L selectin

Summary

Gene Symbol: L selectin
Description: selectin, lymphocyte
Alias: AI528707, CD62L, L-selectin, LECAM-1, Lnhr, Ly-22, Ly-m22, Lyam-1, Lyam1, L-selectin, CD62 antigen-like family member L, LAM-1, LECAM1, leukocyte adhesion molecule 1, leukocyte-endothelial cell adhesion molecule 1, lymph node homing receptor, lymphocyte antigen 22, lymphocyte surface MEL-14 antigen
Species: mouse

Top Publications

  1. ncbi The selectins: vascular adhesion molecules
    T F Tedder
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    FASEB J 9:866-73. 1995
  2. pmc L-selectin from human, but not from mouse neutrophils binds directly to E-selectin
    O Zöllner
    Institute of Cell Biology, ZMBE, University of Munster, Germany
    J Cell Biol 136:707-16. 1997
  3. ncbi Ligation of L-selectin through conserved regions within the lectin domain activates signal transduction pathways and integrin function in human, mouse, and rat leukocytes
    D A Steeber
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 159:952-63. 1997
  4. ncbi L-selectin-dependent lymphoid occupancy is required to induce alloantigen-specific tolerance
    Yalai Bai
    Carl C Icahn Institute for Gene Therapy and Molecular Medicine and Recanati Miller Transplant Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 168:1579-89. 2002
  5. pmc Lymphocyte homing to bronchus-associated lymphoid tissue (BALT) is mediated by L-selectin/PNAd, alpha4beta1 integrin/VCAM-1, and LFA-1 adhesion pathways
    Baohui Xu
    Dept of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    J Exp Med 197:1255-67. 2003
  6. pmc Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking
    Linda V Sinclair
    Department of Cell Biology and Immunology, University of Dundee, Dundee DD1 5EH, UK
    Nat Immunol 9:513-21. 2008
  7. ncbi L-selectin or ICAM-1 deficiency reduces an immediate-type hypersensitivity response by preventing mast cell recruitment in repeated elicitation of contact hypersensitivity
    Yuka Shimada
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Immunol 170:4325-34. 2003
  8. ncbi Kruppel-like factor 2 controls T cell trafficking by activating L-selectin (CD62L) and sphingosine-1-phosphate receptor 1 transcription
    Ailin Bai
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, 40 Ames Street, Cambridge, MA 02139, USA
    J Immunol 178:7632-9. 2007
  9. pmc Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34
    P R Baum
    Department of Gene Expression, Immunex R and D Corporation, Seattle, WA 98101
    EMBO J 13:3992-4001. 1994
  10. ncbi Differential expression of ICAM-1 and LFA-1 versus L-selectin and VCAM-1 in autoimmune insulitis of NOD mice and association with both Th1- and Th2-type infiltrates
    S Martin
    Diabetes Research Institute, Heinrich Heine University, Dusseldorf, Germany
    J Autoimmun 9:637-43. 1996

Research Grants

  1. Structure/Functional Characterization of vWF-A1 Domain
    THOMAS DIACOVO; Fiscal Year: 2007
  2. Novel Dendritic Cell Chemoattractant and Receptor
    Eugene Butcher; Fiscal Year: 2009
  3. Mucosal Therapy for Autoimmunity
    David Pascual; Fiscal Year: 2008
  4. MUCOSAL TRANSGENE VACCINATION FOR HIV
    David Pascual; Fiscal Year: 2003
  5. TARGETED DNA DELIVERY FOR SALIVARY IGA RESPONSES
    David Pascual; Fiscal Year: 2004
  6. Mucosal Vaccines for Plague
    David Pascual; Fiscal Year: 2006
  7. MUCOSAL IMMUNITY ELICITED BY SALMONELLA VACCINE DELIVERY
    David Pascual; Fiscal Year: 2009
  8. Mucosal Lymphocyte Homing in the Head and Neck
    David Pascual; Fiscal Year: 2008
  9. GLOBIN SWITCHING AND ERYTHROID DIFFERENTIATION
    Thalia Papayannopoulou; Fiscal Year: 2002
  10. Tolerogenic DC as Therapeutic Agents in GVHD
    Eugene C Butcher; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications118 found, 100 shown here

  1. ncbi The selectins: vascular adhesion molecules
    T F Tedder
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    FASEB J 9:866-73. 1995
    ..Future studies are focused on how the selectins interact with the increasing array of other adhesion molecules and inflammatory mediators...
  2. pmc L-selectin from human, but not from mouse neutrophils binds directly to E-selectin
    O Zöllner
    Institute of Cell Biology, ZMBE, University of Munster, Germany
    J Cell Biol 136:707-16. 1997
    ..The clear difference between human and mouse L-selectin suggests that E-selectin-binding carbohydrate moieties are attached to different protein scaffolds in different species...
  3. ncbi Ligation of L-selectin through conserved regions within the lectin domain activates signal transduction pathways and integrin function in human, mouse, and rat leukocytes
    D A Steeber
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 159:952-63. 1997
    ..Signaling through L-selectin may enhance leukocyte-endothelial cell interactions by serving as an activation/priming step during rolling, thereby promoting subsequent firm cell-cell adhesion in the presence of inflammatory mediators...
  4. ncbi L-selectin-dependent lymphoid occupancy is required to induce alloantigen-specific tolerance
    Yalai Bai
    Carl C Icahn Institute for Gene Therapy and Molecular Medicine and Recanati Miller Transplant Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Immunol 168:1579-89. 2002
    ..Concurrent administration of anti-L-selectin (CD62L) Ab, which prevents lymph node homing, prevents indefinite allograft survival and tolerance...
  5. pmc Lymphocyte homing to bronchus-associated lymphoid tissue (BALT) is mediated by L-selectin/PNAd, alpha4beta1 integrin/VCAM-1, and LFA-1 adhesion pathways
    Baohui Xu
    Dept of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    J Exp Med 197:1255-67. 2003
    ..This high level of involvement of alpha4beta1 integrin/VCAM-1 is unique among secondary lymphoid tissues, and may help unify lymphocyte migration pathways and immune responses in BALT and other bronchopulmonary tissues...
  6. pmc Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking
    Linda V Sinclair
    Department of Cell Biology and Immunology, University of Dundee, Dundee DD1 5EH, UK
    Nat Immunol 9:513-21. 2008
    ..The key lymph node-homing receptors CD62L (L-selectin) and CCR7 were highly expressed on naive T lymphocytes but were downregulated after immune activation...
  7. ncbi L-selectin or ICAM-1 deficiency reduces an immediate-type hypersensitivity response by preventing mast cell recruitment in repeated elicitation of contact hypersensitivity
    Yuka Shimada
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Immunol 170:4325-34. 2003
    ....
  8. ncbi Kruppel-like factor 2 controls T cell trafficking by activating L-selectin (CD62L) and sphingosine-1-phosphate receptor 1 transcription
    Ailin Bai
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, 40 Ames Street, Cambridge, MA 02139, USA
    J Immunol 178:7632-9. 2007
    ..In this study, we show that in reporter gene assays KLF2 directly activates the promoters of both CD62L and sphingosine-1-phosphate receptor 1 (S1P1), whose expression is critical for T cell egress from the thymus and ..
  9. pmc Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34
    P R Baum
    Department of Gene Expression, Immunex R and D Corporation, Seattle, WA 98101
    EMBO J 13:3992-4001. 1994
    ..In addition, the HTLV-1 regulation of gp34 suggests a possible connection between virally induced pathogenesis and the OX40 system...
  10. ncbi Differential expression of ICAM-1 and LFA-1 versus L-selectin and VCAM-1 in autoimmune insulitis of NOD mice and association with both Th1- and Th2-type infiltrates
    S Martin
    Diabetes Research Institute, Heinrich Heine University, Dusseldorf, Germany
    J Autoimmun 9:637-43. 1996
    ..ICAM-1 and LFA-1 expression is seen prior to L-selectin and VCAM-1. However, adhesion molecule expression during Th1 versus Th2 cell infiltration is very similar, suggesting similar adhesion molecule requirements of the two Th subsets...
  11. ncbi Leukocyte entry into sites of inflammation requires overlapping interactions between the L-selectin and ICAM-1 pathways
    D A Steeber
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 163:2176-86. 1999
    ..Thus, members of the selectin and Ig families function synergistically to mediate optimal leukocyte rolling and entry into tissues, which is essential for the generation of effective inflammatory responses in vivo...
  12. ncbi Selectin-independent leukocyte rolling and adhesion in mice deficient in E-, P-, and L-selectin and ICAM-1
    S B Forlow
    Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Am J Physiol Heart Circ Physiol 280:H634-41. 2001
    ..Comparison of our data with mice lacking individual or other combinations of adhesion molecules reveal that elimination of more adhesion molecules further reduces leukocyte recruitment but the effect is less than additive...
  13. ncbi ICAM-1-dependent pathways regulate colonic eosinophilic inflammation
    Elizabeth Forbes
    Allergy and Inflammation Research Group, Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Leukoc Biol 80:330-41. 2006
    ..These studies demonstrate that beta2 -integrin/ICAM-1-dependent pathways are integral to eosinophil recruitment into the colon during GI inflammation associated with colonic injury...
  14. ncbi The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics
    Levi G Ledgerwood
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Immunol 9:42-53. 2008
    ..Thus, the increased sphingosine 1-phosphate present in inflamed peripheral tissues may induce T cell retention and suppress T cell egress...
  15. ncbi Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice
    M L Arbones
    Cell Genesys, Incorporated, Foster City, California 94404
    Immunity 1:247-60. 1994
    ..Thus, L-selectin plays an essential role in leukocyte homing to lymphoid tissues and sites of inflammation...
  16. pmc L-selectin-deficient mice have impaired leukocyte recruitment into inflammatory sites
    T F Tedder
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Exp Med 181:2259-64. 1995
    ..These results demonstrate that L-selectin plays a prominent role in leukocyte homing to nonlymphoid tissues during inflammation and that blocking this process can be beneficial during pathological inflammatory responses...
  17. pmc Impaired primary T cell responses in L-selectin-deficient mice
    J Xu
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Exp Med 183:589-98. 1996
    ..L-selectin does not appear to be rate limiting for the events leading to antigen-driven neutrophil recruitment, since normal DTH responses are obtained at late time points after immunization...
  18. ncbi Lyphocyte migration in L-selectin-deficient mice. Altered subset migration and aging of the immune system
    D A Steeber
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 157:1096-106. 1996
    ..Therefore, L-selectin-dependent pathways of lymphocyte migration are important for the normal migration of both naive and memory lymphocytes...
  19. ncbi Humoral immune responses in L-selectin-deficient mice
    D A Steeber
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 157:4899-907. 1996
    ....
  20. pmc The route of antigen entry determines the requirement for L-selectin during immune responses
    M D Catalina
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235 9072, USA
    J Exp Med 184:2341-51. 1996
    ....
  21. ncbi Intrinsic differences in L-selectin expression levels affect T and B lymphocyte subset-specific recirculation pathways
    M L Tang
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 160:5113-21. 1998
    ..Thus, the differential migration of T and B lymphocyte subsets to lymphoid tissues is regulated in part by subset-specific differences in L-selectin expression levels...
  22. ncbi The roles of L-selectin, beta 7 integrins, and P-selectin in leukocyte rolling and adhesion in high endothelial venules of Peyer's patches
    E J Kunkel
    Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville 22908, USA
    J Immunol 161:2449-56. 1998
    ..In situ, beta 7 integrins and L-selectin account for all lymphocyte homing to Peyer's patches, but P-selectin-dependent rolling, as induced by minimal trauma, may support trafficking of effector T lymphocytes to Peyer's patches...
  23. ncbi Mice lacking two or all three selectins demonstrate overlapping and distinct functions for each selectin
    U Jung
    Department of Biomedical Engineering, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    J Immunol 162:6755-62. 1999
    ..We conclude that any one of the selectins can support some neutrophil recruitment but eliminating all three selectins significantly impairs neutrophil recruitment...
  24. ncbi L-selectin facilitates emigration and extravascular locomotion of leukocytes during acute inflammatory responses in vivo
    M J Hickey
    Immunology Research Group, University of Calgary, Calgary, Alberta, Canada
    J Immunol 165:7164-70. 2000
    ..These findings indicate that L-selectin is important in enabling leukocytes to respond effectively to chemotactic stimuli in inflamed tissues...
  25. pmc L-selectin shedding regulates leukocyte recruitment
    A Hafezi-Moghadam
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
    J Exp Med 193:863-72. 2001
    ..These observations help to resolve the apparent discrepancy between the minor contribution of L-selectin to rolling and the significant leukocyte recruitment defect in L-selectin knockout mice...
  26. pmc Importance of primary capture and L-selectin-dependent secondary capture in leukocyte accumulation in inflammation and atherosclerosis in vivo
    E E Eriksson
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Exp Med 194:205-18. 2001
    ..What is more, secondary capture occurs on atherosclerotic lesions, a fact that provides the first evidence for roles of L-selectin in leukocyte accumulation in atherogenesis...
  27. pmc CD11c(+)B220(+)Gr-1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells
    H Nakano
    Department of Medicine and Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA
    J Exp Med 194:1171-8. 2001
    ..These cells also display a strain-specific variation in frequency, being fivefold increased in the LNs of BALB/c relative to C57BL/6 mice. These CD11c(+)CD11b(-)B220(+)Gr-1(+) cells appear to be the murine equivalent of human pDCs...
  28. ncbi P-, E-, and L-selectin mediate migration of activated CD8+ T lymphocytes into inflamed skin
    Takako Hirata
    Center for Hemostasis and Thrombosis Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Immunol 169:4307-13. 2002
    ..P- and E-selectin-independent migration of Tc1 cells into the inflamed skin was predominantly mediated by L-selectin. These observations indicate that all three selectins can mediate Tc1 cell migration into the inflamed skin...
  29. pmc P-selectin glycoprotein ligand-1 mediates L-selectin-dependent leukocyte rolling in venules
    Markus Sperandio
    University of Virginia Health System, Cardiovascular Research Center, MR5 Bldg, Rm 1013, P O Box 801 394, Charlottesville, VA 22908 1394, USA
    J Exp Med 197:1355-63. 2003
    ..L-selectin binding to PSGL-1 initiates tethering events that enable L-selectin-independent leukocyte-endothelial interactions. These findings provide a molecular mechanism for the inflammatory defects seen in L-selectin-deficient mice...
  30. ncbi Leukocyte migration is regulated by L-selectin endoproteolytic release
    Guglielmo M Venturi
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Immunity 19:713-24. 2003
    ..Thus, endoproteolytic cleavage regulates both homeostatic and activation-induced changes in cell surface L-selectin density, which directs the migration patterns of activated lymphocytes and neutrophils in vivo...
  31. pmc L- and P-selectins collaborate to support leukocyte rolling in vivo when high-affinity P-selectin-P-selectin glycoprotein ligand-1 interaction is inhibited
    Victoria C Ridger
    Cardiovascular Research Unit, University of Sheffield, Sheffield, UK
    Am J Pathol 166:945-52. 2005
    ..Together these data suggest that leukocytes can continue to roll in the absence of optimal P-selectin/PSGL-1 interaction using an alternative mechanism that involves P-selectin-, L-selectin-, and sLe(x)-bearing ligands...
  32. pmc Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent
    Elena Galkina
    Department of Biomedical Engineering, University of Virginia, Health Sciences Center, Charlottesville, VA 22908, USA
    J Exp Med 203:1273-82. 2006
    ..Atherosclerosis induces the recruitment of macrophages and dendritic cells that support antigen presentation...
  33. pmc Early establishment of diverse T cell receptor profiles for influenza-specific CD8(+)CD62L(hi) memory T cells
    Katherine Kedzierska
    Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Melbourne, Australia
    Proc Natl Acad Sci U S A 103:9184-9. 2006
    ..indicates that prominent clonotypes bearing "public" or "shared" T cell receptors (TCRs) subset early into CD62L(hi) and CD62L(lo) populations...
  34. doi No detectable endothelial- or leukocyte-derived L-selectin ligand activity on the endothelium in inflamed cremaster muscle venules
    Einar E Eriksson
    Department of Physiology and Pharmacology, Karolinska Institutet, S 171 77 Stockholm, Sweden
    J Leukoc Biol 84:93-103. 2008
    ..These data demonstrate that expression of L-selectin on leukocytes is insufficient for mediating rolling and efficient recruitment of leukocytes in inflammation...
  35. pmc Optimal selectin-mediated rolling of leukocytes during inflammation in vivo requires intercellular adhesion molecule-1 expression
    D A Steeber
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 95:7562-7. 1998
    ..Thus, members of the selectin and Ig families function synergistically to mediate optimal leukocyte rolling in vivo, which is essential for the generation of effective inflammatory responses...
  36. ncbi Core 2 oligosaccharide biosynthesis distinguishes between selectin ligands essential for leukocyte homing and inflammation
    L G Ellies
    Howard Hughes Medical Institute, Division of Cellular and Molecular Medicine, University of California San Diego, La Jolla 92093, USA
    Immunity 9:881-90. 1998
    ..These studies indicate that core 2 oligosaccharide biosynthesis segregates the physiologic roles of selectins and reveal a function for the C2 GlcNAcT in myeloid homeostasis and inflammation...
  37. ncbi The mouse lymph node homing receptor is identical with the lymphocyte cell surface marker Ly-22: role of the EGF domain in endothelial binding
    M H Siegelman
    Department of Pathology, Stanford University School of Medicine, California 94305
    Cell 61:611-22. 1990
    The lymph node homing receptor core polypeptide (mLHRc) is composed of a tandem collection of domains: a lectin domain, an epidermal growth factor (EGF) domain, and two repeats common in complement regulatory proteins...
  38. ncbi Mouse lymph node homing receptor cDNA clone encodes a glycoprotein revealing tandem interaction domains
    M H Siegelman
    Department of Pathology, Stanford University School of Medicine, CA 94305
    Science 243:1165-72. 1989
    Isolation of a clone encoding the mouse lymph node homing receptor reveals a deduced protein with an unusual protein mosaic architecture, containing a separate carbohydrate-binding (lectin) domain, an epidermal growth factor-like (EGF) ..
  39. ncbi Mac-1 (CD11b/CD18) and CD45 mediate the adhesion of hematopoietic progenitor cells to stromal cell elements via recognition of stromal heparan sulfate
    D R Coombe
    Sir William Dunn School of Pathology, University of Oxford, UK
    Blood 84:739-52. 1994
    ..The data suggest that heparan sulfate on the 3T3 cell surface is a ligand for both CD45 and Mac-1, but the two molecules recognize different heparan sulfate structural motifs...
  40. ncbi Purification and quantification of L-selectin-reactive GlyCAM-1 from mouse serum
    M S Singer
    Department of Anatomy, University of California, San Francisco 94143 0452, USA
    J Immunol Methods 196:153-61. 1996
    ..This material may now be used to address the biological functions of GlyCAM-1 and to further define its structural features...
  41. ncbi L-selectin is involved in lymphocyte migration to sites of inflammation in the skin: delayed rejection of allografts in L-selectin-deficient mice
    M L Tang
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 158:5191-9. 1997
    ..These findings delineate an important role for L-selectin in lymphocyte recruitment to cutaneous sites of inflammation...
  42. ncbi Role of primary and secondary capture for leukocyte accumulation in vivo
    E J Kunkel
    Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville 22908, USA
    Circ Res 82:30-8. 1998
    ..Cluster formation appears to be dominated by areas of endothelium with a higher expression of E-selectin, because cluster formation is greatly reduced in E-selectin-deficient mice...
  43. ncbi Gene-targeted mice reveal importance of L-selectin-dependent rolling for neutrophil adhesion
    U Jung
    Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville 22908, USA
    Am J Physiol 274:H1785-91. 1998
    ..We conclude that L-selectin can mediate rolling that results in sufficient leukocyte recruitment to account for the robust inflammatory response seen in E-/P- mice at later times...
  44. ncbi Overlapping roles for L-selectin and P-selectin in antigen-induced immune responses in the microvasculature
    S Kanwar
    Immunology Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
    J Immunol 162:2709-16. 1999
    ..In conclusion, leukocyte rolling is L-selectin-dependent post-Ag challenge with L-selectin and P-selectin sharing overlapping functions...
  45. ncbi Molecular pathways in bone marrow homing: dominant role of alpha(4)beta(1) over beta(2)-integrins and selectins
    T Papayannopoulou
    Division of Hematology, University of Washington, Seattle 98195 7710, USA
    Blood 98:2403-11. 2001
    ....
  46. ncbi A functional role for circulating mouse L-selectin in regulating leukocyte/endothelial cell interactions in vivo
    LiLi Tu
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 169:2034-43. 2002
    ..These results suggest that sL-selectin influences lymphocyte migration in vivo and that the increased sL-selectin levels present in certain pathologic conditions may adversely affect leukocyte migration...
  47. ncbi Chromosome mapping of Soa, a gene influencing gustatory sensitivity to sucrose octaacetate in mice
    C G Capeless
    Department of Psychology, Florida State University, Tallahassee 32306 1051
    Behav Genet 22:655-63. 1992
    ..The data are consistent with a position for the Soa locus on mouse chromosome 6, 62 cM from the centromere...
  48. ncbi Characterization and chromosomal distribution of endogenous mouse mammary tumor viruses of European mouse strains STS/A and GR/A
    R Michalides
    Virology 142:278-90. 1985
    ..R. Callahan, D. Gallahan, and Ch. Kozak (1984), J. Virol. 49, 1005-1008). GR and GR.Mtv-2 furthermore contain two incomplete MMTV proviral elements, one of which is also present in STS/A...
  49. ncbi Functional analysis of Mel-14+ and Mel-14- early precursor cells in the adult mouse thymus
    L Wu
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Immunol Lett 40:89-92. 1994
    ..This strengthens the hypothesis that one precursor cell has the potential to form all three lineages...
  50. pmc DNA aptamers block L-selectin function in vivo. Inhibition of human lymphocyte trafficking in SCID mice
    B J Hicke
    NeXstar Pharmaceuticals Inc, Boulder, Colorado 80301, USA
    J Clin Invest 98:2688-92. 1996
    ..These aptamers also block L-selectin-dependent lymphocyte trafficking in vivo, indicating their potential utility as therapeutics...
  51. ncbi Leukocyte-endothelial cell interactions - lessons from knockout mice
    A R Rosenkranz
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Exp Nephrol 7:125-36. 1999
    ..Second, we discuss models of experimental glomerulonephritis and what we have learned about leukocyte adhesion receptors in the pathogenesis of glomerulonephritis through studies in knockout mice...
  52. pmc L-selectin can facilitate metastasis to lymph nodes in a transgenic mouse model of carcinogenesis
    F Qian
    Department of Pathology and Developmental Biology, Stanford School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 98:3976-81. 2001
    ....
  53. ncbi The Trypanosoma cruzi membrane mucin AgC10 inhibits T cell activation and IL-2 transcription through L-selectin
    Pilar Alcaide
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, Madrid, 28049 Spain
    Int Immunol 16:1365-75. 2004
    ..AgC10 binds to T cell surface through CD62L, and antibodies to CD62L inhibited T cell proliferation and IL-2 secretion and transcription as efficiently as ..
  54. pmc Suppression of tumor formation in lymph nodes by L-selectin-mediated natural killer cell recruitment
    Shihao Chen
    Glycobiology Program, Cancer Research Center, The Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    J Exp Med 202:1679-89. 2005
    ..These findings indicate that L-selectin-mediated NK cell recruitment plays a crucial role in the control of tumor metastasis into secondary lymphoid organs...
  55. ncbi B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization
    Veronique Angeli
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Immunity 24:203-15. 2006
    ..Knowledge that DC migration from the periphery is augmented by B cell-dependent signals reveals new potential strategies to increase DC migration during vaccination...
  56. ncbi The LFA-1 adhesion molecule is required for protective immunity during pulmonary Mycobacterium tuberculosis infection
    Shamik Ghosh
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 176:4914-22. 2006
    ..Thus, LFA-1 (CD11a/CD18) plays an essential role in immunity to M. tuberculosis infection...
  57. pmc ADAM17 deficiency by mature neutrophils has differential effects on L-selectin shedding
    Ying Li
    Department of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, MN 55108, USA
    Blood 108:2275-9. 2006
    ..Together, our data reveal that L-selectin's surface density on neutrophils is regulated by ADAM17, but homeostatic L-selectin cleavage is not...
  58. doi Monocyte migration to inflamed skin and lymph nodes is differentially controlled by L-selectin and PSGL-1
    Beatriz León
    Departamento de Inmunologia y Oncologia, Centro Nacional de Biotecnologia CSIC, Universidad Autonoma, Madrid, Spain
    Blood 111:3126-30. 2008
    ....
  59. pmc KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors
    Michael A Weinreich
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Immunity 31:122-30. 2009
    ..KLF2 regulates T cell trafficking by promoting expression of the lipid-binding receptor S1P(1) and the selectin CD62L. Recently, it was proposed that KLF2 also represses the expression of chemokine receptors...
  60. pmc TLR-mediated loss of CD62L focuses B cell traffic to the spleen during Salmonella typhimurium infection
    Vicky L Morrison
    School of Biological Sciences, Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom
    J Immunol 185:2737-46. 2010
    ..culture and in mice, MyD88-dependent activation of B cells via TLR2 or TLR9 causes the rapid loss of expression of CD62L by metalloproteinase-dependent shedding...
  61. pmc Inducible costimulator controls migration of T cells to the lungs via down-regulation of CCR7 and CD62L
    Tamson V Moore
    Committee on Immunology and Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Am J Respir Cell Mol Biol 45:843-50. 2011
    ..that activated ICOS(-/-) CD4 T cells express higher concentrations of the lymph node homing receptors, CCR7 and CD62L, than do wild-type CD4 T cells, leading to a preferential return of ICOS(-/-) cells to the nondraining lymph nodes ..
  62. pmc KSGal6ST generates galactose-6-O-sulfate in high endothelial venules but does not contribute to L-selectin-dependent lymphocyte homing
    Michael L Patnode
    Department of Anatomy and Program in Biomedical Sciences, University of California, San Francisco, CA 94143 0452, USA
    Glycobiology 23:381-94. 2013
    ..These results refine our understanding of the biological ligands for L-selectin and introduce a mouse model for investigating the functions of Gal6S in other contexts...
  63. doi ICAM-1 deficiency exacerbates sarcoid-like granulomatosis induced by Propionibacterium acnes through impaired IL-10 production by regulatory T cells
    Masahiro Kamata
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Am J Pathol 183:1731-9. 2013
    ..Our results indicate that ICAM-1 is imperative for inducing regulatory T cells to produce IL-10 in vivo, which would prevent granuloma formation...
  64. pmc The PSGL-1-L-selectin signaling complex regulates neutrophil adhesion under flow
    Anika Stadtmann
    Department of Anesthesiology, Intensive Care, and Pain Medicine and 2 Institute of Medical Biochemistry, Center for Molecular Biology of Inflammation University of Münster, 48149 Munster, Germany
    J Exp Med 210:2171-80. 2013
    ..We conclude that this is a signaling complex specialized for sensing adhesion under flow. ..
  65. doi Protective effects of fucoidan, a P- and L-selectin inhibitor, in murine acute pancreatitis
    Ana C S Carvalho
    From the Departments of Physiology and Pharmacology and Morphology, Institute of Biomedicine of Brazilian Semi arid, School of Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil and NIHR Pancreas Biomedical Research Unit and Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
    Pancreas 43:82-7. 2014
    ..The objective of this study was to investigate the potential protective effects of fucoidan, an L- and P-selectin modulator, in 2 murine models of acute pancreatitis...
  66. ncbi Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivo
    Junko Matsuzaki
    Division of Immunoregulation, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, 060 0815, Hokkaido, Sapporo, Japan
    Cell Immunol 224:98-105. 2003
    ..antigen on various subsets of mouse spleen cells, we found that Gr-1 was expressed on memory-type CD8(+)CD44(high)CD62L(high) T cells in addition to granulocytes...
  67. ncbi L-selectin, alpha 4 beta 1, and alpha 4 beta 7 integrins participate in CD4+ T cell recruitment to chronically inflamed small intestine
    Jesus Rivera-Nieves
    Digestive Health Center of Excellence, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Immunol 174:2343-52. 2005
    ..Thus, pathogenic CD4+ T cells not only use the physiologic alpha4beta7/MAdCAM-1 pathway, but alternatively engage alpha4beta1 and L-selectin to recirculate to the chronically inflamed small intestine...
  68. ncbi Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice
    Yukiyo Matsushita
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Immunol 179:698-707. 2007
    ..Thus, our findings indicate that ICAM-1 expression contributes to the development of skin fibrosis in TSK/+ mice, especially via ICAM-1 expressed on skin fibroblasts...
  69. doi Signals regulating L-selectin-dependent leucocyte adhesion and transmigration
    Aleksandar Ivetic
    Membrane Cytoskeleton Signalling Group, Cardiovascular Division, British Heart Foundation, Centre of Research Excellence, King s College London, London SE5 9NU, United Kingdom
    Int J Biochem Cell Biol 45:550-5. 2013
    ....
  70. ncbi The gene for the ubiquitous octamer-binding protein Oct-1 is on human chromosome 1, region cen-q32, and near Ly-22 and Ltw-4 on mouse chromosome 1
    C L Hsieh
    Howard Hughes Medical Institute, Stanford, California
    Genomics 6:666-72. 1990
    ..There were no recombinants among 26 strains with Ly-22 and 1 recombinant among 24 strains with Ltw-4. The gene symbol is OTF1 for humans and Oct-1 for mouse...
  71. ncbi An alternatively spliced Muc10 glycoprotein ligand for putative L-selectin binding during mouse embryonic submandibular gland morphogenesis
    M Melnick
    Laboratory for Developmental Genetics, University of Southern California, 925 W 34th Street, DEN 4266, CA 90089 0641, Los Angeles, USA
    Arch Oral Biol 46:745-57. 2001
    ..As the primary role of L-selectin is to mediate cell adhesion and its ligands are mucin-like glycoproteins, it is suggested that this embryonic low molecular-weight mucin be termed MucCAM...
  72. ncbi Neonatal infection with a milk-borne virus is independent of beta7 integrin- and L-selectin-expressing lymphocytes
    Jennifer Czarneski
    Department of Microbiology, University of Pennsylvania, Philadelphia, USA
    Eur J Immunol 32:945-56. 2002
    ..These results suggest that adhesion molecules other than beta7 integrin or L-selectin play a role in lymphocyte homing in the gut, peripheral lymph nodes and mammary gland in response to MMTV infection...
  73. ncbi Absence of L-selectin delays mucosal B cell responses in nonintestinal effector tissues
    Keri L Csencsits
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
    J Immunol 169:5649-59. 2002
    ..Yet, these increases in CONALT AFC correlated with restoration of immunity in L-Sel(-/-) nasal passages and reproductive tracts...
  74. pmc Increased primary tumor growth in mice null for beta3- or beta3/beta5-integrins or selectins
    Daniela Taverna
    Howard Hughes Medical Institute, Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 101:763-8. 2004
    ..These results implicate cells of the innate immune system, macrophages or perhaps natural killer cells, in each case dependent on integrins and selectins, in tumor suppression...
  75. ncbi Conservation of IL-6 trans-signaling mechanisms controlling L-selectin adhesion by fever-range thermal stress
    Michelle M Appenheimer
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263 0001, USA
    Eur J Immunol 37:2856-67. 2007
    ....
  76. pmc Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells
    Britt E Anderson
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA
    Blood 111:5242-51. 2008
    ..One potential explanation for the inability of T(EM) to cause GVHD is that T(EM) lack CD62L and CCR7, which are instrumental in directing naive T cells (T(N)) to lymph nodes (LN) and Peyer patches (PP), ..
  77. doi Identification of novel isoforms of mouse L-selectin with different carboxyl-terminal tails
    Yuko Furukawa
    The 21st Century Center of Excellence Program, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565 0871, Japan
    J Biol Chem 283:12112-9. 2008
    ..These results suggest that alternative splicing is one mechanism for generating functional diversity in L-selectin...
  78. pmc Transcriptional regulation of mouse L-selectin
    Xitong Dang
    Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Biochim Biophys Acta 1789:146-52. 2009
    ..Silencing the expression of Sp1 by siRNA significantly decreased sell promoter activity in EL4 cells. We conclude that sell transcription is regulated by Mzf1, Klf2, Sp1, Ets1, and Irf1...
  79. doi Requirement of L-selectin for gammadelta T lymphocyte activation and migration during allergic pleurisy: co-relation with eosinophil accumulation
    Maria Fernanda S Costa
    Laboratório de Farmacologia Aplicada, Departamento de Farmacologia Aplicada, Farmanguinhos, Fundacao Oswaldo Cruz, Rio de Janeiro, Brazil
    Int Immunopharmacol 9:303-12. 2009
    ..Part of these cells expressed CD62L, which increased on gammadelta T cell surfaces obtained from lymph nodes after ovalbumin (OVA) challenge...
  80. pmc Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor
    Yann M Kerdiles
    Molecular Biology Section, Division of Biological Sciences, Department of Cellular and Molecular Medicine, University of California, San Diego, California 92093 0377, USA
    Nat Immunol 10:176-84. 2009
    ..These data suggest that Foxo1 regulates the homeostasis and life span of naive T cells by sensing growth factor availability and regulating homing and survival signals...
  81. doi Differentiation of central memory CD8 T cells is independent of CD62L-mediated trafficking to lymph nodes
    Thomas C Wirth
    Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 182:6195-206. 2009
    b>CD62L (L-selectin) is a key regulator of T cell trafficking, and its surface expression on activated T cells is modulated to control T cell access to lymph nodes after acute infections...
  82. pmc Platelet, not endothelial, P-selectin expression contributes to generation of immunity in cutaneous contact hypersensitivity
    Ralf J Ludwig
    Department of Dermatology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Am J Pathol 176:1339-45. 2010
    ..Our observations indicate that platelet, not endothelial, P-selectin contributes to generation of immunity in DNFB-induced contact hypersensitivity...
  83. pmc Mycolactone impairs T cell homing by suppressing microRNA control of L-selectin expression
    Laure Guenin-Macé
    Institut Pasteur, Unité de Pathogénomique Mycobactérienne Intégrée, 75015 Paris, France
    Proc Natl Acad Sci U S A 108:12833-8. 2011
    ..Our results identify T-cell homing as a biological process targeted by mycolactone. Moreover, they reveal a mechanism of control of CD62-L expression involving the miRNA let-7b...
  84. ncbi Construction of a physical map on mouse and human chromosome 1: comparison of 13 Mb of mouse and 11 Mb of human DNA
    R J Oakey
    Department of Medicine, Duke University Medical Center, Durham, NC 27710
    Hum Mol Genet 1:613-20. 1992
    ..These data support the use of comparative mapping in physical map construction and further suggest the value of using mouse genetics to help define human disease loci...
  85. ncbi Genetic linkage analysis in recombinant inbred mice of P40, a putative clone for the high-affinity laminin receptor
    P J Douville
    Centre for Research in Neurosciences, Montreal General Hospital, Quebec, Canada
    Mamm Genome 3:438-46. 1992
    ..These P40 loci comprise part of a multimember gene family that is well dispersed in the mouse genome...
  86. ncbi Characterization of the murine homing receptor gene reveals correspondence between protein domains and coding exons
    D J Dowbenko
    Department of Immunobiology, Genentech, Inc, South San Francisco, California 94080
    Genomics 9:270-7. 1991
    ....
  87. ncbi Cloning of a lymphocyte homing receptor reveals a lectin domain
    L A Lasky
    Department of Cardiovascular Research, Genentech, Inc South San Francisco, California 94080
    Cell 56:1045-55. 1989
    ..This result supports a novel mechanism for the distribution of lymphocyte populations to various lymphoid organs...
  88. ncbi Genetic relationships of Mlsa among polymorphic loci on distal mouse chromosome 1
    M F Seldin
    Department of Medicine, Duke University Medical Center, Durham, NC 27710
    J Immunogenet 15:59-66. 1988
    ..The identification of multiple polymorphic loci in the region of Mlsa should allow precise gene localization and assist in efforts to clone this gene...
  89. pmc Endogenous xenotropic murine leukemia virus-related sequences map to chromosomal regions encoding mouse lymphocyte antigens
    J C Wejman
    J Virol 50:237-47. 1984
    ..These studies indicate that xenotropic proviral loci are located on many different mouse chromosomes and may be useful markers for molecularly cloning and characterizing regions of the mouse genome important in lymphocyte development...
  90. ncbi Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-deficient colitis
    S J Simpson
    Division of Immunology Beth Israel Hospital, Harvard Medical School, Boston, MA 02215, USA
    Eur J Immunol 25:2618-25. 1995
    ..In light of these findings, we propose that infiltrating CD4+, but not CD8+ T cells are central to the inflammation observed in the intestinal mucosa in IL-2null colitis...
  91. ncbi Mapping of the gene for high-density lipoprotein binding protein (Hdlbp) to proximal mouse chromosome 1
    R C LeBoeuf
    Department of Medicine, University of Washington, Seattle 98195
    Genomics 23:296-8. 1994
  92. ncbi Endogenous nonecotropic proviruses mapped with oligonucleotide probes from the long terminal repeat region
    W N Frankel
    Jackson Laboratory, Bar Harbor, Maine 04609
    Mamm Genome 5:275-81. 1994
    ..Together with proviruses identified previously with env probes, the LTR probe-reactive elements represent the majority of endogenous murine leukemia proviruses in the mouse genome...
  93. ncbi Cloning of the cDNA for rabbit L-selectin and expression of recombinant protein with a kinase target site to facilitate radiolabeling
    J Qian
    Department of Internal Medicine, University of Michigan, Ann Arbor 48109 0531, USA
    Biochem Biophys Res Commun 225:406-12. 1996
    ..Amino-terminal peptide sequencing of recombinant L-Selectin confirmed that the signal peptide had been removed at the expected site...
  94. pmc Neutrophil margination, sequestration, and emigration in the lungs of L-selectin-deficient mice
    N A Doyle
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Clin Invest 99:526-33. 1997
    ..coli-induced pneumonia, and in the accumulation of neutrophils within noncapillary microvessels when induced by either intravascular complement fragments or..
  95. ncbi The value of gene 'knock-out' for assessing the role of cell adhesion molecules in renal disease
    A McGinty
    Department of Medicine and Therapeutics, Mater Misericordiae Hospital, University College Dublin, Ireland
    Nephrol Dial Transplant 14:27-9. 1999
  96. pmc Mobilization of stem/progenitor cells by sulfated polysaccharides does not require selectin presence
    E A Sweeney
    Department of Medicine, Division of Hematology, University of Washington, Seattle, WA 98195 7710, USA
    Proc Natl Acad Sci U S A 97:6544-9. 2000
    ..As similarly sulfated compounds were ineffective in vivo, the data also underscore the fact that polysaccharides with similar structures may elicit diverse in vivo effects...
  97. ncbi Role of selectins in experimental Staphylococcus aureus-induced arthritis
    M Verdrengh
    Department of Rheumatology, University of Goteborg, Sweden
    Eur J Immunol 30:1606-13. 2000
    ..aureus-induced arthritis: on the one hand, blockade of these selectins leads to less severe arthritic lesions in the initial stage of the disease; on the other, delayed recruitment of phagocytes decreases the clearance of bacteria...
  98. ncbi Pathophysiologic importance of E- and L-selectin for neutrophil-induced liver injury during endotoxemia in mice
    J A Lawson
    Department of Pharmacology, Pharmacia and Upjohn, Inc, Kalamazoo, MI, USA
    Hepatology 32:990-8. 2000
    ..Therefore, we conclude that blocking E-selectin or eliminating this gene may have protected against Gal/ET-induced liver injury in vivo by inhibiting the full activation of neutrophils during the transmigration process...
  99. ncbi Impaired mucosal immunity in L-selectin-deficient mice orally immunized with a Salmonella vaccine vector
    D W Pascual
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
    J Immunol 167:407-15. 2001
    ..This evidence shows that L-Sel is important for development of mucosal immunity, and absence of L-Sel is protective against salmonellosis...
  100. ncbi Dermal and pulmonary inflammatory disease in E-selectin and P-selectin double-null mice is reduced in triple-selectin-null mice
    R G Collins
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Blood 98:727-35. 2001
    ..The occurrence of skin and pulmonary disease in E/P double-mutant mice but not E/L/P triple-mutant mice suggests that deficiency of L-selectin alters the inflammatory response in E/P mutants. (Blood. 2001;98:727-735)..
  101. ncbi Cutting edge: dichotomy of homing receptor dependence by mucosal effector B cells: alpha(E) versus L-selectin
    K L Csencsits
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
    J Immunol 167:2441-5. 2001
    ..This study provides evidence for compartmentalization of the common mucosal immune system into "intestinal" vs "nonintestinal" effector sites...

Research Grants18

  1. Structure/Functional Characterization of vWF-A1 Domain
    THOMAS DIACOVO; Fiscal Year: 2007
    ..Information from these studies may aid in the design of antithrombotics with specific kinetic properties that can compete with the native-ligand pair. ..
  2. Novel Dendritic Cell Chemoattractant and Receptor
    Eugene Butcher; Fiscal Year: 2009
    ..abstract_text> ..
  3. Mucosal Therapy for Autoimmunity
    David Pascual; Fiscal Year: 2008
    ..Studies in Specific Aim 3 will determine the responsible dendritic cell subset that supports regulatory T cell development. ..
  4. MUCOSAL TRANSGENE VACCINATION FOR HIV
    David Pascual; Fiscal Year: 2003
    ..These studies will provide the basis for future development of subunit vaccines to target the NALT for eliciting protective immunity via the common mucosal immune system. ..
  5. TARGETED DNA DELIVERY FOR SALIVARY IGA RESPONSES
    David Pascual; Fiscal Year: 2004
    ..These studies will provide the basis for future development of subunit vaccines to target the NALT for eliciting protective immunity in the oral cavity and SALT. ..
  6. Mucosal Vaccines for Plague
    David Pascual; Fiscal Year: 2006
    ..pestis challenge. From these studies, we will produce efficacious vaccines to plague, as well as a supporting vaccine regimen, that will confer protective immunity in the mucosal and systemic immune compartments. ..
  7. MUCOSAL IMMUNITY ELICITED BY SALMONELLA VACCINE DELIVERY
    David Pascual; Fiscal Year: 2009
    ..Thus, from these studies we will learn the specific mechanisms induced by this anti-inflammatory vaccine. ..
  8. Mucosal Lymphocyte Homing in the Head and Neck
    David Pascual; Fiscal Year: 2008
    ..n. challenge with CT. From this work, we will learn how routes of immunizations can be used to effectively target vaccines to nonintestinal mucosal sites. ..
  9. GLOBIN SWITCHING AND ERYTHROID DIFFERENTIATION
    Thalia Papayannopoulou; Fiscal Year: 2002
    ....
  10. Tolerogenic DC as Therapeutic Agents in GVHD
    Eugene C Butcher; Fiscal Year: 2010
    ..Together, these studies will define in detail the potential of CCR9+ pDCs to suppress deleterious effects of GVHD in settings modeling situations in which human patients encounter pathogenic GVHD responses. ..
  11. Intestinal Lymphocyte Trafficking
    Eugene Butcher; Fiscal Year: 2009
    ....
  12. P13Kdelta Modulation of Neutrophil Trafficking
    THOMAS DIACOVO; Fiscal Year: 2008
    ..Moreover, our results will define a new role for class I PBKs, regulation of the adhesive properties of inflamed endothelium. ..
  13. ENDOTHELIAL CELL BIOLOGY IN INFLAMMATION
    Eugene Butcher; Fiscal Year: 2008
    ..The proposed studies should expand our understanding of the critical role of the vascular endothelium in regulating lymphocyte trafficking during normal and pathologic immune responses. ..
  14. VASCULAR-MONOCYTE ADHESION MOLECULE IN ATHEROGENESIS
    Eugene Butcher; Fiscal Year: 2002
    ..The proposed studies will elucidate the structure of this novel vascular receptor and its role in monocyte recruitment in atherogenesis. They may lead to new approaches to the regulation of the atherogenic process. ..
  15. CHEMOATTRACTANT SIGNALING TO LEUKOCYTE INTEGRINS
    Eugene Butcher; Fiscal Year: 2001
    ..These studies should define signaling mechanisms regulating the adhesion of leukocytes and other cells, and may lead to novel therapeutic approaches for the control of neoplastic and inflammatory diseases ..
  16. Investigation of Nod2: Implications for Uveitis
    Holly Rosenzweig; Fiscal Year: 2008
    ..Together, these studies will provide valuable new information on how Nod2 is involved in autoimmunity and the pathogeneis of uveitis. ..
  17. BIOLOGICAL PROPERTIES AND REGULATION OF STEM CELLS
    Thalia Papayannopoulou; Fiscal Year: 2009
    ..We believe that the proposed studies will enhance our understanding and provide a more comprehensive picture of the influence of <x4 integrins on prenatal and postnatal hematopoiesis. ..
  18. Conference on Leukocyte Trafficking
    Eugene Butcher; Fiscal Year: 2004
    ..abstract_text> ..