Kit

Summary

Gene Symbol: Kit
Description: KIT proto-oncogene receptor tyrosine kinase
Alias: CD117, Fdc, Gsfsco1, Gsfsco5, Gsfsow3, SCO1, SCO5, SOW3, Ssm, Tr-kit, c-KIT, mast/stem cell growth factor receptor Kit, Dominant white spotting, SCFR, Steel Factor Receptor, belly-spot, c-kit proto-oncogene protein, dominant spotting, kit oncogene, proto-oncogene c-Kit, proto-oncogene tyrosine-protein kinase Kit, spotted sterile male, tyrosine-protein kinase Kit
Species: mouse

Top Publications

  1. pmc Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo
    Michele A Grimbaldeston
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Am J Pathol 167:835-48. 2005
  2. pmc Mast cells are essential for early onset and severe disease in a murine model of multiple sclerosis
    V H Secor
    Graduate Program in Immunology and Molecular Pathogenesis, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Exp Med 191:813-22. 2000
  3. ncbi Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection
    James B McLachlan
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Immunol 4:1199-205. 2003
  4. pmc Genetic inversion in mast cell-deficient (Wsh) mice interrupts corin and manifests as hematopoietic and cardiac aberrancy
    Peter A Nigrovic
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Pathol 173:1693-701. 2008
  5. doi Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells
    Kazuyo Moro
    Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    Nature 463:540-4. 2010
  6. ncbi The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus
    B Chabot
    Division of Molecular and Developmental Biology, Mount Sinai Hospital Research Institute, Toronto, Ontario, Canada
    Nature 335:88-9. 1988
  7. ncbi A role for hematopoietic stem cells in promoting angiogenesis
    N Takakura
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Japan
    Cell 102:199-209. 2000
  8. pmc Synaptotagmin-2 controls regulated exocytosis but not other secretory responses of mast cells
    Ernestina Melicoff
    Department of Pulmonary Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 284:19445-51. 2009
  9. pmc Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation
    Cong Jin
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27514, USA
    J Clin Invest 121:941-55. 2011
  10. ncbi W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity
    J D Huizinga
    Department of Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada
    Nature 373:347-9. 1995

Research Grants

  1. Chemoprevention of IBD-Associated Colon Cancer
    Laura P Hale; Fiscal Year: 2010
  2. Inflammatory mediators and UV-induced carcinogenesis
    Stephen Ullrich; Fiscal Year: 2009
  3. Genetic remodeling of Vagal Afferent Organization
    Edward Fox; Fiscal Year: 2009
  4. Keratinocyte-derived immuno-suppressive cytokines
    Stephen Ullrich; Fiscal Year: 2005
  5. IN UTERO STEM CELL TRANSFER IN MPS VII
    Brian Soper; Fiscal Year: 2005
  6. Do NKT cells mediate UV induced Immune Suppression?
    Stephen Ullrich; Fiscal Year: 2005
  7. Novel Oral Adjuvant for Dental Vaccines
    LAURA HALE; Fiscal Year: 2005
  8. Mast Cells and IBD Pathogenesis
    LAURA HALE; Fiscal Year: 2007
  9. Bromelain as a Biologically-Based Therapy for IBD
    LAURA HALE; Fiscal Year: 2005
  10. Bromelain Proteinase Activity in IBD
    LAURA HALE; Fiscal Year: 2006

Detail Information

Publications196 found, 100 shown here

  1. pmc Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo
    Michele A Grimbaldeston
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Am J Pathol 167:835-48. 2005
    Mice carrying certain mutations in the white spotting (W) locus (ie, c-kit) exhibit reduced c-kit tyrosine kinase-dependent signaling that results in mast cell deficiency and other phenotypic abnormalities...
  2. pmc Mast cells are essential for early onset and severe disease in a murine model of multiple sclerosis
    V H Secor
    Graduate Program in Immunology and Molecular Pathogenesis, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Exp Med 191:813-22. 2000
    ..These data provide a new mechanism for immune destruction in EAE and indicate that mast cells play a broader role in neurologic inflammation...
  3. ncbi Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection
    James B McLachlan
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Immunol 4:1199-205. 2003
    ..These results show a critical function for peripheral mast cell-derived tumor necrosis factor in regulating the hypertrophy of draining lymph nodes during infection...
  4. pmc Genetic inversion in mast cell-deficient (Wsh) mice interrupts corin and manifests as hematopoietic and cardiac aberrancy
    Peter A Nigrovic
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Pathol 173:1693-701. 2008
    ..cells was established in mice that lacked mast cells through defects in either stem cell factor or its receptor, Kit. Among available strains, C57BL/6-Kit(W-sh) (W(sh)) mice are experimentally advantageous because of their ..
  5. doi Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells
    Kazuyo Moro
    Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    Nature 463:540-4. 2010
    ..These cells do not express lineage (Lin) markers but do express c-Kit, Sca-1 (also known as Ly6a), IL7R and IL33R...
  6. ncbi The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus
    B Chabot
    Division of Molecular and Developmental Biology, Mount Sinai Hospital Research Institute, Toronto, Ontario, Canada
    Nature 335:88-9. 1988
    ..Here we show that the mouse mutant W has a deletion of the c-kit proto-oncogene...
  7. ncbi A role for hematopoietic stem cells in promoting angiogenesis
    N Takakura
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Japan
    Cell 102:199-209. 2000
    ..HSCs, which express Ang1, directly promoted migration of ECs in vivo and in vitro. These results indicate that HSCs are critical for angiogenesis...
  8. pmc Synaptotagmin-2 controls regulated exocytosis but not other secretory responses of mast cells
    Ernestina Melicoff
    Department of Pulmonary Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 284:19445-51. 2009
    ..Unlike neurons, the lack of Synaptotagmin-2 in mast cells was not associated with increased spontaneous exocytosis...
  9. pmc Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation
    Cong Jin
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27514, USA
    J Clin Invest 121:941-55. 2011
    ..These results reveal how the physical attributes of allergens can co-opt MC endocytic circuitry and signaling responses to aggravate pathological responses of allergic asthma in mice...
  10. ncbi W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity
    J D Huizinga
    Department of Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada
    Nature 373:347-9. 1995
    ..Furthermore, mice with mutations in the dominant white spotting (W) locus, which have cellular defects in haematopoiesis, melanogenesis and gametogenesis as a result of ..
  11. pmc Tissue-selective mast cell reconstitution and differential lung gene expression in mast cell-deficient Kit(W-sh)/Kit(W-sh) sash mice
    P J Wolters
    Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0911, USA
    Clin Exp Allergy 35:82-8. 2005
    Mast cell-deficient Kit(W)/Kit(W-v) mice are an important resource for studying mast cell functions in vivo...
  12. pmc Three-dimensional cartography of hematopoietic clusters in the vasculature of whole mouse embryos
    Tomomasa Yokomizo
    Erasmus MC Stem Cell Institute, Department of Cell Biology, Erasmus Medical Center, 3000 CA, Rotterdam, The Netherlands
    Development 137:3651-61. 2010
    ..Clusters enriched with the c-Kit(+)CD31(+)SSEA1(-) cell population contain functional hematopoietic progenitors and stem cells...
  13. pmc Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles
    Sung Jin Hwang
    Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA
    J Physiol 587:4887-904. 2009
    ..Loss of function of ANO1 did not inhibit the development of ICC networks that appeared structurally normal as indicated by Kit antibodies. These data demonstrate the fundamental role of ANO1 in the generation of slow waves in GI ICC.
  14. pmc Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2
    T Biedermann
    Department of Dermatology and Allergology, Ludwig Maximilians University Munich, 80337 Munich, Germany
    J Exp Med 192:1441-52. 2000
    ..abundant during DTHRs in and around mast cells of wild-type (WT) mice but absent in mast cell-deficient WBB6F(1)-Kit(W)/Kit(W-)(v) (Kit(W)/Kit(W)(-v)) mice...
  15. ncbi Mast cells can enhance resistance to snake and honeybee venoms
    Martin Metz
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Science 313:526-30. 2006
    ..These findings identify a new biological function for mast cells in enhancing resistance to the morbidity and mortality induced by animal venoms...
  16. ncbi The dominant W42 spotting phenotype results from a missense mutation in the c-kit receptor kinase
    J C Tan
    Molecular Biology Program, Sloan Kettering Institute, New York, NY 10021
    Science 247:209-12. 1990
    The murine white spotting locus (W) is allelic with the proto-oncogene c-kit, which encodes a transmembrane tyrosine protein kinase receptor for an unknown ligand...
  17. pmc Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W
    K Nocka
    Molecular Biology Program, Sloan Kettering Institute, New York, NY 10021
    EMBO J 9:1805-13. 1990
    The proto-oncogene c-kit encodes a transmembrane tyrosine protein kinase receptor for an unknown ligand and is allelic with the murine white-spotting locus (W)...
  18. pmc Exon skipping by mutation of an authentic splice site of c-kit gene in W/W mouse
    S Hayashi
    Department of Pathology, Kumamoto University Medical School, Japan
    Nucleic Acids Res 19:1267-71. 1991
    The murine mutation dominant white spotting (W) is in the proto-oncogene, c-kit. The receptor tyrosine kinase encoded by this gene has pleiotropic effects on murine development including hemopoietic cells, pigment cells, and germ cells...
  19. ncbi Pro-thymocyte expansion by c-kit and the common cytokine receptor gamma chain is essential for repertoire formation
    H R Rodewald
    Basel Institute for Immunology, Switzerland
    Immunity 6:265-72. 1997
    ..Mutations in the receptor tyrosine kinase c-kit and the common cytokine receptor gamma chain (gamma c) reduce cellularity, but are permissive for thymocyte ..
  20. pmc Stem cell factor and its receptor, c-kit, are important for hepatocyte proliferation in wild-type and tumor necrosis factor receptor-1 knockout mice after 70% hepatectomy
    Xiaodan Ren
    Department of Surgery, University of Michigan Medical School, Ann Arbor, Mich
    Surgery 143:790-802. 2008
    ..We now hypothesize that TNF-alpha's hepatoproliferative effects are also dependent on SCF...
  21. pmc CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity
    Min Cheng
    Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Circ Res 107:1083-93. 2010
    ..c-kit, a membrane-bound tyrosine kinase and the receptor for stem cell factor, has also been shown to play a critical ..
  22. ncbi Hematopoietic stem cell and progenitor defects in Sca-1/Ly-6A-null mice
    Caryn Y Ito
    Programme in Cancer Blood, Hospital for Sick Children, Toronto, ON, Canada
    Blood 101:517-23. 2003
    ..Thus, our studies conclusively demonstrate that Sca-1, in addition to being a marker of HSCs, regulates the developmental program of HSCs and specific progenitor populations...
  23. pmc The lineage-c-Kit+Sca-1+ cell response to Escherichia coli bacteremia in Balb/c mice
    Ping Zhang
    Department of Medicine, Section of Pulmonary Critical Care Medicine, LSU Health Sciences Center, New Orleans, Louisiana 70112 1393, USA
    Stem Cells 26:1778-86. 2008
    ..v. injection of Escherichia coli. Bacteremia caused a 10-fold increase in the number of lineage (lin)-c-kit+Sca-1+ cells in the bone marrow...
  24. pmc BMP-2 and FGF-2 synergistically facilitate adoption of a cardiac phenotype in somatic bone marrow c-kit+/Sca-1+ stem cells
    Brent R DeGeorge
    Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Clin Transl Sci 1:116-25. 2008
    ..For this purpose, green fluorescent protein (GFP) expressing hematopoietic lineage negative (lin-) c-kit ligand (c-kit) and stem cell antigen-1 (Sca-1) positive (GFP-lin-/c-kit+/sca+) mBMSC were co-cultured with neonatal ..
  25. ncbi Mast cells are essential intermediaries in regulatory T-cell tolerance
    Li Fan Lu
    Department of Microbiology and Immunology, Dartmouth Medical School and the Norris Cotton Cancer Center, Lebanon, New Hampshire 03756, USA
    Nature 442:997-1002. 2006
    ..Finally, immunohistochemical analysis clearly demonstrates the existence of this novel T(Reg)-IL-9-mast cell relationship within tolerant allografts...
  26. pmc Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation
    Nicolas Charles
    Laboratory of Immune Cell Signaling, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 30:533-43. 2009
    ..Our findings demonstrate that basophil-expressed Lyn kinase exerts regulatory control on Th2 cell differentiation and function...
  27. ncbi Impact of CD40 ligand, B cells, and mast cells in peanut-induced anaphylactic responses
    Jiangfeng Sun
    Division of Respiratory Diseases and Allergy, Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Immunol 179:6696-703. 2007
    ..Our data also show that MC-deficient (Kit(W)/Kit(W-v)) mice did not suffer, unlike their littermate controls, anaphylactic reactions despite the fact that ..
  28. ncbi Contiguous patterns of c-kit and steel expression: analysis of mutations at the W and Sl loci
    B Motro
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Development 113:1207-21. 1991
    ..and microenvironmental nature of W and Sl mutations, respectively, it has recently been shown that W encodes the c-kit receptor tyrosine kinase while Sl encodes a ligand for this receptor...
  29. ncbi C-kit gene is expressed by skin mast cells in embryos but not in puppies of Wsh/Wsh mice: age-dependent abolishment of c-kit gene expression
    M Yamazaki
    Department of Pathology, Osaka University Medical School, Japan
    Blood 83:3509-16. 1994
    The Wsh is a mutant allele at the W (c-kit) locus of mice, but no significant abnormalities are found at the coding region of the Wsh allele...
  30. ncbi Lower esophageal sphincter is achalasic in nNOS(-/-) and hypotensive in W/W(v) mutant mice
    D V Sivarao
    Center for Swallowing and Motility Disorders, Department of Veterans Affairs Medical Center, 1400 VFW Parkway, West Roxbury, Massachusetts 02132, USA
    Gastroenterology 121:34-42. 2001
    ..We determined whether mice with neuronal nitric oxide synthase gene disruption (nNOS(-/-)) and W/W(v) mice lacking ICC-IM have achalasia-like LES dysfunction...
  31. pmc Retinoic acid regulates sex-specific timing of meiotic initiation in mice
    Jana Koubova
    Howard Hughes Medical Institute, and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 103:2474-9. 2006
    ..Because RA signaling regulates Stra8 expression in both embryonic ovaries and adult testes, this portion of the meiotic initiation pathway may be identical in both sexes...
  32. pmc Mast cell IL-4 expression is regulated by Ikaros and influences encephalitogenic Th1 responses in EAE
    Gregory D Gregory
    Department of Microbiology Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 3010, USA
    J Clin Invest 116:1327-36. 2006
    ..These events likely contribute to the genetically determined heterogeneity in Th1 responses that underlie susceptibility to many diseases...
  33. ncbi Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors
    K Mackarehtschian
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Immunity 3:147-61. 1995
    ..Mice deficient for both c-kit and flk2 exhibited a more severe phenotype characterized by large overall decreases in hematopoietic cell numbers, ..
  34. pmc Rump white inversion in the mouse disrupts dipeptidyl aminopeptidase-like protein 6 and causes dysregulation of Kit expression
    R B Hough
    Center for Neurobiology and Behavior of the Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 95:13800-5. 1998
    ..These studies indicate that the distal breakpoint of the inversion is associated with ectopic Kit expression and therefore may be responsible for the dominant pigmentation defect in Rw/+ mice; whereas the ..
  35. ncbi Structure and regulation of Kit protein-tyrosine kinase--the stem cell factor receptor
    Robert Roskoski
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1100 Florida Avenue, New Orleans, LA 70119, USA
    Biochem Biophys Res Commun 338:1307-15. 2005
    Signaling by stem cell factor and Kit, its receptor, play important roles in gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis. Moreover, human and mouse embryonic stem cells express Kit transcripts...
  36. ncbi Characteristics of stria vascularis melanocytes of viable dominant spotting (Wv/Wv) mouse mutants
    J Cable
    MRC Institute of Hearing Research, University Park, Nottingham, UK
    Hear Res 64:6-20. 1992
    ..Viable Dominant Spotting (Wv/Wv) mouse mutants have a white coat due to the absence of melanocytes...
  37. ncbi Mast cell number in the skin of heterozygotes reflects the molecular nature of c-kit mutation
    T Tsujimura
    Department of Pathology, Medical School, Osaka University, Japan
    Blood 81:2530-8. 1993
    The W locus of mice encodes the c-kit receptor tyrosine kinase. Heterozygous WJic/+ and Wn/+ mice and homozygous Wf/Wf mice were similar in appearance; all of them have large depigmented areas lacking any well-defined pattern...
  38. ncbi Dynamic changes in ovarian c-kit and Steel expression during the estrous reproductive cycle
    B Motro
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Dev Dyn 197:69-79. 1993
    ..with the cell autonomous and microenvironmental nature of W and Sl mutations, respectively, W encodes the c-kit receptor tyrosine kinase while Steel encodes the Kit ligand...
  39. ncbi Tyrosine kinase-deficient Wv c-kit induces mast cell adhesion and chemotaxis
    J Dastych
    Department of Biogenic Amines, Polish Academy of Sciences, 90 950 Lodz, Poland
    Am J Physiol 275:C1291-9. 1998
    ..are deficient in tissue mast cells, and mast cells cultured from these mice do not proliferate in response to the c-kit ligand, stem cell factor (SCF)...
  40. ncbi The W(sh), W(57), and Ph Kit expression mutations define tissue-specific control elements located between -23 and -154 kb upstream of Kit
    G Berrozpe
    Molecular Biology Program Sloan Kettering Institute, New York, NY, USA
    Blood 94:2658-66. 1999
    The Kit and PDGFRa receptor tyrosine kinases are encoded in close proximity at the murine white spotting (W) and patch (Ph) loci...
  41. ncbi Viable c-Kit(W/W) mutants reveal pivotal role for c-kit in the maintenance of lymphopoiesis
    Claudia Waskow
    Department for Immunology, University of Ulm, Ulm, Germany
    Immunity 17:277-88. 2002
    Mice lacking the receptor tyrosine kinase c-Kit (c-Kit(W/W)) have hematopoietic defects causing perinatal death. We have identified a viable c-Kit(W/W) mouse, termed the "Vickid" mouse...
  42. ncbi Necessity of extracellular domain of W (c-kit) receptors for attachment of murine cultured mast cells to fibroblasts
    S Adachi
    Department of Pathology, Osaka University Medical School, Suita, Japan
    Blood 79:650-6. 1992
    The receptor encoded by the W (c-kit) locus (W receptor) is expressed on the surface of cultured mast cells (CMC) derived from normal (+/+) mice, whereas its ligand encoded by the Sl locus (Sl ligand) is expressed on the surface of ..
  43. pmc Role of kit-ligand in proliferation and suppression of apoptosis in mast cells: basis for radiosensitivity of white spotting and steel mutant mice
    N S Yee
    Molecular Biology Program, Sloan Kettering Institute, New York
    J Exp Med 179:1777-87. 1994
    The receptor tyrosine kinase Kit and its cognate ligand KL/steel factor are encoded at the white spotting (W) and Steel (Sl) loci of the mouse, respectively...
  44. ncbi Bile reflux due to disturbed gastric movement is a cause of spontaneous gastric ulcer in W/Wv mice
    T Azuma
    Second Department of Internal Medicine, Faculty of Medicine, Fukui Medical University, Japan
    Dig Dis Sci 44:1177-83. 1999
    c-Kit is a receptor tyrosine kinase, and it is encoded by the mouse W locus. Mutant W/Wv mice develop spontaneous gastric antral ulcers...
  45. ncbi Functional natural killer T cells in experimental mouse strains, including NK1.1- strains
    I Serizawa
    Division of Laboratory Animal Science, Nippon Veterinary and Animal Science University, Tokyo, Japan
    Exp Anim 49:171-80. 2000
    ..This is the first report to show the functional significance of NKT cells in cytokine secretion in various mouse strains in response to a ligand for the T cell receptor of NKT cells...
  46. ncbi Mast cell-mediated inflammatory responses require the alpha 2 beta 1 integrin
    Brian T Edelson
    Department of Pathology, Washington University School of Medicine, St Louis, MO, USA
    Blood 103:2214-20. 2004
    ..We conclude that alpha 2 beta 1 integrin provides a costimulatory function required for mast cell activation and cytokine production in response to infection...
  47. doi Brief report: interferon-gamma induces expansion of Lin(-)Sca-1(+)C-Kit(+) Cells
    Xin Zhao
    Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA
    Stem Cells 28:122-6. 2010
    ..Here we show that Th1 cell products, but not those of Th2 cells, caused a rapid expansion of lineage(-)Sca-1(+)C-kit(+) (LSK) cells in vivo and in vitro...
  48. doi An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions
    Kaori Hitomi
    Department of Immunology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    Nat Immunol 11:601-7. 2010
    ..Moreover, mice deficient in Allergin-1 developed enhanced passive systemic and cutaneous anaphylaxis. Thus, Allergin-1 suppresses IgE-mediated, mast cell-dependent anaphylaxis in mice...
  49. doi Distribution of transient receptor potential vanilloid 1 channel-expressing nerve fibers in mouse rectal and colonic enteric nervous system: relationship to peptidergic and nitrergic neurons
    K Matsumoto
    Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Josai International University, 1 Gumyo, Togane, Chiba 283 8555, Japan
    Neuroscience 172:518-34. 2011
    ..SP and NKA were almost entirely colocalized at the axons and cell bodies in all layers. Double labeling with c-Kit revealed that TRPV1 nerve fibers localized adjacent to the interstitial cells of Cajal (ICC)...
  50. pmc Expression and function of c-kit in hemopoietic progenitor cells
    M Ogawa
    Department of Pathology, Kumamoto University Medical School, Japan
    J Exp Med 174:63-71. 1991
    The expression and function of a receptor tyrosine kinase, c-kit, in the adult bone marrow of the mouse were investigated by using monoclonal antibodies (mAbs) against the extracellular domain of murine c-kit. In adult C57BL/6 mouse, 7...
  51. pmc Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family--oncogenic activation of v-kit involves deletion of extracellular domain and C terminus
    F H Qiu
    Laboratory of Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10021
    EMBO J 7:1003-11. 1988
    The protein kinase domains of v-kit, the oncogene of the acute transforming feline retrovirus HZ4-FeSV (HZ4-feline sarcoma virus), CSF-1R (macrophage colony stimulating factor receptor) and PDGFR (platelet derived growth factor receptor) ..
  52. pmc Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis
    I Miyajima
    Department of Pathology, Beth Israel Deaconess Medical Center East and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 99:901-14. 1997
    ....
  53. ncbi Critical roles of c-Kit tyrosine residues 567 and 719 in stem cell factor-induced chemotaxis: contribution of src family kinase and PI3-kinase on calcium mobilization and cell migration
    Shuji Ueda
    Department of Hematology and Oncology, and the Department of Microbiology, Osaka University Graduate School of Medicine, Osaka, Japan
    Blood 99:3342-9. 2002
    ..in proliferation, survival, and differentiation of hematopoietic stem cells and mast cells through binding to c-Kit receptor (KIT). Chemotaxis is another unique function of SCF...
  54. ncbi Mast cell-associated TNF promotes dendritic cell migration
    Hajime Suto
    Department of Pathology, Stanford University School of Medicine, CA 94305, USA
    J Immunol 176:4102-12. 2006
    ..We found that CHS to FITC was significantly impaired in mast cell-deficient Kit(W-sh/W-sh) or TNF(-/)(-) mice...
  55. pmc Mast cell-derived TNF can exacerbate mortality during severe bacterial infections in C57BL/6-KitW-sh/W-sh mice
    Adrian M Piliponsky
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Am J Pathol 176:926-38. 2010
    We used mast cell-engrafted genetically mast cell-deficient C57BL/6-Kit(W-sh/W-sh) mice to investigate the roles of mast cells and mast cell-derived tumor necrosis factor in two models of severe bacterial infection...
  56. pmc Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation
    K Ikuta
    Howard Hughes Medical Institute, Stanford University School of Medicine, CA 94305
    Proc Natl Acad Sci U S A 89:1502-6. 1992
    The interaction of the mouse c-kit receptor, designated Kit receptor, and steel factor promotes the proliferation and differentiation of hematopoietic progenitor cells...
  57. ncbi Analyzing mast cell development and function using mice carrying mutations at W/c-kit or Sl/MGF (SCF) loci
    S J Galli
    Department of Pathology, Beth Israel Hospital, Boston, Massachusetts
    Ann N Y Acad Sci 664:69-88. 1992
    ..W/Wv mice have mutations affecting the c-kit tyrosine kinase receptor which is encoded at the W locus and which is necessary for normal mast cell development...
  58. ncbi MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes
    T J Hemesath
    Division of Pediatric Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 391:298-301. 1998
    Germline mutations at loci encoding the transcription factor Microphthalmia (Mi), the cytokine receptor c-Kit, or its ligand Steel factor (S1) result in strikingly similar defects in mast cell and melanocyte development...
  59. pmc Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2
    E J Huang
    Program in Molecular Biology, Sloan Kettering Institute, New York, New York 10021
    Mol Biol Cell 3:349-62. 1992
    The c-kit ligand, KL, and its receptor, the proto-oncogene c-kit are encoded, respectively, at the steel (Sl) and white spotting (W) loci of the mouse...
  60. ncbi c-kit Gene was not transcribed in cultured mast cells of mast cell-deficient Wsh/Wsh mice that have a normal number of erythrocytes and a normal c-kit coding region
    T Tono
    Department of Pathology, Medical School, Osaka University, Suita, Japan
    Blood 80:1448-53. 1992
    The Wsh is a mutant allele at the W (c-kit) locus of mice. Mice of Wsh/Wsh genotype have white hairs and black eyes. Although adult C57BL/6-Wsh/Wsh mice were not anemic, they showed a remarkable depletion of mast cells...
  61. ncbi Incidence and distribution of experimental metastases in mutant mice with defective organ microenvironments (genotypes Sl/Sld and W/Wv)
    F Arguello
    Strong Children s Research Center, University of Rochester School of Medicine, New York 14642
    Cancer Res 52:2304-9. 1992
    Mice carrying mutations at the Sl (steel) and W (dominant white spotting) loci develop abnormalities on 3 migratory embryonic stem cell populations: hematopoietic stem cells, neural crest-derived melanocytes, and primordial germ cells...
  62. ncbi A new family of mouse homeo box-containing genes: molecular structure, chromosomal location, and developmental expression of Hox-7.1
    R E Hill
    Developmental Genetics Group, MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    Genes Dev 3:26-37. 1989
    ..Later, this gene is expressed in regions of the face that are derived from neural crest and in the interdigital mesenchymal tissues in both the fore- and hindlimbs...
  63. ncbi A new allele sash (Wsh) at the W-locus and a spontaneous recessive lethal in mice
    M F Lyon
    Genet Res 39:315-22. 1982
  64. ncbi Mutations at the W locus affect survival of neural crest-derived melanocytes in the mouse
    J Cable
    MRC Institute of Hearing Research, University Park, Nottingham, UK
    Mech Dev 50:139-50. 1995
    The development of melanoblasts in normally pigmented and dominant spotting (W) embryos was followed by in situ hybridisation to TRP-2/DT mRNA, which labels migratory melanoblasts from 10 days post coitum...
  65. ncbi Mast cells modulate allergic pulmonary eosinophilia in mice
    T T Kung
    Schering Plough Research Institute, Kenilworth, New Jersey 07033 0539, USA
    Am J Respir Cell Mol Biol 12:404-9. 1995
    ..On the other hand, levels of serum IgE and IgG1 were not different between W/Wv mice and their congenic littermates.(ABSTRACT TRUNCATED AT 250 WORDS)..
  66. ncbi Activation of the receptor tyrosine kinase Kit is required for the proliferation of melanoblasts in the mouse embryo
    M A MacKenzie
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, EH4 2XU, United Kingdom
    Dev Biol 192:99-107. 1997
    ..as well as haematopoietic and germ cells, is affected by mutations of the Kit and Mgf genes, which lead to dominant spotting (W) or steel (Sl) phenotypes...
  67. ncbi Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites
    C S Lantz
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 392:90-3. 1998
    ..are impaired even more severely in IL-3-deficient mice that also show a marked reduction in signalling by c-kit. These findings establish a role for IL-3 in immunity to parasites and indicate that one of the functions of IL-3 ..
  68. pmc Induction of histidine decarboxylase in skeletal muscle in mice by electrical stimulation, prolonged walking and interleukin-1
    Y Endo
    Department of Pharmacology, School of Dentistry, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai 980
    J Physiol 509:587-98. 1998
    ....
  69. ncbi Altered cell-surface targeting of stem cell factor causes loss of melanocyte precursors in Steel17H mutant mice
    B Wehrle-Haller
    Department of Pathology, Centre Medical Universitaire, 1, rue Michel Servet, Geneva 4, 1211, Switzerland
    Dev Biol 210:71-86. 1999
    The normal products of the murine Steel (Sl) and Dominant white spotting (W) genes are essential for the development of melanocyte precursors, germ cells, and hematopoietic cells...
  70. ncbi Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia
    A Hart
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Immunity 13:167-77. 2000
    ..We map the megakaryocytic defects in 14 Jacobsen patients to a minimal region on 11q that includes the Fli-1 gene and suggest that dysmegakaryopoiesis in these patients may be caused by hemizygous loss of Fli-1...
  71. pmc An allelic series of mutations in the Kit ligand gene of mice. II. Effects of ethylnitrosourea-induced Kitl point mutations on survival and peripheral blood cells of Kitl(Steel) mice
    S Rajaraman
    Department of Genetics, University of Georgia, Athens, Georgia 30602 7223, USA
    Genetics 162:341-53. 2002
    The ligand for the Kit receptor tyrosine kinase is Kit ligand (Kitl; also known as mast cell growth factor, stem cell factor, and Steel factor), which is encoded at the Steel (Sl) locus of mice...
  72. ncbi Tumor necrosis factor-alpha-converting enzyme controls surface expression of c-Kit and survival of embryonic stem cell-derived mast cells
    Anthony C Cruz
    Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
    J Biol Chem 279:5612-20. 2004
    ..Prior work has shown that the receptor tyrosine kinase, c-Kit (CD117), is essential for mast cell survival and that serum levels of c-Kit increase in proliferative mast cell disorders,..
  73. pmc Mast cell dipeptidyl peptidase I mediates survival from sepsis
    Jon Mallen-St Clair
    Department of Medicine and the Cardiovascular Research Institute, University of California, San Francisco, California 94143 0911, USA
    J Clin Invest 113:628-34. 2004
    ..These results indicate that mast cell DPPI harms the septic host and that DPPI is a novel potential therapeutic target for treatment of sepsis...
  74. ncbi PECAM-1 is expressed on hematopoietic stem cells throughout ontogeny and identifies a population of erythroid progenitors
    Christina I Baumann
    Center for Hematologic Malignancies, Division of Hematology and Medical Oncology, Department of Medicine, Oregon Health and Sciences University UHN73C 3181 SW Sam Jackson Park Rd, 97239, USA
    Blood 104:1010-6. 2004
    ..CD31+ c-kit+ cells, but not CD31- c-kit+ cells, isolated from day-9.5 yolk sac give rise to multilineage hematopoiesis in vivo...
  75. ncbi Lack of neurokinin-1 receptor expression affects tissue mast cell numbers but not their spatial relationship with nerves
    Michael R D'Andrea
    Drug Discovery, Johnson and Johnson Pharmaceutical Research and Development, Spring House, Pennsylvania, USA
    Am J Physiol Regul Integr Comp Physiol 288:R491-500. 2005
    ..For this purpose, mast cell-deficient Kit(W)/Kit(W-v) mice were reconstituted with wild-type or NK1-/- bone marrow...
  76. pmc Neutrophil histamine contributes to inflammation in mycoplasma pneumonia
    Xiang Xu
    Cardiovascular Research Institute, Department of Microbiology Immunology, University of California at San Francisco, and Veterans Affairs Medical Center, San Francisco 94121, USA
    J Exp Med 203:2907-17. 2006
    ..These findings suggest that neutrophils, provoked by mycoplasma, greatly expand their capacity to synthesize histamine, thereby contributing to lung and airway inflammation...
  77. pmc Distinct pigmentary and melanocortin 1 receptor-dependent components of cutaneous defense against ultraviolet radiation
    Craig S April
    Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS Genet 3:e9. 2007
    ..Animals without viable melanocytes (Kit(W-v)/Kit(W-v)) or animals lacking a functional Mc1r (Mc1r(e)/Mc1r(e)) were exposed to sunburn-level doses of UVB ..
  78. ncbi The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis
    Ana Olivera
    Molecular Inflammation Section, Molecular Immunology and Inflammation Branch, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 26:287-97. 2007
    ..Thus, sphingosine kinases are determinants of mast cell responsiveness, demonstrating a previously unrecognized relationship with anaphylaxis...
  79. ncbi Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B
    Michele A Grimbaldeston
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5176, USA
    Nat Immunol 8:1095-104. 2007
    ....
  80. ncbi Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia
    Marta Bosch-Marce
    Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Circ Res 101:1310-8. 2007
    ..directly activates transcription of the gene encoding stem cell factor and that mice lacking the cognate receptor C-KIT have impaired recovery from ischemia...
  81. pmc SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia
    Jinke Cheng
    Department of Cardiology, The University of Texas MD Anderson Cancer Center, The University of Texas, Houston Health Science Center, Houston, TX 77030, USA
    Cell 131:584-95. 2007
    ..These results show that SENP1 plays a key role in the regulation of the hypoxic response through regulation of HIF1alpha stability and that SUMOylation can serve as a direct signal for ubiquitin-dependent degradation...
  82. ncbi Gonadal expression of c-kit encoded at the W locus of the mouse
    K Manova
    Department of Cell Biology and Anatomy, Cornell University Medical College, New York, NY 10021
    Development 110:1057-69. 1990
    Recently, it has been shown that the c-kit proto-oncogene is encoded at the white spotting (W) locus in mice. Mutations of this gene cause depletion of germ cells, some hematopoietic cells and melanocytes...
  83. ncbi The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene
    E N Geissler
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Cell 55:185-92. 1988
    ..Mapping experiments suggest that the c-kit proto-oncogene, which encodes a putative tyrosine kinase receptor, is a candidate for the W locus...
  84. ncbi Effects of monoclonal anti-c-kit antibody (ACK2) on melanocytes in newborn mice
    M Okura
    Department of Dermatology, St Marianna University School of Medicine, Kawasaki, Japan
    J Invest Dermatol 105:322-8. 1995
    Previous studies indicate that c-Kit is required for postnatal melanocyte development...
  85. ncbi Expression and function of c-Kit in fetal hemopoietic progenitor cells: transition from the early c-Kit-independent to the late c-Kit-dependent wave of hemopoiesis in the murine embryo
    M Ogawa
    Department of Morphogenesis, Kumamoto University School of Medicine, Japan
    Development 117:1089-98. 1993
    The protooncogene c-kit encodes a receptor type tyrosine kinase and is allelic with the W locus of mice. SLF, the c-Kit ligand which is encoded by the Sl locus, has growth promoting activity for hemopoietic stem cells...
  86. ncbi Long-range genomic rearrangements upstream of Kit dysregulate the developmental pattern of Kit expression in W57 and Wbanded mice and interfere with distinct steps in melanocyte development
    M Kluppel
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Development 124:65-77. 1997
    Mutations in the murine dominant white spotting (W) locus cause pleiotropic developmental defects that affect hematopoietic cells, melanocytes, germ cells and the interstitial cells of Cajal in the gut...
  87. ncbi The control effect of histamine on body temperature and respiratory function in IgE-dependent systemic anaphylaxis
    Yoko Makabe-Kobayashi
    Department of Cellular Pharmacology, Tohoku University Graduate School of Medicine, Seiryo cho 2 1, Aoba ku, Sendai 980 8575, Japan
    J Allergy Clin Immunol 110:298-303. 2002
    ..The systemic anaphylaxis reaction comprises various symptoms, including hypotension, changes in respiration pattern, and hypothermia...
  88. ncbi RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse
    Minoo Rassoulzadegan
    INSERM, U636, F 06108 Nice, France
    Nature 441:469-74. 2006
    ..Here we report a similar modification of the mouse Kit gene in the progeny of heterozygotes with the null mutant Kit(tm1Alf) (a lacZ insertion)...
  89. pmc Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines
    Shafie Fazel
    Division of Cardiovascular Surgery, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Clin Invest 116:1865-77. 2006
    ..We examined the nature of endogenous myocardial repair that is dependent on the function of the c-kit receptor, which is expressed on bone marrow stem/progenitor cells and on recently identified cardiac stem cells...
  90. doi A protective role of mast cells in intestinal tumorigenesis
    Mark J Sinnamon
    Department of Cancer Biology, Vanderbilt University, 771 PRB 23rd and Pierce Avenue Nashville, TN 37232 6840, USA
    Carcinogenesis 29:880-6. 2008
    ..the role of mast cells in intestinal tumorigenesis, a mutant mouse line deficient in mast cells, Sash mice (c-kit(W-sh/W-sh)), was crossed with the Min mouse, a genetic model of intestinal neoplasia...
  91. doi Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis
    Yusuke Tsujimura
    Department of Immune Regulation and Tokyo Medical and Dental University Graduate School, Tokyo 113 8519, Japan
    Immunity 28:581-9. 2008
    ....
  92. ncbi Decreased production of mast cells in S1/S1d anemic mice
    Y Kitamura
    Blood 53:492-7. 1979
  93. ncbi Capacity of adult steel (SI/SId) and dominant spotting (W/Wv) mouse skin to support melanogenesis
    T W Poole
    Dev Biol 72:398-400. 1979
  94. ncbi The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus
    E Huang
    Molecular Biology Program, Sloan Kettering Institute, New York, New York
    Cell 63:225-33. 1990
    ..mouse affect the same cellular targets as mutations at the white spotting locus (W), which is allelic with the c-kit proto-oncogene...
  95. ncbi Developmental expression of c-kit, a proto-oncogene encoded by the W locus
    A Orr-Urtreger
    Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel
    Development 109:911-23. 1990
    Developmental expression of the c-kit proto-oncogene, a receptor tyrosine kinase encoded by the W locus, was investigated by in situ hybridization in normal mouse embryos...
  96. pmc Embryonic RNA expression patterns of the c-kit receptor and its cognate ligand suggest multiple functional roles in mouse development
    E Keshet
    Mammalian Genetics Laboratory, ABL Basic Research Program, NCI FCRDC, Frederick, MD 21702 1201
    EMBO J 10:2425-35. 1991
    Mutations at the dominant white spotting (W) and Steel (Sl) loci in mouse exert deleterious effects on three migratory cell lineages (primordial germ cells, melanocytes and hematopoietic stem cells) resulting in loss of pigmentation, ..
  97. ncbi The murine W/c-kit and Steel loci and the control of hematopoiesis
    A Bernstein
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canda
    Semin Hematol 28:138-42. 1991
    The experiments summarized here indicate that germ-line mutations in either the c-kit receptor tyrosine kinase (W mutants) or its ligand (Sl) lead to profound and pleiotropic developmental defects, including abnormalities within the ..
  98. ncbi The kit ligand encoded at the murine Steel locus: a pleiotropic growth and differentiation factor
    P Besmer
    Sloan Kettering Institute, New York
    Curr Opin Cell Biol 3:939-46. 1991
    The c-kit receptor and its recently identified ligand are allelic with the murine White Spotting and Steel loci, respectively...
  99. ncbi An analysis of mast cell frequency in the rodent nervous system: numbers vary between different strains and can be reconstituted in mast cell-deficient mice
    D Johnson
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115
    J Neuropathol Exp Neurol 50:227-34. 1991
    ....
  100. ncbi Steel factor and c-kit regulate cell-matrix adhesion
    T Kinashi
    Center for Blood Research, Boston, MA 02115
    Blood 83:1033-8. 1994
    Steel (SI) and white spotting (W) loci encode steel factor (c-kit ligand) and the c-kit tyrosine kinase receptor, respectively...
  101. ncbi Effects of mutations at the W locus (c-kit) on inner ear pigmentation and function in the mouse
    J Cable
    MRC Institute of Hearing Research, University Park, Nottingham, U K
    Pigment Cell Res 7:17-32. 1994
    ..The primary cochlear defect in Viable Dominant Spotting (Wv/Wv) mutants is a lack of melanocytes within the stria vascularis (SV) associated with an endocochlear ..

Research Grants22

  1. Chemoprevention of IBD-Associated Colon Cancer
    Laura P Hale; Fiscal Year: 2010
    ..The proposed studies will further elucidate mechanisms that can lead to novel interventions to prevent IBD-associated colon cancers, providing great benefit to IBD patients and their families. ..
  2. Inflammatory mediators and UV-induced carcinogenesis
    Stephen Ullrich; Fiscal Year: 2009
    ..The focus of the studies presented here is to provide evidence to support the hypothesis that these drugs can act as novel agents to prevent skin cancer formation. ..
  3. Genetic remodeling of Vagal Afferent Organization
    Edward Fox; Fiscal Year: 2009
    ..Moreover, it will form an essential foundation for further research on the development of, and the structural and functional organization of, the diverse systems that form the vagal sensorium. ..
  4. Keratinocyte-derived immuno-suppressive cytokines
    Stephen Ullrich; Fiscal Year: 2005
    ..A better understanding of the mechanisms involved may help with the design of rational approaches to block the induction of immune suppression, thereby reducing one of the major risk factors for skin cancer induction. ..
  5. IN UTERO STEM CELL TRANSFER IN MPS VII
    Brian Soper; Fiscal Year: 2005
    ..abstract_text> ..
  6. Do NKT cells mediate UV induced Immune Suppression?
    Stephen Ullrich; Fiscal Year: 2005
    ..A better understanding of the mechanisms involved in UV-induced immune suppression may help with the design of rational approaches to block immune suppression, thereby reducing one of the major risk factors for skin cancer induction. ..
  7. Novel Oral Adjuvant for Dental Vaccines
    LAURA HALE; Fiscal Year: 2005
    ..abstract_text> ..
  8. Mast Cells and IBD Pathogenesis
    LAURA HALE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  9. Bromelain as a Biologically-Based Therapy for IBD
    LAURA HALE; Fiscal Year: 2005
    ..This research will thus strengthen the biomedical research knowledge base needed to inform the practice of complementary and alternative medicine. ..
  10. Bromelain Proteinase Activity in IBD
    LAURA HALE; Fiscal Year: 2006
    ..They will thus strengthen the scientific knowledge base needed to inform the practice of complementary and alternative medicine. ..
  11. VIP-induced gene expression in colonic smooth muscle cells
    Sushil K Sarna; Fiscal Year: 2010
    ..abstract_text> ..
  12. ESTROGEN METABOLITES EFFECTS ON BONE
    Russell Turner; Fiscal Year: 2002
    ..abstract_text> ..
  13. Ras-PI3K Pathway in Nf1-/-Hematopoiesis and Leukemia
    David Ingram; Fiscal Year: 2007
    ..abstract_text> ..
  14. Protein Therapy for Junctional Epidermolysis Bullosa
    Vitali Alexeev; Fiscal Year: 2006
    ..abstract_text> ..
  15. Genetics of Dark Skin in Mice
    Gregory Barsh; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  16. DOSE RESPONSE EFFECTS OF ALCOHOL ON BONE METABOLISM
    Russell Turner; Fiscal Year: 2006
    ....
  17. CHARACTERIZATION AND TREATMENT OF MURINE MPS VII
    Brian Soper; Fiscal Year: 2006
    ..Differentiation capacity will be compared to directly brain implanted SC. Behavioral studies will determine long-term neurological function. ..
  18. Etiology and Treatment of Parathyroid Bone Disease
    Russell Turner; Fiscal Year: 2005
    ..Since PDGF antagonists such as trapidil are available for human use, positive results could be quickly extended to clinical practice. ..
  19. FRZB PROFILES AS OSTEOARTHRITIS BIOMARKERS
    MARY CORR; Fiscal Year: 2004
    ..The results of these studies will both contribute to, and will utilize, the resources of the OA biomarker consortium. ..
  20. Attractin and Mahoganoid in Spongy Neurodegeneration
    Gregory Barsh; Fiscal Year: 2007
    ..Investigating the biochemical, cellular, and genetic relationships between Atrn, Mahoganoid, and PrP is likely to provide general insight into the pathogenesis of spongy degeneration. [unreadable] [unreadable]..
  21. REGULATION OF ENERGY BALANCE BY MELANOCORTIN ANTAGONISTS
    Gregory Barsh; Fiscal Year: 2003
    ..abstract_text> ..