Lhx1

Summary

Gene Symbol: Lhx1
Description: LIM homeobox protein 1
Alias: Lim1, LIM/homeobox protein Lhx1, LIM homeo box protein 1, homeobox protein Lim-1
Species: mouse

Top Publications

  1. ncbi Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis
    Y Mishina
    Department of Molecular Genetics, University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Genes Dev 9:3027-37. 1995
  2. ncbi HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo
    A Perea-Gomez
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, BP163, CU de Strasbourg, France
    Development 126:4499-511. 1999
  3. ncbi Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula
    J A Belo
    Department of Biological Chemistry, Howard Hughes Medical Institute, University of California, Los Angeles 90095 1662, USA
    Mech Dev 68:45-57. 1997
  4. ncbi Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling
    J Ericson
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Cell 90:169-80. 1997
  5. ncbi dILA neurons in the dorsal spinal cord are the product of terminal and non-terminal asymmetric progenitor cell divisions, and require Mash1 for their development
    Hendrik Wildner
    Max Delbrück Centrum for Molecular Medicine, Berlin Buch, Germany
    Development 133:2105-13. 2006
  6. ncbi Expression patterns of developmental control genes in normal and Engrailed-1 mutant mouse spinal cord reveal early diversity in developing interneurons
    M P Matise
    New York University Medical School, Skirball Institute of Biomolecular Medicine, Developmental Genetics Program, New York, New York 10016, USA
    J Neurosci 17:7805-16. 1997
  7. pmc FOXC1 is required for normal cerebellar development and is a major contributor to chromosome 6p25.3 Dandy-Walker malformation
    Kimberly A Aldinger
    Committee on Neurobiology, University of Chicago, Chicago, Illinois, USA
    Nat Genet 41:1037-42. 2009
  8. pmc Tight regulation of p53 activity by Mdm2 is required for ureteric bud growth and branching
    Sylvia Hilliard
    Tulane University School of Medicine, Department of Pediatrics, Section of Pediatric Nephrology, Orleans, LA 70112, USA
    Dev Biol 353:354-66. 2011
  9. ncbi Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis
    J D Barnes
    Howard Hughes Medical Institute, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
    Dev Biol 161:168-78. 1994
  10. ncbi Specific expression of the LIM/homeodomain protein Lim-1 in horizontal cells during retinogenesis
    W Liu
    Graduate Program in Microbiology and Molecular Genetics, UMDNJ Robert Wood Johnson Medical School, Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey 08854, USA
    Dev Dyn 217:320-5. 2000

Research Grants

Scientific Experts

Detail Information

Publications135 found, 100 shown here

  1. ncbi Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis
    Y Mishina
    Department of Molecular Genetics, University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Genes Dev 9:3027-37. 1995
    ....
  2. ncbi HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo
    A Perea-Gomez
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, BP163, CU de Strasbourg, France
    Development 126:4499-511. 1999
    ..Here, we report that HNF3beta and Lim1 are coexpressed in both organising centers suggesting synergistic roles of these genes in regulating organiser ..
  3. ncbi Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula
    J A Belo
    Department of Biological Chemistry, Howard Hughes Medical Institute, University of California, Los Angeles 90095 1662, USA
    Mech Dev 68:45-57. 1997
    ..In addition to cer-l, anterior visceral endoderm was found to express the transcription factors Lim1, goosecoid and HNF-3beta that are also present in trunk organizer cells...
  4. ncbi Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling
    J Ericson
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Cell 90:169-80. 1997
    ..2. Pax6 establishes distinct ventral progenitor cell populations and controls the identity of motor neurons and ventral interneurons, mediating graded Shh signaling in the ventral spinal cord and hindbrain...
  5. ncbi dILA neurons in the dorsal spinal cord are the product of terminal and non-terminal asymmetric progenitor cell divisions, and require Mash1 for their development
    Hendrik Wildner
    Max Delbrück Centrum for Molecular Medicine, Berlin Buch, Germany
    Development 133:2105-13. 2006
    ..Our data allow us to assign to Mash1 a function in asymmetric cell divisions, and indicate that the factor coordinates cell cycle exit and specification in the one daughter that gives rise to a dILA neuron...
  6. ncbi Expression patterns of developmental control genes in normal and Engrailed-1 mutant mouse spinal cord reveal early diversity in developing interneurons
    M P Matise
    New York University Medical School, Skirball Institute of Biomolecular Medicine, Developmental Genetics Program, New York, New York 10016, USA
    J Neurosci 17:7805-16. 1997
    ..Rather, it is suggested that En-1 may function to distinguish a subset of interneurons during the later maturation of the spinal cord...
  7. pmc FOXC1 is required for normal cerebellar development and is a major contributor to chromosome 6p25.3 Dandy-Walker malformation
    Kimberly A Aldinger
    Committee on Neurobiology, University of Chicago, Chicago, Illinois, USA
    Nat Genet 41:1037-42. 2009
    ..Our results highlight a previously unrecognized role for mesenchyme-neuroepithelium interactions in the mid-hindbrain during early embryogenesis...
  8. pmc Tight regulation of p53 activity by Mdm2 is required for ureteric bud growth and branching
    Sylvia Hilliard
    Tulane University School of Medicine, Department of Pediatrics, Section of Pediatric Nephrology, Orleans, LA 70112, USA
    Dev Biol 353:354-66. 2011
    ..These results demonstrate a critical and cell autonomous role for Mdm2 in the UB lineage. Mdm2-mediated inhibition of p53 activity is a prerequisite for renal organogenesis...
  9. ncbi Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis
    J D Barnes
    Howard Hughes Medical Institute, Vanderbilt University School of Medicine, Nashville, Tennessee 37232
    Dev Biol 161:168-78. 1994
    ..These data suggest that in the mouse embryo Lim-1 plays a role in early mesoderm formation and later specification of a differentiated phenotype in subsets of cells of the mesonephros and sensory neurons of the CNS...
  10. ncbi Specific expression of the LIM/homeodomain protein Lim-1 in horizontal cells during retinogenesis
    W Liu
    Graduate Program in Microbiology and Molecular Genetics, UMDNJ Robert Wood Johnson Medical School, Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey 08854, USA
    Dev Dyn 217:320-5. 2000
    ..These data together suggest a possible role for Lim-1 in terminal differentiation and maintenance of horizontal cells, and that Lim-1 can serve as a specific molecular marker for the study of horizontal cell specification...
  11. ncbi Targeting of the EphA4 tyrosine kinase receptor affects dorsal/ventral pathfinding of limb motor axons
    F Helmbacher
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, 75230 Paris Cedex 05, France
    Development 127:3313-24. 2000
    ..Our data therefore suggest that the level of EphA4 protein in growing limb motor axons is involved in the selection of dorsal versus ventral trajectories, thus contributing to the topographic organisation of motor projections...
  12. ncbi Crossinhibitory activities of Ngn1 and Math1 allow specification of distinct dorsal interneurons
    K Gowan
    Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuron 31:219-32. 2001
    ..experiments, expression of Math1 or Ngn1 in dorsal progenitor cells determines whether LH2A/B- or dorsal Lim1/2-expressing interneurons will develop...
  13. pmc Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord
    Yuko Muroyama
    Kondoh Differentiation Signaling Project, Exploratory Research for Advanced Technology ERATO, Japan Science and Technology Corporation JST, Kinki Invention Center, Sakyo ku, Kyoto 606 8305, Japan
    Genes Dev 16:548-53. 2002
    ..Thus, Wnt signaling plays a critical role in the specification of cell types for dorsal interneurons...
  14. ncbi Gsh2 is required for the repression of Ngn1 and specification of dorsal interneuron fate in the spinal cord
    Sonja Kriks
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Development 132:2991-3002. 2005
    ..Our results provide evidence that genetic interactions involving repression of Ngn1 by Gsh2 promote the differentiation of dI3 neurons from class A progenitors...
  15. ncbi Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development
    Akio Kobayashi
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Development 132:2809-23. 2005
    ..The LIM-class homeobox gene Lim1 is expressed in the intermediate mesoderm, nephric duct, mesonephric tubules, ureteric bud, pretubular aggregates ..
  16. ncbi Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation
    S L Pfaff
    Howard Hughes Medical Institute, Department of Biochemistry and Molecule Biophysics, Columbia University, New York, New York 10032, USA
    Cell 84:309-20. 1996
    ..These results show that ISL1 is required for the generation of motor neurons and suggest that motor neuron generation is required for the subsequent differentiation of certain interneurons...
  17. ncbi Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo
    J Ding
    Center for Advanced Biotechnology and Medicine and Dept of Pediatrics, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Nature 395:702-7. 1998
    ..Our results indicate that Cripto signalling is essential for the conversion of a proximal-distal asymmetry into an orthogonal anterior-posterior axis...
  18. ncbi Retinaldehyde dehydrogenase 2 and Hoxc8 are required in the murine brachial spinal cord for the specification of Lim1+ motoneurons and the correct distribution of Islet1+ motoneurons
    Julien Vermot
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, BP 10142, 67404 Illkirch Cedex, C U de Strasbourg, France
    Development 132:1611-21. 2005
    ..Mutant (Raldh2L-/-) embryos display an early embryonic loss of a subset of Lim1+ brachial motoneurons, a mispositioning of Islet1+ neurons and inappropriate axonal projections of one of the ..
  19. ncbi Requirement for Lim1 in head-organizer function
    W Shawlot
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Nature 374:425-30. 1995
    b>Lim1 is a homeobox gene expressed in the organizer region of mouse embryos. To investigate the role of Lim1 during embryogenesis, a targeted deletion of the Lim1 gene was generated in embryonic stem cells...
  20. ncbi HNF-3 beta is essential for node and notochord formation in mouse development
    S L Ang
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Cell 78:561-74. 1994
    ..HNF-3 beta is not required for the development of definitive endoderm cells, but foregut morphogenesis is severely affected in HNF-3 beta -/- embryos...
  21. ncbi A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain
    S L Ang
    Institute de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Illkirch, C U de Strasbourg, France
    Development 122:243-52. 1996
    ....
  22. ncbi Expression of murine Lhx5 suggests a role in specifying the forebrain
    H Z Sheng
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Dev Dyn 208:266-77. 1997
    ..Lhx5 is also expressed in midbrain, hindbrain, and spinal cord, overlapping extensively with Lhx1 starting from day E10.5 of gestation...
  23. ncbi Progenitors of dorsal commissural interneurons are defined by MATH1 expression
    A W Helms
    Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    Development 125:919-28. 1998
    ..Taken together, we demonstrate MATH1 expression in a differentiating population of neuronal precursors in the dorsal neural tube that appear to give rise specifically to dorsal commissural interneurons...
  24. ncbi Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation
    D Acampora
    International Institute of Genetics and Biophysics, CNR, Via G Marconi 12, Italy
    Development 125:5091-104. 1998
    ..Moreover, our data lead us to hypothesize that the differential post-transcriptional control existing between VE and epiblast cells may potentially contribute to fundamental regulatory mechanisms required for head specification...
  25. ncbi Pax3 and Pax7 are expressed in commissural neurons and restrict ventral neuronal identity in the spinal cord
    A Mansouri
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg 11, 37077, Gottingen, Germany
    Mech Dev 78:171-8. 1998
    ..Our findings reveal two distinct regulatory pathways for spinal cord neurogenesis, only one of which is dependent on Pax3/7 and 6...
  26. ncbi Requirement for Wnt3 in vertebrate axis formation
    P Liu
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Genet 22:361-5. 1999
    ..These studies provide genetic proof for the requirement of Wnt3 in primary axis formation in the mouse...
  27. ncbi Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity
    S Arber
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Neuron 23:659-74. 1999
    ..These findings show that HB9 has an essential function in consolidating the identity of postmitotic MNs...
  28. pmc Requirement for beta-catenin in anterior-posterior axis formation in mice
    J Huelsken
    Max Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany
    J Cell Biol 148:567-78. 2000
    ..5, as visualized by the absence of Hex and Hesx1 and the mislocation of cerberus-like and Lim1 expression. Subsequently, no mesoderm and head structures are generated...
  29. ncbi Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification
    K J Lee
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Centre for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Nature 403:734-40. 2000
    ..These results reveal that the roof plate is essential for specifying multiple classes of neurons in the mammalian central nervous system...
  30. ncbi Coordinate roles for LIM homeobox genes in directing the dorsoventral trajectory of motor axons in the vertebrate limb
    A Kania
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Cell 102:161-73. 2000
    ..We show that two LIM homeodomain transcription factors, Lim1 and Lmx1b, control the initial trajectory of motor axons in the developing mammalian limb...
  31. ncbi Nodal signalling in the epiblast patterns the early mouse embryo
    J Brennan
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nature 411:965-9. 2001
    ..Our experiments show that proximal-distal and subsequent anterior-posterior polarity of the pregastrulation embryo result from reciprocal cell-cell interactions between the epiblast and the two extra-embryonic tissues...
  32. ncbi Conditional inactivation of Lim1 function
    Kin Ming Kwan
    Department of Molecular Genetics, University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genesis 32:118-20. 2002
  33. ncbi Lbx1 specifies somatosensory association interneurons in the dorsal spinal cord
    Michael K Gross
    Molecular Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuron 34:535-49. 2002
    ..Lbx1, therefore, plays a critical role in the development of sensory pathways in the spinal cord that relay pain and touch...
  34. ncbi The homeodomain factor lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord
    Thomas Muller
    Department of Medical Genetics, Max Delbruck Center for Molecular Medicine, 13122 Berlin, Germany
    Neuron 34:551-62. 2002
    ..We conclude that Lbx1 distinguishes two major neuronal classes in the dorsal spinal cord and is an important determinant of their distinct differentiation programs...
  35. pmc Nephric lineage specification by Pax2 and Pax8
    Maxime Bouchard
    Research Institute of Molecular Pathology, Vienna Biocenter, A 1030 Vienna, Austria
    Genes Dev 16:2958-70. 2002
    ..transitions required for nephric duct formation, fails to initiate the kidney-specific expression of Lim1 and c-Ret, and is lost by apoptosis 1 d after failed pronephric induction...
  36. ncbi Extraembryonic proteases regulate Nodal signalling during gastrulation
    Séverine Beck
    Developmental Biology Group, Swiss Institute for Experimental Cancer Research ISREC, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nat Cell Biol 4:981-5. 2002
    ..A lack of Spc1 and Spc4 affects both pathways because these proteases also stimulate induction of Bmp4...
  37. ncbi Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity
    Jen Chih Hsieh
    Department of Biochemistry and Cell Biology, Center for Developmental Genetics, State University of New York, Stony Brook, Stony Brook, NY 11794, USA
    Cell 112:355-67. 2003
    ....
  38. ncbi Dynamic spatiotemporal expression of LIM genes and cofactors in the embryonic and postnatal cerebral cortex
    Sarada Bulchand
    Tata Institute of Fundamental Research, Mumbai, India
    Dev Dyn 226:460-9. 2003
    ..These results suggest multiple and distinct roles for LIM-HD, Lmo, and Clim genes in cortical development, and also support a LIM-HD-independent role for some Lmo and Clim members...
  39. ncbi Topographic motor projections in the limb imposed by LIM homeodomain protein regulation of ephrin-A:EphA interactions
    Artur Kania
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Neuron 38:581-96. 2003
    ..These topographic projections are established, in part, through LIM homeodomain protein control of EphA receptors and ephrin-A ligands in motor neurons and limb mesenchymal cells...
  40. ncbi Contribution of Hox genes to the diversity of the hindbrain sensory system
    Gary O Gaufo
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Development 131:1259-66. 2004
    ..More generally, these findings contribute to our understanding of how Hox genes specifically control cellular diversity in the developing organism..
  41. ncbi The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice
    Olivia G Kelly
    Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720 3200, USA
    Development 131:2803-15. 2004
    ..The effect of reducing, but not eliminating, Wnt signaling in Lrp5(+/-);Lrp6(-/-) mutant embryos provides important insight into the interplay between Wnt, Fgf and Nodal signals in patterning the early mouse embryo...
  42. ncbi Foxn4 controls the genesis of amacrine and horizontal cells by retinal progenitors
    Shengguo Li
    Center for Advanced Biotechnology and Medicine and Department of Pediatrics, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 679 Hoes Lane, Piscataway, NJ 08854 USA
    Neuron 43:795-807. 2004
    ..Our data suggest a model in which Foxn4 cooperates with other key retinogenic factors to mediate the multipotent differentiation of retinal progenitors...
  43. ncbi Homeodomain transcription factors in the development of subsets of hindbrain reticulospinal neurons
    Ana C Cepeda-Nieto
    Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Queretaro 76230, Mexico
    Mol Cell Neurosci 28:30-41. 2005
    ..of reticulospinal neurons in chick and mouse embryos combined with immunostaining for the homeodomain factors Lhx1/Lhx5, Lhx3/Lhx4, and Chx10 have defined transcriptional codes that label subsets of neurons with different axon ..
  44. pmc The bHLH factor Olig3 coordinates the specification of dorsal neurons in the spinal cord
    Thomas Muller
    Max Delbruck Center for Molecular Medicine, 13122 Berlin, Germany
    Genes Dev 19:733-43. 2005
    ..We conclude that Olig3 expression distinguishes the two major classes of progenitors in the dorsal spinal cord and determines the distinct specification program of class A neurons...
  45. pmc Sequential roles for Mash1 and Ngn2 in the generation of dorsal spinal cord interneurons
    Amy W Helms
    Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Development 132:2709-19. 2005
    ..Thus, bHLH factors, particularly Mash1 and related family members Math1 and Ngn1, provide a code for generating neuronal diversity in the dorsal spinal cord with Ngn2 serving to modulate the number of neurons in each population formed...
  46. ncbi FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons
    Uta Grieshammer
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143 2711, USA
    Development 132:3847-57. 2005
    ..In the absence of FGF8 signaling, nephron formation is initiated, but the nascent nephrons do not express Wnt4 or Lim1, and nephrogenesis does not progress to the S-shaped body stage...
  47. ncbi Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system
    Thomas J Carroll
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Dev Cell 9:283-92. 2005
    ..Together these findings suggest that Wnt9b is a common organizing signal regulating diverse components of the mammalian urogenital system...
  48. ncbi Lim 1 is required for nephric duct extension and ureteric bud morphogenesis
    Anissa Pedersen
    Department of Genetics, Cell Biology and Development and University of Minnesota Developmental Biology Center, University of Minnesota, 6 160 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
    Dev Biol 288:571-81. 2005
    ..These results suggest that Lim 1 influences nephric duct extension and ureteric bud outgrowth by regulating and or maintaining the differentiation of the nephric epithelium...
  49. ncbi Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes
    Leping Cheng
    Dana Farber Cancer Institute, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
    Nat Neurosci 8:1510-5. 2005
    ..These genetic studies suggest that Lbx1 expression defines a basal GABAergic differentiation state, and Tlx3 acts to antagonize Lbx1 to promote glutamatergic differentiation...
  50. ncbi Distinct roles for secreted semaphorin signaling in spinal motor axon guidance
    Andrea B Huber
    Howard Hughes Medical Institute, Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 48:949-64. 2005
    ..Thus, Sema3A-Npn-1 and Sema3F-Npn-2 signaling control distinct steps of motor axon growth and guidance during the formation of spinal motor connections...
  51. ncbi Zic3 is critical for early embryonic patterning during gastrulation
    Stephanie M Ware
    Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Dev Dyn 235:776-85. 2006
    ..At later stages, deficiency of Zic3 results in abnormal mesoderm allocation. These results indicate a requirement for Zic3 during early embryogenesis prior to cardiac and visceral organ patterning...
  52. ncbi Sprouty2 is involved in male sex organogenesis by controlling fibroblast growth factor 9-induced mesonephric cell migration to the developing testis
    Lijun Chi
    Department of Biochemistry, University of Oulu, Finland
    Endocrinology 147:3777-88. 2006
    ..Based on these data, we propose that the Sprouty proteins are involved normally in mediating the sexually dimorphic signaling of FGF9 and controlling cell migration from the mesonephros during testis development...
  53. ncbi p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation
    Irene E Zohn
    Howard Hughes Medical Institute, Department of Pediatrics, Section of Developmental Biology, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    Cell 125:957-69. 2006
    ..Finally, p38 regulates E-cadherin protein expression downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by Fibroblast Growth Factor (Fgf) signaling and Snail...
  54. ncbi The roof plate regulates cerebellar cell-type specification and proliferation
    Victor V Chizhikov
    Department of Human Genetics, University of Chicago, 920 E 58th Street, CLSC 319 Chicago, IL 60637, USA
    Development 133:2793-804. 2006
    ..Thus, in addition to the isthmus, the roof plate represents an important signaling center controlling multiple aspects of cerebellar patterning...
  55. pmc Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney
    Michelle Self
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    EMBO J 25:5214-28. 2006
    ..We propose that in the developing kidney, Six2 activity is required for maintaining the mesenchymal progenitor population in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud...
  56. ncbi Ptf1a determines horizontal and amacrine cell fates during mouse retinal development
    Yoshio Fujitani
    Vanderbilt University Program in Developmental Biology and Department of Cell and Developmental Biology, Vanderbilt University Medical School, Nashville, TN 37232 8240, USA
    Development 133:4439-50. 2006
    ..These data, together with the previous findings on Foxn4, provide a model in which the Foxn4-Ptf1a pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine cell fates...
  57. ncbi Molecular markers of neuronal progenitors in the embryonic cerebellar anlage
    Daniver Morales
    Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York 10021 6399, USA
    J Neurosci 26:12226-36. 2006
    ..These results identify molecular pathways that offer new insights on the development of the nuclear and cortical structures of the cerebellum, as well as components of the cerebellar circuitry...
  58. ncbi Lhx1 and Lhx5 maintain the inhibitory-neurotransmitter status of interneurons in the dorsal spinal cord
    Andrea Pillai
    Biology Graduate Program, University of California, San Diego, La Jolla, CA 92037, USA
    Development 134:357-66. 2007
    b>Lhx1 and Lhx5 are co-expressed in multiple interneuron cell types in the developing spinal cord...
  59. ncbi Pax2 and pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney
    Melina Narlis
    McGill Cancer Centre and Biochemistry Department, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada
    J Am Soc Nephrol 18:1121-9. 2007
    ..the molecular analysis of Pax2(+/-)Pax8(+/-) kidneys reveals a strong reduction in the expression levels of Lim1, a key regulator of nephron differentiation, accompanied by an increase in apoptosis...
  60. ncbi Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development
    Joo Seop Park
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 134:2533-9. 2007
    ..However, the failure of induced mesenchyme with high levels of beta-catenin activity to form epithelial structures suggests that modulating canonical signaling may be crucial for the cellular transition to the renal vesicle...
  61. pmc LIM-homeodomain proteins Lhx1 and Lhx5, and their cofactor Ldb1, control Purkinje cell differentiation in the developing cerebellum
    Yangu Zhao
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 2790, USA
    Proc Natl Acad Sci U S A 104:13182-6. 2007
    ..Here we report that two closely related LIM-homeobox genes, Lhx1 and Lhx5, were expressed in the developing Purkinje cells soon after they exited the cell cycle and migrated out of ..
  62. ncbi Lim1 is essential for the correct laminar positioning of retinal horizontal cells
    Ross A Poche
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 27:14099-107. 2007
    ..The LIM class homeodomain transcription factor Lim1 (Lhx1) is expressed in postmitotic, differentiating, and mature retinal horizontal cells...
  63. doi Canonical WNT/beta-catenin signaling is required for ureteric branching
    Darren Bridgewater
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    Dev Biol 317:83-94. 2008
    ..5. Microarray analysis of E12.5 kidney tissue identified decreased Emx2 and Lim1 expression among a small subset of renal patterning genes disrupted at the stage of abnormal branching...
  64. pmc Somal positioning and dendritic growth of horizontal cells are regulated by interactions with homotypic neighbors
    Ross A Poche
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA
    Eur J Neurosci 27:1607-14. 2008
    ..To test this directly, we have employed the Cre-loxP conditional gene targeting strategy to achieve inactivation of Lim1 function in developing horizontal cells...
  65. doi Identification of a novel transcriptional corepressor, Corl2, as a cerebellar Purkinje cell-selective marker
    Yasuko Minaki
    KAN Research Institute Inc, KobeMI R and D Center, 6 7 3 Minatojima minamimachi, Chuo Ku, Kobe, Hyogo 650 0047, Japan
    Gene Expr Patterns 8:418-23. 2008
    ..Furthermore, this marker was useful for unmasking the precise origin of PCs and delineating the domain map within the ventricular zone that generates cerebellar GABAergic neurons...
  66. pmc Newly identified patterns of Pax2 expression in the developing mouse forebrain
    Vassiliki Fotaki
    Genes and Development Group, Centres for Integrative Physiology and Neuroscience Research, School of Biomedical Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK
    BMC Dev Biol 8:79. 2008
    ..5, and become part of the eminentia thalami by E11.5. The discovery of this previously undescribed cell population prompted us to examine Pax2 protein expression in the developing mouse forebrain in more detail...
  67. doi A transcriptional network coordinately determines transmitter and peptidergic fate in the dorsal spinal cord
    Dominique Bröhl
    Department of Neuroscience, Max Delbrück Centrum for Molecular Medicine, Berlin, Germany
    Dev Biol 322:381-93. 2008
    ..Inhibitory neurons of the dorsal horn derive from postmitotic neurons that express Pax2, Lbx1 and Lhx1/5, and diversify during maturation...
  68. doi The bHLH transcription factor Olig3 marks the dorsal neuroepithelium of the hindbrain and is essential for the development of brainstem nuclei
    Robert Storm
    Max Delbrück Centrum for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Development 136:295-305. 2009
    ..We therefore propose that Olig3 can cooperate with Ptf1a to determine the fate of climbing fiber neurons of the inferior olivary nucleus...
  69. doi Specification of motor axon trajectory by ephrin-B:EphB signaling: symmetrical control of axonal patterning in the developing limb
    Victor Luria
    Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Neuron 60:1039-53. 2008
    ..The involvement of ephrin:Eph signaling in guiding both sets of motor axons raises the possibility that other signaling systems function primarily to refine or modulate a core Eph signaling program...
  70. pmc Identification and subclassification of new Atoh1 derived cell populations during mouse spinal cord development
    George R Miesegaes
    Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Biol 327:339-51. 2009
    ..Altogether we reveal the existence of multiple Atoh1 dependent cell types in the spinal cord, and uncover a novel progenitor domain that arises late in development...
  71. pmc Transcription factor Gbx2 acts cell-nonautonomously to regulate the formation of lineage-restriction boundaries of the thalamus
    Li Chen
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Development 136:1317-26. 2009
    ..We propose that, within the developing thalamus, the dynamic and differential expression of Gbx2 may be involved in the specific segregation of thalamic neurons, leading to partition of the thalamus into different nuclei...
  72. doi SRC family kinases are required for limb trajectory selection by spinal motor axons
    Tzu Jen Kao
    Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada
    J Neurosci 29:5690-700. 2009
    ..In summary, our findings demonstrate that SFKs are essential for motor axon guidance and suggest that they play an important role in relaying ephrin:Eph signals that mediate the selection of motor axon trajectory in the limb...
  73. doi Differential expression of LIM-homeodomain factors in Cajal-Retzius cells of primates, rodents, and birds
    Antonio Abellan
    Laboratory of Brain Development and Evolution, Department of Experimental Medicine, Faculty of Medicine, University of Lleida, Institute of Biomedical Research of Lleida, 25008 Lleida, Spain
    Cereb Cortex 20:1788-98. 2010
    ..We have investigated the expression of the LIM-hd members Lhx1/Lhx2/Lhx5/Lhx6/Lhx9 in the reelin-expressing cells, the pallium, and the regions of origin of CR cells including ..
  74. pmc Lhx1 controls terminal differentiation and circadian function of the suprachiasmatic nucleus
    Joseph L Bedont
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Cell Rep 7:609-22. 2014
    ..Here, we show that Lim homeodomain transcription factor 1 (Lhx1) is essential for terminal differentiation and function of the SCN...
  75. ncbi Defects of urogenital development in mice lacking Emx2
    N Miyamoto
    Department of Morphogenesis, Institute of Molecular Embryology and Genetics IMEG, Kumamoto University School of Medicine, Honjo, Japan
    Development 124:1653-64. 1997
    ..Subsequently, however, Pax-2, c-ret and Lim1 expressions in the ureteric bud and GDNF expression in the mesenchyme were greatly reduced...
  76. ncbi Pax-6 functions in boundary formation and axon guidance in the embryonic mouse forebrain
    G S Mastick
    Department of Biology, University of Michigan, Ann Arbor 48109, USA
    Development 124:1985-97. 1997
    ..We conclude that Pax-6 plays multiple roles in forebrain patterning, including boundary formation, regional patterning, neuron specification and axon guidance...
  77. ncbi Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification
    M Rhinn
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Strasbourg, France
    Development 125:845-56. 1998
    ..Altogether, these results demonstrate that Otx2 is first required in the visceral endoderm for the induction, and subsequently in the neuroectoderm for the specification of forebrain and midbrain territories...
  78. pmc The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice
    X Yang
    Laboratory of Biochemistry and Metabolism, 10 9N105, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:3667-72. 1998
    ..Altogether, these data demonstrate that SMAD4-mediated signals are required for epiblast proliferation, egg cylinder formation, and mesoderm induction...
  79. pmc Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2
    M Weinstein
    Laboratory of Biochemistry and Metabolism, National Institute of Diabetes and Digestive and Kidney Diseases, 10 9N105, 10 Center Drive, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:9378-83. 1998
    ..Molecular analysis showed that smad2 mutant embryos did not undergo gastrulation or make mesoderm. The results demonstrate that smad2 is required for egg cylinder elongation, gastrulation, and mesoderm induction...
  80. ncbi Forebrain and midbrain development requires epiblast-restricted Otx2 translational control mediated by its 3' UTR
    P P Boyl
    MRC Centre for Developmental Neurobiology, King s College London, Guy s Campus, New Hunt s House, London SE1 1UL, UK
    Development 128:2989-3000. 2001
    ..This leads us to hypothesise that this control might have important evolutionary implications...
  81. ncbi OTD/OTX2 functional equivalence depends on 5' and 3' UTR-mediated control of Otx2 mRNA for nucleo-cytoplasmic export and epiblast-restricted translation
    D Acampora
    MRC Centre for Developmental Neurobiology, King s College London, Guy s Campus, New Hunts House, London SE1 9RT, UK
    Development 128:4801-13. 2001
    ..These data provide novel in vivo evidence supporting the concept that during evolution pre-existing gene functions have been recruited into new developmental pathways by modifying their regulatory control...
  82. ncbi Differential requirements for Smad4 in TGFbeta-dependent patterning of the early mouse embryo
    Gerald C Chu
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Development 131:3501-12. 2004
    ..These results suggest that Smad4 potentiates a subset of TGFbeta-related signals during early embryonic development, but is dispensable for others...
  83. ncbi The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4
    Nadav Ben-Haim
    Ecole Polytechnique Fédérale de Lausanne EPFL ISREC, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Dev Cell 11:313-23. 2006
    ..Based on mathematical modeling, we discuss how these sequential loops control cell fate...
  84. ncbi Multiple roles for activin-like kinase-2 signaling during mouse embryogenesis
    Y Mishina
    Department of Molecular Genetics, University of Texas, M D Anderson Cancer Center, Houston, Texas, 77030, USA
    Dev Biol 213:314-26. 1999
    ....
  85. ncbi Cooperation between GDNF/Ret and ephrinA/EphA4 signals for motor-axon pathway selection in the limb
    Edgar R Kramer
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, 82152 Martinsried, Germany
    Neuron 50:35-47. 2006
    ..This phenotype is enhanced in mutant mice lacking Ret and EphA4. Thus, Ret and EphA4 signals cooperate to enforce the precision of the same binary choice in motor-axon guidance...
  86. ncbi Interactions between LIM domains and the LIM domain-binding protein Ldb1
    J J Breen
    Laboratory of Molecular Genetics, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 273:4712-7. 1998
    ..The role of Ldb1 may be to recruit other transcriptional activators depending on the promoter context and LIM-homeodomain partner involved...
  87. ncbi Pax6 regulates the identity of embryonic diencephalic neurons
    G S Mastick
    Department of Biology, University of Nevada, Reno, Nevada 89557, USA
    Mol Cell Neurosci 17:190-207. 2001
    ..neurons expressed combinations of transcription factors, including Pax6, DLX, and the LIM-domain proteins islet-1, Lhx1 (Lim1), and Lhx5 (Lim-2)...
  88. ncbi Mesodermal patterning defect in mice lacking the Ste20 NCK interacting kinase (NIK)
    Y Xue
    New York University Medical Center, Skirball Institute of Biomolecular Medicine, Department of Pharmacology, NY, NY10016, USA
    Development 128:1559-72. 2001
    ....
  89. ncbi Novel transcription factor Satb2 interacts with matrix attachment region DNA elements in a tissue-specific manner and demonstrates cell-type-dependent expression in the developing mouse CNS
    Olga Britanova
    Department of Molecular Biology of Neuronal Signals, Max Planck Institute for Experimental Medicine, 37075 Goettingen, Germany
    Eur J Neurosci 21:658-68. 2005
    ..In the Lbx1 mutants Satb2 expression is greatly reduced. We suggest that Satb2 may regulate differentiation of subsets of neurons at the level of higher order chromatin structure via binding to MARs...
  90. pmc The docking protein FRS2alpha is an essential component of multiple fibroblast growth factor responses during early mouse development
    N Gotoh
    Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Mol Cell Biol 25:4105-16. 2005
    ..These experiments underscore the critical role of FRS2alpha in mediating multiple processes during embryonic development and reveal a potential new link between FGF and Bmp4 signaling pathways in early embryogenesis...
  91. pmc Mice deficient in Ext2 lack heparan sulfate and develop exostoses
    Dominique Stickens
    Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    Development 132:5055-68. 2005
    ..The finding that haploinsufficiency triggers abnormal cartilage differentiation gives insight into the complex molecular mechanisms underlying the development of exostoses...
  92. pmc Lateral motor column axons execute a ternary trajectory choice between limb and body tissues
    Victor Luria
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Neural Dev 2:13. 2007
    ..The cellular logic that guides motor axon trajectory choices into non-limb tissues such as the ventral flank remains unclear...
  93. pmc Functional redundancy of EGF-CFC genes in epiblast and extraembryonic patterning during early mouse embryogenesis
    Jianhua Chu
    Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA
    Dev Biol 342:63-73. 2010
    ..Our results indicate that both Cripto and Cryptic function non-cell-autonomously during normal development, and that most if not all Nodal activity in early mouse embryogenesis is EGF-CFC-dependent...
  94. doi Nucleotide exchange factor RIC-8 is indispensable in mammalian early development
    Tambet Tõnissoo
    Department of Developmental Biology, University of Tartu, Tartu, Estonia
    Dev Dyn 239:3404-15. 2010
    ..Furthermore, the orientation of the Ric-8(-/-) embryo in the uterus was abnormal. Our study reveals that the activity of RIC-8 protein is irreplaceable for the correct gastrulation of mouse embryo...
  95. pmc Pituitary adenylyl cyclase-activating peptide counteracts hedgehog-dependent motor neuron production in mouse embryonic stem cell cultures
    Megumi Hirose
    Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 7332, USA
    J Neurosci Res 89:1363-74. 2011
    ..mice by immunofluorescence, on the other hand, revealed no obvious alterations in expressions of Islet1/2, MNR2, Lim1/2, Nkx2.2, or Shh, although the Pax6-positive area was slightly expanded in PACAP-deficient spinal cord...
  96. pmc Vesicoureteral reflux and other urinary tract malformations in mice compound heterozygous for Pax2 and Emx2
    Sami K Boualia
    Department of Biochemistry and Goodman Cancer Centre, McGill University, Montreal, Quebec, Canada
    PLoS ONE 6:e21529. 2011
    ..As both genes are located on human chromosome 10q, which is lost in a proportion of VUR patients, these findings may help understand VUR and CAKUT in humans...
  97. ncbi Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins
    A D Agulnick
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 384:270-2. 1996
    ..now isolated a new LIM-domain-binding factor, Ldb1, on the basis of its ability to interact with the LIM-HD protein Lhx1 (Lim1)...
  98. ncbi Segmental and neuronal architecture of the hindbrain of Krox-20 mouse mutants
    S Schneider-Maunoury
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Biologie Moléculaire du Développement, Ecole Normale Superieure, Paris, France
    Development 124:1215-26. 1997
    ..This navigational error could explain the disappearance, at around 17.5 dpc, of the trigeminal motor nucleus in Krox-20(-/-) embryos by inadequate supply of essential, possibly arch-specific survival factors...
  99. ncbi Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling
    H Sasaki
    Laboratory of Developmental Biology, Institute for Molecular and Cellular Biology, Osaka University, Suita, Osaka 565 0871, Japan
    Development 126:3915-24. 1999
    ....
  100. ncbi Experimental analysis of the emergence of left-right asymmetry of the body axis in early postimplantation mouse embryos
    T E Tsang
    Embryology Unit, Children s Medical Research Institute, Wentworthville, NSW, Australia
    Cell Mol Biol (Noisy-le-grand) 45:493-503. 1999
    ..of Cerrl, Fgf8, Hesx1 and Hnf3beta gene in the anterior visceral endoderm, Otx2 and Sox2 in the epiblast and Lim1 in the nascent mesoderm...
  101. ncbi Lim1 is required in both primitive streak-derived tissues and visceral endoderm for head formation in the mouse
    W Shawlot
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA edu
    Development 126:4925-32. 1999
    b>Lim1 is a homeobox gene expressed in the extraembryonic anterior visceral endoderm and in primitive streak-derived tissues of early mouse embryos...

Research Grants13

  1. Transcription Factor P53 in Terminal Nephron Different
    Zubaida Saifudeen; Fiscal Year: 2004
    ..The results of this work will provide information on what determines terminal renal differentiation. In addition, these data will advance our understanding of the role the tumor suppressor p53 in kidney development...
  2. PIONEER AXON GUIDANCE IN THE EMBRYONIC FOREBRAIN
    GRANT MASTICK; Fiscal Year: 2004
    ..In addition, the mechanisms of axon growth during development may give insight into how regeneration of the nervous system may be stimulated following trauma or disease. ..
  3. INVESTIGATING THE ROLE OF CDO IN BRAIN DEVELOPMENT
    Ami Okada; Fiscal Year: 2004
    ..These experiments should also contribute to the overall understanding of the signals that are important in the assembly of the nervous system. ..
  4. Legless Transgene Insertion Mutation
    S Potter; Fiscal Year: 2004
    ..The results will provide deeper insight into the genetic program of limb development and might also find function for these genes in the formation of the brain and other organs. ..
  5. Functional Analysis of Spinal Cord Interneurons
    Martyn Goulding; Fiscal Year: 2005
    ..These studies will provide valuable insights into the development and organization of circuits in the spinal cord that control locomotor behavior, and will lay the groundwork for strategies to treat spinal cord injury and degeneration. ..
  6. Zic3 and the Control of Body Pattern Formation
    STEPHANIE WARE; Fiscal Year: 2005
    ..Through a combination of supervised research, scientific interchange, and selected coursework within this environment, the candidate will obtain the training necessary to transition to an independent investigator. ..
  7. Specification of Dorsal Lbx1-Derived Interneurons
    Martyn Goulding; Fiscal Year: 2007
    ..These studies will provide important insights into the development and organization of neural circuits in the dorsal horn that sense and relay pain. [unreadable] [unreadable] [unreadable]..
  8. Resolving the nuclear fusion steps during yeast mating
    Patricia Melloy; Fiscal Year: 2006
    ..This information and the tools used can then be applied to other cell biological and gene regulation questions during other types of membrane fusion. ..
  9. The role of cell polarity in vertebrate limb outgrowth
    Jeffery Barrow; Fiscal Year: 2007
    ..Furthermore he will examine the epistatic relationship between Fgf and Wnt/PCP signaling in regulating cell polarity. [unreadable] [unreadable] [unreadable]..
  10. Development of the Metanephric Mesenchyme
    S Potter; Fiscal Year: 2009
    ..abstract_text> ..
  11. Glomerulosclerosis in Human FSGS and Animal Models
    S Steven Potter; Fiscal Year: 2010
    ....
  12. Longitudinal axon guidance by long range cues in the embryonic brain
    GRANT STEPHEN MASTICK; Fiscal Year: 2011
    ....
  13. Towards renal regeneration
    Melissa Little; Fiscal Year: 2004
    ..Human ES cell work will be performed using ES01, 02, 03, 04, 05 & 06 listed on the NIH ES cell line registry. ..