Klk5

Summary

Gene Symbol: Klk5
Description: kallikrein related-peptidase 5
Alias: 1110030O19Rik, kallikrein-5, kallikrein 5
Species: mouse

Top Publications

  1. ncbi Human tissue kallikreins: physiologic roles and applications in cancer
    Carla A Borgono
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5 Canada
    Mol Cancer Res 2:257-80. 2004
  2. ncbi Differences in Kallikrein-related peptidase mRNA sequences and KLK6 enzyme activity between mouse strains
    Koichi Murakami
    Department of Functional Anatomy and Neuroscience, Asahikawa Medical University, 2 1 1 1 Midorigaoka Higashi, Asahikawa 078 8510, Japan
    Protein Pept Lett 22:204-11. 2014
  3. pmc KLK5 Inactivation Reverses Cutaneous Hallmarks of Netherton Syndrome
    Laetitia Furio
    INSERM UMR 1163, Laboratory of Genetic Skin Diseases, Imagine Institute, Paris, France University Paris Descartes Sorbonne Paris Cité, Paris, France
    PLoS Genet 11:e1005389. 2015
  4. pmc KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-like Phenotype
    Petr Kaspárek
    Laboratory of Transgenic Models of Diseases, Division BIOCEV, Institute of Molecular Genetics of the ASCR, Vestec, Czech Republic
    PLoS Genet 13:e1006566. 2017
  5. ncbi Characterization of mouse tissue kallikrein 5
    Sanath Rajapakse
    Laboratory of Molecular and Cellular Interactions, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan
    Zoolog Sci 23:963-8. 2006
  6. pmc Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development
    Kristopher R Schwab
    Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    BMC Biol 5:15. 2007
  7. pmc Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors
    Ashleigh E Schaffer
    Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA
    Dev Cell 18:1022-9. 2010
  8. ncbi Organization and evolution of the glandular kallikrein locus in Mus musculus
    A Yvonne Olsson
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, University Hospital MAS, Malmo, Sweden
    Biochem Biophys Res Commun 299:305-11. 2002

Scientific Experts

  • Koichi Murakami
  • Kristopher R Schwab
  • A Yvonne Olsson
  • Petr Kaspárek
  • Laetitia Furio
  • Ashleigh E Schaffer
  • Iacovos P Michael
  • Sanath Rajapakse
  • Carla A Borgono
  • Olga Zbodakova
  • Karel Chalupsky
  • Maria Brattsand
  • Zuzana Ileninova
  • Inken M Beck
  • Oldrich Benada
  • Ivan Kanchev
  • Radislav Sedlacek
  • Andras Nagy
  • Georgios Pampalakis
  • Alain Hovnanian
  • Georgia Sotiropoulou
  • Kristine K Freude
  • Shelley B Nelson
  • Maike Sander
  • Sumio Takahashi
  • Noriko Yamano
  • Kensaku Hirata
  • Takayuki Takahashi
  • Katsueki Ogiwara
  • Atsushi Kimura
  • Eleftherios P Diamandis

Detail Information

Publications9

  1. ncbi Human tissue kallikreins: physiologic roles and applications in cancer
    Carla A Borgono
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5 Canada
    Mol Cancer Res 2:257-80. 2004
    ..Recent data also suggest that hKs may be causally involved in carcinogenesis, particularly in tumor metastasis and invasion, and, thus, may represent attractive drug targets to consider for therapeutic intervention...
  2. ncbi Differences in Kallikrein-related peptidase mRNA sequences and KLK6 enzyme activity between mouse strains
    Koichi Murakami
    Department of Functional Anatomy and Neuroscience, Asahikawa Medical University, 2 1 1 1 Midorigaoka Higashi, Asahikawa 078 8510, Japan
    Protein Pept Lett 22:204-11. 2014
    ..These results suggest that KLKs may contribute to the genetic basis of the differences between mouse strains. ..
  3. pmc KLK5 Inactivation Reverses Cutaneous Hallmarks of Netherton Syndrome
    Laetitia Furio
    INSERM UMR 1163, Laboratory of Genetic Skin Diseases, Imagine Institute, Paris, France University Paris Descartes Sorbonne Paris Cité, Paris, France
    PLoS Genet 11:e1005389. 2015
    ..Spink5⁻/⁻ mice recapitulate the NS phenotype, display enhanced epidermal Klk5 and Klk7 protease activities and die within a few hours after birth because of a severe skin barrier defect...
  4. pmc KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton Syndrome-like Phenotype
    Petr Kaspárek
    Laboratory of Transgenic Models of Diseases, Division BIOCEV, Institute of Molecular Genetics of the ASCR, Vestec, Czech Republic
    PLoS Genet 13:e1006566. 2017
    ..b>KLK5 was proposed as a major protease in NS pathology, however its inactivation is not sufficient to rescue the lethal ..
  5. ncbi Characterization of mouse tissue kallikrein 5
    Sanath Rajapakse
    Laboratory of Molecular and Cellular Interactions, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan
    Zoolog Sci 23:963-8. 2006
    ..Mouse tissue kallikrein 5 (Klk5) has long been thought to be one of these functional genes, but the gene product, mK5, has not been ..
  6. pmc Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development
    Kristopher R Schwab
    Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    BMC Biol 5:15. 2007
    ..To better understand the functions of Pygopus-mediated canonical Wnt signaling in kidney development, targeted mutations were made in the two mammalian orthologs, Pygo1 and Pygo2...
  7. pmc Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors
    Ashleigh E Schaffer
    Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA
    Dev Cell 18:1022-9. 2010
    ..Thus, cross-antagonism between Nkx6 and Ptf1a in multipotent progenitors governs the equilibrium between endocrine and acinar cell neogenesis required for normal pancreas development...
  8. ncbi Organization and evolution of the glandular kallikrein locus in Mus musculus
    A Yvonne Olsson
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, University Hospital MAS, Malmo, Sweden
    Biochem Biophys Res Commun 299:305-11. 2002
    ..Phylogenetic analyses show that classical GK genes emerged after the separation of the primate and rodent lineages, forming a subgroup within the newly extended GK family...