Map3k7

Summary

Gene Symbol: Map3k7
Description: mitogen-activated protein kinase kinase kinase 7
Alias: B430101B05, C87327, Tak1, mitogen-activated protein kinase kinase kinase 7, TGF-beta-activated kinase 1, transforming growth factor-beta-activated kinase 1
Species: mouse

Top Publications

  1. doi TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer
    Kira Bettermann
    Department of Internal Medicine III, University Hospital RWTH Aachen, D 52074 Aachen, Germany
    Cancer Cell 17:481-96. 2010
  2. pmc A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation
    James Schuman
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee 53226, USA
    Blood 113:4566-74. 2009
  3. doi TNF-α/Fas-RIP-1-induced cell death signaling separates murine hematopoietic stem cells/progenitors into 2 distinct populations
    Yechen Xiao
    Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL 60153, USA
    Blood 118:6057-67. 2011
  4. pmc Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions
    Francesco J Conti
    The Scripps Research Institute, Department of Cell Biology and Institute of Childhood and Neglected Diseases, La Jolla, CA 92037, USA
    Development 136:3597-606. 2009
  5. pmc Essential role of TAK1 in thymocyte development and activation
    Hong Hsing Liu
    Department of Molecular Biology and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 103:11677-82. 2006
  6. ncbi Disabled-2 (Dab2) mediates transforming growth factor beta (TGFbeta)-stimulated fibronectin synthesis through TGFbeta-activated kinase 1 and activation of the JNK pathway
    Barbara A Hocevar
    Department of Cell Biology, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 280:25920-7. 2005
  7. pmc Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1
    Sandra Blanco
    Programa de Oncología Translacional, Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca E 37007, Spain
    Mol Cell Biol 27:7273-83. 2007
  8. ncbi Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis
    Yoshihiro Komatsu
    Center for Animal Resources and Development, Graduate School of Molecular and Genomic Pharmacy, Kumamoto University, Honjo 2 2 1, Kumamoto 860 0811, Japan
    Mech Dev 119:239-49. 2002
  9. ncbi Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation
    Marcello Arsura
    Department of Pharmacology, University of Tennessee College of Medicine, Memphis 38163, USA
    Oncogene 22:412-25. 2003
  10. pmc Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha
    Peter C F Cheung
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, Dow Street, University of Dundee, Dundee DD1 5EH, UK
    EMBO J 22:5793-805. 2003

Research Grants

Scientific Experts

  • K Sayama
  • Giuseppe M Campo
  • Fons Aj van de Loo
  • Mark A Parker
  • Sandip Bhattacharyya
  • Zhao Hui Wu
  • Giichi Takaesu
  • K C Yeung
  • Marcello Arsura
  • Jun Ninomiya-Tsuji
  • Kunihiro Matsumoto
  • Emily Omori
  • Shizuo Akira
  • Min Xie
  • Michael D Schneider
  • Jae Hyuck Shim
  • Shintaro Sato
  • Matthew B Greenblatt
  • Maiko Inagaki
  • Rie Kajino-Sakamoto
  • Jae Young Kim
  • Yuji Mishina
  • Hideki Sanjo
  • Richard A Flavell
  • Sung Il Kim
  • Sankar Ghosh
  • Peter C F Cheung
  • Yoshihiro Komatsu
  • Betty Lamothe
  • Yechen Xiao
  • Sho Morioka
  • E Omori
  • Michael Karin
  • Jiwang Zhang
  • Laurie H Glimcher
  • Ping Hui Tseng
  • Joy L Jadrich
  • Hiroaki Sakurai
  • Ashok Kumar
  • Atsushi Matsuzawa
  • Yang Yu
  • Roger J Davis
  • Yisong Y Wan
  • Zhijian J Chen
  • Andreas Winkel
  • Hong Hsing Liu
  • Taisuke Kajino
  • Andrea Hoffmann
  • Alessandra Mancino
  • Zhongchen Song
  • Yong Wang
  • Shauna M Dauphinee
  • Lin Gao
  • K Matsumoto
  • Yang Chai
  • Gen Yamada
  • Akiko Suzuki
  • Ai Di Gu
  • Hittu Matta
  • Adebusola Alagbala Ajibade
  • Jun ichi Iwata
  • Liang Dai
  • Anahita Hamidi
  • Min Wu
  • Christina Eftychi
  • Edward M Schwarz
  • Jennifer H Jonason
  • Matthew J Hilton
  • REGIS J O'KEEFE
  • Nicolas Winssinger
  • Jeroen Geurts
  • Dirk A Ridder
  • Yibin Yang
  • Jennifer A Rochira
  • Shashi Kant
  • Seda Çöl Arslan
  • Cinthia C Stempin
  • Neesar Ahmed
  • Yasuhiro Yamanaka
  • Shigeto Miura
  • N Vanlangenakker
  • Kamalakannan Rajasekaran
  • Roland Scholz
  • Shephali Bhatnagar
  • Sayaka Inokuchi
  • Yihui Fan
  • Lea M Gunnell
  • Bryant G Darnay
  • Joseph M Verdi
  • Tamara L Adams

Detail Information

Publications122 found, 100 shown here

  1. doi TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer
    Kira Bettermann
    Department of Internal Medicine III, University Hospital RWTH Aachen, D 52074 Aachen, Germany
    Cancer Cell 17:481-96. 2010
    The MAP3-kinase TGF-beta-activated kinase 1 (TAK1) critically modulates innate and adaptive immune responses and connects cytokine stimulation with activation of inflammatory signaling pathways...
  2. pmc A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation
    James Schuman
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee 53226, USA
    Blood 113:4566-74. 2009
    The kinase TAK1 is essential for T-cell receptor (TCR)-mediated nuclear factor kappaB (NF-kappaB) activation and T-cell development...
  3. doi TNF-α/Fas-RIP-1-induced cell death signaling separates murine hematopoietic stem cells/progenitors into 2 distinct populations
    Yechen Xiao
    Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL 60153, USA
    Blood 118:6057-67. 2011
    ..progenitor cells (HSPCs) by examining their contributions to the development of bone marrow failure syndromes in Tak1-knockout mice (Tak1(-/-))...
  4. pmc Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions
    Francesco J Conti
    The Scripps Research Institute, Department of Cell Biology and Institute of Childhood and Neglected Diseases, La Jolla, CA 92037, USA
    Development 136:3597-606. 2009
    ..We conclude that talin 1 and 2 are crucial for skeletal muscle development, where they regulate myoblast fusion, sarcomere assembly and the maintenance of MTJs...
  5. pmc Essential role of TAK1 in thymocyte development and activation
    Hong Hsing Liu
    Department of Molecular Biology and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 103:11677-82. 2006
    The protein kinase TAK1 mediates the activation of NF-kappaB in response to stimulation by proinflammatory cytokines and microbial pathogens in the innate immunity pathways...
  6. ncbi Disabled-2 (Dab2) mediates transforming growth factor beta (TGFbeta)-stimulated fibronectin synthesis through TGFbeta-activated kinase 1 and activation of the JNK pathway
    Barbara A Hocevar
    Department of Cell Biology, Cleveland Clinic Lerner College of Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 280:25920-7. 2005
    ..that TGFbeta treatment stimulates the association of Dab2 with the mitogen-activated protein kinase kinase kinase, TAK1. Attenuation of cellular TAK1 levels by transient double-stranded RNA oligonucleotide transfection as well as ..
  7. pmc Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1
    Sandra Blanco
    Programa de Oncología Translacional, Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca E 37007, Spain
    Mol Cell Biol 27:7273-83. 2007
    ..Hypoxia induces an increase in the activity of TAK1, an atypical mitogen-activated protein kinase kinase kinase (MAPKKK), which responds to oxidative stress by ..
  8. ncbi Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis
    Yoshihiro Komatsu
    Center for Animal Resources and Development, Graduate School of Molecular and Genomic Pharmacy, Kumamoto University, Honjo 2 2 1, Kumamoto 860 0811, Japan
    Mech Dev 119:239-49. 2002
    ..kinase-1 binding protein-1 (TAB1) was identified as a molecule that activates TGF-beta activated kinase-1 (TAK1)...
  9. ncbi Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation
    Marcello Arsura
    Department of Pharmacology, University of Tennessee College of Medicine, Memphis 38163, USA
    Oncogene 22:412-25. 2003
    ..In turn, the activation of IKK following TGF-beta1 treatment is mediated by the TAK1 kinase...
  10. pmc Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha
    Peter C F Cheung
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, Dow Street, University of Dundee, Dundee DD1 5EH, UK
    EMBO J 22:5793-805. 2003
    TAB1, a subunit of the kinase TAK1, was phosphorylated by SAPK2a/p38alpha at Ser423, Thr431 and Ser438 in vitro...
  11. ncbi Transforming growth factor-beta-activated kinase-1 (TAK1), a MAP3K, interacts with Smad proteins and interferes with osteogenesis in murine mesenchymal progenitors
    Andrea Hoffmann
    Gesellschaft fur Biotechnologische Forschung, Signal Transduction and Gene Regulation, Mascheroder Weg 1, 38124 Braunschweig, Germany
    J Biol Chem 280:27271-83. 2005
    b>TAK1 (transforming growth factor-beta-activated kinase-1), a MAP3K with considerable sequence similarity to Raf-1 and MEKK-1, has been identified as a transforming growth factor-beta/bone morphogenetic protein (BMP)-activated cytosolic ..
  12. ncbi Essential function for the kinase TAK1 in innate and adaptive immune responses
    Shintaro Sato
    Akira Innate Immunity Project, Exploratory Research for Advanced Technology, Japan Science and Technology Agency
    Nat Immunol 6:1087-95. 2005
    ..Here we generated mouse strains with conditional expression of a Map3k7 allele encoding part of TAK1...
  13. pmc TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB
    Noriyuki Uemura
    Department of Molecular Biology, Graduate School of Science, Nagoya University, Nagoya 464 8602, Japan
    J Biol Chem 281:7863-72. 2006
    ..Here we demonstrate that TAK1 mitogen-activated protein kinase kinase kinase and TAK1-binding protein 2 (TAB2), together with TRAF6, are ..
  14. ncbi The TGF beta activated kinase TAK1 regulates vascular development in vivo
    Joy L Jadrich
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Development 133:1529-41. 2006
    TGFbeta activated kinase 1 (TAK1) is a MAPKKK that in cell culture systems has been shown to act downstream of a variety of signaling molecules, including TGFbeta...
  15. pmc TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis
    Emily Omori
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina 27695 7633, USA
    J Biol Chem 281:19610-7. 2006
    Transforming growth factor beta-activated kinase 1 (TAK1) functions downstream of inflammatory cytokines to activate c-Jun N-terminal kinase (JNK) as well as NF-kappaB in several cell types...
  16. pmc A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway
    Min Xie
    Center for Cardiovascular Development, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:17378-83. 2006
    TGF-beta-activated kinase-1 (TAK1), also known as MAPKK kinase-7 (MAP3K7), is a candidate effector of multiple circuits in cardiac biology and disease...
  17. pmc TAK1-dependent signaling requires functional interaction with TAB2/TAB3
    Arnaud Besse
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 282:3918-28. 2007
    Transforming growth factor beta-activated kinase 1 (TAK1), a member of the MAPKKK family, was initially described to play an essential role in the transforming growth factor beta-signaling pathway, but recent evidence has emerged ..
  18. pmc TAK1 MAPK kinase kinase mediates transforming growth factor-beta signaling by targeting SnoN oncoprotein for degradation
    Taisuke Kajino
    Department of Molecular Biology, Graduate School of Science, Nagoya University, Nagoya 464 8602, Japan
    J Biol Chem 282:9475-81. 2007
    ..Here, we report the role of TAK1 as a SnoN protein kinase...
  19. ncbi Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2
    Suntaek Hong
    Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892 50551, USA
    Nat Immunol 8:504-13. 2007
    ..that the TGF-beta-induced signaling protein Smad7 bound to TAB2 and TAB3, which are adaptors that link the kinase TAK1 to 'upstream' regulators in the proinflammatory tumor necrosis factor (TNF) signaling pathway...
  20. ncbi Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex
    Heidi Mendoza
    MRC Protein Phosphorylation Unit, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 409:711-22. 2008
    The protein kinase TAK1 (transforming growth factor-beta-activated kinase 1), which has been implicated in the activation of MAPK (mitogen-activated protein kinase) cascades and the production of inflammatory mediators by LPS (..
  21. pmc A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation
    Mizuho Hasegawa
    Department of Pathology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    EMBO J 27:373-83. 2008
    ..Instead, polyubiquitination of RICK was found to mediate the recruitment of TAK1, a kinase that was found to be essential for Nod1-induced signaling...
  22. pmc Homeostatic interactions between MEKK3 and TAK1 involved in NF-kappaB signaling
    Yuwei Di
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Cell Signal 20:705-13. 2008
    ..of the mitogen-activated protein kinase kinase kinase (MAP3K) family including MEKK3 and TGFbeta-activating kinase (TAK1) play nonredundant roles in activation of the NF-kappaB transcription factor...
  23. pmc Protein phosphatase 2A is a negative regulator of transforming growth factor-beta1-induced TAK1 activation in mesangial cells
    Sung Il Kim
    Renal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 283:10753-63. 2008
    b>TAK1 (transforming growth factor (TGF)-beta-activated kinase 1) is a serine/threonine kinase that is rapidly activated by TGF-beta1 and plays a vital function in its signal transduction...
  24. pmc TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice
    Minghui Tang
    Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL 60153, USA
    J Exp Med 205:1611-9. 2008
    Transforming growth factor beta-activated kinase 1 (TAK1), a member of the MAPKKK family, is a key mediator of proinflammatory and stress signals...
  25. pmc Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis
    Rie Kajino-Sakamoto
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC 27695, USA
    J Immunol 181:1143-52. 2008
    Recent studies have revealed that TAK1 kinase is an essential intermediate in several innate immune signaling pathways...
  26. pmc Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point
    Qinghang Liu
    Department of Pediatrics, University of Cincinnati, Cincinnati Children s Hospital Medical Center, and the Howard Hughes Medical Institute, Cincinnati, Ohio 45229, USA
    Nat Cell Biol 11:154-61. 2009
    ..Here we performed a yeast two-hybrid screen with RCAN1 as bait, identifying TAK1 binding protein 2 (TAB2) as an interacting partner...
  27. pmc TNF-like weak inducer of apoptosis (TWEAK) activates proinflammatory signaling pathways and gene expression through the activation of TGF-beta-activated kinase 1
    Mukesh Kumar
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Immunol 182:2439-48. 2009
    ..In this study, we tested the hypothesis that TAK1 (TGF-beta-activated kinase 1) is involved in TWEAK-induced activation of NF-kappaB and MAPK and expression of ..
  28. pmc Direct activation of protein kinases by unanchored polyubiquitin chains
    Zong Ping Xia
    Department of Molecular Biology, University of Texas, Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Nature 461:114-9. 2009
    ..as UBE2N) and UEV1A (UBE2V1) to catalyse Lys 63-linked polyubiquitination, which activates the TAK1 (also known as MAP3K7) kinase complex...
  29. pmc Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines
    Ping Hui Tseng
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Department of Pathology, School of Medicine, University of California San Diego, La Jolla, California, USA
    Nat Immunol 11:70-5. 2010
    ..Inhibition of degradative ubiquitination of TRAF3 prevented the expression of all proinflammatory cytokines without affecting the interferon response...
  30. pmc Transforming growth factor beta-activated kinase 1 (TAK1) kinase adaptor, TAK1-binding protein 2, plays dual roles in TAK1 signaling by recruiting both an activator and an inhibitor of TAK1 kinase in tumor necrosis factor signaling pathway
    Peter Broglie
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina 27695, USA
    J Biol Chem 285:2333-9. 2010
    Transforming growth factor beta-activated kinase 1 (TAK1) kinase is an indispensable signaling intermediate in tumor necrosis factor (TNF), interleukin 1, and Toll-like receptor signaling pathways...
  31. pmc Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation
    Yihui Fan
    Laboratory of Medical Genetics, Harbin Medical University, Harbin 150081, China
    J Biol Chem 285:5347-60. 2010
    Transforming growth factor-beta-activated kinase 1 (TAK1) plays an essential role in the tumor necrosis factor alpha (TNFalpha)- and interleukin-1beta (IL-1beta)-induced IkappaB kinase (IKK)/nuclear factor-kappaB (NF-kappaB) and c-Jun N-..
  32. doi Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor
    Meixiao Long
    Department of Immunobiology and Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 31:921-31. 2009
    ..Hence, NF-kappaB signaling pathway is a key regulator of Foxp3 expression during natural Treg cell development...
  33. pmc Autoactivation of transforming growth factor beta-activated kinase 1 is a sequential bimolecular process
    Roland Scholz
    Department of Biology, Institute of Cell Biology, ETH Zurich, 8093 Zurich, Switzerland
    J Biol Chem 285:25753-66. 2010
    Transforming growth factor-beta-activated kinase 1 (TAK1), an MAP3K, is a key player in processing a multitude of inflammatory stimuli. TAK1 autoactivation involves the interplay with TAK1-binding proteins (TAB), e.g...
  34. pmc The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice
    Matthew B Greenblatt
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 120:2457-73. 2010
    ..Among the MAPK kinase kinase (MAP3K) family, we identified TGF-beta-activated kinase 1 (TAK1; also known as MAP3K7) as the critical activator upstream of p38 in osteoblasts...
  35. pmc Ablation of TAK1 upregulates reactive oxygen species and selectively kills tumor cells
    Emily Omori
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina 27695 7633, USA
    Cancer Res 70:8417-25. 2010
    b>TAK1 kinase activates multiple transcription factors and regulates the level of reactive oxygen species (ROS). We have previously reported that ablation of TAK1 in keratinocytes causes hypersensitivity to ROS-induced cell apoptosis...
  36. pmc A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage
    Yibin Yang
    Departments of Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Mol Cell Biol 31:2774-86. 2011
    ..we show that DNA damage stimulates the formation of a cytosolic complex containing ATM, NEMO (IKKγ), RIP1, and TAK1. We find that RIP1 is modified by SUMO-1 and ubiquitin in response to DNA damage and demonstrate that modified RIP1 ..
  37. pmc Transforming growth factor-beta-activated kinase 1 regulates natural killer cell-mediated cytotoxicity and cytokine production
    Kamalakannan Rajasekaran
    Laboratory of Molecular Immunology and Immunotherapy, Blood Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 286:31213-24. 2011
    ..Here we show that transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1) is abundantly present in NK cells, and activation via NKG2D results in its phosphorylation...
  38. pmc The prevalence of TNFα-induced necrosis over apoptosis is determined by TAK1-RIP1 interplay
    Seda Çöl Arslan
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    PLoS ONE 6:e26069. 2011
    ..Here, we show that in cells lacking TGFβ-activated Kinase-1 (TAK1) expression, catalytically active Receptor Interacting Protein 1 (RIP1)-dependent programmed necrosis overrides ..
  39. pmc Polyubiquitination of transforming growth factor β (TGFβ)-associated kinase 1 mediates nuclear factor-κB activation in response to different inflammatory stimuli
    Anahita Hamidi
    Ludwig Institute for Cancer Research, Uppsala University, Uppsala, Sweden
    J Biol Chem 287:123-33. 2012
    ..The TGFβ-associated kinase 1 (TAK1) is an upstream regulator of NF-κB signaling...
  40. pmc Epithelial transforming growth factor β-activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species
    Emily Omori
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC 27695 7633, USA
    Proc Natl Acad Sci U S A 109:3365-70. 2012
    ..Transforming growth factor β-activated kinase 1 (TAK1) is a signaling intermediate of innate immune signaling pathways and is critically involved in the redox regulation ..
  41. pmc Myeloid TAKI [corrected] acts as a negative regulator of the LPS response and mediates resistance to endotoxemia
    Christina Eftychi
    Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, Vari, Greece
    PLoS ONE 7:e31550. 2012
    TGFβ-activated kinase 1 (TAK1), a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family, is considered a key intermediate in a multitude of innate immune signaling pathways...
  42. pmc Suppression of Tak1 promotes prostate tumorigenesis
    Min Wu
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Cancer Res 72:2833-43. 2012
    ..1. The MAP3K7 gene, which encodes TGF-β activated kinase-1 (Tak1), is a putative prostate tumor suppressor gene within this ..
  43. pmc TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration
    Sho Morioka
    Department of Molecular Biology, Graduate School of Science, Nagoya University, Nagoya, Japan
    Blood 120:3846-57. 2012
    TGF-β activated kinase 1 (TAK1) is a mediator of various cytokine signaling pathways. Germline deficiency of Tak1 causes multiple abnormalities, including dilated blood vessels at midgestation...
  44. ncbi Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction
    K Yamaguchi
    Department of Molecular Biology, Faculty of Science, Nagoya University, Japan
    Science 270:2008-11. 1995
    ..A genetic selection based on a MAPK pathway in yeast was used to identify a mouse protein kinase (TAK1) distinct from other members of the MAPKKK family...
  45. ncbi TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway
    G Takaesu
    Department of Molecular Biology, Graduate School of Science, Nagoya University and CREST, Japan
    Mol Cell 5:649-58. 2000
    The TAK1 MAPKKK mediates activation of JNK and NF-KB in the IL-1-activated signaling pathway. Here we report the identification of TAB2, a novel intermediate in the IL-1 pathway that functionally links TAK1 to TRAF6...
  46. ncbi Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes
    Axel Thiefes
    Institute of Pharmacology, Medical School Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    J Biol Chem 280:27728-41. 2005
    ..fibroblasts were infected with retroviruses encoding TAK1K63W, an inactive mutant of the protein kinase TAK1. Expression of this protein inhibited tumor necrosis factor (TNF)-induced activation of NFkappaB, JNK, and p38 MAPK ..
  47. pmc TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
    Jae Hyuck Shim
    Section of Immunobiology and Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Genes Dev 19:2668-81. 2005
    TGF-beta-activated kinase 1 (TAK1), a member of the MAPKKK family, is thought to be a key modulator of the inducible transcription factors NF-kappaB and AP-1 and, therefore, plays a crucial role in regulating the genes that mediate ..
  48. ncbi The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function
    Yisong Y Wan
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Immunol 7:851-8. 2006
    The kinase TAK1 is critical for innate and B cell immunity. The function of TAK1 in T cells is unclear, however...
  49. pmc TAK1 is a central mediator of NOD2 signaling in epidermal cells
    Jae Young Kim
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC 27695, USA
    J Biol Chem 283:137-44. 2008
    ..Here we show that transforming growth factor beta-activated kinase 1 (TAK1) is an essential intermediate of NOD2 signaling...
  50. pmc TAK1 regulates reactive oxygen species and cell death in keratinocytes, which is essential for skin integrity
    Emily Omori
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina 27695 7633, USA
    J Biol Chem 283:26161-8. 2008
    Mice with a keratinocyte-specific deletion of Tak1 exhibit severe skin inflammation due to hypersensitivity to tumor necrosis factor (TNF) killing. Here we have examined the mechanisms underlying this hypersensitivity...
  51. pmc TAK1-binding protein 1, TAB1, mediates osmotic stress-induced TAK1 activation but is dispensable for TAK1-mediated cytokine signaling
    Maiko Inagaki
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina 27695, USA
    J Biol Chem 283:33080-6. 2008
    b>TAK1 kinase is an indispensable intermediate in several cytokine signaling pathways including tumor necrosis factor, interleukin-1, and transforming growth factor-beta signaling pathways...
  52. doi Requirement of transforming growth factor beta-activated kinase 1 for transforming growth factor beta-induced alpha-smooth muscle actin expression and extracellular matrix contraction in fibroblasts
    Xu Shi-Wen
    University College London Royal Free Campus, London, UK
    Arthritis Rheum 60:234-41. 2009
    ..The present study was undertaken to assess whether TGFbeta-activated kinase 1 (TAK1) acts downstream of FAK/Src to mediate fibrogenic responses in fibroblasts.
  53. pmc NRAGE: a potential rheostat during branching morphogenesis
    George N Nikopoulos
    Maine Medical Center Research Institute, Center for Molecular Medicine, Scarborough, ME 04074, USA
    Mech Dev 126:337-49. 2009
    ..Our results suggested that in early kidney development NRAGE might have multiple roles during renal branching morphogenesis through association with both the BMP and GDNF signaling pathways...
  54. pmc TAK1 kinase determines TRAIL sensitivity by modulating reactive oxygen species and cIAP
    S Morioka
    Department of Molecular Biology, Nagoya University, Japan
    Oncogene 28:2257-65. 2009
    ..The mechanism that determines sensitivity to TRAIL-killing is still elusive. Here we report that deletion of TAK1 kinase greatly increased activation of caspase-3 and cell death after TRAIL stimulation in keratinocytes, ..
  55. pmc TAK1 is an essential regulator of BMP signalling in cartilage
    Jae Hyuck Shim
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    EMBO J 28:2028-41. 2009
    TGFbeta activated kinase 1 (TAK1), a member of the MAPKKK family, controls diverse functions ranging from innate and adaptive immune system activation to vascular development and apoptosis...
  56. pmc Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis
    Sayaka Inokuchi
    Department of Medicine, School of Medicine, University of California San Diego, La Jolla, CA 92093 0702, USA
    Proc Natl Acad Sci U S A 107:844-9. 2010
    TGF-beta-activated kinase 1 (TAK1) is a MAP3K family member that activates NF-kappaB and JNK via Toll-like receptors and the receptors for IL-1, TNF-alpha, and TGF-beta...
  57. pmc NF-kappaB activation in T cells requires discrete control of IkappaB kinase alpha/beta (IKKalpha/beta) phosphorylation and IKKgamma ubiquitination by the ADAP adapter protein
    Rupa Srivastava
    Department of Laboratory Medicine and Pathology, Center for Immunology, Masonic Cancer Center, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Biol Chem 285:11100-5. 2010
    ..In this study, we identify a novel site in ADAP that is critical for association with the TAK1 kinase. ADAP is critical for recruitment of TAK1 and the CBM complex, but not IKK, to protein kinase C-theta...
  58. pmc TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways
    Lea M Gunnell
    Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester, Rochester, NY, USA
    J Bone Miner Res 25:1784-97. 2010
    ..TGF-beta activated kinase 1 (TAK1) is a MAP3K activated by TGF-beta, BMP, and other mitogen-activated protein kinase (MAPK) signaling components...
  59. pmc Inflammatory mediator TAK1 regulates hair follicle morphogenesis and anagen induction shown by using keratinocyte-specific TAK1-deficient mice
    Koji Sayama
    Department of Dermatology, Ehime University Graduate School of Medicine, Ehime, Japan
    PLoS ONE 5:e11275. 2010
    ..By comparing keratinocyte-specific TAK1-deficient mice (Map3k7(fl/fl)K5-Cre) with control mice, we found that the number of hair germs (hair follicles precursors) in Map3k7(fl/..
  60. pmc TGF-beta-activated kinase 1 signaling maintains intestinal integrity by preventing accumulation of reactive oxygen species in the intestinal epithelium
    Rie Kajino-Sakamoto
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC 27695, USA
    J Immunol 185:4729-37. 2010
    ..In this article, we report that TGF-β-activated kinase 1 (TAK1) is a key regulator of ROS in the intestinal epithelium...
  61. pmc cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production
    N Vanlangenakker
    Department for Molecular Biomedical Research, VIB, Technologiepark 927, Zwijnaarde Ghent 9052, Belgium
    Cell Death Differ 18:656-65. 2011
    ..of RIP1 allows it to bind to the pro-survival kinase transforming growth factor-β-activated kinase 1 (TAK1) which prevents it from activating caspase-8-dependent death, a process reverted by the de-ubiquitinase CYLD...
  62. pmc The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation
    Neesar Ahmed
    Karmanos Cancer Institute, Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Nat Immunol 12:1176-83. 2011
    ..complex sequentially cleaved Lys63-linked ubiquitin chains and catalyzed Lys48-linked ubiquitination on the kinase Tak1 to terminate inflammatory signaling via tumor necrosis factor...
  63. pmc TAK1 negatively regulates NF-κB and p38 MAP kinase activation in Gr-1+CD11b+ neutrophils
    Adebusola Alagbala Ajibade
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
    Immunity 36:43-54. 2012
    ..Specific deletion of TAK1 (Map3k7(ΔM/ΔM)) led to development of splenomegaly and lymphomegaly associated with neutrophilia...
  64. pmc Modulation of noncanonical TGF-β signaling prevents cleft palate in Tgfbr2 mutant mice
    Jun ichi Iwata
    Center for Craniofacial Molecular Biology, Ostrow School of Dentistry, University of Southern California, Los Angeles, California 90033, USA
    J Clin Invest 122:873-85. 2012
    ..of TGF-β2 and TGF-β receptor type III (TβRIII); activation of a TβRI/TβRIII-mediated, SMAD-independent, TRAF6/TAK1/p38 signaling pathway; and defective cell proliferation in the palatal mesenchyme...
  65. doi TAK1, more than just innate immunity
    Liang Dai
    Division of Molecular and Cell Biology, School of Biological Sciences, Nanyang Technological University, Singapore
    IUBMB Life 64:825-34. 2012
    Transforming growth factor β-activated kinase 1 (TAK1) is a key regulator of the innate immunity and the proinflammatory signaling pathway...
  66. pmc TAK1 is essential for osteoclast differentiation and is an important modulator of cell death by apoptosis and necroptosis
    Betty Lamothe
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Mol Cell Biol 33:582-95. 2013
    Transforming growth factor β (TGF-β)-activated kinase 1 (TAK1), a mitogen-activated protein 3 (MAP3) kinase, plays an essential role in inflammation by activating the IκB kinase (IKK)/nuclear factor κB (NF-κB) and stress kinase (p38 ..
  67. pmc TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages
    Lin Gao
    Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester, Rochester, NY, USA
    J Cell Sci 126:5704-13. 2013
    b>TAK1 is a MAP3K that mediates non-canonical TGF-β and BMP signaling...
  68. ncbi Transforming growth factor-beta-activated kinase 1 is essential for differentiation and the prevention of apoptosis in epidermis
    Koji Sayama
    Department of Dermatology, Ehime University School of Medicine, Ehime 791 0295, Japan
    J Biol Chem 281:22013-20. 2006
    ..To test this, we generated keratinocyte-specific TAK1-deficient mice from Map3k7(flox/flox) mice and K5-Cre mice...
  69. ncbi TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells
    Shintaro Sato
    Akira Innate Immunity Project, Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Int Immunol 18:1405-11. 2006
    Transforming growth factor (TGF)-beta-activating kinase 1 (TAK1) is critical for Toll-like receptor- and tumor necrosis factor-mediated cellular responses...
  70. pmc TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells
    Griselda Herrero-Martin
    Cell Signalling Department, Centro Andaluz de Biologia Molecular y Medicina Regenerativa CABIMER, Consejo Superior de Investigaciones Cientificas, Avenida Americo Vespucio s n, Sevilla, Spain
    EMBO J 28:677-85. 2009
    ..Ca(2+)/calmodulin-dependent kinase kinase-beta, but depends on transforming growth factor-beta-activating kinase 1 (TAK1) and TAK1-binding subunit 2...
  71. pmc Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex
    Atsushi Matsuzawa
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
    Science 321:663-8. 2008
    ..This two-stage signaling mechanism may apply to other innate immune receptors, accounting for spatial and temporal separation of MAPK and IKK signaling...
  72. pmc Kaposi's sarcoma associated herpesvirus encoded viral FLICE inhibitory protein K13 activates NF-κB pathway independent of TRAF6, TAK1 and LUBAC
    Hittu Matta
    Jane Anne Nohl Division of Hematology and Center for the Study of Blood Diseases, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America
    PLoS ONE 7:e36601. 2012
    ..Recent studies have implicated TRAF6, TAK1 and linear ubiquitin chains assembled by a linear ubiquitin chain assembly complex (LUBAC) consisting of HOIL-1, ..
  73. doi Transcription factor Sox11 is essential for both embryonic and adult neurogenesis
    Yong Wang
    School of Life Sciences, Arizona State University, Tempe, Arizona, USA
    Dev Dyn 242:638-53. 2013
    ..Although neurogenesis is fundamental to brain development and function, our understanding of the molecular mechanisms that regulate neurogenesis is still limited...
  74. doi SASH1 is a scaffold molecule in endothelial TLR4 signaling
    Shauna M Dauphinee
    Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada
    J Immunol 191:892-901. 2013
    ..Sash1 is expressed across all microvascular beds and functions as a scaffold molecule to independently bind TRAF6, TAK1, IκB kinase α, and IκB kinase β...
  75. doi Toll-like receptor 4 signalling is specifically TGF-beta-activated kinase 1 independent in synovial fibroblasts
    Jeroen Geurts
    Department of Rheumatology, Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Rheumatology (Oxford) 50:1216-25. 2011
    ..In this study, we sought to determine the role of the MAP3K TGF-β-activated kinase 1 (TAK1) in cytokine and TLR-mediated signalling.
  76. pmc TAK1 in brain endothelial cells mediates fever and lethargy
    Dirk A Ridder
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lubeck, 23562 Lübeck, Germany
    J Exp Med 208:2615-23. 2011
    ..We show that expression of the MAP kinase kinase kinase TAK1 in brain endothelial cells is needed for interleukin 1β (IL-1β)-induced COX-2 production...
  77. pmc Requirements of transcription factor Smad-dependent and -independent TGF-β signaling to control discrete T-cell functions
    Ai Di Gu
    Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 109:905-10. 2012
    ..Therefore, Smad-dependent and -independent TGF-β signaling discretely controls non-Treg and Treg function to modulate immune tolerance and immune homeostasis...
  78. pmc I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection
    Alessandra Mancino
    Centre d Immunologie de Marseille Luminy CIML, Aix Marseille Universite, UM2, Marseille, France
    EMBO J 32:816-28. 2013
    ..This presents a unique role for IKKα in dampening inflammation while simultaneously promoting adaptive immunity that could have important implications for the development of new vaccine adjuvants and treatment of autoimmune diseases...
  79. pmc Mice with Tak1 deficiency in neural crest lineage exhibit cleft palate associated with abnormal tongue development
    Zhongchen Song
    Department of Periodontology, Ninth People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China
    J Biol Chem 288:10440-50. 2013
    ..In this study, we investigated the function of TGFβ activated kinase 1 (Tak1), a key regulator of Smad-independent TGFβ signaling in palate development...
  80. ncbi Regulation of the interleukin-1-induced signaling pathways by a novel member of the protein phosphatase 2C family (PP2Cepsilon)
    Ming Guang Li
    Department of Biochemistry, Institute of Development, Aging, and Cancer, Tohoku University, 4 1 Seiryomachi, Aoba ku, Sendai 980 8575, Japan
    J Biol Chem 278:12013-21. 2003
    Although TAK1 signaling plays essential roles in eliciting cellular responses to interleukin-1 (IL-1), a proinflammatory cytokine, how the IL-1-TAK1 signaling pathway is positively and negatively regulated remains poorly understood...
  81. ncbi Short-term lineage analysis of dorsally derived Olig3 cells in the developing spinal cord
    Lei Ding
    Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, 5 1 Higashiyama, Myodaiji, Okazaki, 444 8787, Japan
    Dev Dyn 234:622-32. 2005
    ..Dorsal midline cells were also LacZ-positive during development. These findings suggest that dorsal Olig3 cells contribute to dorsal midline cells and commissural interneurons at intermediate and ventral levels...
  82. ncbi X-linked inhibitor of apoptosis (XIAP) inhibits c-Jun N-terminal kinase 1 (JNK1) activation by transforming growth factor beta1 (TGF-beta1) through ubiquitin-mediated proteosomal degradation of the TGF-beta1-activated kinase 1 (TAK1)
    Swayamjot Kaur
    Department of Pharmacology, University of Tennessee Cancer Institute UTCI, University of Tennessee Health Science Center, College of Medicine, University of Tennessee, Memphis, Tennessee 38163, USA
    J Biol Chem 280:38599-608. 2005
    ..of XIAP gene expression in response to TGF-beta1 treatment and forms a TGF-beta1-inducible complex with TAK1. Furthermore, we show that the RING domain of XIAP mediates TAK1 polyubiquitination, which then targets this ..
  83. pmc PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1
    Hisaaki Shinohara
    Laboratory for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa 230 0045, Japan
    J Exp Med 202:1423-31. 2005
    ..b>TAK1 interacts with the phosphorylated CARMA1 (also known as caspase recruitment domain [CARD]11, Bimp3) and this ..
  84. ncbi Yersinia outer protein P suppresses TGF-beta-activated kinase-1 activity to impair innate immune signaling in Yersinia enterocolitica-infected cells
    Rudolf Haase
    Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Munich, Germany
    J Immunol 175:8209-17. 2005
    ..Accordingly, YopP efficiently impaired the activities of TGF-beta-activated kinase-1 (TAK1) in infected cells. TAK1 is an important activator of the IkappaB kinase complex in the TLR signaling cascade...
  85. ncbi Interleukin-1 (IL-1)-induced TAK1-dependent Versus MEKK3-dependent NFkappaB activation pathways bifurcate at IL-1 receptor-associated kinase modification
    Jianhong Yao
    Department of Immunology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 282:6075-89. 2007
    ..IRAK modification mutants, we uncovered two parallel IL-1-mediated signaling pathways for NFkappaB activation, TAK1-dependent and MEKK3-dependent, respectively. These two pathways bifurcate at the level of IRAK modification...
  86. pmc Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase
    Olga Göransson
    Division for Diabetes, Metabolism and Endocrinology, Department of Experimental Medical Science, Lund University, Lund, Sweden
    J Biol Chem 282:32549-60. 2007
    ..acetyl-CoA carboxylase (ACC), effects that are completely abolished in AMPK-alpha1(-/-)alpha2(-/-) cells but not in TAK1(-/-) mouse embryonic fibroblasts...
  87. pmc Phosphorylation of Thr-178 and Thr-184 in the TAK1 T-loop is required for interleukin (IL)-1-mediated optimal NFkappaB and AP-1 activation as well as IL-6 gene expression
    Yang Yu
    Texas Children s Cancer Center, Department of Pediatrics, Center for Cardiovascular Development, Department of Medicine, and Michael E DeBakey Department of Surgery, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030
    J Biol Chem 283:24497-505. 2008
    b>TAK1 (transforming growth factor-beta-activated kinase 1), a mitogen-activated protein kinase kinase kinase, is activated by various cytokines, including interleukin-1 (IL-1)...
  88. pmc Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein
    Xueqiao Liu
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:11335-9. 2008
    ..Activation of NF-kappaB by a virion tegument protein that is delivered into the host cell cytoplasm during viral entry represents a mechanism for activation of this pathway by a virus...
  89. doi Wnt-ligand-dependent interaction of TAK1 (TGF-beta-activated kinase-1) with the receptor tyrosine kinase Ror2 modulates canonical Wnt-signalling
    Andreas Winkel
    Helmholtz Centre for Infection Research HZI, Inhoffenstr 7, 38124 Braunschweig, Germany
    Cell Signal 20:2134-44. 2008
    ..We have identified two novel factors interacting with the Ror2 intracellular domain. TAK1 (TGF-beta activated kinase 1), a MAP3K, interacts with Ror2 and phosphorylates its intracellular carboxyterminal ..
  90. doi CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages
    Xingguang Liu
    Institute of Immunology and National Key Laboratory of Medical Immunology, Second Military Medical University, Shanghai, China
    Blood 112:4961-70. 2008
    ..pathways, CaMKII-alpha can directly bind and phosphorylate transforming growth factor beta-activated kinase 1 (TAK1) and IFN regulatory factor 3 (IRF3; serine on 386) via the N-terminal part of its regulatory domain...
  91. doi MAP3Ks as central regulators of cell fate during development
    Evisabel A Craig
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA
    Dev Dyn 237:3102-14. 2008
    ..This perspective reveals that some of these MAP3K effectors may have redundant functions, and also serve as unique nexus depending on the context of the signaling pathway...
  92. pmc Pharmacological postconditioning effect of muramyl dipeptide is mediated through RIP2 and TAK1
    Pierre Sicard
    King s College London British Heart Foundation Centre of Research Excellence, The Cardiovascular Division, The Rayne Institute, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Cardiovasc Res 83:277-84. 2009
    ..signals through receptor interacting protein-2 (RIP2) and tumour growth factor-beta-activated kinase-1 (TAK1). However, little is known about the RIP2/TAK1 pathway in the heart...
  93. pmc RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1
    Susie S Mikkelsen
    Institute of Medical Microbiology and Immunology, The Bartholin Building, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Biol Chem 284:10774-82. 2009
    ..We also observed that TRAF2 and TAK1 were essential for RIG-I-mediated activation of p38 MAPK...
  94. pmc Intestinal epithelial-derived TAK1 signaling is essential for cytoprotection against chemical-induced colitis
    Jae Young Kim
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina, United States of America
    PLoS ONE 4:e4561. 2009
    We have previously reported that intestinal epithelium-specific TAK1 deleted mice exhibit severe inflammation and mortality at postnatal day 1 due to TNF-induced epithelial cell death...
  95. doi Resistin up-regulates COX-2 expression via TAK1-IKK-NF-kappaB signaling pathway
    Jian Zhang
    Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, People s Republic of China
    Inflammation 33:25-33. 2010
    ..Moreover, we found that transforming growth factor-beta-activated kinase 1 (TAK1), a mitogen-activated protein kinase kinase kinase (MAPKKK), could be activated in response to resistin...
  96. pmc Helicobacter pylori CagA activates NF-kappaB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination
    Acacia Lamb
    Department of Biochemistry, College of Medicine, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    EMBO Rep 10:1242-9. 2009
    ..pylori virulence factor CagA and host protein transforming growth factor-beta-activated kinase 1 (TAK1) are essential for H. pylori-induced activation of NF-kappaB...
  97. pmc Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by NZF domains of TAB2 and TAB3
    Yusuke Sato
    Structural Biology Laboratory, Life Science Division, Synchrotron Radiation Research Organization, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan
    EMBO J 28:3903-9. 2009
    ..We therefore propose a mechanism for the recognition of Lys 63-linked polyubiquitin chains by TAB2 and TAB3 NZF domains in which diubiquitin units are specifically recognized by a single NZF domain...
  98. pmc Transforming growth factor-beta-activated kinase 1 is an essential regulator of myogenic differentiation
    Shephali Bhatnagar
    Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Biol Chem 285:6401-11. 2010
    ..We have tested the hypothesis that transforming growth factor-beta-activated kinase 1 (TAK1) is an important regulator of skeletal muscle formation...
  99. pmc Non-canonical β-catenin degradation mediates reactive oxygen species-induced epidermal cell death
    E Omori
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC 27695, USA
    Oncogene 30:3336-44. 2011
    ..Upregulation of the intact β-catenin blocked ROS accumulation and caspase activation. These results indicate that a feed-forward loop consisting of ROS, caspases activation and β-catenin degradation induces epidermal cell death...
  100. pmc Polyubiquitination events mediate polymethylmethacrylate (PMMA) particle activation of NF-kappaB pathway
    Yasuhiro Yamanaka
    Department of Orthopedic Surgery, Asahikawa Medical College, Asahikawa 078 8510, Japan
    J Biol Chem 286:23735-41. 2011
    ..this study, we report that PMMA particles activate the upstream transforming growth factor β-activated kinase-1 (TAK1), which is a key regulator of signal transduction cascades leading to activation of NF-κB and AP-1 factors...
  101. pmc A small peptide modeled after the NRAGE repeat domain inhibits XIAP-TAB1-TAK1 signaling for NF-κB activation and apoptosis in P19 cells
    Jennifer A Rochira
    University of Maine, Orono, Maine, United States of America
    PLoS ONE 6:e20659. 2011
    ..stimulated from BMP ligands, neurotrophin receptor-mediated MAGE homolog (NRAGE) binds and functions with the XIAP-TAK1-TAB1 complex to activate p38(MAPK) and induces apoptosis in cortical neural progenitors...

Research Grants2

  1. ROLE OF NF-KB IN TGF-B1 INDUCED APOPTOSIS OF HEPATOCYTES
    Marcello Arsura; Fiscal Year: 2005
    ..Furthermore, these findings will provide important insights into the role of NF- kappaB/Rel factors in the control of apoptosis of normal and transformed hepatocytes of potential clinical relevance. ..