Genomes and Genes
Gene Symbol: Lrp2
Description: low density lipoprotein receptor-related protein 2
Alias: AI315343, AW536255, D230004K18Rik, Gp330, Megalin, b2b1625.2Clo, low-density lipoprotein receptor-related protein 2, LRP-2, glycoprotein 330
- APC-dependent suppression of colon carcinogenesis by PPARgammaGeoffrey D Girnun
Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, One Jimmy Fund Way, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 99:13771-6. 2002..This finding suggests a potentially important use for PPARgamma ligands as chemopreventative agents in colon cancer...
- Expression and role of cubilin in the internalization of nutrients during the peri-implantation development of the rodent embryoEmeline Assemat
INSERM, UMR 538, Faculte de Medecine Saint Antoine, Paris, France
Biol Reprod 72:1079-86. 2005..to the maternal environment or to the amniotic and neural tube cavities, and had a very similar distribution to megalin, a member of the LDLR gene family and a coreceptor for cubilin in adult tissues...
- Low-density lipoprotein receptor-related protein (LRP)-2/megalin is transiently expressed in a subpopulation of neural progenitors in the embryonic mouse spinal cordGrzegorz Wicher
Department of Neuroscience, Biomedical Center, Uppsala University, Sweden
J Comp Neurol 492:123-31. 2005The lipoprotein receptor LRP2/megalin is expressed by absorptive epithelia and involved in receptor-mediated endocytosis of a wide range of ligands...
- Transthyretin internalization by sensory neurons is megalin mediated and necessary for its neuritogenic activityCarolina E Fleming
Instituto de Biologia Molecular e Celular IBMC, Nerve Regeneration Group and Molecular Neurobiology Group, 4150 180 Porto, Portugal
J Neurosci 29:3220-32. 2009..Moreover, we show that in vitro, in dorsal root ganglia neurons, clathrin-dependent megalin-mediated TTR internalization is needed for TTR neuritogenic activity...
- Megalin/LRP2 expression is induced by peroxisome proliferator-activated receptor -alpha and -gamma: implications for PPARs' roles in renal functionFelipe Cabezas
Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago, Chile
PLoS ONE 6:e16794. 2011b>Megalin is a large endocytic receptor with relevant functions during development and adult life...
- Syntaxin 3 and Munc-18-2 in epithelial cells during kidney developmentS Lehtonen
Haartman Institute and Department of Pathology, University of Helsinki, Finland
Kidney Int 56:815-26. 1999..We have analyzed the expression patterns of vesicle-docking proteins of the syntaxin family in mouse kidney, focusing on syntaxin 3 and its interaction partner, the Sec1-related Munc-18-2...
- Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesisDong Hua Yang
Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
Dev Biol 251:27-44. 2002..We suggest that Dab2 functions in a signal pathway to regulate endodermal cell organization using endocytosis of ligands from the blastocoel cavity as a positioning cue...
- Megalin is essential for renal proximal tubule reabsorption and accumulation of transcobalamin-B(12)Henrik Birn
Department of Cell Biology, Institute of Anatomy, University of Aarhus, DK 8000 Aarhus C, Germany
Am J Physiol Renal Physiol 282:F408-16. 2002b>Megalin has previously been shown to bind and mediate endocytosis of transcobalamin (TC)-B(12)...
- The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomesShigeyki Nada
Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
EMBO J 28:477-89. 2009..These results indicate that the lipid raft adaptor p18 is essential for anchoring the MEK-ERK pathway to late endosomes, and shed new light on a role of endosomal MEK-ERK pathway in controlling endosome dynamics...
- Megalin contributes to the early injury of proximal tubule cells during nonselective proteinuriaYaeko Motoyoshi
Department of Bioethics, Tokai University School of Medicine, Isehara City, Kanagawa, Japan
Kidney Int 74:1262-9. 2008b>Megalin, a member of the LDL receptor family, is expressed on the apical membrane of proximal tubules and serves as an endocytic scavenger of filtered proteins and hence might contribute to the tubule injury as a consequence of ..
- Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteinsS M Hammad
Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425 2204, USA
J Biol Chem 275:12003-8. 2000..Since cubilin has been reported to bind the endocytic receptor megalin, we explored the possibility that megalin acts in conjunction with cubilin to mediate HDL endocytosis...
- Cubilin is essential for albumin reabsorption in the renal proximal tubuleSabine Amsellem
INSERM UMR S968, Institut de la Vision, 17 rue Moreau, 75012 Paris, France
J Am Soc Nephrol 21:1859-67. 2010..This process involves two interacting receptors, megalin and cubilin, which form a complex with amnionless...
- MESD is essential for apical localization of megalin/LRP2 in the visceral endodermJanet K Lighthouse
Dev Dyn 240:577-88. 2011..Moreover, we demonstrated that MESD was essential for the apical localization of the related LRP2 (Megalin/MEG) in the visceral endoderm, resulting in impaired endocytic function...
- Targeted disruption of cubilin reveals essential developmental roles in the structure and function of endoderm and in somite formationBrian T Smith
Department of Cell Biology and Anatomy Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
BMC Dev Biol 6:30. 2006Cubilin is a peripheral membrane protein that interacts with the integral membrane proteins megalin and amnionless to mediate ligand endocytosis by absorptive epithelia such as the extraembryonic visceral endoderm (VE).
- Megalin knockout mice as an animal model of low molecular weight proteinuriaJ R Leheste
Max Delbrueck Center for Molecular Medicine, Berlin, Germany
Am J Pathol 155:1361-70. 1999b>Megalin is an endocytic receptor expressed on the luminal surface of the renal proximal tubules. The receptor is believed to play an important role in the tubular uptake of macromolecules filtered through the glomerulus...
- Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defectJörg R Leheste
Max Delbrueck Center for Molecular Medicine, Berlin, Germany
FASEB J 17:247-9. 2003b>Megalin is an endocytic receptor highly expressed in the proximal tubules of the kidney...
- An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3A Nykjaer
Max Delbrueck Center for Molecular Medicine, Berlin, Germany
Cell 96:507-15. 1999..protein, is filtered through the glomerulus and reabsorbed in the proximal tubules by the endocytic receptor megalin. Endocytosis is required to preserve 25-(OH) vitamin D3 and to deliver to the cells the precursor for generation ..
- Megalin binds and internalizes angiotensin-(1-7)Romer Gonzalez-Villalobos
Dept of Medicine Section of Nephrology SL 45, Tulane Univ Health Sciences Ctr, 1430 Tulane Ave, New Orleans, LA 70112, USA
Am J Physiol Renal Physiol 290:F1270-5. 2006b>Megalin is a multiligand receptor heavily involved in protein endocytosis. We recently demonstrated that megalin binds and mediates internalization of ANG II...
- Choroid plexus megalin is involved in neuroprotection by serum insulin-like growth factor IEva Carro
Laboratory of Neuroendocrinology, Cajal Institute, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
J Neurosci 25:10884-93. 2005..We found that physical exercise increases the levels of the choroid plexus endocytic receptor megalin/low-density lipoprotein receptor-related protein-2 (LRP2), a multicargo transporter known to participate in brain ..
- Endocytosis of megalin by visceral endoderm cells requires the Dab2 adaptor proteinMeghan E Maurer
Division of Basic Sciences and Molecular and Cellular Biology Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
J Cell Sci 118:5345-55. 2005..The lipoprotein receptor megalin is expressed in the visceral endoderm (VE), a polarized epithelium that supplies maternal nutrients to the early ..
- Mutually dependent localization of megalin and Dab2 in the renal proximal tubuleJ Nagai
Cell Biology, Institute of Anatomy, Univ of Aarhus, University Park, Bldg 234, DK 8000 Aarhus C, Denmark
Am J Physiol Renal Physiol 289:F569-76. 2005..Dab2) is a cytoplasmic adaptor protein that binds to the cytoplasmic tail of the multiligand endocytic receptor megalin, abundantly expressed in renal proximal tubules...
- Defective forebrain development in mice lacking gp330/megalinT E Willnow
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235, USA
Proc Natl Acad Sci U S A 93:8460-4. 1996gp330/megalin, a member of the low density lipoprotein (LDL) receptor gene family, is expressed on the apical surfaces of epithelial tissues, including the neuroepithelium, where it mediates the endocytic uptake of diverse macromolecules,..
- LRP2/megalin is required for patterning of the ventral telencephalonRobert Spoelgen
Max Delbrueck Center for Molecular Medicine, Berlin, 13092, Germany
Development 132:405-14. 2005b>Megalin is a low-density lipoprotein receptor-related protein (LRP2) expressed in the neuroepithelium and the yolk sac of the early embryo...
- Differential distribution of cubilin and megalin expression in the mouse embryoChristopher J Drake
Medical University of South Carolina, Department of Cell Biology, Charleston, South Carolina, USA
Anat Rec A Discov Mol Cell Evol Biol 277:163-70. 2004Cubilin and megalin are cell surface proteins that work cooperatively in many absorptive epithelia to mediate endocytosis of lipoproteins, vitamin carriers, and other proteins...
- Mouse amnionless, which is required for primitive streak assembly, mediates cell-surface localization and endocytic function of cubilin on visceral endoderm and kidney proximal tubulesSharon Strope
Molecular Biology Graduate Program, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA
Development 131:4787-95. 2004....
- Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosisKanako Saito
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
Proc Natl Acad Sci U S A 106:8350-5. 2009..Moreover, our data reveal a hitherto unknown compensatory process by which the neural stem and progenitor cells of the developing mammalian brain evade the detrimental consequences of impaired endogenous cholesterol biosynthesis...
- Mouse model of proximal tubule endocytic dysfunctionKathrin Weyer
Department of Biomedicine, University of Aarhus, Aarhus, Denmark
Nephrol Dial Transplant 26:3446-51. 2011Several studies have indicated the central role of the megalin/cubilin multiligand endocytic receptor complex in protein reabsorption in the kidney proximal tubule...
- Mutation mapping and identification by whole-genome sequencingIgnaty Leshchiner
Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Genome Res 22:1541-8. 2012..Our novel methodology and online tools will make next-generation sequencing an easily applicable resource for mutation mapping in all model systems...
- The transcobalamin receptor knockout mouse: a model for vitamin B12 deficiency in the central nervous systemShao Chiang Lai
School of Graduate Studies, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
FASEB J 27:2468-75. 2013..01). The CNS pathology of Cbl deficiency seen in humans may not manifest in this mouse model; however, it does provide a model with which to evaluate metabolic pathways and genes affected...
- Maternal-fetal transfer of selenium in the mouseRaymond F Burk
Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
FASEB J 27:3249-56. 2013..Mice with genetic alterations of Sepp1, the Sepp1 receptors apolipoprotein E receptor-2 (apoER2) and megalin, and Gpx3 were used to investigate maternal-fetal selenium transfer...
- Clusterin and LRP2 are critical components of the hypothalamic feeding regulatory pathwaySo Young Gil
Asan Institute for Life Science, University of Ulsan College of Medicine, Seoul 138 736, Korea
Nat Commun 4:1862. 2013..Our study identifies the hypothalamic clusterin-low-density lipoprotein receptor-related protein-2 axis as a novel anorexigenic signalling pathway that is tightly coupled with long-form leptin receptor-mediated signalling...
- Renal uptake of the antiapoptotic protein survivin is mediated by megalin at the apical membrane of the proximal tubuleTilman Jobst-Schwan
Dept of Nephrology and Hypertension, Friedrich Alexander Univ Erlangen Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany
Am J Physiol Renal Physiol 305:F734-44. 2013..Several proteins in primary urine are internalized by megalin, an endocytosis receptor, which is in principle found in the same localization as survivin...
- ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expressionMehul Shah
Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
J Cell Biol 202:113-27. 2013..Here we show that autosomal recessive hypercholesterolemia (ARH) is required for trafficking of megalin, a member of the LDL receptor family, from EE to the ERC by coupling it to dynein; in the absence of ARH, megalin ..
- Arf4 is required for Mammalian development but dispensable for ciliary assemblyJohn A Follit
Program in Molecular Medicine, University of Massachusetts Medical School, Biotech II, Worcester, Massachusetts, United States of America
PLoS Genet 10:e1004170. 2014..This work suggests that while Arf4 is not required for ciliary assembly, it is important for the efficient transport of fibrocystin to cilia, and also plays critical roles in non-ciliary processes. ..
- LRP2 mediates folate uptake in the developing neural tubeEsther Kur
Max Delbrück Center for Molecular Medicine MDC, Robert Rossle Strasse 10, 13125 Berlin, Germany
J Cell Sci 127:2261-8. 2014The low-density lipoprotein (LDL) receptor-related protein 2 (LRP2) is a multifunctional cell-surface receptor expressed in the embryonic neuroepithelium...
- Mechanisms of AT1a receptor-mediated uptake of angiotensin II by proximal tubule cells: a novel role of the multiligand endocytic receptor megalinXiao C Li
Laboratory of Receptor and Signal Transduction, Department of Pharmacology and Toxicology, Cardiovascular and Renal Research Center, Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi
Am J Physiol Renal Physiol 307:F222-33. 2014The present study tested the hypothesis that the multiligand endocytic receptor megalin is partially involved in the uptake of ANG II and downstream signaling responses in mouse proximal tubule cells (mPCT) by interacting with AT1a ..
- Megalin-deficiency causes high myopia, retinal pigment epithelium-macromelanosomes and abnormal development of the ciliary body in miceTina Storm
Department of Biomedicine, Faculty of Health Sciences, Aarhus University, Wilhelm Meyers Allé 3, DK 8000, Aarhus, Denmark
Cell Tissue Res 358:99-107. 2014In man, mutations of the megalin-encoding gene causes the rare Donnai-Barrow/Facio-Oculo-Acoustico-Renal Syndrome, which is partially characterized by high-grade myopia...
- Dynamic changes in leptin distribution in the progression from ovum to blastocyst of the pre-implantation mouse embryoLaura C Schulz
Department of Obstetrics, Gynecology and Women s Health, N625A Health Sciences Center, 1 Hospital Drive, Columbia, Missouri 65212, USA
Reproduction 141:767-77. 2011..Throughout development, leptin co-localized with LRP2, a multi-ligand transport protein, and its patterning resembled that noted for the maternal-effect proteins OOEP, ..
- Internalization of odorant-binding proteins into the mouse olfactory epitheliumJörg Strotmann
Institute of Physiology, University of Hohenheim, Stuttgart, Germany
Histochem Cell Biol 136:357-69. 2011..that could mediate such an uptake process led to the identification of the low density lipoprotein receptor Lrp2/Megalin. In the olfactory epithelium, megalin was found to be specifically expressed in sustentacular cells and the ..
- A forward genetic screen in mice identifies mutants with abnormal cortical patterningSeungshin Ha
Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA Center for Developmental Biology and Regenerative Medicine, Seattle Children s Research Institute, University of Washington School of Medicine, Seattle, WA 98101, USA
Cereb Cortex 25:167-79. 2015..axon development were also identified, one of which was found by whole-genome resequencing to carry a mutation in Lrp2. These findings demonstrated that the application of ENU mutagenesis to mice carrying transgenic reporters marking ..
- The soluble intracellular domain of megalin does not affect renal proximal tubular function in vivoAnnabel Christ
Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, Berlin, Germany
Kidney Int 78:473-7. 2010b>Megalin-mediated endocytic uptake constitutes the main pathway for clearance of plasma proteins from the glomerular filtrate in proximal tubules...
- Renal phenotypic investigations of megalin-deficient patients: novel insights into tubular proteinuria and albumin filtrationTina Storm
Department of Biomedicine, Universityof Aarhus, Aarhus, Denmark
Nephrol Dial Transplant 28:585-91. 2013..Studies of megalin-deficient mice suggest that the large multi-ligand endocytic receptor megalin plays an essential role in this ..
- Megalin mediates the influence of sonic hedgehog on oligodendrocyte precursor cell migration and proliferation during developmentMaría Cristina Ortega
Grupo de Neurobiología del Desarrollo GNDe, Unidad de Neurologia Experimental, Hospital Nacional de Paraplejicos, Finca La Peraleda s n, Toledo, Spain
Glia 60:851-66. 2012..However, the multiligand receptor megalin (or LRP-2) is also involved in Shh-induced OPC proliferation and migration, and thus, we have evaluated the ..
- Expression of the megalin C-terminal fragment by macrophages during liver fibrogenesis in miceUrsula Pieper-Fürst
Department of Internal Medicine I, University Hospital Bonn, Germany
Biochim Biophys Acta 1812:1640-8. 2011The low-density-lipoprotein receptor megalin (LRP2, gp330) is strongly expressed in the kidney, where it is responsible for the resorption of metabolites from primary urine...
- Receptor-associated protein is important for normal processing of megalin in kidney proximal tubulesH Birn
Department of Cell Biology, Institute of Anatomy, University of Aarhus, Denmark
J Am Soc Nephrol 11:191-202. 2000..RAP also binds to the related 600-kD multiligand endocytic receptor megalin expressed in many absorptive epithelia including renal proximal tubule...
- A novel renal carbonic anhydrase type III plays a role in proximal tubule dysfunctionP Gailly
Division of Cell Physiology, Christian de Duve Institute of Cellular Pathology, Universite Catholique de Louvain, Brussels, Belgium
Kidney Int 74:52-61. 2008..carbonic anhydrase type III (CAIII) upregulation was confirmed in other mice lacking the multiligand receptor megalin and in a patient with Dent's disease due to an inactivating CLCN5 mutation...
- Megalin interacts with APP and the intracellular adapter protein FE65 in neuronsXimena Alvira-Botero
Laboratory of Neuroscience, Research Center, Hospital 12 de Octubre, 28041 Madrid, Spain
Mol Cell Neurosci 45:306-15. 2010Increasing evidence has implicated megalin, a low-density lipoprotein receptor-related protein, in the pathogenesis of Alzheimer's disease (AD)...
- LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic nicheChandresh R Gajera
Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, D 13125 Berlin, Germany
J Cell Sci 123:1922-30. 2010..We demonstrate that LRP2, a clearance receptor for BMP4 is specifically expressed in ependymal cells of the lateral ventricles in the adult ..
- Altered expression of metallothionein-I and -II and their receptor megalin in inherited photoreceptor degenerationKirsten A Wunderlich
Department of Ophthalmology, Clinical Sciences Lund, Lund University, Lund, Sweden
Invest Ophthalmol Vis Sci 51:4809-20. 2010To examine in rodent models of retinitis pigmentosa (RP) the expression of the neuroprotectants metallothionein-I and -II and of megalin, an endocytic receptor that mediates their transport into neurons.
- Cubilin is an albumin binding protein important for renal tubular albumin reabsorptionH Birn
Department of Cell Biology, University of Aarhus, Aarhus, Denmark
J Clin Invest 105:1353-61. 2000..In addition, we find that mice lacking the endocytic receptor megalin show altered urinary excretion, and reduced tubular reabsorption, of albumin...
- Expression patterns of the aquaporin gene family during renal development: influence of genetic variabilityKleber S Parreira
Division of Nephrology, Université Catholique de Louvain Medical School, 10 Avenue Hippocrate, 1200, Brussels, Belgium
Pflugers Arch 458:745-59. 2009..5) and progressive increase to adult levels, similar to the mRNA pattern observed for proximal tubule markers (Megalin, NaPi-IIa, OAT1) and reflecting the continuous increase in renal cortical structures during development...
- Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11R Spoelgen
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, MA 02129, USA
Neuroscience 158:1460-8. 2009....
- Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1Peter Marschang
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Mol Cell Biol 24:3782-93. 2004..Analysis of LRP1b knockout mice may provide further insights into the role of LRP1b as a tumor suppressor and into the mechanisms of cancer development...
- Intrarenal renin angiotensin system revisited: role of megalin-dependent endocytosis along the proximal nephronMarcus Pohl
Institute of Anatomy, Charite Universitatsmedizin, 10115 Berlin, Germany
J Biol Chem 285:41935-46. 2010..AGT was identified as a ligand of the multiple ligand-binding repeats of megalin. AGT biosynthesis was restricted to the proximal straight tubule, revealing substantial AGT mRNA expression...
- Renal uptake of different radiolabelled peptides is mediated by megalin: SPECT and biodistribution studies in megalin-deficient miceErik Vegt
Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Eur J Nucl Med Mol Imaging 38:623-32. 2011..The mechanisms of kidney reabsorption of these peptides are incompletely understood, but the scavenger receptor megalin has been shown to play a role in the reabsorption of (111)In-octreotide...
- High-resolution maps of the murine Chromosome 2 region containing the cholesterol gallstone locus, Lith1G Bouchard
The Jackson Laboratory, 600 Main St, Bar Harbor, Maine 04609, USA
Mamm Genome 10:1070-4. 1999..pump (Bsep) also known as sister of P-glycoprotein (Spgp) and the low-density-lipoprotein-receptor-related gene megalin (Gp330). Both genetic maps were in agreement and ordered the microsatellite markers into a 10.4 +/- 1.5 cM region...
- The inositol Inpp5k 5-phosphatase affects osmoregulation through the vasopressin-aquaporin 2 pathway in the collecting systemEileen Pernot
Institut de Recherches Interdisciplinaires en Biologie Humaine et Moléculaire, Brussels, Belgium
Pflugers Arch 462:871-83. 2011..Altogether, our results indicate that Inpp5k 5-phosphatase is important for the control of the arginine vasopressin/aquaporin-2 signalling pathway and water transport in kidney collecting ducts...
- Tubular up-regulation of clusterin mRNA in murine lupus-like nephritisS Moll
Department of Internal Medicine, University of Geneva Medical School, Switzerland
Am J Pathol 152:953-62. 1998....
- Mapping of three members of the mouse protein disulfide isomerase familyV Briquet-Laugier
Lipid Research Laboratory, West Los Angeles Veterans Administration Medical Center, Los Angeles, California 90073, USA
Mamm Genome 9:176-7. 1998
- A novel family of Cys-Cys, His-Cys zinc finger transcription factors expressed in developing nervous system and pituitary glandY Jiang
Department of Medicine, Howard Hughes Medical Institute, La Jolla, California, USA
J Biol Chem 271:10723-30. 1996..Identification of a second mouse gene highly homologous to NZF-1, encoded by a distinct genomic locus, reveals a dispersed gene family encoding proteins containing Cys-Cys, His-Cys motifs...
- Mapping of the glycoprotein 330 (Gp330) gene to mouse chromosome 2Y R Xia
Department of Medicine, University of California, Los Angeles 90024
Genomics 17:780-1. 1993b>Glycoprotein 330 (Gp330) is a member of the low-density lipoprotein receptor gene family that is expressed in the kidney. We have mapped the Gp330 gene to mouse chromosome 2, 4...
- Gp330 is specifically expressed in outer cells during epithelial differentiation in the preimplantation mouse embryoC Gueth-Hallonet
Departement de Biologie du Developpement, Institut Jacques Monod, CNRS Université Paris VII, France
Development 120:3289-99. 1994..In this work, we have investigated the expression of gp330, a 330 x 10(3) M(r) glycoprotein found in clathrin-coated areas of the plasma membrane of some epithelial cells ..
- In situ hybridization mapping of a 500-kDa calcium-sensing protein gene (LRP2) to human chromosome region 2q31-->q32.1 and porcine chromosome region 15q22-->q24B P Chowdhary
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala
Cytogenet Cell Genet 71:120-3. 1995Recently, a 500-kDa protein, with homology to the rat Gp330 glycoprotein, was found to be expressed on the surface of human parathyroid, placental cytotrophoblast, and renal proximal tubule cells...
- Midbody and primary cilium of neural progenitors release extracellular membrane particles enriched in the stem cell marker prominin-1Veronique Dubreuil
Max Planck Institute of Molecular Cell Biology and Genetics, D 01307 Dresden, Germany
J Cell Biol 176:483-95. 2007....
- Megalin is a receptor for apolipoprotein M, and kidney-specific megalin-deficiency confers urinary excretion of apolipoprotein MKirsten Faber
Department of Clinical Biochemistry, Univeristy of Lund, University Hospital, Malmo, Sweden
Mol Endocrinol 20:212-8. 2006..In this study, we show that the multiligand receptor megalin, which is expressed in kidney proximal tubule cells, is a receptor for apoM and mediates its uptake in the kidney...
- Role of endocytosis in cellular uptake of sex steroidsAnnette Hammes
Max Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany
Cell 122:751-62. 2005..Contrary to the free hormone hypothesis, we demonstrate that megalin, an endocytic receptor in reproductive tissues, acts as a pathway for cellular uptake of biologically active ..
- Ubiquitous and kidney-specific subunits of vacuolar H+-ATPase are differentially expressed during nephrogenesisFrancois Jouret
Division of Nephrology, Universite Catholique de Louvain, 10 Avenue Hippocrate, Brussels, Belgium B 1200
J Am Soc Nephrol 16:3235-46. 2005..They provide new insights into the complex regulation of V-ATPase subunits, the maturation of IC along the nephron, and the pathophysiology of hereditary dRTA...
- Megalin-mediated reuptake of retinol in the kidneys of mice is essential for vitamin A homeostasisJens Raila
Institute of Nutritional Science, University of Potsdam, D 14558 Nuthetal Bergholz Rehbruecke, Germany
J Nutr 135:2512-6. 2005..reuptake of retinol (ROH) and retinol-binding protein (RBP) in the kidneys is mediated by the endocytic receptor megalin, suggesting an important role for this receptor in vitamin A (VA) metabolism...
- Impaired PTH-induced endocytotic down-regulation of the renal type IIa Na+/Pi-cotransporter in RAP-deficient mice with reduced megalin expressionDesa Bacic
Institute of Physiology, University of Zurich, 8057 Zurich, Switzerland
Pflugers Arch 446:475-84. 2003..b>Megalin is involved in receptor-mediated endocytosis of proteins from the urine in the renal proximal tubule...
- Megalin mediates selenoprotein P uptake by kidney proximal tubule epithelial cellsGary E Olson
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Biol Chem 283:6854-60. 2008..Ligand blotting assays of kidney membrane preparations fractionated by SDS-PAGE revealed that Sepp1 binds megalin, a lipoprotein receptor localized to the proximal tubule epithelium...
- Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor moleculeHelle Heibroch Petersen
Max Delbrueck Center for Molecular Medicine and Medical Faculty of the Free University of Berlin, Germany
J Cell Sci 116:453-61. 2003b>Megalin is a member of the LDL receptor gene family that plays an important role in forebrain development and in cellular vitamin D metabolism through endocytic uptake of vitamin D metabolites...
- Intraperitoneal administration of recombinant receptor-associated protein causes phosphaturia via an alteration in subcellular distribution of the renal sodium phosphate co-transporterMasayo Yamagata
Department of Environmental Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health, 840 Murodo cho, Izumi, Osaka 594 1101, Japan
J Am Soc Nephrol 16:2338-45. 2005b>Megalin is a multifunctional endocytic receptor that is expressed in renal proximal tubules and plays critical roles in the renal uptake of various proteins...
- Soluble megalin is accumulated in the lumen of the rat endolymphatic sacTetsuya Ishida
Department of Histology and Cell Biology, School of Medicine, Kagawa University, Miki, Kagawa 761 0793, Japan
Cell Struct Funct 31:77-85. 2006..b>Megalin is a 600-kDa multiligand endocytic receptor expressed in certain types of absorptive epithelia including kidney ..
- Essential role of RGS-PX1/sorting nexin 13 in mouse development and regulation of endocytosis dynamicsBin Zheng
Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093 0651, USA
Proc Natl Acad Sci U S A 103:16776-81. 2006..compartments, abundant autophagic vacuoles, and abnormal localization of several endocytic markers, including megalin, a receptor for nutrients and proteins; ARH, a coat protein that binds megalin; LAMP2; and LC3...
- Disabled-2 is an epithelial surface positioning geneDong Hua Yang
Ovarian Cancer and Tumor Cell Biology Programs, Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
J Biol Chem 282:13114-22. 2007..show here that Dab2 mediates directional trafficking and polarized distribution of cell surface proteins such as megalin and E-cadherin and propose that loss of polarity is the underlying mechanism for the loss of epithelial cell ..
- Endocytosis provides a major alternative pathway for lysosomal biogenesis in kidney proximal tubular cellsRikke Nielsen
Cell Biology, Institute of Anatomy, University of Aarhus, 8000 Aarhus, Denmark
Proc Natl Acad Sci U S A 104:5407-12. 2007..Here we provide evidence for an alternative, efficient secretion-recapture pathway mediated by megalin and exemplified by cathepsin B in kidney proximal convoluted tubules (PCT)...
- Stage-specific association of apolipoprotein A-I and E in developing mouse retinaShingo Kurumada
Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
Invest Ophthalmol Vis Sci 48:1815-23. 2007..To characterize the intercellular lipid transport systems in differentiating retina...
- Abrogation of protein uptake through megalin-deficient proximal tubules does not safeguard against tubulointerstitial injuryFranziska Theilig
Institut für Vegetative Anatomie, Charite Universitatsmedizin Berlin, Philippstrasse 12, 10115 Berlin
J Am Soc Nephrol 18:1824-34. 2007..This concept was tested in a transgenic mouse model with megalin deficiency...
- Megalin-mediated endocytosis of cystatin C in proximal tubule cellsRyohei Kaseda
Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
Biochem Biophys Res Commun 357:1130-4. 2007..Using quartz-crystal microbalance analyses, we demonstrate that cystatin C binds directly to megalin, an endocytic receptor in PTC, in a Ca(+)-dependent manner...
- Preferential megalin-mediated transcytosis of low-hormonogenic thyroglobulin: a control mechanism for thyroid hormone releaseSimonetta Lisi
Department of Endocrinology, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
Proc Natl Acad Sci U S A 100:14858-63. 2003..However, some Tg internalized by megalin bypasses lysosomes and is transcytosed across cells and released into the bloodstream...
- Core 2 GlcNAc modification and megalin ligand-binding activityHeng Zhang
Sphingolipid Expression Laboratory, RIKEN Frontier Research System, Wako, Saitama, Japan
Biochim Biophys Acta 1780:479-85. 2008b>Megalin, a receptor-like transporter glycoprotein, is expressed on kidney proximal tubular cells and reabsorbs small-molecular-weight proteins from the glomerular filtrate...
- Late gestational lung hypoplasia in a mouse model of the Smith-Lemli-Opitz syndromeHongwei Yu
Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, STR 541, 114 Doughty Street, Charleston, SC 29403, USA
BMC Dev Biol 4:1. 2004..Although they have a number of biochemical and structural abnormalities, one cause of death is from apparent respiratory failure due to developmental pulmonary abnormalities...
- Kidney-specific inactivation of the megalin gene impairs trafficking of renal inorganic sodium phosphate cotransporter (NaPi-IIa)Sebastian Bachmann
Department of Anatomy, Charite, University Medical School of Berlin, Campus Mitte, Philippstrasse 12, D 10098 Berlin, Germany
J Am Soc Nephrol 15:892-900. 2004..The key elements triggering this process are not clear to date. Megalin serves as a receptor for the endocytosis of multiple ligands and is coexpressed with NaPi-IIa in the proximal ..
- A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical developmentKonstantinos Zarbalis
Department of Neurology and the Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, USA
PLoS Biol 2:E219. 2004..Our results also highlight the utility of focused screens in the mouse, in addition to the large-scale and broadly targeted screens that are being carried out at mutagenesis centers...
- Aquaporin-4 is expressed in basolateral membranes of proximal tubule S3 segments in mouse kidneyA N van Hoek
Program in Membrane Biology Renal Unit and Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Physiol Renal Physiol 278:F310-6. 2000..The functional significance of the apparent species-dependent expression of AQP4 in proximal tubules is unknown, but may relate to physiological differences between rats and mice...
- Thyroid dysfunction in megalin deficient miceSimonetta Lisi
Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
Mol Cell Endocrinol 236:43-7. 2005b>Megalin mediates transcytosis of thyroglobulin (Tg), the thyroid hormone precursor, resulting in its passage into the bloodstream...
- Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse modelM Mehrabian
Department of Medicine, University of California, Los Angeles, California 90095, USA
J Clin Invest 101:2485-96. 1998..Finally, they support the existence of specific genetic interactions between body fat, insulin metabolism, and lipoprotein metabolism...
- Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubulesErik I Christensen
Institute of Anatomy, Department of Cell Biology, University of Aarhus, DK 8000 Aarhus C, Denmark
Proc Natl Acad Sci U S A 100:8472-7. 2003..whether this endocytic failure could primarily reflect a loss of reabsorption by the multiligand receptors, megalin, and cubilin, caused by a trafficking defect...
- beta2-glycoprotein-I (apolipoprotein H) and beta2-glycoprotein-I-phospholipid complex harbor a recognition site for the endocytic receptor megalinS K Moestrup
Department of Medical Biochemistry, University of Aarhus, 8000 Aarhus C
J Clin Invest 102:902-9. 1998..beta2-glycoprotein-I/apolipoprotein H as a plasma component binding to the renal epithelial endocytic receptor megalin. A calcium-dependent megalin-mediated beta2-glycoprotein-I endocytosis was subsequently demonstrated by ligand ..
- Evidence for an essential role of megalin in transepithelial transport of retinolE I Christensen
Department of Cell Biology, Institute of Anatomy, University of Aarhus, Denmark
J Am Soc Nephrol 10:685-95. 1999..Analysis of mice with target disruption of the gene for the major endocytic receptor of proximal tubules, megalin, revealed no RBP in proximal tubules of these mice...
- Renal uptake of myoglobin is mediated by the endocytic receptors megalin and cubilinJakub Gburek
Dept of Cell Biology, Institute of Anatomy, Aarhus University, Denmark
Am J Physiol Renal Physiol 285:F451-8. 2003..Here, we report that the endocytic receptors megalin and cubilin are involved in renal reabsorption of myoglobin...
- Expression of the type IV collagenase system during mouse kidney development and tubule segmentationB Legallicier
INSERM U489, Tenon Hospital and St Antoine Medical Faculty, Paris 6 University, Paris, France
J Am Soc Nephrol 12:2358-69. 2001..kidneys; and a two-step immunoperoxidase labeling procedure using specific markers of proximal tubule (megalin), ascending limb of Henle's loop (Tamm Horsfall protein), and collecting duct (Dolichos biflorus agglutinin ..
- Microarray analysis of E9.5 reduced folate carrier (RFC1; Slc19a1) knockout embryos reveals altered expression of genes in the cubilin-megalin multiligand endocytic receptor complexJanee Gelineau-van Waes
Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198 5455, USA
BMC Genomics 9:156. 2008..The identification of alterations in gene expression and signaling pathways involved in the observed dysmorphology following inactivation of RFC1-mediated folate transport are the focus of this investigation...
- Dynamic expression of Lrp2 pathway members reveals progressive epithelial differentiation of primitive endoderm in mouse blastocystFrançois Gerbe
INSERM, UMR384, Faculte de Medecine, 28 place H Dunant BP38, Clermont Ferrand 63001, Universite d Auvergne, Clermont Fd, France
Dev Biol 313:594-602. 2008..In this work, we isolated Lrp2 as a novel PrE precursor (pre-PrE) marker by using a microarray strategy that combines a transcriptome analysis of ..
- Identification of megalin/gp330 as a receptor for lipoprotein(a) in vitroA Niemeier
Medical Clinic, University Hospital Eppendorf, Hamburg, Germany
Arterioscler Thromb Vasc Biol 19:552-61. 1999..In this report, we show that the low density lipoprotein receptor (LDLR) gene family member megalin/glycoprotein (gp) 330 is capable of binding and mediating the cellular uptake and degradation of Lp(a) in vitro...
- Expression profiling confirms the role of endocytic receptor megalin in renal vitamin D3 metabolismJan Hilpert
Max Delbrueck Center for Molecular Medicine and Medical Faculty of the Free University of Berlin, Berlin, Germany
Kidney Int 62:1672-81. 2002The endocytic receptor megalin constitutes the major pathway for clearance of low-molecular weight plasma proteins from the glomerular filtrate into the renal proximal tubules...
- Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transductionM Gotthardt
Department of Molecular Genetics and Pathology, University of Texas Southwestern Medical Center, Dallas 75390 9046, USA
J Biol Chem 275:25616-24. 2000..They form the basis for the elucidation of the molecular pathways by which cells respond to the diversity of ligands that bind to these multifunctional receptors on the cell surface...
- Estrogen and the inner ear: megalin knockout mice suffer progressive hearing lossOvidiu König
Universitäts HNO Klinik, Elfriede Aulhorn Strasse 5, D 72076 Tubingen, Germany
FASEB J 22:410-7. 2008b>Megalin, the largest member of the low-density lipoprotein receptor-related protein family, functions as an endocytic receptor for a variety of essential lipophilic metabolites, including the steroid hormone estrogen...
- Megalin deficiency induces critical changes in mouse spinal cord developmentGrzegorz Wicher
Department of Neuroscience, Neuroanatomy, Biomedical Center, Uppsala University, Uppsala, Sweden
Neuroreport 19:559-63. 2008Low density lipoprotein receptor-related protein, megalin, is a multifunctional lipoproptein receptor expressed by absorptive epithelia for endocytosis of numerous ligands...
- NUTRITIONAL AND METABOLIC SIGNIFICANCE OF SELENIUMRaymond Burk; Fiscal Year: 2003..These and other studies are proposed to evaluate the role of Se-P in protecting endothelial cells (and other cells) against oxidant substances in the extracellular space. ..
- Human Se Nutritional Requirement and Biomarkers in Health and DiseaseRaymond F Burk; Fiscal Year: 2010..All these studies are aimed at facilitating efforts to determine the health effects of selenium deficiency and to guide supplementation of the element when that is needed. ..
- ETHANOL, RETINOIDS, AND CONGENITAL HEART MALFORMATIONSJanee Gelineau van Waes; Fiscal Year: 2003..abstract_text> ..
- SPERM FUNCTION IN FERTILIZATION EVENTSGary Olson; Fiscal Year: 2006..3: To determine if eFGL binding to specific sperm ligands promotes sperm death and/or death cocoon polymerization.4: To define the function of eFGL by targeted disruption of the fgl2 gene in mice. ..
- Role of Selenoprotein P in Male FertilityGary Olson; Fiscal Year: 2007..unreadable] Aim 3: To identify and localize Se-P-binding proteins in the testis and epididymis. [unreadable] Aim 4: To determine the molecular basis for sperm defects in Se-P null mice. [unreadable] [unreadable]..