Krt16

Summary

Gene Symbol: Krt16
Description: keratin 16
Alias: AI324768, CK-16, K16, Krt1-16, keratin, type I cytoskeletal 16, cytokeratin-16, keratin complex 1, acidic, gene 16, keratin intermediate filament 16a, keratin intermediate filament 16b
Species: mouse

Top Publications

  1. ncbi cDNA cloning, expression, and assembly characteristics of mouse keratin 16
    R M Porter
    Cancer Research Campaign Cell Structure Research Group, Department of Anatomy and Physiology, Medical Sciences Institute Wellcome Trust Building Complex, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom
    J Biol Chem 273:32265-72. 1998
  2. ncbi Keratin 16 expression defines a subset of epithelial cells during skin morphogenesis and the hair cycle
    Kelsie M Bernot
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Invest Dermatol 119:1137-49. 2002
  3. pmc Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation
    A Stoler
    Department of Molecular Genetics, University of Chicago, Illinois 60637
    J Cell Biol 107:427-46. 1988
  4. pmc The functional diversity of epidermal keratins revealed by the partial rescue of the keratin 14 null phenotype by keratin 16
    R D Paladini
    Departments of Biological Chemistry and Dermatology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Cell Biol 146:1185-201. 1999
  5. pmc Structural and biochemical changes underlying a keratoderma-like phenotype in mice lacking suprabasal AP1 transcription factor function
    E A Rorke
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA
    Cell Death Dis 6:e1647. 2015
  6. pmc Three-dimensional model of mouse epidermis for experimental studies of psoriasis
    A G Soboleva
    Federal Non profit Research Institute of Russian Academy of Sciences, N I Vavilov Institute of General Genetics, Moscow 119991, Russia
    Acta Naturae 5:110-7. 2013
  7. pmc Keratin 16 regulates innate immunity in response to epidermal barrier breach
    Juliane C Lessard
    Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205
    Proc Natl Acad Sci U S A 110:19537-42. 2013
  8. pmc Forced expression of keratin 16 alters the adhesion, differentiation, and migration of mouse skin keratinocytes
    M Wawersik
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Biol Cell 11:3315-27. 2000
  9. pmc Keratin 16-null mice develop palmoplantar keratoderma, a hallmark feature of pachyonychia congenita and related disorders
    Juliane C Lessard
    Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Invest Dermatol 132:1384-91. 2012
  10. pmc Barx2 functions through distinct corepressor classes to regulate hair follicle remodeling
    Lorin E Olson
    Howard Hughes Medical Institute, Biomedical Sciences Graduate Program, University of California at San Diego School of Medicine, La Jolla, CA 92093 0648, USA
    Proc Natl Acad Sci U S A 102:3708-13. 2005

Scientific Experts

  • Tomohiko Sano
  • R M Porter
  • M A Montenegro
  • Pierre A Coulombe
  • Juliane C Lessard
  • Kelsie M Bernot
  • E A Rorke
  • A G Soboleva
  • Xuemei Tong
  • Lorin E Olson
  • Jiang Chen
  • M Blumenberg
  • R H Rice
  • Stacy Mazzalupo
  • P M Elias
  • J Meyer
  • R L Eckert
  • G Adhikary
  • D Crumrine
  • C A Young
  • Jeremy D Rotty
  • Allan Balmain
  • V V Sobolev
  • S A Bruskin
  • Robyn P Hickerson
  • A V Mezentsev
  • Sylvia PiƱa-Paz
  • Roger L Kaspar
  • M Wawersik
  • P A Coulombe
  • H HogenEsch
  • D Talbot
  • R D Paladini
  • David W Rose
  • Havilah Taylor
  • Jie Zhang
  • Chang Hun Lee
  • Dennis R Roop
  • Michael G Rosenfeld
  • Pauline Wong
  • Paul Martin
  • Kevin M McGowan
  • J Loring
  • J Lorgin
  • D Boggess
  • H Schorle
  • J P Sundberg
  • A Heyden
  • C K Jiang
  • O P Clausen
  • H S Huitfeldt
  • P Brandtzaeg
  • C Lutzow-Holm
  • F Bernerd
  • M Ohtsuki
  • T Magnaldo
  • I M Freedberg
  • A Stoler
  • P M Steinert
  • A C Steven
  • D R Roop
  • B L Trus
  • E Fuchs
  • M Duvic
  • R Kopan

Detail Information

Publications23

  1. ncbi cDNA cloning, expression, and assembly characteristics of mouse keratin 16
    R M Porter
    Cancer Research Campaign Cell Structure Research Group, Department of Anatomy and Physiology, Medical Sciences Institute Wellcome Trust Building Complex, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom
    J Biol Chem 273:32265-72. 1998
    There has been speculation as to the existence of the mouse equivalent of human type I keratin 16 (K16)...
  2. ncbi Keratin 16 expression defines a subset of epithelial cells during skin morphogenesis and the hair cycle
    Kelsie M Bernot
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Invest Dermatol 119:1137-49. 2002
    ....
  3. pmc Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation
    A Stoler
    Department of Molecular Genetics, University of Chicago, Illinois 60637
    J Cell Biol 107:427-46. 1988
    ..antisera, each of which is specific for a single keratin from one of the three different pairs (K1/K10, K14/K5, K16/K6) that are differentially expressed in normal human epidermis and in epidermal diseases of hyperproliferation...
  4. pmc The functional diversity of epidermal keratins revealed by the partial rescue of the keratin 14 null phenotype by keratin 16
    R D Paladini
    Departments of Biological Chemistry and Dermatology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Cell Biol 146:1185-201. 1999
    The type I epidermal keratins K14 and K16 are remarkably similar at the primary sequence level...
  5. pmc Structural and biochemical changes underlying a keratoderma-like phenotype in mice lacking suprabasal AP1 transcription factor function
    E A Rorke
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA
    Cell Death Dis 6:e1647. 2015
    ..and Krt10) is reduced, but incorporation of hyperproliferation-associated epidermal keratins (Krt6a, Krt6b and Krt16) is increased...
  6. pmc Three-dimensional model of mouse epidermis for experimental studies of psoriasis
    A G Soboleva
    Federal Non profit Research Institute of Russian Academy of Sciences, N I Vavilov Institute of General Genetics, Moscow 119991, Russia
    Acta Naturae 5:110-7. 2013
    ..The observed changes in gene expression of metalloproteinases and certain psoriasis biomarkers, such as mki67, krt16 and fosl1, were similar to the changes in patients' skin...
  7. pmc Keratin 16 regulates innate immunity in response to epidermal barrier breach
    Juliane C Lessard
    Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205
    Proc Natl Acad Sci U S A 110:19537-42. 2013
    Mutations in the type I keratin 16 (Krt16) and its partner type II keratin 6 (Krt6a, Krt6b) cause pachyonychia congenita (PC), a disorder typified by dystrophic nails, painful hyperkeratotic calluses in glabrous skin, and lesions ..
  8. pmc Forced expression of keratin 16 alters the adhesion, differentiation, and migration of mouse skin keratinocytes
    M Wawersik
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Biol Cell 11:3315-27. 2000
    Injury to the skin results in an induction of keratins K6, K16, and K17 concomitant with activation of keratinocytes for reepithelialization...
  9. pmc Keratin 16-null mice develop palmoplantar keratoderma, a hallmark feature of pachyonychia congenita and related disorders
    Juliane C Lessard
    Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Invest Dermatol 132:1384-91. 2012
    Keratin 16 (KRT16 in human, Krt16 in mouse), a type I intermediate filament protein, is constitutively expressed in epithelial appendages and is induced in the epidermis upon wounding and other stressors...
  10. pmc Barx2 functions through distinct corepressor classes to regulate hair follicle remodeling
    Lorin E Olson
    Howard Hughes Medical Institute, Biomedical Sciences Graduate Program, University of California at San Diego School of Medicine, La Jolla, CA 92093 0648, USA
    Proc Natl Acad Sci U S A 102:3708-13. 2005
    ..Together, our data suggest that the hair-remodeling defect of Barx2 mutant mice could be explained, in part, by failure to repress one or more critical target genes...
  11. ncbi Role for keratins 6 and 17 during wound closure in embryonic mouse skin
    Stacy Mazzalupo
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Dev Dyn 226:356-65. 2003
    ..response is a rapid switch in gene expression whereby the type II keratin 6 (K6) and type I keratins 16 and 17 (K16, K17) are induced in epithelial cells at the wound edge...
  12. doi Long-term alteration in the expression of keratins 6 and 16 in the epidermis of mice after chronic UVB exposure
    Tomohiko Sano
    Beauty Care Research Center, Kao Corporation, 2 1 3 Bunka Sumidaku, Tokyo, Japan
    Arch Dermatol Res 301:227-37. 2009
    ..skin of chronic exposure to weak UVB (below 1 MED) was examined by immunoblotting for keratins K10, K5, K6, and K16, by immunohistochemistry using antibodies to K6, K16, and Ki67 as well as by conventional HE staining of skin ..
  13. pmc Keratin 17 modulates hair follicle cycling in a TNFalpha-dependent fashion
    Xuemei Tong
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Genes Dev 20:1353-64. 2006
    ..These findings identify K17 and TNFalpha as two novel and interdependent regulators of hair cycling...
  14. ncbi Mouse models in preclinical studies for pachyonychia congenita
    Jiang Chen
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Investig Dermatol Symp Proc 10:37-46. 2005
    ..Here, we review the existing mouse models involving the keratin genes (K6a, K6b, K16, and K17) that cause the human genetic disorder pachyonychia congenita (PC)...
  15. pmc A small surface hydrophobic stripe in the coiled-coil domain of type I keratins mediates tetramer stability
    Kelsie M Bernot
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Cell Biol 168:965-74. 2005
    ..The inability of K16 to form urea-stable tetramers in vitro correlates with an increase in its turnover rate in vivo...
  16. ncbi Cytokeratin, vimentin and E-cadherin immunodetection in the embryonic palate in two strains of mice with different susceptibility to glucocorticoid-induced clefting
    M A Montenegro
    Department of Morphology, Biomedical Ciencies Institute, Faculty of Medicine, University of Chile
    J Craniofac Genet Dev Biol 20:137-43. 2000
    ..These results may be related to the loss of cytokeratin expression observed during epithelial-mesenchymal transformation in the embryonic palate...
  17. ncbi Spatiotemporal expression pattern of keratins in skin of AP-2alpha-deficient mice
    D Talbot
    Forschungszentrum Karlsruhe, Institute for Toxicology and Genetics, Eggenstein Leopoldshafen, Germany
    J Invest Dermatol 113:816-20. 1999
    ..Furthermore, the mutants lack a ring of ectodermal cells highly positive for keratin 15 in the area where lens induction occurs, indicating a defect in the inductive interactions underlying eye formation...
  18. ncbi Changes in keratin and filaggrin expression in the skin of chronic proliferative dermatitis (cpdm) mutant mice
    H HogenEsch
    Department of Veterinary Pathobiology, Purdue University, West Lafayette, Ind 47907 1243, USA
    Pathobiology 67:45-50. 1999
    ..These results indicate that the differentiation of keratinocytes in cpdm/cpdm mice was normal. The altered distribution and expression of keratins in comparison with the skin of control mice was the result of hyperproliferation...
  19. pmc Epidermal growth factor and transforming growth factor alpha specifically induce the activation- and hyperproliferation-associated keratins 6 and 16
    C K Jiang
    Ronald O Perelman Department of Dermatology, New York University Medical Center, NY 10016
    Proc Natl Acad Sci U S A 90:6786-90. 1993
    ..Activated keratinocytes express a specific pair of keratin proteins, K6 and K16, distinct from the keratins in the healthy epidermis...
  20. ncbi Expression of keratins K6 and K16 in regenerating mouse epidermis is less restricted by cell replication than the expression of K1 and K10
    A Heyden
    Laboratory of Immunohistochemistry and Immunopathology LIIPAT, National Hospital, Oslo, Norway
    Epithelial Cell Biol 3:96-101. 1994
    Biosynthesis of the hyperproliferation-associated keratins K6 and K16 was studied in mouse epidermis following a single topical application of the tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA)...
  21. ncbi Complete amino acid sequence of a mouse epidermal keratin subunit and implications for the structure of intermediate filaments
    P M Steinert
    Nature 302:794-800. 1983
    ....