Genomes and Genes
Gene Symbol: Lta
Description: lymphotoxin A
Alias: LT-[a], LT-alpha, LT[a], LTalpha, Ltx, TNF-beta, TNFSF1, Tnfb, Tnfsf1b, Tnlg1e, hlb382, lymphotoxin-alpha, TNF beta, tumor necrosis factor ligand 1e, tumor necrosis factor ligand superfamily member 1
Publications133 found, 100 shown here
- Expression of tumor necrosis factor and c-fos genes in peritoneal macrophages of hypothyroid miceW K Liu
Department of Anatomy, Faculty of Medicine, Chinese University of Hong Kong, Shatin, N T
Inflammation 17:217-25. 1993..These results indicate that the reduction in signal transduction and in the production of antitumor molecules may cause the poor defense ability of hypothyroid animals...
- Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2Y Yokota
Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Gottingen, Germany
Nature 397:702-6. 1999..Our results indicate that Id2 has an essential role in the generation of peripheral lymphoid organs and NK cells...
- An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cellsGerard Eberl
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
Nat Immunol 5:64-73. 2004..This early LTi cell-mediated activation of lymph node and Peyer's patch mesenchyma forms the necessary platform for the subsequent development of mature lymphoid tissues...
- Alternate mucosal immune system: organized Peyer's patches are not required for IgA responses in the gastrointestinal tractM Yamamoto
Department of Clinical Pathology, Nihon University School of Dentistry at Matsudo, Chiba, Japan
J Immunol 164:5184-91. 2000..Further, organized Peyer's patches are not a strict requirement for induction of mucosal IgA Ab responses in the gastrointestinal tract...
- Lymphotoxin-alpha-deficient mice make delayed, but effective, T and B cell responses to influenzaFrances E Lund
Trudeau Institute, Saranac Lake, NY 12983, USA
J Immunol 169:5236-43. 2002Lymphotoxin-alpha(-/-) (LTalpha(-/-)) mice are thought to be unable to generate effective T and B cell responses. This is attributed to the lack of lymph nodes and the disrupted splenic architecture of these mice...
- A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteriaA J MacPherson
Institute of Experimental Immunology, Universitatsspital, Schmelzbergstrasse 12, CH8091, Zurich, Switzerland
Science 288:2222-6. 2000....
- Differentiation of follicular dendritic cells and full antibody responses require tumor necrosis factor receptor-1 signalingM Le Hir
Swiss Institute of Technology, Institute of Toxicology, Schwerzenbach, Switzerland
J Exp Med 183:2367-72. 1996Using mice double deficient for tumor necrosis factor (TNF) and lymphotoxin alpha (LT alpha), we demonstrated that TNF and/or LT alpha are necessary for development of a normal splenic microarchitecture and for isotype switch after ..
- Challenging cytokine redundancy: inflammatory cell movement and clinical course of experimental autoimmune encephalomyelitis are normal in lymphotoxin-deficient, but not tumor necrosis factor-deficient, miceD Sean Riminton
Centenary Institute of Cancer Medicine and Cell Biology, Sydney, New South Wales 2050, Australia
J Exp Med 187:1517-28. 1998..The contribution of LT to experimental autoimmune encephalomyelitis (EAE) was examined using TNF/LTalpha-/- mice, TNF-/- mice, and a new LTalpha-/- line described here...
- Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissueH Korner
Centenary Institute of Cancer Medicine and Cell Biology, Sydney, Australia
Eur J Immunol 27:2600-9. 1997..for the pro-inflammatory cytokines tumor necrosis factor (TNF) and lymphotoxin (LT) were characterized in TNF/LT alpha -/- and TNF -/- mice established by direct gene targeting of C57BL/6 ES cells...
- Locally up-regulated lymphotoxin alpha, not systemic tumor necrosis factor alpha, is the principle mediator of murine cerebral malariaChristian R Engwerda
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom
J Exp Med 195:1371-7. 2002..In contrast, the role of the related cyto-kine lymphotoxin alpha (LTalpha) in CM has been overlooked...
- The lymphotoxin beta receptor is critically involved in controlling infections with the intracellular pathogens Mycobacterium tuberculosis and Listeria monocytogenesStefan Ehlers
Division of Molecular Infection Biology, Research Center Borstel, Borstel, Germany
J Immunol 170:5210-8. 2003..When mice deficient in LT alpha or LT beta were challenged intranasally with Mycobacterium tuberculosis, they showed a significant increase in ..
- Role of CXC chemokine ligand 13, CC chemokine ligand (CCL) 19, and CCL21 in the organization and function of nasal-associated lymphoid tissueJavier Rangel-Moreno
Trudeau Institute, Saranac Lake, NY 12983, USA
J Immunol 175:4904-13. 2005..Unlike other lymphoid organs, NALT develops independently of lymphotoxin-alpha (LTalpha)...
- Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cellsDominik Meier
Division of Developmental Immunology, Center for Biomedicine, Department of Clinical and Biological Sciences DKBW, University of Basel, CH 4058 Basel, Switzerland
Immunity 26:643-54. 2007..Therefore, by controlling LTi cell numbers, IL-7 can regulate the formation of both normal and ectopic lymphoid organs...
- Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsivenessT A Banks
Department of Microbiology, University of Tennessee, Knoxville 37996, USA
J Immunol 155:1685-93. 1995..These data illustrate the utility of this mouse model as a system for understanding lymphoid organ development and its effects on immune responsiveness...
- Role of lymphotoxin and the type I TNF receptor in the formation of germinal centersM Matsumoto
Center for Immunology and Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110, USA
Science 271:1289-91. 1996..Germinal center formation was restored in LT-alpha-deficient mice by transplantation of normal bone marrow, indicating that the LT-alpha-expressing cells required to establish this lymphoid structure are derived from bone marrow...
- Multiple immune abnormalities in tumor necrosis factor and lymphotoxin-alpha double-deficient miceH P Eugster
Swiss Federal Institute of Technology, Institute of Toxicology, Schorenstasse 16, 8603 Schwerzenbach, Switzerland
Int Immunol 8:23-36. 1996..factor (TNF) and lymphotoxin (LT)-alpha in the development and function of the immune system, the Tnf and Ltalpha genes were simultaneously inactivated in mice by homologous recombination...
- Affinity maturation without germinal centres in lymphotoxin-alpha-deficient miceM Matsumoto
Center for Immunology and Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
Nature 382:462-6. 1996..Mice deficient in lymphotoxin-alpha (LT alpha-/- mice) have no lymph nodes or Peyer's patches, and fail to form germinal centres in the spleen...
- Defective Peyer's patch organogenesis in mice lacking the 55-kD receptor for tumor necrosis factorB Neumann
Institute for Medical Microbiology and Hygiene, Technical University of Munich, Germany
J Exp Med 184:259-64. 1996b>Lymphotoxin alpha (LT-alpha) may form secreted homotrimers binding to p55 and p75 tumor necrosis factor (TNF) receptors or cell surface-bound heterotrimers with LT-beta that interact with the LT-beta receptor...
- Lack of type 2 T cell-independent B cell responses and defect in isotype switching in TNF-lymphotoxin alpha-deficient miceB Ryffel
Institute of Pathology, University of Basel, Switzerland
J Immunol 158:2126-33. 1997..Our previous studies had shown that TNF-LT alpha double-deficient mice have defective IgM and IgG primary Ab responses to the T cell-dependent (TD) Ag SRBC...
- Lymphotoxin-alpha (LTalpha) supports development of splenic follicular structure that is required for IgG responsesY X Fu
Department of Laboratory Medicine and Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Exp Med 185:2111-20. 1997b>LTalpha-deficient (LTalpha-/-) mice show altered splenic microarchitecture. This includes loss of normal B cell-T cell compartmentalization, of follicular dendritic cell (FDC) clusters, and of ability to form germinal centers (GC)...
- The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissuesA Fütterer
Institute of Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, Germany
Immunity 9:59-70. 1998..Since LTbetaR-/- mice exhibit distinct defects when compared to LTalpha-/- and LTbeta-/- mice, it is suggested that the LTbetaR integrates signals from other TNF family members...
- Tumor necrosis factor and the p55TNF receptor are required for optimal development of the marginal sinus and for migration of follicular dendritic cell precursors into splenic folliclesM Pasparakis
Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, 115 21, Greece
Cell Immunol 201:33-41. 2000....
- Initiation of NALT organogenesis is independent of the IL-7R, LTbetaR, and NIK signaling pathways but requires the Id2 gene and CD3(-)CD4(+)CD45(+) cellsSatoshi Fukuyama
Department of Mucosal Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
Immunity 17:31-40. 2002....
- Distinct contributions of TNF and LT cytokines to the development of dendritic cells in vitro and their recruitment in vivoKoichiro Abe
Laboratory of Molecular Immunoregulation, Center for Cancer Research and Basic Research Program, SAIC Frederick, National Cancer Institute, MD 21702, USA
Blood 101:1477-83. 2003TNF/LTalpha/LTbeta (tumor necrosis factor/lymphotoxin-alpha/lymphotoxin-beta) triple knockout (KO) mice show a significant reduction of dendritic cell (DC) number in the spleen, presumably due to defective recruitment and/or production...
- Lymphotoxin pathway directs thymic Aire expressionRobert K Chin
Department of Pathology and Committee in Immunology, The University of Chicago, Chicago, Illinois 60637, USA
Nat Immunol 4:1121-7. 2003..These findings define the essential cross-talk between thymocytes and thymic stroma that is required for central tolerance...
- Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunityJuan E Moyron-Quiroz
Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, New York 12983, USA
Nat Med 10:927-34. 2004..Thus, iBALT functions as an inducible secondary lymphoid tissue for respiratory immune responses...
- Lymphotoxin pathway and Aire influences on thymic medullary epithelial cells are unconnectedEmily S Venanzi
Department of Medicine, Section on Immunology and Immunogenetics, Joslin Diabetes Center, Brigham and Women s Hospital, Boston, MA 02215, USA
J Immunol 179:5693-700. 2007..Aire were unaffected in medullary epithelial cells of mice lacking either lymphotoxin beta receptor or the lymphotoxin alpha-chain, and there was minimal overlap between the sets of genes controlled by Aire and lymphotoxin...
- Cloning and expression of murine lymphotoxin cDNAC B Li
J Immunol 138:4496-501. 1987..The cDNA was transcribed and was translated in vitro, and was expressed in COS-1 cells. This has resulted in the production of LT biological activity...
- Tumour necrosis factor and lymphotoxin genes map close to H-2D in the mouse major histocompatibility complexU Muller
Nature 325:265-7. 1987..Initially, we mapped the TNF genes the D or Qa region in the distal half of the mouse MHC. We then studied a gene cluster encompassing part of the D and Qa regions and found the TNF genes are located 70 kb proximal to the D gene...
- Absence of lymph nodes in lymphotoxin-alpha(LT alpha)-deficient mice is due to abnormal organ development, not defective lymphocyte migrationS Mariathasan
Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Inflamm 45:72-8. 1995Mice homozygous for a targeted null mutation of lymphotoxin-alpha (LT alpha) are born without lymph nodes (LN) or Peyer's patches (PP) and with altered splenic architecture...
- Characterization of the mouse lymphotoxin-beta geneP Lawton
Department of Inflammation and Immunology, Biogen, Cambridge, MA 02142
J Immunol 154:239-46. 1995..Northern analysis showed that this gene is expressed predominantly in lymphoid organs. The outlining of the complete mouse TNF locus will further studies of the relationship between these genes and immune function...
- Differential regulation of lymphotoxin (LT), lymphotoxin-beta (LT-beta), and TNF-alpha in murine T cell clones activated through the TCRI Millet
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520
J Immunol 152:4336-46. 1994..These differences suggest that the reason for the redundancy of LT, LT-beta, and TNF-alpha is their differential regulation rather than their functions...
- Unraveling function in the TNF ligand and receptor familiesB Beutler
Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235 9050
Science 264:667-8. 1994
- Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxinP De Togni
Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110
Science 264:703-7. 1994..Lymphocytes positive for immunoglobulin M are present in increased numbers in both the spleen and peripheral blood. These data suggest an essential role for LT in the normal development of peripheral lymphoid organs...
- Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infectionK Pfeffer
Department of Medical Biophysics, University of Toronto, Princess Margaret Hospital, Canada
Cell 73:457-67. 1993..In contrast, TNFRp55-deficient mice are severely impaired to clear L. monocytogenes and readily succumb to infection. Thus, the 55 kd TNFR plays a decisive role in the host's defense against microorganisms and their pathogenic factors...
- Tumour necrosis factor and lymphotoxin: molecular aspects and role in tissue-specific autoimmunityH Korner
Centenary Institute of Cancer Medicine and Cell Biology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
Immunol Cell Biol 74:465-72. 1996....
- Resistance to cerebral malaria in tumor necrosis factor-alpha/beta-deficient mice is associated with a reduction of intercellular adhesion molecule-1 up-regulation and T helper type 1 responseW Rudin
Swiss Tropical Institute, Basel, Switzerland
Am J Pathol 150:257-66. 1997..In the absence of TNF, ICAM-1 and nitric oxide up-regulation are reduced, and PbA infection fails to cause fatal CM...
- Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient miceP A Koni
Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Immunity 6:491-500. 1997b>Lymphotoxin alpha (LT alpha)-deficient mice revealed critical roles for LT alpha in lymphoid organogenesis, but it is not clear whether LT alpha functions through an LT alpha homotrimer (LT alpha3) or LT alpha/beta heterotrimers...
- Independent signals regulate development of primary and secondary follicle structure in spleen and mesenteric lymph nodeY X Fu
Division of Laboratory Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 94:5739-43. 1997..These data demonstrate that the signals that regulate the development of distinct T and B cell zones as well as the signals that regulate B cell activation to produce clusters of PNA+ cells differ between the spleen and LNs...
- Lymphotoxin-alpha-deficient and TNF receptor-I-deficient mice define developmental and functional characteristics of germinal centersM Matsumoto
First Department of Internal Medicine, Ehime University School of Medicine, Shigenobu, Japan
Immunol Rev 156:137-44. 1997Mice deficient in LT alpha (LT alpha-/-) lack lymph nodes and Peyer's patches...
- Tumor necrosis factor alpha and lymphotoxin alpha are not required for induction of acute experimental autoimmune encephalomyelitisK Frei
Department of Neurosurgery, University Hospital Zurich, CH 8091 Zurich, Switzerland
J Exp Med 185:2177-82. 1997..Tumor necrosis factor alpha (TNF-alpha) and lymphotoxin alpha (LT-alpha) are thought to be involved in the events leading to inflammatory demyelination in the central ..
- Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient miceM B Alimzhanov
Institute of Medical Microbiology, Immunology and Hygiene, Technical University of Munich, D 81675 Munich, Germany
Proc Natl Acad Sci U S A 94:9302-7. 1997..LTbeta form heterotrimers that are expressed on the surface of activated lymphocytes and natural killer cells; LTalpha homotrimers can be secreted as well...
- Characterization of lymphotoxin-alpha beta complexes on the surface of mouse lymphocytesJ L Browning
Department of Immunology, Biogen, Cambridge, MA 02142, USA
J Immunol 159:3288-98. 1997The lymphotoxin-alpha beta complex (LT alpha beta) is found on the surface of activated lymphocytes and binds to a specific receptor called the LT beta receptor (LT beta R)...
- Distinct roles of lymphotoxin alpha and the type I tumor necrosis factor (TNF) receptor in the establishment of follicular dendritic cells from non-bone marrow-derived cellsM Matsumoto
Center for Immunology and the Department of, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Exp Med 186:1997-2004. 1997In mice deficient in either lymphotoxin alpha (LT-alpha) or type I tumor necrosis factor receptor (TNFR-I), organized clusters of follicular dendritic cells (FDC) and germinal centers (GC) are absent from the spleen...
- Crucial role of tumor necrosis factor receptor 1 expression on nonhematopoietic cells for B cell localization within the splenic white pulpM Tkachuk
Molecular Immunology, Swiss Tropical Institute, Basel, CH 4002, Switzerland
J Exp Med 187:469-77. 1998..In contrast to lymphotoxin alpha-deficient mice (LTalpha-/-), bone marrow or fetal liver transplantation did not correct the abnormal ..
- Small bowel enteropathy: role of intraepithelial lymphocytes and of cytokines (IL-12, IFN-gamma, TNF) in the induction of epithelial cell death and renewalD Guy-Grand
INSERM U429, Hopital Necker Enfants Malades, Paris, France
Eur J Immunol 28:730-44. 1998..This insures the rapid epithelial renewal of the villi, which in turn helps maintain the functional integrity of the barrier...
- B lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin alpha-dependent fashionY X Fu
Department of Laboratory Medicine Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Exp Med 187:1009-18. 1998..dendritic cell (FDC) clusters and germinal centers (GCs) are absent from the peripheral lymphoid tissues of LTalpha-deficient (LTalpha-/-) mice...
- Lymph node genesis is induced by signaling through the lymphotoxin beta receptorP D Rennert
Department of Immunology and Inflammation, Biogen, Incorporated, Cambridge, Massachusetts 02142, USA
Immunity 9:71-9. 1998..Lymph nodes developed in LTalpha-/- mice treated in utero with agonist anti-LTbeta-R monoclonal antibody...
- Generation of splenic follicular structure and B cell movement in tumor necrosis factor-deficient miceM C Cook
Centenary Institute of Cancer Medicine and Cell Biology, Sydney, NSW, Australia 2050
J Exp Med 188:1503-10. 1998Secondary lymphoid tissue organogenesis requires tumor necrosis factor (TNF) and lymphotoxin alpha (LTalpha)...
- Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleenV N Ngo
Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California 94143, USA
J Exp Med 189:403-12. 1999..Here we report that BLC expression by follicular stromal cells is defective in TNF-, TNF receptor 1 (TNFR1)-, LTalpha- and LTbeta-deficient mice...
- Requirement for membrane lymphotoxin in natural killer cell developmentK Iizuka
Departments of Internal Medicine and Pathology, Howard Hughes Medical Institute, and Center for Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 96:6336-40. 1999..b>LTalpha-/- mice show marked reduction in splenic and BM NK and NK/T cell numbers and dramatically impaired NK and NK/T ..
- Lymphotoxin-beta-deficient mice show defective antiviral immunityD P Berger
Department of Neuropharmacology, Division of Virology, IMM 6, Department of Immunology, IMM 25, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, California, 92037, USA
Virology 260:136-47. 1999..These data indicate that the absence of LTbeta does not affect the intrinsic function of T lymphocytes or of dendritic cells but that the structural integrity of the spleen is strongly associated with generation of antiviral immunity...
- Involvement of distinct cellular compartments in the abnormal lymphoid organogenesis in lymphotoxin-alpha-deficient mice and alymphoplasia (aly) mice defined by the chimeric analysisM Matsumoto
First Department of Internal Medicine, School of Medicine, Ehime University, Japan
J Immunol 163:1584-91. 1999Both lymphotoxin-alpha (LTalpha)-deficient mice and alymphoplasia (aly) mice, a natural mutant strain, manifest a quite similar phenotype: lack of lymph nodes (LN) and Peyer's patches (PP), with disturbed spleen architecture...
- Mice with a targeted mutation in lymphotoxin-alpha exhibit enhanced tumor growth and metastasis: impaired NK cell development and recruitmentD Ito
Laboratory of Molecular Immunoregulation, Division of Basic Sciences, Science Applications International Corp Frederick, National Cancer Institute Frederic Cancer Research and Development Center, MD 21702, USA
J Immunol 163:2809-15. 1999..Although LTalpha is known to be expressed by NK cells as well as T and B lymphocytes, the requirement of LTalpha for NK cell ..
- The requirement of membrane lymphotoxin for the presence of dendritic cells in lymphoid tissuesQ Wu
Department of Pathology, The University of Chicago, Chicago, Illinois 60637, USA
J Exp Med 190:629-38. 1999..However, LTbetaR(-/-) mice show reduced numbers of DCs, similar to the mice lacking membrane LT alpha/beta...
- Lymphoid neo-organogenesis: lymphotoxin's role in inflammation and developmentN H Ruddle
Yale University School of Medicine, New Haven, CT 06520 8034, USA
Immunol Res 19:119-25. 1999....
- Nonlymphocyte-derived tumor necrosis factor is required for induction of colitis in recombination activating gene (RAG)2(-/-) mice upon transfer of CD4(+)CD45RB(hi) T cellsN Corazza
Institute of Pathology, Division of Immunopathology, University of Bern, CH 3010 Bern, Switzerland
J Exp Med 190:1479-92. 1999..These results demonstrate the importance of TNF production by non-T cells of the colonic mucosa in the pathogenesis of colitis and provide direct evidence for a nonredundant role of TNF-alpha in this mouse model of colitis...
- TNF and lymphotoxin beta cooperate in the maintenance of secondary lymphoid tissue microarchitecture but not in the development of lymph nodesD V Kuprash
Laboratory of Molecular Immunology, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow State University, Russia
J Immunol 163:6575-80. 1999..Most lymphotoxin alpha (ltalpha)- and all lymphotoxin beta receptor (ltbetar)-deficient mice are completely devoid of lymph nodes (..
- BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesisS A Luther
Department of Microbiology and Immunology, University of California, San Francisco 94143, USA
Immunity 12:471-81. 2000..These findings establish that BLC is sufficient to activate a pathway of events leading to formation of organized lymphoid tissue...
- A chemokine-driven positive feedback loop organizes lymphoid folliclesK M Ansel
Department of Microbiology and Immunology, University of California San Francisco, 94143, USA
Nature 406:309-14. 2000..In germinal centres the feedback loop is overridden, with B-cell lymphotoxin alpha1beta2 expression being induced by a mechanism independent of BLC...
- Antigen persistence is required for somatic mutation and affinity maturation of immunoglobulinY Wang
Department of Pathology, The University of Chicago, Chicago 60637, USA
Eur J Immunol 30:2226-34. 2000..Thus, these data support a model in which prolonged availability of antigen is required for somatic mutation and affinity maturation, and FDC or adjuvants facilitate such processes by slowly releasing antigens...
- Signal via lymphotoxin-beta R on bone marrow stromal cells is required for an early checkpoint of NK cell developmentQ Wu
Department of Pathology and Neurology, University of Chicago, Chicago, IL 60637, USA
J Immunol 166:1684-9. 2001..Lymphotoxin-alpha (LTalpha)(-/-) and LTbetaR(-/-) mice show a severe systemic reduction of NK cells, which provides an excellent model to ..
- Secreted lymphotoxin-alpha is essential for the control of an intracellular bacterial infectionD R Roach
Centenary Institute of Cancer Medicine and Cell Biology, Newtown NSW 2042, Australia
J Exp Med 193:239-46. 2001..To overcome the lack of peripheral lymph nodes in LTalpha-/- and LTbeta-/- mice, bone marrow chimeric mice were constructed...
- Essential role of lymph nodes in contact hypersensitivity revealed in lymphotoxin-alpha-deficient miceP D Rennert
Department of Immunology and Inflammation, Biogen, Incorporated, 14 Cambridge Center, Cambridge, MA 02142, USA
J Exp Med 193:1227-38. 2001....
- Generation of experimental allergic airways inflammation in the absence of draining lymph nodesB U Gajewska
Department of Pathology and Molecular Medicine, and Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
J Clin Invest 108:577-83. 2001..We executed this protocol in wild-type (WT) and lymphotoxin-alpha-deficient mice (LTalpha-KO) mice, which are devoid of lymph nodes (LNs) and possess rudimentary spleen structures...
- Splenic T zone development is B cell dependentV N Ngo
Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA
J Exp Med 194:1649-60. 2001..Introduction of a B cell specific LTalpha transgene on to the LTalpha-deficient background restored splenic CCL21 and gp38 expression, DC numbers, and T ..
- Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestineHiromasa Hamada
Department of Microbiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
J Immunol 168:57-64. 2002..Neither ILF nor PP are detectable in lymphotoxin alpha(-/-) and aly/aly mice that retain well-developed cryptopatches (CP) and thymus-independent subsets of ..
- Cutting edge: organogenesis of nasal-associated lymphoid tissue (NALT) occurs independently of lymphotoxin-alpha (LT alpha) and retinoic acid receptor-related orphan receptor-gamma, but the organization of NALT is LT alpha dependentAllen Harmsen
Department of Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
J Immunol 168:986-90. 2002..we found that NALT was formed in the absence of CD4+CD3- cells, which are thought to be the embryonic source of LTalpha. However, we also found that NALT of LTalpha-/- animals was disorganized and lymphopenic, suggesting that the ..
- Signaling via LTbetaR on the lamina propria stromal cells of the gut is required for IgA productionHyung Sik Kang
Department of Pathology and Committee on Immunology, The University of Chicago, 5841 S Maryland, Chicago, IL 60637, USA
Nat Immunol 3:576-82. 2002..Consistently, lymphoid tissue chemokines and adhesion molecules were reduced within the LP of LTalpha(-/-) and LTbetaR(-/-) mice...
- Membrane lymphotoxin contributes to anti-leishmanial immunity by controlling structural integrity of lymphoid organsPatricia Wilhelm
Institut fur Klinische Mikrobiologie, Immunologie und Hygiene der Universität Erlangen Nürnberg, Erlangen, Germany
Eur J Immunol 32:1993-2003. 2002..LTbeta-/-) and compared it to a unique series of LTalpha-, TNF- and TNF/LTalpha-gene-targeted mice on an identical genetic background (B6.LTalpha-/-, B6...
- Lymphotoxin is required for maintaining physiological levels of serum IgE that minimizes Th1-mediated airway inflammationHyung Sik Kang
Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
J Exp Med 198:1643-52. 2003..Lymphotoxin-deficient alpha (LTalpha-/-) mice exhibit increased airway inflammation, paradoxically accompanied by diminished levels of IgE and reduced ..
- Intestinal villous M cells: an antigen entry site in the mucosal epitheliumMyoung Ho Jang
Department of Mucosal Immunology, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
Proc Natl Acad Sci U S A 101:6110-5. 2004..lymphoid tissue (GALT)]-null mice, such as in utero lymphotoxin beta receptor (LTbetaR)-Ig-treated, lymphotoxin alpha (LTalpha)(-/-), tumor necrosis factor/LTalpha(-/-), and inhibition of differentiation 2 (Id2)(-/-) mice...
- Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cellsGerard Eberl
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
Science 305:248-51. 2004..Our results suggest that intestinal RORgammat+ cells are local organizers of mucosal lymphoid tissue...
- Intestinal cryptopatch formation in mice requires lymphotoxin alpha and the lymphotoxin beta receptorRebekah T Taylor
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
J Immunol 173:7183-9. 2004..In this study, we assessed the contributions of LTalpha and LTbetaR to the development of cryptopatches (CP), aggregates of T cell precursors in the mouse small ..
- Lymphotoxin plays a crucial role in the development and function of nasal-associated lymphoid tissue through regulation of chemokines and peripheral node addressinXiaoyan Ying
Yale University School of Medicine, Department of Epidemiology and Public Health, 60 College St, P O Box 208034, New Haven, CT 06520 8034, USA
Am J Pathol 166:135-46. 2005....
- Intrinsic lymphotoxin-beta receptor requirement for homeostasis of lymphoid tissue dendritic cellsKenji Kabashima
Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, California 94143, USA
Immunity 22:439-50. 2005..B cells are a key source of LT alpha 1 beta 2 for splenic DC homeostasis, and transgenic overexpression of LT alpha 1 beta 2 on B cells leads to ..
- Independent protective effects for tumor necrosis factor and lymphotoxin alpha in the host response to Listeria monocytogenes infectionD R Roach
Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag No 6, Newtown, NSW 2042, Australia
Infect Immun 73:4787-92. 2005..in resistance to Listeria monocytogenes infection is well established, the roles of the related cytokines lymphotoxin alpha (LTalpha) and lymphotoxin beta (LTbeta) are unknown...
- Function of CD4+CD3- cells in relation to B- and T-zone stroma in spleenMi Yeon Kim
Medical Research Council, Centre for Immune Regulation, Institute for Biomedical Research, Birmingham Medical School, UK
Blood 109:1602-10. 2007..CD4+CD3- cells express high levels of LTalpha, LTbeta, and tumor necrosis factor (TNF) alpha, which are the ligands for the LTbeta receptor and TNFR1 expressed ..
- Naive recirculating B cells mature simultaneously in the spleen and bone marrowAnnaiah Cariappa
Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
Blood 109:2339-45. 2007..B-cell maturation in the bone marrow was obtained from analyses of transitional B cells in splenectomized lymphotoxin alpha-deficient mice that lack all secondary lymphoid organs...
- Murine cerebral malaria development is independent of toll-like receptor signalingDieudonnée Togbe
Molecular Immunology and Embryology, Centre National de la Recherche Scientifique, and University of Orleans, Transgenose Institute, Orleans, France
Am J Pathol 170:1640-8. 2007..In contrast to lymphotoxin alpha-deficient mice, which are resistant to CM, all TLR-deficient mice were as sensitive to fatal CM development ..
- RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medullaSimona W Rossi
Medical Research Council Centre for Immune Regulation, Institute for Biomedical Research, University of Birmingham, B15 2TT Birmingham, UK
J Exp Med 204:1267-72. 2007..Collectively, our data reveal cellular and molecular mechanisms leading to the generation of Aire(+) mTECs and highlight a previously unrecognized role for CD4(+)3(-)RANKL(+) inducer cells in intrathymic self-tolerance...
- Lymphotoxin a-dependent and -independent signals regulate stromal organizer cell homeostasis during lymph node organogenesisAndrea White
Division of Immunity and Infection, Instiute for BioMedical Research Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, United Kingdom
Blood 110:1950-9. 2007..In addition, analysis of the lymph node anlagen in normal and lymphotoxin a (LTa)-deficient embryos shows that LTa-mediated signaling is required to sustain proliferation and survival of stromal ..
- The role of lymphoid tissue inducer cells in splenic white pulp developmentDavid R Withers
MRC Centre for Immune Regulation, Institute for Biomedical Research, Birmingham Medical School, Birmingham, UK
Eur J Immunol 37:3240-5. 2007..Transfer experiments reconstituting RAG(-/-) mice with either WT or LTalpha(-/-) splenocytes demonstrated that lymphocyte expression of LT was not essential for the organisation of a ..
- Separation of splenic red and white pulp occurs before birth in a LTalphabeta-independent mannerMark F R Vondenhoff
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
J Leukoc Biol 84:152-61. 2008..The postnatal development of the splenic white pulp, involving the influx of T cells, depends on LTalpha1beta2 expressed by B cells...
- Overexpression of lymphotoxin in T cells induces fulminant thymic involutionMathias Heikenwalder
Institute of Neuropathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
Am J Pathol 172:1555-70. 2008..Multiple lines of transgenic Ltalphabeta and Ltalpha mice show such a phenotype, which was not observed on overexpression of LTbeta alone...
- Omental milky spots develop in the absence of lymphoid tissue-inducer cells and support B and T cell responses to peritoneal antigensJavier Rangel-Moreno
Division of Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY 14642, USA
Immunity 30:731-43. 2009..These results indicate that the milky spots of the omentum function as unique secondary lymphoid organs that promote immunity to peritoneal antigens...
- Targeted depletion of lymphotoxin-alpha-expressing TH1 and TH17 cells inhibits autoimmune diseaseEugene Y Chiang
Department of Immunology, South San Francisco, California, USA
Nat Med 15:766-73. 2009..These data indicate that depleting LT-alpha-expressing lymphocytes with LT-alpha-specific mAb may be beneficial in the treatment of autoimmune disease...
- Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulationSerge A van de Pavert
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
Nat Immunol 10:1193-9. 2009..Therefore, our data show that the initiation of lymph node development is controlled by RA-mediated expression of CXCL13 and suggest that RA may be provided by adjacent neurons...
- Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunityTakahiro Nagatake
Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo 108 8639, Japan
J Exp Med 206:2351-64. 2009..Thus, TALT shares immunological features with MALT but has a distinct tissue genesis mechanism and plays a key role in ocular immunity...
- Characterization of several new MHC congenic strainsA C Walsh
Department of Microbiology and Immunology, Albany Medical College, NY
Immunogenetics 33:290-3. 1991
- Mouse lymphotoxin and tumor necrosis factor: structural analysis of the cloned genes, physical linkage, and chromosomal positionS M Gardner
J Immunol 139:476-83. 1987..Comparison of the 5' flanking sequence of LT to a number of genes that are specifically expressed in activated T cells reveals a number of conserved sequences that may play a role in control of these genes...
- Induction of tumor necrosis factor-alpha and -beta and interferon-gamma mRNA by interleukin 2 in murine lymphocytic cell linesD Weil
Laboratoire d Oncologie Moleculaire, CNRS UA 1158, Institut Gustave Roussy, Villejuif, France
Oncogene Res 3:409-14. 1988..As activated T lymphocytes express receptors to both TNF and IFN-gamma, our observation raises the possibility that these lymphokines are involved in an autocrine regulation of cytotoxic lymphocytes proliferation...
- Recombination in the class III region of the mouse major histocompatibility complexM Yoshino
Mammalian Genetics Laboratory, National Institute of Genetics, Mishima, Japan
Immunogenetics 40:280-6. 1994..The results gave the gene order of Eb-61.1-Int3-Tnx-Cyp21/C4-Bf-Hsp68c-D17Mit13+ ++-Tnfa/Tnfb-D. The crossover sites in 40 of the 79 recombinants were confined within the Eb/Int3:Tnx/Cyp21 interval...
- An evolutionary and functional approach to the TNF receptor/ligand familyB Beutler
Howard Hughes Medical Institute, Dallas, Texas 75235 9050
Ann N Y Acad Sci 730:118-33. 1994
- Distribution and kinetics of superantigen-induced cytokine gene expression in mouse spleenM Bette
First Department of Medicine, University of Mainz, Germany
J Exp Med 178:1531-9. 1993..These data show that nonphagocytic cells are the essential superantigen-presenting cells in vivo and indicate that at least part of the pathogenetic TNF-alpha is T cell derived...
- Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factorR G Goodwin
Immunex Research and Development Corporation, Seattle, Washington 98101
Cell 73:447-56. 1993..Biological characterization indicates that the cloned ligand induces the proliferation of costimulated T cells and enhances the generation of cytolytic T cells...
- High-resolution comparative mapping of mouse chromosome 17H Himmelbauer
Department of Molecular Biology, Princeton University, New Jersey 08544 1014
Genomics 17:110-20. 1993..We present the localization of four new DNA markers and determined map positions for 10 other loci, which previously had been assigned to intervals of the t complex only through the study of partial t haplotype chromosomes...
- Expression and function of the early activation antigen CD69 in murine macrophagesR Marzio
Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
J Leukoc Biol 62:349-55. 1997..These results suggest that CD69 is an activation antigen for murine macrophages and may serve as a signaling receptor for an as yet uncharacterized ligand...
- Control of nitric oxide production by endogenous TNF-alpha in mouse retinal pigmented epithelial and Muller glial cellsO Goureau
Developpement, Vieillissement et Pathologie de la Retine, U450 INSERM, Association C Bernard, Paris, France
Biochem Biophys Res Commun 240:132-5. 1997..TNF alpha), we have investigated in vitro the production of NO in retinal cells from mice deficient in Lymphotoxin alpha (LT alpha)/TNF alpha...
- Increased susceptibility of TNF-alpha lymphotoxin-alpha double knockout mice to systemic candidiasis through impaired recruitment of neutrophils and phagocytosis of Candida albicansM G Netea
Department of Medicine, University Hospital Nijmegen, The Netherlands
J Immunol 163:1498-505. 1999..albicans...
- Lymphotoxin-alpha-deficient mice can clear a productive infection with murine gammaherpesvirus 68 but fail to develop splenomegaly or lymphocytosisB J Lee
La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
J Virol 74:2786-92. 2000..Lymphotoxin- alpha-deficient (LTalpha(-/-)) mice have no lymph nodes and have disrupted splenic architecture...
- VIRUSES AND AUTOIMMUNE DISEASEMichael Oldstone; Fiscal Year: 2001..The second order of business is to determine the role of "self" (islet-cell) antigens other than the initial triggering viral antigen in the pathogenetic process leading to and determine their role in IDDM. ..
- STUDIES OF A NEW MYELIN GENE THAT CAUSES CNS DISEASEMichael Oldstone; Fiscal Year: 2001..Their studies in rodents combined with those of their collaborator, Dr. Martin, should begin to characterize the role played by MONP in neurologic disease. ..
- Pathogenesis Studies in Scrapie (TSE Diseases)Michael Oldstone; Fiscal Year: 2003..This model should be useful to study pathophysiology of CWD as well as probing CWD strain differences. ..
- ORPHAN NUCLEAR RORgammat IN THYMOCYTE DIFFERENTIATIONYou Wen He; Fiscal Year: 2006..In addition, results from this application will also provide insights for the role of ROR-gamma-t in tumorigenesis. ..
- MEASLES VIRUS STUDIES IN A TRANSGENIC MODELMichael Oldstone; Fiscal Year: 2007..abstract_text> ..
- Extracellular Matrix Protein in Innate ImmunityYou Wen He; Fiscal Year: 2007..Results from this proposal will provide novel insights on the mechanisms of the innate immune response and may have implication for clinical treatment of septic shock and other microbe caused diseases. [unreadable] [unreadable]..
- Pattern Recognition Molecule Mindin As AdjuvantYou Wen He; Fiscal Year: 2007..Third, Mindin fused DNA plasmids will be examined for their efficacy in protecting influenza virus infection. [unreadable] [unreadable]..
- Therapeutics to Prevent/Treat Lassa Fever VirusMichael B Oldstone; Fiscal Year: 2010..We anticipate making a significant contribution to drug development to treat these BSL-4 agents. ..
- TERTIARY LYMPHOID ORGANS IN TYPE I DIABETES MELLITUSNANCY RUDDLE; Fiscal Year: 2003..Mice transgenic for lymphotoxin (LTalpha; TNFbeta) under the control of the insulin promoter (RIPLT mice) express the transgene in the pancreas and kidney ..
- The role of TNF receptor family in intestinal GVHDGERI BROWN; Fiscal Year: 2004..abstract_text> ..
- Viruses and DiabetesMichael Oldstone; Fiscal Year: 2005....
- LYMPHOTOXIN: REGULATION AND BIOLOGICAL SIGNIFICANCENANCY RUDDLE; Fiscal Year: 2006..Differences between LTalpha and LTBeta with regard to the NALT development and function will be studied as will the temporal and kinetic ..
- Aging Disease--Prion/Transgenic/Immunologic StudiesMichael Oldstone; Fiscal Year: 2008..Lastly, Jose Criado will continue his electrophysiology and behavioral studies on the normal function of PrP and on its aberrations during TSE disease. ..
- Neural-Immune Interacations: Pathology and Molecular Mechanisms of RepairNANCY RUDDLE; Fiscal Year: 2008..The ultimate goal is to provide prevention and treatment of diseases that involve interactions between these two systems. [unreadable] [unreadable] [unreadable] [unreadable]..
- Arenavirus Receptor-Structure/Function StudiesMichael B Oldstone; Fiscal Year: 2010..These findings have relevance for biodefense of several viruses including LFV. ..
- LYMPHOTOXIN AND LYMPHOID NEOGENESISNancy H Ruddle; Fiscal Year: 2010..Directed over expression of lymphotoxin (LT) (either LTa or LTab) results in ectopic lymphoid aggregates with the characteristics of lymphoid organs...