Kif4

Summary

Gene Symbol: Kif4
Description: kinesin family member 4
Alias: AI323435, D330050K22Rik, Kns4, chromosome-associated kinesin KIF4, N-5 kinesin, chromokinesin, kinesin heavy chain member 4
Species: mouse

Top Publications

  1. pmc A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally
    Y Sekine
    Department of Anatomy and Cell Biology, School of Medicine, University of Tokyo, Japan
    J Cell Biol 127:187-201. 1994
  2. pmc Binding of murine leukemia virus Gag polyproteins to KIF4, a microtubule-based motor protein
    W Kim
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    J Virol 72:6898-901. 1998
  3. pmc KIF4 mediates anterograde translocation and positioning of ribosomal constituents to axons
    Mariano Bisbal
    Laboratory of Neurobiology and Cell Biology, Instituto Investigación Médica Mercedes y Martín Ferreyra Consejo Nacional de Investigaciones Científicas y Técnicas, 5016 Cordoba, Argentina
    J Biol Chem 284:9489-97. 2009
  4. pmc KIF4 regulates midzone length during cytokinesis
    Chi Kuo Hu
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Curr Biol 21:815-24. 2011
  5. doi Characterization of nuclear factors modulating the apolipoprotein D promoter during growth arrest: implication of PARP-1, APEX-1 and ERK1/2 catalytic activities
    Louis Charles Levros
    Laboratoire de Biologie Moleculaire, Departement des Sciences Biologiques, and Centre BioMed, Universite du Quebec a Montreal, Montreal, Quebec, Canada
    Biochim Biophys Acta 1803:1062-71. 2010
  6. pmc Kif4 interacts with EB1 and stabilizes microtubules downstream of Rho-mDia in migrating fibroblasts
    Edward J Morris
    Department of Pathology and Cell Biology, Columbia University, New York, New York, United States of America
    PLoS ONE 9:e91568. 2014
  7. doi Unusual chromatin status and organization of the inactive X chromosome in murine trophoblast giant cells
    Catherine Corbel
    Unité de génétique et biologie du développement, Institut Curie, CNRS UMR 3215, INSERM U934, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Development 140:861-72. 2013
  8. doi Structural basis for the ATP-induced isomerization of kinesin
    Qing Chang
    Department of Cell Biology and Anatomy, Graduate School of Medicine, The University of Tokyo, Hongo, Tokyo 113 0033, Japan
    J Mol Biol 425:1869-80. 2013
  9. pmc Kinesin family in murine central nervous system
    H Aizawa
    Department of Anatomy and Cell Biology, School of Medicine, University of Tokyo, Japan
    J Cell Biol 119:1287-96. 1992
  10. ncbi Genetic mapping in the mouse of Kif4, a gene encoding a kinesin-like motor protein
    M S Lyu
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 329, Bethesda, Maryland 20892 0460, USA
    Mamm Genome 8:541. 1997

Scientific Experts

  • Chi Kuo Hu
  • Catherine Corbel
  • Manjari Mazumdar
  • Edward J Morris
  • Qing Chang
  • Louis Charles Levros
  • Nobutaka Hirokawa
  • Mariano Bisbal
  • W Kim
  • Ryosuke Midorikawa
  • H C Morse
  • Francesca Bartolini
  • Gregg G Gundersen
  • Guilherme P F Nader
  • Nagendran Ramalingam
  • Shigeyuki Inoue
  • Ryo Nitta
  • Cyndia Charfi
  • Sonia Do Carmo
  • S Oh
  • Eric Rassart
  • Elsy Edouard
  • Philippe Legault
  • José Wojnacki
  • Andrea Ropolo
  • Juliana Sesma
  • Diego Peretti
  • Alfredo Caceres
  • Ignacio Jausoro
  • T A Torrey
  • W Choi
  • Yosuke Takei
  • N Hirokawa
  • M S Lyu
  • Y Okada
  • Y Sekine
  • H Shin
  • Y M Lee
  • H Hahn
  • F G Falkner
  • S K Chattopadhyay
  • Y Tang
  • F Dorner
  • H Aizawa
  • M Pfleiderer
  • C A Kozak
  • R Takemura
  • Y Noda
  • S Kondo
  • M Nangaku
  • Z Zhang

Detail Information

Publications13

  1. pmc A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally
    Y Sekine
    Department of Anatomy and Cell Biology, School of Medicine, University of Tokyo, Japan
    J Cell Biol 127:187-201. 1994
    To understand the mechanisms of transport for organelles in the axon, we isolated and sequenced the cDNA encoding KIF4 from murine brain, and characterized the molecule biochemically and immunocytochemically...
  2. pmc Binding of murine leukemia virus Gag polyproteins to KIF4, a microtubule-based motor protein
    W Kim
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA
    J Virol 72:6898-901. 1998
    ..The sequence of the clone is identical to the C terminus of a cellular protein, KIF4, a microtubule-associated motor protein that belongs to the kinesin superfamily...
  3. pmc KIF4 mediates anterograde translocation and positioning of ribosomal constituents to axons
    Mariano Bisbal
    Laboratory of Neurobiology and Cell Biology, Instituto Investigación Médica Mercedes y Martín Ferreyra Consejo Nacional de Investigaciones Científicas y Técnicas, 5016 Cordoba, Argentina
    J Biol Chem 284:9489-97. 2009
    ..a combination of biochemical and molecular biology techniques to demonstrate that the C-terminal tail domain of KIF4 directly interacts with P0, a major protein component of ribosomes...
  4. pmc KIF4 regulates midzone length during cytokinesis
    Chi Kuo Hu
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Curr Biol 21:815-24. 2011
    ..Investigating midzone microtubule dynamics has been difficult in part because their plus ends are interdigitated and buried in a dense matrix, making them difficult to observe...
  5. doi Characterization of nuclear factors modulating the apolipoprotein D promoter during growth arrest: implication of PARP-1, APEX-1 and ERK1/2 catalytic activities
    Louis Charles Levros
    Laboratoire de Biologie Moleculaire, Departement des Sciences Biologiques, and Centre BioMed, Universite du Quebec a Montreal, Montreal, Quebec, Canada
    Biochim Biophys Acta 1803:1062-71. 2010
    ..In this study, we show that Parp-1, HnRNP-U, CBF-A, BUB-3, Kif4, APEX-1 and Ifi204 bind these regulatory elements of the apoD promoter...
  6. pmc Kif4 interacts with EB1 and stabilizes microtubules downstream of Rho-mDia in migrating fibroblasts
    Edward J Morris
    Department of Pathology and Cell Biology, Columbia University, New York, New York, United States of America
    PLoS ONE 9:e91568. 2014
    ..Here, we show that the mammalian homolog of Xenopus XKLP1, Kif4, is both necessary and sufficient for the induction of selective MT stabilization in fibroblasts...
  7. doi Unusual chromatin status and organization of the inactive X chromosome in murine trophoblast giant cells
    Catherine Corbel
    Unité de génétique et biologie du développement, Institut Curie, CNRS UMR 3215, INSERM U934, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Development 140:861-72. 2013
    ..This unusual combination of silent and active features is likely to reflect, and might underlie, the partial activity of the X chromosome in TGCs...
  8. doi Structural basis for the ATP-induced isomerization of kinesin
    Qing Chang
    Department of Cell Biology and Anatomy, Graduate School of Medicine, The University of Tokyo, Hongo, Tokyo 113 0033, Japan
    J Mol Biol 425:1869-80. 2013
    ..Here, we report the first crystal structure of KIF4 complexed with the non-hydrolyzable ATP analog, AMPPNP (adenylyl imidodiphosphate), at 1.7Å resolution...
  9. pmc Kinesin family in murine central nervous system
    H Aizawa
    Department of Anatomy and Cell Biology, School of Medicine, University of Tokyo, Japan
    J Cell Biol 119:1287-96. 1992
    ..that KIF1 and KIF5 are murine counterparts of unc104 and kinesin heavy chain, respectively, while KIF2, KIF3, and KIF4 are as yet unidentified new species...
  10. ncbi Genetic mapping in the mouse of Kif4, a gene encoding a kinesin-like motor protein
    M S Lyu
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 329, Bethesda, Maryland 20892 0460, USA
    Mamm Genome 8:541. 1997
  11. ncbi Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein
    S Oh
    Institute for Medical Sciences, Ajou University, Suwon 442 749, South Korea
    Biochim Biophys Acta 1493:219-24. 2000
    A combination of RT-PCR with cDNA library screening led to the identification of the human homologue of murine KIF4 (mKIF4), a microtubule-based motor protein...
  12. ncbi KIF4 motor regulates activity-dependent neuronal survival by suppressing PARP-1 enzymatic activity
    Ryosuke Midorikawa
    Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Tokyo 113 0033, Japan
    Cell 125:371-83. 2006
    ..the activity-dependent prevention of apoptosis in juvenile neurons is regulated by kinesin superfamily protein 4 (KIF4), a microtubule-based molecular motor...
  13. pmc Tumor formation via loss of a molecular motor protein
    Manjari Mazumdar
    National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Curr Biol 16:1559-64. 2006
    ..The chromosome-associated kinesin motor KIF4 plays multiple roles in mitosis, and its loss leads to multiple mitotic defects including aneuploidy...