Genomes and Genes
Gene Symbol: Med17
Description: mediator complex subunit 17
Alias: 77kDa, C330002H14Rik, Crsp6, Trap80, CRSP complex subunit 6, cofactor required for Sp1 transcriptional activation subunit 6, cofactor required for Sp1 transcriptional activation, subunit 6 (77kD), mediator of RNA polymerase II transcription subunit 17, thyroid hormone receptor-associated protein complex 80 kDa component
- Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesisKai Ge
Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
Nature 417:563-7. 2002..These data indicate that TRAP220 acts, via the TRAP complex, as a PPAR gamma(2)-selective coactivator and, accordingly, that it is specific for one fibroblast differentiation pathway (adipogenesis) relative to another (myogenesis)...
- Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptorsSohail Malik
Laboratory of Biochemistry and Molecular Biology, Rockefeller University, 1230 York Ave, New York, NY 10021, USA
Mol Cell Biol 24:8244-54. 2004..The implications of these observations are discussed in terms of our present understanding of coactivator function...
- Two modes of transcriptional activation at native promoters by NF-kappaB p65Dominic van Essen
Max Planck Institute for Immunobiology, Freiburg, Germany
PLoS Biol 7:e73. 2009..This mode enables a subset of promoters to utilize a wide choice of transcription factors, with the potential to regulate their expression accordingly, whilst remaining dependent for their activation on NF-kappaB...
- Mediator and cohesin connect gene expression and chromatin architectureMichael H Kagey
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Nature 467:430-5. 2010..Mediator and cohesin co-occupy different promoters in different cells, thus generating cell-type-specific DNA loops linked to the gene expression program of each cell...