430-5. 2010

Detail Information

Publications5

  1. pmc Subunit architecture and functional modular rearrangements of the transcriptional mediator complex
    Kuang Lei Tsai
    Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell 157:1430-44. 2014
    ..Conservation across eukaryotes of Mediator structure, subunit organization, and RNA polymerase II interaction suggest conservation of fundamental aspects of the Mediator mechanism. ..
  2. pmc MED30 Regulates the Proliferation and Motility of Gastric Cancer Cells
    Yong Joo Lee
    Department of Anatomy, School of Medicine, Pusan National University, Busan, Republic of Korea
    PLoS ONE 10:e0130826. 2015
    b>MED30 is an essential member of the mediator complex that forms a hub between transcriptional activators and RNA polymerase II. However, the expressions and roles of MED30 have been poorly characterized in cancer...
  3. pmc Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet
    Philippe Krebs
    Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 108:19678-82. 2011
    ..Here we describe a missense mutation in Med30 causing progressive cardiomyopathy in homozygous mice that, although viable during lactation, show precipitous ..
  4. pmc Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors
    Sohail Malik
    Laboratory of Biochemistry and Molecular Biology, Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    Mol Cell Biol 24:8244-54. 2004
    ..The implications of these observations are discussed in terms of our present understanding of coactivator function...
  5. pmc Mediator and cohesin connect gene expression and chromatin architecture
    Michael H Kagey
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 467:430-5. 2010
    ..Mediator and cohesin co-occupy different promoters in different cells, thus generating cell-type-specific DNA loops linked to the gene expression program of each cell...