Lxn

Summary

Gene Symbol: Lxn
Description: latexin
Alias: latexin, ECI, TCI, endogenous carboxypeptidase inhibitor, tissue carboxypeptidase inhibitor
Species: mouse

Top Publications

  1. ncbi Cloning, tissue expression pattern and genomic organization of latexin, a human homologue of rat carboxypeptidase A inhibitor
    Q Liu
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, PR China
    Mol Biol Rep 27:241-6. 2000
  2. ncbi An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: relationship to cystatins and the tumor suppressor TIG1
    Anna Aagaard
    Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia
    Structure 13:309-17. 2005
  3. ncbi Reduced pain sensitivity in mice lacking latexin, an inhibitor of metallocarboxypeptidases
    Minghao Jin
    Mitsubishi Kagaku Institute of Life Sciences, Machida, Tokyo 194 8511, Japan
    Brain Res 1075:117-21. 2006
  4. ncbi The quantitative trait gene latexin influences the size of the hematopoietic stem cell population in mice
    Ying Liang
    Department of Internal Medicine, University of Kentucky, Lexington, Kentucky 40536, USA
    Nat Genet 39:178-88. 2007
  5. doi Latexin regulates the abundance of multiple cellular proteins in hematopoietic stem cells
    Kanae Mitsunaga
    Division of Stem Cell Regulation, Center for Molecular Medicine, Jichi Medical University School of Medicine, Tochigi, Japan
    J Cell Physiol 227:1138-47. 2012
  6. pmc Latexin is down-regulated in hematopoietic malignancies and restoration of expression inhibits lymphoma growth
    Yi Liu
    Department of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA
    PLoS ONE 7:e44979. 2012
  7. pmc Latexin sensitizes leukemogenic cells to gamma-irradiation-induced cell-cycle arrest and cell death through Rps3 pathway
    Y You
    Department of Internal Medicine, University of Kentucky, Lexington, KY 40536, USA
    Cell Death Dis 5:e1493. 2014
  8. ncbi Mapping to mouse chromosome 3 of the gene encoding latexin (Lxn) expressed in neocortical neurons in a region-specific manner
    M Jin
    Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    Genomics 39:419-21. 1997
  9. ncbi PHOG, a candidate gene for involvement in the short stature of Turner syndrome
    J W Ellison
    Department of Pediatrics, University of California, San Francisco 94143, USA
    Hum Mol Genet 6:1341-7. 1997
  10. ncbi The Atp1b3 gene for Na,K-ATPase beta 3 subunit maps to mouse chromosome 9, and a related gene, Atp1b3-rs, maps to mouse chromosome 3
    C G Besirli
    Kresge Hearing Research Institute, Department of Otolaryngology Head Neck Surgery, University of Michigan Medical School, Ann Arbor 48109 0648, USA
    Mamm Genome 9:171-2. 1998

Scientific Experts

  • S Raisa Eng
  • J W Ellison
  • Ying Liang
  • Y You
  • Kanae Mitsunaga
  • Yi Liu
  • Hilmar Nils Kühlein
  • Ichiro Kadouchi
  • S Raisa Eng
  • Minghao Jin
  • Anna Aagaard
  • Z K Mirnics
  • R Pathak
  • W Li
  • D St Clair
  • D Zhou
  • R Wen
  • A Li
  • Y Liang
  • M Hauer-Jensen
  • Kyle Rector
  • Taeko Wada
  • Subbarao Bondada
  • Carol Swiderski
  • Jason Brandon
  • DIANNA HOWARD
  • J Scott Bryson
  • Lawrence Schook
  • Yusuke Furukawa
  • W H Biggs
  • Jiro Kikuchi
  • Jayesh Mehta
  • Hee Young Lim
  • Katharina Spieth
  • Irmgard Tegeder
  • Christine Moser
  • Corina Ehnert
  • Rolf Marschalek
  • Markus Fauth
  • Ingo Jennes
  • Ellen Niederberger
  • Annett Häussler
  • Michael Karas
  • Gerd Geisslinger
  • Tobias Beckhaus
  • Q Liu
  • Liu Tangjiao
  • Eiji Kobayashi
  • Takashi Murakami
  • Kei Sakamoto
  • Akira Yamaguchi
  • Yuichi Hoshino
  • M Mariani
  • Bruce Aronow
  • Natalia Fedtsova
  • Michael Jansen
  • Iain M Dykes
  • Jason Lanier
  • Eric E Turner
  • Hartmut Geiger
  • Gary Van Zant
  • C G Besirli
  • Reiko Tsuchiya
  • Yuko Katoh-Fukui
  • Shiro Ikegami
  • Toru Higashinakagawa
  • Yasuyoshi Arimatsu
  • Mami Ishida
  • David A Hume
  • Thomas Huber
  • Stuart Kellie
  • Jack U Flanagan
  • Bostjan Kobe
  • Christine A Wells
  • Nathan Cowieson
  • Timothy Ravasi
  • Jennifer L Martin
  • Pawel Listwan
  • M Jin
  • S S Sisodia
  • K Mirnics
  • D Terrano
  • N F Schor
  • D A Lewis
  • K C Arden
  • W K Cavenee
  • S Zhao
  • P Zhang
  • Q Fu
  • J Zhang

Detail Information

Publications16

  1. ncbi Cloning, tissue expression pattern and genomic organization of latexin, a human homologue of rat carboxypeptidase A inhibitor
    Q Liu
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, PR China
    Mol Biol Rep 27:241-6. 2000
    b>Latexin, a carboxypeptidase A inhibitor, is expressed in a cell type-specific manner in both central and peripheral nervous systems in the rat. It is used as a molecular marker for the regional specification of the neocortex...
  2. ncbi An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: relationship to cystatins and the tumor suppressor TIG1
    Anna Aagaard
    Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia
    Structure 13:309-17. 2005
    b>Latexin, the only known mammalian carboxypeptidase inhibitor, has no detectable sequence similarity with plant and parasite inhibitors, but it is related to a human putative tumor suppressor protein, TIG1...
  3. ncbi Reduced pain sensitivity in mice lacking latexin, an inhibitor of metallocarboxypeptidases
    Minghao Jin
    Mitsubishi Kagaku Institute of Life Sciences, Machida, Tokyo 194 8511, Japan
    Brain Res 1075:117-21. 2006
    b>Latexin, the endogenous protein inhibitor of the A/B subfamily of metallocarboxypeptidases, is expressed in small nociceptive neurons in sensory ganglia and in a subset of neurons in the telencephalon...
  4. ncbi The quantitative trait gene latexin influences the size of the hematopoietic stem cell population in mice
    Ying Liang
    Department of Internal Medicine, University of Kentucky, Lexington, Kentucky 40536, USA
    Nat Genet 39:178-88. 2007
    ..Using oligonucleotide arrays, real-time PCR and protein blots, we identified latexin (Lxn), a gene whose differential transcription and expression was associated with the allelic differences...
  5. doi Latexin regulates the abundance of multiple cellular proteins in hematopoietic stem cells
    Kanae Mitsunaga
    Division of Stem Cell Regulation, Center for Molecular Medicine, Jichi Medical University School of Medicine, Tochigi, Japan
    J Cell Physiol 227:1138-47. 2012
    b>Latexin is the only known carboxypeptidase A inhibitor in mammals and shares structural similarity with cystatin C, suggesting that latexin regulates the abundance of as yet unidentified target proteins...
  6. pmc Latexin is down-regulated in hematopoietic malignancies and restoration of expression inhibits lymphoma growth
    Yi Liu
    Department of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA
    PLoS ONE 7:e44979. 2012
    b>Latexin is a negative regulator of hematopoietic stem cell number in mice. Its dysregulated expression in other tumors led us to hypothesize that latexin may have tumor suppressor properties in hematological malignancies...
  7. pmc Latexin sensitizes leukemogenic cells to gamma-irradiation-induced cell-cycle arrest and cell death through Rps3 pathway
    Y You
    Department of Internal Medicine, University of Kentucky, Lexington, KY 40536, USA
    Cell Death Dis 5:e1493. 2014
    Leukemia is a leading cause of cancer death. Recently, the latexin (Lxn) gene was identified as a potential tumor suppressor in several types of solid tumors and lymphoma, and Lxn expression was found to be absent or downregulated in ..
  8. ncbi Mapping to mouse chromosome 3 of the gene encoding latexin (Lxn) expressed in neocortical neurons in a region-specific manner
    M Jin
    Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    Genomics 39:419-21. 1997
  9. ncbi PHOG, a candidate gene for involvement in the short stature of Turner syndrome
    J W Ellison
    Department of Pediatrics, University of California, San Francisco 94143, USA
    Hum Mol Genet 6:1341-7. 1997
    ..We have also found that the mouse homolog of PHOG is autosomal, which may help to explain the lack of a growth abnormality in mice with monosomy X...
  10. ncbi The Atp1b3 gene for Na,K-ATPase beta 3 subunit maps to mouse chromosome 9, and a related gene, Atp1b3-rs, maps to mouse chromosome 3
    C G Besirli
    Kresge Hearing Research Institute, Department of Otolaryngology Head Neck Surgery, University of Michigan Medical School, Ann Arbor 48109 0648, USA
    Mamm Genome 9:171-2. 1998
  11. ncbi Two murine and human homologs of mab-21, a cell fate determination gene involved in Caenorhabditis elegans neural development
    M Mariani
    Department of Neuroscience, San Raffaele Scientific Institute, Milan, Italy
    Hum Mol Genet 8:2397-406. 1999
    ....
  12. ncbi Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse
    W H Biggs
    Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, California 92093 0660, USA
    Mamm Genome 12:416-25. 2001
    ..Further characterization will provide insight into the roles of members of the FKHR subfamily of forkhead-related genes during both normal and neoplastic development...
  13. ncbi DNA microarray profiling of developing PS1-deficient mouse brain reveals complex and coregulated expression changes
    Z K Mirnics
    Department of Pediatrics and Neurology, University of Pittsburgh, School of Medicine, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Psychiatry 8:863-78. 2003
    ....
  14. pmc POU-domain factor Brn3a regulates both distinct and common programs of gene expression in the spinal and trigeminal sensory ganglia
    S Raisa Eng
    Department of Psychiatry, University of California, San Diego and VA San Diego Healthcare System, Gilman Drive, La Jolla, CA 92093 0603, USA
    Neural Dev 2:3. 2007
    ..Although these ganglia have similar functions, they have distinct embryological origins, in that both contain neurons originating from the neural crest, while only the TG includes cells derived from the placodal ectoderm...
  15. doi Latexin is involved in bone morphogenetic protein-2-induced chondrocyte differentiation
    Ichiro Kadouchi
    Department of Orthopedic Surgery, Jichi Medical University, Shimotsuke, Tochigi, Japan
    Biochem Biophys Res Commun 378:600-4. 2009
    b>Latexin is the only known carboxypeptidase A inhibitor in mammals...
  16. pmc Nerve injury evoked loss of latexin expression in spinal cord neurons contributes to the development of neuropathic pain
    Hilmar Nils Kühlein
    Pharmazentrum frankfurt ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Goethe Universität Frankfurt am Main, Frankfurt am Main, Germany
    PLoS ONE 6:e19270. 2011
    ..the proteins which were regulated in the DIGE analyses after SNI we focused on the carboxypeptidase A inhibitor latexin because protease dysfunctions contribute to the development of neuropathic pain...