Lpar3

Summary

Gene Symbol: Lpar3
Description: lysophosphatidic acid receptor 3
Alias: Edg7, lpA3, lysophosphatidic acid receptor 3, LPA receptor 3, LPA-3, endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 7, lysophosphatidic acid receptor Edg-7
Species: mouse

Top Publications

  1. ncbi The mouse lp(A3)/Edg7 lysophosphatidic acid receptor gene: genomic structure, chromosomal localization, and expression pattern
    J J Contos
    Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
    Gene 267:243-53. 2001
  2. pmc Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior
    J J Contos
    Department of Pharmacology, Neuroscience Graduate Program, Biomedical Sciences Program, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0636, USA
    Proc Natl Acad Sci U S A 97:13384-9. 2000
  3. pmc LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing
    Xiaoqin Ye
    Department of Molecular Biology, Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 435:104-8. 2005
  4. pmc Lysophosphatidic acid-induced vascular neointimal formation in mouse carotid arteries is mediated by the matricellular protein CCN1/Cyr61
    Feng Hao
    Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee
    Am J Physiol Cell Physiol 311:C975-C984. 2016
  5. pmc Deletion of Lysophosphatidic Acid Receptor 3 (Lpar3) Disrupts Fine Local Balance of Progesterone and Estrogen Signaling in Mouse Uterus During Implantation
    Honglu Diao
    Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, Georgia Reproductive Medical Center, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, China
    Biol Reprod 93:123. 2015
  6. pmc Lysophosphatidic acid and its receptors LPA1 and LPA3 mediate paclitaxel-induced neuropathic pain in mice
    Hitoshi Uchida
    Department of Pharmacology and Therapeutic Innovation, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Mol Pain 10:71. 2014
  7. pmc RBPJ in mouse Sertoli cells is required for proper regulation of the testis stem cell niche
    Thomas Xavier Garcia
    Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Unit 1105, PO Box 301402, Houston, TX 77230 1402, USA Department of Comparative Biosciences, University of Illinois at Urbana Champaign, Urbana, IL 61802, USA
    Development 141:4468-78. 2014
  8. pmc Lysophosphatidic acid acts as a nutrient-derived developmental cue to regulate early hematopoiesis
    Haisen Li
    State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell biology Shanghai Institutes for Biological Sciences Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Shanghai, China
    EMBO J 33:1383-96. 2014
  9. pmc Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity
    Marion David
    From the INSERM, UMR1033, UCB Lyon 1, Faculté de médecine Lyon Est, 69732 Lyon, France
    J Biol Chem 289:6551-64. 2014
  10. doi Downregulation of activation factors of endothelia and fibroblasts via lysophosphatidic acid signaling in a mouse lung cancer LL/2 cell line
    Eriko Tanabe
    Division of Cancer Biology and Bioinformatics and
    J Recept Signal Transduct Res 33:286-90. 2013

Scientific Experts

  • Xiaoqin Ye
  • Hiroshi Ueda
  • H Ohuchi
  • Honglu Diao
  • Jerold Chun
  • Shuo Xiao
  • Rong Li
  • Fei Zhao
  • Kotaro Hama
  • Feng Hao
  • Junken Aoki
  • Hiroyuki Arai
  • Hitoshi Uchida
  • Thomas Xavier Garcia
  • Marion David
  • Haisen Li
  • Eriko Tanabe
  • Toshifumi Tsujiuchi
  • Nobuyuki Fukushima
  • Daisuke Furuta
  • Chenqi Zhao
  • J J Contos
  • Yona Goldshmit
  • Adrienne E Dubin
  • Pallavi Subramanian
  • Ryota Itoh
  • Liana C Chan
  • Nattapon Panupinthu
  • Tomoko Endo
  • Asuka Inoue
  • Tomokazu Amano
  • Hiroshi Suzuki
  • Masayuki Tanaka
  • Susanna Wang
  • Laurens A van Meeteren
  • Takeshi Yamada
  • Anja U Bräuer
  • Xuemin Xu
  • Dong An
  • Guohong Li
  • Daniel Dongwei Wu
  • Mei Zhen Cui
  • Fuqiang Zhang
  • Jing Shi
  • Elizabeth A Dudley
  • Ahmed E El Zowalaty
  • Jiulin Du
  • Ruben Lopez Vales
  • Edith Bonnelye
  • Gang Pei
  • Johnny Ribeiro
  • Penelope Ottewell
  • Irma Machuca-Gayet
  • Raphael Leblanc
  • Marie Claude Hofmann
  • Olivier Peyruchaud
  • Ge Gao
  • Rui Yue
  • Philippe Clezardin
  • Bin Wei
  • Jun Nagai
  • Masaru Ishii
  • Christine McGiffert
  • Pierre Jurdic
  • Fuka Mima
  • Jaspreet Kaur Farmaha
  • Ingunn Holen
  • Sean Kow
  • Junichi Kikuta
  • Federica Di Palma
  • Mutsumi Araki
  • Mary B Ard
  • Elizabeth W Howerth
  • Misaho Kitayoshi
  • Miku Hirane
  • Yan Dong
  • Ryutaro Moriyama
  • Masayuki Yamane
  • Shiyou Chen
  • Zuguo Li
  • J Chun
  • Maria J Fernandes
  • John D Aplin
  • Sylvain G Bourgoin
  • Patrice E Poubelle
  • Anne Sardella
  • Andreas Schober
  • Christian Weber
  • Deron R Herr
  • Alice Pebay

Detail Information

Publications34

  1. ncbi The mouse lp(A3)/Edg7 lysophosphatidic acid receptor gene: genomic structure, chromosomal localization, and expression pattern
    J J Contos
    Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
    Gene 267:243-53. 2001
    ..To understand the evolution and function of LPA receptor genes, we characterized lp(A3)/Edg7 in mouse and human and compared the expression pattern with the other two known LPA receptor genes (lp(A1)/Edg2 and ..
  2. pmc Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior
    J J Contos
    Department of Pharmacology, Neuroscience Graduate Program, Biomedical Sciences Program, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0636, USA
    Proc Natl Acad Sci U S A 97:13384-9. 2000
    ..Our results provide evidence that endogenous lysophospholipid signaling requires an lp receptor gene and indicate that LPA signaling through the LP(A1) receptor is required for normal development of an inborn, neonatal behavior...
  3. pmc LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing
    Xiaoqin Ye
    Department of Molecular Biology, Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 435:104-8. 2005
    ..we report a newly discovered molecular influence on implantation through the lysophosphatidic acid (LPA) receptor LPA3 (refs 2-4)...
  4. pmc Lysophosphatidic acid-induced vascular neointimal formation in mouse carotid arteries is mediated by the matricellular protein CCN1/Cyr61
    Feng Hao
    Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee
    Am J Physiol Cell Physiol 311:C975-C984. 2016
    ..CCN1 may serve as an important vascular disease marker and potential target for vascular therapeutic intervention...
  5. pmc Deletion of Lysophosphatidic Acid Receptor 3 (Lpar3) Disrupts Fine Local Balance of Progesterone and Estrogen Signaling in Mouse Uterus During Implantation
    Honglu Diao
    Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, Georgia Reproductive Medical Center, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, China
    Biol Reprod 93:123. 2015
    b>Lpar3 encodes LPA3, the third G protein-coupled receptor for lysophosphatidic acid (LPA). Lpar3(-/-) female mice had delayed embryo implantation...
  6. pmc Lysophosphatidic acid and its receptors LPA1 and LPA3 mediate paclitaxel-induced neuropathic pain in mice
    Hitoshi Uchida
    Department of Pharmacology and Therapeutic Innovation, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Mol Pain 10:71. 2014
    ..Previously, we have demonstrated that lysophosphatidic acid (LPA) and its receptors (LPA1 and LPA3) are required for the initiation of peripheral nerve injury-induced neuropathic pain...
  7. pmc RBPJ in mouse Sertoli cells is required for proper regulation of the testis stem cell niche
    Thomas Xavier Garcia
    Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Unit 1105, PO Box 301402, Houston, TX 77230 1402, USA Department of Comparative Biosciences, University of Illinois at Urbana Champaign, Urbana, IL 61802, USA
    Development 141:4468-78. 2014
    ....
  8. pmc Lysophosphatidic acid acts as a nutrient-derived developmental cue to regulate early hematopoiesis
    Haisen Li
    State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell biology Shanghai Institutes for Biological Sciences Graduate School of the Chinese Academy of Sciences Chinese Academy of Sciences, Shanghai, China
    EMBO J 33:1383-96. 2014
    ..Taken together, we identified LPA as an important nutrient-derived developmental cue for primitive hematopoiesis as well as a novel mechanism of hemangioblast regulation. ..
  9. pmc Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity
    Marion David
    From the INSERM, UMR1033, UCB Lyon 1, Faculté de médecine Lyon Est, 69732 Lyon, France
    J Biol Chem 289:6551-64. 2014
    ..that bone marrow cell-induced osteoclastogenesis was reduced in Lpar1(-/-) mice but not in Lpar2(-/-) and Lpar3(-/-) animals...
  10. doi Downregulation of activation factors of endothelia and fibroblasts via lysophosphatidic acid signaling in a mouse lung cancer LL/2 cell line
    Eriko Tanabe
    Division of Cancer Biology and Bioinformatics and
    J Recept Signal Transduct Res 33:286-90. 2013
    ..In this study, to assess an involvement of LPA3 on angiogenesis and fibroblast activation, the Lpar3-expressing cells were generated from mouse lung cancer LL/2 cells, which unexpressed LPA3...
  11. pmc Broad gap junction blocker carbenoxolone disrupts uterine preparation for embryo implantation in mice
    Honglu Diao
    Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, Georgia 30602, USA
    Biol Reprod 89:31. 2013
    ..These data demonstrate that uterine gap junctions are important for embryo implantation. ..
  12. ncbi A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting
    Anja U Bräuer
    Institute of Anatomy, Department of Cell Biology and Neurobiology, Philippstr 12, Humboldt University Medical School Charité, D 10115 Berlin, Germany
    Nat Neurosci 6:572-8. 2003
    ..Thus, we propose a novel mechanism by which axons are able to control phospholipid-mediated signaling and overcome the growth-inhibiting, phospholipid-rich environment of the extracellular space...
  13. pmc Distinct spatiotemporal expression of serine proteases Prss23 and Prss35 in periimplantation mouse uterus and dispensable function of Prss35 in fertility
    Honglu Diao
    Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, Georgia, United States of America
    PLoS ONE 8:e56757. 2013
    ..This study demonstrates the distinct expression of Prss23 and Prss35 in the periimplantation uterus and the dispensable role of Prss35 in fertility and embryo development...
  14. pmc 11-deoxy prostaglandin F(2α), a thromboxane A2 receptor agonist, partially alleviates embryo crowding in Lpar3((-/-)) females
    Xiaoqin Ye
    Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, Georgia 30602, USA
    Fertil Steril 97:757-63. 2012
    To determine cyclooxygenase-derived prostanoid signaling in alleviating embryo crowding in the Lpar3((-/-)) females.
  15. doi Lysophosphatidic acid induces neurite branch formation through LPA3
    Daisuke Furuta
    Division of Molecular Neurobiology, Department of Life Science, Kinki University, Higashiosaka, Japan
    Mol Cell Neurosci 50:21-34. 2012
    ..These findings suggest that the novel signaling pathway involving LPA(3), G(q), and Rnd2 may play an important role in neuronal network formation...
  16. pmc TNF-alpha promotes LPA1- and LPA3-mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines
    Chenqi Zhao
    Rheumatology and Immunology Research Center, CHUQ CHUL Research Center and Faculty of Medicine, Laval University, Quebec City, Quebec, Canada
    J Lipid Res 52:1307-18. 2011
    ..We suggest that LPA, via LPA(1) and LPA(3) receptors, may play a significant role in inducing and/or sustaining the massive infiltration of leukocytes during inflammation...
  17. ncbi Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p(1) in neurogenesis and s1p(1-3) in angiogenesis
    Christine McGiffert
    Neurosciences Graduate Program, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
    FEBS Lett 531:103-8. 2002
    ..The punctate pattern colocalized with vascular endothelial markers. Together, these results suggest that s1p(1) influences neurogenesis and s1p(1-3) influence angiogenesis in the developing brain...
  18. pmc Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice
    Federica Di Palma
    Section on Neurogenetics, Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 99:14994-9. 2002
    ..Hence, we identify a molecular link between hair cell physiology and melanocyte function. Last, MCOLN2 and MCOLN3 are candidate genes for hereditary and/or sporadic forms of neurosensory disorders in humans...
  19. ncbi Physical and functional interactions of the lysophosphatidic acid receptors with PDZ domain-containing Rho guanine nucleotide exchange factors (RhoGEFs)
    Takeshi Yamada
    School of Allied Health Sciences, Faculty of Medicine, Osaka University, Yamadaoka, Suita Shi, Osaka 565 0871, Japan
    J Biol Chem 280:19358-63. 2005
    ..responses in various cells via heterotrimeric G protein-coupled receptors (GPCRs) including LPA1, LPA2, and LPA3. LPA-induced cytoskeletal changes are mediated by Rho family small GTPases, such as RhoA, Rac1, and Cdc42...
  20. pmc Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity
    Susanna Wang
    Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    PLoS Genet 2:e15. 2006
    ..These data have implications on the potential effects of sex on the genetic regulation of other complex traits...
  21. pmc Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development
    Laurens A van Meeteren
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Mol Cell Biol 26:5015-22. 2006
    ....
  22. ncbi Lysophosphatidic receptor, LPA3, is positively and negatively regulated by progesterone and estrogen in the mouse uterus
    Kotaro Hama
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Life Sci 79:1736-40. 2006
    ..These results show that progesterone and estrogen cooperatively regulate LPA(3) expression, thereby contributing to the receptivity of uteri during early pregnancy...
  23. ncbi Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid
    Masayuki Tanaka
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 281:25822-30. 2006
    ..The present study revealed a previously unassigned role of ATX in stabilizing vessels through novel LPA signaling pathways...
  24. ncbi P2X7 nucleotide receptors mediate blebbing in osteoblasts through a pathway involving lysophosphatidic acid
    Nattapon Panupinthu
    Canadian Institutes of Health Research Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, The University of Western Ontario, London, Canada
    J Biol Chem 282:3403-12. 2007
    ..This pathway may contribute to P2X7-stimulated osteogenesis during skeletal development and mechanotransduction...
  25. pmc Unique uterine localization and regulation may differentiate LPA3 from other lysophospholipid receptors for its role in embryo implantation
    Xiaoqin Ye
    Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA
    Fertil Steril 95:2107-13, 2113.e1-4. 2011
    To determine factors differentiating LPA3 from other lysophospholipid (LP) receptors for its role in embryo implantation.
  26. pmc Altered spatiotemporal expression of collagen types I, III, IV, and VI in Lpar3-deficient peri-implantation mouse uterus
    Honglu Diao
    Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA
    Biol Reprod 84:255-65. 2011
    b>Lpar3 is upregulated in the preimplantation uterus, and deletion of Lpar3 leads to delayed uterine receptivity in mice. Microarray analysis revealed that there was higher expression of Col3a1 and Col6a3 in the Preimplantation Day 3...
  27. pmc Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis
    Adrienne E Dubin
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 30:7300-9. 2010
    ..Compared with other known factors, lysophospholipids represent the major activator of calcium signaling identified within NPCs at this early stage in corticogenesis...
  28. doi LPA receptor expression in the central nervous system in health and following injury
    Yona Goldshmit
    Centre for Neuroscience, The University of Melbourne, Melbourne, Victoria, Australia
    Cell Tissue Res 341:23-32. 2010
    ..LPA release following CNS injury may have different consequences for each cell type because of this differential expression in the adult nervous system...
  29. doi Stimulatory actions of lysophosphatidic acid on mouse ATDC5 chondroprogenitor cells
    Ryota Itoh
    Department of Cellular Differentiation, Institute for Frontier Medical Sciences, Kyoto University, Sakyo ku, Kyoto, Japan
    J Bone Miner Metab 28:659-71. 2010
    ..These results indicate that LPA plays an important role in the activation of chondroprogenitor cells...
  30. doi Lysophosphatidic acid receptors LPA1 and LPA3 promote CXCL12-mediated smooth muscle progenitor cell recruitment in neointima formation
    Pallavi Subramanian
    Institute for Molecular Cardiovascular Research, RWTH Aachen University, Pauwelsstr 30 52074 Aachen, Germany
    Circ Res 107:96-105. 2010
    ..Lysophosphatidic acid (LPA) induces CXCL12 and neointimal accumulation of smooth muscle cells (SMCs) in uninjured arteries. Thus, we hypothesize that LPA may regulate CXCL12-mediated vascular remodelling...
  31. doi Expression patterns of the lysophospholipid receptor genes during mouse early development
    Hideyo Ohuchi
    Department of Life Systems, Institute of Technology and Science, University of Tokushima, Tokushima, Japan
    Dev Dyn 237:3280-94. 2008
    ..genes, which belong to the G protein-coupled receptor (GPCR) family: EDG1 to EDG8 (S1P1 to S1P5 and LPA1 to LPA3), LPA4 (GPR23/P2Y9), and LPA5 (GPR92)...
  32. pmc Age-dependent loss of sperm production in mice via impaired lysophosphatidic acid signaling
    Xiaoqin Ye
    Department of Molecular Biology, The Helen L Dorris Child and Adolescent Neuropsychiatric Disorder Institute, The Scripps Research Institute, La Jolla, California 92037, USA
    Biol Reprod 79:328-36. 2008
    ..Germ cell apoptosis led to a reduction in germ cell proliferation. These data demonstrate a novel in vivo function for LPA signaling as a germ cell survival factor during spermatogenesis...
  33. ncbi Embryo spacing and implantation timing are differentially regulated by LPA3-mediated lysophosphatidic acid signaling in mice
    Kotaro Hama
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113 0033, Japan
    Biol Reprod 77:954-9. 2007
    ..the establishment of early pregnancy by affecting embryo spacing and subsequent implantation through its receptor, LPA3. Targeted deletion of Lpa3 in mice resulted in delayed implantation and embryo crowding, which is associated with a ..
  34. ncbi LPA3 receptor mediates chemotaxis of immature murine dendritic cells to unsaturated lysophosphatidic acid (LPA)
    Liana C Chan
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    J Leukoc Biol 82:1193-200. 2007
    ..In summary, our results indicate that immature mouse DCs migrate preferentially in response to unsaturated LPA and that LPA(3) is important in this response...