Maoa

Summary

Gene Symbol: Maoa
Description: monoamine oxidase A
Alias: 1110061B18Rik, AA407771, amine oxidase [flavin-containing] A, MAO-A, monoamine oxidase type A
Species: mouse

Top Publications

  1. ncbi Behavioral characteristics of mice with genetic knockout of monoamine oxidase type A
    N K Popova
    Laboratory of Behavioral Phenogenetics, Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, Novosibirsk Centre National de la Recherche Scientifique, Institute Curie, Orsay, France
    Neurosci Behav Physiol 31:597-602. 2001
  2. ncbi Plasma membrane transporters of serotonin, dopamine, and norepinephrine mediate serotonin accumulation in atypical locations in the developing brain of monoamine oxidase A knock-outs
    O Cases
    Department of Physiology, Medical School, Teviot Place, Edinburgh EH8 9AG, Scotland
    J Neurosci 18:6914-27. 1998
  3. ncbi Postnatal regulation by monoamines of vasopressin expression in the neuroendocrine hypothalamus of MAO-A-deficient mice
    Claire Marie Vacher
    Laboratoire de Neurobiologie des Signaux Intercellulaires, UMR CNRS 7101, Universite Pierre et Marie Curie, 75252 Paris Cedex 05, France
    Eur J Neurosci 19:1110-4. 2004
  4. ncbi MAO(A) knockout mice are more susceptible to seizures but show reduced epileptogenesis
    G Campbell Teskey
    Behavioural Neuroscience Research Group, Department of Psychology, University of Calgary, Calgary, Alberta, Canada T2N 1N4
    Epilepsy Res 59:25-34. 2004
  5. ncbi Expression of Cux-1 and Cux-2 in the developing somatosensory cortex of normal and barrel-defective mice
    Arnaud Ferrere
    INSERM U616, Hopital de la Pitie Salpetriere, Paris, France
    Anat Rec A Discov Mol Cell Evol Biol 288:158-65. 2006
  6. pmc Novel monoamine oxidase A knock out mice with human-like spontaneous mutation
    Anna L Scott
    Department of Pharmacology and Pharmaceutical Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Neuroreport 19:739-43. 2008
  7. ncbi Oxidative stress-dependent sphingosine kinase-1 inhibition mediates monoamine oxidase A-associated cardiac cell apoptosis
    Dimitri Pchejetski
    INSERM U466, Toulouse Cedex 4, France
    Circ Res 100:41-9. 2007
  8. pmc Monoamine oxidase B prompts mitochondrial and cardiac dysfunction in pressure overloaded hearts
    Nina Kaludercic
    1 Neuroscience Institute, National Research Council of Italy, Padova, Italy
    Antioxid Redox Signal 20:267-80. 2014
  9. ncbi cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein
    C H Charles
    Department of Genetics, University of Illinois College of Medicine, Chicago 60612
    Oncogene 7:187-90. 1992
  10. pmc A transposon in Comt generates mRNA variants and causes widespread expression and behavioral differences among mice
    Zhengsheng Li
    Department of Anatomy and Neurobiology, Center for Integrative and Translational Genomics, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 5:e12181. 2010

Scientific Experts

  • Jeansok J Kim
  • N K Popova
  • D P Holschneider
  • M Bortolato
  • Alexandre Bonnin
  • Regis Grailhe
  • J C Shih
  • Z Yang
  • Tania Vitalis
  • Ann M Thompson
  • G C Teskey
  • C S Barr
  • Rainald Mossner
  • A Evrard
  • E A Ivanova
  • Kevin Chen
  • Isabelle Seif
  • Sean C Godar
  • Chi Chiu Wang
  • Nina Kaludercic
  • Anna L Scott
  • Junlin Zhang
  • I Seif
  • Patricia Gaspar
  • Xiao Ming Ou
  • Alexandra Rebsam
  • Hsiao Huei Wu
  • Houri Hintiryan
  • Christina H Liu
  • P Gaspar
  • Olivier Cases
  • Elvira Ganic
  • O Cases
  • Sharonda Harris
  • Jolene Ooi
  • Thomas F Denson
  • Chanpreet Singh
  • Adrian Sturza
  • Miyuki Kabayama
  • Hartmut Kuhn
  • Astrid Borchert
  • Christoph Ufer
  • Aslihan Ugun-Klusek
  • Ching Yan Chu
  • Kathleen L Gabrielson
  • Edwin W Lai
  • Karel Pacak
  • Nazareno Paolocci
  • Takahiro Nagayama
  • Eiki Takimoto
  • Fabio Di Lisa
  • David A Kass
  • Loai Alzghoul
  • Djahida Bedja
  • Rick C S Lin
  • Kimberly L Simpson
  • Ryan D Darling
  • Sergiy Libert
  • Zhi Qiang Wang
  • Paul R Pennington
  • Aiwu Cheng
  • G Hilaire
  • Zhengsheng Li
  • Olivier Lairez
  • Angelo Parini
  • Ming Shi
  • Gabriele Hampp
  • Vanessa Houades
  • Michael A Kiebish
  • Helene Bras
  • Denis Calise
  • E De Maeyer
  • Galina B Vishnivetskaya
  • Lea Stankovski
  • Dimitri Pchejetski
  • Arnaud Ferrere
  • Soh Agatsuma
  • Weihua Wu
  • Igor Rebrin
  • C Bou-Flores
  • N Salichon
  • V S Naumenko
  • A L Upton
  • A M Lajard
  • Claire Marie Vacher
  • Seita Yamashita
  • Ian Bowman
  • Michael S Bienkowski
  • Craig E Brown
  • Maxwell Bay

Detail Information

Publications95

  1. ncbi Behavioral characteristics of mice with genetic knockout of monoamine oxidase type A
    N K Popova
    Laboratory of Behavioral Phenogenetics, Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, Novosibirsk Centre National de la Recherche Scientifique, Institute Curie, Orsay, France
    Neurosci Behav Physiol 31:597-602. 2001
    Transgenic mice of line Tg8 were used to study the effects of deletion of the monoamine oxidase type A gene and the absence of the corresponding enzyme on behavior...
  2. ncbi Plasma membrane transporters of serotonin, dopamine, and norepinephrine mediate serotonin accumulation in atypical locations in the developing brain of monoamine oxidase A knock-outs
    O Cases
    Department of Physiology, Medical School, Teviot Place, Edinburgh EH8 9AG, Scotland
    J Neurosci 18:6914-27. 1998
    Genetic loss or pharmacological inhibition of monoamine oxidase A (MAOA) in mice leads to a large increase in whole-brain levels of serotonin (5-HT)...
  3. ncbi Postnatal regulation by monoamines of vasopressin expression in the neuroendocrine hypothalamus of MAO-A-deficient mice
    Claire Marie Vacher
    Laboratoire de Neurobiologie des Signaux Intercellulaires, UMR CNRS 7101, Universite Pierre et Marie Curie, 75252 Paris Cedex 05, France
    Eur J Neurosci 19:1110-4. 2004
    ..Together, these data show a marked region-specific sensitivity of AVP expression to NA and 5-HT during the postnatal period in the mouse hypothalamus...
  4. ncbi MAO(A) knockout mice are more susceptible to seizures but show reduced epileptogenesis
    G Campbell Teskey
    Behavioural Neuroscience Research Group, Department of Psychology, University of Calgary, Calgary, Alberta, Canada T2N 1N4
    Epilepsy Res 59:25-34. 2004
    ..We conclude that the high levels of neuroactive amines in the MAO(A) KO mice reorganize the brain to make the mice more susceptible to seizures but the remaining high levels of serotonin and norepinephrine likely inhibit epileptogenesis...
  5. ncbi Expression of Cux-1 and Cux-2 in the developing somatosensory cortex of normal and barrel-defective mice
    Arnaud Ferrere
    INSERM U616, Hopital de la Pitie Salpetriere, Paris, France
    Anat Rec A Discov Mol Cell Evol Biol 288:158-65. 2006
    ..We examined Cux-1 and Cux-2 in barrel-defective mouse strains, the VMAT2 KO, the MAOA KO, and the Adcyl 1(brl) strain...
  6. pmc Novel monoamine oxidase A knock out mice with human-like spontaneous mutation
    Anna L Scott
    Department of Pharmacology and Pharmaceutical Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Neuroreport 19:739-43. 2008
    ..mice [monoamine oxidase A knockout (MAOA KO)] harboring a spontaneous point nonsense mutation in exon 8 of the MAO A gene was serendipitously identified in a 129/SvEvTac colony...
  7. ncbi Oxidative stress-dependent sphingosine kinase-1 inhibition mediates monoamine oxidase A-associated cardiac cell apoptosis
    Dimitri Pchejetski
    INSERM U466, Toulouse Cedex 4, France
    Circ Res 100:41-9. 2007
    ..In addition, we provide the first evidence linking generation of reactive oxygen species with SphK1 inhibition. Finally, we propose sphingolipid metabolites as key mediators of postischemic/reperfusion cardiac injury...
  8. pmc Monoamine oxidase B prompts mitochondrial and cardiac dysfunction in pressure overloaded hearts
    Nina Kaludercic
    1 Neuroscience Institute, National Research Council of Italy, Padova, Italy
    Antioxid Redox Signal 20:267-80. 2014
    ..The potential pathogenetic role of the isoenzyme MAO-B in cardiac diseases is currently unknown. Moreover, it is has not been determined yet whether MAO activation can directly affect mitochondrial function...
  9. ncbi cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein
    C H Charles
    Department of Genetics, University of Illinois College of Medicine, Chicago 60612
    Oncogene 7:187-90. 1992
    ..Using affinity-purified antibodies, we have identified the 3CH134 protein in serum-stimulated Balb/c 3T3 cells and determined that it has a short half-life...
  10. pmc A transposon in Comt generates mRNA variants and causes widespread expression and behavioral differences among mice
    Zhengsheng Li
    Department of Anatomy and Neurobiology, Center for Integrative and Translational Genomics, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS ONE 5:e12181. 2010
    ..This study identifies the key sequence variant that leads to differences in Comt mRNA and protein levels among mice, and that modulates synaptic function and pharmacological and behavioral traits...
  11. ncbi Role of thalamic axons in the expression of H-2Z1, a mouse somatosensory cortex specific marker
    Y Gitton
    CNRS UMR 8542, Régionalisation Nerveuse, Ecole Normale Superieure, Paris, France
    Cereb Cortex 9:611-20. 1999
    ..For this purpose, we examined the pattern of H-2Z1 expression in perinatal cortical explant, in reeler mutant and MaoA deficient mice, or in animals which had received neonatal lesions affecting the somatosensory cortex or the ..
  12. pmc Monoamine oxidase A and A/B knockout mice display autistic-like features
    Marco Bortolato
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Int J Neuropsychopharmacol 16:869-88. 2013
    ..b>MAOA and A/B knockout (KO) mice display high 5-HT levels, particularly during early developmental stages...
  13. pmc Altered cerebellar organization and function in monoamine oxidase A hypomorphic mice
    Loai Alzghoul
    Program in Neuroscience, University of Mississippi Medical Center, Jackson, MS, USA
    Neuropharmacology 63:1208-17. 2012
    ..Our current findings suggest that congenitally low MAO-A activity leads to abnormal development of the cerebellum...
  14. pmc Cognitive abnormalities and hippocampal alterations in monoamine oxidase A and B knockout mice
    Chanpreet Singh
    Neuroscience Program, University of Southern California, Los Angeles, CA 90089, USA
    Proc Natl Acad Sci U S A 110:12816-21. 2013
    ..The combined deficiency of MAO A and B results in significantly elevated levels of serotonin (5-hydroxytryptamine), norepinephrine, dopamine, and β..
  15. doi Rines E3 ubiquitin ligase regulates MAO-A levels and emotional responses
    Miyuki Kabayama
    Laboratory for Behavioral and Developmental Disorders, Molecular Neuropathology Group, and Support Unit for Animal Resources Development, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    J Neurosci 33:12940-53. 2013
    ..These findings verify that Rines is a critical regulator of the monoaminergic system and emotional behavior and identify a promising candidate drug target for treating diseases associated with emotion. ..
  16. doi A functional polymorphism of the MAOA gene is associated with neural responses to induced anger control
    Thomas F Denson
    University of New South Wales
    J Cogn Neurosci 26:1418-27. 2014
    ..experimental work has linked individual differences in a functional polymorphism of the monoamine oxidase-A gene (MAOA) to anger-driven aggression...
  17. doi The mouse cortico-striatal projectome
    Houri Hintiryan
    USC Stevens Neuroimaging and Informatics Institute, Laboratory of Neuro Imaging LONI, Keck School of Medicine of University of Southern California, Los Angeles, California, USA
    Nat Neurosci 19:1100-14. 2016
    ..Together, our results provide the structural basis for studying the functional diversity of the dorsal striatum and disruptions of cortico-basal ganglia networks across a broad range of disorders. ..
  18. pmc Differential patterning of genes involved in serotonin metabolism and transport in extra-embryonic tissues of the mouse
    Hsiao Huei Wu
    Department of Pediatrics, Children s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Placenta 42:74-83. 2016
    ..As an initial step in determining the mechanisms involved, we investigated the expression patterns of genes critical for 5-HT system function in mouse extraembryonic tissues...
  19. pmc Amphetamine manipulates monoamine oxidase-A level and behavior using theranostic aptamers of transcription factors AP-1/NF-kB
    Christina H Liu
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, 02129, USA
    J Biomed Sci 23:21. 2016
    ..We applied aptamers containing a DNA binding sequence, as well as a random sequence (without target) to study the modulation of amphetamine-induced MAO levels and hyperactivity in living mice...
  20. doi Islet-specific monoamine oxidase A and B expression depends on MafA transcriptional activity and is compromised in type 2 diabetes
    Elvira Ganic
    Stem Cell Center, Lund University, Klinikgatan 26, Lund 22184, Sweden
    Biochem Biophys Res Commun 468:629-35. 2015
    ..Intracellular monoamine levels are controlled by monoamine oxidases (Mao) A and B. Here we show that MaoA and MaoB are expressed in mouse islet β cells and that inhibition of Mao activity reduces insulin secretion in ..
  21. pmc Monoamine Oxidase A is Required for Rapid Dendritic Remodeling in Response to Stress
    Sean C Godar
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA Drs Godar, Chen, and Shih and Mr Li Department of Cell and Neurobiology, University of Southern California, Los Angeles, CA Dr Shih Department of Pharmacology and Toxicology, University of Kansas, Lawrence, KS Drs Godar and Bortolato Consortium for Translational Research on Aggression and Drug Abuse ConTRADA, University of Kansas, Lawrence, KS, Drs Godar and Bortolato Department of Psychological and Brain Sciences and Program in Neuroscience, Indiana University, Bloomington, IN Ms Richards and Dr Wellman
    Int J Neuropsychopharmacol 18:. 2015
    ..Furthermore, we tested whether these processes may be affected by deficiency of monoamine oxidase A (MAO-A), the primary enzyme catalyzing monoamine metabolism...
  22. pmc Evidence revealing deregulation of the KLF11-MAO A pathway in association with chronic stress and depressive disorders
    Sharonda Harris
    Department of Psychiatry and Human Behavior, Jackson, MS, USA
    Neuropsychopharmacology 40:1373-82. 2015
    ..However, it has been reported that monoamine oxidase A (MAO A, a major neurotransmitter-degrading enzyme) is significantly increased in the brains of human subjects affected ..
  23. pmc Inhibition of Excessive Monoamine Oxidase A/B Activity Protects Against Stress-induced Neuronal Death in Huntington Disease
    Jolene Ooi
    Translational Laboratory in Genetic Medicine TLGM, Agency for Science, Technology and Research A STAR, 8A Biomedical Grove, Immunos, Level 5, Singapore, 138648, Singapore
    Mol Neurobiol 52:1850-61. 2015
    ..Altogether, this study demonstrates abnormal MAO expression and activity and suggests a potential use for MAO inhibitors in HD. ..
  24. pmc Serotonin receptor 6 mediates defective brain development in monoamine oxidase A-deficient mouse embryos
    Chi Chiu Wang
    From the Department of Obstetrics and Gynaecology
    J Biol Chem 289:8252-63. 2014
    ..In summary, our findings suggest that excessive 5-HT in MAO-A-deficient mouse embryos triggers cellular signaling cascades via 5-Htr6, which suppresses developmental apoptosis in the brain and thus induces developmental retardations. ..
  25. pmc NMDARs mediate the role of monoamine oxidase A in pathological aggression
    Marco Bortolato
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, California 90089, USA
    J Neurosci 32:8574-82. 2012
    Converging evidence shows that monoamine oxidase A (MAO A), the key enzyme catalyzing serotonin (5-hydroxytryptamine; 5-HT) and norepinephrine (NE) degradation, is a primary factor in the pathophysiology of antisocial and aggressive ..
  26. pmc SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive
    Sergiy Libert
    Paul F Glenn Laboratory, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 147:1459-72. 2011
    ..Together these data indicate that SIRT1 mediates levels of anxiety, and this regulation may be adaptive in a changing environment of food availability...
  27. pmc Social deficits and perseverative behaviors, but not overt aggression, in MAO-A hypomorphic mice
    Marco Bortolato
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Neuropsychopharmacology 36:2674-88. 2011
    ..Taken together, our findings indicate that MAO A hypomorphism results in behavioral and morphological alterations distinct from those featured by MAO-A KO mice.
  28. pmc Monoamine oxidase A regulates neural differentiation of murine embryonic stem cells
    Zhi Qiang Wang
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089 9121, USA
    J Neural Transm (Vienna) 118:997-1001. 2011
    ..In this study, wild-type (WT) and MAO A(neo) embryonic stem (ES) cell lines were established from the inner cell mass of murine blastocysts and their ..
  29. doi Alzheimer disease-related presenilin-1 variants exert distinct effects on monoamine oxidase-A activity in vitro
    Paul R Pennington
    Cell Signalling Laboratory, Department of Psychiatry, University of Saskatchewan, B45 HSB, 107 Wiggins Rd, Saskatoon, SK, S7N 5E5, Canada
    J Neural Transm (Vienna) 118:987-95. 2011
    ..The ability to induce MAO-A catalytic activity with a PS-1/γ-secretase inhibitor should also be considered when designing secretase inhibitor-based therapeutics...
  30. pmc Maladaptive defensive behaviours in monoamine oxidase A-deficient mice
    Sean C Godar
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
    Int J Neuropsychopharmacol 14:1195-207. 2011
    ..Although MAOA deficiency is associated with reactive aggression in humans and mice, the involvement of this enzyme in defensive ..
  31. doi Monoamine oxidases are mediators of endothelial dysfunction in the mouse aorta
    Adrian Sturza
    Institut für Kardiovaskuläre Physiologie, Goethe Universitat, Frankfurt, Germany
    Hypertension 62:140-6. 2013
    ..Thus, MAO-A and MAO-B are both expressed in the mouse aorta, induced by in vivo lipopolysaccharide and angiotensin II treatment and contribute via the generation of H(2)O(2) to endothelial dysfunction in vascular disease models...
  32. ncbi MAO-A and -B gene knock-out mice exhibit distinctly different behavior
    J C Shih
    Department of Molecular Pharmacology and Toxicology, University of Southern California, School of Pharmacy, Los Angeles 90033, USA
    Neurobiology (Bp) 7:235-46. 1999
    ..MAO KO mice are valuable models for investigating the role of monoamines in aggression and neurodegenerative and stress-related disorders...
  33. doi Serotonin immunoreactivity in auditory brainstem neurons of the postnatal monoamine oxidase-A knockout mouse
    Ann M Thompson
    The University of Oklahoma Health Sciences Center, Department of Otorhinolaryngology, Oklahoma City, OK 73126 0901, USA
    Brain Res 1228:58-67. 2008
    ..The pattern of expression indicates that 5-HT has a developmental role in select populations of neurons of the ascending auditory pathway prior to any influences of sound-evoked activity...
  34. doi Experimental evidence that the serotonin transporter mediates serotonin accumulation in LSO neurons of the postnatal mouse
    Ann M Thompson
    The University of Oklahoma Health Sciences Center, Department of Otorhinolaryngology, Oklahoma City, OK 73126 0901, USA
    Brain Res 1253:60-8. 2009
    ..These results indicate that LSO neurons express the functional 5-HT transporter to internalize 5-HT; this mechanism may serve to regulate extracellular 5-HT levels during maturation of their terminal endings in the inferior colliculus...
  35. doi Regional changes in the cholinergic system in mice lacking monoamine oxidase A
    Regis Grailhe
    Institut Pasteur URA CNRS D 2182, 28 rue du Docteur Roux, 75015 Paris, France
    Brain Res Bull 78:283-9. 2009
    Elevated brain monoamine concentrations resulting from monoamine oxidase A genetic ablation (MAOA knock-out mice) lead to changes in other neurotransmitter systems...
  36. pmc Monoamine oxidase A-mediated enhanced catabolism of norepinephrine contributes to adverse remodeling and pump failure in hearts with pressure overload
    Nina Kaludercic
    Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    Circ Res 106:193-202. 2010
    ..Because excess reactive oxygen species and catecholamines are major contributors to the pathophysiology of congestive heart failure, MAOs could play an important role in this process...
  37. doi Immobility and hyperthermia in the tail suspension test: association with the Porsolt test and the reflex startle reaction in 11 inbred mouse strains and the effects of genetic knockout of MAO A
    N K Popova
    Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia
    Neurosci Behav Physiol 40:489-94. 2010
    ..startle reaction were assessed in mice of 11 inbred strains and in Tg8 mice, which have genetic knockout of MAO A. Sharp genotypic differences in immobility were seen, while there was no correlation with the hyperthermic ..
  38. pmc Monoamine oxidases regulate telencephalic neural progenitors in late embryonic and early postnatal development
    Aiwu Cheng
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA
    J Neurosci 30:10752-62. 2010
    ..Here we show that mice lacking the monoamine metabolic enzymes MAO A and MAO B (MAO AB-deficient mice) exhibit diminished proliferation of neural stem cells (NSC) in the developing ..
  39. pmc Regional cerebral cortical activation in monoamine oxidase A-deficient mice: differential effects of chronic versus acute elevations in serotonin and norepinephrine
    D P Holschneider
    Department of Psychiatry and the Behavioral Sciences, LAC USC School of Medicine, 1200 North State St, CA 90033, Los Angeles, USA
    Neuroscience 101:869-77. 2000
    ..Such a differential response may reflect neurodevelopmental abnormalities and/or effects of a chronic physiological adaptation on the regulation of cortical activation...
  40. ncbi Differences in somatosensory processing in S1 barrel cortex between normal and monoamine oxidase A knockout (Tg8) adult mice
    Z Yang
    Neuroscience Section, Biomedical Sciences Division, St Bartholomews and the Royal London School of Medicine, Queen Mary and Westfield College, London University, Mile End Road, London E1 4NS, UK
    Cereb Cortex 11:26-36. 2001
    ..These findings suggest that factors other than barrels and clustering of thalamo-cortical terminals define receptive field geometry...
  41. pmc A transient placental source of serotonin for the fetal forebrain
    Alexandre Bonnin
    Zilkha Neurogenetic Institute, Keck School of Medicine of USC, Los Angeles, California 90089, USA
    Nature 472:347-50. 2011
    ....
  42. ncbi Abnormal phrenic motoneuron activity and morphology in neonatal monoamine oxidase A-deficient transgenic mice: possible role of a serotonin excess
    C Bou-Flores
    Unité Propre de Recherche UPR 9011, Development and Pathology of Movement, Paris, France
    J Neurosci 20:4646-56. 2000
    ..Disorders affecting 5-HT metabolism during gestation may therefore have deleterious effects on newborns...
  43. pmc Monoamine oxidase a expression is vital for embryonic brain development by modulating developmental apoptosis
    Chi Chiu Wang
    Institute of Biochemistry, University Medicine Berlin Charite, Oudenarder Strasse 16, 13347 Berlin, Germany
    J Biol Chem 286:28322-30. 2011
    ..Moreover, we observed reduced cyclin D1 levels as an indicator of impaired cell proliferation in MAO-A knockdown embryos. This data highlights MAO-A as a vital regulator of embryonic brain development...
  44. ncbi Locomotor network maturation is transiently delayed in the MAOA-deficient mouse
    J R Cazalets
    Centre National de la Recherche Scientifique, Laboratoire de Neurobiologie et Mouvements, 13402 Marseille Cedex 9, France
    J Neurophysiol 83:2468-70. 2000
    In vivo and in vitro experiments were performed in control (C3H) and monoamine oxidase A (MAOA)-deficient (Tg8) neonatal mice to determine whether MAOA deficiency affected spinal locomotor network maturation...
  45. pmc Altered expression of tyrosine hydroxylase in the locus coeruleus noradrenergic system in citalopram neonatally exposed rats and monoamine oxidase a knock out mice
    Junlin Zhang
    Department of Anatomy, University of Mississippi Medical Center, Jackson, USA
    Anat Rec (Hoboken) 294:1685-97. 2011
    ..of them appeared to be hypertrophic; (2) slightly enhanced NE cortical TH immunoreactive fibers were also noted in MAO A KO mice, and many of them revealed varicosities compared with the rather smooth NE cortical TH immunoreactive ..
  46. ncbi Excess of serotonin (5-HT) alters the segregation of ispilateral and contralateral retinal projections in monoamine oxidase A knock-out mice: possible role of 5-HT uptake in retinal ganglion cells during development
    A L Upton
    Institut National de la Santé et de la Recherche Médicale U106, Hopital de la Salpetriere, 75651 Paris Cedex 13, France
    J Neurosci 19:7007-24. 1999
    ..We report that this segregation does not occur in monoamine oxidase A knock-out mice (MAOA-KO) that have elevated brain levels of serotonin (5-HT) and noradrenaline...
  47. ncbi Serotonin levels are abnormally elevated in the fetus of the monoamine oxidase-A-deficient transgenic mouse
    A M Lajard
    UPRESA CNRS 6034, Fac St Jérôme, Marseille, France
    Neurosci Lett 261:41-4. 1999
    ....
  48. pmc Profound neuronal plasticity in response to inactivation of the dopamine transporter
    S R Jones
    Howard Hughes Medical Institute Laboratories, Department of Cell Biology and Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 95:4029-34. 1998
    ....
  49. pmc Selective enhancement of emotional, but not motor, learning in monoamine oxidase A-deficient mice
    J J Kim
    Neuroscience Program, University of Southern California, Los Angeles, CA 90089 2520, USA
    Proc Natl Acad Sci U S A 94:5929-33. 1997
    Mice deficient in monoamine oxidase A (MAOA), an enzyme that metabolizes monoamines such as norepinephrine and serotonin, have elevated norepinephrine and serotonin levels in the frontal cortex, hippocampus, and cerebellum, compared with ..
  50. ncbi Characterization and mapping of the mouse NDP (Norrie disease) locus (Ndp)
    E M Battinelli
    Molecular Neurogenetics Laboratory, Massachusetts General Hospital, East, Charlestown 02129, USA
    Mamm Genome 7:93-7. 1996
    ..Pedigree analysis of an interspecific mouse backcross localizes the mouse NDP gene close to Maoa in the conserved segment, which runs from CYBB to PFC in both human and mouse.
  51. ncbi Lack of barrels in the somatosensory cortex of monoamine oxidase A-deficient mice: role of a serotonin excess during the critical period
    O Cases
    Centre National de la Recherche Scientifique, Institut Curie, Orsay France
    Neuron 16:297-307. 1996
    In a transgenic mouse line (Tg8) deficient for the gene encoding monoamine oxidase A (MAOA), we show that the primary somatosensory cortex (S1) lacks the characteristic barrel-like clustering of layer IV neurons, whereas normal pattern ..
  52. ncbi Novel sequences conserved on the human and mouse X chromosomes
    S H Laval
    Genetics Division, MRC Radiobiology Unit, Chilton, Didcot, Oxon, United Kingdom
    Genomics 15:483-91. 1993
    ..The mapping of another probe that detects a novel sequence family (DXF34) close to the X chromosome centromere in both species suggests that a block of pericentromeric material is conserved between the X chromosomes of man and mouse...
  53. ncbi Partial inversion of gene order within a homologous segment on the X chromosome
    S H Laval
    Genetics Division, Medical Research Council Radiobiology Unit, Didcot, Oxon, UK
    Mamm Genome 4:119-23. 1993
    ..Furthermore, they indicate that the mouse mutant scurfy and the human genetic disorder Wiskott-Aldrich syndrome, which have been mapped to the same regions as GATA1/Gf-1 in both species, may indeed be homologous disorders...
  54. ncbi Activities of monoamine oxidase-A and -B are altered in the brains of congenitally hyperammonemic sparse-fur (spf) mice
    V L Rao
    Neuroscience Research Unit, André Viallet Clinical Research Center University of Montreal, Hopital Saint Luc, Que, Canada
    Neurosci Lett 170:27-30. 1994
    Activities of monoamine oxidases, MAOA and MAOB, were measured using radiometric assays in different brain regions of the sparse-fur (spf/Y) mouse, a model of congenital hyperammonemia resulting from an X-chromosomal defect of ornithine ..
  55. ncbi Differential age-related changes of MAO-A and MAO-B in mouse brain and peripheral organs
    J Saura
    Biochemistry Unit, Faculty of Medicine, University of Barcelona, Spain
    Neurobiol Aging 15:399-408. 1994
    ..Also of interest is the decrease of liver MAO-B in old animals, which, together with the increase of MAO-B in the brain, might underlie the high sensitivity of old BL/C57 mice to MPTP...
  56. pmc Localization of monoamine oxidase A and B genes on the mouse X chromosome
    J M Derry
    MRC Molecular Neurobiology Unit, Medical Research Council Centre, Cambridge, UK
    Nucleic Acids Res 17:8403. 1989
  57. ncbi The construction of human somatic cell hybrids containing portions of the mouse X chromosome and their use to generate DNA probes via interspersed repetitive sequence polymerase chain reaction
    G E Herman
    Institute for Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030
    Genomics 10:961-70. 1991
    ..1/1. These results demonstrate the feasibility of this method as applied to the mouse genome and the high likelihood of generating useful DNA probes from a targeted region...
  58. ncbi The properdin structural locus (Pfc) lies close to the locus for tissue inhibitor of metallothionine proteases (Timp) on the mouse X chromosome
    S H Laval
    MRC Radiobiology Unit, Didcot, Oxon, United Kingdom
    Genomics 10:1030-4. 1991
    ..By minimizing the number of double recombinants the following gene order was obtained: Otc-Mao-a-(Pfc, Timp)-Hprt-Cf-9. The implications for comparative mapping of human and mouse X chromosomes are discussed...
  59. ncbi Effects of genetic depletion of monoamines on somatosensory cortical development
    C Alvarez
    INSERM U106, IFR des Neurosciences, Bâtiment de Pédiatrie, Hopital de la Pitie Salpetriere, 47 Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Neuroscience 115:753-64. 2002
    ..Mice lacking both VMAT2 and monoamine oxidase type A (MAOA) were generated. VMAT2-MAOA DKO mice are hypomorphic but survive until P13...
  60. ncbi MAO A knockout attenuates adrenocortical response to various kinds of stress
    Nina K Popova
    Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Pr Lavrentieva 10, Novosibirsk 630090, Russia
    Psychoneuroendocrinology 31:179-86. 2006
    The effect of a lack of the gene encoding monoamine oxidase A (MAO A) in transgenic Tg 8 mice on the corticosterone response to restraint, cold, water deprivation-induced, or social acute stress as well as chronic variable stress was ..
  61. doi Regulation of monoamine oxidase A by circadian-clock components implies clock influence on mood
    Gabriele Hampp
    Department of Medicine, Division of Biochemistry, University of Fribourg, Fribourg, Switzerland
    Curr Biol 18:678-83. 2008
    ..We find that transcription of the monoamine oxidase A (Maoa) promoter is regulated by the clock components BMAL1, NPAS2, and PER2...
  62. pmc A spontaneous point mutation produces monoamine oxidase A/B knock-out mice with greatly elevated monoamines and anxiety-like behavior
    Kevin Chen
    Department of Molecular Pharmacology and Toxicology, University of Southern California School of Pharmacy, Los Angeles, California 90089 9121, USA
    J Biol Chem 279:39645-52. 2004
    A spontaneous monoamine oxidase A (MAO A) mutation (A863T) in exon 8 introduced a premature stop codon, which produced MAO A/B double knock-out (KO) mice in a MAO B KO mouse colony...
  63. ncbi The use of adolescent nonhuman primates to model human alcohol intake: neurobiological, genetic, and psychological variables
    Christina S Barr
    V Research Fellow, NIH Animal Center, Building 112, P O Box 529, Poolesville, MD 20837 0529, USA
    Ann N Y Acad Sci 1021:221-33. 2004
    ..genes, for example, a repeat polymorphism in the transcriptional control region of the monoamine oxidase gene (MAOA-LPR), increases the propensity for adolescent males to consume alcohol...
  64. ncbi Altered zincergic innervation of the developing primary somatosensory cortex in monoamine oxidase-A knockout mice
    Craig E Brown
    Department of Psychology, University of Calgary, 2500 University Drive, NW, Calgary, Alberta T2N 1N4, Canada
    Brain Res Dev Brain Res 142:19-29. 2003
    ....
  65. ncbi Effect of monoamine oxidase A knockout on resistance to long-term exposure to ethanol
    E A Ivanova
    Laboratory of Phenogenetics of Behavior, Institute of Cytology and Genetics, Siberian Department of the Russian Academy of Sciences, Novosibirsk
    Bull Exp Biol Med 133:603-5. 2002
    It was shown that transgenic Tg8 mice with monoamine oxidase A (MAO A) gene knockout demonstrate higher resistance to acute ethanol exposure compared to wild type C3H mice. This difference was observed at the early age (28-30 days)...
  66. ncbi Dissociating barrel development and lesion-induced plasticity in the mouse somatosensory cortex
    Alexandra Rebsam
    Institut National de la Santé et de la Recherche Médicale U616, Université Paris VI Hôpital Salpêtrière, 75651 Paris Cedex 13, France
    J Neurosci 25:706-10. 2005
    ..To test whether TCA development and lesion-induced plasticity are linked, we used monoamine oxidase A knock-out (MAOA-KO) mice in which normal TCA development is halted by an excess of serotonin...
  67. ncbi Adult experience-dependent plasticity of S1 barrel cortex in the normal and monoamine oxidase-A knockout (Tg8) mouse
    Zhuo Yang
    Division of Medical Sciences Physiology, The Medical School, University of Birmingham, Birmingham B15 2TT, UK
    Cereb Cortex 12:1269-79. 2002
    ..Although differing from NOR mice, experiential plasticity was not strongly compromised in Tg8 mice. Differences in WP plasticity from rat barrel cortex are discussed...
  68. ncbi Refinement of thalamocortical arbors and emergence of barrel domains in the primary somatosensory cortex: a study of normal and monoamine oxidase a knock-out mice
    Alexandra Rebsam
    Institut National de la Santé et de la Recherche Médicale U106, Hopital Pitie Salpetriere, 75013 Paris, France
    J Neurosci 22:8541-52. 2002
    ..emerges, we analyzed TCA development in mice that do not form barrels, the monoamine oxidase A knock-out (MAOA-KO), and in MAOA/5-HT(1B) receptor double-KO mice, which have a restored barrel field...
  69. ncbi Interactions between TrkB signaling and serotonin excess in the developing murine somatosensory cortex: a role in tangential and radial organization of thalamocortical axons
    Tania Vitalis
    Department of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 22:4987-5000. 2002
    Mice lacking monoamine oxidase A (MAOA) display high levels of brain serotonin during the first postnatal week, causing an exuberant outgrowth of thalamocortical axons (TCAs) in layer IV of the somatosensory cortex (S1)...
  70. ncbi Altered presynaptic function in monoaminergic neurons of monoamine oxidase-A knockout mice
    Catarina A Owesson
    Neurotransmission Laboratory, Academic Department of Anaesthesia and Intensive Care, Barts and the London School of Medicine and Dentistry, Alexandra Wing, Royal London Hospital, Whitechapel, London E1 1BB, UK
    Eur J Neurosci 15:1516-22. 2002
    ..In summary, MAO-A KO mice show major dysregulation of monoaminergic presynaptic mechanisms such as autoreceptor control and transporter kinetics...
  71. ncbi Altered regulation of the 5-HT system in the brain of MAO-A knock-out mice
    A Evrard
    INSERM U288, NeuroPsychoPharmacologie Moléculaire, Cellulaire et Fonctionnelle, Faculté de Médecine Pitié Salpêtrière, 91 Boulevard de l Hopital, 75634 Paris Cedex 13, France
    Eur J Neurosci 15:841-51. 2002
    ....
  72. ncbi Increased baroreceptor response in mice deficient in monoamine oxidase A and B
    D P Holschneider
    Department of Psychiatry and the Behavioral Sciences, Keck School of Medicine, LAC USC Hosp, University of Southern California Los Angeles 90024, USA
    Am J Physiol Heart Circ Physiol 282:H964-72. 2002
    ..These data suggest that prevention of hypertension may occur in chronic states of catecholaminergic/indoleaminergic excess by increased gain of the baroreflex...
  73. ncbi Developmental expression of monoamine oxidases A and B in the central and peripheral nervous systems of the mouse
    Tania Vitalis
    Department of Biomedical Sciences, Edinburgh EH8 9XD, Scotland, United Kingdom
    J Comp Neurol 442:331-47. 2002
    Monoamine oxidases A (MAOA) and B (MAOB) are key players in the inactivation pathway of biogenic amines...
  74. ncbi Altered respiratory activity and respiratory regulations in adult monoamine oxidase A-deficient mice
    H Burnet
    Centre National de la Recherche Scientifique Développement et Pathologie du Mouvement, Biologie des Rythmes et du Développement, 13402 Marseille Cedex 20, France
    J Neurosci 21:5212-21. 2001
    ..In conclusion, the metabolism of serotonin plays a crucial role in the maturation of the respiratory network and in both the respiratory activity and the respiratory regulations...
  75. ncbi Altered behavior and alcohol tolerance in transgenic mice lacking MAO A: a comparison with effects of MAO A inhibitor clorgyline
    N K Popova
    Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Lavrentieva 10, 630090 Novosibirsk 90, Russia
    Pharmacol Biochem Behav 67:719-27. 2000
    The influence of deficiency of monoamine oxidase A (MAO A) gene and the lack of enzyme MAO A on the behavior of transgenic mouse strain (Tg8) was studied...
  76. ncbi The extraneuronal monoamine transporter Slc22a3/Orct3 co-localizes with the Maoa metabolizing enzyme in mouse placenta
    S Verhaagh
    Department of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    Mech Dev 100:127-30. 2001
    ..The results show that Orct3 expression overlaps that of the monoamine metabolizing enzyme Maoa in the labyrinth layer of the placenta with an expression pattern distinct from that of the neuronal transporters ..
  77. pmc Lipidomic analysis and electron transport chain activities in C57BL/6J mouse brain mitochondria
    Michael A Kiebish
    Biology Department, Boston College, Chestnut Hill, Massachusetts 02467, USA
    J Neurochem 106:299-312. 2008
    ..NS and Syn mitochondrial lipidomic heterogeneity could influence energy metabolism, which may contribute to metabolic compartmentation of the brain...
  78. ncbi Effect of MAO A deficiency on different kinds of aggression and social investigation in mice
    Galina B Vishnivetskaya
    Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia
    Aggress Behav 33:1-6. 2007
    Monoamine oxidase A (MAO A) degrades serotonin, dopamine and noradrenaline, factors critically involved in the regulation of aggression...
  79. ncbi Developmental cell death is enhanced in the cerebral cortex of mice lacking the brain vesicular monoamine transporter
    Lea Stankovski
    Institut National de la Sante et de la Recherche Medicale, Unité 616, Institut Fédératif de Recherche Neurosciences, Hopital de la Pitie Salpetriere, 75651 Paris, France
    J Neurosci 27:1315-24. 2007
    ..However, when monoamine oxidase type A was invalidated in the VMAT2 KO background (VMAT2-MAOA DKO mice), increases in 5-HT levels coincided with ..
  80. ncbi Excessive activation of serotonin (5-HT) 1B receptors disrupts the formation of sensory maps in monoamine oxidase a and 5-ht transporter knock-out mice
    N Salichon
    Centre National de la Recherche Scientifique, Unité Mixte de Recherche 146, Institut Curie, 91405 Orsay, France
    J Neurosci 21:884-96. 2001
    Deficiency in the monoamine degradation enzyme monoamine oxidase A (MAOA) or prenatal exposure to the monoamine uptake inhibitor cocaine alters behavior in humans and rodents, but the mechanisms are unclear...
  81. pmc Forebrain-specific expression of monoamine oxidase A reduces neurotransmitter levels, restores the brain structure, and rescues aggressive behavior in monoamine oxidase A-deficient mice
    Kevin Chen
    Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 282:115-23. 2007
    ..Forebrain-specific MAO A transgenic mice were generated from MAO A knock-out (KO) mice by using the promoter of calcium-dependent kinase ..
  82. ncbi Monoamine oxidase A knockout mice exhibit impaired nicotine preference but normal responses to novel stimuli
    Soh Agatsuma
    Laboratory of Molecular Psychobiology, Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Hum Mol Genet 15:2721-31. 2006
    ..We examined the impact of constitutive monoamine oxidase A (MAOA) deficiency in mice on nicotine reward and responses to novel stimuli...
  83. pmc Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway
    Xiao Ming Ou
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA
    Proc Natl Acad Sci U S A 103:10923-8. 2006
    Monoamine oxidase A (MAO A) degrades serotonin, norepinephrine, and dopamine and produces reactive oxygen that may cause neuronal cell death...
  84. ncbi Aberrant accumulation of serotonin in dopaminergic neurons
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    Neurosci Lett 401:49-54. 2006
    ..we have generated double knockout mice lacking both the 5-HTT and the catabolizing enzyme monoamine oxidase A (MAOA). We found aberrant 5-HT accumulation in the striatum of these MAOA/5-HTT double knockout mice...
  85. ncbi Effect of monoamine oxidease A knockout on the expression of 5-HTlA receptors
    V S Naumenko
    Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, pr Lavrent eva 10, Novosibirsk, 630060 Russia
    Dokl Biol Sci 402:205-7. 2005
  86. ncbi Developmental expression pattern of monoamine oxidases in sensory organs and neural crest derivatives
    Tania Vitalis
    Department of Anatomy and Developmental Biology, University College London, WC1E6BT London, United Kingdom
    J Comp Neurol 464:392-403. 2003
    ..In contrast, MAOA expression was restricted to the sympathetic ganglia and to the meningeal and capillary blood vessels...
  87. doi Genetic deletion of MAO-A promotes serotonin-dependent ventricular hypertrophy by pressure overload
    Olivier Lairez
    INSERM, U858, Toulouse, France
    J Mol Cell Cardiol 46:587-95. 2009
    ..These results show for the first time that regulation of peripheral 5-HT by MAO-A plays a role in ventricular remodeling via activation of 5-HT(2A) receptors...
  88. ncbi Positioning of five genes (CASK, ARX, SAT, IMAGE cDNAs 248928 and 253949) from the human X chromosome short arm with respect to evolutionary breakpoints on the mouse X chromosome
    H J Blair
    MRC Mammalian Genetics Unit, Harwell, Oxon OX11 0RD, UK
    Mamm Genome 11:710-2. 2000
  89. doi Prenatal activation of 5-HT2A receptor induces expression of 5-HT1B receptor in phrenic motoneurons and alters the organization of their premotor network in newborn mice
    Helene Bras
    Laboratoire Plasticité et Physio Pathologie de la Motricité, UMR 6196 CNRS, Universite de la Mediterranee, Marseille, France
    Eur J Neurosci 28:1097-107. 2008
    ..These results show that a prenatal 5-HT excess affects, via the overactivation of 5-HT(2A)-R, the expression of 5-HT(1B)-R in PhMns and the organization of their premotor network...
  90. pmc Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA
    O Cases
    Centre National de la Recherche Scientifique CNRS, Unité de Recherche Associée URA, Institut Curie, Orsay, France
    Science 268:1763-6. 1995
    Deficiency in monoamine oxidase A (MAOA), an enzyme that degrades serotonin and norepinephrine, has recently been shown to be associated with aggressive behavior in men of a Dutch family...
  91. doi DCC is required for the tangential migration of noradrenergic neurons in locus coeruleus of mouse brain
    Ming Shi
    Institute of Neuroscience and State Key Laboratory of Neuroscience, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    Mol Cell Neurosci 39:529-38. 2008
    ..Thus, our findings demonstrate that DCC is a key regulator of tangential migration of LC neurons during the embryonic development...
  92. pmc Monoamine oxidase: from genes to behavior
    J C Shih
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles 90033, USA
    Annu Rev Neurosci 22:197-217. 1999
    ..b>MAO A and B genes are located on the X-chromosome (Xp11...
  93. doi Gap junction-mediated astrocytic networks in the mouse barrel cortex
    Vanessa Houades
    INSERM, U840, 75005 Paris, France
    J Neurosci 28:5207-17. 2008
    ..Such properties confine intercellular communication in astrocytes within a defined barrel as previously reported for excitatory neuronal circuits...