Mapk14

Summary

Gene Symbol: Mapk14
Description: mitogen-activated protein kinase 14
Alias: CSBP2, Crk1, Csbp1, Mxi2, PRKM14, PRKM15, p38, p38-alpha, p38MAPK, p38a, p38alpha, mitogen-activated protein kinase 14, MAP kinase 14, MAP kinase p38 alpha, MAPK 14, cytokine suppressive anti-inflammatory drug binding protein 1, mitogen-activated protein kinase p38 alpha, p38 MAP kinase alpha, p38 MAPK, p38 alpha, tRNA synthetase cofactor p38
Species: mouse

Top Publications

  1. ncbi Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses
    Ram Kumar Mathur
    National Centre for Cell Science, Ganeshkhind, Pune 411007, India
    Nat Med 10:540-4. 2004
  2. pmc The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression
    Chun Kim
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Nat Immunol 9:1019-27. 2008
  3. pmc Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation
    Ana Cuadrado
    Spanish National Cancer Center CNIO, Madrid, Spain
    EMBO J 29:2014-25. 2010
  4. ncbi Activation of p38 mitogen-activated protein kinase and c-Jun-NH2-terminal kinase by BMP-2 and their implication in the stimulation of osteoblastic cell differentiation
    J Guicheux
    Division of Bone Diseases, Department of Geriatrics, University Hospital of Geneva, Geneva, Switzerland
    J Bone Miner Res 18:2060-8. 2003
  5. pmc Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination
    Debora Bogani
    Mammalian Genetics Unit, Medical Research Council MRC Harwell, Oxfordshire, United Kingdom
    PLoS Biol 7:e1000196. 2009
  6. pmc Cross-talk between the p38alpha and JNK MAPK pathways mediated by MAP kinase phosphatase-1 determines cellular sensitivity to UV radiation
    Christopher J Staples
    CR UK Stress Response Laboratory, Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    J Biol Chem 285:25928-40. 2010
  7. ncbi Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition
    Jin Mo Park
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0636, USA
    Science 297:2048-51. 2002
  8. ncbi Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development
    R H Adams
    European Molecular Biology Laboratory, Heidelberg, Germany
    Mol Cell 6:109-16. 2000
  9. pmc p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes
    Felix B Engel
    Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 19:1175-87. 2005
  10. pmc beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity
    Xi Zhang
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Development 136:3357-66. 2009

Research Grants

Detail Information

Publications196 found, 100 shown here

  1. ncbi Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses
    Ram Kumar Mathur
    National Centre for Cell Science, Ganeshkhind, Pune 411007, India
    Nat Med 10:540-4. 2004
    ..ERK-1/2)-dependent IL-10 expression, whereas stronger signals induce p38 mitogen-activated protein kinase (p38MAPK)-dependent IL-12 production. p38MAPK and ERK-1/2 therefore have counter-regulatory actions...
  2. pmc The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression
    Chun Kim
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Nat Immunol 9:1019-27. 2008
    ..Among the many p38 isoforms, p38 alpha is the most widely expressed in adult tissues and can be targeted by various pharmacological inhibitors...
  3. pmc Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation
    Ana Cuadrado
    Spanish National Cancer Center CNIO, Madrid, Spain
    EMBO J 29:2014-25. 2010
    ..We show that the SRCAP subunit named ZNHIT1 or p18(Hamlet), which is a substrate of p38 MAPK, is recruited to the myogenin promoter at the onset of muscle differentiation, in a p38 MAPK-dependent manner...
  4. ncbi Activation of p38 mitogen-activated protein kinase and c-Jun-NH2-terminal kinase by BMP-2 and their implication in the stimulation of osteoblastic cell differentiation
    J Guicheux
    Division of Bone Diseases, Department of Geriatrics, University Hospital of Geneva, Geneva, Switzerland
    J Bone Miner Res 18:2060-8. 2003
    ..We report that BMP-2 can activate JNK and p38 in osteoblastic cells and provide evidences that these MAP kinases have distinct roles in regulating alkaline ..
  5. pmc Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination
    Debora Bogani
    Mammalian Genetics Unit, Medical Research Council MRC Harwell, Oxfordshire, United Kingdom
    PLoS Biol 7:e1000196. 2009
    ..Moreover, we describe experiments showing the presence of activated MKK4, a direct target of MAP3K4, and activated p38 in the coelomic region of the XY gonad at 11...
  6. pmc Cross-talk between the p38alpha and JNK MAPK pathways mediated by MAP kinase phosphatase-1 determines cellular sensitivity to UV radiation
    Christopher J Staples
    CR UK Stress Response Laboratory, Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    J Biol Chem 285:25928-40. 2010
    ..The induction of DUSP1/MKP-1 mRNA and protein in response to UV radiation is mediated by activation of the p38alpha but not the JNK1 or JNK2 MAPK pathways...
  7. ncbi Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition
    Jin Mo Park
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0636, USA
    Science 297:2048-51. 2002
    ..This dismantling of the p38 MAPK module represents a strategy used by B. anthracis to paralyze host innate immunity.
  8. ncbi Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development
    R H Adams
    European Molecular Biology Laboratory, Heidelberg, Germany
    Mol Cell 6:109-16. 2000
    b>p38alpha MAP kinase is activated in response to many cellular stresses and also regulates the differentiation and/or survival of various cell types in vitro, including skeletal muscle cells and cardiomyocytes...
  9. pmc p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes
    Felix B Engel
    Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 19:1175-87. 2005
    ..6%. In contrast, cardiac-specific p38alpha knockout mice show a 92.3% increase in neonatal cardiomyocyte mitoses...
  10. pmc beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity
    Xi Zhang
    Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Development 136:3357-66. 2009
    ..Thus beta1 integrins can regulate organ branching morphogenesis during development by mediating growth-factor-dependent signaling in addition to their well-defined role as adhesion receptors...
  11. pmc p38 regulates expression of osteoblast-specific genes by phosphorylation of osterix
    María José Ortuño
    Departament de Ciències Fisiològiques II, Universitat de Barcelona, Institut d Investigació Biomèdica de Bellvitge IDIBELL, E 08907 L Hospitalet de Llobregat, Spain
    J Biol Chem 285:31985-94. 2010
    ..Furthermore, we show that Osterix is a novel substrate for p38 MAPK in vitro and in vivo and that Ser-73 and Ser-77 are the regulatory sites phosphorylated by p38...
  12. doi A male-specific role for p38 mitogen-activated protein kinase in germ cell sex differentiation in mice
    Katherine Ewen
    Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia
    Biol Reprod 83:1005-14. 2010
    ..We report that p38 MAPK is phosphorylated and therefore activated only in XY germ cells around the time of sex differentiation...
  13. ncbi Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for activation of p38alpha and p38delta MAPK isoforms by TGF-beta 1 in murine mesangial cells
    Lin Wang
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 277:47257-62. 2002
    ..TGF-beta1 selectively activated the p38 MAPK isoforms p38alpha and p38delta in wild-type (Mkk3+/+) mesangial cells, but not in MKK3-deficient (Mkk3-/-) mesangial cells...
  14. ncbi A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
    J Han
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037
    Science 265:808-11. 1994
    ..A protein kinase, p38, that was tyrosine phosphorylated in response to LPS, was cloned...
  15. pmc The dual-specificity protein phosphatase DUSP9/MKP-4 is essential for placental function but is not required for normal embryonic development
    Graham R Christie
    Cancer Research UK Molecular Pharmacology Unit, Biomedical Research Centre, Level 5, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, United Kingdom
    Mol Cell Biol 25:8323-33. 2005
    ....
  16. ncbi Murine p38-delta mitogen-activated protein kinase, a developmentally regulated protein kinase that is activated by stress and proinflammatory cytokines
    M C Hu
    Department of Cell Biology, Amgen, Inc, Thousand Oaks, California 91320, USA
    J Biol Chem 274:7095-102. 1999
    The p38 mitogen-activated protein kinases (MAPK) play a crucial role in stress and inflammatory responses and are also involved in activation of the human immunodeficiency virus gene expression...
  17. ncbi Activation of p38 mitogen-activated protein kinase is required for osteoblast differentiation
    Yuanyu Hu
    Institute of Molecular and Cell Biology, National University of Singapore, Singapore 117609
    Endocrinology 144:2068-74. 2003
    b>p38 MAPK is a conserved subfamily of MAPKs involved in inflammatory response, stress response, cell growth and survival, as well as differentiation of a variety of cell types...
  18. ncbi Roles of JNK-1 and p38 in selective induction of apoptosis by capsaicin in ras-transformed human breast epithelial cells
    Hye Jung Kang
    College of Pharmacy, Duksung Women s University, 4129 Ssangmun dong, Tobong ku, Seoul 132 714, Korea
    Int J Cancer 103:475-82. 2003
    ..In H-ras MCF10A cells, capsaicin treatment markedly activated c-Jun N-terminal protein kinase (JNK)-1 and p38 matigen-activated protein kinase (MAPK) while it deactivated extracellular signal-regulated protein kinases (ERKs)...
  19. pmc Interleukin-3 stimulation of mcl-1 gene transcription involves activation of the PU.1 transcription factor through a p38 mitogen-activated protein kinase-dependent pathway
    Ju Ming Wang
    Institute of Molecular Biology, Academia Sinica, 128 Yen Jiou Yuan Road, Section 2, Nankang, Taipei 11529, Taiwan, Republic of China
    Mol Cell Biol 23:1896-909. 2003
    ..The latter effect coincides with the increased phosphorylation of PU.1 following IL-3 activation of a p38 mitogen-activated protein kinase (p38(MAPK))-dependent pathway...
  20. pmc p38 alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failure
    Jan Heinrichsdorff
    Institute for Genetics, Centre for Molecular Medicine CMMC, and Cologne Excellence Cluster on Cellular Stress Responses in Aging associated Diseases CECAD, University of Cologne, Zülpicher Str 47, D 50674 Cologne, Germany
    EMBO Rep 9:1048-54. 2008
    ..Here, we show that hepatocyte-specific ablation of p38alpha in mice results in excessive activation of JNK in the liver after in vivo challenge with bacterial ..
  21. doi Inhibition and genetic deficiency of p38 MAPK up-regulates heme oxygenase-1 gene expression via Nrf2
    Srivatsava Naidu
    Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University Giessen, Giessen, Germany
    J Immunol 182:7048-57. 2009
    ..basal HO-1 gene expression levels were markedly higher in untreated murine embryonic fibroblasts (MEF) from p38alpha(-/-) mice compared with those from wild-type mice...
  22. pmc Inhibitor of NF-kappa B kinases alpha and beta are both essential for high mobility group box 1-mediated chemotaxis [corrected]
    Marianna Penzo
    Vita Salute San Raffaele University, School of Medicine, San Raffaele Scientific Institute, Milano, Italy
    J Immunol 184:4497-509. 2010
    ..Thus, proinflammatory HMGB1 chemotactic responses mechanistically require the differential collaboration of both IKK-dependent NF-kappaB signaling pathways...
  23. pmc Myocardial adenosine A(1)-receptor-mediated adenoprotection involves phospholipase C, PKC-epsilon, and p38 MAPK, but not HSP27
    Richard A Fenton
    Dept of Physiology, Univ of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Am J Physiol Heart Circ Physiol 298:H1671-8. 2010
    ..In a second study, p38 MAPK and heat shock protein 27 (HSP27), found by others to be associated with the loss of myocardial contractile ..
  24. doi Leptin regulates MMP-2, TIMP-1 and collagen synthesis via p38 MAPK in HL-1 murine cardiomyocytes
    Kristin Schram
    Department of Biology, York University, Toronto, Canada
    Cell Mol Biol Lett 15:551-63. 2010
    ..Leptin is known to stimulate phosphorylation of p38 MAPK in cardiac cells and utilization of the p38 MAPK inhibitor, SB203580, demonstrated that this kinase also plays a ..
  25. doi Macrophage-derived BAFF induces AID expression through the p38MAPK/CREB and JNK/AP-1 pathways
    Hyun A Kim
    Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 200 701, Republic of Korea
    J Leukoc Biol 89:393-8. 2011
    ..Subsequent analysis of BAFF signaling suggested that BAFF induces AID through BCMA, a BAFF-receptor, and p38MAPK and CREB act as intermediates in AID expression. In addition, JNK and AP-1 have similar activities...
  26. pmc Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis
    J S Mudgett
    Merck Research Laboratories, Rahway, NJ 07065, USA
    Proc Natl Acad Sci U S A 97:10454-9. 2000
    ..mediates signaling in response to environmental stresses and inflammatory cytokines, but the requirements for the p38 MAPK pathway in normal mammalian development have not been elucidated...
  27. ncbi ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity
    Atsushi Matsuzawa
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Nat Immunol 6:587-92. 2005
    ..kinase 1 (ASK1) is an evolutionarily conserved mitogen-activated protein 3-kinase that activates both Jnk and p38 mitogen-activated protein kinases...
  28. ncbi Heme oxygenase-1-derived carbon monoxide requires the activation of transcription factor NF-kappa B to protect endothelial cells from tumor necrosis factor-alpha-mediated apoptosis
    Sophie Brouard
    Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:17950-61. 2002
    ..This effect relies on the activation of p38 MAPK. We now demonstrate that HO-1/CO requires the activation of the transcription factor NF-kappaB to exert this anti-..
  29. doi Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation
    Hayato Nakagawa
    Department of Gastroenterology, University of Tokyo, Hongo, Bunkyo ku, Tokyo
    Gastroenterology 135:1311-21. 2008
    ..We tested the hypothesis that ASK1 was involved in APAP-induced JNK activation and liver injury...
  30. ncbi Inhibition of p38 MAP kinase- and RICK/NF-kappaB-signaling suppresses inflammatory bowel disease
    Eike Hollenbach
    Institute of Experimental Internal Medicine, Otto von Guericke University, Magdeburg, Germany
    FASEB J 18:1550-2. 2004
    ..The goal of this study was to evaluate the effects of the p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580 on inflammatory responses using the DSS-induced ..
  31. ncbi Mechanical stress activates xanthine oxidoreductase through MAP kinase-dependent pathways
    Raja Elie E Abdulnour
    Division of Pulmonary and Critical Care Medicine, Bloomberg School of Public Health, Baltimore, Maryland, USA
    Am J Physiol Lung Cell Mol Physiol 291:L345-53. 2006
    ..There was evidence of p38 MAP kinase, ERK1/2, and ERK5 phosphorylation, but no change in JNK phosphorylation...
  32. pmc A Cdo-Bnip-2-Cdc42 signaling pathway regulates p38alpha/beta MAPK activity and myogenic differentiation
    Jong Sun Kang
    Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Cell Biol 182:497-507. 2008
    The p38alpha/beta mitogen-activated protein kinase (MAPK) pathway promotes skeletal myogenesis, but the mechanisms by which it is activated during this process are unclear...
  33. doi Increased endothelial mitogen-activated protein kinase phosphatase-1 expression suppresses proinflammatory activation at sites that are resistant to atherosclerosis
    Mustafa Zakkar
    British Heart Foundation Cardiovascular Sciences Unit, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    Circ Res 103:726-32. 2008
    ..induce adhesion molecules (eg, vascular cell adhesion molecule [VCAM]-1) in endothelial cells (ECs) by activating p38 and c-Jun N-terminal kinase (JNK) mitogen-activated protein (MAP) kinases by phosphorylation...
  34. pmc Distinct effects of p38alpha deletion in myeloid lineage and gut epithelia in mouse models of inflammatory bowel disease
    Motoyuki Otsuka
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92307, USA
    Gastroenterology 138:1255-65, 1265.e1-9. 2010
    b>p38Alpha is a mitogen-activated protein kinase that mediates inflammatory responses, but its role in inflammatory bowel disease is unclear...
  35. doi p38MAPK controls expression of multiple cell cycle inhibitors and islet proliferation with advancing age
    Esther Sook Miin Wong
    Institute of Molecular and Cell Biology, Proteos, Singapore
    Dev Cell 17:142-9. 2009
    ..Little is known, however, about the upstream signals that induce their expression. Here, we explore the role of p38MAPK by generating a dominant-negative allele (p38(AF)) in which activating phosphorylation sites Thr180 and Tyr182 ..
  36. pmc A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase
    C Blanco-Aparicio
    Instituto de Investigaciones Citologicas, 46010 Valencia, Spain
    J Cell Biol 147:1129-36. 1999
    ..binding and tyrosine dephosphorylation of the MAP kinases extracellular signal-regulated kinase (ERK)1/2 and p38alpha were impaired...
  37. ncbi Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation
    Koichi Obata
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Hyogo 663 8501, Japan
    J Neurosci 24:10211-22. 2004
    ..partial nerve injury, we examined the phosphorylation of extracellular signal-regulated protein kinase (ERK), p38 MAPK, and c-Jun N-terminal kinase (JNK) in the L4 and L5 dorsal root ganglion (DRG) in the L5 spinal nerve ligation (..
  38. pmc E47 phosphorylation by p38 MAPK promotes MyoD/E47 association and muscle-specific gene transcription
    Frederic Lluis
    Center for Genomic Regulation, Program on Differentiation and Cancer, Barcelona, Spain
    EMBO J 24:974-84. 2005
    ..Here we show that p38 MAPK, whose activity is essential for myogenesis, regulates MyoD/E47 heterodimerization...
  39. ncbi Requirement of the MAP kinase signaling pathways for mouse preimplantation development
    Momoko Maekawa
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Development 132:1773-83. 2005
    ..Our results show that inhibition of the JNK pathway or of the p38 MAP kinase pathway, but not of the ERK pathway, results in inhibition of cavity formation, and that JNK and p38 are ..
  40. ncbi Genetic deficiency of p38alpha reveals its critical role in myoblast cell cycle exit: the p38alpha-JNK connection
    Eusebio Perdiguero
    Program on Differentiation and Cancer, Centre for Genomic Regulation, UPF PRBB, CIBER de Enfermedades Neurodegenerativas, Barcelona, Spain
    Cell Cycle 6:1298-303. 2007
    ..However, the relative contribution of the four p38 MAP kinases (p38alpha, p38beta, p38gamma and p38delta) to this process was unknown...
  41. pmc Macrophage deficiency of p38alpha MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice
    Tracie A Seimon
    Department of Medicine, Division of Molecular Medicine, Columbia University, PH 9 405, 630 W 168th Street, New York, New York 10032, USA
    J Clin Invest 119:886-98. 2009
    ..Here we placed Apoe-/- mice deficient in macrophage p38alpha MAPK on a Western diet and found that they had a marked increase in macrophage apoptosis and plaque necrosis...
  42. pmc Characterization of a murine gene encoding a developmentally regulated cytoplasmic dual-specificity mitogen-activated protein kinase phosphatase
    Robin J Dickinson
    Cancer Research UK, Molecular Pharmacology Unit, Biomedical Research Centre, Ninewells Hospital, Dundee DD1 9SY, Scotland, U K
    Biochem J 364:145-55. 2002
    ..extracellular signal-regulated kinases (ERKs) 1 and 2 and, to a lesser extent, the stress-activated MAPK p38alpha. These properties define the ability of this enzyme to dephosphorylate and inactivate ERK1/2 and p38alpha, but ..
  43. pmc Negative feedback regulation of MKK6 mRNA stability by p38alpha mitogen-activated protein kinase
    Concetta Ambrosino
    European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Mol Cell Biol 23:370-81. 2003
    ..The most abundant and broadly expressed p38 MAP kinase is p38alpha, which can also control the proliferation, differentiation, and survival of several cell types...
  44. pmc Catalytic activation of mitogen-activated protein (MAP) kinase phosphatase-1 by binding to p38 MAP kinase: critical role of the p38 C-terminal domain in its negative regulation
    D Hutter
    Stress Signaling Unit, Laboratory of Cellular and Molecular Biology, National Institute on Aging, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Biochem J 352:155-63. 2000
    ..Here we have shown that MKP-1 associates directly with p38 MAP kinase both in vivo and in vitro, and that this interaction enhances the catalytic activity of MKP-1...
  45. ncbi Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1
    Eva Pålsson McDermott
    Department of Biochemistry and Biotechnology Institute, Trinity College, Dublin 2, Ireland
    J Biol Chem 277:7808-15. 2002
    ..Here we have further investigated the role of Ras and Rap in p38 MAPK activation by IL-1...
  46. ncbi Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1)
    Kerstin Piechotta
    Department of Anesthesiology and Center for Molecular Neuroscience, Vanderbilt University, Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 277:50812-9. 2002
    ..We conclude that several cation chloride co-transporters interact with SPAK and/or OSR1, and we hypothesize that this interaction might play a role during the initiation of the cellular stress response...
  47. pmc p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene
    Wenhong Cao
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 24:3057-67. 2004
    ..receptor gamma (PPARgamma) coativator 1alpha (PGC-1alpha), members of two distinct nuclear factor families, p38 MAPK controls the expression of the UCP1 gene through their respective interactions with a cAMP response element and a ..
  48. ncbi Role of NF-kappaB and p38 MAP kinase signaling pathways in the lipopolysaccharide-dependent activation of heme oxygenase-1 gene expression
    Nastiti Wijayanti
    Institut fur Klinische Chemie und Pathobiochemie, Justus Liebig Universitat Giessen, D 35392 Giessen, Germany
    Antioxid Redox Signal 6:802-10. 2004
    ..The results suggest that the NF-kappaB and p38 MAPK signaling pathways mediate the LPS-dependent induction of HO-1 gene expression via DNA sequences of the proximal ..
  49. ncbi The role of mitogen-activated protein kinase phosphatase-1 in the response of alveolar macrophages to lipopolysaccharide: attenuation of proinflammatory cytokine biosynthesis via feedback control of p38
    Qun Zhao
    Center for Developmental Pharmacology and Toxicology, Children s Research Institute, Children s Hospital, Department of Pediatrics, The Ohio State University, Columbus, Ohio 43205, USA
    J Biol Chem 280:8101-8. 2005
    ..We found that LPS triggered transient activation of three MAP kinase subfamilies, ERK, JNK, and p38, in both immortalized and primary murine alveolar macrophages...
  50. ncbi p38 mitogen-activated protein kinase (MAPK) first regulates filamentous actin at the 8-16-cell stage during preimplantation development
    Andrew J M Paliga
    Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada N6A 5C1
    Biol Cell 97:629-40. 2005
    ..protein kinases (JNK/SAPK); the ERKs (extracellular-signal-regulated kinases); the ERK5 or big MAPK1; and the p38 MAPK group of protein kinases, all of which are highly conserved...
  51. pmc Caveolin-1 confers antiinflammatory effects in murine macrophages via the MKK3/p38 MAPK pathway
    Xiao Mei Wang
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, 3459 Fifth Avenue, MUH 628, Pittsburgh, PA 15213, USA
    Am J Respir Cell Mol Biol 34:434-42. 2006
    ..Taken together, our data suggest that caveolin-1 acts as a potent immunomodulatory effector molecule in immune cells and that the regulation of LPS-induced cytokine production by caveolin-1 involves the MKK3/p38 MAPK pathway.
  52. ncbi p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts
    Paola Briata
    Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Mol Cell 20:891-903. 2005
    ..Here, we demonstrate that p38 alpha and beta isoforms also control muscle-gene expression posttranscriptionally, by stabilizing critical myogenic ..
  53. pmc c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity
    Ewa Stepniak
    Research Institute of Molecular Pathology IMP, A 1030 Vienna, Austria
    Genes Dev 20:2306-14. 2006
    ..Importantly, conditional deletion of p38alpha in livers of c-jun (Deltali*) mice fully restored hepatocyte proliferation and attenuated increased p21 protein ..
  54. pmc Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer
    Babak Oskouian
    Children s Hospital Oakland Research Institute Center for Cancer Research, Oakland, CA 94609 1673, USA
    Proc Natl Acad Sci U S A 103:17384-9. 2006
    ..This effect seemed to be independent of ceramide generation but required SPL enzymatic activity and the actions of p38 MAP kinase, p53, p53-inducible death domain protein (PIDD), and caspase-2 as shown by molecular and chemical ..
  55. ncbi Convergence of Igf2 expression and adhesion signalling via RhoA and p38 MAPK enhances myogenic differentiation
    Fiona A Lovett
    The Babraham Institute, Babraham Research Campus, Cambridge, CB2 4AT, UK
    J Cell Sci 119:4828-40. 2006
    ..PI3-K and p38 MAPK are both essential for successful myogenesis...
  56. ncbi Cytokine-like 1 (Cytl1) regulates the chondrogenesis of mesenchymal cells
    Jae Sung Kim
    Department of Life Sciences, Research Center for Biomolecular Nanotechnology, Gwangju Institute of Science and Technology, Gwangju 500 712, Korea
    J Biol Chem 282:29359-67. 2007
    ..Thus, our results collectively suggest that chondrocyte-specific Cytl1 regulates chondrogenesis as a novel autocrine factor, but not hypertrophic maturation of chondrocytes during cartilage development...
  57. ncbi Transforming growth factor-beta-activated protein kinase 1-binding protein (TAB)-1alpha, but not TAB1beta, mediates cytokine-induced p38 mitogen-activated protein kinase phosphorylation and cell death in insulin-producing cells
    Natalia Makeeva
    Department of Medical Cell Biology, Uppsala University, S 75123 Uppsala, Sweden
    Endocrinology 149:302-9. 2008
    Previous studies have indicated that the p38 MAPK participates in signaling events that lead to the death of the insulin-producing beta-cell...
  58. pmc Phosphorylation of fibroblast growth factor (FGF) receptor 1 at Ser777 by p38 mitogen-activated protein kinase regulates translocation of exogenous FGF1 to the cytosol and nucleus
    Vigdis Sørensen
    Centre for Cancer Biomedicine, Faculty Division Norwegian Radium Hospital, University of Oslo, Oslo, Norway
    Mol Cell Biol 28:4129-41. 2008
    ..translocation was inhibited after chemical inhibition of p38 MAPK or after small interfering RNA knockdown of p38alpha. Translocation was increased after stimulation of p38 MAPK with anisomycin, mannitol, or H2O2...
  59. pmc Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis
    Toshiharu Sakurai
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Cancer Cell 14:156-65. 2008
    ..We examined whether hepatocyte p38 alpha, found to inhibit liver carcinogenesis, acts similarly to IKK beta in control of ROS metabolism and cell death...
  60. pmc Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcus
    Sybille Kenzel
    Center for Pediatric and Adolescent Medicine, University Medical Center Freiburg, Freiburg, Germany
    Infect Immun 77:2474-81. 2009
    ..GBS-induced, MyD88-dependent phosphorylation of the mitogen-activated protein kinase p38 activated the transcription factor AP-1 and early growth response factor 1 (Egr-1) but not NF-kappaB...
  61. pmc Target gene specificity of USF-1 is directed via p38-mediated phosphorylation-dependent acetylation
    Sébastien Corre
    Signaling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted RH8 OTL, United Kingdom
    J Biol Chem 284:18851-62. 2009
    ..Following UV irradiation, USF-1 is phosphorylated by the p38 stress-activated kinase on threonine 153 and directly up-regulates expression of the POMC, MC1R, TYR, TYRP-1 and ..
  62. pmc A chemical genetic approach reveals that p38alpha MAPK activation by diphosphorylation aggravates myocardial infarction and is prevented by the direct binding of SB203580
    Sarawut Kumphune
    King s College London British Heart Foundation Centre, Cardiovascular Division, The Rayne Institute and StThomas Hospital, London SE1 7EH, United Kingdom
    J Biol Chem 285:2968-75. 2010
    ..We addressed these controversies by using mice in which the p38alpha alleles were targeted to cause substitution of the gatekeeper residue and resistance to inhibition...
  63. pmc The structure of mitogen-activated protein kinase p38 at 2.1-A resolution
    Z Wang
    Department of Biochemistry and Biophysics, University of Texas Southwestern Medical Center at Dallas, 75235, USA
    Proc Natl Acad Sci U S A 94:2327-32. 1997
    The structure of mitogen-activated protein (MAP) kinase p38 has been solved at 2.1-A to an R factor of 21.0%, making p38 the second low activity MAP kinase solved to date...
  64. ncbi Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes
    T Sugawara
    Department of Immunology, Institute of Basic Medical Sciences, University of Tsukuba, Japan
    Immunity 9:565-74. 1998
    ..We also show that the MKK6-p38 signaling pathway is critically involved in inducing negative selection of thymocytes...
  65. pmc Deficiency of the stress kinase p38alpha results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells
    M Allen
    Department of Respiratory, Allergy, Immunology, Inflammation, and Infectious Diseases, Central Research, Pfizer, Inc, Groton, CT 06340, USA
    J Exp Med 191:859-70. 2000
    ..A genetic approach was employed to inactivate the gene encoding one p38 isoform, p38alpha. Mice null for the p38alpha allele die during embryonic development...
  66. ncbi Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway
    C Tournier
    Howard Hughes Medical Institute, Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 288:870-4. 2000
    ..These data indicate that mitochondria are influenced by proapoptotic signal transduction through the JNK pathway...
  67. pmc p38 Mitogen-activated protein kinase-, calcium-calmodulin-dependent protein kinase-, and calcineurin-mediated signaling pathways transcriptionally regulate myogenin expression
    Qing Xu
    Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, People s Republic of China
    Mol Biol Cell 13:1940-52. 2002
    ..as an important transcriptional target under the control of three intracellular signaling pathways, namely, the p38 mitogen-activated protein kinase- (MAPK), calcium-calmodulin-dependent protein kinase- (CaMK), and calcineurin-..
  68. pmc Innate recognition of bacteria by a macrophage cytosolic surveillance pathway
    MARY O'RIORDAN
    Department of Molecular and Cell Biology, School of Public Health, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 99:13861-6. 2002
    ..signaling is associated with translocation of NF-kappaB into the nucleus and phosphorylation of the p38 mitogen-activated protein (MAP) kinase...
  69. ncbi Selective suppression of neutrophil accumulation in ongoing pulmonary inflammation by systemic inhibition of p38 mitogen-activated protein kinase
    Jerry A Nick
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 169:5260-9. 2002
    ..Inhibition of p38 MAPK before exposing a cell to stress stimuli has profound anti-inflammatory effects, but little is known about the ..
  70. pmc JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors
    Clement M Lee
    Fels Institute for Cancer Research and Molecular Biology, School of Medicine, Temple University, Philadelphia, PA 19140, USA
    Proc Natl Acad Sci U S A 99:14189-94. 2002
    ..acts as a scaffolding protein to bring together Max and c-Myc along with JNK (c-Jun NH2-terminal kinase) and p38MAPK, as well as their upstream kinases MKK4 (MAPK kinase 4) and MEKK3 (MAPK kinase kinase 3)...
  71. ncbi The effect of aging on p38 signaling pathway activity in the mouse liver and in response to ROS generated by 3-nitropropionic acid
    Ching Chyuan Hsieh
    Department of Human Biological Chemistry and Genetics, The University of Texas Medical Branch, 613 Basic Sci Bldg, Rt 0643, Galveston, TX 77555 0643, USA
    Mech Ageing Dev 123:1423-35. 2002
    ..aging affects the response of the p38 alpha signaling pathway to 3-NPA...
  72. ncbi Disruption of a single copy of the p38alpha MAP kinase gene leads to cardioprotection against ischemia-reperfusion
    Kinya Otsu
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 302:56-60. 2003
    ..We examined the role of p38alpha in ischemia-reperfusion injury by studying p38alpha(+/-) mice...
  73. pmc Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha
    Peter C F Cheung
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, Dow Street, University of Dundee, Dundee DD1 5EH, UK
    EMBO J 22:5793-805. 2003
    TAB1, a subunit of the kinase TAK1, was phosphorylated by SAPK2a/p38alpha at Ser423, Thr431 and Ser438 in vitro...
  74. ncbi Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo
    Robert A Kaiser
    Department of Pediatrics, University of Cincinnati, Children s Hospital Medical Center, Division of Molecular Cardiovascular Biology, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 279:15524-30. 2004
    ..p38 vectors reduced apoptosis induced by 2-deoxyglucose treatment, whereas overexpression of wild-type p38alpha or an activated mitogen-activated protein kinase kinase (MKK)6 mutant each enhanced cell death...
  75. ncbi Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway
    Dmitry V Bulavin
    Gene Response Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 36:343-50. 2004
    ..encoding Wip1 phosphatase activated the p53 and p16 (also called Ink4a)-p19 (also called ARF) pathways through p38 MAPK signaling and suppressed in vitro transformation of mouse embryo fibroblasts (MEFs) by oncogenes...
  76. ncbi Streptococcus pneumoniae-induced p38 MAPK-dependent phosphorylation of RelA at the interleukin-8 promotor
    Bernd Schmeck
    Department of Internal Medicine Infectious Diseases, Charite, University Medicine Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    J Biol Chem 279:53241-7. 2004
    ..The present study shows that NF-kappaB and p38 MAPK signaling pathways contribute to chemokine synthesis by lung epithelial cells in response to pneumococci...
  77. pmc p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload
    Kazuhiko Nishida
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Mol Cell Biol 24:10611-20. 2004
    ..The mitogen-activated protein kinase p38alpha is a key component of stress response pathways in various types of cells...
  78. ncbi Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light
    Tamara Tanos
    Laboratorio de Fisiologia y Biologia Molecular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IFIBYNE CONICET, 1428 Buenos Aires, Argentina
    J Biol Chem 280:18842-52. 2005
    ..Using a specific pharmacological inhibitor for p38alpha and -beta, we found that most likely these two isoforms mediate UV-induced c-Fos phosphorylation in vivo...
  79. ncbi Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases
    Jesus M Salvador
    Gene Response Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 6:390-5. 2005
    ..Here we show that T cells stimulated through the T cell receptor (TCR) used an alternative mechanism in which p38 was phosphorylated on Tyr323 and subsequently autophosphorylated residues Thr180 and Tyr182...
  80. ncbi Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway
    Takayuki Akimoto
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 280:19587-93. 2005
    ..transient increase of Pgc-1alpha mRNA expression in mouse plantaris muscle, concurrent with an activation of the p38 MAPK pathway...
  81. pmc Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways
    Nyaya Kelkar
    Howard Hughes Medical Institute, Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation St, Worcester, MA 01605, USA
    Mol Cell Biol 25:2733-43. 2005
    ..Specifically, JIP4 does not activate JNK signaling. In contrast, JIP4 serves as an activator of the p38 mitogen-activated protein (MAP) kinase pathway by a mechanism that requires the MAP kinase kinases MKK3 and MKK6...
  82. pmc The p38alpha/beta MAPK functions as a molecular switch to activate the quiescent satellite cell
    Nathan C Jones
    Bayer Corporation, Research Triangle Park, NC 27709, USA
    J Cell Biol 169:105-16. 2005
    ..Here, we report that the p38alpha/beta family of mitogen-activated protein kinases (MAPKs) reversibly regulates the quiescent state of the skeletal ..
  83. ncbi A novel isoform of Vinexin, Vinexin gamma, regulates Sox9 gene expression through activation of MAPK cascade in mouse fetal gonad
    Makoto Matsuyama
    Division of Sex Differentiation, National Institute for Basic Biology, Okazaki 444 8787, Japan
    Genes Cells 10:421-34. 2005
    ..Thus, Vinexin gamma seems to be implicated in regulation of Sox9 gene expression by modulating MAPK cascade in mouse fetal gonads...
  84. ncbi Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes
    Axel Thiefes
    Institute of Pharmacology, Medical School Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    J Biol Chem 280:27728-41. 2005
    ..Expression of this protein inhibited tumor necrosis factor (TNF)-induced activation of NFkappaB, JNK, and p38 MAPK and sensitized the cells to TNF-induced apoptosis...
  85. ncbi Regulation of vertebrate myotome development by the p38 MAP kinase-MEF2 signaling pathway
    Luciana De Angelis
    Istituto di Istologia ed Embriologia Generale, Universita di Roma La Sapienza, Via A Scarpa 14, 00161 Rome, Italy
    Dev Biol 283:171-9. 2005
    ..Here, we report a critical interaction between the p38 mitogen-activated protein kinase (p38 MAPK) and MEF2 in the developing somite myotome...
  86. ncbi Role of p38 MAPK in UVB-induced inflammatory responses in the skin of SKH-1 hairless mice
    Arianna L Kim
    Department of Dermatology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Invest Dermatol 124:1318-25. 2005
    ..We assessed the effects of ultraviolet B (UVB) on the p38 MAPK pathway and determined whether cyclooxygenase (COX)-2 expression is downstream of this kinase in the skin of UVB-..
  87. ncbi Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators
    Jin Mo Park
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA
    Immunity 23:319-29. 2005
    ..with the TLR4-activating bacterium Bacillus anthracis triggers an apoptotic response due to inhibition of p38 MAP kinase activation by the bacterial-produced lethal toxin...
  88. pmc Constitutive activation of MKK6 in chondrocytes of transgenic mice inhibits proliferation and delays endochondral bone formation
    Ren Zhang
    Department of Molecular Genetics, Graduate Program in Genes and Development, University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:365-70. 2006
    ..Therefore, our study provides in vivo evidence for the role of p38 in endochondral ossification and suggests that Sox9 is a likely downstream target of the p38 MAPK pathway.
  89. ncbi p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation
    Irene E Zohn
    Howard Hughes Medical Institute, Department of Pediatrics, Section of Developmental Biology, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    Cell 125:957-69. 2006
    ..We demonstrate that p38 MAP kinase and a p38-interacting protein (p38IP) are critically required for downregulation of E-cadherin during ..
  90. ncbi Negative regulation of Akt activity by p38alpha MAP kinase in cardiomyocytes involves membrane localization of PP2A through interaction with caveolin-1
    Susana Zuluaga
    Departamento de Bioquimica y Biologia Molecular II, Facultad de Farmacia, UCM, Ciudad Universitaria, 28040 Madrid, Spain
    Cell Signal 19:62-74. 2007
    Cardiomyocyte-derived cell lines deficient in p38alpha are more resistant to apoptosis owing to lower expression of the pro-apoptotic proteins Bax and Fas and upregulation of the ERK survival pathway...
  91. ncbi Feedback control of MKP-1 expression by p38
    Jun Hao Hu
    Signal Transduction Lab of Institute of Health Sciences, Shanghai Institutes for Biological Sciences corrected Chinese Academy of Sciences and corrected Shanghai Jiao Tong University School of Medicine, China
    Cell Signal 19:393-400. 2007
    ..Thus, p38 MAPK plays a critical role in mediating expression of MKP-1 at a post-transcriptional level...
  92. ncbi Activation of the Mitf promoter by lipid-stimulated activation of p38-stress signalling to CREB
    Bidisha Saha
    Department of Cellular Biochemistry, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Jadavpur, Kolkata 700 032, India
    Pigment Cell Res 19:595-605. 2006
    ..Here we show that the Mitf promoter is induced by lipid signalling via the p38 stress-activated kinase pathway that is also activated by a wide range of receptors as well as UV irradiation...
  93. pmc p38 kinase regulates epidermal growth factor receptor downregulation and cellular migration
    Mark R Frey
    Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Vanderbilt University School of Medicine, 2215 Garland Avenue, Nashville, TN 37232, USA
    EMBO J 25:5683-92. 2006
    ..Using pharmacological and RNA interference inhibition of p38 mitogen-activated protein kinase, we show that p38 is required for efficient EGF-induced EGFR destruction but not ..
  94. ncbi p38 mitogen-activated protein kinase regulates osteoblast differentiation through osterix
    Xueying Wang
    The Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Republic of Singapore
    Endocrinology 148:1629-37. 2007
    b>p38 MAPK has been shown to regulate osteoblast differentiation. Inhibition of this kinase with inhibitors or dominant-negative mutant impedes osteoblast differentiation...
  95. pmc Mouse preimplantation embryo responses to culture medium osmolarity include increased expression of CCM2 and p38 MAPK activation
    Barry Fong
    Department of Physiology and Pharmacology, The University of Western Ontario London, Ontario, Canada
    BMC Dev Biol 7:2. 2007
    ..Recently, a novel scaffolding protein called Osmosensing Scaffold for MEKK3 (OSM) was linked to p38 MAPK activation in response to sorbitol-induced hypertonicity...
  96. pmc Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38alpha in abrogating myoblast proliferation
    Eusebio Perdiguero
    Differentiation and Cancer Program, Center for Genomic Regulation CRG PRBB, Barcelona, Spain
    EMBO J 26:1245-56. 2007
    ..However, the relative contribution of the four p38 MAPKs (p38alpha, p38beta, p38gamma and p38delta) to this process is unknown...
  97. pmc Sciatic nerve ligation-induced proliferation of spinal cord astrocytes is mediated by kappa opioid activation of p38 mitogen-activated protein kinase
    Mei Xu
    Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Neurosci 27:2570-81. 2007
    ..by mitogen-activated protein kinase (MAPK) activation by KOR because (1) U50,488 treatment increased phospho-p38 MAPK-immunoreactivity 247 +/- 44% over untreated cells, (2) the increase in phospho-p38 induced by U50,488 was blocked ..
  98. ncbi p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation
    Juan Jose Ventura
    CNIO Spanish National Cancer Center, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Nat Genet 39:750-8. 2007
    Stem cell function is central for the maintenance of normal tissue homeostasis. Here we show that deletion of p38alpha mitogen-activated protein (MAP) kinase in adult mice results in increased proliferation and defective differentiation ..
  99. ncbi p38alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway
    Lijian Hui
    Research Institute of Molecular Pathology, A 1030 Vienna, Austria
    Nat Genet 39:741-9. 2007
    The mitogen-activated protein kinase (MAPK) p38alpha controls inflammatory responses and cell proliferation...
  100. ncbi Sema4C participates in myogenic differentiation in vivo and in vitro through the p38 MAPK pathway
    Haitao Wu
    Department of Brain Protection and Plasticity Research, Beijing Institute of Basic Medical Sciences, Taiping Road 27, Beijing 100850, PR China
    Eur J Cell Biol 86:331-44. 2007
    ..Taken together, these observations reveal novel functional potentialities of Sema4C which suggest that Sema4C promotes terminal myogenic differentiation in a p38 MAPK-dependent manner.
  101. ncbi Antagonistic control of cell fates by JNK and p38-MAPK signaling
    T Wada
    IMBA Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohrgasse 3, Vienna, Austria
    Cell Death Differ 15:89-93. 2008
    ..Two independent stress kinase signaling pathways, p38-MAPK, and JNKs, have evolved that relay developmental and environmental cues to determine cell responses...

Research Grants13

  1. Molecular mechanisms of Glial S100 in Neuroinflammation
    Linda Van Eldik; Fiscal Year: 2004
    ..Aim 1B will determine if p38 and ERK MAP kinases are important for S100B-induced IL-1beta production in activated microglia...
  2. RAS MEDIATED, ANCHORAGE INDEPENDENT GROWTH
    ROBERT KRAUSS; Fiscal Year: 2002
    ..Such genes represent potential mediators of the transformed phenotype. ..
  3. Role of CD164 in Skeletal Myogenesis
    ROBERT KRAUSS; Fiscal Year: 2008
    ..This research should therefore shed light on fundamental processes by which skeletal muscles develop. [unreadable] [unreadable]..
  4. Gene-Environment Interaction in Holoprosencephaly: Role of Fetal Alcohol Exposure
    ROBERT KRAUSS; Fiscal Year: 2008
    ..Such information may have important public health impact and could ultimately aid in the counseling of HPE mutation carriers. [unreadable] [unreadable] [unreadable]..
  5. Mice That Lack CDO: A Model for Mild Holoprosencephaly
    ROBERT KRAUSS; Fiscal Year: 2004
    ....
  6. DIAPHRAGMATIC DYSFUNCTION IN SEPSIS
    GERALD SUPINSKI; Fiscal Year: 2001
    ..These data suggest that the proposed experiments should provide important information regarding the pathogenesis of sepsis-induced muscle dysfunction. ..
  7. FREE RADICALS AND MUSCLE DYSFUNCTION IN HEART FAILURE
    GERALD SUPINSKI; Fiscal Year: 2005
    ..These data suggest that the proposed experiments should provide important information regarding the pathogenesis of heart failure-related skeletal muscle dysfunction. ..
  8. Role of AP-2gamma in Ovarian Germline Stem Cells
    Quinton Winger; Fiscal Year: 2006
    ..The potential for developing successful treatments for human infertility provided by these experiments emphasizes the immediate importance for this research. ..
  9. Cell cycle regulatory proteins in UVB-skin carcinogenes
    Arianna Kim; Fiscal Year: 2007
    ..In addition, our studies could provide a rationale to develop new therapeutic tools targeted towards the protein degradation machinery. ..
  10. HIV ASSOCIATED NEPHROPATHY IN DRUG ADDICTS
    Pravin Singhal; Fiscal Year: 2007
    ..3. Drugs modulation of the renin-angiotensin system contributes to the progression of renal lesions in mice with HIVAN. [unreadable] [unreadable] [unreadable]..
  11. Chk2 as a target for regulating senescence in skin neoplasia
    Arianna Kim; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  12. Caspase Mediated Diaphragmatic Dysfunction
    GERALD SUPINSKI; Fiscal Year: 2009
    ..These experiments will use both transgenic animal models and C2C12 cells to assess the effect of genetic and chemical inhibition of superoxide/nitric oxide on caspase responses. ..
  13. MAPK/PKR Modulation of Diaphragm Weakness
    Gerald S Supinski; Fiscal Year: 2010
    ..These experiments will test our central hypothesis: p38, JNK, and PKR kinase pathways interact to regulate diaphragm muscle death receptor activation, death receptor ..