Klf4

Summary

Gene Symbol: Klf4
Description: Kruppel-like factor 4 (gut)
Alias: EZF, Gklf, Zie, Krueppel-like factor 4, Kruppel-like factor 4 (Gut enriched kruppel-like factor) (Epithelial zinc-finger protein EZF), epithelial zinc finger protein EZF, gut-enriched krueppel-like factor
Species: mouse

Top Publications

  1. doi Induced pluripotent stem cells expressing elevated levels of sox-2, oct-4, and klf-4 are severely reduced in their differentiation from mesodermal to hematopoietic progenitor cells
    Katharina Seiler
    Senior Research Group Lymphocyte Development, Max Planck Institute for Infection Biology, Berlin, Germany
    Stem Cells Dev 20:1131-42. 2011
  2. pmc Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrest
    J M Shields
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 271:20009-17. 1996
  3. ncbi A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells
    L A Garrett-Sinha
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 271:31384-90. 1996
  4. ncbi Human EZF, a Krüppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains
    S F Yet
    Cardiovascular Biology Laboratory, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Biol Chem 273:1026-31. 1998
  5. pmc Expression of the gut-enriched Krüppel-like factor gene during development and intestinal tumorigenesis
    H Ton-That
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    FEBS Lett 419:239-43. 1997
  6. pmc Identification of the DNA sequence that interacts with the gut-enriched Krüppel-like factor
    J M Shields
    Department of Medicine and Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Nucleic Acids Res 26:796-802. 1998
  7. pmc The gut-enriched Krüppel-like factor suppresses the activity of the CYP1A1 promoter in an Sp1-dependent fashion
    W Zhang
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 273:17917-25. 1998
  8. ncbi GKLF in thymus epithelium as a developmentally regulated element of thymocyte-stroma cross-talk
    M Panigada
    Department of Biological and Technological Research DIBIT, San Raffaele Scientific Institute HSR, Milan, Italy
    Mech Dev 81:103-13. 1999
  9. ncbi Klf4 is a transcription factor required for establishing the barrier function of the skin
    J A Segre
    Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, The University of Chicago, Illinois 60637, USA
    Nat Genet 22:356-60. 1999
  10. pmc Characterization of the structure and regulation of the murine gene encoding gut-enriched Krüppel-like factor (Krüppel-like factor 4)
    C S Mahatan
    Department of Medicine, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Nucleic Acids Res 27:4562-9. 1999

Research Grants

Scientific Experts

  • Shivalingappa K Swamynathan
  • Mark Feinberg
  • Changchang Liu
  • Ken Nishimura
  • Chang Su
  • Joyce Lloyd
  • Ryan F L O'Shaughnessy
  • Tadashi Yoshida
  • Peilin Zhang
  • Shanshan Zhu
  • Juan P Liuzzi
  • Trevor L Cameron
  • Galih Kunarso
  • Julie Segre
  • Pablo Navarro
  • Vincent W Yang
  • Amr M Ghaleb
  • Klaus H Kaestner
  • Jonathan P Katz
  • Junwen Liu
  • Ying Liu
  • V W Yang
  • Guangjin Zhou
  • Nikunj Sharma
  • Xudong Liao
  • Song Qin
  • Hong S Yoon
  • Mukesh K Jain
  • Mandayam O Nandan
  • Dong Wook Han
  • Anne Hamik
  • Beth B McConnell
  • Huali Zhang
  • XianZhong Xiao
  • J M Shields
  • Maren Godmann
  • Qiang Li
  • Yuan Lu
  • Xi Chen
  • Walden Ai
  • Hai Zheng
  • Gang Liu
  • Jettanong Klaewsongkram
  • Xinming Chen
  • Isharat Yusuf
  • A M Ghaleb
  • Michael G Kharas
  • Meidong Liu
  • Yuhki Nakatake
  • Neha Tiwari
  • Katrin Kierdorf
  • Erika M Whitney
  • Tianxin Yu
  • Ze Shiang Lin
  • Ikumi Michikami
  • Katrin Hoffmeyer
  • Céline Vivien
  • Ganapati H Mahabeleshwar
  • Chun Li Zhang
  • Keping Xie
  • K H Kaestner
  • Xiangdong Le
  • Qi Li
  • Xiangyu Kong
  • Carlos Pérez-Monter
  • Dawei Li
  • Katharina Seiler
  • James Harper
  • Anja Schuetz
  • Luca Pellegrinet
  • Wen Zhang
  • Jie An
  • Jennifer L Yori
  • Clifford D L Folmes
  • Marcos J Arauzo-Bravo
  • Martin Stehling
  • Hans R Scholer
  • Christof Bernemann
  • Natalia Tapia
  • Guangming Wu
  • Boris Greber
  • Kinarm Ko
  • Shih Han Lee
  • Colleen E Cowan
  • Marie Pier Tetreault
  • Kalyan Srivastava
  • Lori Lebson
  • Paul M Evans
  • Akira Nishiyama
  • Marta Moral

Detail Information

Publications114 found, 100 shown here

  1. doi Induced pluripotent stem cells expressing elevated levels of sox-2, oct-4, and klf-4 are severely reduced in their differentiation from mesodermal to hematopoietic progenitor cells
    Katharina Seiler
    Senior Research Group Lymphocyte Development, Max Planck Institute for Infection Biology, Berlin, Germany
    Stem Cells Dev 20:1131-42. 2011
    ..These results suggest that iPS cell generation with the aim of developing hematopoietic cells should be controlled and selected for low levels of transduced Sox-2, Oct-4, and Kfl-4 expression...
  2. pmc Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrest
    J M Shields
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 271:20009-17. 1996
    A cDNA clone, named gut-enriched Krüppel-like factor (GKLF), was isolated from an NIH 3T3 library using a probe encoding the zinc finger region of the immediate-early transcription factor zif/268...
  3. ncbi A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells
    L A Garrett-Sinha
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 271:31384-90. 1996
    ..The chromosomal location of the gene was mapped using mouse interspecific backcrosses and was shown to localize to mouse chromosome 4 and to cosegregate with the thioredoxin gene...
  4. ncbi Human EZF, a Krüppel-like zinc finger protein, is expressed in vascular endothelial cells and contains transcriptional activation and repression domains
    S F Yet
    Cardiovascular Biology Laboratory, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Biol Chem 273:1026-31. 1998
    ..Sequence analysis indicated that our clone, hEZF, is the human homologue of the recently reported mouse EZF and GKLF. hEZF is a single-copy gene that maps to chromosome 9q31...
  5. pmc Expression of the gut-enriched Krüppel-like factor gene during development and intestinal tumorigenesis
    H Ton-That
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    FEBS Lett 419:239-43. 1997
    We examined the expression of GKLF (gut-enriched Krüppel-like factor), a recently identified zinc finger-containing transcription factor, in mice during development using the ribonuclease protection assay...
  6. pmc Identification of the DNA sequence that interacts with the gut-enriched Krüppel-like factor
    J M Shields
    Department of Medicine and Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Nucleic Acids Res 26:796-802. 1998
    The gut-enriched Krüppel-like factor (GKLF) is a recently identified eukaryotic transcription factor that contains three C2H2zinc fingers...
  7. pmc The gut-enriched Krüppel-like factor suppresses the activity of the CYP1A1 promoter in an Sp1-dependent fashion
    W Zhang
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 273:17917-25. 1998
    The gut-enriched Krüppel-like factor (GKLF) is a newly identified zinc finger-containing transcription factor...
  8. ncbi GKLF in thymus epithelium as a developmentally regulated element of thymocyte-stroma cross-talk
    M Panigada
    Department of Biological and Technological Research DIBIT, San Raffaele Scientific Institute HSR, Milan, Italy
    Mech Dev 81:103-13. 1999
    Gut-enriched Krüppel-like factor (GKLF) is a transcriptional regulator expressed in differentiated epithelia...
  9. ncbi Klf4 is a transcription factor required for establishing the barrier function of the skin
    J A Segre
    Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, The University of Chicago, Illinois 60637, USA
    Nat Genet 22:356-60. 1999
    ..We show here that Kruppel-like factor 4 (Klf4, encoded by the gene Klf4), highly expressed in the differentiating layers of epidermis, is both vital to and ..
  10. pmc Characterization of the structure and regulation of the murine gene encoding gut-enriched Krüppel-like factor (Krüppel-like factor 4)
    C S Mahatan
    Department of Medicine, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    Nucleic Acids Res 27:4562-9. 1999
    Gut-enriched Krüppel-like factor (GKLF, KLF4) is an epithelial-specific transcription factor whose expression is associated with growth arrest...
  11. pmc The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter
    W Zhang
    Departments of Medicine and Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 275:18391-8. 2000
    ..We show that the gene encoding the gut-enriched Krüppel-like factor (GKLF, KLF4) is concurrently induced with p21(WAF1/Cip1) during serum deprivation and DNA damage elicited by methyl ..
  12. pmc Decreased expression of the gut-enriched Krüppel-like factor gene in intestinal adenomas of multiple intestinal neoplasia mice and in colonic adenomas of familial adenomatous polyposis patients
    D T Dang
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    FEBS Lett 476:203-7. 2000
    Gut-enriched Krüppel-like factor (GKLF) is a zinc finger-containing transcription factor, the expression of which is associated with growth arrest...
  13. pmc The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon
    Jonathan P Katz
    Department of Genetics, University of Pennsylvania School of Medicine, 560 Clinical Research Building, 415 Curie Blvd, Philadelphia 19104 6145, USA
    Development 129:2619-28. 2002
    Klf4 (formerly GKLF) is a zinc-finger transcription factor expressed in the epithelia of the skin, lungs, gastrointestinal tract and several other organs...
  14. pmc Kruppel-like factor 4 mediates p53-dependent G1/S cell cycle arrest in response to DNA damage
    Hong S Yoon
    Division of Digestive Diseases, Department of Medicine and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 278:2101-5. 2003
    ..Previous studies indicate that the Krüppel-like factor 4 (KLF4) gene is activated following DNA damage and that such activation depends on p53...
  15. pmc Transcriptional profiling of Krüppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation
    Xinming Chen
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, 2101 Whitehead Research Building, Atlanta, GA 30322, USA
    J Mol Biol 326:665-77. 2003
    Krüppel-like factor 4 (KLF4) is an epithelially enriched, zinc finger-containing transcription factor, the expression of which is associated with growth arrest...
  16. ncbi Dynamic expression of Krüppel-like factor 4 (Klf4), a target of transcription factor AP-2alpha during murine mid-embryogenesis
    Julia Ehlermann
    Institute for Pathology, Department of Developmental Pathology, University of Bonn Medical School, Bonn, Germany
    Anat Rec A Discov Mol Cell Evol Biol 273:677-80. 2003
    Krüppel-like factor 4 (Klf4) belongs to the family of transcription factors that are thought to be involved in the regulation of epithelial and germ cell differentiation, based on their expression in postproliferative cells of the skin, ..
  17. pmc Requirement of Krüppel-like factor 4 in preventing entry into mitosis following DNA damage
    Hong S Yoon
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 279:5035-41. 2004
    Previous studies indicate that Krüppel-like factor 4 (KLF4 or GKLF) controls the G1/S cell cycle checkpoint upon DNA damage...
  18. ncbi Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4
    Yanjun Li
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Blood 105:635-7. 2005
    ..of 2 significantly up-regulated genes, suppressor of cytokine signaling-3 (SOCS-3) and Kruppel-like factor 4 (Klf4), was verified using Northern blotting...
  19. pmc Krüppel-like factors 4 and 5: the yin and yang regulators of cellular proliferation
    Amr M Ghaleb
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Cell Res 15:92-6. 2005
    ..b>KLF4 and KLF5 are two closely related members of the KLF family that have a similar tissue distribution in embryos and ..
  20. pmc Krüppel-like factor 4 prevents centrosome amplification following gamma-irradiation-induced DNA damage
    Hong S Yoon
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Oncogene 24:4017-25. 2005
    ..Here, we present evidence for the involvement of the mammalian Krüppel-like transcription factor, KLF4, in preventing centrosome amplification following DNA damage caused by gamma-irradiation...
  21. ncbi Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach
    Jonathan P Katz
    Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104 6145, USA
    Gastroenterology 128:935-45. 2005
    The epithelial zinc-finger transcription factor Klf4 (formerly GKLF) regulates cellular proliferation and differentiation in vitro. Klf4 null mice die by postnatal day 1 and show changes in epithelial differentiation of skin and colon.
  22. ncbi Kruppel-like factor 4 is a mediator of proinflammatory signaling in macrophages
    Mark W Feinberg
    Program in Cardiovascular Transcriptional Biology, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 280:38247-58. 2005
    ..Herein, we identify Kruppel-like factor 4 (KLF4) as being markedly induced in response to IFN-gamma, LPS, or tumor necrosis factor-alpha and decreased by TGF-beta1 ..
  23. ncbi The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene
    Benjamin D Rowland
    Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Nat Cell Biol 7:1074-82. 2005
    b>KLF4 (GKLF/EZF) encodes a transcription factor that is associated with both tumour suppression and oncogenesis. We describe the identification of KLF4 in a functional genomic screen for genes that bypass RAS(V12)-induced senescence...
  24. pmc Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells
    Yuhki Nakatake
    Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology, Minatojima minamimachi 2 2 3, Chu o ku, Kobe 650 0047, Japan
    Mol Cell Biol 26:7772-82. 2006
    ..By functional screening of ES-specific transcription factors, we found that Krüppel-like factor 4 (Klf4) cooperates with Oct3/4 and Sox2 to activate Lefty1 expression, and that Klf4 acts as a mediating factor that ..
  25. pmc Krüppel-like factor 4 exhibits antiapoptotic activity following gamma-radiation-induced DNA damage
    A M Ghaleb
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Oncogene 26:2365-73. 2007
    ..The zinc-finger-containing transcription factor, Krüppel-like factor 4 (KLF4), is a crucial mediator for the checkpoint functions of p53 after gamma-irradiation and does so by inhibiting the ..
  26. pmc Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells
    Shivalingappa K Swamynathan
    Laboratory of Molecular and Developmental Biology, National Eye Institute NIH, 7 Memorial Drive, Room 129, Bethesda, MD 20892, USA
    Mol Cell Biol 27:182-94. 2007
    The Krüppel-like transcription factor KLF4 is among the most highly expressed transcription factors in the mouse cornea (B. Norman, J. Davis, and J. Piatigorsky, Investig. Ophthalmol. Vis. Sci. 45:429-440, 2004)...
  27. ncbi Kruppel-like factor 4 regulates endothelial inflammation
    Anne Hamik
    Cardiovascular Research Institute, Case Western Reserve University, Cleveland, Ohio 44106 7290, USA
    J Biol Chem 282:13769-79. 2007
    ..These data implicate Kruppel-like factor 4 as a novel regulator of endothelial activation in response to pro-inflammatory stimuli...
  28. pmc The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology
    Beth B McConnell
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Bioessays 29:549-57. 2007
    ..b>KLF4 and KLF5 are two closely related members of this family and are both highly expressed in epithelial tissues...
  29. pmc Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis
    Amr M Ghaleb
    Division of Digestive Diseases, Department of Medicine, and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30033, USA
    Cancer Res 67:7147-54. 2007
    The zinc finger transcription factor Krüppel-like factor 4 (KLF4) is frequently down-regulated in colorectal cancer...
  30. pmc The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation
    Mark W Feinberg
    Department of Medicine, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 26:4138-48. 2007
    ..Here we show that KLF4/GKLF is expressed in a monocyte-restricted and stage-specific pattern during myelopoiesis and functions to promote ..
  31. doi KLF4 promotes the expression, translocation, and releas eof HMGB1 in RAW264.7 macrophages in response to LPS
    Junwen Liu
    Laboratory of Shock, Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, People s Republic of China
    Shock 30:260-6. 2008
    Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor with diverse regulatory functions in cell growth, proliferation, differentiation, and embryogenesis...
  32. doi A core Klf circuitry regulates self-renewal of embryonic stem cells
    Jianming Jiang
    Gene Regulation Laboratory, Genome Institute of Singapore, 60 Biopolis Street, 02 01, Genome Building, Singapore 138672
    Nat Cell Biol 10:353-60. 2008
    ..differentiated state of somatic cells back to a pluripotent state with a combination of four transcription factors: Klf4 is one of the reprogramming factors required, in conjunction with Oct4, Sox2 and c-Myc...
  33. doi KLF4 is a FOXO target gene that suppresses B cell proliferation
    Isharat Yusuf
    Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, USA
    Int Immunol 20:671-81. 2008
    ..However, the transcription factors that regulate B cell quiescence are not known. KLF4 is a candidate tumor suppressor gene in B lymphocytes, and thus a likely candidate for regulating B cell ..
  34. pmc Kruppel-like factor 4 is essential for inflammatory monocyte differentiation in vivo
    Jonathan K Alder
    Divisions of Immunology and Hematopoiesis, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    J Immunol 180:5645-52. 2008
    ..We demonstrate in this study that hematopoietic cells from KLF4(-/-) fetal livers (FL) contained normal numbers of functional hematopoietic progenitor cells, were radioprotective, ..
  35. pmc Prostaglandin E2 and Krüppel-like transcription factors synergistically induce the expression of decay-accelerating factor in intestinal epithelial cells
    Jinyi Shao
    Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
    Immunology 125:397-407. 2008
    ..Overexpression of KLF4 and KLF5 robustly induced transcriptional activity of the DAF promoter...
  36. pmc Conditional deletion of Krüppel-like factor 4 delays downregulation of smooth muscle cell differentiation markers but accelerates neointimal formation following vascular injury
    Tadashi Yoshida
    Department of Molecular Physiology and Biological Physics, University of Virginia, 415 Lane Rd, Charlottesville, VA 22908, USA
    Circ Res 102:1548-57. 2008
    ..We previously showed that Krüppel-like factor 4 (Klf4) suppressed SMC differentiation markers in cultured SMCs...
  37. pmc Notch inhibits expression of the Krüppel-like factor 4 tumor suppressor in the intestinal epithelium
    Amr M Ghaleb
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Mol Cancer Res 6:1920-7. 2008
    The zinc finger-containing transcription factor, Krüppel-like factor 4 (KLF4), inhibits cell proliferation...
  38. pmc Mouse embryonic fibroblasts null for the Krüppel-like factor 4 gene are genetically unstable
    E G Hagos
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Oncogene 28:1197-205. 2009
    Krüppel-like factor 4 (KLF4) is a zinc-finger transcription factor with tumor suppressive activity in colorectal cancer...
  39. pmc Transcription factor ELF4 controls the proliferation and homing of CD8+ T cells via the Krüppel-like factors KLF4 and KLF2
    Takeshi Yamada
    Department of Pathology, Baylor College of Medicine, Texas Children s Hospital, Houston, Texas, USA
    Nat Immunol 10:618-26. 2009
    ..Here we demonstrate that the transcription factor ELF4 directly activated the tumor suppressor KLF4 'downstream' of T cell antigen receptor signaling to induce cell cycle arrest in naive CD8(+) T cells...
  40. pmc Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors
    Akira Nishiyama
    National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Cell Stem Cell 5:420-33. 2009
    ..Of the 50 TFs, Cdx2 provoked the most extensive transcriptome perturbation in ESCs, followed by Esx1, Sox9, Tcf3, Klf4, and Gata3. ChIP-Seq revealed that CDX2 binds to promoters of upregulated target genes...
  41. pmc KLF family members regulate intrinsic axon regeneration ability
    Darcie L Moore
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Science 326:298-301. 2009
    ..screening genes developmentally regulated in retinal ganglion cells (RGCs), we identified Krüppel-like factor-4 (KLF4) as a transcriptional repressor of axon growth in RGCs and other CNS neurons...
  42. doi Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming
    Zong Wei
    Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Stem Cells 27:2969-78. 2009
    ..Oct4, Sox2, and Klf4, factors that share many target genes in embryonic stem (ES) cells, are critical components in various ..
  43. pmc KLF4 interacts with beta-catenin/TCF4 and blocks p300/CBP recruitment by beta-catenin
    Paul M Evans
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Mol Cell Biol 30:372-81. 2010
    ..Our laboratory recently found that KLF4, a transcription factor highly expressed in the adult intestine and critical for intestinal differentiation, ..
  44. pmc Kruppel-like factor 4 (Klf4) prevents embryonic stem (ES) cell differentiation by regulating Nanog gene expression
    Peilin Zhang
    Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 285:9180-9. 2010
    Transcription factor Kruppel-like factor 4 (Klf4) is essential for somatic cell reprogramming. In addition, Klf4 seems to play a redundant role along with other Klf family proteins in embryonic stem (ES) cell self-renewal...
  45. pmc Smooth and cardiac muscle-selective knock-out of Kruppel-like factor 4 causes postnatal death and growth retardation
    Tadashi Yoshida
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    J Biol Chem 285:21175-84. 2010
    Krüppel-like factor 4 (Klf4) is a transcription factor involved in differentiation and proliferation in multiple tissues...
  46. pmc Kruppel-like factor-4 transcriptionally regulates VE-cadherin expression and endothelial barrier function
    Colleen E Cowan
    Department of Pharmacology, University of Illinois, 835 S Wolcott, Room E403, Mail Code 868, Chicago, IL 60612, USA
    Circ Res 107:959-66. 2010
    ..Krüppel-like factor (KLF)4 may have an important role in mediating the expression of VE-cadherin and AJ integrity, we studied the function of KLF4 in regulating VE-cadherin expression and the control of endothelial barrier function.
  47. doi Epiblast stem cell subpopulations represent mouse embryos of distinct pregastrulation stages
    Dong Wook Han
    Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149 Munster, Germany
    Cell 143:617-27. 2010
    ..Our findings suggest that the rare ability of EpiSCs to contribute to chimeras is due to the presence of the minor EpiSC fraction representing the early epiblast...
  48. pmc Altered intestinal epithelial homeostasis in mice with intestine-specific deletion of the Krüppel-like factor 4 gene
    Amr M Ghaleb
    Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Dev Biol 349:310-20. 2011
    The zinc finger transcription factor, Krüppel-like factor 4 (KLF4), is expressed in the post-mitotic, differentiated epithelial cells lining the intestinal tract and exhibits a tumor suppressive effect on intestinal tumorigenesis...
  49. doi Direct reprogramming of fibroblasts into epiblast stem cells
    Dong Wook Han
    Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, 48149 Munster, Germany
    Nat Cell Biol 13:66-71. 2011
    ..Introduction of the four transcription factors Oct4, Sox2, Klf4 and c-Myc into somatic cells has been shown to generate induced pluripotent stem cells (iPSCs) that are very ..
  50. pmc Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells
    Luca Pellegrinet
    Ecole Polytechnique Federale de Lausanne, Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland
    Gastroenterology 140:1230-1240.e1-7. 2011
    ..Furthermore, we investigated whether the induction of goblet cell differentiation that results from loss of Notch requires the transcription factor Krüppel-like factor 4 (Klf4).
  51. doi The structure of the Klf4 DNA-binding domain links to self-renewal and macrophage differentiation
    Anja Schuetz
    Protein Sample Production Facility, Max Delbruck Centrum fur Molekulare Medizin, Robert Rossle Str 10, 13125 Berlin, Germany
    Cell Mol Life Sci 68:3121-31. 2011
    Krueppel-like factor 4 (Klf4) belongs to the Sp/Klf family of zinc-finger transcription factors and is indispensable for terminal maturation of epithelial tissues...
  52. pmc Krüppel-like factor 4 regulates macrophage polarization
    Xudong Liao
    Case Cardiovascular Research Institute, Department of Medicine, Harrington McLaughlin Heart and Vascular Institute, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, Ohio, USA
    J Clin Invest 121:2736-49. 2011
    ..Here we report our studies that identify Krüppel-like factor 4 (KLF4) as a critical regulator of macrophage polarization...
  53. pmc Krüppel-like factor 4 inhibits tumorigenic progression and metastasis in a mouse model of breast cancer
    Jennifer L Yori
    Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106 4965, USA
    Neoplasia 13:601-10. 2011
    Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor that functions as an oncogene or tumor suppressor in a highly tissue-specific cell-dependent manner...
  54. pmc Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming
    Clifford D L Folmes
    Center for Regenerative Medicine and Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Cell Metab 14:264-71. 2011
    ..Thus, the energetic infrastructure of somatic cells transitions into a required glycolytic metabotype to fuel induction of pluripotency...
  55. pmc Dysregulation of Kruppel-like factor 4 during brain development leads to hydrocephalus in mice
    Song Qin
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Proc Natl Acad Sci U S A 108:21117-21. 2011
    Kruppel-like factor 4 (KLF4) is involved in self-renewal of embryonic stem cells and reprogramming of somatic cells to pluripotency. However, its role in lineage-committed stem cells remains largely unknown...
  56. doi Krüppel-like factor 4 regulates membranous and endochondral ossification
    Ikumi Michikami
    Department of Oral Anatomy and Developmental Biology, Osaka University Graduate School of Dentistry, Yamadaoka 1 8, Suita, Osaka, 565 0871, Japan
    Exp Cell Res 318:311-25. 2012
    Krüppel-like factor 4 (KLF4/GKLF/EZF) is a zinc finger type of transcription factor highly expressed in the skin, intestine, testis, lung and bone...
  57. pmc Krüppel-like factor 4 regulates intestinal epithelial cell morphology and polarity
    Tianxin Yu
    Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS ONE 7:e32492. 2012
    Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor that plays a vital role in regulating cell lineage differentiation during development and maintaining epithelial homeostasis in the intestine...
  58. pmc Role of Kruppel-like factor 4 in neurogenesis and radial neuronal migration in the developing cerebral cortex
    Song Qin
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Mol Cell Biol 32:4297-305. 2012
    ..Krüppel-like factor 4 (KLF4) is expressed in neural stem cells and controls axonal regeneration...
  59. pmc Myeloid Krüppel-like factor 4 deficiency augments atherogenesis in ApoE-/- mice--brief report
    Nikunj Sharma
    Case Cardiovascular Research Institute, Case Western Reserve University, Cleveland, OH 44106 7290, USA
    Arterioscler Thromb Vasc Biol 32:2836-8. 2012
    To investigate the role of Krüppel-like factor 4 (KLF4), an essential transcriptional regulator of macrophage polarization (M1/M2), in the pathogenesis of atherosclerosis.
  60. pmc Endothelial Kruppel-like factor 4 protects against atherothrombosis in mice
    Guangjin Zhou
    Case Cardiovascular Research Institute, Case Western Reserve University, and University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    J Clin Invest 122:4727-31. 2012
    ..Here, we show that endothelial KLF4 is an essential determinant of atherogenesis and thrombosis...
  61. doi Kruppel-like factor 4 is required for the expression of vascular smooth muscle cell differentiation marker genes induced by all-trans retinoic acid
    Chao Wang
    Department of Biochemistry and Molecular Biology, Hebei Medical University, Shijiazhuang 050017, China
    J Biochem 144:313-21. 2008
    Krüppel-like factor 4 (KLF4) is involved in phenotypic modulation of vascular smooth muscle cells (VSMCs). All-trans retinoic acid (ATRA) inhibits VSMC proliferation and induces VSMC differentiation...
  62. pmc KLF4 gene expression is inhibited by the notch signaling pathway that controls goblet cell differentiation in mouse gastrointestinal tract
    Hai Zheng
    Department of Pathology, Microbiology and Immunology, University of South Carolina, School of Medicine, 6439 Garners Ferry Road, Columbia, SC 29208, USA
    Am J Physiol Gastrointest Liver Physiol 296:G490-8. 2009
    ..The aim of this study was to examine whether Notch represses KLF4 expression to regulate goblet cell differentiation...
  63. pmc Disruption of Klf4 in villin-positive gastric progenitor cells promotes formation and progression of tumors of the antrum in mice
    Qiang Li
    Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Gastroenterology 142:531-42. 2012
    Krüppel-like factor 4 (Klf4) is a putative gastric tumor suppressor gene. Rare, villin-positive progenitor cells in the gastric antrum have multilineage potential...
  64. pmc Non-viral expression of mouse Oct4, Sox2, and Klf4 transcription factors efficiently reprograms tadpole muscle fibers in vivo
    Céline Vivien
    UMR CNRS 7221, Evolution des Regulations Endocriniennes, Département Régulations Développement et Diversité Mole culaire, Muse um National d Histoire Naturelle, 75231 Paris, France
    J Biol Chem 287:7427-35. 2012
    ..The work opens new perspectives in basic stem cell research and in the longer term prospect of regenerative medicine protocols development...
  65. doi Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells
    Katrin Hoffmeyer
    Department of Molecular Embryology, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany
    Science 336:1549-54. 2012
    ..We show that β-catenin regulates Tert expression through the interaction with Klf4, a core component of the pluripotency transcriptional network...
  66. pmc Krüppel-like factor 4, a tumor suppressor in hepatocellular carcinoma cells reverts epithelial mesenchymal transition by suppressing slug expression
    Ze Shiang Lin
    National Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan
    PLoS ONE 7:e43593. 2012
    Krüppel-like factor 4 (KLF4) is a zinc-finger transcription factor that plays an important role in differentiation and pathogenesis. KLF4 has been suggested to act as an oncogene or tumor suppressor in different tumor types...
  67. doi Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
    Katrin Kierdorf
    Department of Neuropathology, University of Freiburg, Freiburg, Germany
    Nat Neurosci 16:273-80. 2013
    ..as Sfpi), but also required Irf8, which was vital for the development of the A2 population, whereas Myb, Id2, Batf3 and Klf4 were not required. Our data provide cellular and molecular insights into the origin and development of microglia.
  68. pmc Klf4 is a transcriptional regulator of genes critical for EMT, including Jnk1 (Mapk8)
    Neha Tiwari
    Department of Biomedicine, University of Basel, Basel, Switzerland
    PLoS ONE 8:e57329. 2013
    We have identified the zinc-finger transcription factor Kruppel-like factor 4 (Klf4) among the transcription factors that are significantly downregulated in their expression during epithelial-mesenchymal transition (EMT) in mammary ..
  69. pmc Two potent nuclear localization signals in the gut-enriched Krüppel-like factor define a subfamily of closely related Krüppel proteins
    J M Shields
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 272:18504-7. 1997
    The gut-enriched Krüppel-like factor (GKLF) is a newly identified transcription factor that contains three C2H2 Krüppel-type zinc fingers. Previous immunocytochemical studies indicate that GKLF is exclusively localized to the nucleus...
  70. ncbi Developmental expression of the mouse gene coding for the Krüppel-like transcription factor KLF5
    S Ohnishi
    Genetics Division, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Dev Dyn 217:421-9. 2000
    ..we examined the developmental expression of the mouse Klf5 gene and compared it to the established pattern of the Klf4 gene. The results revealed that the two genes are expressed in both overlapping and mutually exclusive patterns...
  71. pmc Opposing effects of Krüppel-like factor 4 (gut-enriched Krüppel-like factor) and Krüppel-like factor 5 (intestinal-enriched Krüppel-like factor) on the promoter of the Krüppel-like factor 4 gene
    Duyen T Dang
    Division of Gastroenterology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Nucleic Acids Res 30:2736-41. 2002
    KLF4 (Krüppel-like factor 4 or gut-enriched Krüppel-like factor, GKLF) and KLF5 (Krüppel-like factor 5 or intestinal-enriched Krüppel-like factor, IKLF) are two closely related members of the zinc finger-containing Krüppel-like ..
  72. ncbi A transforming growth factor-beta control element required for SM alpha-actin expression in vivo also partially mediates GKLF-dependent transcriptional repression
    Yan Liu
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 278:48004-11. 2003
    ..in transgenic mice and 2) further characterize the possible role and mechanisms by which the TCE-binding factor GKLF/KLF4 induces repression of SMC marker genes in various SMC model systems in vitro...
  73. pmc Epidermal barrier formation and recovery in skin disorders
    Julia A Segre
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892 4442, USA
    J Clin Invest 116:1150-8. 2006
    ....
  74. pmc KLF4 suppresses transformation of pre-B cells by ABL oncogenes
    Michael G Kharas
    Department of Molecular Biology and Biochemistry, University of California Irvine, 3242 McGaugh Hall, Irvine, CA 92697 3900, USA
    Blood 109:747-55. 2007
    ..Krüppel-like factor 4 (Klf4), a gene down-regulated in activated murine B cells, is expressed at low levels in several types of human B-cell ..
  75. pmc Induction of KLF4 in response to heat stress
    Ying Liu
    Laboratory of Shock, Department of Pathophysiology, Xiangya School of Medicine, Central South University, 110 Xiangya Road, Changsha, Hunan 410008, People s Republic of China
    Cell Stress Chaperones 11:379-89. 2006
    Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor with diverse regulatory functions in cell growth, proliferation, differentiation, and embryogenesis...
  76. ncbi KLF4 regulates the expression of interleukin-10 in RAW264.7 macrophages
    Junwen Liu
    Laboratory of Shock, Department of Pathophysiology, Xiangya School of Medicine, Central South University, 110 Xiangya Road, Changsha, Hunan 410008, People s Republic of China
    Biochem Biophys Res Commun 362:575-81. 2007
    Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor. In the current study, RAW264...
  77. pmc Krüppel-like factor 4 regulates B cell number and activation-induced B cell proliferation
    Jettanong Klaewsongkram
    Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    J Immunol 179:4679-84. 2007
    Krüppel-like factor 4 (Klf4) is a transcription factor and functions in regulating cell differentiation, cell growth, and cell cycle. Although Klf4 is expressed in lymphocytes, its function in lymphocytes is unknown...
  78. pmc Detailed characterization of the mouse embryonic stem cell transcriptome reveals novel genes and intergenic splicing associated with pluripotency
    Galih Kunarso
    Computational and Mathematical Biology, Genome Institute of Singapore, 60 Biopolis Street 02 01, Singapore 138672, Singapore
    BMC Genomics 9:155. 2008
    ..To identify novel genes associated with pluripotency, we globally searched for ES transcripts not corresponding to known genes, validated their sequences, determined their expression profiles, and employed RNAi to test their function...
  79. pmc Klf4 reverts developmentally programmed restriction of ground state pluripotency
    Ge Guo
    Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Cambridge CB2 1QR, UK
    Development 136:1063-9. 2009
    ..We exploited PiggyBac transposition to introduce a single reprogramming factor, Klf4, into EpiSCs...
  80. doi Spatial and temporal expression of KLF4 and KLF5 during murine tooth development
    Zhuo Chen
    Key Laboratory for Oral Biomedical Engineering of Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei 430079, PR China
    Arch Oral Biol 54:403-11. 2009
    b>KLF4 and KLF5, members of the Krüppel-like factor (KLF) family, play key roles in proliferation, differentiation and apoptosis during development...
  81. pmc Stromal edema in klf4 conditional null mouse cornea is associated with altered collagen fibril organization and reduced proteoglycans
    Robert D Young
    Structural Biophysics Group, School of Optometry and Vision Sciences, Cardiff University, Cardiff, Wales, United Kingdom
    Invest Ophthalmol Vis Sci 50:4155-61. 2009
    b>Klf4, one of the highly expressed transcription factors in the mouse cornea, plays an important role in maturation and maintenance of the ocular surface...
  82. pmc C-terminal binding proteins (CtBPs) attenuate KLF4-mediated transcriptional activation
    Gang Liu
    Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC 29208, USA
    FEBS Lett 583:3127-32. 2009
    We aimed to examine the physical interaction between CtBPs and KLF4 and the potential importance of this interaction. Co-immunoprecipitation indicated that CtBP1 indeed interacted with KLF4...
  83. pmc Akt-dependent Pp2a activity is required for epidermal barrier formation during late embryonic development
    Ryan F L O'Shaughnessy
    Centre for Cutaneous Research, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, UK
    Development 136:3423-31. 2009
    ..We therefore describe a novel Akt-dependent Pp2a activity that acts at least partly through Jun to affect initial barrier formation during late embryonic epidermal development...
  84. pmc Esophageal squamous cell dysplasia and delayed differentiation with deletion of krüppel-like factor 4 in murine esophagus
    Marie Pier Tetreault
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6144, USA
    Gastroenterology 139:171-81.e9. 2010
    ..Homozygous null mice for Klf4 die shortly after birth from skin defects, precluding their analysis at later stages...
  85. pmc Platelet factor 4 regulation of monocyte KLF4 in experimental cerebral malaria
    Kalyan Srivastava
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, New York, United States of America
    PLoS ONE 5:e10413. 2010
    ..We now show that PF4 drives monocyte cytokine production in a Kruppel like factor 4 (KLF4) dependent manner...
  86. pmc Dynamic methylation and expression of Oct4 in early neural stem cells
    Shih Han Lee
    Children s Brain Tumour Research Centre, Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham, UK
    J Anat 217:203-13. 2010
    ..We also found that neural stem cells from all ages expressed the pluripotency associated genes, Sox2, c-Myc, Klf4 and Nanog...
  87. pmc Cutting edge: The transcription factor Kruppel-like factor 4 regulates the differentiation of Th17 cells independently of RORγt
    Lori Lebson
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Immunol 185:7161-4. 2010
    ..b>KLF4 was required for the production of IL-17, and further, chromatin immunoprecipitation analysis demonstrated binding ..
  88. doi Molecular coupling of Tsix regulation and pluripotency
    Pablo Navarro
    Unité de Génétique Moléculaire Murine, URA 2578, Institut Pasteur, 75724 Paris Cedex 15, France
    Nature 468:457-60. 2010
    ..stem cells depends on the recruitment of the pluripotent marker Rex1, and of the reprogramming-associated factors Klf4 and c-Myc, by the DXPas34 minisatellite associated with the Tsix promoter...
  89. doi The Krüppel-like factor 4 controls biosynthesis of thyrotropin-releasing hormone during hypothalamus development
    Carlos Pérez-Monter
    Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos 62271, Mexico
    Mol Cell Endocrinol 333:127-33. 2011
    ..Here, we show that the Klf4 gene, encoding the transcription factor Krüppel-like factor 4 (Klf4), was expressed in the rat hypothalamus during ..
  90. pmc KLF4-mediated negative regulation of IFITM3 expression plays a critical role in colon cancer pathogenesis
    Dawei Li
    Departments of General Surgery and Pathology, Shanghai Jiaotong University Affiliated First People s Hospital, Shanghai, PR China
    Clin Cancer Res 17:3558-68. 2011
    ..In this study, we sought to determine the clinical significance and underlying mechanisms of its dysregulated expression in human colon tumor specimens and murine models of this disease...
  91. pmc The transcriptional repressor Blimp1/Prdm1 regulates postnatal reprogramming of intestinal enterocytes
    James Harper
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    Proc Natl Acad Sci U S A 108:10585-90. 2011
    ..In contrast, those required for processing maternal milk were markedly reduced. Thus, we conclude Blimp1 governs the developmental switch responsible for postnatal intestinal maturation...
  92. pmc Krüppel-like factor 4 (KLF4) directly regulates proliferation in thymocyte development and IL-17 expression during Th17 differentiation
    Jie An
    Laboratory of Molecular Biology and Immunology, National Institutes of Health, Baltimore, Maryland, USA
    FASEB J 25:3634-45. 2011
    Krüppel-like factor 4 (KLF4), a transcription factor, plays a key role in the pluripotency of stem cells...
  93. ncbi Verification and initial annotation of the NIA mouse 15K cDNA clone set
    G J Kargul
    Nat Genet 28:17-8. 2001
  94. ncbi Ectopic expression of kruppel like factor 4 (Klf4) accelerates formation of the epidermal permeability barrier
    Jean Jaubert
    National Human Genome Research Institute, NIH, 49 Convent Drive, Bethesda, MD 20892, USA
    Development 130:2767-77. 2003
    ..The transcription factor kruppel-like factor 4 (Klf4), has been shown by a targeted ablation, to have an essential function in barrier acquisition...
  95. ncbi Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation
    Arup Kumar Indra
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Strasbourg, France
    Development 132:4533-44. 2005
    ..Finally, we demonstrate that cell-specific targeted somatic mutations can be created at various times during the development of mouse embryos cell-specifically expressing the tamoxifen-activatable Cre-ER(T2) recombinase...
  96. pmc Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response
    Ali R Djalilian
    National Human Genome Research Institute, National Eye Institute, and National Institute of Child Health and Development, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 116:1243-53. 2006
    ..Mice lacking the transcription factor Kruppel-like factor 4 (Klf4) have a severe defect in epidermal barrier acquisition...
  97. pmc Upregulation of the constitutively expressed HSC70 by KLF4
    Ying Liu
    Laboratory of Shock, Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, 410008, People s Republic of China
    Cell Stress Chaperones 13:337-45. 2008
    Krüppel-like factor 4 (KLF4) is a transcription factor that is abundantly expressed in various organisms from bacteria to mammals. It has been demonstrated that KLF4 regulates the expression of a wide range of genes...
  98. pmc Transcriptional regulation of adipogenesis by KLF4
    Kivanc Birsoy
    Laboratory of Molecular Genetics, Rockefeller University, New York, NY 10021, USA
    Cell Metab 7:339-47. 2008
    ..We report here the characterization of Krüppel-like factor 4 (KLF4) as an essential early regulator of adipogenesis...
  99. pmc Identification of candidate Klf4 target genes reveals the molecular basis of the diverse regulatory roles of Klf4 in the mouse cornea
    Shivalingappa K Swamynathan
    Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Invest Ophthalmol Vis Sci 49:3360-70. 2008
    Krüppel-like factor 4 (Klf4) plays a crucial role in the development and maintenance of the mouse cornea...
  100. doi Efficient genetic reprogramming of unmodified somatic neural progenitors uncovers the essential requirement of Oct4 and Klf4
    Bruno Di Stefano
    Stem Cell Research Department, San Raffaele Scientific Institute, Via Olgettina 58, Milan, Italy
    Stem Cells Dev 18:707-16. 2009
    ..Retroviral transduction of the factors Oct4, Sox2, Klf4, and c-Myc successfully reverted NSCs to a pluripotent embryonic stem cell-like state with a 2-fold efficiency ..

Research Grants4

  1. Inhibition of Macrophage Activation by Smad3
    Mark Feinberg; Fiscal Year: 2005
    ..Insight into the mechanism governing SmadYs role in inflammation may provide potential, therapeutic targets applicable to a number of inflammatory diseases. ..
  2. KLF4, TGF-b1, and transplantation arteriosclerosis
    Mark W Feinberg; Fiscal Year: 2010
    ..We identified a member of this family termed KLF4 whose expression is highly expressed in macrophages associated with heart transplant lesions in vivo...
  3. REGULATION OF HUMAN GAMMA AND BETA GLOBIN GENES
    Joyce Lloyd; Fiscal Year: 2003
    ..These results will predict the proteins involved in early beta-globin gene suppression. ..
  4. Role of KLF2 in erythropoiesis and globin expression
    Joyce A Lloyd; Fiscal Year: 2010
    ..Our long-term goal is to use KLF2 in strategies to increase embryonic/fetal beta-globin, to treat patients with beta-hemoglobinopathies. ..