Mbp

Summary

Gene Symbol: Mbp
Description: myelin basic protein
Alias: C76307, Hmbpr, R75289, golli-mbp, jve, mld, shi, myelin basic protein, Golli-Mbp, myelin A1 protein, myelin deficient, shiverer
Species: mouse

Top Publications

  1. ncbi Coronin 3 and its role in murine brain morphogenesis
    Andreas Hasse
    Center for Biochemistry and Center of Molecular Medicine Cologne, Medical Faculty, University of Cologne, Joseph Stelzmann Strasse 52, D 50931 Koeln, Germany
    Eur J Neurosci 21:1155-68. 2005
  2. ncbi Changes in microtubule stability and density in myelin-deficient shiverer mouse CNS axons
    L L Kirkpatrick
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Neurosci 21:2288-97. 2001
  3. ncbi Immunochemical studies of myelin basic protein in shiverer mouse devoid of major dense line of myelin
    P Dupouey
    Neurosci Lett 12:113-8. 1979
  4. ncbi Absence of the major dense line in myelin of the mutant mouse "shiverer"
    A Privat
    Neurosci Lett 12:107-12. 1979
  5. ncbi Radial component of CNS myelin: junctional subunit structure and supramolecular assembly
    B Kosaras
    Neurology Research, Children s Hospital, Boston, MA 02115
    J Neurocytol 19:187-99. 1990
  6. pmc Recombination within the myelin basic protein gene created the dysmyelinating shiverer mouse mutation
    S M Molineaux
    Proc Natl Acad Sci U S A 83:7542-6. 1986
  7. ncbi Molecular genetic analysis of myelin-deficient mice: shiverer mutant mice show deletion in gene(s) coding for myelin basic protein
    M Kimura
    J Neurochem 44:692-6. 1985
  8. ncbi The effect of the shiverer mutation on myelin basic protein expression in homozygous and heterozygous mouse brain
    E Barbarese
    J Neurochem 40:1680-6. 1983
  9. ncbi High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice
    J J Lafaille
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Cell 78:399-408. 1994
  10. ncbi Cytoskeleton in myelin-basic-protein-deficient shiverer oligodendrocytes
    C A Dyer
    Department of Biomedical Sciences, E K Shriver Center, Waltham, Mass 02254, USA
    Dev Neurosci 17:53-62. 1995

Research Grants

  1. PROTEIN SYNTHESIS INITIATION IN ANIMAL CELLS
    Bansidhar Datta; Fiscal Year: 2002
  2. GENETIC ELEMENTS REGULATING MYELIN GENE EXPRESSION
    Anthony Campagnoni; Fiscal Year: 2001
  3. Protective Effect of Pregnancy Doses of Estrogens in EAE
    Rhonda Voskuhl; Fiscal Year: 2005
  4. NO DAMAGE TO FOLATE CYCLE IN THE CENTRAL NERVOUS SYSTEM
    Kenneth Hensley; Fiscal Year: 2005
  5. Golli-MBP Gene Expression in the Nervous System
    Anthony Campagnoni; Fiscal Year: 2007
  6. Sex Chromosome Effects in Lupus
    Rhonda Voskuhl; Fiscal Year: 2008
  7. The Effect of Sex Chromosomes on Immune Responses
    Rhonda Voskuhl; Fiscal Year: 2009
  8. Synthesis and Assembly of Basic Proteins into Myelin.
    Anthony Campagnoni; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications122 found, 100 shown here

  1. ncbi Coronin 3 and its role in murine brain morphogenesis
    Andreas Hasse
    Center for Biochemistry and Center of Molecular Medicine Cologne, Medical Faculty, University of Cologne, Joseph Stelzmann Strasse 52, D 50931 Koeln, Germany
    Eur J Neurosci 21:1155-68. 2005
    ..Full-length coronin 3 among other areas localized to outgrowing neurites, whereas truncated proteins efficiently suppressed neurite formation. Our results favour a role for coronin 3 in neuron morphogenesis and possibly migration...
  2. ncbi Changes in microtubule stability and density in myelin-deficient shiverer mouse CNS axons
    L L Kirkpatrick
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Neurosci 21:2288-97. 2001
    ..The genetic defect in shiverer is a deletion in the myelin basic protein (MBP) gene, an essential component of CNS myelin...
  3. ncbi Immunochemical studies of myelin basic protein in shiverer mouse devoid of major dense line of myelin
    P Dupouey
    Neurosci Lett 12:113-8. 1979
    The myelin-deficient mutant Shiverer (Shi/Shi) lacks basic protein (MBP) in the myelin of its central nervous system (CNS)...
  4. ncbi Absence of the major dense line in myelin of the mutant mouse "shiverer"
    A Privat
    Neurosci Lett 12:107-12. 1979
    The myelin of the central nervous system (CNS) of the mutant mouse Shiverer is characterized by the absence of the major dense line (MDL)...
  5. ncbi Radial component of CNS myelin: junctional subunit structure and supramolecular assembly
    B Kosaras
    Neurology Research, Children s Hospital, Boston, MA 02115
    J Neurocytol 19:187-99. 1990
    ..g., shiverer, transgenic shiverer, myelin deficient and jimpy mutant mice); isolated CNS myelin, which has been shown by X-ray diffraction to be more stable than ..
  6. pmc Recombination within the myelin basic protein gene created the dysmyelinating shiverer mouse mutation
    S M Molineaux
    Proc Natl Acad Sci U S A 83:7542-6. 1986
    ..While small amounts of other myelin components are present in the brain of the shi mouse, the four forms of myelin basic protein (MBP) are not detectable...
  7. ncbi Molecular genetic analysis of myelin-deficient mice: shiverer mutant mice show deletion in gene(s) coding for myelin basic protein
    M Kimura
    J Neurochem 44:692-6. 1985
    The gene expression of myelin basic proteins (MBPs) in shiverer mutant mice was investigated by the Northern and Southern hybridization techniques...
  8. ncbi The effect of the shiverer mutation on myelin basic protein expression in homozygous and heterozygous mouse brain
    E Barbarese
    J Neurochem 40:1680-6. 1983
    We report (a) that the shiverer mutation has pleiotropic phenotypic effects on myelin basic protein expression in the CNS of homozygous (shi/shi) mice and (b) that each of the effects of the shiverer allele is expressed co-dominantly with ..
  9. ncbi High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice
    J J Lafaille
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Cell 78:399-408. 1994
    We have generated TCR transgenic mice (T/R+) specific for myelin basic protein (MBP) and crossed them to RAG-1-deficient mice to obtain mice (T/R-) that have T cells expressing the transgenic TCR but no other lymphocytes...
  10. ncbi Cytoskeleton in myelin-basic-protein-deficient shiverer oligodendrocytes
    C A Dyer
    Department of Biomedical Sciences, E K Shriver Center, Waltham, Mass 02254, USA
    Dev Neurosci 17:53-62. 1995
    ..Here we use the shiverer mutant mouse, which is missing a large segment of the myelin basic protein (MBP) gene, to investigate the possible role in cytoskeletal assembly of an MBP gene product or of other ..
  11. ncbi Neurological mouse mutants and the genes of myelin
    K A Nave
    Zentrum fur Molekulare Biologie, Universitat Heidelberg, Germany
    J Neurosci Res 38:607-12. 1994
    ..b>Shiverer, jimpy, Trembler, and protein zero (P0)-deficient mice demonstrate the overall function of myelination and have ..
  12. ncbi Krox-20 controls myelination in the peripheral nervous system
    P Topilko
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, Paris, France
    Nature 371:796-9. 1994
    ..myelin-associated glycoprotein, late myelin gene products are absent, including those for protein zero and myelin basic protein. Therefore Krox-20 is likely to control a set of genes required for completion of myelination in the ..
  13. ncbi Generation and analysis of normal and shiverer temperature-sensitive immortalized cell lines exhibiting phenotypic characteristics of oligodendrocytes at several stages of differentiation
    L M Foster
    Mental Retardation Research Center, UCLA School of Medicine 90024
    Dev Neurosci 15:100-9. 1993
    ..normal mice and 9 derived from the neurological mutant shiverer, which is missing a large segment of the myelin basic protein gene...
  14. ncbi Conditionally immortalized oligodendrocyte cell lines migrate to different brain regions and elaborate 'myelin-like' membranes after transplantation into neonatal shiverer mouse brains
    L M Foster
    Mental Retardation Research Center, UCLA School of Medicine 90024, USA
    Dev Neurosci 17:160-70. 1995
    ..lines, representing a spectrum of different stages of oligodendrocyte maturation, were transplanted into neonatal shiverer mouse brains and examined for their ability to survive, multiply, and migrate in vivo...
  15. ncbi The POU factor Oct-6 and Schwann cell differentiation
    M Jaegle
    Medical Genetics Center, Department of Cell Biology and Genetics, Erasmus University, Post Office Box 1738, 3000 DR Rotterdam, Netherlands
    Science 273:507-10. 1996
    ..Thus, Oct-6 appears to be required for the transition of promyelin cells to myelinating cells. Once these cells progress past this point, Oct-6 is no longer required, and myelination occurs normally...
  16. ncbi Assembly of CNS myelin in the absence of proteolipid protein
    M Klugmann
    Zentrum für Molekulare Biologie ZMBH University of Heidelburg, Federal Republic of Germany
    Neuron 18:59-70. 1997
    ..Dysmyelination and oligodendrocyte death emerge as an epiphenomenon of other PLP mutations and have been uncoupled in the PLP null allele from the risk of premature myelin breakdown...
  17. ncbi Axonal swellings and degeneration in mice lacking the major proteolipid of myelin
    I Griffiths
    Applied Neurobiology Group, Department of Veterinary Clinical Studies, University of Glasgow, Glasgow G61 1QH, Scotland, UK
    Science 280:1610-3. 1998
    ..Similar swellings were absent in dysmyelinated shiverer mice, which lack myelin basic protein (MBP), but recurred in MBP*PLP double mutants...
  18. ncbi Oligodendrocyte population dynamics and the role of PDGF in vivo
    A R Calver
    MRC Laboratory for Molecular Cell Biology and Department of Biology, University College London, United Kingdom
    Neuron 20:869-82. 1998
    ..Therefore, cell survival controls override proliferation controls for determining the final number and distribution of mature oligodendrocytes...
  19. ncbi Cutting edge: myelin basic protein-specific cytotoxic T cell tolerance is maintained in vivo by a single dominant epitope in H-2k mice
    E S Huseby
    Department of Immunology, University of Washington, Seattle 98195, USA
    J Immunol 163:1115-8. 1999
    ..We demonstrate here that myelin basic protein (MBP) is processed in vivo by the MHC class I pathway leading to a MBP79-87/Kk complex...
  20. ncbi Loss of p27Kip1 function results in increased proliferative capacity of oligodendrocyte progenitors but unaltered timing of differentiation
    P Casaccia-Bonnefil
    Molecular Neurobiology, Skirball Institute for Biomolecular Medicine at NYU Medical Center, New York, NY 10016, USA nyu edu
    Development 126:4027-37. 1999
    ..QKI) to identify embryonic glial progenitors, NG2 to identify neonatal oligodendrocyte progenitors, and myelin basic protein to label differentiated oligodendrocytes, we found an increased number of proliferating QKI- and NG2-..
  21. ncbi Formation of compact myelin is required for maturation of the axonal cytoskeleton
    S T Brady
    University of Texas Southwestern Medical Center, Department of Cell Biology and Neuroscience, Dallas, Texas 75235 9039, USA
    J Neurosci 19:7278-88. 1999
    ..The shiverer mutant mouse has a deletion in the myelin basic protein gene that eliminates compact myelin in the CNS...
  22. ncbi K+ channel distribution and clustering in developing and hypomyelinated axons of the optic nerve
    M N Rasband
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Neurocytol 28:319-31. 1999
    ..Developmental studies in hypomyelinating Shiverer mice revealed dramatically disrupted axoglial junctions, aberrant Na(+) channel clusters, and little or no ..
  23. ncbi Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor
    Y Qi
    Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY 40292, USA
    Development 128:2723-33. 2001
    ..We show that Nkx2.2 is also expressed in mammalian oligodendrocyte progenitors and that the differentiation of MBP-positive and PLP-DM20-positive oligodendrocytes is dramatically retarded in Nkx2...
  24. pmc Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10
    C Claus Stolt
    Institut fur Biochemie, Universitat Erlangen Nurnberg, 91054 Erlangen, Germany
    Genes Dev 16:165-70. 2002
    ..Sox10 directly regulates myelin gene expression in oligodendrocytes, but does not control erbB3 expression as in peripheral glia. Sox10 thus functions in peripheral and central glia at different stages and through different mechanisms...
  25. ncbi Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection
    Q Richard Lu
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Cell 109:75-86. 2002
    ..Neither Olig gene is required for astrocytes. These findings, together with fate mapping analysis of Olig-expressing cells, indicate that oligodendrocytes are derived from Olig-specified progenitors that give rise also to neurons...
  26. pmc The Sox9 transcription factor determines glial fate choice in the developing spinal cord
    C Claus Stolt
    Institut fur Biochemie, Universität Erlangen Nuremberg, 91054 Erlangen, Germany
    Genes Dev 17:1677-89. 2003
    ....
  27. ncbi The transmembrane semaphorin Sema4D/CD100, an inhibitor of axonal growth, is expressed on oligodendrocytes and upregulated after CNS lesion
    Caroline Moreau-Fauvarque
    Institut National de la Santé et de la Recherche Médicale U106, Hopital de la Salpetriere, 75013 Paris, France
    J Neurosci 23:9229-39. 2003
    ..This upregulation was transient because from 1 month after the lesion, Sema4D expression was back to its normal level. These results indicate that Sema4D is a novel inhibitory factor for axonal regeneration expressed in myelin...
  28. ncbi An immunodominant epitope of myelin basic protein is an amphipathic alpha-helix
    Ian R Bates
    Department of Molecular Biology and Genetics, and Biophysics Interdepartmental Group, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Biol Chem 279:5757-64. 2004
    b>Myelin basic protein is a candidate autoantigen in multiple sclerosis. One of its dominant antigenic epitopes is segment Pro85 to Pro96 (human sequence numbering, corresponding to Pro82 to Pro93 in the mouse)...
  29. ncbi Transcription factors Sox8 and Sox10 perform non-equivalent roles during oligodendrocyte development despite functional redundancy
    C Claus Stolt
    Institut fur Biochemie, Universitat Erlangen, Fahrstrasse 17, D 91054 Erlangen, Germany
    Development 131:2349-58. 2004
    ..Resulting differences in protein amounts might be a main reason for the weaker impact of Sox8 on oligodendrocyte development and for unidirectional compensation of the Sox8 loss by Sox10...
  30. ncbi CD8+ T cells maintain tolerance to myelin basic protein by 'epitope theft'
    Antoine Perchellet
    Department of Immunology, University of Washington, Box 357650, Seattle, Washington 98195, USA
    Nat Immunol 5:606-14. 2004
    b>Myelin basic protein-specific CD8(+) T cells can induce central nervous system autoimmunity; however, immune tolerance prevents these autoreactive cells from causing disease...
  31. pmc Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia
    Julia M Edgar
    Applied Neurobiology Group, Institute of Comparative Medicine, University of Glasgow, Scotland, UK
    J Cell Biol 166:121-31. 2004
    ..Our data demonstrate a novel role for oligodendrocytes in the local regulation of axonal function and have implications for the axonal loss associated with secondary progressive multiple sclerosis...
  32. pmc The class III POU domain protein Brn-1 can fully replace the related Oct-6 during schwann cell development and myelination
    Ralf P Friedrich
    Institut fur Biochemie, Universitat Erlangen, Fahrstrasse 17, 91054 Erlangen, Germany
    Mol Cell Biol 25:1821-9. 2005
    ..Similar to Oct-6, Brn-1 down-regulated its own expression at later stages of myelination. Thus, class III POU domain proteins can fully replace each other in Schwann cell development...
  33. ncbi Combinatorial profiles of oligodendrocyte-selective classes of transcriptional regulators differentially modulate myelin basic protein gene expression
    Solen Gokhan
    Institute for Brain Disorders and Neural Regeneration, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 25:8311-21. 2005
    ..Transient transfections of these precise combinatorial codes with a luciferase reporter gene driven by the myelin basic protein promoter define how changes in the molecular composition of these transcriptional complexes modulate myelin ..
  34. pmc Statistical diffusion tensor histology reveals regional dysmyelination effects in the shiverer mouse mutant
    J Michael Tyszka
    Biological Imaging Center, Division of Biology, California Institute of Technology, 2Q Broad 114 96, 1200 E California Blvd, Pasadena, CA 91125, USA
    Neuroimage 29:1058-65. 2006
    ..important model of central nervous system dysmyelination characterized by a deletion in the gene encoding myelin basic protein with relevance to human dysmyelinating and demyelinating diseases...
  35. ncbi Myelin basic protein functions as a microtubule stabilizing protein in differentiated oligodendrocytes
    M R Galiano
    CIQUIBIC Dpto Química Biológica, Facultad Ciencias Quimicas, Haya de la Torre S N, Cordoba, Argentina
    J Neurosci Res 84:534-41. 2006
    b>Myelin basic protein (MBP) is an oligodendrocyte-specific protein essential for oligodendrocyte morphogenesis at late stages of cell differentiation...
  36. ncbi Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence
    Susanne Kellerer
    Institut fur Biochemie, Universitat Erlangen, Fahrstrasse 17, D 91054 Erlangen, Germany
    Development 133:2875-86. 2006
    ..We conclude that the extent of functional equivalence depends on the tissue and that, despite their relatedness, Sox8 and Sox10 have more unique functions than previously appreciated...
  37. ncbi An oligodendrocyte-specific zinc-finger transcription regulator cooperates with Olig2 to promote oligodendrocyte differentiation
    Shu Zong Wang
    Center for Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Development 133:3389-98. 2006
    ..Its expression increases in parallel with that of major myelin genes Mbp and Plp1. Zfp488 is a nuclear protein that possesses transcriptional repression activity...
  38. ncbi SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function
    C Claus Stolt
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, D 91054 Erlangen, Germany
    Dev Cell 11:697-709. 2006
    ..Our studies reveal a complex regulatory network between different groups of Sox proteins that is essential for proper progression of oligodendrocyte development...
  39. ncbi Regulatory T cells maintain long-term tolerance to myelin basic protein by inducing a novel, dynamic state of T cell tolerance
    Sarah E Cabbage
    Molecular and Cellular Biology Program, Department of Immunology, University of Washington, Seattle, WA 98195, USA
    J Immunol 178:887-96. 2007
    The pathogenesis of multiple sclerosis involves a breakdown in T cell tolerance to myelin proteins like myelin basic protein (MBP)...
  40. ncbi Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages
    Silke Schreiner
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, Fahrstrasse 17, D 91054 Erlangen, Germany
    Development 134:3271-81. 2007
    ....
  41. doi Sox9 and Sox10 influence survival and migration of oligodendrocyte precursors in the spinal cord by regulating PDGF receptor alpha expression
    Markus Finzsch
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, Fahrstrasse 17, D 91054 Erlangen, Germany
    Development 135:637-46. 2008
    ..We thus conclude that Sox9 and Sox10 are required in a functionally redundant manner in oligodendrocyte precursors for PDGF-dependent survival and migration...
  42. pmc Opalin, a transmembrane sialylglycoprotein located in the central nervous system myelin paranodal loop membrane
    Fumio Yoshikawa
    Laboratory for Molecular Neurogenesis and Laboratory for Neural Architecture, RIKEN Brain Science Institute, Wako, Japan
    J Biol Chem 283:20830-40. 2008
    ..These results suggest a role for highly sialylglycosylated Opalin in an intermembranous function of the myelin paranodal loops in the central nervous system...
  43. pmc Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse
    Sharon W Way
    Division of Medical Genetics, Department of Pediatrics, University of Texas Health Science Center, Houston, TX 77030, USA
    Hum Mol Genet 18:1252-65. 2009
    ..Given the similarities between the mouse and the human TSC lesions, this model will be useful in further understanding TSC brain pathophysiology, testing potential therapies and identifying other genetic pathways that are altered in TSC...
  44. pmc Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation
    Shih Chu Kao
    Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Science 323:651-4. 2009
    ..Our studies demonstrate that calcineurin and NFAT are essential for neuregulin and ErbB signaling, neural crest diversification, and differentiation of Schwann cells...
  45. pmc HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction
    Feng Ye
    Department of Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, USA
    Nat Neurosci 12:829-38. 2009
    ..Thus, crosstalk between HDAC1/2 and the canonical Wnt signaling pathway mediated by TCF7L2 serves as a regulatory mechanism for oligodendrocyte differentiation...
  46. doi Structural polymorphism and multifunctionality of myelin basic protein
    George Harauz
    Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    Biochemistry 48:8094-104. 2009
    ..of oligodendrocyte lineage (golli) gives rise to a variety of developmentally regulated splice isoforms of myelin basic protein (MBP), denoted golli for early forms and classic for later ones...
  47. doi Structural analysis of the complex between calmodulin and full-length myelin basic protein, an intrinsically disordered molecule
    Viivi Majava
    Department of Biochemistry, University of Oulu, PO Box 3000, 90014, Oulu, Finland
    Amino Acids 39:59-71. 2010
    b>Myelin basic protein (MBP) is present between the cytoplasmic leaflets of the compact myelin membrane in both the peripheral and central nervous systems, and characterized to be intrinsically disordered in solution...
  48. doi Replacement of mouse Sox10 by the Drosophila ortholog Sox100B provides evidence for co-option of SoxE proteins into vertebrate-specific gene-regulatory networks through altered expression
    François Cossais
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, Fahrstrasse 17, D 91054 Erlangen, Germany
    Dev Biol 341:267-81. 2010
    ....
  49. doi The interaction of zinc with membrane-associated 18.5 kDa myelin basic protein: an attenuated total reflectance-Fourier transform infrared spectroscopic study
    Graham S T Smith
    Department of Molecular and Cellular Biology, University of Guelph, 50 Stone Road East, Guelph, ON, N1G 2W1, Canada
    Amino Acids 39:739-50. 2010
    b>Myelin basic protein (MBP) is an essential structural protein required for tight compaction of the myelin sheath of the central nervous system, and belongs to the family of intrinsically disordered proteins...
  50. doi SOX10 structure-function analysis in the chicken neural tube reveals important insights into its role in human neurocristopathies
    François Cossais
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, Erlangen, Germany
    Hum Mol Genet 19:2409-20. 2010
    ..This contributes to the phenotypic variability of human SOX10 mutations...
  51. doi Interaction of myelin basic protein with actin in the presence of dodecylphosphocholine micelles
    Vladimir V Bamm
    Department of Molecular and Cellular Biology, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1, Canada
    Biochemistry 49:6903-15. 2010
    The 18.5 kDa myelin basic protein (MBP), the most abundant splice isoform in human adult myelin, is a multifunctional, intrinsically disordered protein that maintains compact assembly of the myelin sheath in the central nervous system...
  52. doi Secondary structure and solvent accessibility of a calmodulin-binding C-terminal segment of membrane-associated myelin basic protein
    Lopamudra Homchaudhuri
    Department of Molecular Structure and Function, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
    Biochemistry 49:8955-66. 2010
    b>Myelin basic protein (MBP), specifically the 18.5 kDa isoform, is a peripheral membrane protein and a major component of mammalian central nervous system myelin...
  53. pmc Boundary cap cells are peripheral nervous system stem cells that can be redirected into central nervous system lineages
    Violetta Zujovic
    Centre de Recherche de l Institut du Cerveau et de Moelle épinière, Universite Pierre et Marie Curie Paris 6, Unité Mixte de Recherche S975, 75013 Paris, France
    Proc Natl Acad Sci U S A 108:10714-9. 2011
    ....
  54. pmc Proline substitutions and threonine pseudophosphorylation of the SH3 ligand of 18.5-kDa myelin basic protein decrease its affinity for the Fyn-SH3 domain and alter process development and protein localization in oligodendrocytes
    Graham S T Smith
    Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada
    J Neurosci Res 90:28-47. 2012
    ..The classic 18.5-kDa MBP isoform has a proline-rich region comprising amino acids 92-99 (murine sequence -T(92)PRTPPPS(99)-) that contains a ..
  55. pmc Structured functional domains of myelin basic protein: cross talk between actin polymerization and Ca(2+)-dependent calmodulin interaction
    Vladimir V Bamm
    Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada
    Biophys J 101:1248-56. 2011
    The 18.5-kDa myelin basic protein (MBP), the most abundant isoform in human adult myelin, is a multifunctional, intrinsically disordered protein that maintains compact assembly of the sheath...
  56. pmc Time-lapse imaging of the dynamics of CNS glial-axonal interactions in vitro and ex vivo
    Kalliopi Ioannidou
    Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom
    PLoS ONE 7:e30775. 2012
    ..The main aim of this study was to follow glial-axonal interactions over time both in vitro and ex vivo to visualize the various stages of myelination...
  57. pmc The 21.5-kDa isoform of myelin basic protein has a non-traditional PY-nuclear-localization signal
    Graham S T Smith
    Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada
    Biochem Biophys Res Commun 422:670-5. 2012
    The predominant 18.5-kDa classic myelin basic protein (MBP) is mainly responsible for compaction of the myelin sheath in the central nervous system, but is multifunctional, having numerous interactions with Ca(2+)-calmodulin, actin, ..
  58. pmc Nucleus-localized 21.5-kDa myelin basic protein promotes oligodendrocyte proliferation and enhances neurite outgrowth in coculture, unlike the plasma membrane-associated 18.5-kDa isoform
    Graham S T Smith
    Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada
    J Neurosci Res 91:349-62. 2013
    The classic myelin basic protein (MBP) family of central nervous system (CNS) myelin arises from transcription start site 3 of the Golli (gene of oligodendrocyte lineage) complex and comprises splice isoforms ranging in nominal molecular ..
  59. doi Sox10 cooperates with the mediator subunit 12 during terminal differentiation of myelinating glia
    Michael R Vogl
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen Nurnberg, D 91054 Erlangen, Germany
    J Neurosci 33:6679-90. 2013
    ..We conclude that Sox10 functions during terminal differentiation of myelinating glia, at least in part by Med12-dependent recruitment of the Mediator complex...
  60. pmc Myelin membrane assembly is driven by a phase transition of myelin basic proteins into a cohesive protein meshwork
    Shweta Aggarwal
    Max Planck Institute of Experimental Medicine, Gottingen, Germany
    PLoS Biol 11:e1001577. 2013
    ..Here, we show that myelin basic protein drives myelin biogenesis using weak forces arising from its inherent capacity to phase separate...
  61. pmc Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes
    Stephanie A Hoffmann
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen Nurnberg, D 91054 Erlangen, Germany
    Development 141:39-50. 2014
    ..This study presents one of the few cases in which SoxB1 proteins, including the stem cell factor Sox2, are associated with differentiation rather than precursor functions. ..
  62. pmc Interaction of myelin basic protein with cytoskeletal and signaling proteins in cultured primary oligodendrocytes and N19 oligodendroglial cells
    Joan M Boggs
    Molecular Structure and Function Program, Research Institute, Hospital for Sick Children, 686 Bay St, Toronto, ON M5G 0A4, Canada
    BMC Res Notes 7:387. 2014
    The classic myelin basic protein (MBP) isoforms are intrinsically-disordered proteins of 14-21...
  63. ncbi Dual origin of spinal oligodendrocyte progenitors and evidence for the cooperative role of Olig2 and Nkx2.2 in the control of oligodendrocyte differentiation
    Hui Fu
    Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY 40292, USA
    Development 129:681-93. 2002
    ..In support of this suggestion, inhibition of expression of these two transcription factors in culture by antisense oligonucleotides has an additive inhibitory effect on OLP differentiation and proteolipid protein (PLP) gene expression...
  64. ncbi Electron paramagnetic resonance spectroscopy and molecular modelling of the interaction of myelin basic protein (MBP) with calmodulin (CaM)-diversity and conformational adaptability of MBP CaM-targets
    Eugenia Polverini
    Istituto Nazionale per la Fisica della Materia, Dipartimento di Fisica, Universita di Parma, Parco Area delle Scienze 7 A, 43100 Parma, Italy
    J Struct Biol 148:353-69. 2004
    The classic 18.5 kDa isoform of murine myelin basic protein (mMBP) has been shown to bind calmodulin (CaM) strongly and specifically in vitro...
  65. pmc Heterogeneous nuclear ribonucleoprotein (hnRNP) F is a novel component of oligodendroglial RNA transport granules contributing to regulation of myelin basic protein (MBP) synthesis
    Robin White
    Department of Biology, Molecular Cell Biology, Johannes Gutenberg University of Mainz, Bentzelweg 3, 55128 Mainz, Germany
    J Biol Chem 287:1742-54. 2012
    b>Myelin basic protein (MBP) is a major component of central nervous system (CNS) myelin. The absence of MBP results in the loss of almost all compact myelin in the CNS...
  66. pmc Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants
    Xianting Li
    Departments of Neurology and Neuroscience, Mount Sinai School of Medicine, New York, USA
    J Neurochem 103:238-47. 2007
    ..The distinctive levels of kinase/GTPase activity in brain LRRK2 may help explain LRRK2-associated neuronal functions or dysfunctions in the pathogenesis of PD...
  67. ncbi A novel transcript overlapping the myelin basic protein gene
    B Grima
    Centre de Biologie Cellulaire du CNRS, ERS 28, Ivry Seine, France
    J Neurochem 59:2318-23. 1992
    b>Myelin basic protein (MBP) is a major constituent of myelin synthesized by oligodendrocytes and Schwann cells. We have investigated the expression of mouse MBP RNAs outside the nervous system...
  68. ncbi Chromosomal localization of the murine genes for the alpha- and beta-subunits of calcium/calmodulin-dependent protein kinase II
    M Danciger
    Jules Stein Eye Institute, UCLA School of Medicine 90024
    Mamm Genome 3:122-5. 1992
  69. ncbi A multipoint genetic linkage map of mouse chromosome 18
    K R Johnson
    Jackson Laboratory, Bar Harbor, Maine 04609
    Genomics 13:1143-9. 1992
    ..3-Tpi-10-11.8-(Egr-1, Hmg17-rs9)-2.1-Fgfa-2.2-Grl-1-10.1-(Cdx-1, Csfmr, Pdgfrb, Pdea, Rps14)-2.1-Adrb-2-22.9-Mbp. Pgk-1rs5, Tpi-10, Hmg17-rs9, and Rps14 had not been previously mapped in the mouse; Egr-1 had only been ..
  70. ncbi Expression of a novel transcript of the myelin basic protein gene
    K Kitamura
    Mental Retardation Research Center, UCLA Medical School 90024
    J Neurochem 54:2032-41. 1990
    A cDNA (M41) corresponding to a mouse myelin basic protein (MBP) mRNA with a longer 5'-untranslated region than predicted from earlier studies of MBP gene structure has been isolated and characterized...
  71. ncbi Shiverer jimpy double mutant mice. V. Correlation of genotype and myelin proteins
    A Sinclair
    Department of Neurology, Childrens Hospital, Boston, Mass
    Dev Neurosci 13:138-42. 1991
    We have reexamined the levels of myelin basic protein (MBP) and proteolipid protein (PLP) in the brains of mice bred to carry both the shi/shi and jp/Y hypomyelination defects...
  72. ncbi Regulation of myelin basic protein gene transcription in normal and shiverer mutant mice
    M Wiktorowicz
    Division of Molecular Immunology and Neurobiology, Samuel Lunenfeld Research Institute of Mount Sinai Hospital, Toronto, Canada
    Dev Neurosci 13:143-50. 1991
    We describe the measurement of myelin basic protein gene transcription rate, and of the accumulation of both mature mRNA and total transcripts from the myelin basic protein gene in brains from mice of wild-type and homozygous shiverer ..
  73. ncbi Molecular characterization of the murine mutation myelin deficient
    B Popko
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill 27599
    Epilepsy Res Suppl 4:275-82. 1991
  74. ncbi Oligodendrocytes of the jimpy phenotype can be partially restored by environmental factors in vivo
    F Lachapelle
    U134 INSERM, Hopital de la Salpetriere, Paris, France
    J Neurosci Res 29:235-43. 1991
    Cross-transplantations of neural tissue between jimpy (jp) shiverer (shi) and normal mice have been performed under heterochronic conditions...
  75. ncbi Novel myosin heavy chain encoded by murine dilute coat colour locus
    J A Mercer
    Mammalian Genetics Laboratory, NCI Frederick Cancer Research and Development Center, Maryland 21702
    Nature 349:709-13. 1991
    ..These results suggest an important role for the dilute gene product in the elaboration, maintenance, or function of cellular processes of melanocytes and neurons...
  76. ncbi Alternative splicing accounts for the four forms of myelin basic protein
    F de Ferra
    Cell 43:721-7. 1985
    We have isolated cDNA clones encoding the four different forms of mouse myelin basic protein (MBP) and have analyzed the structure of the MBP gene...
  77. ncbi Myelin deficient mice: expression of myelin basic protein and generation of mice with varying levels of myelin
    B Popko
    Cell 48:713-21. 1987
    ..In this report we demonstrate in mld mice that the gene encoding myelin basic protein (MBP) is expressed at decreased levels and on an abnormal temporal schedule relative to the wild-type gene...
  78. ncbi Comparison of the distribution of Na+,K+-ATPase and myelin-associated glycoprotein (MAG) in the optic nerve, spinal cord and trigeminal ganglion of shiverer (shi/shi) and control (+/+) mice
    H J Sheedlo
    Brain Res 415:105-14. 1987
    ..sections of the spinal cord, optic nerve and trigeminal ganglion of adult control (+/+) and CNS myelin-deficient shiverer (shi/shi) mice...
  79. ncbi (Na+ + K+)-adenosinetriphosphatase in the brain of Shiverer (Shi/Shi) mice
    H J Sheedlo
    Department of Neurology, University of Michigan, Ann Arbor 48109
    Neurochem Res 12:1081-6. 1987
    The myelin-deficient Shiverer (Shi/Shi) mutant mouse may be a useful model in assessing the dependence of brain (Na+ + K+)-ATPase concentration and composition on myelin membrane formation...
  80. ncbi A survey of neurological mutant mice. II. Lipid composition of myelinated tissue in possible myelin mutants
    A L Ganser
    Department of Neuroscience, Children s Hospital, Boston, Mass
    Dev Neurosci 10:123-40. 1988
    ..abstract truncated at 400 words)..
  81. ncbi Compact myelin exists in the absence of basic protein in the shiverer mutant mouse
    D A Kirschner
    Nature 283:207-10. 1980
  82. ncbi Peripheral nervous system of shiverer mutant mice: developmental change of myelin components and immunohistochemical demonstration of the absence of MBP and presence of P2 protein
    K Mikoshiba
    Brain Res 283:71-9. 1983
    ..it was found from the SDS-polyacrylamide gel electrophoresis that the Pl and Pr proteins equivalent to myelin basic protein of CNS and PM protein were missing in the shiverer in both P2A and P3A fractions in which PNS myelin is ..
  83. ncbi Effects of carbonic anhydrase II (CAII) deficiency on CNS structure and function in the myelin-deficient CAII-deficient double mutant mouse
    W Cammer
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci Res 40:451-7. 1995
    ..Since myelin basic protein also takes part in myelin compaction, we bred double CAII-deficient, myelin-deficient (Mld) mutant mice, in ..
  84. ncbi Cerebellar soluble lectin and its glycoprotein ligands in the developing brain of control and dysmyelinating mutant mice
    W X Li
    Unite de Neurobiologie Cellulaire, Moleculaire et Clinique, INSERM U, 134, Hopital de la Salpetriere, Paris, France
    Neurochem Int 22:125-33. 1993
    ..glycoprotein ligands were studied using immunoblotting and affinoblotting techniques in the forebrain of quaking, shiverer and jimpy dysmyelinating mutant mice and their respective control littermates during the postnatal development...
  85. ncbi Myelin mutants: new models and new observations
    K F Lunn
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin Madison 53706, USA
    Microsc Res Tech 32:183-203. 1995
    ..These findings underscore the complexity of the myelination process and highlight the numerous ways in which it can be disrupted...
  86. ncbi Membrane adhesion and other functions for the myelin basic proteins
    S M Staugaitis
    Department of Pathology, Columbia Presbyterian Medical Center, New York, USA
    Bioessays 18:13-8. 1996
    ..We now think that while the major MBPs are intracellular adhesion molecules, some of the quantitatively less abundant isoforms that are expressed very early in development may have regulatory effects on the myelination program...
  87. ncbi Vacuolar myelopathy in transgenic mice expressing human immunodeficiency virus type 1 proteins under the regulation of the myelin basic protein gene promoter
    G Goudreau
    Laboratory of Molecular Biology, Clinical Research Institute of Montreal, Quebec, Canada
    Nat Med 2:655-61. 1996
    ..This animal model provides in vivo evidence linking the expression of HIV-1 proteins in oligodendrocytes to the spinal cord damage found in vacuolar myelopathy...
  88. ncbi Myelin basic protein gene expression in neurons: developmental and regional changes in protein targeting within neuronal nuclei, cell bodies, and processes
    C F Landry
    Mental Retardation Research Center, Neuropsychiatric Institute, University of California at Los Angeles School of Medicine, California 90024, USA
    J Neurosci 16:2452-62. 1996
    The myelin basic protein (MBP) gene is part of the golli-mbp gene complex...
  89. ncbi Evidence that some oligodendrocyte progenitors in the developing optic pathway express the plp gene
    M L Fanarraga
    Department of Anatomy and Cell Biology, University of Cantabria, Santander, Spain
    Glia 18:282-92. 1996
    ..Small unbranched cells expressing DM-20 but not myelin basic protein (MBP) and probably representing progenitors were detectable by immunostaining in similar locations...
  90. ncbi Functional analysis in vivo of the double mutant mouse deficient in both proteolipid protein (PLP) and myelin basic protein (MBP) in the central nervous system
    W Stoffel
    Institute of Biochemistry, D 50931 Köln, Germany
    Cell Tissue Res 289:195-206. 1997
    ..To unravel the functions of the two dominant myelin proteins in the CNS, proteolipid protein (PLP) and myelin basic protein (MBP), we generated and characterized the homozygous double mutant mouse line (plp-/-, mbp-/-), which is ..
  91. ncbi Regulation of cytoskeleton by myelin components: studies on shiverer oligodendrocytes carrying an Mbp transgene
    C A Dyer
    Department of Biomedical Sciences, E K Shriver Center, Waltham, Mass, USA
    Dev Neurosci 19:395-409. 1997
    Oligodendrocytes from the shiverer mutant mouse are missing most of the myelin basic protein (Mbp) gene. In axon-free cultures, they produce membrane sheets with abnormally assembled microtubule and actin-based structures...
  92. ncbi Neurosteroid progesterone is up-regulated in the brain of jimpy and shiverer mice
    C Le Goascogne
    INSERM U 488, Bicetre, France
    Glia 29:14-24. 2000
    Concentrations of neurosteroids have been measured in the brains of postnatal myelin mutants jimpy (jp) and shiverer (shi) mice and of their normal controls...
  93. ncbi Quaking*shiverer double-mutant mice survive for at least 100 days with no CNS myelin
    M K Wolf
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Dev Neurosci 21:483-90. 1999
    ..We demonstrate that quaking*shiverer double-mutant mice can survive for at least 100 days without any CNS myelin whatsoever...
  94. ncbi Myelin basic protein is necessary for the regulation of myelin-associated glycoprotein expression in mouse oligodendroglia
    J Nakahara
    Department of Neurobiology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashi ku, 173 0015, Tokyo, Japan
    Neurosci Lett 298:163-6. 2001
    ..We propose here that myelin basic protein (MBP) is prerequisite, which is more diffusely expressed than MAG in early stages of myelination...
  95. ncbi Activation of myelin genes during transdifferentiation from melanoma to glial cell phenotype
    Shalom G Slutsky
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 278:8960-8. 2003
    ..as ligand interleukin-6 fused to its soluble receptor (IL6RIL6), causes induction of myelin genes such as myelin basic protein (MBP) and myelin protein zero (Po) in embryonic dorsal root ganglia Schwann cells...
  96. ncbi The protooncogene Ski controls Schwann cell proliferation and myelination
    Suzana Atanasoski
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich, Switzerland
    Neuron 43:499-511. 2004
    ..The myelination-regulating transcription factor Oct6 is involved in a complex modulatory relationship with Ski. We conclude that Ski is a crucial signal in Schwann cell development and myelination...
  97. ncbi Developmental abnormalities of myelin basic protein expression in fyn knock-out brain reveal a role of Fyn in posttranscriptional regulation
    Zifan Lu
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 280:389-95. 2005
    ..does not affect the expression of mRNAs that encode myelin structural proteins, including that for the myelin basic protein (MBP), until postnatal day 13 (P13)...
  98. ncbi Gli3 mutation rescues the generation, but not the differentiation, of oligodendrocytes in Shh mutants
    Min Tan
    Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY 40292, USA
    Brain Res 1067:158-63. 2006
    ....
  99. ncbi Evidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tube
    Tao Sun
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Dev Biol 292:152-64. 2006
    ..Our findings indicate complex regulation of Olig2 by stage- and lineage-specific regulatory elements. They further suggest that transcriptional regulation of Olig2 is involved in segregation of pMN neuroblasts...
  100. doi Control of glial precursor cell development in the mouse optic nerve by sonic hedgehog from retinal ganglion cells
    Gabriel D Dakubo
    Ottawa Health Research Institute, Ottawa, ON, Canada K1H 8L6
    Brain Res 1228:27-42. 2008
    ..RGC-derived Shh signalling isthus necessary in vivo for maintenance of astrocyte proliferation, affecting both axo-glial and normal glial cell development in the optic nerve...
  101. pmc Swift entry of myelin-specific T lymphocytes into the central nervous system in spontaneous autoimmune encephalomyelitis
    Glaucia C Furtado
    Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 181:4648-55. 2008
    ..Using a model of spontaneous EAE, we demonstrated that myelin basic protein (MBP)-specific CD4(+) T cells up-regulate activation markers in the CNS-draining cervical lymph nodes at a ..

Research Grants8

  1. PROTEIN SYNTHESIS INITIATION IN ANIMAL CELLS
    Bansidhar Datta; Fiscal Year: 2002
    ..This research is expected to provide valuable information regarding the mechanism of protein synthesis initiation in normal, cancerous, and virus- infected animal cells. ..
  2. GENETIC ELEMENTS REGULATING MYELIN GENE EXPRESSION
    Anthony Campagnoni; Fiscal Year: 2001
    DESCRIPTION: The Golli-mbp gene encodes two families of proteins, the Golli proteins and the myelin basic proteins...
  3. Protective Effect of Pregnancy Doses of Estrogens in EAE
    Rhonda Voskuhl; Fiscal Year: 2005
    ..abstract_text> ..
  4. NO DAMAGE TO FOLATE CYCLE IN THE CENTRAL NERVOUS SYSTEM
    Kenneth Hensley; Fiscal Year: 2005
    ..abstract_text> ..
  5. Golli-MBP Gene Expression in the Nervous System
    Anthony Campagnoni; Fiscal Year: 2007
    ..Successful completion of these aims will, we believe, establish that another function of the myelin basic protein gene, through its golli products, is to modulate signaling events important for process and neurite ..
  6. Sex Chromosome Effects in Lupus
    Rhonda Voskuhl; Fiscal Year: 2008
    ..This disease was chosen in light of the 9:1 female preponderance of the human disease system lupus erythematosus. [unreadable] [unreadable] [unreadable]..
  7. The Effect of Sex Chromosomes on Immune Responses
    Rhonda Voskuhl; Fiscal Year: 2009
    ..inhibitory, for cytokine production of lymph node cells (LNCs) from SJL mice immunized with the autoantigen myelin basic protein (MBP)...
  8. Synthesis and Assembly of Basic Proteins into Myelin.
    Anthony Campagnoni; Fiscal Year: 2009
    ..These studies are relevant to demyelinating diseases, like MS and leukodystrophies, and will enhance our understanding of myelination, remyelination and the effects of hypomyelination on neural function. ..