Genomes and Genes
Gene Symbol: Mapk14
Description: mitogen-activated protein kinase 14
Alias: CSBP2, Crk1, Csbp1, Mxi2, PRKM14, PRKM15, p38, p38-alpha, p38MAPK, p38a, p38alpha, mitogen-activated protein kinase 14, MAP kinase 14, MAP kinase p38 alpha, MAPK 14, cytokine suppressive anti-inflammatory drug binding protein 1, mitogen-activated protein kinase p38 alpha, p38 MAP kinase alpha, p38 MAPK, p38 alpha, tRNA synthetase cofactor p38
Publications196 found, 100 shown here
- Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responsesRam Kumar Mathur
National Centre for Cell Science, Ganeshkhind, Pune 411007, India
Nat Med 10:540-4. 2004..ERK-1/2)-dependent IL-10 expression, whereas stronger signals induce p38 mitogen-activated protein kinase (p38MAPK)-dependent IL-12 production. p38MAPK and ERK-1/2 therefore have counter-regulatory actions...
- The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expressionChun Kim
Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
Nat Immunol 9:1019-27. 2008..Among the many p38 isoforms, p38 alpha is the most widely expressed in adult tissues and can be targeted by various pharmacological inhibitors...
- Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiationAna Cuadrado
Spanish National Cancer Center CNIO, Madrid, Spain
EMBO J 29:2014-25. 2010..We show that the SRCAP subunit named ZNHIT1 or p18(Hamlet), which is a substrate of p38 MAPK, is recruited to the myogenin promoter at the onset of muscle differentiation, in a p38 MAPK-dependent manner...
- Activation of p38 mitogen-activated protein kinase and c-Jun-NH2-terminal kinase by BMP-2 and their implication in the stimulation of osteoblastic cell differentiationJ Guicheux
Division of Bone Diseases, Department of Geriatrics, University Hospital of Geneva, Geneva, Switzerland
J Bone Miner Res 18:2060-8. 2003..We report that BMP-2 can activate JNK and p38 in osteoblastic cells and provide evidences that these MAP kinases have distinct roles in regulating alkaline ..
- Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determinationDebora Bogani
Mammalian Genetics Unit, Medical Research Council MRC Harwell, Oxfordshire, United Kingdom
PLoS Biol 7:e1000196. 2009..Moreover, we describe experiments showing the presence of activated MKK4, a direct target of MAP3K4, and activated p38 in the coelomic region of the XY gonad at 11...
- Cross-talk between the p38alpha and JNK MAPK pathways mediated by MAP kinase phosphatase-1 determines cellular sensitivity to UV radiationChristopher J Staples
CR UK Stress Response Laboratory, Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
J Biol Chem 285:25928-40. 2010..The induction of DUSP1/MKP-1 mRNA and protein in response to UV radiation is mediated by activation of the p38alpha but not the JNK1 or JNK2 MAPK pathways...
- Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibitionJin Mo Park
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0636, USA
Science 297:2048-51. 2002..This dismantling of the p38 MAPK module represents a strategy used by B. anthracis to paralyze host innate immunity.
- Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular developmentR H Adams
European Molecular Biology Laboratory, Heidelberg, Germany
Mol Cell 6:109-16. 2000b>p38alpha MAP kinase is activated in response to many cellular stresses and also regulates the differentiation and/or survival of various cell types in vitro, including skeletal muscle cells and cardiomyocytes...
- p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytesFelix B Engel
Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Genes Dev 19:1175-87. 2005..6%. In contrast, cardiac-specific p38alpha knockout mice show a 92.3% increase in neonatal cardiomyocyte mitoses...
- beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrityXi Zhang
Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Development 136:3357-66. 2009..Thus beta1 integrins can regulate organ branching morphogenesis during development by mediating growth-factor-dependent signaling in addition to their well-defined role as adhesion receptors...
- p38 regulates expression of osteoblast-specific genes by phosphorylation of osterixMaría José Ortuño
Departament de Ciències Fisiològiques II, Universitat de Barcelona, Institut d Investigació Biomèdica de Bellvitge IDIBELL, E 08907 L Hospitalet de Llobregat, Spain
J Biol Chem 285:31985-94. 2010..Furthermore, we show that Osterix is a novel substrate for p38 MAPK in vitro and in vivo and that Ser-73 and Ser-77 are the regulatory sites phosphorylated by p38...
- A male-specific role for p38 mitogen-activated protein kinase in germ cell sex differentiation in miceKatherine Ewen
Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia
Biol Reprod 83:1005-14. 2010..We report that p38 MAPK is phosphorylated and therefore activated only in XY germ cells around the time of sex differentiation...
- Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for activation of p38alpha and p38delta MAPK isoforms by TGF-beta 1 in murine mesangial cellsLin Wang
Renal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Biol Chem 277:47257-62. 2002..TGF-beta1 selectively activated the p38 MAPK isoforms p38alpha and p38delta in wild-type (Mkk3+/+) mesangial cells, but not in MKK3-deficient (Mkk3-/-) mesangial cells...
- A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cellsJ Han
Department of Immunology, Scripps Research Institute, La Jolla, CA 92037
Science 265:808-11. 1994..A protein kinase, p38, that was tyrosine phosphorylated in response to LPS, was cloned...
- The dual-specificity protein phosphatase DUSP9/MKP-4 is essential for placental function but is not required for normal embryonic developmentGraham R Christie
Cancer Research UK Molecular Pharmacology Unit, Biomedical Research Centre, Level 5, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, United Kingdom
Mol Cell Biol 25:8323-33. 2005....
- Murine p38-delta mitogen-activated protein kinase, a developmentally regulated protein kinase that is activated by stress and proinflammatory cytokinesM C Hu
Department of Cell Biology, Amgen, Inc, Thousand Oaks, California 91320, USA
J Biol Chem 274:7095-102. 1999The p38 mitogen-activated protein kinases (MAPK) play a crucial role in stress and inflammatory responses and are also involved in activation of the human immunodeficiency virus gene expression...
- Activation of p38 mitogen-activated protein kinase is required for osteoblast differentiationYuanyu Hu
Institute of Molecular and Cell Biology, National University of Singapore, Singapore 117609
Endocrinology 144:2068-74. 2003b>p38 MAPK is a conserved subfamily of MAPKs involved in inflammatory response, stress response, cell growth and survival, as well as differentiation of a variety of cell types...
- Roles of JNK-1 and p38 in selective induction of apoptosis by capsaicin in ras-transformed human breast epithelial cellsHye Jung Kang
College of Pharmacy, Duksung Women s University, 4129 Ssangmun dong, Tobong ku, Seoul 132 714, Korea
Int J Cancer 103:475-82. 2003..In H-ras MCF10A cells, capsaicin treatment markedly activated c-Jun N-terminal protein kinase (JNK)-1 and p38 matigen-activated protein kinase (MAPK) while it deactivated extracellular signal-regulated protein kinases (ERKs)...
- Interleukin-3 stimulation of mcl-1 gene transcription involves activation of the PU.1 transcription factor through a p38 mitogen-activated protein kinase-dependent pathwayJu Ming Wang
Institute of Molecular Biology, Academia Sinica, 128 Yen Jiou Yuan Road, Section 2, Nankang, Taipei 11529, Taiwan, Republic of China
Mol Cell Biol 23:1896-909. 2003..The latter effect coincides with the increased phosphorylation of PU.1 following IL-3 activation of a p38 mitogen-activated protein kinase (p38(MAPK))-dependent pathway...
- p38 alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failureJan Heinrichsdorff
Institute for Genetics, Centre for Molecular Medicine CMMC, and Cologne Excellence Cluster on Cellular Stress Responses in Aging associated Diseases CECAD, University of Cologne, Zülpicher Str 47, D 50674 Cologne, Germany
EMBO Rep 9:1048-54. 2008..Here, we show that hepatocyte-specific ablation of p38alpha in mice results in excessive activation of JNK in the liver after in vivo challenge with bacterial ..
- Inhibition and genetic deficiency of p38 MAPK up-regulates heme oxygenase-1 gene expression via Nrf2Srivatsava Naidu
Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University Giessen, Giessen, Germany
J Immunol 182:7048-57. 2009..basal HO-1 gene expression levels were markedly higher in untreated murine embryonic fibroblasts (MEF) from p38alpha(-/-) mice compared with those from wild-type mice...
- Inhibitor of NF-kappa B kinases alpha and beta are both essential for high mobility group box 1-mediated chemotaxis [corrected]Marianna Penzo
Vita Salute San Raffaele University, School of Medicine, San Raffaele Scientific Institute, Milano, Italy
J Immunol 184:4497-509. 2010..Thus, proinflammatory HMGB1 chemotactic responses mechanistically require the differential collaboration of both IKK-dependent NF-kappaB signaling pathways...
- Myocardial adenosine A(1)-receptor-mediated adenoprotection involves phospholipase C, PKC-epsilon, and p38 MAPK, but not HSP27Richard A Fenton
Dept of Physiology, Univ of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
Am J Physiol Heart Circ Physiol 298:H1671-8. 2010..In a second study, p38 MAPK and heat shock protein 27 (HSP27), found by others to be associated with the loss of myocardial contractile ..
- Leptin regulates MMP-2, TIMP-1 and collagen synthesis via p38 MAPK in HL-1 murine cardiomyocytesKristin Schram
Department of Biology, York University, Toronto, Canada
Cell Mol Biol Lett 15:551-63. 2010..Leptin is known to stimulate phosphorylation of p38 MAPK in cardiac cells and utilization of the p38 MAPK inhibitor, SB203580, demonstrated that this kinase also plays a ..
- Macrophage-derived BAFF induces AID expression through the p38MAPK/CREB and JNK/AP-1 pathwaysHyun A Kim
Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 200 701, Republic of Korea
J Leukoc Biol 89:393-8. 2011..Subsequent analysis of BAFF signaling suggested that BAFF induces AID through BCMA, a BAFF-receptor, and p38MAPK and CREB act as intermediates in AID expression. In addition, JNK and AP-1 have similar activities...
- Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesisJ S Mudgett
Merck Research Laboratories, Rahway, NJ 07065, USA
Proc Natl Acad Sci U S A 97:10454-9. 2000..mediates signaling in response to environmental stresses and inflammatory cytokines, but the requirements for the p38 MAPK pathway in normal mammalian development have not been elucidated...
- ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunityAtsushi Matsuzawa
Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
Nat Immunol 6:587-92. 2005..kinase 1 (ASK1) is an evolutionarily conserved mitogen-activated protein 3-kinase that activates both Jnk and p38 mitogen-activated protein kinases...
- Heme oxygenase-1-derived carbon monoxide requires the activation of transcription factor NF-kappa B to protect endothelial cells from tumor necrosis factor-alpha-mediated apoptosisSophie Brouard
Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 277:17950-61. 2002..This effect relies on the activation of p38 MAPK. We now demonstrate that HO-1/CO requires the activation of the transcription factor NF-kappaB to exert this anti-..
- Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activationHayato Nakagawa
Department of Gastroenterology, University of Tokyo, Hongo, Bunkyo ku, Tokyo
Gastroenterology 135:1311-21. 2008..We tested the hypothesis that ASK1 was involved in APAP-induced JNK activation and liver injury...
- Inhibition of p38 MAP kinase- and RICK/NF-kappaB-signaling suppresses inflammatory bowel diseaseEike Hollenbach
Institute of Experimental Internal Medicine, Otto von Guericke University, Magdeburg, Germany
FASEB J 18:1550-2. 2004..The goal of this study was to evaluate the effects of the p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580 on inflammatory responses using the DSS-induced ..
- Mechanical stress activates xanthine oxidoreductase through MAP kinase-dependent pathwaysRaja Elie E Abdulnour
Division of Pulmonary and Critical Care Medicine, Bloomberg School of Public Health, Baltimore, Maryland, USA
Am J Physiol Lung Cell Mol Physiol 291:L345-53. 2006..There was evidence of p38 MAP kinase, ERK1/2, and ERK5 phosphorylation, but no change in JNK phosphorylation...
- A Cdo-Bnip-2-Cdc42 signaling pathway regulates p38alpha/beta MAPK activity and myogenic differentiationJong Sun Kang
Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
J Cell Biol 182:497-507. 2008The p38alpha/beta mitogen-activated protein kinase (MAPK) pathway promotes skeletal myogenesis, but the mechanisms by which it is activated during this process are unclear...
- Increased endothelial mitogen-activated protein kinase phosphatase-1 expression suppresses proinflammatory activation at sites that are resistant to atherosclerosisMustafa Zakkar
British Heart Foundation Cardiovascular Sciences Unit, National Heart and Lung Institute, Imperial College London, London, United Kingdom
Circ Res 103:726-32. 2008..induce adhesion molecules (eg, vascular cell adhesion molecule [VCAM]-1) in endothelial cells (ECs) by activating p38 and c-Jun N-terminal kinase (JNK) mitogen-activated protein (MAP) kinases by phosphorylation...
- Distinct effects of p38alpha deletion in myeloid lineage and gut epithelia in mouse models of inflammatory bowel diseaseMotoyuki Otsuka
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92307, USA
Gastroenterology 138:1255-65, 1265.e1-9. 2010b>p38Alpha is a mitogen-activated protein kinase that mediates inflammatory responses, but its role in inflammatory bowel disease is unclear...
- p38MAPK controls expression of multiple cell cycle inhibitors and islet proliferation with advancing ageEsther Sook Miin Wong
Institute of Molecular and Cell Biology, Proteos, Singapore
Dev Cell 17:142-9. 2009..Little is known, however, about the upstream signals that induce their expression. Here, we explore the role of p38MAPK by generating a dominant-negative allele (p38(AF)) in which activating phosphorylation sites Thr180 and Tyr182 ..
- A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphataseC Blanco-Aparicio
Instituto de Investigaciones Citologicas, 46010 Valencia, Spain
J Cell Biol 147:1129-36. 1999..binding and tyrosine dephosphorylation of the MAP kinases extracellular signal-regulated kinase (ERK)1/2 and p38alpha were impaired...
- Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligationKoichi Obata
Department of Anatomy and Neuroscience, Hyogo College of Medicine, Hyogo 663 8501, Japan
J Neurosci 24:10211-22. 2004..partial nerve injury, we examined the phosphorylation of extracellular signal-regulated protein kinase (ERK), p38 MAPK, and c-Jun N-terminal kinase (JNK) in the L4 and L5 dorsal root ganglion (DRG) in the L5 spinal nerve ligation (..
- E47 phosphorylation by p38 MAPK promotes MyoD/E47 association and muscle-specific gene transcriptionFrederic Lluis
Center for Genomic Regulation, Program on Differentiation and Cancer, Barcelona, Spain
EMBO J 24:974-84. 2005..Here we show that p38 MAPK, whose activity is essential for myogenesis, regulates MyoD/E47 heterodimerization...
- Requirement of the MAP kinase signaling pathways for mouse preimplantation developmentMomoko Maekawa
Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
Development 132:1773-83. 2005..Our results show that inhibition of the JNK pathway or of the p38 MAP kinase pathway, but not of the ERK pathway, results in inhibition of cavity formation, and that JNK and p38 are ..
- Genetic deficiency of p38alpha reveals its critical role in myoblast cell cycle exit: the p38alpha-JNK connectionEusebio Perdiguero
Program on Differentiation and Cancer, Centre for Genomic Regulation, UPF PRBB, CIBER de Enfermedades Neurodegenerativas, Barcelona, Spain
Cell Cycle 6:1298-303. 2007..However, the relative contribution of the four p38 MAP kinases (p38alpha, p38beta, p38gamma and p38delta) to this process was unknown...
- Macrophage deficiency of p38alpha MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in miceTracie A Seimon
Department of Medicine, Division of Molecular Medicine, Columbia University, PH 9 405, 630 W 168th Street, New York, New York 10032, USA
J Clin Invest 119:886-98. 2009..Here we placed Apoe-/- mice deficient in macrophage p38alpha MAPK on a Western diet and found that they had a marked increase in macrophage apoptosis and plaque necrosis...
- Characterization of a murine gene encoding a developmentally regulated cytoplasmic dual-specificity mitogen-activated protein kinase phosphataseRobin J Dickinson
Cancer Research UK, Molecular Pharmacology Unit, Biomedical Research Centre, Ninewells Hospital, Dundee DD1 9SY, Scotland, U K
Biochem J 364:145-55. 2002..extracellular signal-regulated kinases (ERKs) 1 and 2 and, to a lesser extent, the stress-activated MAPK p38alpha. These properties define the ability of this enzyme to dephosphorylate and inactivate ERK1/2 and p38alpha, but ..
- Negative feedback regulation of MKK6 mRNA stability by p38alpha mitogen-activated protein kinaseConcetta Ambrosino
European Molecular Biology Laboratory, 69117 Heidelberg, Germany
Mol Cell Biol 23:370-81. 2003..The most abundant and broadly expressed p38 MAP kinase is p38alpha, which can also control the proliferation, differentiation, and survival of several cell types...
- Catalytic activation of mitogen-activated protein (MAP) kinase phosphatase-1 by binding to p38 MAP kinase: critical role of the p38 C-terminal domain in its negative regulationD Hutter
Stress Signaling Unit, Laboratory of Cellular and Molecular Biology, National Institute on Aging, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Biochem J 352:155-63. 2000..Here we have shown that MKP-1 associates directly with p38 MAP kinase both in vivo and in vitro, and that this interaction enhances the catalytic activity of MKP-1...
- Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1Eva Pålsson McDermott
Department of Biochemistry and Biotechnology Institute, Trinity College, Dublin 2, Ireland
J Biol Chem 277:7808-15. 2002..Here we have further investigated the role of Ras and Rap in p38 MAPK activation by IL-1...
- Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1)Kerstin Piechotta
Department of Anesthesiology and Center for Molecular Neuroscience, Vanderbilt University, Medical Center, Nashville, Tennessee 37232, USA
J Biol Chem 277:50812-9. 2002..We conclude that several cation chloride co-transporters interact with SPAK and/or OSR1, and we hypothesize that this interaction might play a role during the initiation of the cellular stress response...
- p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 geneWenhong Cao
Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
Mol Cell Biol 24:3057-67. 2004..receptor gamma (PPARgamma) coativator 1alpha (PGC-1alpha), members of two distinct nuclear factor families, p38 MAPK controls the expression of the UCP1 gene through their respective interactions with a cAMP response element and a ..
- Role of NF-kappaB and p38 MAP kinase signaling pathways in the lipopolysaccharide-dependent activation of heme oxygenase-1 gene expressionNastiti Wijayanti
Institut fur Klinische Chemie und Pathobiochemie, Justus Liebig Universitat Giessen, D 35392 Giessen, Germany
Antioxid Redox Signal 6:802-10. 2004..The results suggest that the NF-kappaB and p38 MAPK signaling pathways mediate the LPS-dependent induction of HO-1 gene expression via DNA sequences of the proximal ..
- The role of mitogen-activated protein kinase phosphatase-1 in the response of alveolar macrophages to lipopolysaccharide: attenuation of proinflammatory cytokine biosynthesis via feedback control of p38Qun Zhao
Center for Developmental Pharmacology and Toxicology, Children s Research Institute, Children s Hospital, Department of Pediatrics, The Ohio State University, Columbus, Ohio 43205, USA
J Biol Chem 280:8101-8. 2005..We found that LPS triggered transient activation of three MAP kinase subfamilies, ERK, JNK, and p38, in both immortalized and primary murine alveolar macrophages...
- p38 mitogen-activated protein kinase (MAPK) first regulates filamentous actin at the 8-16-cell stage during preimplantation developmentAndrew J M Paliga
Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada N6A 5C1
Biol Cell 97:629-40. 2005..protein kinases (JNK/SAPK); the ERKs (extracellular-signal-regulated kinases); the ERK5 or big MAPK1; and the p38 MAPK group of protein kinases, all of which are highly conserved...
- Caveolin-1 confers antiinflammatory effects in murine macrophages via the MKK3/p38 MAPK pathwayXiao Mei Wang
Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, 3459 Fifth Avenue, MUH 628, Pittsburgh, PA 15213, USA
Am J Respir Cell Mol Biol 34:434-42. 2006..Taken together, our data suggest that caveolin-1 acts as a potent immunomodulatory effector molecule in immune cells and that the regulation of LPS-induced cytokine production by caveolin-1 involves the MKK3/p38 MAPK pathway.
- p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcriptsPaola Briata
Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
Mol Cell 20:891-903. 2005..Here, we demonstrate that p38 alpha and beta isoforms also control muscle-gene expression posttranscriptionally, by stabilizing critical myogenic ..
- c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activityEwa Stepniak
Research Institute of Molecular Pathology IMP, A 1030 Vienna, Austria
Genes Dev 20:2306-14. 2006..Importantly, conditional deletion of p38alpha in livers of c-jun (Deltali*) mice fully restored hepatocyte proliferation and attenuated increased p21 protein ..
- Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancerBabak Oskouian
Children s Hospital Oakland Research Institute Center for Cancer Research, Oakland, CA 94609 1673, USA
Proc Natl Acad Sci U S A 103:17384-9. 2006..This effect seemed to be independent of ceramide generation but required SPL enzymatic activity and the actions of p38 MAP kinase, p53, p53-inducible death domain protein (PIDD), and caspase-2 as shown by molecular and chemical ..
- Convergence of Igf2 expression and adhesion signalling via RhoA and p38 MAPK enhances myogenic differentiationFiona A Lovett
The Babraham Institute, Babraham Research Campus, Cambridge, CB2 4AT, UK
J Cell Sci 119:4828-40. 2006..PI3-K and p38 MAPK are both essential for successful myogenesis...
- Cytokine-like 1 (Cytl1) regulates the chondrogenesis of mesenchymal cellsJae Sung Kim
Department of Life Sciences, Research Center for Biomolecular Nanotechnology, Gwangju Institute of Science and Technology, Gwangju 500 712, Korea
J Biol Chem 282:29359-67. 2007..Thus, our results collectively suggest that chondrocyte-specific Cytl1 regulates chondrogenesis as a novel autocrine factor, but not hypertrophic maturation of chondrocytes during cartilage development...
- Transforming growth factor-beta-activated protein kinase 1-binding protein (TAB)-1alpha, but not TAB1beta, mediates cytokine-induced p38 mitogen-activated protein kinase phosphorylation and cell death in insulin-producing cellsNatalia Makeeva
Department of Medical Cell Biology, Uppsala University, S 75123 Uppsala, Sweden
Endocrinology 149:302-9. 2008Previous studies have indicated that the p38 MAPK participates in signaling events that lead to the death of the insulin-producing beta-cell...
- Phosphorylation of fibroblast growth factor (FGF) receptor 1 at Ser777 by p38 mitogen-activated protein kinase regulates translocation of exogenous FGF1 to the cytosol and nucleusVigdis Sørensen
Centre for Cancer Biomedicine, Faculty Division Norwegian Radium Hospital, University of Oslo, Oslo, Norway
Mol Cell Biol 28:4129-41. 2008..translocation was inhibited after chemical inhibition of p38 MAPK or after small interfering RNA knockdown of p38alpha. Translocation was increased after stimulation of p38 MAPK with anisomycin, mannitol, or H2O2...
- Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesisToshiharu Sakurai
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Cancer Cell 14:156-65. 2008..We examined whether hepatocyte p38 alpha, found to inhibit liver carcinogenesis, acts similarly to IKK beta in control of ROS metabolism and cell death...
- Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcusSybille Kenzel
Center for Pediatric and Adolescent Medicine, University Medical Center Freiburg, Freiburg, Germany
Infect Immun 77:2474-81. 2009..GBS-induced, MyD88-dependent phosphorylation of the mitogen-activated protein kinase p38 activated the transcription factor AP-1 and early growth response factor 1 (Egr-1) but not NF-kappaB...
- Target gene specificity of USF-1 is directed via p38-mediated phosphorylation-dependent acetylationSébastien Corre
Signaling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted RH8 OTL, United Kingdom
J Biol Chem 284:18851-62. 2009..Following UV irradiation, USF-1 is phosphorylated by the p38 stress-activated kinase on threonine 153 and directly up-regulates expression of the POMC, MC1R, TYR, TYRP-1 and ..
- A chemical genetic approach reveals that p38alpha MAPK activation by diphosphorylation aggravates myocardial infarction and is prevented by the direct binding of SB203580Sarawut Kumphune
King s College London British Heart Foundation Centre, Cardiovascular Division, The Rayne Institute and StThomas Hospital, London SE1 7EH, United Kingdom
J Biol Chem 285:2968-75. 2010..We addressed these controversies by using mice in which the p38alpha alleles were targeted to cause substitution of the gatekeeper residue and resistance to inhibition...
- The structure of mitogen-activated protein kinase p38 at 2.1-A resolutionZ Wang
Department of Biochemistry and Biophysics, University of Texas Southwestern Medical Center at Dallas, 75235, USA
Proc Natl Acad Sci U S A 94:2327-32. 1997The structure of mitogen-activated protein (MAP) kinase p38 has been solved at 2.1-A to an R factor of 21.0%, making p38 the second low activity MAP kinase solved to date...
- Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytesT Sugawara
Department of Immunology, Institute of Basic Medical Sciences, University of Tsukuba, Japan
Immunity 9:565-74. 1998..We also show that the MKK6-p38 signaling pathway is critically involved in inducing negative selection of thymocytes...
- Deficiency of the stress kinase p38alpha results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cellsM Allen
Department of Respiratory, Allergy, Immunology, Inflammation, and Infectious Diseases, Central Research, Pfizer, Inc, Groton, CT 06340, USA
J Exp Med 191:859-70. 2000..A genetic approach was employed to inactivate the gene encoding one p38 isoform, p38alpha. Mice null for the p38alpha allele die during embryonic development...
- Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathwayC Tournier
Howard Hughes Medical Institute, Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Science 288:870-4. 2000..These data indicate that mitochondria are influenced by proapoptotic signal transduction through the JNK pathway...
- p38 Mitogen-activated protein kinase-, calcium-calmodulin-dependent protein kinase-, and calcineurin-mediated signaling pathways transcriptionally regulate myogenin expressionQing Xu
Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, People s Republic of China
Mol Biol Cell 13:1940-52. 2002..as an important transcriptional target under the control of three intracellular signaling pathways, namely, the p38 mitogen-activated protein kinase- (MAPK), calcium-calmodulin-dependent protein kinase- (CaMK), and calcineurin-..
- Innate recognition of bacteria by a macrophage cytosolic surveillance pathwayMARY O'RIORDAN
Department of Molecular and Cell Biology, School of Public Health, University of California, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 99:13861-6. 2002..signaling is associated with translocation of NF-kappaB into the nucleus and phosphorylation of the p38 mitogen-activated protein (MAP) kinase...
- Selective suppression of neutrophil accumulation in ongoing pulmonary inflammation by systemic inhibition of p38 mitogen-activated protein kinaseJerry A Nick
Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Immunol 169:5260-9. 2002..Inhibition of p38 MAPK before exposing a cell to stress stimuli has profound anti-inflammatory effects, but little is known about the ..
- JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factorsClement M Lee
Fels Institute for Cancer Research and Molecular Biology, School of Medicine, Temple University, Philadelphia, PA 19140, USA
Proc Natl Acad Sci U S A 99:14189-94. 2002..acts as a scaffolding protein to bring together Max and c-Myc along with JNK (c-Jun NH2-terminal kinase) and p38MAPK, as well as their upstream kinases MKK4 (MAPK kinase 4) and MEKK3 (MAPK kinase kinase 3)...
- The effect of aging on p38 signaling pathway activity in the mouse liver and in response to ROS generated by 3-nitropropionic acidChing Chyuan Hsieh
Department of Human Biological Chemistry and Genetics, The University of Texas Medical Branch, 613 Basic Sci Bldg, Rt 0643, Galveston, TX 77555 0643, USA
Mech Ageing Dev 123:1423-35. 2002..aging affects the response of the p38 alpha signaling pathway to 3-NPA...
- Disruption of a single copy of the p38alpha MAP kinase gene leads to cardioprotection against ischemia-reperfusionKinya Otsu
Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
Biochem Biophys Res Commun 302:56-60. 2003..We examined the role of p38alpha in ischemia-reperfusion injury by studying p38alpha(+/-) mice...
- Feedback control of the protein kinase TAK1 by SAPK2a/p38alphaPeter C F Cheung
MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, Dow Street, University of Dundee, Dundee DD1 5EH, UK
EMBO J 22:5793-805. 2003TAB1, a subunit of the kinase TAK1, was phosphorylated by SAPK2a/p38alpha at Ser423, Thr431 and Ser438 in vitro...
- Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivoRobert A Kaiser
Department of Pediatrics, University of Cincinnati, Children s Hospital Medical Center, Division of Molecular Cardiovascular Biology, Cincinnati, Ohio 45229 3039, USA
J Biol Chem 279:15524-30. 2004..p38 vectors reduced apoptosis induced by 2-deoxyglucose treatment, whereas overexpression of wild-type p38alpha or an activated mitogen-activated protein kinase kinase (MKK)6 mutant each enhanced cell death...
- Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathwayDmitry V Bulavin
Gene Response Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Genet 36:343-50. 2004..encoding Wip1 phosphatase activated the p53 and p16 (also called Ink4a)-p19 (also called ARF) pathways through p38 MAPK signaling and suppressed in vitro transformation of mouse embryo fibroblasts (MEFs) by oncogenes...
- Streptococcus pneumoniae-induced p38 MAPK-dependent phosphorylation of RelA at the interleukin-8 promotorBernd Schmeck
Department of Internal Medicine Infectious Diseases, Charite, University Medicine Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
J Biol Chem 279:53241-7. 2004..The present study shows that NF-kappaB and p38 MAPK signaling pathways contribute to chemokine synthesis by lung epithelial cells in response to pneumococci...
- p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overloadKazuhiko Nishida
Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
Mol Cell Biol 24:10611-20. 2004..The mitogen-activated protein kinase p38alpha is a key component of stress response pathways in various types of cells...
- Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV lightTamara Tanos
Laboratorio de Fisiologia y Biologia Molecular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IFIBYNE CONICET, 1428 Buenos Aires, Argentina
J Biol Chem 280:18842-52. 2005..Using a specific pharmacological inhibitor for p38alpha and -beta, we found that most likely these two isoforms mediate UV-induced c-Fos phosphorylation in vivo...
- Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinasesJesus M Salvador
Gene Response Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Immunol 6:390-5. 2005..Here we show that T cells stimulated through the T cell receptor (TCR) used an alternative mechanism in which p38 was phosphorylated on Tyr323 and subsequently autophosphorylated residues Thr180 and Tyr182...
- Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathwayTakayuki Akimoto
Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 280:19587-93. 2005..transient increase of Pgc-1alpha mRNA expression in mouse plantaris muscle, concurrent with an activation of the p38 MAPK pathway...
- Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathwaysNyaya Kelkar
Howard Hughes Medical Institute, Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation St, Worcester, MA 01605, USA
Mol Cell Biol 25:2733-43. 2005..Specifically, JIP4 does not activate JNK signaling. In contrast, JIP4 serves as an activator of the p38 mitogen-activated protein (MAP) kinase pathway by a mechanism that requires the MAP kinase kinases MKK3 and MKK6...
- The p38alpha/beta MAPK functions as a molecular switch to activate the quiescent satellite cellNathan C Jones
Bayer Corporation, Research Triangle Park, NC 27709, USA
J Cell Biol 169:105-16. 2005..Here, we report that the p38alpha/beta family of mitogen-activated protein kinases (MAPKs) reversibly regulates the quiescent state of the skeletal ..
- A novel isoform of Vinexin, Vinexin gamma, regulates Sox9 gene expression through activation of MAPK cascade in mouse fetal gonadMakoto Matsuyama
Division of Sex Differentiation, National Institute for Basic Biology, Okazaki 444 8787, Japan
Genes Cells 10:421-34. 2005..Thus, Vinexin gamma seems to be implicated in regulation of Sox9 gene expression by modulating MAPK cascade in mouse fetal gonads...
- Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genesAxel Thiefes
Institute of Pharmacology, Medical School Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
J Biol Chem 280:27728-41. 2005..Expression of this protein inhibited tumor necrosis factor (TNF)-induced activation of NFkappaB, JNK, and p38 MAPK and sensitized the cells to TNF-induced apoptosis...
- Regulation of vertebrate myotome development by the p38 MAP kinase-MEF2 signaling pathwayLuciana De Angelis
Istituto di Istologia ed Embriologia Generale, Universita di Roma La Sapienza, Via A Scarpa 14, 00161 Rome, Italy
Dev Biol 283:171-9. 2005..Here, we report a critical interaction between the p38 mitogen-activated protein kinase (p38 MAPK) and MEF2 in the developing somite myotome...
- Role of p38 MAPK in UVB-induced inflammatory responses in the skin of SKH-1 hairless miceArianna L Kim
Department of Dermatology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Invest Dermatol 124:1318-25. 2005..We assessed the effects of ultraviolet B (UVB) on the p38 MAPK pathway and determined whether cyclooxygenase (COX)-2 expression is downstream of this kinase in the skin of UVB-..
- Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulatorsJin Mo Park
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA
Immunity 23:319-29. 2005..with the TLR4-activating bacterium Bacillus anthracis triggers an apoptotic response due to inhibition of p38 MAP kinase activation by the bacterial-produced lethal toxin...
- Constitutive activation of MKK6 in chondrocytes of transgenic mice inhibits proliferation and delays endochondral bone formationRen Zhang
Department of Molecular Genetics, Graduate Program in Genes and Development, University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 103:365-70. 2006..Therefore, our study provides in vivo evidence for the role of p38 in endochondral ossification and suggests that Sox9 is a likely downstream target of the p38 MAPK pathway.
- p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulationIrene E Zohn
Howard Hughes Medical Institute, Department of Pediatrics, Section of Developmental Biology, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
Cell 125:957-69. 2006..We demonstrate that p38 MAP kinase and a p38-interacting protein (p38IP) are critically required for downregulation of E-cadherin during ..
- Negative regulation of Akt activity by p38alpha MAP kinase in cardiomyocytes involves membrane localization of PP2A through interaction with caveolin-1Susana Zuluaga
Departamento de Bioquimica y Biologia Molecular II, Facultad de Farmacia, UCM, Ciudad Universitaria, 28040 Madrid, Spain
Cell Signal 19:62-74. 2007Cardiomyocyte-derived cell lines deficient in p38alpha are more resistant to apoptosis owing to lower expression of the pro-apoptotic proteins Bax and Fas and upregulation of the ERK survival pathway...
- Feedback control of MKP-1 expression by p38Jun Hao Hu
Signal Transduction Lab of Institute of Health Sciences, Shanghai Institutes for Biological Sciences corrected Chinese Academy of Sciences and corrected Shanghai Jiao Tong University School of Medicine, China
Cell Signal 19:393-400. 2007..Thus, p38 MAPK plays a critical role in mediating expression of MKP-1 at a post-transcriptional level...
- Activation of the Mitf promoter by lipid-stimulated activation of p38-stress signalling to CREBBidisha Saha
Department of Cellular Biochemistry, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Jadavpur, Kolkata 700 032, India
Pigment Cell Res 19:595-605. 2006..Here we show that the Mitf promoter is induced by lipid signalling via the p38 stress-activated kinase pathway that is also activated by a wide range of receptors as well as UV irradiation...
- p38 kinase regulates epidermal growth factor receptor downregulation and cellular migrationMark R Frey
Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Vanderbilt University School of Medicine, 2215 Garland Avenue, Nashville, TN 37232, USA
EMBO J 25:5683-92. 2006..Using pharmacological and RNA interference inhibition of p38 mitogen-activated protein kinase, we show that p38 is required for efficient EGF-induced EGFR destruction but not ..
- p38 mitogen-activated protein kinase regulates osteoblast differentiation through osterixXueying Wang
The Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673, Republic of Singapore
Endocrinology 148:1629-37. 2007b>p38 MAPK has been shown to regulate osteoblast differentiation. Inhibition of this kinase with inhibitors or dominant-negative mutant impedes osteoblast differentiation...
- Mouse preimplantation embryo responses to culture medium osmolarity include increased expression of CCM2 and p38 MAPK activationBarry Fong
Department of Physiology and Pharmacology, The University of Western Ontario London, Ontario, Canada
BMC Dev Biol 7:2. 2007..Recently, a novel scaffolding protein called Osmosensing Scaffold for MEKK3 (OSM) was linked to p38 MAPK activation in response to sorbitol-induced hypertonicity...
- Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38alpha in abrogating myoblast proliferationEusebio Perdiguero
Differentiation and Cancer Program, Center for Genomic Regulation CRG PRBB, Barcelona, Spain
EMBO J 26:1245-56. 2007..However, the relative contribution of the four p38 MAPKs (p38alpha, p38beta, p38gamma and p38delta) to this process is unknown...
- Sciatic nerve ligation-induced proliferation of spinal cord astrocytes is mediated by kappa opioid activation of p38 mitogen-activated protein kinaseMei Xu
Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington 98195, USA
J Neurosci 27:2570-81. 2007..by mitogen-activated protein kinase (MAPK) activation by KOR because (1) U50,488 treatment increased phospho-p38 MAPK-immunoreactivity 247 +/- 44% over untreated cells, (2) the increase in phospho-p38 induced by U50,488 was blocked ..
- p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiationJuan Jose Ventura
CNIO Spanish National Cancer Center, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
Nat Genet 39:750-8. 2007Stem cell function is central for the maintenance of normal tissue homeostasis. Here we show that deletion of p38alpha mitogen-activated protein (MAP) kinase in adult mice results in increased proliferation and defective differentiation ..
- p38alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathwayLijian Hui
Research Institute of Molecular Pathology, A 1030 Vienna, Austria
Nat Genet 39:741-9. 2007The mitogen-activated protein kinase (MAPK) p38alpha controls inflammatory responses and cell proliferation...
- Sema4C participates in myogenic differentiation in vivo and in vitro through the p38 MAPK pathwayHaitao Wu
Department of Brain Protection and Plasticity Research, Beijing Institute of Basic Medical Sciences, Taiping Road 27, Beijing 100850, PR China
Eur J Cell Biol 86:331-44. 2007..Taken together, these observations reveal novel functional potentialities of Sema4C which suggest that Sema4C promotes terminal myogenic differentiation in a p38 MAPK-dependent manner.
- Antagonistic control of cell fates by JNK and p38-MAPK signalingT Wada
IMBA Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohrgasse 3, Vienna, Austria
Cell Death Differ 15:89-93. 2008..Two independent stress kinase signaling pathways, p38-MAPK, and JNKs, have evolved that relay developmental and environmental cues to determine cell responses...
- Molecular mechanisms of Glial S100 in NeuroinflammationLinda Van Eldik; Fiscal Year: 2004..Aim 1B will determine if p38 and ERK MAP kinases are important for S100B-induced IL-1beta production in activated microglia...
- RAS MEDIATED, ANCHORAGE INDEPENDENT GROWTHROBERT KRAUSS; Fiscal Year: 2002..Such genes represent potential mediators of the transformed phenotype. ..
- Role of CD164 in Skeletal MyogenesisROBERT KRAUSS; Fiscal Year: 2008..This research should therefore shed light on fundamental processes by which skeletal muscles develop. [unreadable] [unreadable]..
- Gene-Environment Interaction in Holoprosencephaly: Role of Fetal Alcohol ExposureROBERT KRAUSS; Fiscal Year: 2008..Such information may have important public health impact and could ultimately aid in the counseling of HPE mutation carriers. [unreadable] [unreadable] [unreadable]..
- Mice That Lack CDO: A Model for Mild HoloprosencephalyROBERT KRAUSS; Fiscal Year: 2004....
- DIAPHRAGMATIC DYSFUNCTION IN SEPSISGERALD SUPINSKI; Fiscal Year: 2001..These data suggest that the proposed experiments should provide important information regarding the pathogenesis of sepsis-induced muscle dysfunction. ..
- FREE RADICALS AND MUSCLE DYSFUNCTION IN HEART FAILUREGERALD SUPINSKI; Fiscal Year: 2005..These data suggest that the proposed experiments should provide important information regarding the pathogenesis of heart failure-related skeletal muscle dysfunction. ..
- Role of AP-2gamma in Ovarian Germline Stem CellsQuinton Winger; Fiscal Year: 2006..The potential for developing successful treatments for human infertility provided by these experiments emphasizes the immediate importance for this research. ..
- Cell cycle regulatory proteins in UVB-skin carcinogenesArianna Kim; Fiscal Year: 2007..In addition, our studies could provide a rationale to develop new therapeutic tools targeted towards the protein degradation machinery. ..
- HIV ASSOCIATED NEPHROPATHY IN DRUG ADDICTSPravin Singhal; Fiscal Year: 2007..3. Drugs modulation of the renin-angiotensin system contributes to the progression of renal lesions in mice with HIVAN. [unreadable] [unreadable] [unreadable]..
- Chk2 as a target for regulating senescence in skin neoplasiaArianna Kim; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Caspase Mediated Diaphragmatic DysfunctionGERALD SUPINSKI; Fiscal Year: 2009..These experiments will use both transgenic animal models and C2C12 cells to assess the effect of genetic and chemical inhibition of superoxide/nitric oxide on caspase responses. ..
- MAPK/PKR Modulation of Diaphragm WeaknessGerald S Supinski; Fiscal Year: 2010..These experiments will test our central hypothesis: p38, JNK, and PKR kinase pathways interact to regulate diaphragm muscle death receptor activation, death receptor ..