Med14

Summary

Gene Symbol: Med14
Description: mediator complex subunit 14
Alias: 9930001L01Rik, AU041628, Crsp2, ENSMUSG00000073278, Gm641, ORF1, Trap170, CRSP complex subunit 2, cofactor required for Sp1 transcriptional activation subunit 2 (150 kDa), cofactor required for Sp1 transcriptional activation, subunit 2, mediator of RNA polymerase II transcription subunit 14, thyroid hormone receptor-associated protein complex 170 kDa component
Species: mouse

Top Publications

  1. ncbi Detection and cloning of an X-linked locus associated with a NotI site that is not methylated on mouse inactivated X chromosome by the RLGS-M method
    S Takada
    Graduate School of Environmental Earth Science, Hokkaido University, North 10 West 5 Kita ku, Sapporo, 060 0810, Japan
    Genomics 61:92-100. 1999
  2. ncbi Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis
    Kai Ge
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 417:563-7. 2002
  3. pmc Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors
    Sohail Malik
    Laboratory of Biochemistry and Molecular Biology, Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    Mol Cell Biol 24:8244-54. 2004
  4. pmc MED14 tethers mediator to the N-terminal domain of peroxisome proliferator-activated receptor gamma and is required for full transcriptional activity and adipogenesis
    Lars Grøntved
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark
    Mol Cell Biol 30:2155-69. 2010
  5. pmc Mediator and cohesin connect gene expression and chromatin architecture
    Michael H Kagey
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 467:430-5. 2010

Detail Information

Publications5

  1. ncbi Detection and cloning of an X-linked locus associated with a NotI site that is not methylated on mouse inactivated X chromosome by the RLGS-M method
    S Takada
    Graduate School of Environmental Earth Science, Hokkaido University, North 10 West 5 Kita ku, Sapporo, 060 0810, Japan
    Genomics 61:92-100. 1999
    ..We detected and cloned a candidate locus and identified the Orf1 gene...
  2. ncbi Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis
    Kai Ge
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 417:563-7. 2002
    ..These data indicate that TRAP220 acts, via the TRAP complex, as a PPAR gamma(2)-selective coactivator and, accordingly, that it is specific for one fibroblast differentiation pathway (adipogenesis) relative to another (myogenesis)...
  3. pmc Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors
    Sohail Malik
    Laboratory of Biochemistry and Molecular Biology, Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    Mol Cell Biol 24:8244-54. 2004
    ..The implications of these observations are discussed in terms of our present understanding of coactivator function...
  4. pmc MED14 tethers mediator to the N-terminal domain of peroxisome proliferator-activated receptor gamma and is required for full transcriptional activity and adipogenesis
    Lars Grøntved
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark
    Mol Cell Biol 30:2155-69. 2010
    ..Using a small interfering RNA (siRNA)-based approach, we identify MED14 as a novel critical Mediator component for PPARgamma-dependent transactivation, and we demonstrate that MED14 ..
  5. pmc Mediator and cohesin connect gene expression and chromatin architecture
    Michael H Kagey
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 467:430-5. 2010
    ..Mediator and cohesin co-occupy different promoters in different cells, thus generating cell-type-specific DNA loops linked to the gene expression program of each cell...