Lyz2

Summary

Gene Symbol: Lyz2
Description: lysozyme 2
Alias: AI326280, Lys, Lysm, Lyzf2, Lyzs, Lzm, Lzm-s1, Lzp, lysozyme C-2, 1,4-beta-N-acetylmuramidase C, lysozyme C type M, lysozyme f2
Species: mouse

Top Publications

  1. ncbi Insertion of enhanced green fluorescent protein into the lysozyme gene creates mice with green fluorescent granulocytes and macrophages
    N Faust
    Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Blood 96:719-26. 2000
  2. pmc NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta
    Florian R Greten
    Second Department of Medicine, Klinikum rechts der Isar, Technical University Munich, 81675 Germany
    Cell 130:918-31. 2007
  3. pmc Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells
    Jennifer Martinez
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 108:17396-401. 2011
  4. pmc Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation
    Craig T Lefort
    Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Blood 119:4275-82. 2012
  5. pmc Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation
    Shannon E Mullican
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 25:2480-8. 2011
  6. pmc Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation
    Hongwei Qin
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 109:5004-9. 2012
  7. pmc HIF-1alpha is essential for myeloid cell-mediated inflammation
    Thorsten Cramer
    Molecular Biology Section, Division of Biological Sciences, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Cell 112:645-57. 2003
  8. doi Type I interferon inhibits interleukin-1 production and inflammasome activation
    Greta Guarda
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Immunity 34:213-23. 2011
  9. pmc Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cells
    Cesar A Corzo
    H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL, 33612, USA
    J Immunol 182:5693-701. 2009
  10. doi Deletion of PPAR gamma in alveolar macrophages is associated with a Th-1 pulmonary inflammatory response
    Anagha Malur
    Department of Internal Medicine, Division of Pulmonary and Critical Care and Sleep Medicine, East Carolina University, Greenville, NC 27834, USA
    J Immunol 182:5816-22. 2009

Research Grants

Detail Information

Publications171 found, 100 shown here

  1. ncbi Insertion of enhanced green fluorescent protein into the lysozyme gene creates mice with green fluorescent granulocytes and macrophages
    N Faust
    Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Blood 96:719-26. 2000
    ..This was achieved by knocking the enhanced GFP (EGFP) gene into the murine lysozyme M (lys) locus and using a targeting vector, which contains a neomycin resistant (neo) gene flanked by LoxP sites and "..
  2. pmc NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta
    Florian R Greten
    Second Department of Medicine, Klinikum rechts der Isar, Technical University Munich, 81675 Germany
    Cell 130:918-31. 2007
    ..These results unravel an unanticipated role for IKKbeta-dependent NF-kappaB signaling in the negative control of IL-1beta production and highlight potential complications of long-term IKKbeta inhibition...
  3. pmc Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells
    Jennifer Martinez
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Proc Natl Acad Sci U S A 108:17396-401. 2011
    ..Therefore, the consequence of phagocytosis of dead cells is strongly affected by those components of the autophagy pathway involved in LAP...
  4. pmc Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation
    Craig T Lefort
    Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    Blood 119:4275-82. 2012
    ..We conclude that talin-1 and kindlin-3 serve distinct functions in LFA-1 activation...
  5. pmc Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation
    Shannon E Mullican
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 25:2480-8. 2011
    ..Thus, HDAC3 functions in alternative activation as a brake whose release could be of benefit in the treatment of multiple inflammatory diseases...
  6. pmc Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation
    Hongwei Qin
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 109:5004-9. 2012
    ..These findings indicate that myeloid cell SOCS3 provides protection from EAE through deactivation of neuroinflammatory responses...
  7. pmc HIF-1alpha is essential for myeloid cell-mediated inflammation
    Thorsten Cramer
    Molecular Biology Section, Division of Biological Sciences, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Cell 112:645-57. 2003
    ..This role for HIF-1alpha demonstrates its direct regulation of survival and function in the inflammatory microenvironment...
  8. doi Type I interferon inhibits interleukin-1 production and inflammasome activation
    Greta Guarda
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Immunity 34:213-23. 2011
    ..Our findings may thus explain the effectiveness of type I IFN in the treatment of inflammatory diseases but also the observed "weakening" of the immune system after viral infection...
  9. pmc Mechanism regulating reactive oxygen species in tumor-induced myeloid-derived suppressor cells
    Cesar A Corzo
    H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL, 33612, USA
    J Immunol 182:5693-701. 2009
    ..These findings expand our fundamental understanding of the biology of MDSC and may also open new opportunities for therapeutic regulation of these cells in cancer...
  10. doi Deletion of PPAR gamma in alveolar macrophages is associated with a Th-1 pulmonary inflammatory response
    Anagha Malur
    Department of Internal Medicine, Division of Pulmonary and Critical Care and Sleep Medicine, East Carolina University, Greenville, NC 27834, USA
    J Immunol 182:5816-22. 2009
    ..These results suggest that lack of PPARgamma in alveolar macrophages disrupts lung homeostasis and results in a Th1-like inflammatory response...
  11. pmc The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages
    Ivan Dzhagalov
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Blood 109:1620-6. 2007
    ..These data suggest that Mcl-1 plays a nonredundant role in promoting the survival of neutrophils but not macrophages...
  12. pmc Biphasic and dosage-dependent regulation of osteoclastogenesis by β-catenin
    Wei Wei
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9041, USA
    Mol Cell Biol 31:4706-19. 2011
    ..Importantly, these findings suggest that Wnt activation is a more effective treatment for skeletal fragility than previously recognized that confers dual anabolic and anti-catabolic benefits...
  13. pmc Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice
    Rafal Pawlinski
    Hematology and Oncology Division, Department of Medicine, University of North Carolina at Chapel Hill, NC, USA
    Blood 116:806-14. 2010
    ..levels were significantly reduced in endotoxemic mice lacking the TF gene in either myeloid cells (TF(flox/flox),LysM(Cre) mice) or in both endothelial cells (ECs) and hematopoietic cells (TF(flox/flox),Tie-2(Cre) mice)...
  14. doi Myeloid PTEN promotes inflammation but impairs bactericidal activities during murine pneumococcal pneumonia
    Gernot Schabbauer
    Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Austrian Academy of Sciences, Vienna, Austria
    J Immunol 185:468-76. 2010
    ....
  15. pmc Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones
    Andrea L Hevener
    Department of Medicine, Division of Endocrinology and Metabolism, UCSD, La Jolla, California, USA
    J Clin Invest 117:1658-69. 2007
    ..These findings reveal an essential role of PPAR gamma in macrophages for the maintenance of whole-body insulin action and in mediating the antidiabetic actions of TZDs...
  16. ncbi Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
    K Takeda
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
    Immunity 10:39-49. 1999
    ..The mice show a polarized immune response toward the Th1 type and develop chronic enterocolitis with age. Taken together, Stat3 plays a critical role in deactivation of macrophages and neutrophils mainly exerted by IL-10...
  17. pmc Interplay of hepatic and myeloid signal transducer and activator of transcription 3 in facilitating liver regeneration via tempering innate immunity
    Hua Wang
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Hepatology 51:1354-62. 2010
    ....
  18. doi IFN-{gamma}-mediated inhibition of MAPK phosphatase expression results in prolonged MAPK activity in response to M-CSF and inhibition of proliferation
    Annabel F Valledor
    Nuclear Receptor Group, Department of Physiology, School of Biology, University of Barcelona, Barcelona, Spain
    Blood 112:3274-82. 2008
    ..These data suggest that subtle changes in the time course of activity of members of the MAPK family contribute to the antiproliferative effects of IFN-gamma in macrophages...
  19. pmc TNF-alpha-dependent loss of IKKbeta-deficient myeloid progenitors triggers a cytokine loop culminating in granulocytosis
    Arun K Mankan
    Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University Munich, 81675 Munich, Germany
    Proc Natl Acad Sci U S A 108:6567-72. 2011
    ..These results unravel so far unanticipated direct and indirect functions for IKKβ in myeloid progenitor survival and maintenance of innate and Th17 immunity and raise concerns about long-term IKKβ inhibition in IL-17-mediated diseases...
  20. pmc Myeloid-specific deletion of tumor suppressor PTEN augments neutrophil transendothelial migration during inflammation
    Bara Sarraj
    Department of Lab Medicine, Children s Hospital, and
    J Immunol 182:7190-200. 2009
    ..Collectively, these results demonstrate that PTEN deletion in neutrophils enhances their invasivity and recruitment to inflamed sites more likely by raising the cell physical capability to cross the vascular and tissue barriers...
  21. doi Generation of mice with a conditional Stat1 null allele
    Barbara Wallner
    Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Veterinarplatz 1, 1210, Vienna, Austria
    Transgenic Res 21:217-24. 2012
    ..The conditional Stat1 null allele represents an important tool for identifying novel and cell-autonomous STAT1 functions in infection and cancer...
  22. pmc Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice
    Edwin Kanters
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Clin Invest 112:1176-85. 2003
    ..Our data show that inhibition of the NF-kappaB pathway in macrophages leads to more severe atherosclerosis in mice, possibly by affecting the pro- and anti-inflammatory balance that controls the development of atherosclerosis...
  23. pmc Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function
    Desiree A Steimer
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Blood 113:2805-15. 2009
    ..Thus, MCL-1 plays selective roles in myeloid development, being required for neutrophil development and setting the threshold for apoptosis during a macrophage effector response...
  24. pmc The low-density lipoprotein receptor-related protein 1 mediates tissue-type plasminogen activator-induced microglial activation in the ischemic brain
    Chen Zhang
    Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Pathol 174:586-94. 2009
    ..In summary, our results indicate that the interaction between tPA and LRP1 induces microglial activation with the generation of an inflammatory response in the ischemic brain, suggesting a cytokine-like role for tPA in the CNS...
  25. pmc Inhibitor of NF-kappa B kinases alpha and beta are both essential for high mobility group box 1-mediated chemotaxis [corrected]
    Marianna Penzo
    Vita Salute San Raffaele University, School of Medicine, San Raffaele Scientific Institute, Milano, Italy
    J Immunol 184:4497-509. 2010
    ..Thus, proinflammatory HMGB1 chemotactic responses mechanistically require the differential collaboration of both IKK-dependent NF-kappaB signaling pathways...
  26. pmc E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin alphaLbeta2-mediated slow leukocyte rolling
    Tadayuki Yago
    Cardiovascular Biology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Blood 116:485-94. 2010
    ..Thus, E-selectin triggers common signals through distinct neutrophil glycoproteins to induce alpha(L)beta(2)-dependent slow rolling...
  27. doi RAGE and ICAM-1 cooperate in mediating leukocyte recruitment during acute inflammation in vivo
    David Frommhold
    Section of Neonatal Medicine, University of Heidelberg, Heidelberg, Germany
    Blood 116:841-9. 2010
    ....
  28. pmc Mouse atonal homolog 1 directs intestinal progenitors to secretory cell rather than absorptive cell fate
    Kelli L VanDussen
    Department of Molecular and Integrative Physiology, The University of Michigan, Ann Arbor, MI 48109, USA
    Dev Biol 346:215-23. 2010
    ..Thus, Math1 is a key effector directing multipotential precursors to adopt secretory and not absorptive cell fate...
  29. pmc Sphingosine-1-phosphate lyase deficiency produces a pro-inflammatory response while impairing neutrophil trafficking
    Maria L Allende
    Genetics of Development and Disease Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 286:7348-58. 2011
    ..Thus, a genetic block in S1P degradation elicits a pro-inflammatory response but impairs neutrophil migration from blood into tissues...
  30. pmc Deactivation of phosphatidylinositol 3,4,5-trisphosphate/Akt signaling mediates neutrophil spontaneous death
    Daocheng Zhu
    Department of Pathology, Joint Program in Transfusion Medicine, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:14836-41. 2006
    ..Thus, we establish Akt deactivation as a causal mediator of neutrophil spontaneous death...
  31. ncbi Suppressor of cytokine signaling-1 in T cells and macrophages is critical for preventing lethal inflammation
    Mark M W Chong
    St Vincent s Institute, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
    Blood 106:1668-75. 2005
    ..A dysregulated cytokine network between T cells and macrophages is thus associated with this inflammatory disease. These findings indicate that SOCS-1 is critical in both T cells and macrophages for preventing uncontrolled inflammation...
  32. pmc Peroxisome proliferator-activated receptor-gamma regulates the expression of alveolar macrophage macrophage colony-stimulating factor
    Tracey L Bonfield
    Department of Pediatrics, Case Western Reserve University, Cleveland, OH 44109, USA
    J Immunol 181:235-42. 2008
    ..of PPARgamma in alveolar macrophage homeostasis, we generated myeloid-specific PPARgamma knockout mice using the Lys-Cre method to knock out the floxed PPARgamma gene...
  33. ncbi Impairment of alternative macrophage activation delays cutaneous leishmaniasis in nonhealing BALB/c mice
    Christoph Holscher
    Institute for Infectious Diseases and Molecular Medicine and Division of Immunology, Health Science Faculty, University of Cape Town, Cape Town, South Africa
    J Immunol 176:1115-21. 2006
    ..Together, these results suggest that alternative macrophage activation contributes to susceptibility in cutaneous leishmaniasis...
  34. ncbi Macrophage low-density lipoprotein receptor-related protein deficiency enhances atherosclerosis in ApoE/LDLR double knockout mice
    L Hu
    Vascular Medicine Unit, Department of General Internal Medicine, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 26:2710-5. 2006
    ..In the present study, we investigated the in vivo role of macrophage specific LRP in atherogenesis independent of its role in the uptake of lipoproteins...
  35. pmc Essential crosstalk between myeloid and lymphoid cells for development of chronic colitis in myeloid-specific signal transducer and activator of transcription 3-deficient mice
    Wolfgang Reindl
    II Medizinische Klinik and Poliklinik, Klinikum rechts der Isar, Munich, Germany
    Immunology 120:19-27. 2007
    ..Yet when these cells can interact with lymphocytes their increased costimulatory potential will trigger an overshooting inflammatory response...
  36. ncbi Macrophage deletion of p38alpha partially impairs lipopolysaccharide-induced cellular activation
    Young Jun Kang
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 180:5075-82. 2008
    ..Our in vivo studies with two murine models showed that p38alpha is involved in sepsis. Collectively, our data demonstrate that p38alpha is an important player in inflammatory responses...
  37. pmc Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury
    Norio Horiguchi
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland
    Gastroenterology 134:1148-58. 2008
    ..Signal transducer and activator of transcription 3 (STAT3) is known to be activated in human alcoholic liver disease, but its role in the pathogenesis of alcoholic liver injury remains obscure...
  38. pmc Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells
    Masashi Ohtani
    Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan
    Blood 112:635-43. 2008
    ..The signaling pathway downstream of PI3K would be a good target to modulate the Th1/Th2 balance in immune responses in vivo...
  39. pmc Macrophage deficiency of p38alpha MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice
    Tracie A Seimon
    Department of Medicine, Division of Molecular Medicine, Columbia University, PH 9 405, 630 W 168th Street, New York, New York 10032, USA
    J Clin Invest 119:886-98. 2009
    ..Our results demonstrate that p38alpha MAPK may play a critical role in suppressing ER stress-induced macrophage apoptosis in vitro and advanced lesional macrophage apoptosis in vivo...
  40. ncbi HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA forming microsatellite
    Henry K Bayele
    Department of Biochemistry and Molecular Biology, University College London, NW3 2PF, United Kingdom
    Blood 110:3039-48. 2007
    ..This report also suggests that microsatellites may play critical roles in the directional evolution of complex heritable traits by regulating gene expression phenotypes...
  41. ncbi Identifying the relative contributions of Rac1 and Rac2 to osteoclastogenesis
    Yongqiang Wang
    CIHR Group in Matrix Dynamics, University of Toronto, Toronto, Ontario, Canada
    J Bone Miner Res 23:260-70. 2008
    ..Rac1 is the key Rac isoform responsible for regulating ROS generation and the actin cytoskeleton during the multiple stages of osteoclast differentiation...
  42. pmc Factor Xa binding to annexin 2 mediates signal transduction via protease-activated receptor 1
    Gourab Bhattacharjee
    Scripps Research Institute, SP 258, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Circ Res 102:457-64. 2008
    ..We propose that annexin 2 serves to regulate factor Xa signaling specifically in the absence of cell surface TF and may thus play physiological or pathological roles when factor Xa is generated in a TF-depleted environment...
  43. pmc Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor
    Alban Gaultier
    Department of Pathology, University of California San Diego School of Medicine, La Jolla, CA 92093 0612, USA
    Blood 111:5316-25. 2008
    ..We propose that LRP-1 suppresses expression of inflammatory mediators indirectly, by regulating TNFR1-dependent cell signaling through the I kappaB kinase-NF-kappaB pathway...
  44. doi The role of the transcription factor AP-1 in colitis-associated and beta-catenin-dependent intestinal tumorigenesis in mice
    P Hasselblatt
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, Vienna, Austria
    Oncogene 27:6102-9. 2008
    ..Moreover, tumorigenesis was not altered in mice lacking junB, junD, c-fos, fra-1 or fra-2, suggesting that inhibition of c-Jun or other single AP-1 proteins is not a determining factor in colitis-associated cancer in mice...
  45. pmc Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens
    Karim C El Kasmi
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38015, USA
    Nat Immunol 9:1399-406. 2008
    ..Specific elimination of Arg1 in macrophages favored host survival during T. gondii infection and decreased lung bacterial load during tuberculosis infection...
  46. ncbi Type I IFN-mediated protection of macrophages and dendritic cells secures control of murine coronavirus infection
    Luisa Cervantes-Barragan
    Research Department, Kantonal Hospital St Gallen, St Gallen, Switzerland
    J Immunol 182:1099-106. 2009
    ..This genetic analysis revealed that IFNAR expression on LysM+ macrophages and CD11c+ dendritic cells was most important for the early containment of MHV within secondary ..
  47. doi Enhanced Th1 and Th17 responses and arthritis severity in mice with a deficiency of myeloid cell-specific interleukin-1 receptor antagonist
    Celine Lamacchia
    University of Geneva School of Medicine, Geneva, Switzerland
    Arthritis Rheum 62:452-62. 2010
    ..The purpose of this study was to investigate the role of IL-1Ra produced specifically by myeloid cells in the control of collagen-induced arthritis (CIA) by using myeloid cell-specific IL-1Ra-deficient mice (IL-1Ra(DeltaM))...
  48. pmc Repetitive sequence involvement in the duplication and divergence of mouse lysozyme genes
    M Cross
    Genzentrum, Max Planck Institut fur Biochemie, Martinsried, FRG
    EMBO J 9:1283-8. 1990
    ....
  49. pmc Mouse lysozyme M gene: isolation, characterization, and expression studies
    M Cross
    Genzentrum, Max Planck Institut fur Biochemie, Martinsried, Federal Republic of Germany
    Proc Natl Acad Sci U S A 85:6232-6. 1988
    ..Sites of protein accumulation, rather than gene expression, have been identified by comparative quantitation of mRNA and enzyme levels...
  50. ncbi Differentiation of the mononuclear phagocyte system during mouse embryogenesis: the role of transcription factor PU.1
    A M Lichanska
    Department of Microbiology and Centre for Molecular and Cellular Biology, University of Queensland, Queensland, Australia
    Blood 94:127-38. 1999
    ..The results support previous evidence that yolk sac-derived fetal phagocytes are functionally distinct from those arising in the liver and develop via a different pathway...
  51. ncbi Conditional gene targeting in macrophages and granulocytes using LysMcre mice
    B E Clausen
    Institute for Genetics, University of Cologne, Germany
    Transgenic Res 8:265-77. 1999
    ..In contrast, no significant deletion was observed in tail DNA or purified T and B cells. Taken together, LysMcre mice allow for both specific and highly efficient Cre-mediated deletion of loxP-flanked target genes in myeloid cells...
  52. ncbi Hematopoietic stem cells expressing the myeloid lysozyme gene retain long-term, multilineage repopulation potential
    Min Ye
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Immunity 19:689-99. 2003
    ..Our results demonstrate that lysozyme expression does not mark myeloid commitment and that long-term repopulation potential is maintained in primed HSCs...
  53. ncbi Mouse lysozyme M is important in pulmonary host defense against Klebsiella pneumoniae infection
    Philipp Markart
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Am J Respir Crit Care Med 169:454-8. 2004
    ..01). Deficiency of lysozyme M in the lungs increased susceptibility to K. pneumoniae infection, whereas increased expression of lysozyme conferred resistance to infection and enhanced survival...
  54. ncbi SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling
    Akiko Kimura
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 279:6905-10. 2004
    ..factor (G-CSF) signaling in vivo, we compared neutrophils from two types of conditional knockout mice, LysM-Cre:SOCS3(fl/fl) mice and Tie2-Cre:SOCS3(fl/fl) mice, in which the Socs3 gene had been deleted in mature ..
  55. pmc Mice lacking JunB are osteopenic due to cell-autonomous osteoblast and osteoclast defects
    Lukas Kenner
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    J Cell Biol 164:613-23. 2004
    ..Thus, these data reveal a novel function of JunB as a positive regulator controlling primarily osteoblast as well as osteoclast activity...
  56. ncbi Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology
    De Broski R Herbert
    University of Cape Town, Health Sciences Faculty, 7925 Cape Town, South Africa
    Immunity 20:623-35. 2004
    Macrophage/neutrophil-specific IL-4 receptor alpha-deficient mice (LysM(Cre)IL-4Ralpha(-/flox)) were generated to understand the role of IL-4/IL-13 responsive myeloid cells during Type 2 immune responses...
  57. ncbi IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
    Florian R Greten
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla 92093, USA
    Cell 118:285-96. 2004
    ..In addition to suppressing apoptosis in advanced tumors, IKKbeta may link inflammation to cancer...
  58. ncbi Distinct and nonredundant in vivo functions of TNF produced by t cells and macrophages/neutrophils: protective and deleterious effects
    Sergei I Grivennikov
    Laboratory of Molecular Immunology, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences and Belozersky Institute of Physico Chemical Biology, 32 Vavilov Str, 119991 Moscow, Russia
    Immunity 22:93-104. 2005
    ..Our data suggest that T-cell-specific TNF ablation may provide a therapeutic advantage over systemic blockade...
  59. pmc Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis
    Kersi N Pestonjamasp
    Departments of Immunology and Cell Biology IMM14, The Scripps Research Institute, La Jolla, CA, USA
    Blood 108:2814-20. 2006
    ..We conclude that Rac plays both positive and negative roles in the organization of the Rhomyosin "backness" program, thereby promoting stable polarity in chemotaxing neutrophils...
  60. pmc Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells
    Giovanna Gallina
    Istituto Oncologico Veneto, Padua, Italy
    J Clin Invest 116:2777-90. 2006
    ..Moreover, our data show how the inflammatory response elicited by tumors had detrimental effects on the adaptive immune system and suggest novel approaches for the treatment of tumor-induced immune dysfunctions...
  61. ncbi Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA
    Lisa Siewe
    Department of Dermatology, University of Cologne, Cologne, Germany
    Eur J Immunol 36:3248-55. 2006
    ..These results show that different innate immune responses can be subject to control by IL-10 from different cellular sources...
  62. ncbi Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1
    Miki Nishio
    Department of Pathology and Immunology, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Nat Cell Biol 9:36-44. 2007
    ..By directing where PtdIns(3,4,5)P(3) accumulates, SHIP1 governs the formation of the leading edge and polarization required for chemotaxis...
  63. pmc Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions
    Kulandayan K Subramanian
    Department of Pathology, Harvard Medical School, Boston, MA, USA
    Blood 109:4028-37. 2007
    ..Thus, as a physiologic-negative regulator, PTEN should be a promising therapeutic target for modulating neutrophil functions in various infectious and inflammatory diseases...
  64. ncbi Deletion of macrophage LDL receptor-related protein increases atherogenesis in the mouse
    Cheryl D Overton
    Atherosclerosis Research Unit, Division of Cardiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Circ Res 100:670-7. 2007
    ..Our data support the hypothesis that macrophage LRP modulates atherogenesis through regulation of inflammatory responses...
  65. pmc Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance
    Justin I Odegaard
    Division of Endocrinology, Metabolism and Gerontology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305 5103, USA
    Nature 447:1116-20. 2007
    ....
  66. ncbi Selective expansion of foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-deficient dendritic cells
    Yumiko Matsumura
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Immunol 179:2170-9. 2007
    ..These results indicate an important role of SOCS3 in determining on immunity or tolerance by DCs...
  67. ncbi Cutting edge: TNF-alpha-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock
    Keisuke Horiuchi
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Immunol 179:2686-9. 2007
    ..These findings corroborate that TACE is the major endotoxin-stimulated TNF sheddase in mouse myeloid cells in vivo, thereby further validating TACE as a principal target for the treatment of TNF-dependent pathologies...
  68. ncbi NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells
    Shuting Bai
    Departments of Pathology and Immunology, Molecular Biology and Pharmacology, and Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Biol Chem 283:6509-18. 2008
    ..These observations raise caution that therapeutic inhibition of NOTCH signaling may adversely accelerate bone loss in humans...
  69. doi Hfe acts in hepatocytes to prevent hemochromatosis
    Maja Vujic Spasic
    Department of Pediatric Oncology, Hematology and Immunology, University Hospital of Heidelberg, 69120 Heidelberg, Germany
    Cell Metab 7:173-8. 2008
    ..This work demonstrates that local Hfe expression in hepatocytes serves to maintain physiological iron homeostasis, answering a long-standing question in medicine and explaining earlier clinical observations...
  70. pmc Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors
    Craig D Jude
    Department of Genetics and Norris Cotton Cancer Center, Dartmouth Medical School, 725 Remsen, HB7400, Hanover, NH 03755, USA
    Cell Stem Cell 1:324-37. 2007
    ..These studies demonstrate that Mll plays selective and independent roles within the hematopoietic system, maintaining quiescence in HSCs and promoting proliferation in progenitors...
  71. pmc Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance
    Justin I Odegaard
    Division of Endocrinology, Metabolism and Gerontology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5103, USA
    Cell Metab 7:496-507. 2008
    ..Taken together, these data suggest an unexpected beneficial role for alternatively activated Kupffer cells in metabolic syndrome and type 2 diabetes...
  72. pmc Murine low-density lipoprotein receptor-related protein 1 (LRP) is required for phagocytosis of targets bearing LRP ligands but is not required for C1q-triggered enhancement of phagocytosis
    Anna P Lillis
    Center for Vascular and Inflammatory Diseases and Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 181:364-73. 2008
    ....
  73. pmc Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis
    Rie Kajino-Sakamoto
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC 27695, USA
    J Immunol 181:1143-52. 2008
    ..We propose that aberration in TAK1 signaling might disrupt intestinal homeostasis and favor the development of inflammatory disease...
  74. pmc The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression
    Chun Kim
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Nat Immunol 9:1019-27. 2008
    ..Our results suggest a dual function for p38 alpha in the regulation of inflammation and show mixed potential for its inhibition as a therapeutic strategy...
  75. pmc NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism
    Antonios O Aliprantis
    Department of Infectious Diseases and Immunology, Harvard School of Public Health, Boston, Massachusetts, USA
    J Clin Invest 118:3775-89. 2008
    ..Taken together, our study demonstrates that NFATc1 is required for remodeling of the growing and adult skeleton and suggests that NFATc1 may be an effective therapeutic target for osteoporosis associated with inflammatory states...
  76. pmc Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways
    Xiaoyu Hu
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA
    Immunity 29:691-703. 2008
    ..These findings identify new immune functions for RBP-J, Hes, and Hey proteins and provide insights into mechanisms by which Notch, TLR, and IFN-gamma signals are integrated to modulate specific effector functions in macrophages...
  77. pmc CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions
    Kyle J Eash
    Department of Medicine, Divisions of Oncology, Washington University School of Medicine, St Louis, MO, USA
    Blood 113:4711-9. 2009
    ..Collectively, these data suggest that CXCR4 signaling maintains neutrophil homeostasis in the blood under both basal and stress granulopoiesis conditions primarily by regulating neutrophil release from the bone marrow...
  78. pmc Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia
    Yitang Li
    Department of Pathology, Harvard Medical School, Dana Farber Harvard Cancer Center, Children s Hospital Boston, MA, USA
    Blood 113:4930-41. 2009
    ....
  79. pmc Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production
    Sotiria Tzima
    Biomedical Sciences Research Center Alexander Fleming, Vari 166 72, Greece
    J Exp Med 206:1167-79. 2009
    ..These results uncover a novel direct function for myeloid HO-1 in the regulation of IFN-beta production, establishing HO-1 as a critical early mediator of the innate immune response...
  80. pmc A transgenic mouse model of inducible macrophage depletion: effects of diphtheria toxin-driven lysozyme M-specific cell lineage ablation on wound inflammatory, angiogenic, and contractive processes
    Itamar Goren
    Pharmazentrum frankfurt ZAFES, Klinikum der Johann Wolfgang Goethe Universitat, Frankfurt am Main, Germany
    Am J Pathol 175:132-47. 2009
    ..promoter-driven, Cre-mediated excision of a transcriptional STOP cassette from the simian DT receptor gene in mice (lysM-Cre/DTR)...
  81. pmc Origin of the lamina propria dendritic cell network
    Milena Bogunovic
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Immunity 31:513-25. 2009
    ..Altogether, these results underline the diverse origin of the lamina propria DC network and identify mucosal DCs that arise from pre-DCs as key sentinels of the gut immune system...
  82. pmc Absence of myeloid COX-2 attenuates acute inflammation but does not influence development of atherosclerosis in apolipoprotein E null mice
    Ajay J Narasimha
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Calif 90095, USA
    Arterioscler Thromb Vasc Biol 30:260-8. 2010
    ..The role of myeloid cell cyclooxygenase-2 (COX-2) in the progression of atherosclerosis has not been clearly defined...
  83. doi Differential roles of macrophages in diverse phases of skin repair
    Tina Lucas
    Department of Dermatology, University of Cologne, Cologne, Germany
    J Immunol 184:3964-77. 2010
    ..These results demonstrate that macrophages exert distinct functions during the diverse phases of skin repair, which are crucial to control the natural sequence of repair events...
  84. pmc SOCS3 regulates graft-versus-host disease
    Geoffrey R Hill
    The Queensland Institute of Medical Research, 300 Herston Rd, Brisbane, Queensland 4006, Australia
    Blood 116:287-96. 2010
    ..Thus, the delivery of small molecule SOCS3 mimetics may prove to be useful for the inhibition of both acute and chronic GVHD...
  85. doi Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptor
    Molly M McFarland-Mancini
    Department of Cancer and Cell Biology, Vontz Center for Molecular Studies, University of Cincinnati, Cincinnati, OH 45267, USA
    J Immunol 184:7219-28. 2010
    ..These findings underscore a deeper complexity for IL-6Ralpha function in inflammation than has been recognized previously...
  86. pmc CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow
    Kyle J Eash
    Division of Oncology, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Clin Invest 120:2423-31. 2010
    ..Collectively, these data suggest that CXCR2 signaling is a second chemokine axis that interacts antagonistically with CXCR4 to regulate neutrophil release from the bone marrow...
  87. pmc Phosphoinositide-dependent kinase 1 provides negative feedback inhibition to Toll-like receptor-mediated NF-kappaB activation in macrophages
    Bhagirath Chaurasia
    Institute for Genetics, Department of Mouse Genetics and Metabolism, University of Cologne, Cologne, Germany
    Mol Cell Biol 30:4354-66. 2010
    ..These experiments reveal a novel PDK-1-dependent negative feedback inhibition of TLR-induced NF-kappaB activation in macrophages in vivo...
  88. pmc Microglial/macrophage GRK2 determines duration of peripheral IL-1beta-induced hyperalgesia: contribution of spinal cord CX3CR1, p38 and IL-1 signaling
    Hanneke L D M Willemen
    Laboratory of Neuroimmunology and Developmental Origins of Disease, University Medical Center Utrecht, 3584 EA Utrecht, The Netherlands
    Pain 150:550-60. 2010
    ..Next, we applied CRE-Lox technology to create mice with low GRK2 in microglia/macrophages/granulocytes (LysM-GRK2(f/+)), or sensory neurons or astrocytes...
  89. pmc Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress
    Thaddeus T Schug
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Mol Cell Biol 30:4712-21. 2010
    ....
  90. doi Myeloid type I interferon signaling promotes atherosclerosis by stimulating macrophage recruitment to lesions
    Pieter Goossens
    Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, 6200 MD Maastricht, The Netherlands
    Cell Metab 12:142-53. 2010
    ..Finally, we show that type I IFN signaling is upregulated in ruptured human atherosclerotic plaques. Hereby, we identify type I IFNs as proatherosclerotic cytokines that may serve as additional targets for prevention or treatment...
  91. pmc Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice
    Michael G Usher
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109 5622, USA
    J Clin Invest 120:3350-64. 2010
    ..Furthermore, myeloid MR is critical for blood pressure control and for hypertrophic and fibrotic responses in the mouse heart and aorta...
  92. pmc Cox-2 deletion in myeloid and endothelial cells, but not in epithelial cells, exacerbates murine colitis
    Tomo o Ishikawa
    Department of Molecular and Medical Pharmacology, Department of Biological Chemistry, Molecular Biology Institute, and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Carcinogenesis 32:417-26. 2011
    ..These results suggest that COX-2 expression in myeloid cells and endothelial cells, but not epithelial cells, is important for protection of epithelial cells in this murine colitis model...
  93. pmc Krüppel-like factor 4 regulates macrophage polarization
    Xudong Liao
    Case Cardiovascular Research Institute, Department of Medicine, Harrington McLaughlin Heart and Vascular Institute, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA
    J Clin Invest 121:2736-49. 2011
    ..Collectively, these data identify KLF4 as what we believe to be a novel regulator of macrophage polarization...
  94. doi A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis
    Mourad Matmati
    Department for Molecular Biomedical Research, Unit of Molecular Signal Transduction in Inflammation, Vlaams Instituut voor Biotechnologie, Ghent, Belgium
    Nat Genet 43:908-12. 2011
    ..Together, these observations indicate a critical and cell-specific function for A20 in the etiology of rheumatoid arthritis, supporting the idea of developing A20 modulatory drugs as cell-targeted therapies...
  95. pmc Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine
    Kanako L Lewis
    Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA
    Immunity 35:780-91. 2011
    ..Thus, Notch2 is a common differentiation signal for T cell-priming CD11b(+) DC subsets in the spleen and intestine...
  96. pmc Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis
    Khoa D Nguyen
    Immunology Program, Stanford University, Palo Alto, California 94305, USA
    Nature 480:104-8. 2011
    ..Thus, we have discovered a role for alternatively activated macrophages in the orchestration of an important mammalian stress response, the response to cold...
  97. pmc TAK1 negatively regulates NF-κB and p38 MAP kinase activation in Gr-1+CD11b+ neutrophils
    Adebusola Alagbala Ajibade
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
    Immunity 36:43-54. 2012
    ..Our findings identify a previously unrecognized role of TAK1 as a negative regulator of p38 and IKK activation in a cell type-specific manner...
  98. pmc Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation
    Gonghua Huang
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Immunol 13:152-61. 2012
    ..Our results identify p38α signaling as a central pathway for the integration of instructive signals in DCs for T(H)17 differentiation and inflammation...
  99. pmc TREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis
    Karel Otero
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 188:2612-21. 2012
    ..These results reveal that TREM2 regulates the rate of osteoclastogenesis and provide a mechanism for the bone pathology in NHD...
  100. doi Cutting edge: Inhibition of IL-6 trans-signaling protects from malaria-induced lethality in mice
    Claudia M Wunderlich
    Center of Molecular Medicine Cologne, Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, Institute for Genetics Cologne, Max Planck Institute for Neurological Research Cologne, D 50931 Cologne, Germany
    J Immunol 188:4141-4. 2012
    ..Therefore, inhibition of IL-6 trans-signaling may serve as a novel promising therapeutic basis to combat malaria...
  101. pmc Myeloid cell-derived hypoxia-inducible factor attenuates inflammation in unilateral ureteral obstruction-induced kidney injury
    Hanako Kobayashi
    Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    J Immunol 188:5106-15. 2012
    ..Collectively, we provide experimental evidence that hypoxia and/or myeloid cell-specific HIF activation attenuates renal inflammation associated with chronic kidney injury...

Research Grants17

  1. DYSGENIC KIDNEY LETHAL MUTANT MICE
    Jerry Lingrel; Fiscal Year: 2003
    ..These studies will lead to an understanding of how the functions of new genes affect kidney development and provide an insight into the process of nephrogenesis. ..
  2. Gene Targeting to Study Light-induced Circadian Changes
    James Waschek; Fiscal Year: 2003
    ..Moreover, the same targeting system should have utility in investigating individual components of the clock, such as PER, CRY, BMAL and CLOCK proteins. ..
  3. FUNCTIONAL STUDIES OF THE NA,K-ATPASE
    Jerry Lingrel; Fiscal Year: 2009
    ..These matings will provide animals where the alpha2 isoform is missing only in heart or smooth muscle and this will allow us to study the specific role of this isoform in cardiovascular function. ..
  4. Studies of the Lung Kruppel-Like Transcription Factor
    Jerry Lingrel; Fiscal Year: 2004
    ..We will use gene microarray analysis of cells with and without the LKLF gene and develop conditional expression of LKLF to define downstream target genes in tissues such as lung, macrophages and T-lymphocytes. ..
  5. The Role of the KLF2 in Vascular Endothelial Cells
    Jerry B Lingrel; Fiscal Year: 2010
    ..Importantly, they will serve as a prerequisite for further investigation of KLF2 as a vaso-protective therapeutic target. ..
  6. Regulation of Neural Precursors: Role of Neuropeptides
    James Waschek; Fiscal Year: 2006
    ..The work may lead to new strategies for the diagnosis and treatment of diseases of brain development, degenerative diseases and brain tumors. ..
  7. PKA modulation of hedgehog: a mouse medulloblastoma model
    James Waschek; Fiscal Year: 2009
    ..abstract_text> ..
  8. THE ROLE OF INFLAMMATION IN ANEMIA OF THE ELDERLY
    Tomas Ganz; Fiscal Year: 2010
    ..This study is designed to find how inflammation causes anemia in the elderly and how the disease processes are changed by available treatments. ..
  9. Retrocyclins: Circular Defensins Active Against HIV-1
    Alexander M Cole; Fiscal Year: 2010
    ..Availability of such agents, in the form of a cream or gel, would empower vulnerable sexual partners by providing them with an invisible, effective means of protection. ..
  10. Nasal carriage of S. aureus: host-pathogen interactions
    Alexander M Cole; Fiscal Year: 2010
    ..abstract_text> ..
  11. The impact of PPAR-gamma and estrogen receptor crosstalk on insulin action
    Andrea Hevener; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  12. The role of hemojuvelin in the regulation of iron metabolism
    Tomas Ganz; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  13. PI3K in LPS-induced coagulation and inflammation
    James Luyendyk; Fiscal Year: 2006
    ..Ultimately, characterization of the involvement of this pathway in LPS-induced inflammation may allow for development of novel strategies that can be used to treat sepsis. [unreadable] [unreadable] [unreadable]..
  14. The Role of PPAR-gamma Expression on Insulin Action
    Andrea Hevener; Fiscal Year: 2006
    ..Findings from these proposed studies will provide critical information to improve our mechanistic understanding and treatment of insulin resistance and diabetes. ..
  15. Proteomics of Staphylococcus aureus nasal carriage
    Alexander Cole; Fiscal Year: 2003
    ....
  16. INNATE HOST DEFENSE IN THE HUMAN VAGINA
    Tomas Ganz; Fiscal Year: 2004
    ..abstract_text> ..
  17. Human Defensins in Phagocytes and Epithelia
    Tomas Ganz; Fiscal Year: 2004
    ..In the aggregate, these studies will expand our understanding of is ubiquitous and multifunctional family of human host defense peptides, this time also in their role as effectors of innate immunity in epithelia. ..