Lmf1

Summary

Gene Symbol: Lmf1
Description: lipase maturation factor 1
Alias: 2400010G15Rik, AW822050, Tmem112, cld, lipase maturation factor 1, transmembrane protein 112
Species: mouse

Top Publications

  1. ncbi Expression of lipoprotein lipase gene in combined lipase deficiency
    K Oka
    Medlantic Research Foundation, Washington, DC 20010
    Biochim Biophys Acta 1008:351-4. 1989
  2. pmc Embryonic viability, lipase deficiency, hypertriglyceridemia and neonatal lethality in a novel LMF1-deficient mouse model
    Nicole Ehrhardt
    Medical Genetics Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Nutr Metab (Lond) 11:37. 2014
  3. pmc The ER-associated degradation adaptor protein Sel1L regulates LPL secretion and lipid metabolism
    Haibo Sha
    Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA
    Cell Metab 20:458-70. 2014
  4. pmc Lipase maturation factor 1 (lmf1) is induced by endoplasmic reticulum stress through activating transcription factor 6α (Atf6α) signaling
    Hui Z Mao
    From the Medical Genetics Research Institute and
    J Biol Chem 289:24417-27. 2014
  5. pmc Transgenic expression and genetic variation of Lmf1 affect LPL activity in mice and humans
    Maryam Hosseini
    Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Arterioscler Thromb Vasc Biol 32:1204-10. 2012
  6. ncbi Differential effect of combined lipase deficiency (cld/cld) on human hepatic lipase and lipoprotein lipase secretion
    J C Boedeker
    Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    J Lipid Res 42:1858-64. 2001
  7. pmc Lipase maturation factor 1 is required for endothelial lipase activity
    Osnat Ben-Zeev
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    J Lipid Res 52:1162-9. 2011
  8. pmc Lipase maturation factor LMF1, membrane topology and interaction with lipase proteins in the endoplasmic reticulum
    Mark H Doolittle
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 284:33623-33. 2009
  9. pmc A quantitative assay measuring the function of lipase maturation factor 1
    Fen Yin
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 50:2265-9. 2009
  10. ncbi Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia
    Miklos Peterfy
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Nat Genet 39:1483-7. 2007

Scientific Experts

  • Miklos Peterfy
  • Nicole Ehrhardt
  • Mark H Doolittle
  • Maryam Hosseini
  • Hui Z Mao
  • Osnat Ben-Zeev
  • Fen Yin
  • Candy Bedoya
  • Haibo Sha
  • Andre Bensadoun
  • Ching Mei Lai
  • Howard Wong
  • Sander Kersten
  • Zhen Xue
  • Ling Qi
  • Qiaoming Long
  • Imran N Mungrue
  • Javier A Gomez
  • J Thomas Brenna
  • Bingzhong Xue
  • Peter Lawrence
  • Frits Mattijssen
  • Lei Liu
  • Diane Dezwaan-McCabe
  • Randal J Kaufman
  • Robert D Guber
  • Hang Shi
  • Muhammad S Panhwar
  • Adam B Francisco
  • Shengyi Sun
  • D Thomas Rutkowski
  • Daphna Weissglas-Volkov
  • Paivi Pajukanta
  • Jo Ling Liao
  • Elina Nikkola
  • Marja Riitta Taskinen
  • J C Boedeker
  • Maurizio R Averna
  • Angelo B Cefalù
  • Davide Noto
  • C J Schultz
  • Jo Ling-Liao
  • Saskia B Neher
  • Peter Walter
  • R O Scow
  • Ciara M Gallagher
  • M H Doolittle
  • E J Blanchette-Mackie
  • J W Park
  • K Reue
  • A L White
  • F Lai
  • K Artzt
  • J R Paterniti
  • K Oka
  • T Ebersole
  • W V Brown
  • R C Davis
  • T Olivecrona
  • D Martin
  • O Ben-Zeev
  • M Senda
  • A S Masibay
  • P K Oasba
  • P K Qasba
  • S S Chernick
  • H N Ginsberg
  • J G Yuan
  • T Nakano
  • G T Tkalcevic
  • H Masuno
  • G Bengtsson-Olivecrona

Detail Information

Publications20

  1. ncbi Expression of lipoprotein lipase gene in combined lipase deficiency
    K Oka
    Medlantic Research Foundation, Washington, DC 20010
    Biochim Biophys Acta 1008:351-4. 1989
    ..gene for lipoprotein lipase (LPL) was studied in brown adipose tissue and the liver of combined lipase deficient (cld/cld) and unaffected mice. The mRNA specific for LPL was detected in both animals...
  2. pmc Embryonic viability, lipase deficiency, hypertriglyceridemia and neonatal lethality in a novel LMF1-deficient mouse model
    Nicole Ehrhardt
    Medical Genetics Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Nutr Metab (Lond) 11:37. 2014
    b>Lipase Maturation Factor 1 (LMF1) is an ER-chaperone involved in the post-translational maturation and catalytic activation of vascular lipases including lipoprotein lipase (LPL), hepatic lipase (HL) and endothelial lipase (EL)...
  3. pmc The ER-associated degradation adaptor protein Sel1L regulates LPL secretion and lipid metabolism
    Haibo Sha
    Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA
    Cell Metab 20:458-70. 2014
    ..Sel1L physically interacts with and stabilizes the LPL maturation complex consisting of LPL and lipase maturation factor 1 (LMF1)...
  4. pmc Lipase maturation factor 1 (lmf1) is induced by endoplasmic reticulum stress through activating transcription factor 6α (Atf6α) signaling
    Hui Z Mao
    From the Medical Genetics Research Institute and
    J Biol Chem 289:24417-27. 2014
    b>Lipase maturation factor 1 (Lmf1) is a critical determinant of plasma lipid metabolism, as demonstrated by severe hypertriglyceridemia associated with its mutations in mice and human subjects...
  5. pmc Transgenic expression and genetic variation of Lmf1 affect LPL activity in mice and humans
    Maryam Hosseini
    Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Arterioscler Thromb Vasc Biol 32:1204-10. 2012
    ..A lipase-chaperone, lipase maturation factor 1 (Lmf1), has recently emerged as a critical factor in this process...
  6. ncbi Differential effect of combined lipase deficiency (cld/cld) on human hepatic lipase and lipoprotein lipase secretion
    J C Boedeker
    Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    J Lipid Res 42:1858-64. 2001
    Combined lipase deficiency (cld) is a recessively inherited disorder in mice associated with a deficiency of LPL and hepatic lipase (HL) activity...
  7. pmc Lipase maturation factor 1 is required for endothelial lipase activity
    Osnat Ben-Zeev
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    J Lipid Res 52:1162-9. 2011
    b>Lipase maturation factor 1 (Lmf1) is an endoplasmic reticulum (ER) membrane protein involved in the posttranslational folding and/or assembly of lipoprotein lipase (LPL) and hepatic lipase (HL) into active enzymes...
  8. pmc Lipase maturation factor LMF1, membrane topology and interaction with lipase proteins in the endoplasmic reticulum
    Mark H Doolittle
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 284:33623-33. 2009
    b>Lipase maturation factor 1 (LMF1) is predicted to be a polytopic protein localized to the endoplasmic reticulum (ER) membrane...
  9. pmc A quantitative assay measuring the function of lipase maturation factor 1
    Fen Yin
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 50:2265-9. 2009
    ..This factor has been identified as lipase maturation factor 1 (Lmf1), and mutations affecting its function and/or expression result in combined lipase deficiency (cld)..
  10. ncbi Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia
    Miklos Peterfy
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Nat Genet 39:1483-7. 2007
    ..Here we identify the gene containing the cld mutation as Tmem112 and rename it Lmf1 (Lipase maturation factor 1)...
  11. ncbi The cld mutation: narrowing the critical chromosomal region and selecting candidate genes
    Miklos Peterfy
    Department of Medicine, University of California, Los Angeles, Los Angeles, California, 90095, USA
    Mamm Genome 17:1013-24. 2006
    Combined lipase deficiency (cld) is a recessive, lethal mutation specific to the tw73 haplotype on mouse Chromosome 17...
  12. pmc New molecular markers for the distal end of the t-complex and their relationships to mutations affecting mouse development
    T Ebersole
    Department of Zoology, University of Texas, Austin 78712 1064
    Genetics 131:175-82. 1992
    ..to the t-complex: two cosmids map between H-2K and Crya-1, setting a distal limit in t-haplotypes for the position of the tw5 lethal, one is inseparable from the tw12 lethal, and one maps distal to tf near the t0(t6) lethal and cld.
  13. ncbi Adrenal and liver in normal and cld/cld mice synthesize and secrete hepatic lipase, but the lipase is inactive in cld/cld mice
    C J Schultz
    Laboratory of Cellular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Lipid Res 41:214-25. 2000
    Combined lipase deficiency (cld) is a recessive mutation in mice that causes a severe lack of lipoprotein lipase (LPL) and hepatic lipase (HL) activities, hyperlipemia, and death within 3 days after birth...
  14. ncbi Naturally occurring mutations in mice affecting lipid transport and metabolism
    K Reue
    Lipid Research Laboratory, West Los Angeles VA Medical Center, CA, USA
    J Lipid Res 37:1387-405. 1996
    ..provide a more in-depth discussion of two mutations, fatty liver dystrophy (fld) and combined lipase deficiency (cld)...
  15. pmc Brefeldin A enables synthesis of active lipoprotein lipase in cld/cld and castanospermine-treated mouse brown adipocytes via translocation of Golgi components to endoplasmic reticulum
    J W Park
    Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Biochem J 317:125-34. 1996
    Brown adipocytes cultured from newborn combined-lipase-deficient (cld/cld) mice and castanospermine (CST)-treated 3T3-L1 adipocytes synthesize lipoprotein lipase (LPL) which is inactive and retained in the endoplasmic reticulum (ER) [..
  16. ncbi Combined lipase deficiency (cld): a lethal mutation on chromosome 17 of the mouse
    J R Paterniti
    Science 221:167-9. 1983
    ..A single recessive mutation, cld, on mouse chromosome 17 causes an apparent deficiency of both lipoprotein lipase and hepatic triglyceride lipase ..
  17. ncbi Combined lipase deficiency (cld/cld) in mice. Demonstration that an inactive form of lipoprotein lipase is synthesized
    T Olivecrona
    J Biol Chem 260:2552-7. 1985
    Combined lipase deficiency, cld, is a recessive mutation within the T/t complex of mouse chromosome 17. Mice homozygous for this defect display severe functional deficiencies of lipoprotein lipase and the related hepatic lipase...
  18. ncbi Combined lipase deficiency in the mouse. Evidence of impaired lipase processing and secretion
    R C Davis
    Lipid Research, Veterans Administration Wadsworth Medical Center, Los Angeles, California 90073
    J Biol Chem 265:17960-6. 1990
    Newborn combined lipase-deficient (cld) mice have severe hypertriglyceridemia associated with a marked decrease of lipoprotein lipase (LPL) and hepatic lipase (HL) activities...
  19. ncbi Molecular cloning of mouse hepatic triacylglycerol lipase: gene expression in combined lipase-deficient (cld/cld) mice
    K Oka
    Laboratory of Molecular Genetics, Medlantic Research Foundation, Washington DC
    Biochim Biophys Acta 1089:13-20. 1991
    ..Combined lipase deficiency (cld) is a recessive mutation in mice, which causes the functional deficiency of HL and lipoprotein lipase, the isolated ..
  20. ncbi Map positions of four dinucleotide repeats in the mouse t complex
    F Lai
    Department of Zoology, University of Texas, Austin 78712 1064
    Mamm Genome 3:476-7. 1992