Med17

Summary

Gene Symbol: Med17
Description: mediator complex subunit 17
Alias: 77kDa, C330002H14Rik, Crsp6, Trap80, CRSP complex subunit 6, cofactor required for Sp1 transcriptional activation subunit 6, cofactor required for Sp1 transcriptional activation, subunit 6 (77kD), mediator of RNA polymerase II transcription subunit 17, thyroid hormone receptor-associated protein complex 80 kDa component
Species: mouse

Top Publications

  1. ncbi Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis
    Kai Ge
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 417:563-7. 2002
  2. pmc Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors
    Sohail Malik
    Laboratory of Biochemistry and Molecular Biology, Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    Mol Cell Biol 24:8244-54. 2004
  3. pmc Two modes of transcriptional activation at native promoters by NF-kappaB p65
    Dominic van Essen
    Max Planck Institute for Immunobiology, Freiburg, Germany
    PLoS Biol 7:e73. 2009
  4. pmc Mediator and cohesin connect gene expression and chromatin architecture
    Michael H Kagey
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 467:430-5. 2010

Detail Information

Publications4

  1. ncbi Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis
    Kai Ge
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 417:563-7. 2002
    ..These data indicate that TRAP220 acts, via the TRAP complex, as a PPAR gamma(2)-selective coactivator and, accordingly, that it is specific for one fibroblast differentiation pathway (adipogenesis) relative to another (myogenesis)...
  2. pmc Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors
    Sohail Malik
    Laboratory of Biochemistry and Molecular Biology, Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    Mol Cell Biol 24:8244-54. 2004
    ..The implications of these observations are discussed in terms of our present understanding of coactivator function...
  3. pmc Two modes of transcriptional activation at native promoters by NF-kappaB p65
    Dominic van Essen
    Max Planck Institute for Immunobiology, Freiburg, Germany
    PLoS Biol 7:e73. 2009
    ..This mode enables a subset of promoters to utilize a wide choice of transcription factors, with the potential to regulate their expression accordingly, whilst remaining dependent for their activation on NF-kappaB...
  4. pmc Mediator and cohesin connect gene expression and chromatin architecture
    Michael H Kagey
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 467:430-5. 2010
    ..Mediator and cohesin co-occupy different promoters in different cells, thus generating cell-type-specific DNA loops linked to the gene expression program of each cell...