Lcat

Summary

Gene Symbol: Lcat
Description: lecithin cholesterol acyltransferase
Alias: AI046659, D8Wsu61e, phosphatidylcholine-sterol acyltransferase, lecithin-cholesterol acyltransferase Lcat, phospholipid-cholesterol acyltransferase
Species: mouse

Top Publications

  1. doi Lack of LCAT reduces the LPS-neutralizing capacity of HDL and enhances LPS-induced inflammation in mice
    Peristera Ioanna Petropoulou
    Pharmacology Department, University of Patras Medical School, Rio Achaias TK 26500, Greece
    Biochim Biophys Acta 1852:2106-15. 2015
  2. pmc Increased plasma cholesterol esterification by LCAT reduces diet-induced atherosclerosis in SR-BI knockout mice
    Seth G Thacker
    Lipoprotein Metabolism Section, Cardiovascular Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
    J Lipid Res 56:1282-95. 2015
  3. doi The Effect of Natural LCAT Mutations on the Biogenesis of HDL
    Panagiotis Fotakis
    Molecular Genetics, Boston University School of Medicine, 700 Albany Street, W509, Boston, Massachusetts 02118 2394, United States
    Biochemistry 54:3348-59. 2015
  4. pmc Tissue- and sex-specific effects of β-carotene 15,15' oxygenase (BCO1) on retinoid and lipid metabolism in adult and developing mice
    Youn Kyung Kim
    Department of Food Science and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08091, USA
    Arch Biochem Biophys 572:11-8. 2015
  5. pmc Loss of β-carotene 15,15'-oxygenase in developing mouse tissues alters esterification of retinol, cholesterol and diacylglycerols
    Joseph L Dixon
    Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ 08901, USA Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08901, USA
    Biochim Biophys Acta 1841:34-43. 2014
  6. doi DYRK1A overexpression decreases plasma lecithin:cholesterol acyltransferase activity and apolipoprotein A-I levels
    Asma Tlili
    Universite Paris Diderot, Sorbonne Paris Cité, Unit of Functional and Adaptive Biology BFA, EAC CNRS 4413, Case 7104, 75205 Paris Cedex 13, France
    Mol Genet Metab 110:371-7. 2013
  7. pmc Cellular pregnenolone esterification by acyl-CoA:cholesterol acyltransferase
    Maximillian A Rogers
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Biol Chem 287:17483-92. 2012
  8. doi The role of lecithin:cholesterol acyltransferase in the modulation of cardiometabolic risks - a clinical update and emerging insights from animal models
    Dominic S Ng
    Keenan Research Center, Li Ka Shing Knowledge Institute, St Michael s Hospital, Canada
    Biochim Biophys Acta 1821:654-9. 2012
  9. pmc Regulation of plasma cholesterol esterification by sphingomyelin: effect of physiological variations of plasma sphingomyelin on lecithin-cholesterol acyltransferase activity
    Papasani Venkata Subbaiah
    Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Biochim Biophys Acta 1821:908-13. 2012
  10. pmc Lecithin:cholesterol acyltransferase deficiency protects against cholesterol-induced hepatic endoplasmic reticulum stress in mice
    Lauren Hager
    Keenan Research Centre, Li Ka Shing Knowledge Institute, Department of Medicine, St Michael s Hospital, Toronto M5B 1W8, Canada
    J Biol Chem 287:20755-68. 2012

Research Grants

  1. LCAT AND PATHOPHYSIOLOGY OF PHOSPHOLIPID SPECIES
    Papasani Subbaiah; Fiscal Year: 2002
  2. ROLE OF SPHINGOMYELIN IN LIPOPROTEIN METABOLISM
    Papasani Subbaiah; Fiscal Year: 2008
  3. CONFERENCE ON ARTERIOSCLEROSIS AND VASCULAR BIOLOGY
    Trudy Forte; Fiscal Year: 2004

Scientific Experts

  • Dominic S Ng
  • Menno Hoekstra
  • Papasani Subbaiah
  • G S Gerhard
  • Nancy R Webb
  • Trudy M Forte
  • M She
  • J P Paul
  • G Lambert
  • John S Parks
  • Lixin Li
  • Youn Kyung Kim
  • Philip W Connelly
  • Panagiotis Fotakis
  • Lauren Hager
  • Vassilis I Zannis
  • Adelina Duka
  • Richard G Lee
  • Seth G Thacker
  • Peristera Ioanna Petropoulou
  • Loredana Quadro
  • Hui Song
  • Joseph L Dixon
  • James W Furbee
  • Dimitris Kardassis
  • Alan T Remaley
  • Boris L Vaisman
  • Asma Tlili
  • Maximillian A Rogers
  • Jan Albert Kuivenhoven
  • Mohammad A Hossain
  • Lu Liu
  • Ulrike Taschler
  • Janet K Sawyer
  • Khosrow Adeli
  • Mark Naples
  • Hiroyuki Tanigawa
  • Veronica Hirsch-Reinshagen
  • Mohammad Anwar Hossain
  • Graham F Maguire
  • Maki Tsujita
  • Shinji Yokoyama
  • Yue Zhao
  • Angeliki Chroni
  • Lawrence L Rudel
  • David L Williams
  • Ai Hong Zhang
  • Xianghong Zhu
  • Ryan E Temel
  • Michael V Zuccaro
  • Eleni A Karavia
  • Xavier Rousset
  • Panagiota Stamou
  • Steven J Adelman
  • Kyriakos E Kypreos
  • Brianna K Costabile
  • Heidi L Collins
  • Alexandros Spyridonidis
  • Howard S Kruth
  • Xueting Jin
  • Abdalrahman Zarzour
  • Rebeka Rodas
  • Aikaterini Hatziri
  • Daniela A Malide
  • Iordanes Karagiannides
  • Lita Freeman
  • John Stonik
  • Safiya Esmail
  • Eugene Dafnis
  • Maureen Sampson
  • Jimmy F P Berbee
  • Stephen Demosky
  • Vassilios Theodoropoulos
  • Cheng ai Wu
  • Anita Brinker
  • Kalliopi Tzavlaki
  • Efstratios Stratikos
  • Christophe Noll
  • Arnaud Duchon
  • Yann Herault
  • Jean Maurice Delabar
  • Nathalie Janel
  • Sandrine Middendorp
  • Marie Jouan
  • Andreas Kateifides
  • Leonard von Eckardstein
  • Dimitra Georgiadou
  • Eva Benabou
  • J W Furbee
  • Mark M Kushnir

Detail Information

Publications54

  1. doi Lack of LCAT reduces the LPS-neutralizing capacity of HDL and enhances LPS-induced inflammation in mice
    Peristera Ioanna Petropoulou
    Pharmacology Department, University of Patras Medical School, Rio Achaias TK 26500, Greece
    Biochim Biophys Acta 1852:2106-15. 2015
    ..As lecithin-cholesterol acyltransferase (LCAT) is a critical enzyme in the maturation of HDL we investigated whether LCAT-deficient (Lcat(-/-)) mice present an ..
  2. pmc Increased plasma cholesterol esterification by LCAT reduces diet-induced atherosclerosis in SR-BI knockout mice
    Seth G Thacker
    Lipoprotein Metabolism Section, Cardiovascular Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
    J Lipid Res 56:1282-95. 2015
    b>LCAT, a plasma enzyme that esterifies cholesterol, has been proposed to play an antiatherogenic role, but animal and epidemiologic studies have yielded conflicting results...
  3. doi The Effect of Natural LCAT Mutations on the Biogenesis of HDL
    Panagiotis Fotakis
    Molecular Genetics, Boston University School of Medicine, 700 Albany Street, W509, Boston, Massachusetts 02118 2394, United States
    Biochemistry 54:3348-59. 2015
    We have investigated how the natural LCAT[T147I] and LCAT[P274S] mutations affect the pathway of biogenesis of HDL. Gene transfer of WT LCAT in LCAT(-/-) mice increased 11...
  4. pmc Tissue- and sex-specific effects of β-carotene 15,15' oxygenase (BCO1) on retinoid and lipid metabolism in adult and developing mice
    Youn Kyung Kim
    Department of Food Science and Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08091, USA
    Arch Biochem Biophys 572:11-8. 2015
    ....
  5. pmc Loss of β-carotene 15,15'-oxygenase in developing mouse tissues alters esterification of retinol, cholesterol and diacylglycerols
    Joseph L Dixon
    Department of Nutritional Sciences, Rutgers University, New Brunswick, NJ 08901, USA Rutgers Center for Lipid Research, Rutgers University, New Brunswick, NJ 08901, USA
    Biochim Biophys Acta 1841:34-43. 2014
    ..Furthermore, LCAT, ACAT1 and DGAT2 mRNA levels were also downregulated in CMOI-/- embryos...
  6. doi DYRK1A overexpression decreases plasma lecithin:cholesterol acyltransferase activity and apolipoprotein A-I levels
    Asma Tlili
    Universite Paris Diderot, Sorbonne Paris Cité, Unit of Functional and Adaptive Biology BFA, EAC CNRS 4413, Case 7104, 75205 Paris Cedex 13, France
    Mol Genet Metab 110:371-7. 2013
    ..Therefore, we characterized the role of DYRK1A overexpression on lecithin:cholesterol acyltransferase activity and expression in mouse models...
  7. pmc Cellular pregnenolone esterification by acyl-CoA:cholesterol acyltransferase
    Maximillian A Rogers
    Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    J Biol Chem 287:17483-92. 2012
    Pregnenolone (PREG) can be converted to PREG esters (PE) by the plasma enzyme lecithin: cholesterol acyltransferase (LCAT), and by other enzyme(s) with unknown identity...
  8. doi The role of lecithin:cholesterol acyltransferase in the modulation of cardiometabolic risks - a clinical update and emerging insights from animal models
    Dominic S Ng
    Keenan Research Center, Li Ka Shing Knowledge Institute, St Michael s Hospital, Canada
    Biochim Biophys Acta 1821:654-9. 2012
    Lecithin cholesterol acyltransferase (LCAT) is the key enzyme in mediating the esterification of cholesterol on circulating lipoproteins...
  9. pmc Regulation of plasma cholesterol esterification by sphingomyelin: effect of physiological variations of plasma sphingomyelin on lecithin-cholesterol acyltransferase activity
    Papasani Venkata Subbaiah
    Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Biochim Biophys Acta 1821:908-13. 2012
    ..models of mice which naturally differ in their plasma SM/PC ratios, to study the role of SM as a modulator of LCAT, the enzyme responsible for HDL maturation and the synthesis of cholesteryl esters (CE) in normal plasma...
  10. pmc Lecithin:cholesterol acyltransferase deficiency protects against cholesterol-induced hepatic endoplasmic reticulum stress in mice
    Lauren Hager
    Keenan Research Centre, Li Ka Shing Knowledge Institute, Department of Medicine, St Michael s Hospital, Toronto M5B 1W8, Canada
    J Biol Chem 287:20755-68. 2012
    We recently reported that lecithin:cholesterol acyltransferase (LCAT) knock-out mice, particularly in the LDL receptor knock-out background, are hypersensitive to insulin and resistant to high fat diet-induced insulin resistance (IR) and ..
  11. pmc ApoA-IV promotes the biogenesis of apoA-IV-containing HDL particles with the participation of ABCA1 and LCAT
    Adelina Duka
    Molecular Genetics, Boston University School of Medicine, Boston, MA, USA
    J Lipid Res 54:107-15. 2013
    The objective of this study was to establish the role of apoA-IV, ABCA1, and LCAT in the biogenesis of apoA-IV-containing HDL (HDL-A-IV) using different mouse models...
  12. pmc LCAT deficiency in mice is associated with a diminished adrenal glucocorticoid function
    Menno Hoekstra
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden, The Netherlands
    J Lipid Res 54:358-64. 2013
    ..Here we assessed adrenal glucocorticoid function in LCAT knockout (KO) mice to determine the specific contribution of HDL-cholesteryl esters to adrenal glucocorticoid ..
  13. ncbi Remodeling of HDL remnants generated by scavenger receptor class B type I
    Nancy R Webb
    Department of Internal Medicine, University of Kentucky Medical Center, Lexington, KY, USA
    J Lipid Res 45:1666-73. 2004
    ..Although LCAT-deficient plasma promoted only partial conversion, this deficiency was attributable to the nature of HDL particles ..
  14. ncbi Hypertriglyceridemia in lecithin-cholesterol acyltransferase-deficient mice is associated with hepatic overproduction of triglycerides, increased lipogenesis, and improved glucose tolerance
    Dominic S Ng
    Department of Medicine, St Michael s Hospital, Toronto, Ontario M5B 1A6, Canada
    J Biol Chem 279:7636-42. 2004
    ..We investigated the mechanism of HTG in the ldlr-/- x lcat-/- (double knockout (dko)) mice using the ldlr-/- x lcat+/+ (knock-out (ko)) littermates as control...
  15. ncbi Increased plasma HDL cholesterol levels and biliary cholesterol excretion in hamster by LCAT overexpression
    Ai Hong Zhang
    Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiology, Ministry of Education, Peking University, 38 Xue Yuan Road, Beijing 100083, PR China
    FEBS Lett 570:25-9. 2004
    Lecithin cholesterol acyltransferase (LCAT) is a key enzyme in the metabolism of high density lipoprotein (HDL), which has been found inversely correlated with atherosclerosis...
  16. pmc A novel in vivo lecithin-cholesterol acyltransferase (LCAT)-deficient mouse expressing predominantly LpX is associated with spontaneous glomerulopathy
    Xianghong Zhu
    Department of Medicine, St Michael s Hospital West Annex 2 015, 38 Shuter Street, Toronto, Ontario M5B 1A6 Canada
    Am J Pathol 165:1269-78. 2004
    Complete lecithin cholesterol acyltransferase (LCAT) deficiency is a rare genetic cause of extreme reduction in high density lipoproteins and there is a high prevalence of chronic renal dysfunction that may progress to renal failure...
  17. ncbi Plasma cholesteryl esters provided by lecithin:cholesterol acyltransferase and acyl-coenzyme a:cholesterol acyltransferase 2 have opposite atherosclerotic potential
    Richard G Lee
    Arteriosclerosis Research Program, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Circ Res 95:998-1004. 2004
    ..ACAT2 is a proatherogenic enzyme that contributes cholesteryl esters (CEs) to apoB-containing lipoproteins, whereas LCAT is an antiatherogenic enzyme that facilitates reverse cholesterol transport by esterifying free cholesterol on HDL ..
  18. ncbi Apolipoprotein E is the major physiological activator of lecithin-cholesterol acyltransferase (LCAT) on apolipoprotein B lipoproteins
    Yue Zhao
    Department of Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Biochemistry 44:1013-25. 2005
    Our previous studies have indicated that lecithin-cholesterol acyltransferase (LCAT) contributes significantly to the apoB lipoprotein cholesteryl ester (CE) pool...
  19. ncbi ACAT2 contributes cholesteryl esters to newly secreted VLDL, whereas LCAT adds cholesteryl ester to LDL in mice
    Richard G Lee
    Arteriosclerosis Research Program, Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    J Lipid Res 46:1205-12. 2005
    The relative contributions of ACAT2 and LCAT to the cholesteryl ester (CE) content of VLDL and LDL were measured. ACAT2 deficiency led to a significant decrease in the percentage of CE (37.2 +/- 2.1% vs. 3.9 +/- 0...
  20. ncbi Coordinated alteration of hepatic gene expression in fatty acid and triglyceride synthesis in LCAT-null mice is associated with altered PUFA metabolism
    Hui Song
    Department of Medicine, St Michael s Hospital, Toronto, ON M5B 1A6, Canada
    Am J Physiol Endocrinol Metab 290:E17-E25. 2006
    Complete lecithin:cholesterol acyltransferase (LCAT) deficiency is associated with fasting hypertriglyceridemia (HTG)...
  21. ncbi Point mutations in apolipoprotein A-I mimic the phenotype observed in patients with classical lecithin:cholesterol acyltransferase deficiency
    Angeliki Chroni
    Molecular Genetics, Whitaker Cardiovascular Institute, Department of Medicine, Center for Advanced Biomedical Research, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Biochemistry 44:14353-66. 2005
    ..around the kinks flanking helices 4 and 6 of apoA-I and of the deletion of helix 6 on the in vivo activity of LCAT and the biogenesis of HDL...
  22. ncbi LCAT-null mice develop improved hepatic insulin sensitivity through altered regulation of transcription factors and suppressors of cytokine signaling
    Lixin Li
    Department of Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Am J Physiol Endocrinol Metab 293:E587-94. 2007
    We previously reported that LCAT-deficient mice develop not only low HDL-cholesterol but also hypertriglyceridemia, hepatic triglyceride (TG) overproduction, and, unexpectedly, improved hepatic insulin sensitivity and reduced hepatic TG ..
  23. pmc LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins
    Veronica Hirsch-Reinshagen
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada
    J Lipid Res 50:885-93. 2009
    ..However, brain lipid metabolism is not completely understood. In plasma, LCAT catalyses the esterification of free cholesterol on circulating lipoproteins, a key step in the maturation of HDL...
  24. pmc Lecithin: cholesterol acyltransferase expression has minimal effects on macrophage reverse cholesterol transport in vivo
    Hiroyuki Tanigawa
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Circulation 120:160-9. 2009
    Lecithin:cholesterol acyltransferase (LCAT) catalyzes the formation of plasma cholesteryl ester, plays a key role in high-density lipoprotein metabolism, and has been believed to be critical in the process of reverse cholesterol transport ..
  25. doi Cholesterol homeostasis in ABCA1/LCAT double-deficient mouse
    Mohammad Anwar Hossain
    Biochemistry, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Biochim Biophys Acta 1791:1197-205. 2009
    ..in mice with the two major cholesterol transport pathways for catabolism interrupted by disrupting abca1, lcat, or both. Plasma HDL markedly decreased in these genotype but LDL/VLDL decreased only in the double deficiency...
  26. pmc Lecithin cholesterol acyltransferase null mice are protected from diet-induced obesity and insulin resistance in a gender-specific manner through multiple pathways
    Lixin Li
    Keenan Research Centre, Li Ka Shing Knowledge Institute, Department of Medicine, St Michael s Hospital, Toronto M5B 1W8, Canada
    J Biol Chem 286:17809-20. 2011
    Complete lecithin cholesterol acyltransferase (LCAT) deficiency uniformly results in a profound HDL deficiency...
  27. pmc Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance
    Ulrike Taschler
    Institute of Molecular Biosciences, University of Graz, A 8010 Graz, Austria
    J Biol Chem 286:17467-77. 2011
    ..Defective degradation of 2-AG does not provoke cannabinoid-like effects on feeding behavior, lipid storage, and energy expenditure, which may be explained by desensitization of CBR...
  28. ncbi Mouse K-Cl cotransporter KCC1: cloning, mapping, pathological expression, and functional regulation
    W Su
    Molecular Medicine and Renal Units, Beth Israel Deaconess Medical Center, Boston 02215, USA
    Am J Physiol 277:C899-912. 1999
    ..These reagents and findings will expedite studies of KCC1 structure-function relationships and of the pathobiology of KCC1-mediated K-Cl cotransport...
  29. ncbi Tissue-specific expression, developmental regulation, and chromosomal mapping of the lecithin: cholesterol acyltransferase gene. Evidence for expression in brain and testes as well as liver
    C H Warden
    Department of Medicine, University of California, Los Angeles 90024
    J Biol Chem 264:21573-81. 1989
    Lecithin:cholesterol acyltransferase (LCAT) catalyzes the esterification of cholesterol in high density lipoproteins, thereby facilitating transport of excess cholesterol from peripheral tissues to liver...
  30. ncbi Effect of apolipoprotein A-I deficiency on lecithin:cholesterol acyltransferase activation in mouse plasma
    J S Parks
    Department of Comparative Medicine, Bowman Gray School of Medicine of Wake Forest University, Winston Salem, NC 27157, USA
    J Lipid Res 36:349-55. 1995
    Plasma cholesteryl ester (CE) synthesis by lecithin cholesterol acyltransferase (LCAT) is activated by apolipoprotein (apo)A-I...
  31. ncbi Assignment of the mouse vesicular monoamine transporter genes, Slc18a1 and Slc18a2, to chromosomes 8 and 19 by linkage analysis
    A Roghani
    Department of Neurology, University of California, Los Angeles, California 90095, USA
    Mamm Genome 7:393-4. 1996
  32. ncbi Targeted disruption of the mouse lecithin:cholesterol acyltransferase (LCAT) gene. Generation of a new animal model for human LCAT deficiency
    N Sakai
    Molecular Disease Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1666, USA
    J Biol Chem 272:7506-10. 1997
    We have established a mouse model for human LCAT deficiency by performing targeted disruption of the LCAT gene in mouse embryonic stem cells. Homozygous LCAT-deficient mice were healthy at birth and fertile...
  33. ncbi Disruption of the murine lecithin:cholesterol acyltransferase gene causes impairment of adrenal lipid delivery and up-regulation of scavenger receptor class B type I
    D S Ng
    Human Genome Center, Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
    J Biol Chem 272:15777-81. 1997
    Lecithin:cholesterol acyltransferase (LCAT) is the major determinant of the cholesteryl ester (CE) content of high density lipoprotein (HDL) in plasma...
  34. ncbi Adenoviral vector-mediated overexpression of serum amyloid A in apoA-I-deficient mice
    N R Webb
    Department of Internal Medicine, University of Kentucky Medical Center, Lexington 40536, USA
    J Lipid Res 38:1583-90. 1997
    ..We conclude that SAA is unable to substitute for apoA-I in HDL particle formation...
  35. ncbi Mapping of the gene for calreticulin (Calr) to mouse chromosome 8
    K Rooke
    Department of Medicine, University of California Los Angeles 90095, USA
    Mamm Genome 8:870-1. 1997
  36. ncbi Molecular identification and expression of erythroid K:Cl cotransporter in human and mouse erythroleukemic cells
    C M Pellegrino
    Division of Hematology, Albert Einstein College of Medicine Montefiore Medical Center, 111 East 210th Street, Bronx, NY, USA
    Blood Cells Mol Dis 24:31-40. 1998
    ....
  37. ncbi Targeted disruption of the murine lecithin:cholesterol acyltransferase gene is associated with reductions in plasma paraoxonase and platelet-activating factor acetylhydrolase activities but not in apolipoprotein J concentration
    T M Forte
    Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94729, USA
    J Lipid Res 40:1276-83. 1999
    Lecithin:cholesteryl acyltransferase (LCAT) deficiency resulting from targeted disruption of the Lcat gene in the mouse is associated with dramatic decreases in HDL concentration and the accumulation of nascent HDL in the plasma...
  38. ncbi Somatic gene therapy for dyslipidemias
    M Belalcazar
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Lab Clin Med 134:194-214. 1999
    ..We highlight some recent advances in adenoviral vector development that make this vector an attractive system for clinical trials...
  39. ncbi Inhibition of intimal lipid deposition in human apolipoprotein A1 transgenic mice
    M She
    Department of Pathology, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
    Clin Exp Pharmacol Physiol 26:833-4. 1999
    ..Expression of platelet-derived growth factor-B, c-myc and c-fos proteins was much weaker in smooth muscle cells at the aortic sinus in transgenic mice...
  40. ncbi Fractional efflux and net change in cellular cholesterol content mediated by sera from mice expressing both human apolipoprotein AI and human lecithin:cholesterol acyltransferase genes
    N Fournier
    Laboratoire de biochimie appliquée, Faculte des Sciences Pharmaceutiques et Biologiques, Chatenay Malabry, France
    Atherosclerosis 147:227-35. 1999
    Human lecithin:cholesterol acyltransferase (LCAT) is a key enzyme in the metabolism of cholesterol and is postulated to participate in the physiological process called reverse cholesterol transport...
  41. ncbi Gene mapping on mouse chromosome 8 by interspecific crosses: new data on a linkage group conserved on human chromosome 16q
    G Scherer
    Institute of Human Genetics, Freiburg, Federal Republic of Germany
    Genomics 5:275-82. 1989
    ..16q, including the loci for chymotrypsinogen B (Ctrb), haptoglobin (Hp), lecithin:cholesterol acyltransferase (Lcat), metallothionein-1,-2 (Mt-1,-2), tyrosine aminotransferase (Tat), and uvomorulin (Um)...
  42. ncbi Analysis of glomerulosclerosis and atherosclerosis in lecithin cholesterol acyltransferase-deficient mice
    G Lambert
    Molecular Disease Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:15090-8. 2001
    ..and the variable development of atherosclerosis in patients with familial lecithin cholesterol acyl transferase (LCAT) deficiency, we generated LCAT knockout (KO) mice and cross-bred them with apolipoprotein (apo) E KO, low density ..
  43. ncbi Effect of up-regulating individual steps in the reverse cholesterol transport pathway on reverse cholesterol transport in normolipidemic mice
    K Alam
    Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Biol Chem 276:15641-9. 2001
    ..Overexpression of 7alpha-hydroxylase, Scavenger receptor B1, lecithin:cholesterol acyltransferase (LCAT), or apoA-I in the liver did not stimulate cholesterol efflux from any extrahepatic tissue...
  44. ncbi Effect of mutations of N- and C-terminal charged residues on the activity of LCAT
    F Peelman
    Laboratory for Lipoprotein Chemistry, Faculty of Medicine, Flanders Interuniversity Institute for Biotechnology, Universiteit Gent, B 9000 Ghent, Belgium
    J Lipid Res 42:471-9. 2001
    On the basis of structural homology calculations, we previously showed that lecithin:cholesterol acyltransferase (LCAT), like lipases, belongs to the alpha/beta hydrolase fold family...
  45. ncbi Susceptibility and negative epistatic loci contributing to type 2 diabetes and related phenotypes in a KK/Ta mouse model
    T Shike
    Division of Nephrology, Department of Medicine, and the Department of Pathology, Juntendo University School of Medicine, Tokyo, Japan
    Diabetes 50:1943-8. 2001
    ..However, there appear to be common genes contributing to different disease phenotypes. There are potentially important candidate genes that may be relevant to the disease...
  46. ncbi Alteration of plasma HDL cholesteryl ester composition with transgenic expression of a point mutation (E149A) of human LCAT
    J W Furbee
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1040, USA
    J Lipid Res 42:1626-35. 2001
    We have previously identified a single amino acid mutation (hE149A) in human LCAT that increases its in vitro reactivity with phosphatidylcholine species containing sn-2 arachidonate (Wang et al. 1997. J. Biol. Chem. 272: 280-286)...
  47. ncbi Genetic differences in hepatic lipid peroxidation potential and iron levels in mice
    Glenn S Gerhard
    Department of Pathology, Penn State College of Medicine, Hershey, PA, USA
    Mech Ageing Dev 123:167-76. 2002
    ..0006. At least two potentially relevant candidate genes reside close to this chromosomal position. Hepatic lipid peroxidation potential appears to be a strain related trait in mice that is amenable to QTL analysis...
  48. ncbi Lecithin:cholesterol acyltransferase deficiency increases atherosclerosis in the low density lipoprotein receptor and apolipoprotein E knockout mice
    James W Furbee
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, North Carolina 27157 1040, USA
    J Biol Chem 277:3511-9. 2002
    The purpose of the present study was to test the hypothesis that lecithin:cholesterol acyltransferase (LCAT) deficiency would accelerate atherosclerosis development in low density lipoprotein (LDL) receptor (LDLr-/-) and apoE (apoE-/-) ..
  49. ncbi Oxidative stress is markedly elevated in lecithin:cholesterol acyltransferase-deficient mice and is paradoxically reversed in the apolipoprotein E knockout background in association with a reduction in atherosclerosis
    Dominic S Ng
    Department of Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    J Biol Chem 277:11715-20. 2002
    Complete lecithin:cholesterol acyltransferase (LCAT) deficiency is a rare cause of severe hypoalphalipoproteinemia, but the affected subjects are surprisingly not particularly prone to premature coronary heart disease...
  50. ncbi In vivo contribution of LCAT to apolipoprotein B lipoprotein cholesteryl esters in LDL receptor and apolipoprotein E knockout mice
    James W Furbee
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1040, USA
    J Lipid Res 43:428-37. 2002
    Previous studies have indicated that LCAT may play a role in the generation of cholesteryl esters (CE) in plasma apolipoprotein B (apoB) lipoproteins...
  51. ncbi Altered activities of anti-atherogenic enzymes LCAT, paraoxonase, and platelet-activating factor acetylhydrolase in atherosclerosis-susceptible mice
    Trudy M Forte
    Life Sciences Division MS 1 222, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    J Lipid Res 43:477-85. 2002
    We examined whether the putative anti-atherogenic enzymes LCAT, paraoxonase (PON), and platelet-activating factor acetylhydrolase (PAF-AH) are impaired in 8 week old atherosclerosis susceptible apolipoprotein E (apoE)(-/-) and LDL ..
  52. ncbi Cholesteryl ester transfer protein expressed in lecithin cholesterol acyltransferase-deficient mice
    Cheng ai Wu
    Biochemistry, Cell Biology, and Metabolism, Nagoya City University Graduate School of Medical Science, Nagoya, Japan
    Arterioscler Thromb Vasc Biol 22:1347-53. 2002
    Regulation of plasma cholesteryl ester transfer protein (CETP) concentration was studied in lecithin-cholesterol acyltransferase (LCAT)-knockout mice.
  53. ncbi Enhancement of scavenger receptor class B type I-mediated selective cholesteryl ester uptake from apoA-I(-/-) high density lipoprotein (HDL) by apolipoprotein A-I requires HDL reorganization by lecithin cholesterol acyltransferase
    Ryan E Temel
    Department of Pharmacological Sciences, University Medical Center, State University of New York, Stony Brook, New York 11794, USA
    J Biol Chem 278:4792-9. 2003
    ..These data suggest that the conformation of apoA-I at the HDL surface is important for the efficient transfer of CE to the cell...
  54. ncbi High-resolution mapping of a linkage group on mouse chromosome 8 conserved on human chromosome 16Q
    J Becker-Follmann
    Institute of Human Genetics, University of Freiburg, Breisacherstr 33, D 79106 Freiburg, Germany
    Mamm Genome 8:172-7. 1997
    ..1-Mmp2-0.2-Ces1,Es1, Es22-1.2-Mt1,D8Mit15-2.2-Got2, D8Mit11-3.7-Es30-0.3-Es2, Es7-0.9-Ctra1,Lcat-0.3-Cdh1, Cadp, Nmor1, D8Mit12-0.2-Mov34-2.5-Hp,Tat-0.2-Zfp4-1.6-Zfp1,+ ++Ctrb-10.9-e...

Research Grants3

  1. LCAT AND PATHOPHYSIOLOGY OF PHOSPHOLIPID SPECIES
    Papasani Subbaiah; Fiscal Year: 2002
    ..Abstract): The major goal of the project is to investigate the role of lecithin-cholesterol acyltransferase (LCAT) in the metabolism of phospholipid species, and its relation to atherogenesis...
  2. ROLE OF SPHINGOMYELIN IN LIPOPROTEIN METABOLISM
    Papasani Subbaiah; Fiscal Year: 2008
    ..transport, focusing on the efflux of cholesterol from macrophages, and on the esterification of cholesterol by LCAT. The novel hypothesis that SM acts as a chaperone for cholesterol during ABCG1 transporter-mediated efflux will be ..
  3. CONFERENCE ON ARTERIOSCLEROSIS AND VASCULAR BIOLOGY
    Trudy Forte; Fiscal Year: 2004
    ..abstract_text> ..