Lepr

Summary

Gene Symbol: Lepr
Description: leptin receptor
Alias: LEPROT, Leprb, Modb1, OB-RGRP, Obr, diabetes, obese-like, obl, leptin receptor, B219, LEP-R, OB receptor, leptin receptor gene-related protein
Species: mouse

Top Publications

  1. ncbi Localization of leptin receptor mRNA splice variants in murine peripheral tissues by RT-PCR and in situ hybridization
    N Hoggard
    Molecular Physiology Group, Rowett Research Institute, Bucksburn, Aberdeen, United Kingdom
    Biochem Biophys Res Commun 232:383-7. 1997
  2. ncbi Abnormal splicing of the leptin receptor in diabetic mice
    G H Lee
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA
    Nature 379:632-5. 1996
  3. ncbi The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
    Seung Hoi Koo
    Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, California 92037 1002, USA
    Nature 437:1109-11. 2005
  4. ncbi Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
    Nina Balthasar
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue RN, Boston, MA 02215, USA
    Neuron 42:983-91. 2004
  5. ncbi Diabetes, a new mutation in the mouse
    K P Hummel
    Science 153:1127-8. 1966
  6. pmc Leptin targets in the mouse brain
    Michael M Scott
    Division of Hypothalamic Research, Departments of Internal Medicine and Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Comp Neurol 514:518-32. 2009
  7. pmc Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing
    Kazuichi Maruyama
    Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, USA
    Am J Pathol 170:1178-91. 2007
  8. pmc Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balance
    Gina M Leinninger
    Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Metab 14:313-23. 2011
  9. pmc Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues
    H Fei
    Laboratory of Molecular Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 94:7001-5. 1997
  10. ncbi Identification of SOCS-3 as a potential mediator of central leptin resistance
    C Bjørbaek
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell 1:619-25. 1998

Research Grants

Detail Information

Publications195 found, 100 shown here

  1. ncbi Localization of leptin receptor mRNA splice variants in murine peripheral tissues by RT-PCR and in situ hybridization
    N Hoggard
    Molecular Physiology Group, Rowett Research Institute, Bucksburn, Aberdeen, United Kingdom
    Biochem Biophys Res Commun 232:383-7. 1997
    Expression of leptin receptor splice variants, including the long form variant (Ob-Rb), has been examined in murine peripheral tissues...
  2. ncbi Abnormal splicing of the leptin receptor in diabetic mice
    G H Lee
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA
    Nature 379:632-5. 1996
    ..Previous data suggest that the db gene encodes the receptor for the obese (ob) gene product, leptin. A leptin receptor was recently cloned from choroid plexus and shown to map to the same 6-cM interval on mouse chromosome 4 as ..
  3. ncbi The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
    Seung Hoi Koo
    Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, California 92037 1002, USA
    Nature 437:1109-11. 2005
    ..Individuals with type 2 diabetes often exhibit fasting hyperglycaemia due to elevated gluconeogenesis; compounds that enhance TORC2 ..
  4. ncbi Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
    Nina Balthasar
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue RN, Boston, MA 02215, USA
    Neuron 42:983-91. 2004
    ..In summary, leptin receptors on POMC neurons are required but not solely responsible for leptin's regulation of body weight homeostasis...
  5. ncbi Diabetes, a new mutation in the mouse
    K P Hummel
    Science 153:1127-8. 1966
    b>Diabetes (db), which occurred in an inbred strain of mouse, is inherited as a unit autosomal recessive and is characterized by a metabolic disturbance resembling diabetes mellitus in man...
  6. pmc Leptin targets in the mouse brain
    Michael M Scott
    Division of Hypothalamic Research, Departments of Internal Medicine and Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Comp Neurol 514:518-32. 2009
    ..In the brain, leptin acts on numerous different cell types via the long-form leptin receptor (LepRb) to elicit its effects...
  7. pmc Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing
    Kazuichi Maruyama
    Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, USA
    Am J Pathol 170:1178-91. 2007
    Impaired wound healing is a common complication of diabetes. Although it is well known that both macrophages and blood vessels are critical to wound repair, the role of wound-associated lymphatic vessels has not been well investigated...
  8. pmc Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balance
    Gina M Leinninger
    Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Metab 14:313-23. 2011
    Leptin acts on leptin receptor (LepRb)-expressing neurons throughout the brain, but the roles for many populations of LepRb neurons in modulating energy balance and behavior remain unclear...
  9. pmc Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues
    H Fei
    Laboratory of Molecular Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 94:7001-5. 1997
    ..The obesity in GTG-treated mice is likely to be caused by ablation of Ob-Rb-expressing neurons, which results in leptin resistance...
  10. ncbi Identification of SOCS-3 as a potential mediator of central leptin resistance
    C Bjørbaek
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell 1:619-25. 1998
    ..A leptin-dependent increase of SOCS-3 mRNA was seen in areas of hypothalamus expressing high levels of the leptin receptor long form. In mammalian cell lines, SOCS-3, but not CIS or SOCS-2, blocked leptin-induced signal transduction...
  11. pmc Selective deletion of leptin receptor in neurons leads to obesity
    P Cohen
    Laboratory of Molecular Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    J Clin Invest 108:1113-21. 2001
    Animals with mutations in the leptin receptor (ObR) exhibit an obese phenotype that is indistinguishable from that of leptin deficient ob/ob mice...
  12. pmc The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways
    Dan Gao
    Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China
    J Biol Chem 285:29965-73. 2010
    ....
  13. ncbi GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress
    Bernardo Yusta
    Department of Medicine, Banting and Best Diabetes Centre, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Cell Metab 4:391-406. 2006
    ..We show that a murine model of diabetes is associated with the development of ER stress in beta cells and that treatment with the GLP-1R agonist exendin-..
  14. ncbi Identification and expression cloning of a leptin receptor, OB-R
    L A Tartaglia
    Millennium Pharmaceuticals, Incorporated, Cambridge, Massachusetts 02139, USA
    Cell 83:1263-71. 1995
    ..library was prepared from mouse choroid plexus and screened with a leptin-AP fusion protein to identify a leptin receptor (OB-R)...
  15. ncbi TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver
    Keyong Du
    Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037 1002, USA
    Science 300:1574-7. 2003
    Insulin resistance is a major hallmark in the development of type II diabetes, which is characterized by the failure of insulin to promote glucose uptake in muscle and to suppress glucose production in liver...
  16. pmc Defects in innate immunity predispose C57BL/6J-Leprdb/Leprdb mice to infection by Staphylococcus aureus
    Sunny Park
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Channing Laboratory, Boston, MA 02115, USA
    Infect Immun 77:1008-14. 2009
    ..hereafter, db/db) mice develop type 2 diabetes due to a recessive, autosomal mutation in the leptin receptor. We established a S...
  17. pmc Leptin does not directly affect CNS serotonin neurons to influence appetite
    Daniel D Lam
    Department of Pharmacology, University of Cambridge, UK
    Cell Metab 13:584-91. 2011
    ..Although some leptin receptor (LepRb) neurons lie close to 5-HT neurons in the dorsal raphe (DR), 5-HT neurons do not express LepRb...
  18. ncbi Angiotensin II type 1 receptor blockade improves beta-cell function and glucose tolerance in a mouse model of type 2 diabetes
    Kwan Yi Chu
    Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories
    Diabetes 55:367-74. 2006
    ..the hypothesis that there is a change in AT1R expression in the pancreatic islets of the obesity-induced type 2 diabetes model, the db/db mouse, which enables endogenous levels of angiotensin II to impair islet function...
  19. pmc The role of interstitial macrophages in nephropathy of type 2 diabetic db/db mice
    Volha Ninichuk
    Medizinische Poliklinik, Klinikum der Universitat Munchen Innenstadt, Pettenkoferstr 8a, 80336 Munchen, Germany
    Am J Pathol 170:1267-76. 2007
    ..These data identify oral treatment with the CCR1 antagonist BL5923 as a potential therapy for late-stage diabetic nephropathy...
  20. ncbi COX-2 up-regulation and vascular smooth muscle contractile hyperreactivity in spontaneous diabetic db/db mice
    Zhenheng Guo
    Department of Physiology, University of Kentucky, 509 Wethington Building, 900 South Limestone, Lexington, KY 40536, USA
    Cardiovasc Res 67:723-35. 2005
    Abnormalities in vascular constriction and dilatation are associated with early diabetes and contribute to diabetic vascular complications. However, mechanisms underlying such vascular dysfunction remain to be fully elucidated...
  21. pmc Complex regulation of mammalian target of rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional status
    Eneida C Villanueva
    Division of Metabolism, Department of Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Endocrinology 150:4541-51. 2009
    ..revealed the robust activation of mTORC1-dependent ARC pS6 in response to fasting and leptin deficiency in leptin receptor-expressing Agouti-related protein neurons...
  22. pmc Molecular mechanism by which pioglitazone preserves pancreatic beta-cells in obese diabetic mice: evidence for acute and chronic actions as a PPARgamma agonist
    Yukiko Kanda
    Diabetes and Endocrine Division, Kawasaki Medical School, Kurashiki, Japan
    Am J Physiol Endocrinol Metab 298:E278-86. 2010
    ....
  23. ncbi Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells
    Kenneth K Y Cheng
    Department of Medicine, University of Hong Kong, Hong Kong, China
    Diabetes 56:1387-94. 2007
    ..Taken together, these results suggest that APPL1 acts as a common downstream effector of AdipoR1 and -R2, mediating adiponectin-evoked endothelial NO production and endothelium-dependent vasodilation...
  24. ncbi Echocardiographic assessment of cardiac function in diabetic db/db and transgenic db/db-hGLUT4 mice
    Lisa M Semeniuk
    Department of Pharmacology and Therapeutics, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Am J Physiol Heart Circ Physiol 283:H976-82. 2002
    ..Cardiac function was normalized in transgenic db/db-hGLUT4 mice, indicating that altered cardiac metabolism can produce contractile dysfunction in diabetic db/db hearts...
  25. ncbi The influence of genetic background on the expression of mutations at the diabetes locus in the mouse IV. Male lethal syndrome in CBA/Lt mice
    E H Leiter
    Diabetes 30:1035-44. 1981
    ..A marked sexual dimorphism was observed in the diabetes syndrome in db/db animals...
  26. ncbi Development of hyperglycaemia and insulin resistance in conscious genetically diabetic (C57BL/KsJ-db/db) mice
    H Kodama
    Tsukuba Research Laboratories, Fujisawa Pharmaceutical Co Ltd, Ibaraki, Japan
    Diabetologia 37:739-44. 1994
    ..abstract truncated at 250 words)..
  27. ncbi The db/db mouse, a model for diabetic dyslipidemia: molecular characterization and effects of Western diet feeding
    K Kobayashi
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Metabolism 49:22-31. 2000
    Diabetic dyslipidemia is a major factor contributing to the accelerated atherosclerosis in type 2 diabetes mellitus...
  28. pmc Ventral tegmental area leptin receptor neurons specifically project to and regulate cocaine- and amphetamine-regulated transcript neurons of the extended central amygdala
    Rebecca L Leshan
    Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 30:5713-23. 2010
    Leptin acts via its receptor (LepRb) to regulate neural circuits in concert with body energy stores. In addition to acting on a number of hypothalamic structures, leptin modulates the mesolimbic dopamine (DA) system...
  29. pmc Direct innervation and modulation of orexin neurons by lateral hypothalamic LepRb neurons
    Gwendolyn W Louis
    Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, and Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 30:11278-87. 2010
    Leptin, the adipose-derived hormonal signal of body energy stores, acts via the leptin receptor (LepRb) on neurons in multiple brain regions...
  30. pmc Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons
    Jose Donato
    Department of Internal Medicine, Division of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9077, USA
    J Clin Invest 121:355-68. 2011
    ..Humans and mice lacking leptin or the leptin receptor (LepR) (ob/ob and db/db mice, respectively) are infertile and fail to enter puberty...
  31. pmc Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes
    Margaret Wu
    Department of Diabetes and Obesity, Merck Research Laboratories, Rahway, NJ 07065, USA
    Proc Natl Acad Sci U S A 108:5378-83. 2011
    ..PTM also reduced ambient glucose levels in db/db mice. These results provide pharmacological proof of concept of inhibiting fatty acid synthase for the treatment of diabetes and related metabolic disorders in animal models.
  32. pmc Central leptin signaling is required to normalize myocardial fatty acid oxidation rates in caloric-restricted ob/ob mice
    Crystal Sloan
    Program in Molecular Medicine, University of Utah, Salt Lake City, Utah, USA
    Diabetes 60:1424-34. 2011
    ..This study was designed to determine the contribution of central and peripheral leptin signaling to myocardial metabolism and function in ob/ob and db/db mice in the absence of diabetes and morbid obesity.
  33. ncbi Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor
    S C Chua
    Laboratory of Human Behavior and Metabolism, Rockefeller University, New York 10021, USA
    Science 271:994-6. 1996
    Mice harboring mutations in the obese (ob) and diabetes (db) genes display similar phenotypes, and it has been proposed that these genes encode the ligand and receptor, respectively, for a physiologic pathway that regulates body weight...
  34. ncbi Increased high density lipoprotein (HDL), defective hepatic catabolism of ApoA-I and ApoA-II, and decreased ApoA-I mRNA in ob/ob mice. Possible role of leptin in stimulation of HDL turnover
    D L Silver
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    J Biol Chem 274:4140-6. 1999
    ..Moreover, ob/ob neuropeptide Y-/- mice, despite marked attenuation of diabetes and obesity phenotypes, showed no change in HDL cholesterol levels relative to ob/ob mice...
  35. ncbi Activation of downstream signals by the long form of the leptin receptor
    A S Banks
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 275:14563-72. 2000
    ..adipocyte-derived hormone leptin signals the status of body energy stores by activating the long form of the leptin receptor (LRb)...
  36. ncbi Fatty acid metabolism is enhanced in type 2 diabetic hearts
    Andrew N Carley
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, Canada T2N 4N1
    Biochim Biophys Acta 1734:112-26. 2005
    The metabolic phenotype of hearts has been investigated using rodent models of type 2 diabetes which exhibit obesity and insulin resistance: db/db and ob/ob mice, and Zucker fatty and ZDF rats...
  37. ncbi Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis
    Sarah H Bates
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cell Metab 1:169-78. 2005
    Leptin activates the long form of the leptin receptor (LRb) to control feeding and neuroendocrine function and thus regulate adiposity...
  38. doi Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice
    Qiong Wang
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Chinese Academy of Sciences, The Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Hepatology 49:1166-75. 2009
    ..We found that in leptin receptor-deficient db/db mice, the expression of ACL was selectively elevated in the liver but not in the white ..
  39. pmc Direct innervation of GnRH neurons by metabolic- and sexual odorant-sensing leptin receptor neurons in the hypothalamic ventral premammillary nucleus
    Rebecca L Leshan
    Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 29:3138-47. 2009
    Leptin acts via its receptor (LepRb) on specific CNS neurons to signal the adequacy of long-term energy stores, thereby permitting the expenditure of resources on energy-intensive processes such as reproduction...
  40. ncbi Regulation of Jak kinases by intracellular leptin receptor sequences
    Carolyn Kloek
    Section on Obesity, Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 277:41547-55. 2002
    Leptin signals the status of body energy stores via the leptin receptor (LR), a member of the Type I cytokine receptor family...
  41. ncbi LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin
    Sarah H Bates
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 53:3067-73. 2004
    ..tissue communicates body energy status to the neuroendocrine system by activating the long form of the leptin receptor (LRb)...
  42. ncbi Diabetic neuropathy in the mutant mouse [C57BL/ks(db/db)]: a morphometric study
    D M Robertson
    Diabetes 29:60-7. 1980
    ..Morphometric changes occurred first after 20 wk of diabetes in both myelinated and unmyelinated fibers...
  43. pmc Glycemic improvement in diabetic db/db mice by overexpression of the human insulin-regulatable glucose transporter (GLUT4)
    E M Gibbs
    Department of Metabolic Diseases, Pfizer, Inc, Groton, Connecticut 06340, USA
    J Clin Invest 95:1512-8. 1995
    ..muscle/fat glucose transporter) expression on glucose homeostasis in a genetic model of non-insulin-dependent diabetes mellitus were determined by expressing a human GLUT4 transgene (hGLUT4) in diabetic C57BL/KsJ-db/db mice...
  44. doi Involvement of TNF-alpha in abnormal adipocyte and muscle sortilin expression in obese mice and humans
    V Kaddai
    INSERM U895, Mediterranean Center of Molecular Medicine C3M, Bâtiment Archimed, Nice Cedex 3, France
    Diabetologia 52:932-40. 2009
    ..Our goal was to determine whether proteins controlling GLUT4 trafficking are altered in insulin resistance linked to obesity...
  45. pmc Diabetes and insulin in regulation of brain cholesterol metabolism
    Ryo Suzuki
    Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Cell Metab 12:567-79. 2010
    ..Thus, insulin and diabetes can alter brain cholesterol metabolism, and this may play an important role in the neurologic and metabolic ..
  46. ncbi Down-regulation of the expression of the obese gene by an antidiabetic thiazolidinedione in Zucker diabetic fatty rats and db/db mice
    B Zhang
    Department of Molecular Endocrinology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Biol Chem 271:9455-9. 1996
    ..db/db mice, decreased the expression of the ob gene in these animal models of obesity and non-insulin-dependent diabetes mellitus...
  47. ncbi Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling
    Hang Shi
    Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    J Biol Chem 279:34733-40. 2004
    ..We conclude that SOCS3 plays an important role in mediating insulin resistance and may be an excellent target for therapeutic intervention in insulin resistance and type II diabetes.
  48. ncbi An allelic series for the leptin receptor gene generated by CRE and FLP recombinase
    Julie E McMinn
    Department of Pediatrics, Division of Molecular Genetics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Mamm Genome 15:677-85. 2004
    ..Lepr(db/db) mice are obese due to a defect in the signaling portion of the leptin receptor, which has led to extensive study of this highly conserved system over the past several years...
  49. ncbi Oxidative damage in cerebral vessels of diabetic db/db mice
    Y J Liao
    Department of Physiology, Faculty of Basic Medicine, China Medical University, Shenyang, PR China
    Diabetes Metab Res Rev 21:554-9. 2005
    Oxidative stress in diabetes mellitus has recently received increasing attention as it has been proven to be associated with the development of diabetic vascular complications...
  50. doi Activating transcription factor 3 constitutes a negative feedback mechanism that attenuates saturated Fatty acid/toll-like receptor 4 signaling and macrophage activation in obese adipose tissue
    Takayoshi Suganami
    Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, Japan
    Circ Res 105:25-32. 2009
    ..Our data also suggest that activation of ATF3 in macrophages offers a novel therapeutic strategy to prevent or treat obesity-induced adipose tissue inflammation...
  51. pmc Mammary ductal growth is impaired in mice lacking leptin-dependent signal transducer and activator of transcription 3 signaling
    Stephanie R Thorn
    Department of Animal Science, Cornell University, Ithaca, New York 14853, USA
    Endocrinology 151:3985-95. 2010
    ..These data imply the existence of an unknown mechanism whereby leptin-dependent STAT3 signaling and obesity alter mammary ductal development...
  52. pmc Nociceptin/orphanin FQ suppresses the excitability of neurons in the ventromedial nucleus of the hypothalamus
    Melissa J Chee
    Centre for Neuroscience, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    J Physiol 589:3103-14. 2011
    ..of N/OFQ were studied using whole cell patch-clamp recordings from VMN neurons expressing the anorexigenic leptin receptor (LepRb)...
  53. pmc A new class of obesity genes encodes leukocyte adhesion receptors
    Z M Dong
    Center for Blood Research, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 94:7526-30. 1997
    ..Our results indicate that (i) leukocytes play a role in preventing excess body fat deposition and (ii) defects in leukocyte adhesion receptors can result in obesity...
  54. ncbi A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
    K Clement
    Laboratoire de Nutrition et Service de Médecine et Nutrition, Hôtel Dieu place du Parvis Notre Dame, Paris, France
    Nature 392:398-401. 1998
    ..Leptin acts through the leptin receptor, a single-transmembrane-domain receptor of the cytokine-receptor family...
  55. ncbi Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
    G M Lord
    Imperial College School of Medicine, Department of Immunology, The Hammersmith Hospital, London, UK
    Nature 394:897-901. 1998
    ..Our findings suggest a new role for leptin in linking nutritional status to cognate cellular immune function, and provide a molecular mechanism to account for the immune dysfunction observed in starvation...
  56. ncbi Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents
    X L Li
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University 60, 812 8582, Fukuoka, Japan
    Neuroscience 113:607-15. 2002
    ..long-term potentiation (LTP) and long-term depression (LTD), and the spatial-memory function in two leptin receptor-deficient rodents (Zucker rats and db/db mice)...
  57. ncbi The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms
    Yusong Gong
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 282:31019-27. 2007
    The action of leptin via the long form of its receptor (LepRb) is central to the control of body energy homeostasis and neuroendocrine function, but the mechanisms by which LepRb regulates intracellular signaling have remained ..
  58. ncbi Enhanced gustatory neural responses to sugars in the diabetic db/db mouse
    Y Ninomiya
    Department of Oral Physiology, Asahi University School of Dentistry, Gifu, Japan
    Am J Physiol 269:R930-7. 1995
    Sweet taste sensitivity in a genetic model of diabetes, the db/db mouse, in which a single major gene defect leads to the expression of diabetes and obesity, was studied by examining chorda tympani nerve responses to various taste stimuli,..
  59. ncbi LPS-induced anorexia in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice
    R Faggioni
    Department of Medicine, University of California, USA
    Am J Physiol 273:R181-6. 1997
    ..To further investigate the role of leptin in the LPS-induced anorexia, we administered LPS to leptin receptor-deficient (db/db) and leptin-deficient (ob/ob) mice...
  60. ncbi Leptin regulates proinflammatory immune responses
    S Loffreda
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
    FASEB J 12:57-65. 1998
    Obesity is associated with an increased incidence of infection, diabetes, and cardiovascular disease, which together account for most obesity-related morbidity and mortality...
  61. pmc Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice
    J Seufert
    The Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 96:674-9. 1999
    ..Thus leptin exerts inhibitory effects on both insulin secretion and insulin gene expression in pancreatic beta-cells, but by different cellular mechanisms...
  62. ncbi SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985
    C Bjorbak
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, and Section on Obesity, Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    J Biol Chem 275:40649-57. 2000
    During leptin signaling, each of the phosphorylated tyrosine residues on the long form of the leptin receptor (LRb) mediates distinct signals...
  63. ncbi Color subtractive-computer-assisted image analysis for quantification of cutaneous nerves in a diabetic mouse model
    R A Underwood
    Department of Medicine Dermatology, University of Washington, Seattle, Washington, USA
    J Histochem Cytochem 49:1285-91. 2001
    ..Using CS-CAIA, epidermal nerve profile counts, area fraction, and area density were significantly lower in db/db compared to db/- mice...
  64. ncbi Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin
    Kamal Rahmouni
    Hypertension Genetics Specialized Center of Research, and Department of Internal Medicine, University of Iowa and the Veterans Administration Medical Center, Iowa City, Iowa 52242, USA
    J Neurosci 23:5998-6004. 2003
    ..of leptin, insulin, MC-3/4R agonist (MTII), and corticotrophin-releasing factor (CRF) on RSNA in leptin receptor-deficient (db/db) mice, MC-4R knock-out mice, and their wild-type controls...
  65. ncbi Leptin modulates behavioral responses to sweet substances by influencing peripheral taste structures
    Noriatsu Shigemura
    Section of Oral Neuroscience, Graduate School of Dental Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Endocrinology 145:839-47. 2004
    Leptin is a hormone that regulates body weight homeostasis mainly via the hypothalamic functional leptin receptor Ob-Rb. Recently, we proposed that the taste organ is a new peripheral target for leptin...
  66. ncbi Low levels of expression of leptin receptor at the cell surface result from constitutive endocytosis and intracellular retention in the biosynthetic pathway
    Sandrine Belouzard
    Unité Propre de Recherche 2511, Institut de Biologie de Lille, CNRS, 59021 Lille, France
    J Biol Chem 279:28499-508. 2004
    The leptin receptor is mainly localized in intracellular compartments in target tissues...
  67. ncbi Obese and diabetic db/db mice develop marked liver fibrosis in a model of nonalcoholic steatohepatitis: role of short-form leptin receptors and osteopontin
    Atul Sahai
    Department of Pediatrics, The Feinberg School of Medicine, Northwestern University, Children s Memorial Institute for Education and Research, Chicago, IL 60614, USA
    Am J Physiol Gastrointest Liver Physiol 287:G1035-43. 2004
    Obesity and type 2 diabetes are associated with nonalcoholic steatohepatitis (NASH), but an obese/diabetic animal model that mimics human NASH remains undefined...
  68. ncbi Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3
    Sarah L Dunn
    Division of Metabolism, Endocrinology and Diabetes, Department of Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0638, USA
    Mol Endocrinol 19:925-38. 2005
    ..Using cultured cells exogenously expressing the long form of the leptin receptor (LRb) or an erythropoietin receptor/LRb chimera, we show that chronic stimulation results in the attenuation ..
  69. ncbi Increased glucocorticoid receptor and 11{beta}-hydroxysteroid dehydrogenase type 1 expression in hepatocytes may contribute to the phenotype of type 2 diabetes in db/db mice
    Yanjun Liu
    Charles R Drew University of Medicine and Sciences, Division of Endocrinology, UCLA School of Medicine, 1731 E 120th St, Los Angeles, CA 90059, USA
    Diabetes 54:32-40. 2005
    ..tissue glucocorticoid action may contribute to the hyperglycemia and insulin resistance associated with type 2 diabetes, but the associated mechanisms are poorly understood...
  70. ncbi Myocardial infarction and heart failure in the db/db diabetic mouse
    James J M Greer
    Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, USA
    Am J Physiol Heart Circ Physiol 290:H146-53. 2006
    ..These studies provide a feasible experimental model system for the investigation of heart failure secondary to acute myocardial infarction in the db/db diabetic mouse...
  71. ncbi Enhanced proatherogenic responses in macrophages and vascular smooth muscle cells derived from diabetic db/db mice
    Shu Lian Li
    Department of Diabetes, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA
    Diabetes 55:2611-9. 2006
    b>Diabetes is associated with enhanced inflammatory responses and cardiovascular complications such as atherosclerosis...
  72. ncbi Appropriate inhibition of orexigenic hypothalamic arcuate nucleus neurons independently of leptin receptor/STAT3 signaling
    Heike Munzberg
    Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 27:69-74. 2007
    ..CFLIR) as a marker of ARC neuronal activity in db/db mice devoid of the signaling form of the leptin receptor (LRb) and s/s mice that express LRb(S1138) [which is defective for STAT3 (signal transducer and activator of ..
  73. pmc Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function
    Marie Björnholm
    Departments of Internal Medicine and Molecular and Integrative Physiology, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
    J Clin Invest 117:1354-60. 2007
    ..Thus, leptin activates autoinhibitory signals via LRb Tyr985 to attenuate the anti-adiposity effects of leptin, especially in females, potentially contributing to leptin insensitivity in obesity...
  74. ncbi SH2B1 enhances leptin signaling by both Janus kinase 2 Tyr813 phosphorylation-dependent and -independent mechanisms
    Zhiqin Li
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0622, USA
    Mol Endocrinol 21:2270-81. 2007
    Leptin controls body weight by activating its long form receptor (LEPRb). LEPRb binds to Janus kinase 2 (JAK2), a cytoplasmic tyrosine kinase that mediates leptin signaling...
  75. ncbi PTEN expression contributes to the regulation of muscle protein degradation in diabetes
    Zhaoyong Hu
    Baylor College of Medicine, Nephrology Division, M S BCM 285, One Baylor Plaza, Alkek N 520, Houston, TX 77030, USA
    Diabetes 56:2449-56. 2007
    ..We evaluated the control of muscle protein synthesis and degradation in mouse models of type 1 and 2 diabetes to determine whether defects besides PI3K/Akt activities affect muscle metabolism.
  76. pmc Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice
    Tomoaki Morioka
    Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA
    J Clin Invest 117:2860-8. 2007
    ..disrupting leptin signaling in the pancreas on beta cell growth and/or function, we created pancreas-specific leptin receptor (ObR) KOs using mice expressing Cre recombinase under the control of the pancreatic and duodenal homeobox 1 (..
  77. pmc FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice
    Adama Kamagate
    Rangos Research Center, Children s Hospital of Pittsburgh, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Clin Invest 118:2347-64. 2008
    ..These data suggest that FoxO1 mediates insulin regulation of MTP production and that augmented MTP levels may be a causative factor for VLDL overproduction and hypertriglyceridemia in diabetes.
  78. ncbi Impairment of cell-mediated immunity in mutation diabetic mice (db/db)
    M A Mandel
    J Immunol 120:1375-7. 1978
    Mutation diabetes in the mouse occurs in the C57BL/Ks strain. All homozygous animals (db/db) develop obesity, elevated blood sugar levels and increased or normal blood insulin concentration...
  79. ncbi Obesity genes: beneficial effects in heterozygous mice
    D L Coleman
    Science 203:663-5. 1979
    The mouse mutant genes obese (ob) and diabetes (db) cause similar obesity-diabetes states in homozygotes...
  80. ncbi Weight-reducing effects of the plasma protein encoded by the obese gene
    J L Halaas
    Laboratory of Molecular Genetics, Howard Hughes Medical Institute, Rockfeller University, New York, NY 10021, USA
    Science 269:543-6. 1995
    ..2 to 0.7 percent. These data suggest that the OB protein serves an endocrine function to regulate body fat stores...
  81. ncbi PDGF and TGF-alpha act synergistically to improve wound healing in the genetically diabetic mouse
    R L Brown
    Shriners Burns Institute, Cincinnati, Ohio 45229
    J Surg Res 56:562-70. 1994
    ..The PDGF-BB/TGF-alpha combination accelerated healing in the diabetic animals to a rate that was closer to that seen in nondiabetic mice.(ABSTRACT TRUNCATED AT 250 WORDS)..
  82. ncbi Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice
    H Chen
    Millennium Pharmaceuticals, Incorporated, Cambridge, Massachusetts 02139, USA
    Cell 84:491-5. 1996
    ....
  83. ncbi Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice
    C Vaisse
    Laboratory of Metabolic Diseases, Rockefeller University, New York, New York 10021, USA
    Nat Genet 14:95-7. 1996
    ..Leptin's precise sites of action are not known. The leptin receptor (Ob-R) is found in many tissues in several alternatively spliced forms raising the possibility that leptin ..
  84. ncbi NIDDM genes in mice: deleterious synergism by both parental genomes contributes to diabetogenic thresholds
    E H Leiter
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Diabetes 47:1287-95. 1998
    ..both cross directions identified an NON-derived diabetogenic locus, Nidd 1, on chromosome (Chr) 4 near the leptin receptor. This locus was associated with reduced plasma insulin, increased non-fasted blood glucose, and lower body ..
  85. ncbi Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass
    P Ducy
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 100:197-207. 2000
    ..To test this hypothesis, we studied leptin-deficient and leptin receptor-deficient mice that are obese and hypogonadic...
  86. ncbi Leptin-regulated endocannabinoids are involved in maintaining food intake
    V Di Marzo
    Endocannabinoid Research Group, Istituto per la Chimica di Molecole di Interesse Biologico, CNR, 80072, Arco Felice, Naples, Italy
    Nature 410:822-5. 2001
    ..These findings indicate that endocannabinoids in the hypothalamus may tonically activate CB1 receptors to maintain food intake and form part of the neural circuitry regulated by leptin...
  87. ncbi STAT3 signalling is required for leptin regulation of energy balance but not reproduction
    Sarah H Bates
    Research Division, Joslin Diabetes Center, Harvard Medical School, 1 Joslin Place, Boston, Massachusetts 02215, USA
    Nature 421:856-9. 2003
    Secretion of leptin from adipocytes communicates body energy status to the brain by activating the leptin receptor long form (LRb)...
  88. ncbi Diabetic kidney disease in the db/db mouse
    Kumar Sharma
    Dorrance Hamilton Research Laboratory, Division of Nephrology, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Am J Physiol Renal Physiol 284:F1138-44. 2003
    ..A large number of mouse models of diabetes have been identified and their kidney disease characterized to various degrees...
  89. ncbi Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice
    Lili A Barouch
    Department of Medicine, Division of Cardiology, Johns Hopkins Hospital, 600 North Wolfe St, Baltimore, MD 21287, USA
    Circulation 108:754-9. 2003
    ..Because leptin has cardiovascular bioactivity, we hypothesized that disruption of leptin signaling mediates the development of obesity-associated LVH...
  90. pmc Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism
    Eric E Zhang
    Program in Signal Transduction, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 101:16064-9. 2004
    ..is to control energy balance and metabolism, and that this phosphatase is a critical signaling component of leptin receptor ObRb in the hypothalamus...
  91. ncbi Endothelial dysfunction in Type 2 diabetes correlates with deregulated expression of the tail-anchored membrane protein SLMAP
    Hong Ding
    School of Medical Sciences, RMIT Univ, Bundoora West Campus, Bundoora, Victoria 3083, Australia
    Am J Physiol Heart Circ Physiol 289:H206-11. 2005
    ..Thus changes in SLMAP expression may be an important indicator for microvascular disease associated with Type 2 diabetes.
  92. ncbi IL-1beta-mediated innate immunity is amplified in the db/db mouse model of type 2 diabetes
    Jason C O'Connor
    Department of Animal Sciences, University of Illinois at Urbana Champain, Urbana, IL 61801, USA
    J Immunol 174:4991-7. 2005
    Chronic inflammation appears to play a critical role in type 2 diabetes and its complications. Here we tested the hypothesis that this inflammatory dysregulation affects the IL-1beta system and has functional consequences in the brain...
  93. pmc Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice
    Aimin Xu
    Department of Medicine, Research Center of Heart, Brain, Hormone, and Healthy Aging, and Genome Research Center, University of Hong Kong, Hong Kong, China
    Proc Natl Acad Sci U S A 102:6086-91. 2005
    ..In patients with type 2 diabetes, serum levels of ANGPTL4 were significantly lower than those in healthy subjects, suggesting that the decreased ..
  94. ncbi Increased expression of NAD(P)H oxidase in islets of animal models of Type 2 diabetes and its improvement by an AT1 receptor antagonist
    Mieko Nakayama
    Department of Medicine and Bioregulatory Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 332:927-33. 2005
    This study was undertaken to reveal the role of NAD(P)H oxidase in increased oxidative stress in islets of Type 2 diabetes. Immunostaining analysis showed that staining intensities of NAD(P)H oxidase components, gp91phox and p22phox, ..
  95. ncbi Type 2 diabetic mice have increased arteriolar tone and blood pressure: enhanced release of COX-2-derived constrictor prostaglandins
    Zsolt Bagi
    Division of Physiology, New York Medical College, Valhalla, NY, USA
    Arterioscler Thromb Vasc Biol 25:1610-6. 2005
    Type 2 diabetes mellitus (T2-DM) is frequently associated with vascular dysfunction and elevated blood pressure, yet the underlying mechanisms are not completely understood...
  96. ncbi The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity
    Roberto Coppari
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
    Cell Metab 1:63-72. 2005
    ..physiological significance of leptin signaling in the ARH, we used mice homozygous for a FLPe-reactivatable, leptin receptor null allele (Lepr(neo/neo) mice)...
  97. pmc Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes
    Carl De Luca
    Department of Medicine, Division of Preventative Medicine, Columbia University, New York, New York, USA
    J Clin Invest 115:3484-93. 2005
    We have generated mice that carry a neuron-specific leptin receptor (LEPR) transgene whose expression is driven by the rat synapsin I promoter synapsin-LEPR B (SYN-LEPR-B)...
  98. ncbi TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes
    Yoshimi Nakagawa
    Department of Internal Medicine, Metabolism and Endocrinology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki, Japan, 305 8575
    Nat Med 12:107-13. 2006
    ..Collectively, plasma glucose levels were markedly reduced both in normal mice and in different mouse models of diabetes, including streptozotocin-treated, db/db and KK mice...
  99. ncbi Tmem27: a cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation
    Pinar Akpinar
    Laboratory of Metabolic Diseases, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Cell Metab 2:385-97. 2005
    ..Our results identify a pancreatic beta cell transmembrane protein that regulates cell growth of pancreatic islets...
  100. pmc Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice
    Yanqiao Zhang
    Department of Biological Chemistry, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 103:1006-11. 2006
    ..In view of its central roles in coordinating regulation of both glucose and lipid metabolism, we propose that FXR agonists are promising therapeutic agents for treatment of diabetes mellitus.
  101. ncbi Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis
    Harveen Dhillon
    Department of Medicine, Division of Endocrinology, Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
    Neuron 49:191-203. 2006
    ..These results reveal a critical role for leptin action on VMH neurons...

Research Grants44

  1. New Insights into Animals Models of Diabetes
    Edward Leiter; Fiscal Year: 2003
    ..of laboratory animals to gain better understanding of the etiology, pathophysiology, and treatment of Type 1 Diabetes (T1D), Type 2 Diabetes (T2D), and the complications common to both...
  2. Regulation of Pulmonary Host Defense by Leptin
    Peter Mancuso; Fiscal Year: 2010
    ..pneumoniae challenge by blocking leptin receptor signaling in vivo using a pharmacologic antagonist and leptin receptor transgenic mice;2) Determine the ..
  3. NEW MOUSE MODELS OF DIABESITY
    Edward Leiter; Fiscal Year: 2002
    ..models that more accurately reflect the pathophysiology underlying the most commonly occurring forms of type II diabetes (NIDDM) in humans...
  4. PATHOGENESIS OF AUTOIMMUNE DIABETES IN MICE
    Edward Leiter; Fiscal Year: 2004
    The immunopathogenetic events underlying the development of Type 1 diabetes (TiD) in the NOD mouse have been the focus of this grant since its inception...
  5. GENETICS AND PATHOLOGY OF NON-OBESE DIABETIC (NOD) MICE
    Edward Leiter; Fiscal Year: 2005
    ..of this grant is to use genetics to define mechanisms underlying immunopathogenesis of insulin dependent diabetes mellitus (Type 1 Diabetes, T1D) in the NOD mouse...
  6. Leptin Signaling in Cardiac Hypertrophy
    LILI BAROUCH; Fiscal Year: 2008
    ..Barouch will launch a successful career as an independent physician-scientist. ..
  7. Generation of Collecting Duct Knockout of PPARgamma
    Tianxin Yang; Fiscal Year: 2006
    ..synthetic insulin sensitizing thiazolidinedione compounds (TZD), are highly effective in treatment of type II diabetes. However, these drugs are associated with fluid retention, representing early evidence for involvement of ..
  8. Functional aspects of SREBP1c in intact skeletal muscle
    Paul MacLean; Fiscal Year: 2007
    ....
  9. Transport of neurotrophic cytokines after spinal cord injury
    Weihong Pan; Fiscal Year: 2007
    ..Understanding the mechanisms of cytokine transport at this regulatory interface would help in the design of new approaches to treat SCI. ..
  10. Central Serotonergic Pathways Regulating Energy Balance
    LORA HEISLER; Fiscal Year: 2007
    ..the basic neurobiology of energy homeostasis is paramount in the prevention and treatment of obesity and type II diabetes. Drugs that increase the activity of central serotonin (5-hydroxytryptamine, 5-HT) have been widely used as ..
  11. International Network and Registry for TMA
    Howard Trachtman; Fiscal Year: 2007
    ..These include essential hypertension, diabetes, hyperlipidemia, myocardial infarction, and chronic kidney disease. [unreadable] [unreadable]
  12. REGULATION OF ADIPOCYTE PROTEIN SYNTHESIS BY AMINO ACIDS
    Christopher Lynch; Fiscal Year: 2007
    ..The proposed studies will elucidate how leucine regulates mTOR and the roles of leucine stimulation of mTOR in adipose tissue physiology and obesity. ..
  13. Transport of TNFalpha across the BBB
    Weihong Pan; Fiscal Year: 2008
    ..These transporters could be novel drug targets and therefore provide promising therapeutic potential. [unreadable] [unreadable]..
  14. Interaction of COX-2 AND nNOS in renin secretion (R01)
    Tianxin Yang; Fiscal Year: 2008
    ..abstract_text> ..
  15. Renal medullary COX-2 in blood pressure control
    Tianxin Yang; Fiscal Year: 2008
    ..The information resulted from these studies will provide new insight into the molecular mechanism responsible for long-term control of arterial blood pressure. ..
  16. New Mechanisms in the Pathogenesis of Diabetic Nephropathy
    Rama Natarajan; Fiscal Year: 2008
    unreadable] DESCRIPTION (provided by applicant): Diabetic nephropathy (DN) is one of the major complications of diabetes. It accounts for almost half of all patients with end stage renal disease needing dialysis and is therefore a major ..
  17. Interaction of COX-2 and nNOS in renin secretion
    Tianxin Yang; Fiscal Year: 2006
    ....
  18. Mesenchymal cells in surgical wound healing
    Nicole Gibran; Fiscal Year: 2008
    ..3. To determine whether bone marrow-derived MSC can reverse diabetes impaired wound healing. 4. To determine whether bone marrow-derived MSC are critical for wound healing...
  19. The Role of 11beta-HSD1 in Type II Diabetes and Obesity
    Yanjun Liu; Fiscal Year: 2008
    ..Similarly, we used an animal model of type 2 diabetes, called obese db/db mice and found that they have high liver and fat levels of 11 beta -HSD1, which positively ..
  20. Low-cost, portable, computer assisted imaging for diabe*
    Michael Abramoff; Fiscal Year: 2008
    ..Our overall aim is to validate and optimize a low-cost, high quality, patient friendly imaging system for the early diagnosis of diabetic retinopathy. ..
  21. Foxo1 in Triglyceride Metabolism
    Hengjiang Henry Dong; Fiscal Year: 2010
    Hypertriglyceridemia is the commonest lipid disorder associated with insulin resistance and type 2 diabetes. It is characterized by increased production and decreased clearance of triglyceride (TG)-rich very low-density lipoproteins (VLDL)..
  22. EXPERIMENTAL DIABETIC AUTONOMIC NEUROPATHY
    ROBERT EDWARD SCHMIDT; Fiscal Year: 2010
    ..established ganglionic NAD resulted in nearly complete reversal of NAD without altering the metabolic severity of diabetes, suggesting a role for IGF-I in its pathogenesis and therapy...
  23. Role of Leucine Metabolism in Leucine Signaling
    CHRISTOPHER JOHN LYNCH; Fiscal Year: 2010
    ..The implication of our ongoing research is that blocking the first step in BCAA metabolism with a drug, or to a less extent increasing dietary BCAAs, will promote weight loss. ..
  24. Surgical Wound Repair: Role of A Neuroendothelial Axis
    NICOLE SIMONE GIBRAN; Fiscal Year: 2010
    ..The scars have hypervascularity and increased innervation. In contrast, non-healing ulcers of diabetes mellitus have microangiopathy and decreased innervation...
  25. Conference on Obesity
    Rudolph Leibel; Fiscal Year: 2004
    ..Obesity accounts for major fractions of type 2 diabetes, dyslipidemias, hypertension and stroke, and a growing proportion of certain cancers...
  26. CELL GROWTH, NA/H EXCHANGE, AND CYCLINS IN IDDM PATIEN
    Daniel Batlle; Fiscal Year: 2002
    ....
  27. NEUROTROPHIN 3 IN NEURONAL INJURY AND DISEASE
    Douglas Wright; Fiscal Year: 2002
    ..Results from these studies will define new biological actions of NT-3 and reveal how manipulation of the trophic support of neurons may be useful to treat pathologic neural conditions. ..
  28. Local Angiogenic Gene Therapy/VEGF/Treat Diabetic Ulcers
    Harold Brem; Fiscal Year: 2003
    ..In addition, we will analyze the wound fluid in order to determine the temporal expression of VEGF in a diabetic ulcer. ..
  29. FLOW SHEAR INDUCED NF-KB MEDIATED REGULATION
    Sumathy Mohan; Fiscal Year: 2003
    ..Understanding of NF- kappaB signaling mechanisms in VCAM-1 regulation can also be applied to other inflammatory conditions. ..
  30. Determinants of Tolerance to Nitrous Oxide Hypothermia
    Karl Kaiyala; Fiscal Year: 2004
    ..These studies have theoretical importance for understanding the mechanisms of drug tolerance and will begin to suggest the physiological basis of individual differences in vulnerability to addiction and drug abuse. ..
  31. Human monoclonal antibody therapy for HUS
    Howard Trachtman; Fiscal Year: 2004
    ..abstract_text> ..
  32. The role of Gq in insulin resistant cardiac hypertrophy
    Patrick Yue; Fiscal Year: 2006
    ..Specific Aim 3: To study the effect of Gq ablation on the MAPK signaling cascade, a major pathway leading to hypertrophy. ..
  33. Cellular Basis for Non-Parallel Gonadotropin Release
    Gwen Childs; Fiscal Year: 2005
    ..An understanding of mechanisms that selectively regulate gene expression in these cells will provide important information about how fertility is regulated. ..
  34. Gene Therapy of Muscle Wasting From Uremia
    Xiaonan Wang; Fiscal Year: 2005
    ..We believe that the experimental results will shed the insight on the mechanisms of muscle protein degradation, and provide a possible new approach to treat the pathological process of muscle wasting. ..
  35. ODORANT-RECEPTOR INTERACTIONS IN OLFACTORY NEURONS
    Thomas Getchell; Fiscal Year: 2005
    ..Understanding the signaling regulating neurogenesis in the OE will yield insights into mechanisms for restoring olfactory function compromised by aging, trauma, and neurodegenerative diseases. ..
  36. Local Angiogenic Therapy for Diabetic Ulcers
    Harold Brem; Fiscal Year: 2006
    ..to develop, coordinate and translate laboratory findings on gene therapy, growth factors, angiogenesis, and diabetes into practical clinical applications for developing new local angiogenic gene therapy for treatment of diabetic ..
  37. NEUROPATHOLOGY OF THE AGING SYMPATHETIC NERVOUS SYSTEM
    Robert Schmidt; Fiscal Year: 2006
    ..The results of these experiments should provide insight not only into autonomic dysfunction, but into a variety of pathologic processes in which NAD is a prominent component. ..
  38. Diabetic Neuropathy: Implications for Wound Repair
    Nicole Gibran; Fiscal Year: 2006
    ..In contrast, non-healing chronic ulcers associated with diabetes mellitus are characterized by microangiopathy and decreased innervations...
  39. Regulation of Leptin Production by Gonadotropes
    Gwen Childs; Fiscal Year: 2005
    ..These feasibility studies will thus provide information that will allow us to design future experiments for full funding. ..
  40. MULTICENTER TRIAL OF SYNSORB PK IN E COLI RELATED HUS
    Howard Trachtman; Fiscal Year: 2003
    ..The outcome of this trial may justify the use of SYNSORB PK as a safe therapy to ameliorate D+HUS. ..
  41. Novel Therapies for Resistant FSGS
    Howard Trachtman; Fiscal Year: 2006
    ..The infrastructure that is established for the performance of this R21/R33 project should prove useful for the efficient assessment of additional novel therapies that will be developed in the future for patients with primary FSGS. ..
  42. Neuroadaptive Substrates for Nitrous Oxide Tolerance
    Karl Kaiyala; Fiscal Year: 2006
    ..This work will be the first to identify brain areas activated by a drug-induced hypothermic stimulus and its adaptive consequences. These studies have theoretical importance for understanding and treating drug addiction. ..
  43. ENERGY HOMEOSTASIS IN HUMAN OBESITY
    Rudolph Leibel; Fiscal Year: 2001
    ..Hypertension, stroke, diabetes and disordered blood lipids have been clearly related to obesity...