Mafb

Summary

Gene Symbol: Mafb
Description: v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)
Alias: Kreisler, Krml, Krml1, transcription factor MafB, Kreisler (maf-related) leucine zipper protein, V-maf musculoaponeurotic fibrosarcoma oncogene homolog B, maf-B, segmentation protein Kr, transcription factor Maf-1
Species: mouse

Top Publications

  1. pmc MafB is required for islet beta cell maturation
    Isabella Artner
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, 723 Light Hall, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 104:3853-8. 2007
  2. doi Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
    Katrin Kierdorf
    Department of Neuropathology, University of Freiburg, Freiburg, Germany
    Nat Neurosci 16:273-80. 2013
  3. ncbi Mouse MafA, homologue of zebrafish somite Maf 1, contributes to the specific transcriptional activity through the insulin promoter
    Miwako Kajihara
    Department of Internal Medicine, University of Tsukuba, 1 1 1, Tennodai, Tsukuba 305 8575, Japan
    Biochem Biophys Res Commun 312:831-42. 2003
  4. pmc Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas
    Aiping Du
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 58:2059-69. 2009
  5. ncbi The kreisler mouse: a hindbrain segmentation mutant that lacks two rhombomeres
    I J McKay
    Department of Zoology, Oxford University, UK
    Development 120:2199-211. 1994
  6. ncbi The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor
    S P Cordes
    Department of Pediatrics, Stanford University, California 94305
    Cell 79:1025-34. 1994
  7. ncbi Altered rhombomere-specific gene expression and hyoid bone differentiation in the mouse segmentation mutant, kreisler (kr)
    M A Frohman
    Department of Anatomy, School of Medicine, University of California, San Francisco 94143
    Development 117:925-36. 1993
  8. ncbi The role of kreisler in segmentation during hindbrain development
    M Manzanares
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, United Kingdom
    Dev Biol 211:220-37. 1999
  9. ncbi Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development
    M Rossel
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    Development 126:5027-40. 1999
  10. ncbi Molecular cloning and functional characterization of the mouse mafB gene
    K Huang
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo, Japan
    Gene 242:419-26. 2000

Scientific Experts

Detail Information

Publications106 found, 100 shown here

  1. pmc MafB is required for islet beta cell maturation
    Isabella Artner
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, 723 Light Hall, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 104:3853-8. 2007
    ..Islet cell development was examined in mice lacking MafB, a transcription factor expressed in immature alpha (glucagon(+)) and beta (insulin(+)) cells and capable of ..
  2. doi Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
    Katrin Kierdorf
    Department of Neuropathology, University of Freiburg, Freiburg, Germany
    Nat Neurosci 16:273-80. 2013
    ..Our data provide cellular and molecular insights into the origin and development of microglia...
  3. ncbi Mouse MafA, homologue of zebrafish somite Maf 1, contributes to the specific transcriptional activity through the insulin promoter
    Miwako Kajihara
    Department of Internal Medicine, University of Tsukuba, 1 1 1, Tennodai, Tsukuba 305 8575, Japan
    Biochem Biophys Res Commun 312:831-42. 2003
    ..These results indicate that MafA is the homologue of zebrafish SMaf1 and acts as a transcriptional activator of the insulin gene promoter through the RIPE3b element...
  4. pmc Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas
    Aiping Du
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 58:2059-69. 2009
    ....
  5. ncbi The kreisler mouse: a hindbrain segmentation mutant that lacks two rhombomeres
    I J McKay
    Department of Zoology, Oxford University, UK
    Development 120:2199-211. 1994
    b>kreisler is a recessive mutation resulting in gross malformation of the inner ear of homozygous mice. The defects in the inner ear are related to abnormalities in the hindbrain of the embryo, adjacent to the ear rudiments. At E9...
  6. ncbi The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor
    S P Cordes
    Department of Pediatrics, Stanford University, California 94305
    Cell 79:1025-34. 1994
    The mouse kreisler (kr) mutation causes segmentation abnormalities in the caudal hindbrain and defective inner ear development...
  7. ncbi Altered rhombomere-specific gene expression and hyoid bone differentiation in the mouse segmentation mutant, kreisler (kr)
    M A Frohman
    Department of Anatomy, School of Medicine, University of California, San Francisco 94143
    Development 117:925-36. 1993
    ..by in situ hybridization, the expression of five rhombomere-specific genes in mouse embryos homozygous for the kreisler (kr) mutation, in which rhombomeres 4-7 are replaced by a smooth morphologically unsegmented neural tube...
  8. ncbi The role of kreisler in segmentation during hindbrain development
    M Manzanares
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, United Kingdom
    Dev Biol 211:220-37. 1999
    The mouse kreisler gene is expressed in rhombomeres (r) 5 and 6 during neural development and kreisler mutants have patterning defects in the hindbrain that are not fully understood...
  9. ncbi Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development
    M Rossel
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    Development 126:5027-40. 1999
    ....
  10. ncbi Molecular cloning and functional characterization of the mouse mafB gene
    K Huang
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo, Japan
    Gene 242:419-26. 2000
    ..To clarify the molecular mechanisms controlling mafB expression, a genomic clone of the mouse mafB gene was isolated and analyzed...
  11. ncbi Hindbrain patterning: Krox20 couples segmentation and specification of regional identity
    O Voiculescu
    Laboratoire de Biologie Moléculaire du Développement, INSERM U368, Ecole Normale Superieure, 46 rue d Ulm, 75230 Paris Cedex 05, France
    Development 128:4967-78. 2001
    ....
  12. ncbi Requirement for downregulation of kreisler during late patterning of the hindbrain
    Thomas Theil
    Division of Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Development 129:1477-85. 2002
    ..A cascade of transcriptional activators, including the bZIP transcription factor encoded by the kreisler gene controls this segmentation process...
  13. ncbi The mouse Kreisler (Krml1/MafB) segmentation gene is required for differentiation of glomerular visceral epithelial cells
    Virginia Sadl
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, University of Toronto, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada
    Dev Biol 249:16-29. 2002
    ..bZip) transcription factors of the Maf subfamily have been implicated in cellular differentiation processes, Kreisler (Krml1/MafB), the gene affected in the mouse kreisler (kr) mutation, is known for its role in hindbrain ..
  14. ncbi Novel activities of Mafb underlie its dual role in hindbrain segmentation and regional specification
    Francois Giudicelli
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, 46 rue d Ulm, 75230, Paris Cedex 05, France
    Dev Biol 253:150-62. 2003
    The bZip transcription factor Mafb is expressed in two segments of the developing vertebrate hindbrain: the rhombomeres 5 and 6...
  15. ncbi Analysis of hindbrain patterning defects caused by the kreisler(enu) mutation reveals multiple roles of Kreisler in hindbrain segmentation
    Virginia S Sadl
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario, Canada
    Dev Dyn 227:134-42. 2003
    The embryonic hindbrain is subdivided into eight subunits, termed rhombomeres (r1-r8). The Kreisler (Krml1/MafB/val) transcription factor is expressed in and essential for patterning rhombomeres 5 and 6...
  16. pmc Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells
    Taka Aki Matsuoka
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Mol Cell Biol 23:6049-62. 2003
    ..that mouse islets express not only MafA but also other members of the large Maf family, specifically c-Maf and MafB. Furthermore, immunohistochemical studies revealed that at least MafA and MafB were present within the nuclei of ..
  17. ncbi MafB deficiency causes defective respiratory rhythmogenesis and fatal central apnea at birth
    Bruno Blanchi
    Centre d immunologie de Marseille Luminy, CNRS INSERM Université Mediterrané, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Nat Neurosci 6:1091-100. 2003
    ..Here we show that mice deficient for the transcription factor MafB die from central apnea at birth and are defective for respiratory rhythmogenesis in vitro...
  18. ncbi Molecular mechanisms underlying inner ear patterning defects in kreisler mutants
    Daniel Choo
    Department of Otolaryngology Head and Neck Surgery, Center for Hearing and Deafness Research, University of Cincinnati College of Medicine, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, OH 45229 3039, USA
    Dev Biol 289:308-17. 2006
    Prior studies have shown that kreisler mutants display early inner ear defects that are related to abnormal hindbrain development and signaling. These defects in kreisler mice have been linked to mutation of the kr/mafB gene...
  19. ncbi MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells
    Isabella Artner
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Diabetes 55:297-304. 2006
    ..Here, we demonstrate that within the adult pancreas, MafB is only expressed in islet alpha-cells and contributes to cell type-specific expression of the glucagon gene ..
  20. pmc A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells
    Wataru Nishimura
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, MA 02215, USA
    Dev Biol 293:526-39. 2006
    ..Ectopically expressed large-Maf factors, MafA, MafB, or cMaf, induced expression from insulin and glucagon reporter constructs, demonstrating a redundancy in their ..
  21. pmc Development of macrophages with altered actin organization in the absence of MafB
    Athar Aziz
    Centre d immunologie de Marseille Luminy, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Mol Cell Biol 26:6808-18. 2006
    In the hematopoietic system the bZip transcription factor MafB is selectively expressed at high levels in monocytes and macrophages and promotes macrophage differentiation in myeloid progenitors, whereas a dominant-negative allele can ..
  22. ncbi Enhanced expression of MafB inhibits macrophage apoptosis induced by cigarette smoke exposure
    Jun Ichi Machiya
    Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Am J Respir Cell Mol Biol 36:418-26. 2007
    ..Among the transcriptional factors investigated, only MafB was upregulated in AMs from CS-exposed mice...
  23. ncbi MafB negatively regulates RANKL-mediated osteoclast differentiation
    Kabsun Kim
    Research Institute of Medical Sciences and Medical Research Center for Gene Regulation, Chonnam National University Medical School, Hak Dong 5, Dong Ku, Gwangju 501 746, Korea
    Blood 109:3253-9. 2007
    ..Here, we show that MafB negatively regulates RANKL-induced osteoclast differentiation...
  24. pmc SOX9 is required for maintenance of the pancreatic progenitor cell pool
    Philip A Seymour
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697 2300, USA
    Proc Natl Acad Sci U S A 104:1865-70. 2007
    ..These findings will be of major significance for the development of in vitro protocols for cell replacement therapies...
  25. pmc SUMO modification regulates MafB-driven macrophage differentiation by enabling Myb-dependent transcriptional repression
    Silke Tillmanns
    Centre d Immunologie de Marseille Luminy CIML, Universite de la Mediterranee, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Mol Cell Biol 27:5554-64. 2007
    ..Thus, the myeloid transcription factor MafB promotes macrophage differentiation of myeloid progenitors, but a constitutively active Myb ..
  26. pmc Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse
    Sui Wang
    Program in Developmental Biology, Department of Cell and Developmental Biology, Vanderbilt University Medical Center, 465 21st Avenue South, Room 4128, Nashville, TN 37232, USA
    Mech Dev 124:898-910. 2007
    ..The consequences of Myt1 inactivation in the developing pancreas could be masked by activation of its paralogs, Myt1l and Myt3. These findings suggest Myt1 is involved in proper endocrine differentiation and function...
  27. pmc Math5 expression and function in the central auditory system
    Sara M Saul
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Mol Cell Neurosci 37:153-69. 2008
    ..These cells co-express MafB and are post-mitotic...
  28. pmc Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice
    Wataru Nishimura
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, USA
    Dev Biol 314:443-56. 2008
    During pancreatic development insulin(+) cells co-express the transcription factors MafB and Pax6, and transition from a MafA(-) to MafA(+) state...
  29. pmc Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation
    Sui Wang
    Program in Developmental Biology, Department of Cell and Developmental Biology, 465 21st Avenue South, Rm 4128, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dev Biol 317:531-40. 2008
    ....
  30. pmc MafA is a dedicated activator of the insulin gene in vivo
    Isabella Artner
    Departments of, Molecular Physiology and Biophysics Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37205, USA
    J Endocrinol 198:271-9. 2008
    ..The closely related MafA and MafB transcription factors are both key mammalian beta-cell regulators...
  31. pmc Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function
    Sui Wang
    Program in Developmental Biology and Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 106:9715-20. 2009
    ..These findings demonstrate that Neurog3 is required not only for initiating endocrine cell differentiation, but also for promoting islet cell maturation and maintaining islet function...
  32. doi MafB restricts M-CSF-dependent myeloid commitment divisions of hematopoietic stem cells
    Sandrine Sarrazin
    Centre d immunologie de Marseille Luminy, Universite Aix Marseille, Campus de Luminy, Case 906, 13288 Marseille Cedex 09, France
    Cell 138:300-13. 2009
    ..Here, we report that the monocytic transcription factor MafB specifically restricts the ability of M-CSF to instruct myeloid commitment divisions in HSCs...
  33. pmc Two distinct origins for Leydig cell progenitors in the fetal testis
    Tony DeFalco
    The Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Dev Biol 352:14-26. 2011
    ..molecular heterogeneity in the interstitium and have characterized new markers of distinct cell types in the gonad: MAFB, C-MAF, and VCAM1...
  34. pmc Hox and Pbx factors control retinoic acid synthesis during hindbrain segmentation
    Antonio Vitobello
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Dev Cell 20:469-82. 2011
    ..These findings reveal a feed-forward mechanism linking Hox-Pbx-dependent RA synthesis during early axial patterning with the establishment of spatially restricted Hox-Pbx activity in the developing hindbrain...
  35. pmc Gata3 is a critical regulator of cochlear wiring
    Jessica M Appler
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 33:3679-91. 2013
    ..As the first auditory-specific regulator of SGN development, Gata3 provides a useful molecular entry point for efforts to engineer SGNs for the restoration of hearing...
  36. pmc MafB is essential for renal development and F4/80 expression in macrophages
    Takashi Moriguchi
    Institute of Basic Medical Sciences, Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba 305 8575, Japan
    Mol Cell Biol 26:5715-27. 2006
    b>MafB is a member of the large Maf family of transcription factors that share similar basic region/leucine zipper DNA binding motifs and N-terminal activation domains...
  37. ncbi Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1
    M Studer
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, Mill Hill, London, UK
    Nature 384:630-4. 1996
    ..These results demonstrate that, as a part of its role in maintaining rhombomere identity, Hoxb-1 is involved in controlling migratory properties of motor neurons in the hindbrain...
  38. ncbi Conserved and distinct roles of kreisler in regulation of the paralogous Hoxa3 and Hoxb3 genes
    M Manzanares
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 126:759-69. 1999
    ..that was found to contain a single high-affinity binding site for the Maf bZIP protein Krml1, encoded by the kreisler gene...
  39. pmc Decreased embryonic retinoic acid synthesis results in a DiGeorge syndrome phenotype in newborn mice
    Julien Vermot
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche, Médicale Université Louis Pasteur, College de France, BP 10142, 67404 Illkirch Cedex, France
    Proc Natl Acad Sci U S A 100:1763-8. 2003
    ....
  40. doi A vertebrate Polycomb response element governs segmentation of the posterior hindbrain
    Angela Sing
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, ON, M5G 1X5, Canada
    Cell 138:885-97. 2009
    ..Here we have identified a vertebrate PRE, PRE-kr, that regulates expression of the mouse MafB/Kreisler gene...
  41. doi MafB protein stability is regulated by the JNK and ubiquitin-proteasome pathways
    Hiroshi Tanahashi
    Department of Neuroplasticity, Research Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto, Japan
    Arch Biochem Biophys 494:94-100. 2010
    b>MafB is a basic leucine zipper transcription factor that plays important roles in development and differentiation processes...
  42. doi Hoxb3 negatively regulates Hoxb1 expression in mouse hindbrain patterning
    Elaine Y M Wong
    Department of Biochemistry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
    Dev Biol 352:382-92. 2011
    ..This study reveals a novel negative regulatory mechanism by which Hoxb3 as a posterior gene serves to restrict Hoxb1 expression in r4 by direct transcriptional repression to maintain the rhombomere identity...
  43. doi Reexpression of oncoprotein MafB in proliferative β-cells and Men1 insulinomas in mouse
    J Lu
    INSERM U1052, Lyon, France
    Oncogene 31:3647-54. 2012
    b>MafB, a member of the large Maf transcription factor family, is essential for the embryonic and terminal differentiation of pancreatic α- and β-cells...
  44. pmc Generation of functional insulin-producing cells in the gut by Foxo1 ablation
    Chutima Talchai
    Naomi Berrie Diabetes Center, Columbia University Medical Center, New York, New York, USA
    Nat Genet 44:406-12, S1. 2012
    ..The data indicate that Neurog3(+) enteroendocrine progenitors require active Foxo1 to prevent differentiation into Ins(+) cells. Foxo1 ablation in gut epithelium may provide an approach to restore insulin production in type 1 diabetes...
  45. doi MafA is critical for maintenance of the mature beta cell phenotype in mice
    Wataru Nishimura
    Department of Metabolic Disorders, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, 1 21 1 Toyama, Shinjuku ku, Tokyo, 162 8655, Japan
    Diabetologia 58:566-74. 2015
    ..This study aims to investigate whether or not v-Maf musculoaponeurotic fibrosarcoma oncogene family, protein A (MafA), a mature beta cell marker, is involved in maintaining mature beta cell phenotypes...
  46. pmc The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cells
    Elizabeth Conrad
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee
    Am J Physiol Endocrinol Metab 310:E91-E102. 2016
    Analysis of MafB(-/-) mice has suggested that the MAFB transcription factor was essential to islet α- and β-cell formation during development, although the postnatal physiological impact could not be studied here because these mutants ..
  47. pmc Loss of MAFB Function in Humans and Mice Causes Duane Syndrome, Aberrant Extraocular Muscle Innervation, and Inner-Ear Defects
    Jong G Park
    Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA Department of Neurology, Boston Children s Hospital, Boston, MA 02115, USA F M Kirby Neurobiology Center, Boston Children s Hospital, Boston, MA 02115, USA Department of Neurology, Harvard Medical School, Boston, MA 02115, USA Duke University School of Medicine, Durham, NC 27710, USA
    Am J Hum Genet 98:1220-7. 2016
    ..Here, we report on three heterozygous loss-of-function MAFB mutations causing DRS and a dominant-negative MAFB mutation causing DRS and deafness...
  48. ncbi The mammal-specific Pdx1 Area II enhancer has multiple essential functions in early endocrine-cell specification and postnatal β-cell maturation
    Yu Ping Yang
    Vanderbilt University Program in Developmental Biology and Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA
    Development . 2016
    ..Therefore, trans-regulatory integration through the mammal-restricted Area II mediates a surprisingly extensive range of progenitor and β-cell-specific functions of the Pdx1 gene...
  49. doi MafB interacts with Gcm2 and regulates parathyroid hormone expression and parathyroid development
    Akiyo Kamitani-Kawamoto
    Laboratory of Molecular and Developmental Biology, Graduate School of Biological Science, Nara Institute of Science and Technology, Ikoma, Japan
    J Bone Miner Res 26:2463-72. 2011
    ..Here we show that transcriptional activator v-maf musculoaponeurotic fibrosarcoma oncogene homologue B (MafB) is developmentally expressed in parathyroid cells after E11.5...
  50. doi The kreisler mutation leads to the loss of intrinsically hypoxia-activated spots in the region of the retrotrapezoid nucleus/parafacial respiratory group
    N Voituron
    UPRES EA 3901, Faculte de Medecine, Universite de Picardie Jules Verne, Amiens, F 80036, France
    Neuroscience 194:95-111. 2011
    ..We aimed to analyze the hypoxic response of ponto-medullary cell populations of kreisler mutant mice...
  51. pmc High MafB expression following burn augments monocyte commitment and inhibits DC differentiation in hemopoietic progenitors
    Kirstin Howell
    Department of Surgery, Mount Sinai Medical Center, Chicago, Illinois, USA
    J Leukoc Biol 91:69-81. 2012
    ..mice exhibit a significant reduction in GATA-1, which is essential for DC development, but express high levels of MafB and M-CSFRs, both associated with monocyte production. GMPs obtained from burn mice differentiated 1...
  52. pmc Renshaw cell interneuron specialization is controlled by a temporally restricted transcription factor program
    Floor J Stam
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Development 139:179-90. 2012
    ....
  53. pmc Membrane β-catenin and adherens junctions in early gonadal patterning
    Alice Fleming
    Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, CA 90095, USA
    Dev Dyn 241:1782-98. 2012
    ..Adherens junctions (AJs) are known for their roles in morphogenesis; we, therefore, examined expression of AJ components including β-catenin, p120 catenin, and cadherins for possible involvement in sex-specific patterning of the gonad...
  54. ncbi Development and cell kinetics of the kreisler (kr-kr) mouse
    R J Ruben
    Laryngoscope 83:1440-68. 1973
  55. ncbi The role of FGF-3 in early inner ear development: an analysis in normal and kreisler mutant mice
    I J McKay
    Department of Developmental Neurobiology, United Medical and Dental School, Guy s Hospital, London, United Kingdom
    Dev Biol 174:370-8. 1996
    ..In kreisler mutant embryos, however, there is no heightened expression in r5 and r6, but the early patch of expression in the ..
  56. ncbi Segmental regulation of Hoxb-3 by kreisler
    M Manzanares
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, London, UK
    Nature 387:191-5. 1997
    ..revealed two blocks of similarity (of 19 and 45 base pairs), which each contain in vitro binding sites for the kreisler protein (Kmrl1), a Maf/b-Zip protein expressed in r5 and r6 (ref. 4)...
  57. ncbi The expression pattern of the mafB/kr gene in birds and mice reveals that the kreisler phenotype does not represent a null mutant
    A Eichmann
    Institut d Embryologie Cellulaire et Moleculaire du CNRS et du College de France, Nogent sur Marne
    Mech Dev 65:111-22. 1997
    ..P. and Barsh, G.S. (1994) Cell 79, 1025-1034). The avian bZIP transcription factor mafB, which shows high homology to kr, has been identified as an interaction partner of c-Ets 1 (Sieweke, M.H...
  58. ncbi Hoxa1 and Hoxb1 synergize in patterning the hindbrain, cranial nerves and second pharyngeal arch
    A Gavalas
    Institut de Génétique et de Biologie Moléculaire and Cellulaire, CNRS INSERM ULP, College de France, BP 163 67404 Illkirch Cedex, CU de Strasbourg, France
    Development 125:1123-36. 1998
    ..Taken together, our results unveil an extensive functional synergy between Hoxa1 and Hoxb1 that was not anticipated from the phenotypes of the simple null mutants...
  59. ncbi The winged helix transcription factor Fkh10 is required for normal development of the inner ear
    M Hulander
    Department of Molecular Biology, The Lundberg Laboratory, Goteborg University, Sweden
    Nat Genet 20:374-6. 1998
    ..These findings implicate Fkh10 as an early regulator necessary for development of both cochlea and vestibulum and identify its human homologue FKHL10 as a previously unknown candidate deafness gene at 5q34...
  60. ncbi Regulation of lens fiber cell differentiation by transcription factor c-Maf
    S Kawauchi
    Center for Tsukuba Advanced Research Alliance and Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba 305 8577, Japan
    J Biol Chem 274:19254-60. 1999
    ..we searched for members of the large Maf family, which are expressed in the mouse lens, and found three, c-Maf, MafB, and Nrl. Of these, the earliest factor expressed in the lens was c-Maf...
  61. ncbi Retinoic acid synthesis and hindbrain patterning in the mouse embryo
    K Niederreither
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, CU de Strasbourg
    Development 127:75-85. 2000
    ..Hoxb1- and Wnt8A-expressing cells are scattered throughout the caudal hindbrain, whereas r5/r8 markers such as kreisler or group 3/4 Hox genes are undetectable or markedly downregulated...
  62. ncbi Control of the migratory pathway of facial branchiomotor neurones
    S Garel
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, 75230 Paris Cedex 05, France
    Development 127:5297-307. 2000
    ..Specific combinations of these markers are associated with each migratory phase in r4, r5 and r6. In Krox20 and kreisler mutant mouse embryos, both of which lack r5, fbm neurones migrate dorsally into the anteriorly positioned r6 and ..
  63. ncbi Roles of retinoic acid receptors in early embryonic morphogenesis and hindbrain patterning
    O Wendling
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, CNRS INSERM ULP College de France, B P 163, 67404 Illkirch Cedex, C U de Strasbourg, France
    Development 128:2031-8. 2001
    ..alpha/A gamma embryos shows a posterior expansion of rhombomere 3 and 4 (R3 and R4) markers, but fails to express kreisler, a normal marker of R5 and R6...
  64. ncbi Retinoic acid rescues inner ear defects in Hoxa1 deficient mice
    M Pasqualetti
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, BP 163 67404 Illkirch Cedex, C U de Strasbourg, France
    Nat Genet 29:34-9. 2001
    ....
  65. ncbi Synergy between Hoxa1 and Hoxb1: the relationship between arch patterning and the generation of cranial neural crest
    A Gavalas
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 128:3017-27. 2001
    ..Furthermore, they demonstrate that early patterning of the separate components of the pharyngeal arches can proceed independently of neural crest cell migration...
  66. ncbi Different respiratory control systems are affected in homozygous and heterozygous kreisler mutant mice
    Fabrice Chatonnet
    Neurobiologie Genetique et Integrative, UPR2216, Centre National de la Recherche Scientifique, Institut de Neurobiologie Alfred Fessard UFR 2218, 91198 Gif sur Yvette Cedex, France
    Eur J Neurosci 15:684-92. 2002
    During embryonic development, restricted expression of the regulatory genes Krox20 and kreisler are involved in segmentation and antero-posterior patterning of the hindbrain neural tube...
  67. pmc Specification of the mammalian cochlea is dependent on Sonic hedgehog
    Martin M Riccomagno
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 16:2365-78. 2002
    ..Taken together, our data support a model whereby auditory cell fates in the otic vesicle are established by the direct action of Shh...
  68. ncbi c-jun regulation and function in the developing hindbrain
    Fatima Mechta-Grigoriou
    Unité Expression Génétique et Maladies, CNRS URA 1644, Institut Pasteur 25, rue du Docteur Roux, 75724 15, Paris Cedex, France
    Dev Biol 258:419-31. 2003
    Hindbrain development is a well-characterised segmentation process in vertebrates. The bZip transcription factor MafB/kreisler is specifically expressed in rhombomeres (r) 5 and 6 of the developing vertebrate hindbrain and is required ..
  69. ncbi Fgf3 and Fgf10 are required for mouse otic placode induction
    Tracy J Wright
    Department of Human Genetics, University of Utah, Salt Lake City, UT 84112 5330, USA
    Development 130:3379-90. 2003
    ..Finally, examination of embryos carrying three out of the four mutant Fgf alleles revealed intermediate phenotypes, suggesting a quantitative requirement for FGF signalling in otic vesicle formation...
  70. ncbi Expression of mouse fibroblast growth factor and fibroblast growth factor receptor genes during early inner ear development
    Tracy J Wright
    Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112 5330, USA
    Dev Dyn 228:267-72. 2003
    ..Fgf16 was expressed in the posterior otic cup and vesicle, suggesting roles in otic cell fate decisions and/or axis formation...
  71. pmc Loss of function but no gain of function caused by amino acid substitutions in the hexapeptide of Hoxa1 in vivo
    Sophie Remacle
    Unit of Developmental Genetics, Universite Catholique de Louvain, Brussels, Belgium
    Mol Cell Biol 24:8567-75. 2004
    ....
  72. pmc FGF8 initiates inner ear induction in chick and mouse
    Raj K Ladher
    Sensory Development, RIKEN Center for Developmental Biology, Chuo Ku, Kobe 650 0047, Japan
    Genes Dev 19:603-13. 2005
    ..Thus, Fgf8 plays a critical upstream role in an FGF signaling cascade required for otic induction in chick and mouse...
  73. ncbi The vHNF1 homeodomain protein establishes early rhombomere identity by direct regulation of Kreisler expression
    Florence A Kim
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, 600 University Avenue, Toronto, Ont, Canada
    Mech Dev 122:1300-9. 2005
    ..The Kreisler (MafB, Krml1, Val) gene is earliest gene expressed in an r5/r6-restricted manner and is essential for r5 and r6 ..
  74. ncbi Changes in Sef levels influence auditory brainstem development and function
    Victoria E Abraira
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 27:4273-82. 2007
    ..These results show both increases and decreases in Sef levels affect the assembly and function of the auditory brainstem...
  75. ncbi Differential requirements for FGF3, FGF8 and FGF10 during inner ear development
    Laura Cecilia Zelarayan
    Center for Molecular Neurobiology, University of Hamburg, Falkenried 94, D 20251 Hamburg, Germany
    Dev Biol 308:379-91. 2007
    ..Together these results provide important insights into how the spatial and temporal expression of various FGFs controls different steps of inner ear formation during vertebrate development...
  76. pmc Fgf3 is required for dorsal patterning and morphogenesis of the inner ear epithelium
    Ekaterina P Hatch
    Department of Human Genetics, University of Utah, Salt Lake City, UT 84112 5330, USA
    Development 134:3615-25. 2007
    ..data on otic dysmorphogenesis in Fgf3 mutants, which show a range of malformations similar to those of Mafb (Kreisler), Hoxa1 and Gbx2 mutants, the most common phenotype being failure of endolymphatic duct and common crus formation,..
  77. doi Gene expression analyses on embryonic external genitalia: identification of regulatory genes possibly involved in masculinization processes
    Hisayo Nishida
    Center for Animal Resources and Development CARD, Graduate School of Medical and Pharmaceutical Sciences, and Global COE Cell Fate Regulation Research and Education Unit, Kumamoto University, Kumamoto, Japan
    Congenit Anom (Kyoto) 48:63-7. 2008
    ..From our studies we have identified candidate genes, Cyp1b1, Fkbp51 and MafB as potential androgen targets during mouse GT masculinization.
  78. pmc Postnatal expansion of the pancreatic beta-cell mass is dependent on survivin
    Yuying Jiang
    The Research Institute at Nationwide Children s Hospital, Columbus, Ohio, USA
    Diabetes 57:2718-27. 2008
    ..The objective of this study was to determine whether a gene critical for cell division and cell survival in cancer cells, survivin, might also be important for beta-cells...
  79. pmc Identification and characterization of VPO1, a new animal heme-containing peroxidase
    Guangjie Cheng
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Free Radic Biol Med 45:1682-94. 2008
    ..5 mM. When co-expressed in cells, VPO1 can use H(2)O(2) produced by NADPH oxidase enzymes. VPO1 is likely to carry out peroxidative reactions previously attributed exclusively to myeloperoxidase in the vascular system...
  80. doi Genetic disruption of CYP26B1 severely affects development of neural crest derived head structures, but does not compromise hindbrain patterning
    Glenn MacLean
    Department of Pathology, Division of Cancer Biology and Genetics, Queen s University, Kingston, Ontario, Canada
    Dev Dyn 238:732-45. 2009
    ..These data suggest different periods of sensitivity of anterior and posterior hindbrain neural crest derivatives to elevated levels of RA in the absence of CYP26B1...
  81. doi Inhibitory and excitatory subtypes of cochlear nucleus neurons are defined by distinct bHLH transcription factors, Ptf1a and Atoh1
    Tomoyuki Fujiyama
    Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, NCNP, Kodaira, Tokyo 187 8502, Japan
    Development 136:2049-58. 2009
    ....
  82. doi Neither MafA/L-Maf nor MafB is essential for lens development in mice
    Takashi Takeuchi
    Department of Anatomy and Embryology, Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Genes Cells 14:941-7. 2009
    ..Here, we report the roles of other large Mafs, MafA/L-Maf and MafB, during mouse lens development. MafA/L-Maf and MafB were expressed in lens epithelial cells and fibre cells at E12...
  83. pmc Neurog3 gene dosage regulates allocation of endocrine and exocrine cell fates in the developing mouse pancreas
    Sui Wang
    Program in Developmental Biology and Department of Cell and Developmental Biology, Center for Stem Cell Biology, Vanderbilt University Medical Center, 465 21st Avenue South, Rm 4128, Vanderbilt Medical Center, Nashville, TN 37232, USA
    Dev Biol 339:26-37. 2010
    ..The control of Neurog3+ cell number and the Neurog3 threshold-dependent endocrine differentiation mechanism combine to select a specific proportion of pancreatic progenitor cells to adopt the islet cell fate...
  84. doi c-Maf and MafB transcription factors are differentially expressed in Huxley's and Henle's layers of the inner root sheath of the hair follicle and regulate cuticle formation
    Masashi Miyai
    Laboratory of Molecular and Developmental Biology, Graduate School of Biological Science, Nara Institute of Science and Technology, 8916 5 Takayama cho, Ikoma 630 0192, Japan
    J Dermatol Sci 57:178-82. 2010
    ..The IRS forms a follicular wall in the hair canal and helps guide the developing hair shaft. c-Maf and MafB, members of the Maf family of transcription factors, play important roles in the developmental processes of various ..
  85. pmc Sonic hedgehog is required for vascular outgrowth in the hindbrain choroid plexus
    Corinne M Nielsen
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Dev Biol 340:430-7. 2010
    ....
  86. pmc The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression
    Aouatef Ait-Lounis
    Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Centre Medical Universitaire, Geneva, Switzerland
    Diabetes 59:1674-85. 2010
    ..The objective of this work was to unravel the cellular and molecular mechanisms underlying this deficiency...
  87. pmc The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3
    Hwijin Kim
    Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Immunol 11:743-50. 2010
    ..We report that the transcription factor MafB thwarts auto-amplification by a metastable switch activity...
  88. pmc MafA and MafB regulate genes critical to beta-cells in a unique temporal manner
    Isabella Artner
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Diabetes 59:2530-9. 2010
    ..factors are essential to pancreatic islet β-cell development, proliferation, and activity, including MafA and MafB. However, MafA and MafB are distinct from others in regard to temporal and islet cell expression pattern, with β-..
  89. pmc Influence and timing of arrival of murine neural crest on pancreatic beta cell development and maturation
    Jennifer L Plank
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dev Biol 349:321-30. 2011
    ..Together, these data demonstrate that the neural crest is a critical regulator of beta cell development on two levels: by negatively regulating beta cell proliferation and by promoting beta cell maturation...
  90. pmc The role of sonic hedgehog-Gli2 pathway in the masculinization of external genitalia
    Shinichi Miyagawa
    Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
    Endocrinology 152:2894-903. 2011
    ..The current study identified hedgehog signaling pathway as a key factor not only for initial development but also for sexually dimorphic development of the external genitalia in coordination with androgen signaling...
  91. pmc Context-specific α- to-β-cell reprogramming by forced Pdx1 expression
    Yu Ping Yang
    Vanderbilt University Program in Developmental Biology, Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Genes Dev 25:1680-5. 2011
    ..Our findings reveal that Pdx1 can work single-handedly as a potent context-dependent autonomous reprogramming agent, and suggest a postnatal differentiation evaluation stage involved in normal endocrine maturation...
  92. pmc Involvement of retinol dehydrogenase 10 in embryonic patterning and rescue of its loss of function by maternal retinaldehyde treatment
    Muriel Rhinn
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch F 67404, France
    Proc Natl Acad Sci U S A 108:16687-92. 2011
    ..These results underscore the importance of maternal retinoids in preventing congenital birth defects, and lead to a revised model of the importance of RDH10 and RALDHs in controlling embryonic RA distribution...
  93. ncbi Key roles of retinoic acid receptors alpha and beta in the patterning of the caudal hindbrain, pharyngeal arches and otocyst in the mouse
    V Dupé
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, CNRS INSERM ULP College de France, B P 163, CU de Strasbourg, France
    Development 126:5051-9. 1999
    ..In the mutant hindbrain, the expression domain of kreisler is twice its normal size and the caudal stripe of Krox-20 extends into the presumptive rhombomeres 6 and 7 region...
  94. ncbi Cloning and characterization of promoter of the mouse mafB gene
    K Huang
    Department of Biochemistry, Hokkaido University School of Medicine, Sapporo, Japan
    Hokkaido Igaku Zasshi 74:419-30. 1999
    The MafB transcription factor plays a pivotal role in controlling the development and differentiation. The author reports the isolation and analysis of genomic clone of the mouse mafB gene...
  95. ncbi THE ABNORMALITIES OF THE INNER EAR IN KREISLER MICE
    M S Deol
    J Embryol Exp Morphol 12:475-90. 1964
  96. ncbi Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development
    Helle Heibroch Petersen
    Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    FEBS Lett 565:23-7. 2004
    ..screen for the ICD that depends on the activation of the Ras-signaling pathway and uncovered the transcription factor MafB as novel ICD interacting protein...
  97. ncbi Expression of maf-B mRNA in the epithelium around the eyelid closure of the mouse eye at embryonic day 18
    Satoru Kase
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, N15 W7, Kita ku, 060 8638, Sapporo, Japan
    Anat Embryol (Berl) 209:153-6. 2004
    ..In contrast, basal cells in the eyelid closure and in the epidermis, as well as keratinizing cells, did not express maf-B. These data indicate that maf-B mRNA is expressed during development of the eyelid closure...
  98. ncbi New regulatory interactions and cellular responses in the isthmic organizer region revealed by altering Gbx2 expression
    James Y H Li
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Development 132:1971-81. 2005
    ..Our studies provide new insights into the regulatory interactions that maintain isthmic organizer gene expression and the consequences of altered levels of organizer gene expression on cell survival...
  99. ncbi Direct regulation of vHnf1 by retinoic acid signaling and MAF-related factors in the neural tube
    Marie Pouilhe
    INSERM, U784, 46 rue d Ulm, 75230 Paris Cedex 05, France
    Dev Biol 309:344-57. 2007
    ..Our data suggest that MAFB, which is itself regulated by vHNF1, acts as a positive modulator of vHnf1 in r5 and r6, whereas another MAF-..
  100. pmc Pitx3 controls multiple aspects of lens development
    Olga Medina-Martinez
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Dev Dyn 238:2193-201. 2009
    ..In general, our study shows that the abnormal phenotype of the ak lenses is not due to just one molecular pathway, rather in the absence of Pitx3 expression multiple aspects of lens development are disrupted...
  101. pmc Transcription factor C/EBPbeta isoform ratio regulates osteoclastogenesis through MafB
    Jeske J Smink
    Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    EMBO J 28:1769-81. 2009
    ..C/EBPbeta mutant mouse strains exhibit increased bone resorption and attenuated expression of MafB, a negative regulator of osteoclastogenesis...

Research Grants3

  1. Role of Gbx2 and Otx2 in the mes-met organizer function
    James Li; Fiscal Year: 2003
    ..abstract_text> ..
  2. Molecular Development of the Endolymphatic Duct and Sac
    Daniel Choo; Fiscal Year: 2005
    ..Therefore, data on the molecular development of the ELDS are very relevant. By focusing on a mouse mutant (kreisler) with an ELDS phenotype, this application seeks to define the molecular pathways involved in induction and ..
  3. International Consortium to Identify Genes and Interactions Controlling Oral Clef
    Terri Beaty; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..