Lta

Summary

Gene Symbol: Lta
Description: lymphotoxin A
Alias: LT-[a], LT-alpha, LT[a], LTalpha, Ltx, TNF-beta, TNFSF1, Tnfb, Tnfsf1b, Tnlg1e, hlb382, lymphotoxin-alpha, TNF beta, tumor necrosis factor ligand 1e, tumor necrosis factor ligand superfamily member 1
Species: mouse

Top Publications

  1. ncbi Expression of tumor necrosis factor and c-fos genes in peritoneal macrophages of hypothyroid mice
    W K Liu
    Department of Anatomy, Faculty of Medicine, Chinese University of Hong Kong, Shatin, N T
    Inflammation 17:217-25. 1993
  2. ncbi Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2
    Y Yokota
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Gottingen, Germany
    Nature 397:702-6. 1999
  3. ncbi An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells
    Gerard Eberl
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Nat Immunol 5:64-73. 2004
  4. ncbi Alternate mucosal immune system: organized Peyer's patches are not required for IgA responses in the gastrointestinal tract
    M Yamamoto
    Department of Clinical Pathology, Nihon University School of Dentistry at Matsudo, Chiba, Japan
    J Immunol 164:5184-91. 2000
  5. ncbi Lymphotoxin-alpha-deficient mice make delayed, but effective, T and B cell responses to influenza
    Frances E Lund
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 169:5236-43. 2002
  6. ncbi A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria
    A J MacPherson
    Institute of Experimental Immunology, Universitatsspital, Schmelzbergstrasse 12, CH8091, Zurich, Switzerland
    Science 288:2222-6. 2000
  7. pmc Differentiation of follicular dendritic cells and full antibody responses require tumor necrosis factor receptor-1 signaling
    M Le Hir
    Swiss Institute of Technology, Institute of Toxicology, Schwerzenbach, Switzerland
    J Exp Med 183:2367-72. 1996
  8. pmc Challenging cytokine redundancy: inflammatory cell movement and clinical course of experimental autoimmune encephalomyelitis are normal in lymphotoxin-deficient, but not tumor necrosis factor-deficient, mice
    D Sean Riminton
    Centenary Institute of Cancer Medicine and Cell Biology, Sydney, New South Wales 2050, Australia
    J Exp Med 187:1517-28. 1998
  9. ncbi Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue
    H Korner
    Centenary Institute of Cancer Medicine and Cell Biology, Sydney, Australia
    Eur J Immunol 27:2600-9. 1997
  10. pmc Locally up-regulated lymphotoxin alpha, not systemic tumor necrosis factor alpha, is the principle mediator of murine cerebral malaria
    Christian R Engwerda
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom
    J Exp Med 195:1371-7. 2002

Research Grants

  1. VIRUSES AND AUTOIMMUNE DISEASE
    Michael Oldstone; Fiscal Year: 2001
  2. STUDIES OF A NEW MYELIN GENE THAT CAUSES CNS DISEASE
    Michael Oldstone; Fiscal Year: 2001
  3. Pathogenesis Studies in Scrapie (TSE Diseases)
    Michael Oldstone; Fiscal Year: 2003
  4. ORPHAN NUCLEAR RORgammat IN THYMOCYTE DIFFERENTIATION
    You Wen He; Fiscal Year: 2006
  5. MEASLES VIRUS STUDIES IN A TRANSGENIC MODEL
    Michael Oldstone; Fiscal Year: 2007
  6. Extracellular Matrix Protein in Innate Immunity
    You Wen He; Fiscal Year: 2007
  7. Pattern Recognition Molecule Mindin As Adjuvant
    You Wen He; Fiscal Year: 2007
  8. Therapeutics to Prevent/Treat Lassa Fever Virus
    Michael B Oldstone; Fiscal Year: 2010
  9. TERTIARY LYMPHOID ORGANS IN TYPE I DIABETES MELLITUS
    NANCY RUDDLE; Fiscal Year: 2003
  10. The role of TNF receptor family in intestinal GVHD
    GERI BROWN; Fiscal Year: 2004

Scientific Experts

Detail Information

Publications133 found, 100 shown here

  1. ncbi Expression of tumor necrosis factor and c-fos genes in peritoneal macrophages of hypothyroid mice
    W K Liu
    Department of Anatomy, Faculty of Medicine, Chinese University of Hong Kong, Shatin, N T
    Inflammation 17:217-25. 1993
    ..These results indicate that the reduction in signal transduction and in the production of antitumor molecules may cause the poor defense ability of hypothyroid animals...
  2. ncbi Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2
    Y Yokota
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Gottingen, Germany
    Nature 397:702-6. 1999
    ..Our results indicate that Id2 has an essential role in the generation of peripheral lymphoid organs and NK cells...
  3. ncbi An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells
    Gerard Eberl
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Nat Immunol 5:64-73. 2004
    ..This early LTi cell-mediated activation of lymph node and Peyer's patch mesenchyma forms the necessary platform for the subsequent development of mature lymphoid tissues...
  4. ncbi Alternate mucosal immune system: organized Peyer's patches are not required for IgA responses in the gastrointestinal tract
    M Yamamoto
    Department of Clinical Pathology, Nihon University School of Dentistry at Matsudo, Chiba, Japan
    J Immunol 164:5184-91. 2000
    ..Further, organized Peyer's patches are not a strict requirement for induction of mucosal IgA Ab responses in the gastrointestinal tract...
  5. ncbi Lymphotoxin-alpha-deficient mice make delayed, but effective, T and B cell responses to influenza
    Frances E Lund
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 169:5236-43. 2002
    Lymphotoxin-alpha(-/-) (LTalpha(-/-)) mice are thought to be unable to generate effective T and B cell responses. This is attributed to the lack of lymph nodes and the disrupted splenic architecture of these mice...
  6. ncbi A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria
    A J MacPherson
    Institute of Experimental Immunology, Universitatsspital, Schmelzbergstrasse 12, CH8091, Zurich, Switzerland
    Science 288:2222-6. 2000
    ....
  7. pmc Differentiation of follicular dendritic cells and full antibody responses require tumor necrosis factor receptor-1 signaling
    M Le Hir
    Swiss Institute of Technology, Institute of Toxicology, Schwerzenbach, Switzerland
    J Exp Med 183:2367-72. 1996
    Using mice double deficient for tumor necrosis factor (TNF) and lymphotoxin alpha (LT alpha), we demonstrated that TNF and/or LT alpha are necessary for development of a normal splenic microarchitecture and for isotype switch after ..
  8. pmc Challenging cytokine redundancy: inflammatory cell movement and clinical course of experimental autoimmune encephalomyelitis are normal in lymphotoxin-deficient, but not tumor necrosis factor-deficient, mice
    D Sean Riminton
    Centenary Institute of Cancer Medicine and Cell Biology, Sydney, New South Wales 2050, Australia
    J Exp Med 187:1517-28. 1998
    ..The contribution of LT to experimental autoimmune encephalomyelitis (EAE) was examined using TNF/LTalpha-/- mice, TNF-/- mice, and a new LTalpha-/- line described here...
  9. ncbi Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue
    H Korner
    Centenary Institute of Cancer Medicine and Cell Biology, Sydney, Australia
    Eur J Immunol 27:2600-9. 1997
    ..for the pro-inflammatory cytokines tumor necrosis factor (TNF) and lymphotoxin (LT) were characterized in TNF/LT alpha -/- and TNF -/- mice established by direct gene targeting of C57BL/6 ES cells...
  10. pmc Locally up-regulated lymphotoxin alpha, not systemic tumor necrosis factor alpha, is the principle mediator of murine cerebral malaria
    Christian R Engwerda
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom
    J Exp Med 195:1371-7. 2002
    ..In contrast, the role of the related cyto-kine lymphotoxin alpha (LTalpha) in CM has been overlooked...
  11. ncbi The lymphotoxin beta receptor is critically involved in controlling infections with the intracellular pathogens Mycobacterium tuberculosis and Listeria monocytogenes
    Stefan Ehlers
    Division of Molecular Infection Biology, Research Center Borstel, Borstel, Germany
    J Immunol 170:5210-8. 2003
    ..When mice deficient in LT alpha or LT beta were challenged intranasally with Mycobacterium tuberculosis, they showed a significant increase in ..
  12. ncbi Role of CXC chemokine ligand 13, CC chemokine ligand (CCL) 19, and CCL21 in the organization and function of nasal-associated lymphoid tissue
    Javier Rangel-Moreno
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 175:4904-13. 2005
    ..Unlike other lymphoid organs, NALT develops independently of lymphotoxin-alpha (LTalpha)...
  13. ncbi Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells
    Dominik Meier
    Division of Developmental Immunology, Center for Biomedicine, Department of Clinical and Biological Sciences DKBW, University of Basel, CH 4058 Basel, Switzerland
    Immunity 26:643-54. 2007
    ..Therefore, by controlling LTi cell numbers, IL-7 can regulate the formation of both normal and ectopic lymphoid organs...
  14. ncbi Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness
    T A Banks
    Department of Microbiology, University of Tennessee, Knoxville 37996, USA
    J Immunol 155:1685-93. 1995
    ..These data illustrate the utility of this mouse model as a system for understanding lymphoid organ development and its effects on immune responsiveness...
  15. ncbi Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers
    M Matsumoto
    Center for Immunology and Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 271:1289-91. 1996
    ..Germinal center formation was restored in LT-alpha-deficient mice by transplantation of normal bone marrow, indicating that the LT-alpha-expressing cells required to establish this lymphoid structure are derived from bone marrow...
  16. ncbi Multiple immune abnormalities in tumor necrosis factor and lymphotoxin-alpha double-deficient mice
    H P Eugster
    Swiss Federal Institute of Technology, Institute of Toxicology, Schorenstasse 16, 8603 Schwerzenbach, Switzerland
    Int Immunol 8:23-36. 1996
    ..factor (TNF) and lymphotoxin (LT)-alpha in the development and function of the immune system, the Tnf and Ltalpha genes were simultaneously inactivated in mice by homologous recombination...
  17. ncbi Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice
    M Matsumoto
    Center for Immunology and Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 382:462-6. 1996
    ..Mice deficient in lymphotoxin-alpha (LT alpha-/- mice) have no lymph nodes or Peyer's patches, and fail to form germinal centres in the spleen...
  18. pmc Defective Peyer's patch organogenesis in mice lacking the 55-kD receptor for tumor necrosis factor
    B Neumann
    Institute for Medical Microbiology and Hygiene, Technical University of Munich, Germany
    J Exp Med 184:259-64. 1996
    b>Lymphotoxin alpha (LT-alpha) may form secreted homotrimers binding to p55 and p75 tumor necrosis factor (TNF) receptors or cell surface-bound heterotrimers with LT-beta that interact with the LT-beta receptor...
  19. ncbi Lack of type 2 T cell-independent B cell responses and defect in isotype switching in TNF-lymphotoxin alpha-deficient mice
    B Ryffel
    Institute of Pathology, University of Basel, Switzerland
    J Immunol 158:2126-33. 1997
    ..Our previous studies had shown that TNF-LT alpha double-deficient mice have defective IgM and IgG primary Ab responses to the T cell-dependent (TD) Ag SRBC...
  20. pmc Lymphotoxin-alpha (LTalpha) supports development of splenic follicular structure that is required for IgG responses
    Y X Fu
    Department of Laboratory Medicine and Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Exp Med 185:2111-20. 1997
    b>LTalpha-deficient (LTalpha-/-) mice show altered splenic microarchitecture. This includes loss of normal B cell-T cell compartmentalization, of follicular dendritic cell (FDC) clusters, and of ability to form germinal centers (GC)...
  21. ncbi The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues
    A Fütterer
    Institute of Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, Germany
    Immunity 9:59-70. 1998
    ..Since LTbetaR-/- mice exhibit distinct defects when compared to LTalpha-/- and LTbeta-/- mice, it is suggested that the LTbetaR integrates signals from other TNF family members...
  22. ncbi Tumor necrosis factor and the p55TNF receptor are required for optimal development of the marginal sinus and for migration of follicular dendritic cell precursors into splenic follicles
    M Pasparakis
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, 115 21, Greece
    Cell Immunol 201:33-41. 2000
    ....
  23. ncbi Initiation of NALT organogenesis is independent of the IL-7R, LTbetaR, and NIK signaling pathways but requires the Id2 gene and CD3(-)CD4(+)CD45(+) cells
    Satoshi Fukuyama
    Department of Mucosal Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    Immunity 17:31-40. 2002
    ....
  24. ncbi Distinct contributions of TNF and LT cytokines to the development of dendritic cells in vitro and their recruitment in vivo
    Koichiro Abe
    Laboratory of Molecular Immunoregulation, Center for Cancer Research and Basic Research Program, SAIC Frederick, National Cancer Institute, MD 21702, USA
    Blood 101:1477-83. 2003
    TNF/LTalpha/LTbeta (tumor necrosis factor/lymphotoxin-alpha/lymphotoxin-beta) triple knockout (KO) mice show a significant reduction of dendritic cell (DC) number in the spleen, presumably due to defective recruitment and/or production...
  25. ncbi Lymphotoxin pathway directs thymic Aire expression
    Robert K Chin
    Department of Pathology and Committee in Immunology, The University of Chicago, Chicago, Illinois 60637, USA
    Nat Immunol 4:1121-7. 2003
    ..These findings define the essential cross-talk between thymocytes and thymic stroma that is required for central tolerance...
  26. ncbi Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity
    Juan E Moyron-Quiroz
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, New York 12983, USA
    Nat Med 10:927-34. 2004
    ..Thus, iBALT functions as an inducible secondary lymphoid tissue for respiratory immune responses...
  27. ncbi Lymphotoxin pathway and Aire influences on thymic medullary epithelial cells are unconnected
    Emily S Venanzi
    Department of Medicine, Section on Immunology and Immunogenetics, Joslin Diabetes Center, Brigham and Women s Hospital, Boston, MA 02215, USA
    J Immunol 179:5693-700. 2007
    ..Aire were unaffected in medullary epithelial cells of mice lacking either lymphotoxin beta receptor or the lymphotoxin alpha-chain, and there was minimal overlap between the sets of genes controlled by Aire and lymphotoxin...
  28. ncbi Cloning and expression of murine lymphotoxin cDNA
    C B Li
    J Immunol 138:4496-501. 1987
    ..The cDNA was transcribed and was translated in vitro, and was expressed in COS-1 cells. This has resulted in the production of LT biological activity...
  29. ncbi Tumour necrosis factor and lymphotoxin genes map close to H-2D in the mouse major histocompatibility complex
    U Muller
    Nature 325:265-7. 1987
    ..Initially, we mapped the TNF genes the D or Qa region in the distal half of the mouse MHC. We then studied a gene cluster encompassing part of the D and Qa regions and found the TNF genes are located 70 kb proximal to the D gene...
  30. ncbi Absence of lymph nodes in lymphotoxin-alpha(LT alpha)-deficient mice is due to abnormal organ development, not defective lymphocyte migration
    S Mariathasan
    Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Inflamm 45:72-8. 1995
    Mice homozygous for a targeted null mutation of lymphotoxin-alpha (LT alpha) are born without lymph nodes (LN) or Peyer's patches (PP) and with altered splenic architecture...
  31. ncbi Characterization of the mouse lymphotoxin-beta gene
    P Lawton
    Department of Inflammation and Immunology, Biogen, Cambridge, MA 02142
    J Immunol 154:239-46. 1995
    ..Northern analysis showed that this gene is expressed predominantly in lymphoid organs. The outlining of the complete mouse TNF locus will further studies of the relationship between these genes and immune function...
  32. ncbi Differential regulation of lymphotoxin (LT), lymphotoxin-beta (LT-beta), and TNF-alpha in murine T cell clones activated through the TCR
    I Millet
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520
    J Immunol 152:4336-46. 1994
    ..These differences suggest that the reason for the redundancy of LT, LT-beta, and TNF-alpha is their differential regulation rather than their functions...
  33. ncbi Unraveling function in the TNF ligand and receptor families
    B Beutler
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235 9050
    Science 264:667-8. 1994
  34. ncbi Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin
    P De Togni
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110
    Science 264:703-7. 1994
    ..Lymphocytes positive for immunoglobulin M are present in increased numbers in both the spleen and peripheral blood. These data suggest an essential role for LT in the normal development of peripheral lymphoid organs...
  35. ncbi Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection
    K Pfeffer
    Department of Medical Biophysics, University of Toronto, Princess Margaret Hospital, Canada
    Cell 73:457-67. 1993
    ..In contrast, TNFRp55-deficient mice are severely impaired to clear L. monocytogenes and readily succumb to infection. Thus, the 55 kd TNFR plays a decisive role in the host's defense against microorganisms and their pathogenic factors...
  36. ncbi Tumour necrosis factor and lymphotoxin: molecular aspects and role in tissue-specific autoimmunity
    H Korner
    Centenary Institute of Cancer Medicine and Cell Biology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Immunol Cell Biol 74:465-72. 1996
    ....
  37. pmc Resistance to cerebral malaria in tumor necrosis factor-alpha/beta-deficient mice is associated with a reduction of intercellular adhesion molecule-1 up-regulation and T helper type 1 response
    W Rudin
    Swiss Tropical Institute, Basel, Switzerland
    Am J Pathol 150:257-66. 1997
    ..In the absence of TNF, ICAM-1 and nitric oxide up-regulation are reduced, and PbA infection fails to cause fatal CM...
  38. ncbi Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice
    P A Koni
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 6:491-500. 1997
    b>Lymphotoxin alpha (LT alpha)-deficient mice revealed critical roles for LT alpha in lymphoid organogenesis, but it is not clear whether LT alpha functions through an LT alpha homotrimer (LT alpha3) or LT alpha/beta heterotrimers...
  39. pmc Independent signals regulate development of primary and secondary follicle structure in spleen and mesenteric lymph node
    Y X Fu
    Division of Laboratory Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 94:5739-43. 1997
    ..These data demonstrate that the signals that regulate the development of distinct T and B cell zones as well as the signals that regulate B cell activation to produce clusters of PNA+ cells differ between the spleen and LNs...
  40. ncbi Lymphotoxin-alpha-deficient and TNF receptor-I-deficient mice define developmental and functional characteristics of germinal centers
    M Matsumoto
    First Department of Internal Medicine, Ehime University School of Medicine, Shigenobu, Japan
    Immunol Rev 156:137-44. 1997
    Mice deficient in LT alpha (LT alpha-/-) lack lymph nodes and Peyer's patches...
  41. pmc Tumor necrosis factor alpha and lymphotoxin alpha are not required for induction of acute experimental autoimmune encephalomyelitis
    K Frei
    Department of Neurosurgery, University Hospital Zurich, CH 8091 Zurich, Switzerland
    J Exp Med 185:2177-82. 1997
    ..Tumor necrosis factor alpha (TNF-alpha) and lymphotoxin alpha (LT-alpha) are thought to be involved in the events leading to inflammatory demyelination in the central ..
  42. pmc Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice
    M B Alimzhanov
    Institute of Medical Microbiology, Immunology and Hygiene, Technical University of Munich, D 81675 Munich, Germany
    Proc Natl Acad Sci U S A 94:9302-7. 1997
    ..LTbeta form heterotrimers that are expressed on the surface of activated lymphocytes and natural killer cells; LTalpha homotrimers can be secreted as well...
  43. ncbi Characterization of lymphotoxin-alpha beta complexes on the surface of mouse lymphocytes
    J L Browning
    Department of Immunology, Biogen, Cambridge, MA 02142, USA
    J Immunol 159:3288-98. 1997
    The lymphotoxin-alpha beta complex (LT alpha beta) is found on the surface of activated lymphocytes and binds to a specific receptor called the LT beta receptor (LT beta R)...
  44. pmc Distinct roles of lymphotoxin alpha and the type I tumor necrosis factor (TNF) receptor in the establishment of follicular dendritic cells from non-bone marrow-derived cells
    M Matsumoto
    Center for Immunology and the Department of, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Exp Med 186:1997-2004. 1997
    In mice deficient in either lymphotoxin alpha (LT-alpha) or type I tumor necrosis factor receptor (TNFR-I), organized clusters of follicular dendritic cells (FDC) and germinal centers (GC) are absent from the spleen...
  45. pmc Crucial role of tumor necrosis factor receptor 1 expression on nonhematopoietic cells for B cell localization within the splenic white pulp
    M Tkachuk
    Molecular Immunology, Swiss Tropical Institute, Basel, CH 4002, Switzerland
    J Exp Med 187:469-77. 1998
    ..In contrast to lymphotoxin alpha-deficient mice (LTalpha-/-), bone marrow or fetal liver transplantation did not correct the abnormal ..
  46. ncbi Small bowel enteropathy: role of intraepithelial lymphocytes and of cytokines (IL-12, IFN-gamma, TNF) in the induction of epithelial cell death and renewal
    D Guy-Grand
    INSERM U429, Hopital Necker Enfants Malades, Paris, France
    Eur J Immunol 28:730-44. 1998
    ..This insures the rapid epithelial renewal of the villi, which in turn helps maintain the functional integrity of the barrier...
  47. pmc B lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin alpha-dependent fashion
    Y X Fu
    Department of Laboratory Medicine Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Exp Med 187:1009-18. 1998
    ..dendritic cell (FDC) clusters and germinal centers (GCs) are absent from the peripheral lymphoid tissues of LTalpha-deficient (LTalpha-/-) mice...
  48. ncbi Lymph node genesis is induced by signaling through the lymphotoxin beta receptor
    P D Rennert
    Department of Immunology and Inflammation, Biogen, Incorporated, Cambridge, Massachusetts 02142, USA
    Immunity 9:71-9. 1998
    ..Lymph nodes developed in LTalpha-/- mice treated in utero with agonist anti-LTbeta-R monoclonal antibody...
  49. pmc Generation of splenic follicular structure and B cell movement in tumor necrosis factor-deficient mice
    M C Cook
    Centenary Institute of Cancer Medicine and Cell Biology, Sydney, NSW, Australia 2050
    J Exp Med 188:1503-10. 1998
    Secondary lymphoid tissue organogenesis requires tumor necrosis factor (TNF) and lymphotoxin alpha (LTalpha)...
  50. pmc Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen
    V N Ngo
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California 94143, USA
    J Exp Med 189:403-12. 1999
    ..Here we report that BLC expression by follicular stromal cells is defective in TNF-, TNF receptor 1 (TNFR1)-, LTalpha- and LTbeta-deficient mice...
  51. pmc Requirement for membrane lymphotoxin in natural killer cell development
    K Iizuka
    Departments of Internal Medicine and Pathology, Howard Hughes Medical Institute, and Center for Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 96:6336-40. 1999
    ..b>LTalpha-/- mice show marked reduction in splenic and BM NK and NK/T cell numbers and dramatically impaired NK and NK/T ..
  52. ncbi Lymphotoxin-beta-deficient mice show defective antiviral immunity
    D P Berger
    Department of Neuropharmacology, Division of Virology, IMM 6, Department of Immunology, IMM 25, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, California, 92037, USA
    Virology 260:136-47. 1999
    ..These data indicate that the absence of LTbeta does not affect the intrinsic function of T lymphocytes or of dendritic cells but that the structural integrity of the spleen is strongly associated with generation of antiviral immunity...
  53. ncbi Involvement of distinct cellular compartments in the abnormal lymphoid organogenesis in lymphotoxin-alpha-deficient mice and alymphoplasia (aly) mice defined by the chimeric analysis
    M Matsumoto
    First Department of Internal Medicine, School of Medicine, Ehime University, Japan
    J Immunol 163:1584-91. 1999
    Both lymphotoxin-alpha (LTalpha)-deficient mice and alymphoplasia (aly) mice, a natural mutant strain, manifest a quite similar phenotype: lack of lymph nodes (LN) and Peyer's patches (PP), with disturbed spleen architecture...
  54. ncbi Mice with a targeted mutation in lymphotoxin-alpha exhibit enhanced tumor growth and metastasis: impaired NK cell development and recruitment
    D Ito
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, Science Applications International Corp Frederick, National Cancer Institute Frederic Cancer Research and Development Center, MD 21702, USA
    J Immunol 163:2809-15. 1999
    ..Although LTalpha is known to be expressed by NK cells as well as T and B lymphocytes, the requirement of LTalpha for NK cell ..
  55. pmc The requirement of membrane lymphotoxin for the presence of dendritic cells in lymphoid tissues
    Q Wu
    Department of Pathology, The University of Chicago, Chicago, Illinois 60637, USA
    J Exp Med 190:629-38. 1999
    ..However, LTbetaR(-/-) mice show reduced numbers of DCs, similar to the mice lacking membrane LT alpha/beta...
  56. ncbi Lymphoid neo-organogenesis: lymphotoxin's role in inflammation and development
    N H Ruddle
    Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Immunol Res 19:119-25. 1999
    ....
  57. pmc Nonlymphocyte-derived tumor necrosis factor is required for induction of colitis in recombination activating gene (RAG)2(-/-) mice upon transfer of CD4(+)CD45RB(hi) T cells
    N Corazza
    Institute of Pathology, Division of Immunopathology, University of Bern, CH 3010 Bern, Switzerland
    J Exp Med 190:1479-92. 1999
    ..These results demonstrate the importance of TNF production by non-T cells of the colonic mucosa in the pathogenesis of colitis and provide direct evidence for a nonredundant role of TNF-alpha in this mouse model of colitis...
  58. ncbi TNF and lymphotoxin beta cooperate in the maintenance of secondary lymphoid tissue microarchitecture but not in the development of lymph nodes
    D V Kuprash
    Laboratory of Molecular Immunology, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow State University, Russia
    J Immunol 163:6575-80. 1999
    ..Most lymphotoxin alpha (ltalpha)- and all lymphotoxin beta receptor (ltbetar)-deficient mice are completely devoid of lymph nodes (..
  59. ncbi BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis
    S A Luther
    Department of Microbiology and Immunology, University of California, San Francisco 94143, USA
    Immunity 12:471-81. 2000
    ..These findings establish that BLC is sufficient to activate a pathway of events leading to formation of organized lymphoid tissue...
  60. ncbi A chemokine-driven positive feedback loop organizes lymphoid follicles
    K M Ansel
    Department of Microbiology and Immunology, University of California San Francisco, 94143, USA
    Nature 406:309-14. 2000
    ..In germinal centres the feedback loop is overridden, with B-cell lymphotoxin alpha1beta2 expression being induced by a mechanism independent of BLC...
  61. ncbi Antigen persistence is required for somatic mutation and affinity maturation of immunoglobulin
    Y Wang
    Department of Pathology, The University of Chicago, Chicago 60637, USA
    Eur J Immunol 30:2226-34. 2000
    ..Thus, these data support a model in which prolonged availability of antigen is required for somatic mutation and affinity maturation, and FDC or adjuvants facilitate such processes by slowly releasing antigens...
  62. ncbi Signal via lymphotoxin-beta R on bone marrow stromal cells is required for an early checkpoint of NK cell development
    Q Wu
    Department of Pathology and Neurology, University of Chicago, Chicago, IL 60637, USA
    J Immunol 166:1684-9. 2001
    ..Lymphotoxin-alpha (LTalpha)(-/-) and LTbetaR(-/-) mice show a severe systemic reduction of NK cells, which provides an excellent model to ..
  63. pmc Secreted lymphotoxin-alpha is essential for the control of an intracellular bacterial infection
    D R Roach
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown NSW 2042, Australia
    J Exp Med 193:239-46. 2001
    ..To overcome the lack of peripheral lymph nodes in LTalpha-/- and LTbeta-/- mice, bone marrow chimeric mice were constructed...
  64. pmc Essential role of lymph nodes in contact hypersensitivity revealed in lymphotoxin-alpha-deficient mice
    P D Rennert
    Department of Immunology and Inflammation, Biogen, Incorporated, 14 Cambridge Center, Cambridge, MA 02142, USA
    J Exp Med 193:1227-38. 2001
    ....
  65. pmc Generation of experimental allergic airways inflammation in the absence of draining lymph nodes
    B U Gajewska
    Department of Pathology and Molecular Medicine, and Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada
    J Clin Invest 108:577-83. 2001
    ..We executed this protocol in wild-type (WT) and lymphotoxin-alpha-deficient mice (LTalpha-KO) mice, which are devoid of lymph nodes (LNs) and possess rudimentary spleen structures...
  66. pmc Splenic T zone development is B cell dependent
    V N Ngo
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA
    J Exp Med 194:1649-60. 2001
    ..Introduction of a B cell specific LTalpha transgene on to the LTalpha-deficient background restored splenic CCL21 and gp38 expression, DC numbers, and T ..
  67. ncbi Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine
    Hiromasa Hamada
    Department of Microbiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Immunol 168:57-64. 2002
    ..Neither ILF nor PP are detectable in lymphotoxin alpha(-/-) and aly/aly mice that retain well-developed cryptopatches (CP) and thymus-independent subsets of ..
  68. ncbi Cutting edge: organogenesis of nasal-associated lymphoid tissue (NALT) occurs independently of lymphotoxin-alpha (LT alpha) and retinoic acid receptor-related orphan receptor-gamma, but the organization of NALT is LT alpha dependent
    Allen Harmsen
    Department of Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
    J Immunol 168:986-90. 2002
    ..we found that NALT was formed in the absence of CD4+CD3- cells, which are thought to be the embryonic source of LTalpha. However, we also found that NALT of LTalpha-/- animals was disorganized and lymphopenic, suggesting that the ..
  69. ncbi Signaling via LTbetaR on the lamina propria stromal cells of the gut is required for IgA production
    Hyung Sik Kang
    Department of Pathology and Committee on Immunology, The University of Chicago, 5841 S Maryland, Chicago, IL 60637, USA
    Nat Immunol 3:576-82. 2002
    ..Consistently, lymphoid tissue chemokines and adhesion molecules were reduced within the LP of LTalpha(-/-) and LTbetaR(-/-) mice...
  70. ncbi Membrane lymphotoxin contributes to anti-leishmanial immunity by controlling structural integrity of lymphoid organs
    Patricia Wilhelm
    Institut fur Klinische Mikrobiologie, Immunologie und Hygiene der Universität Erlangen Nürnberg, Erlangen, Germany
    Eur J Immunol 32:1993-2003. 2002
    ..LTbeta-/-) and compared it to a unique series of LTalpha-, TNF- and TNF/LTalpha-gene-targeted mice on an identical genetic background (B6.LTalpha-/-, B6...
  71. pmc Lymphotoxin is required for maintaining physiological levels of serum IgE that minimizes Th1-mediated airway inflammation
    Hyung Sik Kang
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    J Exp Med 198:1643-52. 2003
    ..Lymphotoxin-deficient alpha (LTalpha-/-) mice exhibit increased airway inflammation, paradoxically accompanied by diminished levels of IgE and reduced ..
  72. pmc Intestinal villous M cells: an antigen entry site in the mucosal epithelium
    Myoung Ho Jang
    Department of Mucosal Immunology, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 101:6110-5. 2004
    ..lymphoid tissue (GALT)]-null mice, such as in utero lymphotoxin beta receptor (LTbetaR)-Ig-treated, lymphotoxin alpha (LTalpha)(-/-), tumor necrosis factor/LTalpha(-/-), and inhibition of differentiation 2 (Id2)(-/-) mice...
  73. ncbi Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells
    Gerard Eberl
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Science 305:248-51. 2004
    ..Our results suggest that intestinal RORgammat+ cells are local organizers of mucosal lymphoid tissue...
  74. ncbi Intestinal cryptopatch formation in mice requires lymphotoxin alpha and the lymphotoxin beta receptor
    Rebekah T Taylor
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 173:7183-9. 2004
    ..In this study, we assessed the contributions of LTalpha and LTbetaR to the development of cryptopatches (CP), aggregates of T cell precursors in the mouse small ..
  75. pmc Lymphotoxin plays a crucial role in the development and function of nasal-associated lymphoid tissue through regulation of chemokines and peripheral node addressin
    Xiaoyan Ying
    Yale University School of Medicine, Department of Epidemiology and Public Health, 60 College St, P O Box 208034, New Haven, CT 06520 8034, USA
    Am J Pathol 166:135-46. 2005
    ....
  76. ncbi Intrinsic lymphotoxin-beta receptor requirement for homeostasis of lymphoid tissue dendritic cells
    Kenji Kabashima
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, California 94143, USA
    Immunity 22:439-50. 2005
    ..B cells are a key source of LT alpha 1 beta 2 for splenic DC homeostasis, and transgenic overexpression of LT alpha 1 beta 2 on B cells leads to ..
  77. pmc Independent protective effects for tumor necrosis factor and lymphotoxin alpha in the host response to Listeria monocytogenes infection
    D R Roach
    Centenary Institute of Cancer Medicine and Cell Biology, Locked Bag No 6, Newtown, NSW 2042, Australia
    Infect Immun 73:4787-92. 2005
    ..in resistance to Listeria monocytogenes infection is well established, the roles of the related cytokines lymphotoxin alpha (LTalpha) and lymphotoxin beta (LTbeta) are unknown...
  78. ncbi Function of CD4+CD3- cells in relation to B- and T-zone stroma in spleen
    Mi Yeon Kim
    Medical Research Council, Centre for Immune Regulation, Institute for Biomedical Research, Birmingham Medical School, UK
    Blood 109:1602-10. 2007
    ..CD4+CD3- cells express high levels of LTalpha, LTbeta, and tumor necrosis factor (TNF) alpha, which are the ligands for the LTbeta receptor and TNFR1 expressed ..
  79. ncbi Naive recirculating B cells mature simultaneously in the spleen and bone marrow
    Annaiah Cariappa
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Blood 109:2339-45. 2007
    ..B-cell maturation in the bone marrow was obtained from analyses of transitional B cells in splenectomized lymphotoxin alpha-deficient mice that lack all secondary lymphoid organs...
  80. pmc Murine cerebral malaria development is independent of toll-like receptor signaling
    Dieudonnée Togbe
    Molecular Immunology and Embryology, Centre National de la Recherche Scientifique, and University of Orleans, Transgenose Institute, Orleans, France
    Am J Pathol 170:1640-8. 2007
    ..In contrast to lymphotoxin alpha-deficient mice, which are resistant to CM, all TLR-deficient mice were as sensitive to fatal CM development ..
  81. pmc RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla
    Simona W Rossi
    Medical Research Council Centre for Immune Regulation, Institute for Biomedical Research, University of Birmingham, B15 2TT Birmingham, UK
    J Exp Med 204:1267-72. 2007
    ..Collectively, our data reveal cellular and molecular mechanisms leading to the generation of Aire(+) mTECs and highlight a previously unrecognized role for CD4(+)3(-)RANKL(+) inducer cells in intrathymic self-tolerance...
  82. ncbi Lymphotoxin a-dependent and -independent signals regulate stromal organizer cell homeostasis during lymph node organogenesis
    Andrea White
    Division of Immunity and Infection, Instiute for BioMedical Research Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, United Kingdom
    Blood 110:1950-9. 2007
    ..In addition, analysis of the lymph node anlagen in normal and lymphotoxin a (LTa)-deficient embryos shows that LTa-mediated signaling is required to sustain proliferation and survival of stromal ..
  83. ncbi The role of lymphoid tissue inducer cells in splenic white pulp development
    David R Withers
    MRC Centre for Immune Regulation, Institute for Biomedical Research, Birmingham Medical School, Birmingham, UK
    Eur J Immunol 37:3240-5. 2007
    ..Transfer experiments reconstituting RAG(-/-) mice with either WT or LTalpha(-/-) splenocytes demonstrated that lymphocyte expression of LT was not essential for the organisation of a ..
  84. doi Separation of splenic red and white pulp occurs before birth in a LTalphabeta-independent manner
    Mark F R Vondenhoff
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    J Leukoc Biol 84:152-61. 2008
    ..The postnatal development of the splenic white pulp, involving the influx of T cells, depends on LTalpha1beta2 expressed by B cells...
  85. pmc Overexpression of lymphotoxin in T cells induces fulminant thymic involution
    Mathias Heikenwalder
    Institute of Neuropathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Am J Pathol 172:1555-70. 2008
    ..Multiple lines of transgenic Ltalphabeta and Ltalpha mice show such a phenotype, which was not observed on overexpression of LTbeta alone...
  86. pmc Omental milky spots develop in the absence of lymphoid tissue-inducer cells and support B and T cell responses to peritoneal antigens
    Javier Rangel-Moreno
    Division of Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY 14642, USA
    Immunity 30:731-43. 2009
    ..These results indicate that the milky spots of the omentum function as unique secondary lymphoid organs that promote immunity to peritoneal antigens...
  87. doi Targeted depletion of lymphotoxin-alpha-expressing TH1 and TH17 cells inhibits autoimmune disease
    Eugene Y Chiang
    Department of Immunology, South San Francisco, California, USA
    Nat Med 15:766-73. 2009
    ..These data indicate that depleting LT-alpha-expressing lymphocytes with LT-alpha-specific mAb may be beneficial in the treatment of autoimmune disease...
  88. pmc Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation
    Serge A van de Pavert
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Nat Immunol 10:1193-9. 2009
    ..Therefore, our data show that the initiation of lymph node development is controlled by RA-mediated expression of CXCL13 and suggest that RA may be provided by adjacent neurons...
  89. pmc Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity
    Takahiro Nagatake
    Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    J Exp Med 206:2351-64. 2009
    ..Thus, TALT shares immunological features with MALT but has a distinct tissue genesis mechanism and plays a key role in ocular immunity...
  90. ncbi Characterization of several new MHC congenic strains
    A C Walsh
    Department of Microbiology and Immunology, Albany Medical College, NY
    Immunogenetics 33:290-3. 1991
  91. ncbi Mouse lymphotoxin and tumor necrosis factor: structural analysis of the cloned genes, physical linkage, and chromosomal position
    S M Gardner
    J Immunol 139:476-83. 1987
    ..Comparison of the 5' flanking sequence of LT to a number of genes that are specifically expressed in activated T cells reveals a number of conserved sequences that may play a role in control of these genes...
  92. ncbi Induction of tumor necrosis factor-alpha and -beta and interferon-gamma mRNA by interleukin 2 in murine lymphocytic cell lines
    D Weil
    Laboratoire d Oncologie Moleculaire, CNRS UA 1158, Institut Gustave Roussy, Villejuif, France
    Oncogene Res 3:409-14. 1988
    ..As activated T lymphocytes express receptors to both TNF and IFN-gamma, our observation raises the possibility that these lymphokines are involved in an autocrine regulation of cytotoxic lymphocytes proliferation...
  93. ncbi Recombination in the class III region of the mouse major histocompatibility complex
    M Yoshino
    Mammalian Genetics Laboratory, National Institute of Genetics, Mishima, Japan
    Immunogenetics 40:280-6. 1994
    ..The results gave the gene order of Eb-61.1-Int3-Tnx-Cyp21/C4-Bf-Hsp68c-D17Mit13+ ++-Tnfa/Tnfb-D. The crossover sites in 40 of the 79 recombinants were confined within the Eb/Int3:Tnx/Cyp21 interval...
  94. ncbi An evolutionary and functional approach to the TNF receptor/ligand family
    B Beutler
    Howard Hughes Medical Institute, Dallas, Texas 75235 9050
    Ann N Y Acad Sci 730:118-33. 1994
  95. pmc Distribution and kinetics of superantigen-induced cytokine gene expression in mouse spleen
    M Bette
    First Department of Medicine, University of Mainz, Germany
    J Exp Med 178:1531-9. 1993
    ..These data show that nonphagocytic cells are the essential superantigen-presenting cells in vivo and indicate that at least part of the pathogenetic TNF-alpha is T cell derived...
  96. ncbi Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor
    R G Goodwin
    Immunex Research and Development Corporation, Seattle, Washington 98101
    Cell 73:447-56. 1993
    ..Biological characterization indicates that the cloned ligand induces the proliferation of costimulated T cells and enhances the generation of cytolytic T cells...
  97. ncbi High-resolution comparative mapping of mouse chromosome 17
    H Himmelbauer
    Department of Molecular Biology, Princeton University, New Jersey 08544 1014
    Genomics 17:110-20. 1993
    ..We present the localization of four new DNA markers and determined map positions for 10 other loci, which previously had been assigned to intervals of the t complex only through the study of partial t haplotype chromosomes...
  98. ncbi Expression and function of the early activation antigen CD69 in murine macrophages
    R Marzio
    Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland
    J Leukoc Biol 62:349-55. 1997
    ..These results suggest that CD69 is an activation antigen for murine macrophages and may serve as a signaling receptor for an as yet uncharacterized ligand...
  99. ncbi Control of nitric oxide production by endogenous TNF-alpha in mouse retinal pigmented epithelial and Muller glial cells
    O Goureau
    Developpement, Vieillissement et Pathologie de la Retine, U450 INSERM, Association C Bernard, Paris, France
    Biochem Biophys Res Commun 240:132-5. 1997
    ..TNF alpha), we have investigated in vitro the production of NO in retinal cells from mice deficient in Lymphotoxin alpha (LT alpha)/TNF alpha...
  100. ncbi Increased susceptibility of TNF-alpha lymphotoxin-alpha double knockout mice to systemic candidiasis through impaired recruitment of neutrophils and phagocytosis of Candida albicans
    M G Netea
    Department of Medicine, University Hospital Nijmegen, The Netherlands
    J Immunol 163:1498-505. 1999
    ..albicans...
  101. pmc Lymphotoxin-alpha-deficient mice can clear a productive infection with murine gammaherpesvirus 68 but fail to develop splenomegaly or lymphocytosis
    B J Lee
    La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Virol 74:2786-92. 2000
    ..Lymphotoxin- alpha-deficient (LTalpha(-/-)) mice have no lymph nodes and have disrupted splenic architecture...

Research Grants16

  1. VIRUSES AND AUTOIMMUNE DISEASE
    Michael Oldstone; Fiscal Year: 2001
    ..The second order of business is to determine the role of "self" (islet-cell) antigens other than the initial triggering viral antigen in the pathogenetic process leading to and determine their role in IDDM. ..
  2. STUDIES OF A NEW MYELIN GENE THAT CAUSES CNS DISEASE
    Michael Oldstone; Fiscal Year: 2001
    ..Their studies in rodents combined with those of their collaborator, Dr. Martin, should begin to characterize the role played by MONP in neurologic disease. ..
  3. Pathogenesis Studies in Scrapie (TSE Diseases)
    Michael Oldstone; Fiscal Year: 2003
    ..This model should be useful to study pathophysiology of CWD as well as probing CWD strain differences. ..
  4. ORPHAN NUCLEAR RORgammat IN THYMOCYTE DIFFERENTIATION
    You Wen He; Fiscal Year: 2006
    ..In addition, results from this application will also provide insights for the role of ROR-gamma-t in tumorigenesis. ..
  5. MEASLES VIRUS STUDIES IN A TRANSGENIC MODEL
    Michael Oldstone; Fiscal Year: 2007
    ..abstract_text> ..
  6. Extracellular Matrix Protein in Innate Immunity
    You Wen He; Fiscal Year: 2007
    ..Results from this proposal will provide novel insights on the mechanisms of the innate immune response and may have implication for clinical treatment of septic shock and other microbe caused diseases. [unreadable] [unreadable]..
  7. Pattern Recognition Molecule Mindin As Adjuvant
    You Wen He; Fiscal Year: 2007
    ..Third, Mindin fused DNA plasmids will be examined for their efficacy in protecting influenza virus infection. [unreadable] [unreadable]..
  8. Therapeutics to Prevent/Treat Lassa Fever Virus
    Michael B Oldstone; Fiscal Year: 2010
    ..We anticipate making a significant contribution to drug development to treat these BSL-4 agents. ..
  9. TERTIARY LYMPHOID ORGANS IN TYPE I DIABETES MELLITUS
    NANCY RUDDLE; Fiscal Year: 2003
    ..Mice transgenic for lymphotoxin (LTalpha; TNFbeta) under the control of the insulin promoter (RIPLT mice) express the transgene in the pancreas and kidney ..
  10. The role of TNF receptor family in intestinal GVHD
    GERI BROWN; Fiscal Year: 2004
    ..abstract_text> ..
  11. Viruses and Diabetes
    Michael Oldstone; Fiscal Year: 2005
    ....
  12. LYMPHOTOXIN: REGULATION AND BIOLOGICAL SIGNIFICANCE
    NANCY RUDDLE; Fiscal Year: 2006
    ..Differences between LTalpha and LTBeta with regard to the NALT development and function will be studied as will the temporal and kinetic ..
  13. Aging Disease--Prion/Transgenic/Immunologic Studies
    Michael Oldstone; Fiscal Year: 2008
    ..Lastly, Jose Criado will continue his electrophysiology and behavioral studies on the normal function of PrP and on its aberrations during TSE disease. ..
  14. Neural-Immune Interacations: Pathology and Molecular Mechanisms of Repair
    NANCY RUDDLE; Fiscal Year: 2008
    ..The ultimate goal is to provide prevention and treatment of diseases that involve interactions between these two systems. [unreadable] [unreadable] [unreadable] [unreadable]..
  15. Arenavirus Receptor-Structure/Function Studies
    Michael B Oldstone; Fiscal Year: 2010
    ..These findings have relevance for biodefense of several viruses including LFV. ..
  16. LYMPHOTOXIN AND LYMPHOID NEOGENESIS
    Nancy H Ruddle; Fiscal Year: 2010
    ..Directed over expression of lymphotoxin (LT) (either LTa or LTab) results in ectopic lymphoid aggregates with the characteristics of lymphoid organs...