Lyn

Summary

Gene Symbol: Lyn
Description: LYN proto-oncogene, Src family tyrosine kinase
Alias: AA407514, Hck-2, p53Lyn, p56Lyn, tyrosine-protein kinase Lyn, V-yes-1 Yamaguchi sarcoma viral related oncogene homolog, Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
Species: mouse

Top Publications

  1. ncbi Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice
    H Nishizumi
    Department of Oncology, Institute of Medical Science, University of Tokyo, Japan
    Immunity 3:549-60. 1995
  2. ncbi Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease
    M L Hibbs
    Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Royal Melbourne Hospital, Victoria, Australia
    Cell 83:301-11. 1995
  3. ncbi Affinity maturation in Lyn kinase-deficient mice with defective germinal center formation
    J Kato
    Department of Molecular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Immunol 160:4788-95. 1998
  4. ncbi Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes
    V W Chan
    George Williams Hooper Foundation, University of California, San Francisco 94143, USA
    Curr Biol 8:545-53. 1998
  5. pmc Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role
    Alec A Schmaier
    Department of Medicine, Division of Cardiology, Division of Hematology, Institute for Medicine and Engineering, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 106:21167-72. 2009
  6. pmc Lyn- and PLC-beta3-dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemia-like disease
    Wenbin Xiao
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Blood 116:6003-13. 2010
  7. pmc E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin alphaLbeta2-mediated slow leukocyte rolling
    Tadayuki Yago
    Cardiovascular Biology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Blood 116:485-94. 2010
  8. pmc PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling
    Alexander Zarbock
    Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    J Exp Med 205:2339-47. 2008
  9. pmc Lyn, PKC-delta, SHIP-1 interactions regulate GPVI-mediated platelet-dense granule secretion
    Ramya Chari
    Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Blood 114:3056-63. 2009
  10. pmc Lyn and PECAM-1 function as interdependent inhibitors of platelet aggregation
    Zhangyin Ming
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, USA
    Blood 117:3903-6. 2011

Research Grants

  1. Thrombopoietin Signaling: The Role of Src Kinases
    BRIAN LANNUTTI; Fiscal Year: 2007
  2. Effect of aging on lymphoid stem cells
    David Allman; Fiscal Year: 2002
  3. ONTOGENY OF PLASMACYTOID DENDRITIC CELLS
    David Allman; Fiscal Year: 2003
  4. Development of plasmacytoid dendritic cells
    David Allman; Fiscal Year: 2008
  5. Aging of Early B Cell Precursors
    David M Allman; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications129 found, 100 shown here

  1. ncbi Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice
    H Nishizumi
    Department of Oncology, Institute of Medical Science, University of Tokyo, Japan
    Immunity 3:549-60. 1995
    The Src family protein-tyrosine kinase Lyn associates physically with the BCR and has been suggested to play an important role in BCR-mediated signaling...
  2. ncbi Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease
    M L Hibbs
    Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Royal Melbourne Hospital, Victoria, Australia
    Cell 83:301-11. 1995
    Mice homozygous for a disruption at the Lyn locus display abnormalities associated with the B lymphocyte lineage and in mast cell function...
  3. ncbi Affinity maturation in Lyn kinase-deficient mice with defective germinal center formation
    J Kato
    Department of Molecular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Immunol 160:4788-95. 1998
    b>Lyn kinase-deficient (lyn-/-) mice show several abnormalities such as reduced numbers of circulating B cells, hyper-IgM, and low proliferative responses induced by CD40 ligand...
  4. ncbi Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes
    V W Chan
    George Williams Hooper Foundation, University of California, San Francisco 94143, USA
    Curr Biol 8:545-53. 1998
    To elucidate the role of the Src family kinase Lyn in B cell receptor (BCR) signaling, we and others previously generated lyn-/- mice and analyzed their B cell responses...
  5. pmc Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role
    Alec A Schmaier
    Department of Medicine, Division of Cardiology, Division of Hematology, Institute for Medicine and Engineering, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 106:21167-72. 2009
    ..The GPVI PRD specifically binds the Src-family kinase Lyn and directly activates it, presumably through SH3 displacement...
  6. pmc Lyn- and PLC-beta3-dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemia-like disease
    Wenbin Xiao
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Blood 116:6003-13. 2010
    ..Thus, PLC-β3-deficient mice develop myeloproliferative neoplasm, like Lyn (Src family kinase)- deficient mice...
  7. pmc E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin alphaLbeta2-mediated slow leukocyte rolling
    Tadayuki Yago
    Cardiovascular Biology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Blood 116:485-94. 2010
    ..of PSGL-1 or CD44 triggered slow rolling through a common, lipid raft-dependent pathway that used the SFKs Hck and Lyn as well as Fgr...
  8. pmc PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling
    Alexander Zarbock
    Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    J Exp Med 205:2339-47. 2008
    ..E-selectin-mediated phosphorylation of Syk and slow rolling was abolished in neutrophils from fgr(-/-) or hck(-/-) lyn(-/-) fgr(-/-) mice...
  9. pmc Lyn, PKC-delta, SHIP-1 interactions regulate GPVI-mediated platelet-dense granule secretion
    Ramya Chari
    Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Blood 114:3056-63. 2009
    ..b>Lyn and SHIP-1, but not SHIP-2 or Shc, preferentially associated with PKC-delta on stimulation of platelets with a GPVI ..
  10. pmc Lyn and PECAM-1 function as interdependent inhibitors of platelet aggregation
    Zhangyin Ming
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI, USA
    Blood 117:3903-6. 2011
    ..Platelet-endothelial cell adhesion molecule-1 (PECAM-1) and the Src family kinase Lyn inhibit platelet activation by the glycoprotein VI (GPVI) collagen receptor; however, it is not known whether PECAM-..
  11. pmc Phospholipase C-β3 regulates FcɛRI-mediated mast cell activation by recruiting the protein phosphatase SHP-1
    Wenbin Xiao
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Immunity 34:893-904. 2011
    ..in Plcb3(-/-) cells could be accounted for by increased activity of the negative regulatory Src family kinase Lyn and reduced activities of the positive regulatory protein kinases MAPKs...
  12. doi Lyn kinase controls TLR4-dependent IKK and MAPK activation modulating the activity of TRAF-6/TAK-1 protein complex in mast cells
    Martin Avila
    Centro de Investigación y de Estudios Avanzados Cinvestav, Mexico City, Mexico
    Innate Immun 18:648-60. 2012
    ..The tyrosine kinase Lyn is important to the high affinity IgE receptor (FcεRI) signal transduction system in MCs, but its role on the TLR4 ..
  13. pmc Signal-dependent slow leukocyte rolling does not require cytoskeletal anchorage of P-selectin glycoprotein ligand-1 (PSGL-1) or integrin αLβ2
    Bojing Shao
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 287:19585-98. 2012
    ..The cytoskeletal independence of PSGL-1-initiated, α(L)β(2)-mediated slow rolling differs markedly from the cytoskeletal dependence of chemokine-initiated, α(L)β(2)-mediated arrest...
  14. ncbi Fer and Fps/Fes participate in a Lyn-dependent pathway from FcepsilonRI to platelet-endothelial cell adhesion molecule 1 to limit mast cell activation
    Christian M Udell
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada
    J Biol Chem 281:20949-57. 2006
    ..activities and that Fer phosphorylation downstream of FcepsilonRI is independent of Syk, Fyn, and Gab2 but requires Lyn. Activated Fer/Fps readily phosphorylate the C terminus of platelet-endothelial cell adhesion molecule 1 (Pecam-1) ..
  15. pmc ST6Gal-I restrains CD22-dependent antigen receptor endocytosis and Shp-1 recruitment in normal and pathogenic immune signaling
    Prabhjit K Grewal
    Department of Cellular and Molecular Medicine and Howard Hughes Medical Institute, 9500 Gilman Drive MC0625, University of California San Diego, La Jolla, CA 92093, USA
    Mol Cell Biol 26:4970-81. 2006
    ..deficiency further correlate with constitutive recruitment of Shp-1 to CD22 in unstimulated B cells independent of Lyn tyrosine kinase activity and prevent autoimmune disease pathogenesis in the Lyn-deficient model of systemic lupus ..
  16. pmc Btk regulates multiple stages in the development and survival of B-1 cells
    Cristina M Contreras
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Mol Immunol 44:2719-28. 2007
    ..Multiple roles for Btk in B-1 cell development and maintenance may explain the particular sensitivity of this population to mutations in components of Btk signaling pathways...
  17. pmc Binding of laminin-1 to monosialoganglioside GM1 in lipid rafts is crucial for neurite outgrowth
    Naoki Ichikawa
    Research Institute for Diseases of Old Age, Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    J Cell Sci 122:289-99. 2009
    ..and enrichment of beta1 integrin in lipid rafts--where TrkA colocalizes with beta1 integrin--and the activation of Lyn, Akt and MAPK to promote the outgrowth of neurites...
  18. pmc Physical and functional association of the cbl protooncogen product with an src-family protein tyrosine kinase, p53/56lyn, in the B cell antigen receptor-mediated signaling
    T Tezuka
    Department of Oncology, Institute of Medical Science, University of Tokyo, Japan
    J Exp Med 183:675-80. 1996
    ..tyrosine kinases (PTKs), we used a yeast two-hybrid system with a probe corresponding to the regulatory region of p56lyn, a member of Src-family PTKs...
  19. ncbi Critical role for the tyrosine kinase Syk in signalling through the high affinity IgE receptor of mast cells
    P S Costello
    National Institute for Medical Research, London, UK
    Oncogene 13:2595-605. 1996
    ..strongly supports a model of Fc epsilon RI engagement leading to the sequential activation of the tyrosine kinases Lyn and then Syk...
  20. ncbi Impaired tyrosine phosphorylation and Ca2+ mobilization, but not degranulation, in lyn-deficient bone marrow-derived mast cells
    H Nishizumi
    Department of Oncology, Institute of Medical Science, University of Tokyo, Japan
    J Immunol 158:2350-5. 1997
    ..Fc epsilon RI associates with two classes of the tyrosine kinases, the Src family kinases, such as Lyn, c-Yes, and c-Src, and the Syk kinase...
  21. pmc Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice
    J Wang
    Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Exp Med 184:831-8. 1996
    Mice deficient in the src related protein tyrosine kinase, Lyn, exhibit splenomegaly and accumulate lymphoblast-like and plasma cells in spleen as they age, resulting in elevated levels of serum IgM (10-20-fold of control) and ..
  22. pmc Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn
    F Meng
    Department of Laboratory Medicine, University of California, San Francisco 94143 0724, USA
    J Exp Med 185:1661-70. 1997
    ..amount of evidence suggests that protein tyrosine kinases especially the Src-family kinases Hck, Fgr, and Lyn, play important roles in LPS signaling...
  23. ncbi Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation
    V W Chan
    Department of Biochemistry and Biophysics, George Williams Hooper Foundation, University of California, San Francisco 94143, USA
    Immunity 7:69-81. 1997
    b>Lyn-deficient mice were generated to analyze the role of Lyn in B cell antigen receptor (BCR) signaling...
  24. pmc A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages
    M T Crowley
    G W Hooper Foundation, University of California, San Francisco, California 94143 0552, USA
    J Exp Med 186:1027-39. 1997
    ..from mice deficient for the three members of the Src-family of kinases expressed in these cells, Hck, Fgr, and Lyn, exhibited poor Syk activation upon FcgammaR engagement, accompanied by a delay in FcgammaR-mediated phagocytosis...
  25. pmc Inhibition of the B cell by CD22: a requirement for Lyn
    K G Smith
    Wellcome Trust Immunology Unit, Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, England CB2 2SP
    J Exp Med 187:807-11. 1998
    Mice in which the Lyn, Cd22, or Shp-1 gene has been disrupted have hyperactive B cells and autoantibodies...
  26. pmc A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration
    F Meng
    Department of Laboratory Medicine, University of California at San Francisco 94143 0100, USA
    EMBO J 17:4391-403. 1998
    ..Cbl) protein rapidly becomes tyrosine phosphorylated and associated with the Src-family kinases Fgr and Lyn. In hck-/-fgr-/-lyn-/- triple mutant cells, which are defective in spreading on fibronectin-coated surfaces in ..
  27. ncbi Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase
    S Hunter
    Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 274:2097-106. 1999
    ..GST) fusion proteins encoding the unique, Src homology domain 3 (SH3), and SH2 domains of Fyn, Hck, or Lyn. Fusion proteins encoding either the SH3 or SH2 domains of Fyn bound to Cbl as effectively as the fusion protein ..
  28. ncbi Genetic analysis of B cell antigen receptor signaling
    T Kurosaki
    Department of Molecular Genetics, Kansai Medical University, Moriguchi, Japan
    Annu Rev Immunol 17:555-92. 1999
    ..experiments in cell lines and mice have revealed distinct functions for the intracellular protein tyrosine kinases (Lyn, Syk, Btk) in BCR signaling and B cell development...
  29. ncbi Genetic evidence for Lyn as a negative regulator of IL-4 signaling
    M L Janas
    The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    J Immunol 163:4192-8. 1999
    ..In this report we describe a critical role for the tyrosine kinase Lyn in setting IL-4 signaling thresholds in mouse B lymphocytes...
  30. pmc Constitutive tyrosine phosphorylation of the inhibitory paired Ig-like receptor PIR-B
    L H Ho
    Division of Developmental Immunology, University of Alabama at Birmingham, Birmingham, AL 35294 3300, USA
    Proc Natl Acad Sci U S A 96:15086-90. 1999
    ..Splenocyte PIR-B molecules were constitutively associated with the SHP-1 protein tyrosine phosphatase and Lyn protein tyrosine kinase. In Lyn-deficient mice, PIR-B tyrosine phosphorylation was greatly reduced...
  31. pmc Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn
    C J Fitzer-Attas
    Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, California 94143, USA
    J Exp Med 191:669-82. 2000
    ..macrophages from mutant mice lacking the major Src family kinases expressed in these cells, Hck, Fgr, and Lyn. Many FcgammaR-induced functional responses and signaling events were diminished or delayed in these macrophages, ..
  32. ncbi Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation
    Y Kawakami
    Division of Allergy, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 165:1210-9. 2000
    ..on growth properties and FcepsilonRI-mediated signal transduction of primary cultured mast cells from Btk-, Lyn-, and Btk/Lyn-deficient mice. First, Lyn deficiency partially reversed the survival effect of Btk deficiency...
  33. ncbi Lupus-like kidney disease in mice deficient in the Src family tyrosine kinases Lyn and Fyn
    C C Yu
    G W Hooper Foundation, University of California, San Francisco, CA 94143, USA
    Curr Biol 11:34-8. 2001
    ..We [2] and others [3, 4] previously demonstrated that mice deficient in the Src family tyrosine kinase Lyn developed a mild lupus-like disease with high survival rates...
  34. ncbi Resting murine neutrophils express functional alpha 4 integrins that signal through Src family kinases
    S Pereira
    Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA
    J Immunol 166:4115-23. 2001
    ..Neutrophils derived from hck(-/-)fgr(-/-)lyn(-/-) triple-knockout or hck(-/-)fgr(-/-) double-knockout mice failed to undergo respiratory burst when plated on ..
  35. ncbi Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage
    K W Harder
    Ludwig Institute for Cancer Research, Melbourne Tumor Biology Branch, Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia
    Immunity 15:603-15. 2001
    To investigate the role of the Lyn kinase in establishing signaling thresholds in hematopoietic cells, a gain-of-function mutation analogous to the Src Y527F-activating mutation was introduced into the Lyn gene...
  36. ncbi Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation
    D Allman
    Department of Pathology and Laboratory Medicine and Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 167:6834-40. 2001
    ..This contrasts markedly with lyn(-/-) mice, which exhibit depressed numbers but normal ratios of each immature peripheral B cell subset and severely ..
  37. pmc Gab3, a new DOS/Gab family member, facilitates macrophage differentiation
    Ingrid Wolf
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Mol Cell Biol 22:231-44. 2002
    ..These results suggest that Gab3 is important for macrophage differentiation and that differentiation requires the early phosphorylation of Gab2 followed by induction and subsequent phosphorylation of Gab3...
  38. ncbi Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation
    Valentino Parravicini
    Molecular Inflammation Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1820, USA
    Nat Immunol 3:741-8. 2002
    Fc epsilon RI activation of mast cells is thought to involve Lyn and Syk kinases proximal to the receptor and the signaling complex organized by the linker for activation of T cells (LAT)...
  39. ncbi Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development
    Kaoru Saijo
    Laboratory of Lymphocyte Signaling, The Rockefeller University, New York, NY 10021, USA
    Nat Immunol 4:274-9. 2003
    ..Using mice deficient for the B cell-expressed Src-family protein tyrosine kinases (SFKs) Blk, Fyn and Lyn, we show an essential role of these kinases in pre-B cell receptor (pre-BCR)- mediated NF-kappaB activation and B ..
  40. ncbi The Lyn tyrosine kinase negatively regulates neutrophil integrin signaling
    Shalini Pereira
    Department of Laboratory Medicine, University of California, San Francisco, CA 94143, USA
    J Immunol 171:1319-27. 2003
    The Src family kinase Lyn has been shown to play both stimulatory and inhibitory roles within several hemopoietic cell types. In this study, we investigated the role played by Lyn in neutrophil integrin signaling...
  41. ncbi Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells
    Valerie Hernandez-Hansen
    Department of Pathology and Cancer Research and Treatment Center, University of New Mexico School of Medicine, CRF 205, 2325 Camino de Salud, Albuquerque, NM 87131, USA
    J Immunol 173:100-12. 2004
    Studies in B cells from Lyn-deficient mice have identified Lyn as both a kinetic accelerator and negative regulator of signaling through the BCR...
  42. ncbi Perturbed myelo/erythropoiesis in Lyn-deficient mice is similar to that in mice lacking the inhibitory phosphatases SHP-1 and SHIP-1
    Kenneth W Harder
    Ludwig Institute for Cancer Research, PO Box 2008, Royal Melbourne Hospital, Melbourne, Victoria 3050, Australia
    Blood 104:3901-10. 2004
    The Lyn tyrosine kinase plays essential inhibitory signaling roles within hematopoietic cells by recruiting inhibitory phosphatases such as SH2-domain containing phosphatase-1 (SHP-1), SHP-2, and SH2-domain containing 5'-inositol ..
  43. ncbi Lyn deficiency reduces GATA-1, EKLF and STAT5, and induces extramedullary stress erythropoiesis
    Evan Ingley
    Laboratory for Cancer Medicine, Western Australian Institute for Medical Research and Centre for Medical Research, The University of Western Australia, WA, Australia
    Oncogene 24:336-43. 2005
    In vitro studies have implicated the Lyn tyrosine kinase in erythropoietin signaling. In this study, we show that J2E erythroid cells lacking Lyn have impaired signaling and reduced levels of transcription factors STAT5a, EKLF and GATA-1...
  44. ncbi Lyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunity
    Sarah Jane E Beavitt
    Lung Disease Research Group, Department of Medicine, University of Melbourne, Victoria, Australia
    J Immunol 175:1867-75. 2005
    ..b>Lyn tyrosine kinase has been implicated as both a facilitator and inhibitor of signaling pathways that play a role in ..
  45. ncbi The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation
    Ching Liang Chu
    Department of Laboratory Medicine, University of California, San Francisco, CA 94143 0134, USA
    J Immunol 175:2880-9. 2005
    The Src family kinase Lyn plays both stimulatory and inhibitory roles in hemopoietic cells. In this report we provide evidence that Lyn is involved in dendritic cell (DC) generation and maturation...
  46. pmc G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth
    Quan Sheng Zhu
    Division of Pediatrics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 107:1847-56. 2006
    ..G-CSF stimulation showed a time- and dose-dependent increase in ROS production, correlating with activation of Lyn and Akt. Inhibition of Lyn, PI3-kinase, and Akt abrogated G-CSF-induced ROS production...
  47. ncbi Impaired FcepsilonRI-dependent gene expression and defective eicosanoid and cytokine production as a consequence of Fyn deficiency in mast cells
    Gregorio Gomez
    Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 1820, USA
    J Immunol 175:7602-10. 2005
    ..These studies reveal a major positive role for Fyn kinase in multiple mast cell inflammatory responses and demonstrate a selective negative regulatory role for certain cytokines...
  48. ncbi Increased megakaryocytopoiesis in Lyn-deficient mice
    B J Lannutti
    Puget Sound Blood Center, Seattle, WA, USA
    Oncogene 25:3316-24. 2006
    Previous studies in cell lines have shown Lyn kinase to be a negative regulator of thrombopoietin (TPO)-induced proliferation...
  49. ncbi Mutation of the Lyn tyrosine kinase delays the progression of Friend virus induced erythroleukemia without affecting susceptibility
    Aparna Subramanian
    Graduate Program in Biochemistry, Microbiology and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA
    Leuk Res 30:1141-9. 2006
    ..In particular, mutation of Src and Lyn can affect erythropoiesis...
  50. pmc Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs
    Attila Mocsai
    Department of Physiology, Semmelweis University School of Medicine, 1088 Budapest, Hungary
    Nat Immunol 7:1326-33. 2006
    ..Our data show that integrin signaling for the activation of cellular responses in neutrophils and macrophages proceeds by an immunoreceptor-like mechanism...
  51. ncbi MyD88-dependent autoimmune disease in Lyn-deficient mice
    Karlee L Silver
    Henry Wellcome Building of Molecular Physiology, University of Oxford, Oxford, UK
    Eur J Immunol 37:2734-43. 2007
    ..To address this, we have examined the role of TLR signaling in Lyn-deficient mice, which develop an autoimmune disease similar to SLE...
  52. pmc Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5
    Wenbin Xiao
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
    J Clin Invest 118:924-34. 2008
    ..Here we have shown that, similar to mice deficient in the lipid phosphatase SHIP, loss of 2 Src family kinases, Lyn and Hck, profoundly affects HSC differentiation, producing hematopoietic progenitors with increased proliferation, ..
  53. ncbi Cholesterol-rich membrane rafts and Lyn are involved in phagocytosis during Pseudomonas aeruginosa infection
    Shibichakravarthy Kannan
    Department of Biochemistry and Molecular Biology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58203, USA
    J Immunol 180:2396-408. 2008
    ..pathway for Pseudomonas aeruginosa, which is initiated by cholesterol-rich membrane rafts and is dependent on Lyn, primarily an immune regulator with both positive and negative roles...
  54. doi A kinase-dead allele of Lyn attenuates autoimmune disease normally associated with Lyn deficiency
    Anne M Verhagen
    Signal Transduction Laboratory, St Vincent s Institute, Fitzroy, Victoria, Australia
    J Immunol 182:2020-9. 2009
    b>Lyn kinase, a member of the Src family of tyrosine kinases, functions as both a positive and negative regulator of B cell activation...
  55. pmc Critical role of phospholipase Cgamma2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis
    Zoltan Jakus
    Department of Physiology, Semmelweis University School of Medicine, 1094 Budapest, Hungary
    J Exp Med 206:577-93. 2009
    ..These results identify PLCgamma2 as a critical player of integrin and Fc receptor-mediated neutrophil functions and the neutrophil-mediated effector phase of autoimmune arthritis...
  56. pmc Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation
    Nicolas Charles
    Laboratory of Immune Cell Signaling, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 30:533-43. 2009
    ..Here, we demonstrate that Lyn kinase dampened basophil expression of the transcription factor GATA-3 and the initiation and extent of Th2 cell ..
  57. pmc Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance
    Andrew J Gross
    Department of Medicine, University of California, San Francisco, CA 94143, USA
    J Immunol 182:5382-92. 2009
    To better understand whether autoimmunity in Lyn-deficient mice arises from compromised central or peripheral B cell tolerance, we examined BCR signaling properties of wild-type and Lyn-deficient B cells at different stages of ..
  58. pmc The caspase-cleaved form of LYN mediates a psoriasis-like inflammatory syndrome in mice
    Sandrine Marchetti
    INSERM, U895, Centre Méditerranéen de Médecine Moléculaire C3M, Team 2, Nice, France
    EMBO J 28:2449-60. 2009
    We showed previously that Lyn is a substrate for caspases, a family of cysteine proteases, involved in the regulation of apoptosis and inflammation...
  59. pmc Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases
    Marina Tiemi Shio
    Department of Medicine, Microbiology and Immunology, Centre for the Study of Host Resistance, The Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
    PLoS Pathog 5:e1000559. 2009
    ..We further demonstrate, using pharmacological and genetic intervention, that the tyrosine kinases Syk and Lyn play a critical role in activation of this inflammasome...
  60. doi Autoimmune disease in Lyn-deficient mice is dependent on an inflammatory environment established by IL-6
    Evelyn Tsantikos
    Signal Transduction Laboratory, Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria, Australia
    J Immunol 184:1348-60. 2010
    b>Lyn-deficient mice develop Ab-mediated autoimmune disease resembling systemic lupus erythematosus where hyperactive B cells are major contributors to pathology...
  61. pmc Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis
    Yves T Falanga
    Department of Biology, Virginia Commonwealth University, Richmond, VA 23284, USA
    J Immunol 188:4360-8. 2012
    ..We have investigated the contribution of Fyn and Lyn tyrosine kinases to FcγRIIb and FcγRIII signaling in the context of IgG-mediated passive systemic anaphylaxis (..
  62. doi MLR-1023 is a potent and selective allosteric activator of Lyn kinase in vitro that improves glucose tolerance in vivo
    Michael S Saporito
    Melior Discovery, Inc, 860 Springdale Drive, Exton, PA 19341, USA
    J Pharmacol Exp Ther 342:15-22. 2012
    ..However, in an in vitro broad kinase screen MLR-1023 activated the nonreceptor-linked Src-related tyrosine kinase Lyn. MLR-1023 increased the V(max) of Lyn with an EC(50) of 63 nM...
  63. pmc Massively parallel sequencing of the mouse exome to accurately identify rare, induced mutations: an immediate source for thousands of new mouse models
    T D Andrews
    Immunogenomics Laboratory, Australian National University, GPO Box 334, Canberra City, Australian Capital Territory, 2601, Australia
    Open Biol 2:120061. 2012
    ..This approach transforms genetic screens in mice, establishes a general strategy for analysing rare DNA variants and opens up a large new source for experimental models of human disease...
  64. pmc A double-edged kinase Lyn: a positive and negative regulator for antigen receptor-mediated signals
    H Nishizumi
    Department of Oncology, Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
    J Exp Med 187:1343-8. 1998
    B cells from young lyn-/- mice are hyperresponsive to anti-IgM-induced proliferation, suggesting involvement of Lyn in negative regulation of B cell antigen receptor (BCR)-mediated signaling...
  65. ncbi Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection
    R J Cornall
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University, Palo Alto, California 94305, USA
    Immunity 8:497-508. 1998
    ..hyperactivity syndrome resembling systemic lupus erythematosus characterizes mice lacking the src-family kinase Lyn. Lyn is not required to initiate B cell antigen receptor (BCR) signaling but is an essential inhibitory component...
  66. ncbi The inositol 5'-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity
    Christopher P Baran
    Dorothy M Davis Heart and Lung Research Institute, Ohio State University, Columbus 43210, USA
    J Biol Chem 278:38628-36. 2003
    ..In THP-1 cells, SHIP-1 bound Lyn, independent of the kinase activity of Lyn, following M-CSF activation...
  67. ncbi Lyn tyrosine kinase: accentuating the positive and the negative
    Yuekang Xu
    The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    Immunity 22:9-18. 2005
    b>Lyn, one of several Src-family tyrosine kinases in immune cells, is noted for its ability to negatively regulate signaling pathways through phosphorylation of inhibitory receptors, enzymes, and adaptors...
  68. ncbi Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy
    Junichi Hirahashi
    Department of Pathology, Center for Excellence in Vascular Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 25:271-83. 2006
    ..These data suggest that Mac-1 engagement of complement activates tyrosine kinases to promote elastase-dependent blood vessel injury in vivo...
  69. pmc CD19 signaling is impaired in murine peritoneal and splenic B-1 B lymphocytes
    Trivikram Dasu
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, 40536 0298, United States
    Mol Immunol 46:2655-65. 2009
    ..These findings suggest a defect in CD19-mediated signals in both peritoneal and splenic B-1 B lymphocytes, which is in part, due to higher levels of constitutively active Lyn.
  70. pmc Proline-rich sequences that bind to Src homology 3 domains with individual specificities
    K Alexandropoulos
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Proc Natl Acad Sci U S A 92:3110-4. 1995
    ..The SH3 domains of the Src-related kinases Fyn, Lyn, and Hck bind to this sequence with the same affinity as that of the Src SH3...
  71. ncbi Lyn, a src-like tyrosine kinase
    M L Hibbs
    Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch, Royal Melbourne Hospital, Victoria, Australia
    Int J Biochem Cell Biol 29:397-400. 1997
    b>Lyn is a member of the src family of non-receptor protein tyrosine kinases that is predominantly expressed in haematopoietic tissues...
  72. ncbi Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway
    L S Quek
    Department of Pharmacology, University of Oxford, United Kingdom
    Blood 96:4246-53. 2000
    ..In the current study, the role of 2 Src family kinases, Fyn and Lyn, in GPVI signaling has been examined using murine platelets deficient in one or both kinases...
  73. ncbi Novel roles for Lyn in B cell migration and lipopolysaccharide responsiveness revealed using anti-double-stranded DNA Ig transgenic mice
    S Seo
    The Wistar Institute, Philadelphia, PA 19104, USA
    J Immunol 166:3710-6. 2001
    b>Lyn-deficient mice produce Abs against dsDNA, yet exhibit exaggerated tolerance to the model Ag hen-egg lysozyme...
  74. ncbi Rapid and large amount of autocrine IL-3 production is responsible for mast cell survival by IgE in the absence of antigen
    Masayuki Kohno
    Department of Molecular Genetics, Graduate School of Medicine, Chiba University, Chiba, Japan
    Blood 105:2059-65. 2005
    ..b>Lyn and Syk were essential, whereas Fyn, Gab2, and the phosphoinositide 3-kinase-Akt pathway were not critical for ..
  75. ncbi Abrogation of autoimmune disease in Lyn-deficient mice by the mutation of the Btk gene
    H Takeshita
    Department of Molecular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Int Immunol 10:435-44. 1998
    b>Lyn and Btk play a critical role in B cell development and intracellular signaling. Lyn-deficient mice exhibit splenomegaly, elevated serum levels of IgM, production of autoantibody and glomerulonephritis with age...
  76. pmc NMDA receptor-dependent regulation of axonal and dendritic branching
    Li Jen Lee
    Department of Cell Biology and Anatomy, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Neurosci 25:2304-11. 2005
    ..These results indicate that NMDARs regulate growth of presynaptic terminal arbors and postsynaptic dendritic branching, thereby leading to consolidation of synapses and patterning of presynaptic and postsynaptic elements...
  77. pmc Recombinant inbred strain and interspecific backcross analysis of molecular markers flanking the murine agouti coat color locus
    L D Siracusa
    Mammalian Genetics Laboratory, NCI Frederick Cancer Research Facility, Maryland 21701
    Genetics 122:669-79. 1989
    ..The Psp-2 locus maps to mouse chromosome 14. The Hck-2 locus maps near the centromere of mouse chromosome 4 and may identify the Lyn locus. The Hck-3 locus maps near the distal end of mouse chromosome 4 and may identify the Lck locus.
  78. ncbi Peptidoglycan induces transcription and secretion of TNF-alpha and activation of lyn, extracellular signal-regulated kinase, and rsk signal transduction proteins in mouse macrophages
    D Gupta
    Northwest Center for Medical Education, Indiana University School of Medicine, Gary 46408, USA
    J Immunol 155:2620-30. 1995
    ..PGN and sPGN also induced rapid and dose-dependent tyrosine phosphorylation of several cellular proteins, including lyn and mitogen-activated protein kinases (extracellular signal-regulated kinases; but not hck, fgr, or vav) and ..
  79. ncbi Expression of tyrosine kinase gene in mouse thymic stromal cells
    T F Rinke De Wit
    Department of Immunology, Erasmus University Rotterdam, The Netherlands
    Int Immunol 8:1787-95. 1996
    ..These data provide the first example of a receptor PTK in TSC and open new approaches to study the regulation of TSC differentiation...
  80. ncbi Role of Src kinases and Syk in Fcgamma receptor-mediated phagocytosis and phagosome-lysosome fusion
    M Majeed
    Department of Pathology, Section of General Pathology, University of Verona, Verona, Italy
    J Leukoc Biol 70:801-11. 2001
    ..Similar studies with macrophages lacking the Src family kinases Hck, Fgr, and Lyn showed that these kinases are not required for phagocytosis but that they enhance the rate of particle engulfment...
  81. ncbi Role of the Src family kinase Lyn in TxA2 production, adenosine diphosphate secretion, Akt phosphorylation, and irreversible aggregation in platelets stimulated with gamma-thrombin
    Moon J Cho
    Department of Microbiology and Molecular Cell Sciences, University of Memphis, Memphis, TN 38152, USA
    Blood 99:2442-7. 2002
    ..Although their localization is known, their role(s) in platelet function are not well understood. Lyn is a Src-family kinase that participates in signal transduction pathways elicited by collagen-related peptide; it ..
  82. ncbi Sequential translocation of tyrosine kinases Lyn and Syk to the activated Fcgamma receptors during phagocytosis
    A Strzelecka-Kiliszek
    Department of Cell Biology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw
    Folia Histochem Cytobiol 40:131-2. 2002
    ..b>Lyn kinase is phosphorylated both at particle binding and internalization steps...
  83. ncbi Impairment of N-methyl-D-aspartate receptor-controlled motor activity in LYN-deficient mice
    H Umemori
    Department of Oncology, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Neuroscience 118:709-13. 2003
    ..A Src family kinase Lyn is highly expressed in striatum, cortex, thalamus, and cerebellum in the brain...
  84. ncbi G-CSF-induced tyrosine phosphorylation of Gab2 is Lyn kinase dependent and associated with enhanced Akt and differentiative, not proliferative, responses
    Quan Sheng Zhu
    Division of Pediatrics, University of Texas M D Anderson Cancer, Houston, TX 77030, USA
    Blood 103:3305-12. 2004
    ..cell proliferation, survival, and differentiation through the recruitment of nonreceptor protein tyrosine kinases Lyn and janus kinase 2 (Jak2)...
  85. ncbi Dysregulation of Src family kinases in mast cells from epilepsy-resistant ASK versus epilepsy-prone EL mice
    Jiro Kitaura
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 178:455-62. 2007
    ..Consistent with the similarities of these ASK and EL mast cell responses with phenotypes of lyn(-/-) and wild-type mast cells, respectively, Lyn activity was reduced in ASK cells...
  86. pmc The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn
    Hong Hong
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, CA 92037, USA
    Blood 110:2511-9. 2007
    ..The Src family tyrosine kinase (SFK) Lyn is activated by the cross-linking of high-affinity IgE receptors (FcepsilonRI)...
  87. pmc Src family kinase-mediated negative regulation of hematopoietic stem cell mobilization involves both intrinsic and microenvironmental factors
    Jovencio Borneo
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Exp Hematol 35:1026-37. 2007
    ..The intracellular signals that contribute to granulocyte colony-stimulating factor (G-CSF) receptor induced stem cell mobilization are poorly characterized...
  88. ncbi Cutting edge: genetic variation influences Fc epsilonRI-induced mast cell activation and allergic responses
    Yumi Yamashita
    Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 179:740-3. 2007
    ..Deficiency of the Src family kinase Lyn enhanced degranulation in 129/Sv BMMCs but inhibited this response in C57BL/6 cells...
  89. pmc Deficiency of Src family kinases compromises the repopulating ability of hematopoietic stem cells
    Christie M Orschell
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Exp Hematol 36:655-66. 2008
    ..However, little is known about the role of these kinases in the growth, homing, and engraftment potential of hematopoietic stem and progenitor cells...
  90. pmc Membrane heterogeneities in the formation of B cell receptor-Lyn kinase microclusters and the immune synapse
    Hae Won Sohn
    Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Cell Biol 182:367-79. 2008
    ..binding to the B cell receptors (BCRs) induces BCR clustering, phosphorylation of BCRs by the Src family kinase Lyn, initiation of signaling, and formation of an immune synapse...
  91. pmc A conserved salt bridge in the G loop of multiple protein kinases is important for catalysis and for in vivo Lyn function
    Rina Barouch-Bentov
    Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA
    Mol Cell 33:43-52. 2009
    ..In WeeB mice, mutational disruption of the interaction results in expression of a Lyn protein with reduced catalytic activity, and in perturbed B cell receptor signaling...
  92. pmc A minor catalytic activity of Src family kinases is sufficient for maximal activation of mast cells via the high-affinity IgE receptor
    Michael Poderycki
    Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 184:84-93. 2010
    ..b>Lyn is the predominant SFK in mast cells and has been ascribed both positive and negative roles in regulating mast cell ..
  93. pmc An important role of the SRC family kinase Lyn in stimulating platelet granule secretion
    Zhenyu Li
    Department of Pharmacology, College of Medicine, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 285:12559-70. 2010
    ..The mechanisms for these apparently contradictory roles are unclear. Here we show that SFK, mainly Lyn, is important in stimulating a common signaling pathway leading to secretion of platelet granules...
  94. pmc Separate checkpoints regulate splenic plasma cell accumulation and IgG autoantibody production in Lyn-deficient mice
    Toni Gutierrez
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Eur J Immunol 40:1897-905. 2010
    ..Mice deficient in Lyn, a negative regulator of B and myeloid cell activity, develop lupus-like autoimmune disease...
  95. pmc Negative regulation of Gq-mediated pathways in platelets by G(12/13) pathways through Fyn kinase
    Soochong Kim
    Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 286:24170-9. 2011
    ..Importantly, AYPGKF-induced platelet aggregation and PKC activation were potentiated in Fyn-deficient but not in Lyn-deficient mice compared with wild-type littermates...
  96. pmc Balanced interactions between Lyn, the p85alpha regulatory subunit of class I(A) phosphatidylinositol-3-kinase, and SHIP are essential for mast cell growth and maturation
    Peilin Ma
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W Walnut Street, Indianapolis, IN 46202, USA
    Mol Cell Biol 31:4052-62. 2011
    ..We show that the Lyn SFK and the p85α subunit of class I(A) PI3K play opposing roles in regulating the growth and maturation of BMMCs ..
  97. ncbi Specific expressions of Fyn and Lyn, lymphocyte antigen receptor-associated tyrosine kinases, in the central nervous system
    H Umemori
    Department of Oncology, University of Tokyo, Japan
    Brain Res Mol Brain Res 16:303-10. 1992
    The Src-like protein-tyrosine kinases Fyn and Lyn are expressed in lymphocytes...
  98. pmc A mammalian protein kinase with potential for serine/threonine and tyrosine phosphorylation is related to cell cycle regulators
    Y Ben-David
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    EMBO J 10:317-25. 1991
    ..These results suggest the existence of a novel class of protein kinases, with an unusual substrate specificity, which may be involved in cell cycle control...
  99. ncbi A molecular genetic linkage map of mouse chromosome 4 including the localization of several proto-oncogenes
    J D Ceci
    Mammalian Genetics Laboratory, BRI Basic Research Program, NCI Frederick Cancer Research Facility, Maryland 21701
    Genomics 5:699-709. 1989
    ..and common sites of viral integration have been assigned regional locations on chromosome 4 including Mos, Lyn, Jun, Lmyc, Lck, Fgr, and Dsi-1...
  100. pmc The molecular mechanism of B cell activation by toll-like receptor protein RP-105
    V W Chan
    Department of Laboratory Medicine, University of California, San Francisco, California 94143, USA
    J Exp Med 188:93-101. 1998
    ..Here we demonstrate that the Src-family protein tyrosine kinase Lyn, protein kinase C beta I/II (PKCbetaI/II), and Erk2-specific mitogen-activated protein (MAP) kinase kinase (MEK) ..
  101. pmc Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways
    A B Satterthwaite
    Department of Microbiology and Molecular Genetics, University of California Los Angeles 90095, USA
    J Exp Med 188:833-44. 1998
    ..Differences in the phenotypes of Btk-/- and lyn-/- mice suggest that these kinases may also have independent or opposing functions...

Research Grants5

  1. Thrombopoietin Signaling: The Role of Src Kinases
    BRIAN LANNUTTI; Fiscal Year: 2007
    ..2) Examine the role of Src kinases in Tpo-induced signaling by identifying molecules that interact with Lyn; and 3) Study how Src kinases regulate second messenger and downstream components important for cellular ..
  2. Effect of aging on lymphoid stem cells
    David Allman; Fiscal Year: 2002
    ..In Aim 3, we will establish BM chimeras to determine whether age-associated decreases in frequencies of CLPs reflect cell autonomous versus environmental defects. ..
  3. ONTOGENY OF PLASMACYTOID DENDRITIC CELLS
    David Allman; Fiscal Year: 2003
    ..abstract_text> ..
  4. Development of plasmacytoid dendritic cells
    David Allman; Fiscal Year: 2008
    ..Determine the actual contribution of Rag-2+ lymphoid progenitors to each peripheral DC subset including PDCs; and 3. Identify cytokines that can redirect early B cell progenitors into the DC lineage in vitro and in vivo. ..
  5. Aging of Early B Cell Precursors
    David M Allman; Fiscal Year: 2010
    ..Together, these studies will enhance our knowledge of stem cell biology and the basis for age-related defects in early lymphocyte development. ..