Matn1

Summary

Gene Symbol: Matn1
Description: matrilin 1, cartilage matrix protein
Alias: CMP, Crtm, Mat1, matrilin-1, cartilage matrix protein, matrilin 1, cartilage matrix protein 1
Species: mouse

Top Publications

  1. ncbi The transcription factors L-Sox5 and Sox6 are essential for cartilage formation
    P Smits
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Dev Cell 1:277-90. 2001
  2. pmc Normal skeletal development of mice lacking matrilin 1: redundant function of matrilins in cartilage?
    A Aszodi
    Department of Experimental Pathology, Lund University, 221 85 Lund, Sweden
    Mol Cell Biol 19:7841-5. 1999
  3. pmc Lineage tracing using matrilin-1 gene expression reveals that articular chondrocytes exist as the joint interzone forms
    Gareth Hyde
    Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, The University of Manchester, Manchester M13 9PT, UK
    Dev Biol 304:825-33. 2007
  4. ncbi Abnormal collagen fibrils in cartilage of matrilin-1/matrilin-3-deficient mice
    Claudia Nicolae
    Department of Molecular Medicine, Max Planck Institute for Biochemistry, Martinsried, Germany
    J Biol Chem 282:22163-75. 2007
  5. pmc Differential gene expression of the intermediate and outer interzone layers of developing articular cartilage in murine embryos
    Florien Jenner
    1 Equine University Hospital, Department of Companion Animals and Horses, University of Veterinary Medicine Vienna, Vienna, Austria
    Stem Cells Dev 23:1883-98. 2014
  6. pmc Functional knockout of the matrilin-3 gene causes premature chondrocyte maturation to hypertrophy and increases bone mineral density and osteoarthritis
    Louise van der Weyden
    Mouse Genomics Lab, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom
    Am J Pathol 169:515-27. 2006
  7. pmc Detection of genes regulated by Lmx1b during limb dorsalization
    Jennifer M Feenstra
    Division of Human Anatomy, Department of Pathology and Human Anatomy, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    Dev Growth Differ 54:451-62. 2012
  8. doi Hmgb1 can facilitate activation of the matrilin-1 gene promoter by Sox9 and L-Sox5/Sox6 in early steps of chondrogenesis
    Tibor Szénási
    Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, H 6701 Szeged, Hungary Electronic address
    Biochim Biophys Acta 1829:1075-91. 2013
  9. pmc Mesenchyme-specific knockout of ESET histone methyltransferase causes ectopic hypertrophy and terminal differentiation of articular chondrocytes
    Kevin A Lawson
    From the Department of Orthopedics and Sports Medicine, University of Washington, Seattle, Washington 98108 and
    J Biol Chem 288:32119-25. 2013
  10. pmc Matrilin-1 is an inhibitor of neovascularization
    Matthew J Foradori
    From the Program in Vascular Biology and Department of Surgery, Boston Children s Hospital, Boston, Massachusetts 02115 and Harvard Medical School, Boston, Massachusetts 02115
    J Biol Chem 289:14301-9. 2014

Scientific Experts

  • Mei Chen
  • A Aszodi
  • Claudia Nicolae
  • Raimund Wagener
  • Mats Paulsson
  • Qian Chen
  • Lajos Mátés
  • Nicolai Miosge
  • Matthew J Foradori
  • Florien Jenner
  • Kevin A Lawson
  • M Paulsson
  • Tibor Szénási
  • Peter A Bell
  • Jennifer M Feenstra
  • Christina Mundy
  • Raymond P Boot-Handford
  • Joy Kahn
  • Yuriko Kawakami
  • Dmitry Malin
  • Ibolya Kiss
  • Ferenc Deak
  • Markus Schmitz
  • Anja Niehoff
  • Katsuaki Kanbe
  • Gareth Hyde
  • Xu Yang
  • Lei Wei
  • Louise van der Weyden
  • Justin M Allen
  • A R Klatt
  • R Wagener
  • D Segat
  • Kirsten R McDonald
  • Yaping Ko
  • Patrick Smits
  • D Piecha
  • Robert Langer
  • Daphne Heijsman
  • Andreas Kremer
  • Jay Harper
  • Cecilia A Fernandez
  • Arne IJpma
  • Xin Li
  • Peter J van der Spek
  • Andreas R Klatt
  • Roberto Narcisi
  • Mairead Cleary
  • Paul C W Tsang
  • Rene van Weeren
  • Gerjo J V M van Osch
  • Marsha A Moses
  • F Deak
  • Pieter Brama
  • Liu Yang
  • Laszlo G Puskas
  • Erzsebet Kenesi
  • Beáta Boros Oláh
  • Andrew Ghatan
  • Howard A Chansky
  • Andrea Nagy
  • Agnes Zvara
  • Zsolt Csabai
  • Balint Laszlo Balint
  • Colin J Teteak
  • Anna Zielinska-Kwiatkowska
  • Russell J Fernandes
  • Annamaria Molnar
  • Junhui Zou
  • Jacques Hacquebord
  • Laszlo Nagy
  • Charmaine U Pira
  • Katarzyna A Piróg
  • P Smits
  • Richard J Eppey
  • Kohei Kanaya
  • Maryline Fresquet
  • Michael D Briggs
  • Sarah E Hoffman
  • Kerby C Oberg
  • David J Thornton
  • Eiki Koyama
  • Yu Yamaguchi
  • Maurizio Pacifici
  • Motomi Enomoto-Iwamoto
  • Masahiro Iwamoto
  • Tadashi Yasuda
  • Takashi Kinumatsu
  • T Z Ye
  • Eva Sonnenberg-Riethmacher

Detail Information

Publications37

  1. ncbi The transcription factors L-Sox5 and Sox6 are essential for cartilage formation
    P Smits
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Dev Cell 1:277-90. 2001
    ..L-Sox5 and Sox6 are thus redundant, potent enhancers of chondroblast functions, thereby essential for endochondral skeleton formation...
  2. pmc Normal skeletal development of mice lacking matrilin 1: redundant function of matrilins in cartilage?
    A Aszodi
    Department of Experimental Pathology, Lund University, 221 85 Lund, Sweden
    Mol Cell Biol 19:7841-5. 1999
    Matrilin 1, or cartilage matrix protein, is a member of a novel family of extracellular matrix proteins. To date, four members of the family have been identified, but their biological role is unknown...
  3. pmc Lineage tracing using matrilin-1 gene expression reveals that articular chondrocytes exist as the joint interzone forms
    Gareth Hyde
    Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, The University of Manchester, Manchester M13 9PT, UK
    Dev Biol 304:825-33. 2007
    We have developed a mouse in which the Cre recombinase gene has been targeted to exon 1 of the matrilin-1 gene (Matn1) to investigate the origins of articular chondrocytes and the development of the knee joint...
  4. ncbi Abnormal collagen fibrils in cartilage of matrilin-1/matrilin-3-deficient mice
    Claudia Nicolae
    Department of Molecular Medicine, Max Planck Institute for Biochemistry, Martinsried, Germany
    J Biol Chem 282:22163-75. 2007
    ..Surprisingly, however, Matn3-null as well as Matn1- and Matn2-null mice do not show an overt skeletal phenotype, suggesting a dominant negative pathomechanism for ..
  5. pmc Differential gene expression of the intermediate and outer interzone layers of developing articular cartilage in murine embryos
    Florien Jenner
    1 Equine University Hospital, Department of Companion Animals and Horses, University of Veterinary Medicine Vienna, Vienna, Austria
    Stem Cells Dev 23:1883-98. 2014
    ..The high representation of genes relevant to chondrocyte hypertrophy and endochondral ossification in the outer interzone suggests that it undergoes endochondral ossification...
  6. pmc Functional knockout of the matrilin-3 gene causes premature chondrocyte maturation to hypertrophy and increases bone mineral density and osteoarthritis
    Louise van der Weyden
    Mouse Genomics Lab, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom
    Am J Pathol 169:515-27. 2006
    ..However, by 18 weeks of age, Matn3 null mice had a significantly higher total body bone mineral density than Matn1 null mice or wild-type littermates...
  7. pmc Detection of genes regulated by Lmx1b during limb dorsalization
    Jennifer M Feenstra
    Division of Human Anatomy, Department of Pathology and Human Anatomy, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    Dev Growth Differ 54:451-62. 2012
    ..Our study provides the most comprehensive characterization of genes regulated by Lmx1b during limb development to-date and provides targets for further investigation...
  8. doi Hmgb1 can facilitate activation of the matrilin-1 gene promoter by Sox9 and L-Sox5/Sox6 in early steps of chondrogenesis
    Tibor Szénási
    Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, H 6701 Szeged, Hungary Electronic address
    Biochim Biophys Acta 1829:1075-91. 2013
    ..Here we report its contribution to the evolutionarily conserved, distinctive regulation of the matrilin-1 gene (Matn1) expression in amniotes...
  9. pmc Mesenchyme-specific knockout of ESET histone methyltransferase causes ectopic hypertrophy and terminal differentiation of articular chondrocytes
    Kevin A Lawson
    From the Department of Orthopedics and Sports Medicine, University of Washington, Seattle, Washington 98108 and
    J Biol Chem 288:32119-25. 2013
    ....
  10. pmc Matrilin-1 is an inhibitor of neovascularization
    Matthew J Foradori
    From the Program in Vascular Biology and Department of Surgery, Boston Children s Hospital, Boston, Massachusetts 02115 and Harvard Medical School, Boston, Massachusetts 02115
    J Biol Chem 289:14301-9. 2014
    ....
  11. pmc Loss of matrilin 1 does not exacerbate the skeletal phenotype in a mouse model of multiple epiphyseal dysplasia caused by a Matn3 V194D mutation
    Peter A Bell
    University of Manchester, Manchester, UK
    Arthritis Rheum 64:1529-39. 2012
    ..it was proposed that secretion of mutant matrilin 3 may be dependent on the formation of hetero-oligomers with matrilin 1. The aim of this study was to investigate the hypothesis that deletion of matrilin 1 would abolish the formation ..
  12. ncbi Mice lacking matrilin-1 (cartilage matrix protein) have alterations in type II collagen fibrillogenesis and fibril organization
    X Huang
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
    Dev Dyn 216:434-41. 1999
    Matrilin-1 (cartilage matrix protein) is a homotrimeric protein that forms collagen-dependent and collagen-independent fibrils in the extracellular matrix of cartilage...
  13. pmc Synovial joint formation requires local Ext1 expression and heparan sulfate production in developing mouse embryo limbs and spine
    Christina Mundy
    Department of Orthopaedic Surgery, College of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Dev Biol 351:70-81. 2011
    ..The data indicate also that defects in joint formation reverberate on, and delay, overall long bone growth...
  14. doi Muscle contraction is necessary to maintain joint progenitor cell fate
    Joy Kahn
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Dev Cell 16:734-43. 2009
    ..In conclusion, our findings provide the missing link between progenitor cell fate determination and embryonic movement, two processes shown to be essential for correct organogenesis...
  15. doi The extracellular-matrix protein matrilin 2 participates in peripheral nerve regeneration
    Dmitry Malin
    Centre for Molecular Neurobiology, University of Hamburg, D 20251 Hamburg, Germany
    J Cell Sci 122:995-1004. 2009
    ..These results show that matrilin 2 is a permissive substrate for axonal growth and cell migration, and that it is required for successful nerve regeneration...
  16. doi Impaired neurogenesis in embryonic spinal cord of Phgdh knockout mice, a serine deficiency disorder model
    Yuriko Kawakami
    Laboratory of Metabolic Regulation Research, Kyushu University Bio Architecture Center, Fukuoka 812 8581, Japan Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812 8581, Japan
    Neurosci Res 63:184-93. 2009
    ..The present integrative study provides in vivo evidence that normal cell cycle progression and subsequent neurogenesis of radial glia cells are severely impaired by serine deficiency...
  17. ncbi Transgenic mice expressing D469Delta mutated cartilage oligomeric matrix protein (COMP) show growth plate abnormalities and sternal malformations
    Markus Schmitz
    Center for Biochemistry, Medical Faculty, University of Cologne, Joseph Stelzmann Str 52, D 50931 Cologne, Germany
    Matrix Biol 27:67-85. 2008
    ..Later in development, the growth plate was irregularly shaped and prematurely invaded by bony tissue. In addition, a fusion of the third and fourth sternebrae was frequently observed...
  18. pmc The cartilage matrix protein subdomain of type VII collagen is pathogenic for epidermolysis bullosa acquisita
    Mei Chen
    Department of Dermatology, The Keck School of Medicine, University of Southern California, 1303 Mission Road, Los Angeles, CA 90033, USA
    Am J Pathol 170:2009-18. 2007
    ..domain corresponding to the N-terminal 227 amino acids (residues 1 to 227), which contains homology with cartilage matrix protein (CMP)...
  19. ncbi Pericellular matrilins regulate activation of chondrocytes by cyclic load-induced matrix deformation
    Katsuaki Kanbe
    Department of Orthopaedic Surgery, Tokyo Women s Medical University Medical Center East, Japan
    J Bone Miner Res 22:318-28. 2007
    ..Thus, pericellular matrilins may play a role in chondrocyte mechanotransduction...
  20. ncbi Ablation of calcitonin/calcitonin gene-related peptide-alpha impairs fetal magnesium but not calcium homeostasis
    Kirsten R McDonald
    Faculty of Medicine Endocrinology, Memorial University of Newfoundland, St John s, Canada
    Am J Physiol Endocrinol Metab 287:E218-26. 2004
    ..These findings indicate that calcitonin and CGRPalpha are not needed for normal fetal calcium metabolism but may regulate aspects of fetal Mg metabolism...
  21. ncbi Expression of matrilin-1, -2 and -3 in developing mouse limbs and heart
    D Segat
    Institute for Biochemistry, Medical Faculty, University of Cologne, D 50931, Cologne, Germany
    Matrix Biol 19:649-55. 2000
    ..The complementary, but in part overlapping, expression of matrilins indicates the possibility for both redundant and unique functions among the members of this novel family of extracellular matrix proteins...
  22. ncbi Primary structure and expression of matrilin-2, the closest relative of cartilage matrix protein within the von Willebrand factor type A-like module superfamily
    F Deak
    Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, P O Box 521, Szeged H 6701, Hungary
    J Biol Chem 272:9268-74. 1997
    ..A sequence similarity search indicated the closest relation to the trimeric cartilage matrix protein (CMP)...
  23. ncbi Sequence, structure and chromosomal localization of Crtm gene encoding mouse cartilage matrix protein and its exclusion as a candidate for murine achondroplasia
    A Aszodi
    Department of Experimental Pathology, University Hospital, Lund, Sweden
    Matrix Biol 16:563-73. 1998
    The mouse cartilage matrix protein gene (Crtm) was isolated from a cosmid library using a mouse Crtm cDNA fragment as probe. Crtm spans 12.2 kb from the start of translation to the polyadenylation signal sequence and comprises eight exons...
  24. ncbi Disrupted expression of matrix genes in the growth plate of the mouse cartilage matrix deficiency (cmd) mutant
    A W Wai
    Department of Biochemistry, University of Hong Kong, China
    Dev Genet 22:349-58. 1998
    ..The discordance of gene expression in cmd chondrocytes may be additional factors contributing to the disrupted cellular architecture of the growth plate resulting from the primary absence of aggrecan...
  25. pmc Collagen II is essential for the removal of the notochord and the formation of intervertebral discs
    A Aszodi
    Department of Experimental Pathology, Lund University, 22185 Lund, Sweden
    J Cell Biol 143:1399-412. 1998
    ....
  26. pmc Perlecan maintains the integrity of cartilage and some basement membranes
    M Costell
    Department of Experimental Pathology, Lund University, S 221 85 Lund, Sweden
    J Cell Biol 147:1109-22. 1999
    ....
  27. ncbi Distribution of cartilage molecules in the developing mouse joint
    J M Murphy
    Osiris Therapeutics Inc, Baltimore, MD 21231, USA
    Matrix Biol 18:487-97. 1999
    ..of protein distribution for aggrecan, fibromodulin, cartilage oligomeric matrix protein (COMP) and cartilage matrix protein (CMP) in the developing mouse limb with particular attention to those cells destined to form articular ..
  28. ncbi Ermap, a gene coding for a novel erythroid specific adhesion/receptor membrane protein
    T Z Ye
    Department of Pathology and Molecular Medicine, McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada
    Gene 242:337-45. 2000
    ..Northern blot analysis and in-situ hybridization demonstrated that Ermap expression was restricted to fetal and adult erythroid tissues. ERMAP is likely a novel adhesion/receptor molecule specific for erythroid cells...
  29. ncbi The matrilins: a growing family of A-domain-containing proteins
    M Paulsson
    Institute for Biochemistry, Medical Faculty, University of Cologne, Germany
    Biochem Soc Trans 27:824-6. 1999
  30. ncbi WARP is a novel multimeric component of the chondrocyte pericellular matrix that interacts with perlecan
    Justin M Allen
    Cell and Matrix Biology Research Unit, Murdoch Childrens Research Institute and Department of Paediatrics, University of Melbourne, Royal Children s Hospital, Flemington Road, Parkville, Victoria 3052, Australia
    J Biol Chem 281:7341-9. 2006
    ..We conclude that WARP forms macromolecular structures that interact with perlecan to contribute to the assembly and/or maintenance of "permanent" cartilage structures during development and in mature cartilages...
  31. ncbi Molecular structure, processing, and tissue distribution of matrilin-4
    A R Klatt
    Institute for Biochemistry and the Center for Molecular Medicine Cologne Service Laboratory, Medical Faculty, University of Cologne, Joseph Stelzmann Strasse 52, D 50931 Cologne, Germany
    J Biol Chem 276:17267-75. 2001
    ..In the matrix formed by cultured primary embryonic fibroblasts, matrilin-4 is found in a filamentous network connecting individual cells...
  32. ncbi The role of collagen II and cartilage fibril-associated molecules in skeletal development
    A Aszodi
    Department of Experimental Pathology, Lund University, Sweden
    Osteoarthritis Cartilage 9:S150-9. 2001
    ..To understand the role some of these molecules in skeletal development, we have generated transgenic mouse strains harboring ablated genes for collagens II and IX, and matrilin-1...
  33. ncbi Expression of matrilins during maturation of mouse skeletal tissues
    Andreas R Klatt
    Institute for Biochemistry II, Medical Faculty, University of Cologne, Joseph Stelzmann Str 52, D 50931 Cologne, Germany
    Matrix Biol 21:289-96. 2002
    ..During joint development matrilin-2 and matrilin-4 are present at the developing joint surface, while in articular cartilage of 6-week-old mice all matrilins are only weakly expressed...
  34. pmc Matrilin-3 is dispensable for mouse skeletal growth and development
    Yaping Ko
    Center for Biochemistry, Medical Faculty, University of Cologne, D 50931 Cologne, Germany
    Mol Cell Biol 24:1691-9. 2004
    ..Altogether, our findings suggest functional redundancy among matrilins and demonstrate that the phenotypes of MED disorders are not caused by the absence of matrilin-3 in cartilage ECM...
  35. pmc Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate
    Patrick Smits
    Dept of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Ave, ND 20, Cleveland, OH 44195, USA
    J Cell Biol 164:747-58. 2004
    ..In conclusion, Sox5 and Sox6 are needed for the establishment of multilayered growth plates, and thereby for proper and timely development of endochondral bones...
  36. ncbi Cloning, sequencing and expression analysis of mouse cartilage matrix protein cDNA
    A Aszodi
    Institute for Animal Sciences, Agricultural Biotechnology Center, Godollo, Hungary
    Eur J Biochem 236:970-7. 1996
    A cDNA encoding the mouse cartilage matrix protein (CMP) was cloned following the reverse-transcription polymerase chain reaction and rapid amplification of cDNA ends procedures using mRNA isolated from trachea...
  37. ncbi Mice lacking the extracellular matrix adaptor protein matrilin-2 develop without obvious abnormalities
    Lajos Mátés
    Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, H 6701 Szeged, Hungary
    Matrix Biol 23:195-204. 2004
    ....

Research Grants1

  1. Strategies Towards Gene Therapy for Dystrophic Epidermolysis Bullosa
    Mei Chen; Fiscal Year: 2009
    ..We believe the proposed experiments will give us sufficient information to consider clinical protocols for humans, the long-term goal of this work. ..