Ltb4r1

Summary

Gene Symbol: Ltb4r1
Description: leukotriene B4 receptor 1
Alias: BLT1, BLTR, Ltb4r, mBLTR, leukotriene B4 receptor 1, LTB4 receptor, LTB4-R 1, LTB4-R1
Species: mouse

Top Publications

  1. doi The leukotriene B4 receptor, BLT1, is required for the induction of experimental autoimmune encephalomyelitis
    Yasuyuki Kihara
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 394:673-8. 2010
  2. ncbi Characterization of a mouse second leukotriene B4 receptor, mBLT2: BLT2-dependent ERK activation and cell migration of primary mouse keratinocytes
    Yoshiko Iizuka
    Departments of Biochemistry and Molecular Biology and Dermatology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    J Biol Chem 280:24816-23. 2005
  3. pmc Chitin induces accumulation in tissue of innate immune cells associated with allergy
    Tiffany A Reese
    Howard Hughes Medical Institute, Departments of Medicine and Microbiology Immunology, University of California San Francisco, San Francisco, California 94143 0795, USA
    Nature 447:92-6. 2007
  4. ncbi Leukotriene B4 and lipoxin A4 are regulatory signals for neural stem cell proliferation and differentiation
    Koichiro Wada
    Department of Pharmacology, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    FASEB J 20:1785-92. 2006
  5. ncbi Leukotriene B4 receptors BLT1 and BLT2: expression and function in human and murine mast cells
    Katherine A Lundeen
    Alza Johnson and Johnson Pharmaceutical Research and Development, San Diego, CA 92121, USA
    J Immunol 177:3439-47. 2006
  6. ncbi Targeted disruption of leukotriene B4 receptors BLT1 and BLT2: a critical role for BLT1 in collagen-induced arthritis in mice
    Wen Hai Shao
    James Graham Brown Cancer Center, and Department of Microbiology and Immunology, University of Louisville Health Sciences Center, Louisville, KY 40202, USA
    J Immunol 176:6254-61. 2006
  7. pmc 12(S)-Hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2
    Toshiaki Okuno
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    J Exp Med 205:759-66. 2008
  8. doi Protective role of the leukotriene B4 receptor BLT2 in murine inflammatory colitis
    Yoshiko Iizuka
    Department of Medical Biochemistry, Graduate School of Medical Sciences, The University of Tokyo, Tokyo, Japan
    FASEB J 24:4678-90. 2010
  9. pmc Leukotriene B4 amplifies NF-κB activation in mouse macrophages by reducing SOCS1 inhibition of MyD88 expression
    Carlos H Serezani
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan 48109 5642, USA
    J Clin Invest 121:671-82. 2011
  10. pmc Deficiency of the leukotriene B4 receptor, BLT-1, protects against systemic insulin resistance in diet-induced obesity
    Matthew Spite
    Division of Cardiovascular Medicine, Diabetes and Obesity Center, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Immunol 187:1942-9. 2011

Scientific Experts

  • T Yokomizo
  • Kae Hirata
  • Claire M Lucas
  • Miho Asahara
  • Michiko K Oyoshi
  • Erwin W Gelfand
  • Jens Mollerup
  • Koichiro Wada
  • Bodduluri Haribabu
  • Carlos H Serezani
  • Matthew Spite
  • Andrew D Luster
  • Andrew M Tager
  • Takao Shimizu
  • Nobuaki Miyahara
  • Yoshiko Iizuka
  • Toshiaki Okuno
  • Wen Hai Shao
  • Benjamin D Medoff
  • Kazuko Saeki
  • Richard M Locksley
  • Marc Peters-Golden
  • Kan Terawaki
  • Azzeddine Dakhama
  • Katsuyuki Takeda
  • David M Lee
  • Richard C Chou
  • Akiko Toda
  • Takako Ichiki
  • Nancy D Kim
  • Edward Seung
  • Vince C de Hoog
  • Laurence E Cheng
  • Yu Sawada
  • Samia Akthar
  • B C Roy
  • Jiaoyan Lv
  • Annalisa Del Prete
  • Adriana Secatto
  • Shigeki Matsubara
  • Zhuo Wang
  • Michael L Patnode
  • Toshiyuki Koya
  • Katrin D Mayer-Barber
  • Satoko Miyahara
  • Christian Taube
  • Pietro Roversi
  • Hirotoki Ohkubo
  • Robert E Gerszten
  • Yosuke Yokota
  • Neha Sehgal
  • Krishnaprasad Subbarao
  • Koichi Waseda
  • Ana Paula T Monteiro
  • Hong Erh Liang
  • Claudio Canetti
  • Masataka Majima
  • Claudia F Benjamim
  • Yoshiya Ito
  • Maria Fernanda de Souza Costa
  • Hirokazu Saiwai
  • Steven P Mathis
  • Masashi Fukayama
  • Yasuyuki Kihara
  • Mei Chen
  • Maya Eisenring
  • Satoshi Ishii
  • Amy S McKee
  • Hisako Hikiji
  • Eric Gaudreault
  • Nico Van Rooijen
  • Sohei Ito
  • Tiffany A Reese
  • Venkatakrishna R Jala
  • Neil Ahluwalia
  • Tianjiang Liao
  • Bryce A Binstadt
  • Katherine A Lundeen
  • Terry K Means
  • Eric A Heller
  • Katharina Lotzer
  • Tsugunobu Andoh
  • Anthony Joetham
  • Sabina A Islam
  • Melanie J Scott
  • Tomoaki Koga
  • Yasuhiko Yamamoto
  • Masakiyo Sakaguchi
  • Annemieke Kavelaars
  • Hiroshi Yamamoto

Detail Information

Publications74

  1. doi The leukotriene B4 receptor, BLT1, is required for the induction of experimental autoimmune encephalomyelitis
    Yasuyuki Kihara
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 394:673-8. 2010
    ..These cells are a key component of inflammation and all express BLT1, a high affinity G-protein-coupled receptor for LTB(4)...
  2. ncbi Characterization of a mouse second leukotriene B4 receptor, mBLT2: BLT2-dependent ERK activation and cell migration of primary mouse keratinocytes
    Yoshiko Iizuka
    Departments of Biochemistry and Molecular Biology and Dermatology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    J Biol Chem 280:24816-23. 2005
    ..Two G-protein-coupled receptors for LTB4, BLT1 and BLT2, have been cloned from human and shown to be high and low affinity LTB4 receptors, respectively...
  3. pmc Chitin induces accumulation in tissue of innate immune cells associated with allergy
    Tiffany A Reese
    Howard Hughes Medical Institute, Departments of Medicine and Microbiology Immunology, University of California San Francisco, San Francisco, California 94143 0795, USA
    Nature 447:92-6. 2007
    ..Chitin is a recognition element for tissue infiltration by innate cells implicated in allergic and helminth immunity and this process can be negatively regulated by a vertebrate chitinase...
  4. ncbi Leukotriene B4 and lipoxin A4 are regulatory signals for neural stem cell proliferation and differentiation
    Koichiro Wada
    Department of Pharmacology, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    FASEB J 20:1785-92. 2006
    ..These results indicate for the first time that LTB(4) and LXA(4) directly regulate proliferation and differentiation of NSCs, suggesting these new pathways may be useful in restoring stem cells...
  5. ncbi Leukotriene B4 receptors BLT1 and BLT2: expression and function in human and murine mast cells
    Katherine A Lundeen
    Alza Johnson and Johnson Pharmaceutical Research and Development, San Diego, CA 92121, USA
    J Immunol 177:3439-47. 2006
    ..The actions of LTB4 are mediated by two cell surface receptors, BLT1, which is predominantly expressed in peripheral blood leukocytes, and BLT2, which is expressed more ubiquitously...
  6. ncbi Targeted disruption of leukotriene B4 receptors BLT1 and BLT2: a critical role for BLT1 in collagen-induced arthritis in mice
    Wen Hai Shao
    James Graham Brown Cancer Center, and Department of Microbiology and Immunology, University of Louisville Health Sciences Center, Louisville, KY 40202, USA
    J Immunol 176:6254-61. 2006
    Leukotriene B(4) mediates diverse inflammatory diseases through the G protein-coupled receptors BLT1 and BLT2. In this study, we developed mice deficient in BLT1 and BLT2 by simultaneous targeted disruption of these genes...
  7. pmc 12(S)-Hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2
    Toshiaki Okuno
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    J Exp Med 205:759-66. 2008
    ..We conclude that 12-HHT is a natural lipid agonist of BLT2 in vivo and induces chemotaxis of mast cells...
  8. doi Protective role of the leukotriene B4 receptor BLT2 in murine inflammatory colitis
    Yoshiko Iizuka
    Department of Medical Biochemistry, Graduate School of Medical Sciences, The University of Tokyo, Tokyo, Japan
    FASEB J 24:4678-90. 2010
    ..Despite the well-defined proinflammatory roles of BLT1, the in vivo functions of BLT2 remain elusive...
  9. pmc Leukotriene B4 amplifies NF-κB activation in mouse macrophages by reducing SOCS1 inhibition of MyD88 expression
    Carlos H Serezani
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan 48109 5642, USA
    J Clin Invest 121:671-82. 2011
    ..of the known TLRs, except TLR3, as well as IL-1β and IL-18) are reduced in mice lacking either 5-LO or the LTB4 receptor BTL1, and that macrophages from these mice are impaired in MyD88-dependent activation of NF-κB...
  10. pmc Deficiency of the leukotriene B4 receptor, BLT-1, protects against systemic insulin resistance in diet-induced obesity
    Matthew Spite
    Division of Cardiovascular Medicine, Diabetes and Obesity Center, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Immunol 187:1942-9. 2011
    ....
  11. ncbi Absence of leukotriene B4 receptor 1 confers resistance to airway hyperresponsiveness and Th2-type immune responses
    Kan Terawaki
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Tokyo, Japan
    J Immunol 175:4217-25. 2005
    ..Based on the finding that leukotriene B4 receptor 1 (BLT1) is expressed highly in Th2 lymphocytes, we analyzed the roles of BLT1 using an OVA-induced ..
  12. pmc Requirement for leukotriene B4 receptor 1 in allergen-induced airway hyperresponsiveness
    Nobuaki Miyahara
    National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Am J Respir Crit Care Med 172:161-7. 2005
    ..is a rapidly synthesized, early leukocyte chemoattractant that signals via its cell surface receptor, leukotriene B4 receptor 1 (BLT1), to attract and activate leukocytes during inflammation...
  13. ncbi Leukotriene binding, signaling, and analysis of HIV coreceptor function in mouse and human leukotriene B4 receptor-transfected cells
    V Martin
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 274:8597-603. 1999
    The mouse leukotriene B4 receptor (m-BLTR) gene was cloned. Membrane fractions of human embryonic kidney 293 cells stably expressing m-BLTR demonstrated a high affinity and specific binding for leukotriene B4 (LTB4, Kd = 0.24 +/- 0.03 nM)...
  14. pmc Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion
    N Chiang
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Invest 104:309-16. 1999
    ..components controlling PMNs in vivo, we prepared novel transgenic mice with the human leukotriene (LT) B4 receptor (BLTR) for functional characterization...
  15. pmc Molecular and biological characterization of the murine leukotriene B4 receptor expressed on eosinophils
    W W Huang
    Infectious Disease Unit, AIDS Research Center, Department of Medicine, Massachusetts General Hospital, Charlestown 02129, USA
    J Exp Med 188:1063-74. 1998
    ..Our findings indicate that this murine receptor is an LTB4 receptor that is highly expressed on activated leukocytes, including eosinophils, and may play an important role in ..
  16. ncbi Leukotriene B4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues
    Katayoon Goodarzi
    Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 4:965-73. 2003
    Leukotriene B4 (LTB4) is a potent chemoattractant for myeloid leukocytes, which express BLT1, the high-affinity receptor for LTB4...
  17. pmc Targeted disruption of the leukotriene B(4) receptor in mice reveals its role in inflammation and platelet-activating factor-induced anaphylaxis
    B Haribabu
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Exp Med 192:433-8. 2000
    ..Leukotriene B(4) (LTB(4)) and leukotriene C(4) (LTC(4)) act through G protein-coupled receptors LTB(4) receptor (BLTR) and Cys-LTR, respectively...
  18. pmc BLTR mediates leukotriene B(4)-induced chemotaxis and adhesion and plays a dominant role in eosinophil accumulation in a murine model of peritonitis
    A M Tager
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Exp Med 192:439-46. 2000
    ..A seven transmembrane-spanning, G protein-coupled receptor, called BLTR (LTB(4) receptor), has recently been identified as an LTB(4) receptor...
  19. ncbi Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment
    Andrew M Tager
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Immunol 4:982-90. 2003
    ..rapidly generated from innate immune cells, that activates leukocytes through the G protein-coupled receptor BLT1. We report here that BLT1 is expressed on effector CD4+ T cells generated in vitro as well as in vivo when effector ..
  20. pmc The leukotriene B₄/BLT₁ axis is a key determinant in susceptibility and resistance to histoplasmosis
    Adriana Secatto
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    PLoS ONE 9:e85083. 2014
    ..a higher fungal burden in the lung and spleen, increased mortality, lower expression levels of 5-LO and leukotriene B4 receptor 1 (BLT1) and decreased LTB4 production compared to the resistant 129/Sv mice...
  21. doi BLT1 antagonist LSN2792613 reduces infarct size in a mouse model of myocardial ischaemia-reperfusion injury
    Vince C de Hoog
    Laboratory of Experimental Cardiology, UMC Utrecht, Room G02 523, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Cardiovasc Res 108:367-76. 2015
    ..B4 is an important leucocyte chemoattractant, performing its actions through binding to its specific receptor BLT1. We hypothesized that treatment with LSN2792613, a selective BLT1 antagonist, reduces infarct size (IS) in a mouse ..
  22. pmc Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses
    Yu Sawada
    Department of Dermatology and Center for Innovation in Immunoregulative Technology and Therapeutics, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8501, Japan Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 807 8555, Japan
    J Exp Med 212:1921-30. 2015
    ..B4 (LTB4) induced actin filament reorganization in DCs and increased DC motility by activating Cdc42 and Rac1 via BLT1, which was abrogated by RvE1...
  23. pmc Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection
    Samia Akthar
    Leukocyte Biology Section, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK
    Nat Commun 6:8423. 2015
    ..This highlights a critical role for the secondary anti-inflammatory activity of LTA4H and thus has consequences for the generation of global LTA4H inhibitors currently being developed. ..
  24. doi Leukotriene B4 type-1 receptor signaling promotes liver repair after hepatic ischemia/reperfusion injury through the enhancement of macrophage recruitment
    Hirotoki Ohkubo
    Department of Pharmacology, Kitasato University School of Medicine, 1 15 1 Kitasato, Minami, Sagamihara Kanagawa, 252 0374, Japan
    FASEB J 27:3132-43. 2013
    ..Leukotriene B4 (LTB4) is a potent chemoattractant for macrophages. In this study, we investigated the role of LTB4 receptor type 1 (BLT1) in liver repair during hepatic ischemia/reperfusion (I/R) injury...
  25. pmc Leukotriene B₄-leukotriene B₄ receptor axis promotes oxazolone-induced contact dermatitis by directing skin homing of neutrophils and CD8⁺ T cells
    Jiaoyan Lv
    Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China
    Immunology 146:50-8. 2015
    ..B4 (LTB4 ) is a lipid mediator that is rapidly generated in inflammatory sites, and its functional receptor, BLT1, is mostly expressed on immune cells...
  26. pmc Leukotriene B4 enhances the generation of proinflammatory microRNAs to promote MyD88-dependent macrophage activation
    Zhuo Wang
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202
    J Immunol 192:2349-56. 2014
    ..Our data show that LTB4, via its receptor B leukotriene receptor 1 (BLT1) and Gαi signaling, increased macrophage expression of inflammatory microRNAs, including miR-155, miR-146b, and ..
  27. pmc Leukotriene B4 amplifies eosinophil accumulation in response to nematodes
    Michael L Patnode
    Department of Anatomy, Program in Biomedical Sciences, Howard Hughes Medical Institute, Department of Medicine, and Department of Pathology, University of California, San Francisco, San Francisco, CA 94143Department of Anatomy, Program in Biomedical Sciences, Howard Hughes Medical Institute, Department of Medicine, and Department of Pathology, University of California, San Francisco, San Francisco, CA 94143
    J Exp Med 211:1281-8. 2014
    ..The similarity of the eosinophil responses to diverse nematode species suggests that conserved features of nematodes are recognized during parasite infection...
  28. pmc Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk
    Katrin D Mayer-Barber
    Immunobiology Section, Laboratory of Parasitic Diseases LPD, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Bethesda, Maryland 20892, USA
    Nature 511:99-103. 2014
    ..Our findings establish proof of concept for host-directed treatment strategies that manipulate the host eicosanoid network and represent feasible alternatives to conventional chemotherapy. ..
  29. pmc Low leukotriene B4 receptor 1 leads to ALOX5 downregulation at diagnosis of chronic myeloid leukemia
    Claire M Lucas
    Department of Molecular and Clinical Cancer Medicine Haematology, University of Liverpool, UK
    Haematologica 99:1710-5. 2014
    ..However, the LTB4 receptor (BLT1) protein in newly diagnosed patients was significantly lower than after a period of treatment (P<0...
  30. doi Modulation of leukotriene B4 receptor 1 signaling by receptor for advanced glycation end products (RAGE)
    Takako Ichiki
    Department of Biochemistry, Juntendo University School of Medicine, Tokyo, Japan
    FASEB J 30:1811-22. 2016
    ..Ichiki, T., Koga, T., Okuno, T., Saeki K., Yamamoto, Y., Yamamoto, H., Sakaguchi, M., Yokomizo, T. Modulation of leukotriene B4 receptor 1 signaling by receptor for advanced glycation end products (RAGE).
  31. doi Two distinct leukotriene B4 receptors, BLT1 and BLT2
    Takehiko Yokomizo
    Department of Biochemistry, Graduate School of Medicine, Juntendo University, Hongo 2 1 1, Bunkyo ku, Tokyo 113 8421, Japan
    J Biochem 157:65-71. 2015
    ..Two G protein-coupled receptors for LTB4 have been identified: a high-affinity receptor, BLT1, and a low-affinity receptor, BLT2...
  32. pmc Role of bacterial infection in the epigenetic regulation of Wnt antagonist WIF1 by PRC2 protein EZH2
    B C Roy
    Departments of Molecular and Integrative Physiology and Family Medicine Research Division, University of Kansas Medical Center, Kansas City, KS, USA
    Oncogene 34:4519-30. 2015
    ..NIH:Swiss outbred and Apc(Min/+) mice were infected with CR (10(8) CFU); BLT1(-/-)Apc(Min/+) mice, azoxymethane (AOM)/dextran sodium sulfate (DSS)-treated mice and de-identified human ..
  33. pmc IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function
    Laurence E Cheng
    Department of Pediatrics, Department of Medicine, Department of Anatomy, Sandler Asthma Basic Research Center, Cardiovascular Research Institute, Department of Microbiology and Immunology, and Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143 Department of Pediatrics, Department of Medicine, Department of Anatomy, Sandler Asthma Basic Research Center, Cardiovascular Research Institute, Department of Microbiology and Immunology, and Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143
    J Exp Med 212:513-24. 2015
    ..Thus, basophils are gatekeepers that link adaptive immunity with innate effector programs by altering access to tissue sites by activation-induced interactions with the endothelium. ..
  34. pmc Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axis
    C Henrique Serezani
    Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA
    J Immunol 189:906-15. 2012
    ..LTB(4) production and signaling through its high-affinity G protein-coupled receptor leukotriene B(4) receptor 1 (BLT1) direct dectin-1-dependent binding, ingestion, and cytokine production both in vitro and in vivo...
  35. doi Absence of LTB4/BLT1 axis facilitates generation of mouse GM-CSF-induced long-lasting antitumor immunologic memory by enhancing innate and adaptive immune systems
    Yosuke Yokota
    Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Blood 120:3444-54. 2012
    b>BLT1 is a high-affinity receptor for leukotriene B4 (LTB4) that is a potent lipid chemoattractant for myeloid leukocytes. The role of LTB4/BLT1 axis in tumor immunology, including cytokine-based tumor vaccine, however, remains unknown...
  36. pmc Leukotriene B4-driven neutrophil recruitment to the skin is essential for allergic skin inflammation
    Michiko K Oyoshi
    Division of Immunology, Boston Children s Hospital, MA 02115, USA
    Immunity 37:747-58. 2012
    ..was largely dependent on the generation of leukotriene B4 (LTB4) by neutrophils and their expression of the LTB4 receptor BLT1...
  37. pmc Bifunctional lipocalin ameliorates murine immune complex-induced acute lung injury
    Pietro Roversi
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    J Biol Chem 288:18789-802. 2013
    ..The findings suggest that dual inhibition of C5 and LTB4 may be useful for treatment of human immune complex-dependent diseases. ..
  38. ncbi Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment
    Eric A Heller
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, East 8307, 149 13th St, Charlestown, MA 02129, USA
    Circulation 112:578-86. 2005
    ..LTB(4) signals primarily through its high-affinity G protein-coupled receptor BLT1, which is expressed on specific leukocyte subsets...
  39. pmc Regulation of dendritic cell migration and adaptive immune response by leukotriene B4 receptors: a role for LTB4 in up-regulation of CCR7 expression and function
    Annalisa Del Prete
    Tumor Immunobiology Program, James Graham Brown Cancer Center, Departmnet of Microbiology and Immunology, University of Louisville Health Sciences Center, KY 40202, USA
    Blood 109:626-31. 2007
    ..BM-DCs cultured from BLT1-/- or BLT1/2-/- mice showed a normal phenotype, but in vivo BLT1/2-/-DCs showed dramatic decrease in migration to ..
  40. doi Leukotriene B4 mediates neutrophil migration induced by heme
    Ana Paula T Monteiro
    Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    J Immunol 186:6562-7. 2011
    ..of mice was attenuated by pretreatment with 5-lipoxygenase (5-LO) inhibitors and leukotriene B(4) receptor 1 (BLT1) receptor antagonists as well as in 5-LO knockout (5-LO(-/-)) mice...
  41. ncbi The leukotriene B4 receptor (BLT1) is required for effector CD8+ T cell-mediated, mast cell-dependent airway hyperresponsiveness
    Christian Taube
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 176:3157-64. 2006
    ..responsiveness following transfer of CD8+ T(EFF) or in wild-type mice could be blocked by administration of an LTB4 receptor antagonist confirming the role of BLT1 in CD8+ T cell-mediated AHR...
  42. ncbi Particularities of the vasculature can promote the organ specificity of autoimmune attack
    Bryce A Binstadt
    Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 7:284-92. 2006
    ..We propose that regionally distinct vascular properties 'interface' with immune effector pathways to foster organ-specific autoimmune damage, perhaps explaining why arthritis accompanies many human infectious and autoimmune disorders...
  43. ncbi Antibody-antigen interaction in the airway drives early granulocyte recruitment through BLT1
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Am J Physiol Lung Cell Mol Physiol 290:L170-8. 2006
    ..released following antigen challenge that has chemotactic activity for granulocytes, mediated through its receptor, BLT1. We investigated the role of BLT1 in granulocyte recruitment following antigen challenge...
  44. ncbi The 5-lipoxygenase pathway in arterial wall biology and atherosclerosis
    Katharina Lotzer
    Institute for Vascular Medicine, Friedrich Schiller University of Jena, Bachstr 18, 07743 Jena, Germany
    Biochim Biophys Acta 1736:30-7. 2005
    ..We will attempt to propose strategies to further explore potential links between the 5-LO pathway and blood vessel physiology and disease progression...
  45. doi Cytochrome P4504f, a potential therapeutic target limiting neuroinflammation
    Neha Sehgal
    Division of Molecular and Cellular Neuroscience, National Brain Research Centre, Nainwal Mode, Haryana, India
    Biochem Pharmacol 82:53-64. 2011
    ..Thus, catalytic activity of Cyp4fs is a novel target for modulating neuroinflammation through hydroxylation of LTB(4)...
  46. pmc BLT1-mediated T cell trafficking is critical for rejection and obliterative bronchiolitis after lung transplantation
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Exp Med 202:97-110. 2005
    ..has been shown to have potent chemotactic activity for effector T lymphocytes mediated through its receptor, BLT1. Here, we developed a novel murine model of acute lung rejection to demonstrate that BLT1 controls effector CD8+ T ..
  47. ncbi Expression of BLT1 leukotriene B4 receptor on the dorsal root ganglion neurons in mice
    Tsugunobu Andoh
    Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Brain Res Mol Brain Res 137:263-6. 2005
    We investigated using mice whether dorsal root ganglion (DRG) neurons express leukotriene B4 receptors. BLT1, but not BLT2, receptor mRNA was expressed in the DRG...
  48. ncbi Leukotriene B4 receptor-1 is essential for allergen-mediated recruitment of CD8+ T cells and airway hyperresponsiveness
    Nobuaki Miyahara
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 174:4979-84. 2005
    ..Recently, leukotriene B4 and its high affinity receptor, BLT1, have been shown to mediate in vitro-generated T(EFF) recruitment into inflamed tissues...
  49. pmc Leukotriene B4 receptor (BLT-1) modulates neutrophil influx into the peritoneum but not the lung and liver during surgically induced bacterial peritonitis in mice
    Melanie J Scott
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Clin Diagn Lab Immunol 11:936-41. 2004
    ..Despite higher bacterial and PMN levels at remote sites, there was increased survival in BLT-1(-/-) mice compared to WT mice. Decreased PMN activation may result in less remote organ dysfunction and improved survival...
  50. ncbi Role of leukotriene B4 receptors in the development of atherosclerosis: potential mechanisms
    Krishnaprasad Subbarao
    James Graham Brown Cancer Center, University of Louisville Health Sciences, Louisville, KY 40202, USA
    Arterioscler Thromb Vasc Biol 24:369-75. 2004
    ..We sought to determine mechanisms through which LTB4 modulates atherosclerosis in cell lines expressing LTB4 receptors, BLT-1, and in mice deficient in BLT-1 as well as macrophage cell lines derived from BLT-1+/+ and BLT-1-/- mice...
  51. ncbi Increased acute inflammation, leukotriene B4-induced chemotaxis, and signaling in mice deficient for G protein-coupled receptor kinase 6
    Annemieke Kavelaars
    Laboratory for Psychoneuroimmunology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Immunol 171:6128-34. 2003
    ..LTB(4) exerts its action via binding to BLT1, a G protein-coupled receptor...
  52. ncbi BLT1 and BLT2: the leukotriene B(4) receptors
    Andrew M Tager
    Division of Rheumatology, Allergy and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Building 149 8301, 13th Street, Charlestown, MA 02129, USA
    Prostaglandins Leukot Essent Fatty Acids 69:123-34. 2003
    Two receptors for leukotriene B(4) (LTB(4)) have been molecularly identified: BLT1 and BLT2...
  53. ncbi Leukotriene B4: metabolism and signal transduction
    T Yokomizo
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, CREST of Japan, Science and Technology Corporation
    Arch Biochem Biophys 385:231-41. 2001
    ..Two G-protein-coupled receptors (BLT1 and BLT2) have been cloned and characterized...
  54. ncbi Characterization of the cloned guinea pig leukotriene B4 receptor: comparison to its human orthologue
    Y Boie
    Department of Biochemistry and Molecular Biology, Merck Frosst Center for Therapeutic Research, Pointe Claire Dorval, Quebec, Canada
    Eur J Pharmacol 380:203-13. 1999
    ..The recombinant guinea pig BLT receptor will permit the comparison of the intrinsic potencies of leukotriene B4 receptor antagonists used in guinea pig in vivo models of allergic and inflammatory disorders...
  55. pmc A distinctive role of the leukotriene B4 receptor BLT1 in osteoclastic activity during bone loss
    Hisako Hikiji
    Department of Oral and Maxillofacial Surgery, Faculty of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    Proc Natl Acad Sci U S A 106:21294-9. 2009
    ..Using mice deficient in the high-affinity LTB(4) receptor BLT1, we evaluated the roles of BLT1 in the development of two bone resorption models, namely bone loss induced by ..
  56. ncbi Inhibited aortic aneurysm formation in BLT1-deficient mice
    Neil Ahluwalia
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Immunol 179:691-7. 2007
    ..Leukotriene B(4) signals primarily through its high-affinity G protein-coupled receptor, BLT1, which is highly expressed on specific leukocyte subsets...
  57. ncbi Homologous desensitisation of the mouse leukotriene B4 receptor involves protein kinase C-mediated phosphorylation of serine 127
    Jens Mollerup
    Department of Molecular Biology, University of Copenhagen, Copenhagen, Denmark
    Cell Physiol Biochem 20:143-56. 2007
    ..U75302, specifically targeting BLT1, significantly reduced LTB(4)-evoked Cl(-) currents...
  58. ncbi Leukotriene B4/leukotriene B4 receptor pathway is involved in hepatic microcirculatory dysfunction elicited by endotoxin
    Sohei Ito
    Department of Pharmacology, Kitasato University of Medicine, Kanagawa, Japan
    Shock 30:87-91. 2008
    ..However, the contribution of LTB4 to liver microcirculatory dysfunction during endotoxemia remains unknown. LTB4 receptor (BLT1) has been identified as a high-affinity receptor specific for LTB4...
  59. pmc A unique requirement for the leukotriene B4 receptor BLT1 for neutrophil recruitment in inflammatory arthritis
    Nancy D Kim
    Division of Rheumatology, Allergy, and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Exp Med 203:829-35. 2006
    ..However, here we demonstrate a unique, non-redundant role for the leukotriene B4 receptor BLT1 in mediating neutrophil recruitment into the joint in the K/BxN mouse model of inflammatory arthritis...
  60. ncbi Leukotriene B4 induces release of antimicrobial peptides in lungs of virally infected mice
    Eric Gaudreault
    Laboratory of Viral Immunology, Rheumatology and Immunology Research Center, Centre Hospitalier de l Universite Laval Research Center, 2705 Boulevard Laurier, Quebec, Canada
    J Immunol 180:6211-21. 2008
    ..Together, these results demonstrate the importance of neutrophils and the secretion of antimicrobial peptides during the early immune response mediated by LTB(4) against a viral pathogen...
  61. ncbi Leukotriene B4 receptor 1 expression on dendritic cells is required for the development of Th2 responses and allergen-induced airway hyperresponsiveness
    Nobuaki Miyahara
    Department of Pediatrics, Division of Cell Biology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 181:1170-8. 2008
    ..Leukotriene B(4) (LTB(4)), interacting with its high-affinity receptor, LTB(4) receptor 1 (BLT1), is known to attract and activate leukocytes during inflammation...
  62. pmc FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions
    Carlos H Serezani
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109 5642, USA
    Blood 114:3316-24. 2009
    ..In this study, we report that the LTB(4) receptor leukotriene B(4) receptor 1 (BLT1) redistributes from nonlipid raft (LR) to LR membrane microdomains upon immunoglobulin G-red blood cell, but not ..
  63. pmc Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity
    Amy S McKee
    Howard Hughes Medical Institute, Denver, CO 80206, USA
    J Immunol 183:4403-14. 2009
    ..These data suggest that activation of the inflammasome and the type 2 innate response orchestrated by macrophages and mast cells in vivo are not required for adjuvant effect of alum on endogenous T and B cell responses...
  64. pmc Leukotriene B4 mediates gammadelta T lymphocyte migration in response to diverse stimuli
    Maria Fernanda de Souza Costa
    Laboratório de Farmacologia Aplicada, Farmanguinhos, Fundacao Oswaldo Cruz, Manguinhos, Rio de Janeiro, RJ, CEP 21041 250, Brazil
    J Leukoc Biol 87:323-32. 2010
    ..pl. LPS. Antagonists of the high-affinity LTB(4) receptor BLT1, CP105,696, and LY292476 also attenuated LPS-induced gammadelta T cell accumulation in pleural cavities as well as ..
  65. pmc Blocking the leukotriene B4 receptor 1 inhibits late-phase airway responses in established disease
    Koichi Waseda
    Department of Hematology, Oncology, Allergy and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    Am J Respir Cell Mol Biol 45:851-7. 2011
    Most of the studies investigating the effectiveness of blocking the leukotriene B4 (LTB4) receptor 1 (BLT1) have been performed in models of primary or acute allergen challenge...
  66. doi Attenuated Th1 induction by dendritic cells from mice deficient in the leukotriene B4 receptor 1
    Akiko Toda
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Tokyo 113 0033, Japan
    Biochimie 92:682-91. 2010
    ..However, little information is available on the roles of LTB4 and its receptor BLT1 in DCs...
  67. pmc The LTB4-BLT1 axis mediates neutrophil infiltration and secondary injury in experimental spinal cord injury
    Hirokazu Saiwai
    Department of Research Superstar Program Stem Cell Unit, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Am J Pathol 176:2352-66. 2010
    ..and monocyte/macrophage infiltration peaked 12 hours after injury and was significantly suppressed in leukotriene B4 receptor 1 knockout mice. Similar findings were observed in mice treated with a leukotriene B4 receptor antagonist...
  68. doi Nonredundant roles for leukotriene B4 receptors BLT1 and BLT2 in inflammatory arthritis
    Steven P Mathis
    James Graham Brown Cancer Center, Louisville, KY 40202, USA
    J Immunol 185:3049-56. 2010
    ..Studies in mouse models demonstrated an important role for the high-affinity leukotriene B(4) receptor BLT1 in arthritis, atherosclerosis, and asthma...
  69. ncbi Blockade of the interaction of leukotriene b4 with its receptor prevents development of autoimmune uveitis
    Tianjiang Liao
    Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, Louisville, Kentucky, USA
    Invest Ophthalmol Vis Sci 47:1543-9. 2006
    To investigate the role of leukotriene B4 (LTB4) and its receptor BLT1 in the pathogenesis of mouse uveitis.
  70. pmc Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis
    Richard C Chou
    Division of Rheumatology, Allergy, and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Immunity 33:266-78. 2010
    ..demonstrated an absolute requirement for the lipid chemoattractant leukotriene B(4) (LTB(4)) and its receptor BLT1 for neutrophil recruitment into the joint in autoantibody-induced arthritis...
  71. pmc Joint tissues amplify inflammation and alter their invasive behavior via leukotriene B4 in experimental inflammatory arthritis
    Mei Chen
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 185:5503-11. 2010
    ..Our results identify novel roles for FLSs and LTB(4) in joints, placing LTB(4) regulation of FLS biology at the center of a previously unrecognized amplification loop for synovial inflammation and tissue pathology...
  72. doi IL-12 initiates tumor rejection via lymphoid tissue-inducer cells bearing the natural cytotoxicity receptor NKp46
    Maya Eisenring
    Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
    Nat Immunol 11:1030-8. 2010
    ..Thus, this innate cell type is responsive to IL-12 and is a powerful mediator of tumor suppression...
  73. ncbi CD8+ T lymphocytes and leukotriene B4: novel interactions in the persistence and progression of asthma
    Erwin W Gelfand
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 117:577-82. 2006
    ..CD8+ T cells, effector memory CD8+ T cells in the mouse, express a high-affinity receptor for leukotriene B4 (BLT1), and expression of this receptor is essential for their accumulation in the lung and development of airway ..
  74. pmc Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis
    J C Detter
    Departments of Medicine, Molecular Genetics and Microbiology, Pathology and Laboratory Medicine, and Pediatrics, and Center for Mammalian Genetics, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 97:4144-9. 2000
    ..These findings indicate that geranylgeranylation of Rab GTPases is critical for hemostasis. Rab GGTase inhibition may represent a new treatment for thrombocytosis and clotting disorders...

Research Grants3

  1. MEKK2 Regulation of Mast Cell/T Cell Cytokine Production
    Erwin Gelfand; Fiscal Year: 2003
    ..The studies will also define MEKK2 and ERK5 as targets for drug discovery for the control of allergic inflammation. ..
  2. Naturally occurring T regulatory cells control airway hyperresponsiveness
    Erwin Gelfand; Fiscal Year: 2008
    ..abstract_text> ..