Genomes and Genes
Gene Symbol: Lxn
Alias: latexin, ECI, TCI, endogenous carboxypeptidase inhibitor, tissue carboxypeptidase inhibitor
- Cloning, tissue expression pattern and genomic organization of latexin, a human homologue of rat carboxypeptidase A inhibitorQ Liu
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, PR China
Mol Biol Rep 27:241-6. 2000b>Latexin, a carboxypeptidase A inhibitor, is expressed in a cell type-specific manner in both central and peripheral nervous systems in the rat. It is used as a molecular marker for the regional specification of the neocortex...
- An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: relationship to cystatins and the tumor suppressor TIG1Anna Aagaard
Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia
Structure 13:309-17. 2005b>Latexin, the only known mammalian carboxypeptidase inhibitor, has no detectable sequence similarity with plant and parasite inhibitors, but it is related to a human putative tumor suppressor protein, TIG1...
- Reduced pain sensitivity in mice lacking latexin, an inhibitor of metallocarboxypeptidasesMinghao Jin
Mitsubishi Kagaku Institute of Life Sciences, Machida, Tokyo 194 8511, Japan
Brain Res 1075:117-21. 2006b>Latexin, the endogenous protein inhibitor of the A/B subfamily of metallocarboxypeptidases, is expressed in small nociceptive neurons in sensory ganglia and in a subset of neurons in the telencephalon...
- The quantitative trait gene latexin influences the size of the hematopoietic stem cell population in miceYing Liang
Department of Internal Medicine, University of Kentucky, Lexington, Kentucky 40536, USA
Nat Genet 39:178-88. 2007..Using oligonucleotide arrays, real-time PCR and protein blots, we identified latexin (Lxn), a gene whose differential transcription and expression was associated with the allelic differences...
- Latexin regulates the abundance of multiple cellular proteins in hematopoietic stem cellsKanae Mitsunaga
Division of Stem Cell Regulation, Center for Molecular Medicine, Jichi Medical University School of Medicine, Tochigi, Japan
J Cell Physiol 227:1138-47. 2012b>Latexin is the only known carboxypeptidase A inhibitor in mammals and shares structural similarity with cystatin C, suggesting that latexin regulates the abundance of as yet unidentified target proteins...
- Latexin is down-regulated in hematopoietic malignancies and restoration of expression inhibits lymphoma growthYi Liu
Department of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA
PLoS ONE 7:e44979. 2012b>Latexin is a negative regulator of hematopoietic stem cell number in mice. Its dysregulated expression in other tumors led us to hypothesize that latexin may have tumor suppressor properties in hematological malignancies...
- Latexin sensitizes leukemogenic cells to gamma-irradiation-induced cell-cycle arrest and cell death through Rps3 pathwayY You
Department of Internal Medicine, University of Kentucky, Lexington, KY 40536, USA
Cell Death Dis 5:e1493. 2014Leukemia is a leading cause of cancer death. Recently, the latexin (Lxn) gene was identified as a potential tumor suppressor in several types of solid tumors and lymphoma, and Lxn expression was found to be absent or downregulated in ..
- Mapping to mouse chromosome 3 of the gene encoding latexin (Lxn) expressed in neocortical neurons in a region-specific mannerM Jin
Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
Genomics 39:419-21. 1997
- PHOG, a candidate gene for involvement in the short stature of Turner syndromeJ W Ellison
Department of Pediatrics, University of California, San Francisco 94143, USA
Hum Mol Genet 6:1341-7. 1997..We have also found that the mouse homolog of PHOG is autosomal, which may help to explain the lack of a growth abnormality in mice with monosomy X...
- The Atp1b3 gene for Na,K-ATPase beta 3 subunit maps to mouse chromosome 9, and a related gene, Atp1b3-rs, maps to mouse chromosome 3C G Besirli
Kresge Hearing Research Institute, Department of Otolaryngology Head Neck Surgery, University of Michigan Medical School, Ann Arbor 48109 0648, USA
Mamm Genome 9:171-2. 1998
- Two murine and human homologs of mab-21, a cell fate determination gene involved in Caenorhabditis elegans neural developmentM Mariani
Department of Neuroscience, San Raffaele Scientific Institute, Milan, Italy
Hum Mol Genet 8:2397-406. 1999....
- Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouseW H Biggs
Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, California 92093 0660, USA
Mamm Genome 12:416-25. 2001..Further characterization will provide insight into the roles of members of the FKHR subfamily of forkhead-related genes during both normal and neoplastic development...
- DNA microarray profiling of developing PS1-deficient mouse brain reveals complex and coregulated expression changesZ K Mirnics
Department of Pediatrics and Neurology, University of Pittsburgh, School of Medicine, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
Mol Psychiatry 8:863-78. 2003....
- POU-domain factor Brn3a regulates both distinct and common programs of gene expression in the spinal and trigeminal sensory gangliaS Raisa Eng
Department of Psychiatry, University of California, San Diego and VA San Diego Healthcare System, Gilman Drive, La Jolla, CA 92093 0603, USA
Neural Dev 2:3. 2007..Although these ganglia have similar functions, they have distinct embryological origins, in that both contain neurons originating from the neural crest, while only the TG includes cells derived from the placodal ectoderm...
- Latexin is involved in bone morphogenetic protein-2-induced chondrocyte differentiationIchiro Kadouchi
Department of Orthopedic Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan
Biochem Biophys Res Commun 378:600-4. 2009b>Latexin is the only known carboxypeptidase A inhibitor in mammals...
- Nerve injury evoked loss of latexin expression in spinal cord neurons contributes to the development of neuropathic painHilmar Nils Kühlein
Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Goethe Universität Frankfurt am Main, Frankfurt am Main, Germany
PLoS ONE 6:e19270. 2011..the proteins which were regulated in the DIGE analyses after SNI we focused on the carboxypeptidase A inhibitor latexin because protease dysfunctions contribute to the development of neuropathic pain...