Genomes and Genes
Gene Symbol: Matn1
Description: matrilin 1, cartilage matrix protein
Alias: CMP, Crtm, Mat1, matrilin-1, cartilage matrix protein, matrilin 1, cartilage matrix protein 1
- The transcription factors L-Sox5 and Sox6 are essential for cartilage formationP Smits
Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
Dev Cell 1:277-90. 2001..L-Sox5 and Sox6 are thus redundant, potent enhancers of chondroblast functions, thereby essential for endochondral skeleton formation...
- Normal skeletal development of mice lacking matrilin 1: redundant function of matrilins in cartilage?A Aszodi
Department of Experimental Pathology, Lund University, 221 85 Lund, Sweden
Mol Cell Biol 19:7841-5. 1999Matrilin 1, or cartilage matrix protein, is a member of a novel family of extracellular matrix proteins. To date, four members of the family have been identified, but their biological role is unknown...
- Lineage tracing using matrilin-1 gene expression reveals that articular chondrocytes exist as the joint interzone formsGareth Hyde
Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, The University of Manchester, Manchester M13 9PT, UK
Dev Biol 304:825-33. 2007We have developed a mouse in which the Cre recombinase gene has been targeted to exon 1 of the matrilin-1 gene (Matn1) to investigate the origins of articular chondrocytes and the development of the knee joint...
- Abnormal collagen fibrils in cartilage of matrilin-1/matrilin-3-deficient miceClaudia Nicolae
Department of Molecular Medicine, Max Planck Institute for Biochemistry, Martinsried, Germany
J Biol Chem 282:22163-75. 2007..Surprisingly, however, Matn3-null as well as Matn1- and Matn2-null mice do not show an overt skeletal phenotype, suggesting a dominant negative pathomechanism for ..
- Differential gene expression of the intermediate and outer interzone layers of developing articular cartilage in murine embryosFlorien Jenner
1 Equine University Hospital, Department of Companion Animals and Horses, University of Veterinary Medicine Vienna, Vienna, Austria
Stem Cells Dev 23:1883-98. 2014..The high representation of genes relevant to chondrocyte hypertrophy and endochondral ossification in the outer interzone suggests that it undergoes endochondral ossification...
- Functional knockout of the matrilin-3 gene causes premature chondrocyte maturation to hypertrophy and increases bone mineral density and osteoarthritisLouise van der Weyden
Mouse Genomics Lab, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom
Am J Pathol 169:515-27. 2006..However, by 18 weeks of age, Matn3 null mice had a significantly higher total body bone mineral density than Matn1 null mice or wild-type littermates...
- Detection of genes regulated by Lmx1b during limb dorsalizationJennifer M Feenstra
Division of Human Anatomy, Department of Pathology and Human Anatomy, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
Dev Growth Differ 54:451-62. 2012..Our study provides the most comprehensive characterization of genes regulated by Lmx1b during limb development to-date and provides targets for further investigation...
- Hmgb1 can facilitate activation of the matrilin-1 gene promoter by Sox9 and L-Sox5/Sox6 in early steps of chondrogenesisTibor Szénási
Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, H 6701 Szeged, Hungary Electronic address
Biochim Biophys Acta 1829:1075-91. 2013..Here we report its contribution to the evolutionarily conserved, distinctive regulation of the matrilin-1 gene (Matn1) expression in amniotes...
- Mesenchyme-specific knockout of ESET histone methyltransferase causes ectopic hypertrophy and terminal differentiation of articular chondrocytesKevin A Lawson
From the Department of Orthopedics and Sports Medicine, University of Washington, Seattle, Washington 98108 and
J Biol Chem 288:32119-25. 2013....
- Matrilin-1 is an inhibitor of neovascularizationMatthew J Foradori
From the Program in Vascular Biology and Department of Surgery, Boston Children s Hospital, Boston, Massachusetts 02115 and Harvard Medical School, Boston, Massachusetts 02115
J Biol Chem 289:14301-9. 2014....
- Loss of matrilin 1 does not exacerbate the skeletal phenotype in a mouse model of multiple epiphyseal dysplasia caused by a Matn3 V194D mutationPeter A Bell
University of Manchester, Manchester, UK
Arthritis Rheum 64:1529-39. 2012..it was proposed that secretion of mutant matrilin 3 may be dependent on the formation of hetero-oligomers with matrilin 1. The aim of this study was to investigate the hypothesis that deletion of matrilin 1 would abolish the formation ..
- Mice lacking matrilin-1 (cartilage matrix protein) have alterations in type II collagen fibrillogenesis and fibril organizationX Huang
Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
Dev Dyn 216:434-41. 1999Matrilin-1 (cartilage matrix protein) is a homotrimeric protein that forms collagen-dependent and collagen-independent fibrils in the extracellular matrix of cartilage...
- Synovial joint formation requires local Ext1 expression and heparan sulfate production in developing mouse embryo limbs and spineChristina Mundy
Department of Orthopaedic Surgery, College of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
Dev Biol 351:70-81. 2011..The data indicate also that defects in joint formation reverberate on, and delay, overall long bone growth...
- Muscle contraction is necessary to maintain joint progenitor cell fateJoy Kahn
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
Dev Cell 16:734-43. 2009..In conclusion, our findings provide the missing link between progenitor cell fate determination and embryonic movement, two processes shown to be essential for correct organogenesis...
- The extracellular-matrix protein matrilin 2 participates in peripheral nerve regenerationDmitry Malin
Centre for Molecular Neurobiology, University of Hamburg, D 20251 Hamburg, Germany
J Cell Sci 122:995-1004. 2009..These results show that matrilin 2 is a permissive substrate for axonal growth and cell migration, and that it is required for successful nerve regeneration...
- Impaired neurogenesis in embryonic spinal cord of Phgdh knockout mice, a serine deficiency disorder modelYuriko Kawakami
Laboratory of Metabolic Regulation Research, Kyushu University Bio Architecture Center, Fukuoka 812 8581, Japan Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812 8581, Japan
Neurosci Res 63:184-93. 2009..The present integrative study provides in vivo evidence that normal cell cycle progression and subsequent neurogenesis of radial glia cells are severely impaired by serine deficiency...
- Transgenic mice expressing D469Delta mutated cartilage oligomeric matrix protein (COMP) show growth plate abnormalities and sternal malformationsMarkus Schmitz
Center for Biochemistry, Medical Faculty, University of Cologne, Joseph Stelzmann Str 52, D 50931 Cologne, Germany
Matrix Biol 27:67-85. 2008..Later in development, the growth plate was irregularly shaped and prematurely invaded by bony tissue. In addition, a fusion of the third and fourth sternebrae was frequently observed...
- The cartilage matrix protein subdomain of type VII collagen is pathogenic for epidermolysis bullosa acquisitaMei Chen
Department of Dermatology, The Keck School of Medicine, University of Southern California, 1303 Mission Road, Los Angeles, CA 90033, USA
Am J Pathol 170:2009-18. 2007..domain corresponding to the N-terminal 227 amino acids (residues 1 to 227), which contains homology with cartilage matrix protein (CMP)...
- Pericellular matrilins regulate activation of chondrocytes by cyclic load-induced matrix deformationKatsuaki Kanbe
Department of Orthopaedic Surgery, Tokyo Women s Medical University Medical Center East, Japan
J Bone Miner Res 22:318-28. 2007..Thus, pericellular matrilins may play a role in chondrocyte mechanotransduction...
- Ablation of calcitonin/calcitonin gene-related peptide-alpha impairs fetal magnesium but not calcium homeostasisKirsten R McDonald
Faculty of Medicine Endocrinology, Memorial University of Newfoundland, St John s, Canada
Am J Physiol Endocrinol Metab 287:E218-26. 2004..These findings indicate that calcitonin and CGRPalpha are not needed for normal fetal calcium metabolism but may regulate aspects of fetal Mg metabolism...
- Expression of matrilin-1, -2 and -3 in developing mouse limbs and heartD Segat
Institute for Biochemistry, Medical Faculty, University of Cologne, D 50931, Cologne, Germany
Matrix Biol 19:649-55. 2000..The complementary, but in part overlapping, expression of matrilins indicates the possibility for both redundant and unique functions among the members of this novel family of extracellular matrix proteins...
- Primary structure and expression of matrilin-2, the closest relative of cartilage matrix protein within the von Willebrand factor type A-like module superfamilyF Deak
Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, P O Box 521, Szeged H 6701, Hungary
J Biol Chem 272:9268-74. 1997..A sequence similarity search indicated the closest relation to the trimeric cartilage matrix protein (CMP)...
- Sequence, structure and chromosomal localization of Crtm gene encoding mouse cartilage matrix protein and its exclusion as a candidate for murine achondroplasiaA Aszodi
Department of Experimental Pathology, University Hospital, Lund, Sweden
Matrix Biol 16:563-73. 1998The mouse cartilage matrix protein gene (Crtm) was isolated from a cosmid library using a mouse Crtm cDNA fragment as probe. Crtm spans 12.2 kb from the start of translation to the polyadenylation signal sequence and comprises eight exons...
- Disrupted expression of matrix genes in the growth plate of the mouse cartilage matrix deficiency (cmd) mutantA W Wai
Department of Biochemistry, University of Hong Kong, China
Dev Genet 22:349-58. 1998..The discordance of gene expression in cmd chondrocytes may be additional factors contributing to the disrupted cellular architecture of the growth plate resulting from the primary absence of aggrecan...
- Collagen II is essential for the removal of the notochord and the formation of intervertebral discsA Aszodi
Department of Experimental Pathology, Lund University, 22185 Lund, Sweden
J Cell Biol 143:1399-412. 1998....
- Perlecan maintains the integrity of cartilage and some basement membranesM Costell
Department of Experimental Pathology, Lund University, S 221 85 Lund, Sweden
J Cell Biol 147:1109-22. 1999....
- Distribution of cartilage molecules in the developing mouse jointJ M Murphy
Osiris Therapeutics Inc, Baltimore, MD 21231, USA
Matrix Biol 18:487-97. 1999..of protein distribution for aggrecan, fibromodulin, cartilage oligomeric matrix protein (COMP) and cartilage matrix protein (CMP) in the developing mouse limb with particular attention to those cells destined to form articular ..
- Ermap, a gene coding for a novel erythroid specific adhesion/receptor membrane proteinT Z Ye
Department of Pathology and Molecular Medicine, McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada
Gene 242:337-45. 2000..Northern blot analysis and in-situ hybridization demonstrated that Ermap expression was restricted to fetal and adult erythroid tissues. ERMAP is likely a novel adhesion/receptor molecule specific for erythroid cells...
- The matrilins: a growing family of A-domain-containing proteinsM Paulsson
Institute for Biochemistry, Medical Faculty, University of Cologne, Germany
Biochem Soc Trans 27:824-6. 1999
- WARP is a novel multimeric component of the chondrocyte pericellular matrix that interacts with perlecanJustin M Allen
Cell and Matrix Biology Research Unit, Murdoch Childrens Research Institute and Department of Paediatrics, University of Melbourne, Royal Children s Hospital, Flemington Road, Parkville, Victoria 3052, Australia
J Biol Chem 281:7341-9. 2006..We conclude that WARP forms macromolecular structures that interact with perlecan to contribute to the assembly and/or maintenance of "permanent" cartilage structures during development and in mature cartilages...
- Molecular structure, processing, and tissue distribution of matrilin-4A R Klatt
Institute for Biochemistry and the Center for Molecular Medicine Cologne Service Laboratory, Medical Faculty, University of Cologne, Joseph Stelzmann Strasse 52, D 50931 Cologne, Germany
J Biol Chem 276:17267-75. 2001..In the matrix formed by cultured primary embryonic fibroblasts, matrilin-4 is found in a filamentous network connecting individual cells...
- The role of collagen II and cartilage fibril-associated molecules in skeletal developmentA Aszodi
Department of Experimental Pathology, Lund University, Sweden
Osteoarthritis Cartilage 9:S150-9. 2001..To understand the role some of these molecules in skeletal development, we have generated transgenic mouse strains harboring ablated genes for collagens II and IX, and matrilin-1...
- Expression of matrilins during maturation of mouse skeletal tissuesAndreas R Klatt
Institute for Biochemistry II, Medical Faculty, University of Cologne, Joseph Stelzmann Str 52, D 50931 Cologne, Germany
Matrix Biol 21:289-96. 2002..During joint development matrilin-2 and matrilin-4 are present at the developing joint surface, while in articular cartilage of 6-week-old mice all matrilins are only weakly expressed...
- Matrilin-3 is dispensable for mouse skeletal growth and developmentYaping Ko
Center for Biochemistry, Medical Faculty, University of Cologne, D 50931 Cologne, Germany
Mol Cell Biol 24:1691-9. 2004..Altogether, our findings suggest functional redundancy among matrilins and demonstrate that the phenotypes of MED disorders are not caused by the absence of matrilin-3 in cartilage ECM...
- Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth platePatrick Smits
Dept of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, ND 20, Cleveland, OH 44195, USA
J Cell Biol 164:747-58. 2004..In conclusion, Sox5 and Sox6 are needed for the establishment of multilayered growth plates, and thereby for proper and timely development of endochondral bones...
- Cloning, sequencing and expression analysis of mouse cartilage matrix protein cDNAA Aszodi
Institute for Animal Sciences, Agricultural Biotechnology Center, Godollo, Hungary
Eur J Biochem 236:970-7. 1996A cDNA encoding the mouse cartilage matrix protein (CMP) was cloned following the reverse-transcription polymerase chain reaction and rapid amplification of cDNA ends procedures using mRNA isolated from trachea...
- Mice lacking the extracellular matrix adaptor protein matrilin-2 develop without obvious abnormalitiesLajos Mátés
Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, H 6701 Szeged, Hungary
Matrix Biol 23:195-204. 2004....
- Strategies Towards Gene Therapy for Dystrophic Epidermolysis BullosaMei Chen; Fiscal Year: 2009..We believe the proposed experiments will give us sufficient information to consider clinical protocols for humans, the long-term goal of this work. ..