Ki67

Summary

Gene Symbol: Ki67
Description: antigen identified by monoclonal antibody Ki 67
Alias: D630048A14Rik, Ki-67, Ki67, proliferation marker protein Ki-67, antigen KI-67, antigen KI-67 homolog, antigen Ki67 homolog, antigen identified by monoclonal antibody Ki-67 homolog
Species: mouse

Top Publications

  1. doi The tumor suppressor Pml regulates cell fate in the developing neocortex
    Tarik Regad
    Medicial Research Council Toxicology Unit, University of Leicester, Box 138 Lancaster Road, Leicester LE1 7JL, UK
    Nat Neurosci 12:132-40. 2009
  2. ncbi Microglia proliferation is controlled by P2X7 receptors in a Pannexin-1-independent manner during early embryonic spinal cord invasion
    Chiara Rigato
    Institut National de la Sante et de la Recherche Medicale, U952, Universite Pierre et Marie Curie, Paris, Ile de France, France
    J Neurosci 32:11559-73. 2012
  3. pmc Retinoic acid from the meninges regulates cortical neuron generation
    Julie A Siegenthaler
    Department of Neurology, Institute for Regenerative Medicine, University of California San Francisco, San Francisco, CA 94158, USA
    Cell 139:597-609. 2009
  4. pmc Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression
    Gerda Lagger
    Institute of Medical Biochemistry, Division of Molecular Biology, University of Vienna, Vienna Biocenter, Dr Bohr Gasse 9 2, A 1030 Vienna, Austria
    EMBO J 21:2672-81. 2002
  5. doi Neurogenin 2 has an essential role in development of the dentate gyrus
    Christophe Galichet
    Division of Molecular Neurobiology, National Institute of Medical Research, The Ridgeway, Mill Hill, NW7 1AA London, UK
    Development 135:2031-41. 2008
  6. pmc Different timings of Dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system
    Yoko Kawase-Koga
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York 10065, USA
    Dev Dyn 238:2800-12. 2009
  7. pmc RNAase-III enzyme Dicer maintains signaling pathways for differentiation and survival in mouse cortical neural stem cells
    Yoko Kawase-Koga
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, Box 60, New York, NY 10065, USA
    J Cell Sci 123:586-94. 2010
  8. ncbi Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
    V Korinek
    Department of Immunology, University Hospital, Utrecht, The Netherlands
    Nat Genet 19:379-83. 1998
  9. ncbi A role for Gsh1 in the developing striatum and olfactory bulb of Gsh2 mutant mice
    H Toresson
    Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, Solvegatan 17, BMC A11, S 221 84 Lund, Sweden
    Development 128:4769-80. 2001
  10. ncbi Origin and characteristics of glycogen cells in the developing murine placenta
    P M Coan
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing Street, Cambridge, United Kingdom
    Dev Dyn 235:3280-94. 2006

Research Grants

Detail Information

Publications164 found, 100 shown here

  1. doi The tumor suppressor Pml regulates cell fate in the developing neocortex
    Tarik Regad
    Medicial Research Council Toxicology Unit, University of Leicester, Box 138 Lancaster Road, Leicester LE1 7JL, UK
    Nat Neurosci 12:132-40. 2009
    ..Together, these findings reveal an unexpected role of Pml in controlling the function of NPCs in the CNS...
  2. ncbi Microglia proliferation is controlled by P2X7 receptors in a Pannexin-1-independent manner during early embryonic spinal cord invasion
    Chiara Rigato
    Institut National de la Sante et de la Recherche Medicale, U952, Universite Pierre et Marie Curie, Paris, Ile de France, France
    J Neurosci 32:11559-73. 2012
    ..These results reveal a developmental role of P2X7R by controlling embryonic SC microglia proliferation at a critical developmental state in the SC of mouse embryos...
  3. pmc Retinoic acid from the meninges regulates cortical neuron generation
    Julie A Siegenthaler
    Department of Neurology, Institute for Regenerative Medicine, University of California San Francisco, San Francisco, CA 94158, USA
    Cell 139:597-609. 2009
    ..Lastly, in utero RA treatment rescued the cortical phenotype in Foxc1 mutants. These results establish RA as a potent, meningeal-derived cue required for successful corticogenesis...
  4. pmc Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression
    Gerda Lagger
    Institute of Medical Biochemistry, Division of Molecular Biology, University of Vienna, Vienna Biocenter, Dr Bohr Gasse 9 2, A 1030 Vienna, Austria
    EMBO J 21:2672-81. 2002
    ..Our study provides the first evidence that a histone deacetylase is essential for unrestricted cell proliferation by repressing the expression of selective cell cycle inhibitors...
  5. doi Neurogenin 2 has an essential role in development of the dentate gyrus
    Christophe Galichet
    Division of Molecular Neurobiology, National Institute of Medical Research, The Ridgeway, Mill Hill, NW7 1AA London, UK
    Development 135:2031-41. 2008
    ..These data establish a unique role of Ngn2 in DG neurogenesis during development and raise the possibility that Ngn2 has a similar function in adult neurogenesis...
  6. pmc Different timings of Dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system
    Yoko Kawase-Koga
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York 10065, USA
    Dev Dyn 238:2800-12. 2009
    ..Our studies of different timings of Dicer deletion demonstrate the importance of the Dicer-mediated microRNA pathway in regulating distinct phases of neurogenesis and gliogenesis during the CNS development...
  7. pmc RNAase-III enzyme Dicer maintains signaling pathways for differentiation and survival in mouse cortical neural stem cells
    Yoko Kawase-Koga
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, Box 60, New York, NY 10065, USA
    J Cell Sci 123:586-94. 2010
    ..Our results demonstrate important functions for Dicer in regulating NSC development by maintaining proper signaling pathways related to cell survival and differentiation...
  8. ncbi Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
    V Korinek
    Department of Immunology, University Hospital, Utrecht, The Netherlands
    Nat Genet 19:379-83. 1998
    ..The constitutive activity of Tcf-4 in APC-deficient human epithelial cells may contribute to their malignant transformation by maintaining stem-cell characteristics...
  9. ncbi A role for Gsh1 in the developing striatum and olfactory bulb of Gsh2 mutant mice
    H Toresson
    Wallenberg Neuroscience Center, Division of Neurobiology, Lund University, Solvegatan 17, BMC A11, S 221 84 Lund, Sweden
    Development 128:4769-80. 2001
    ....
  10. ncbi Origin and characteristics of glycogen cells in the developing murine placenta
    P M Coan
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing Street, Cambridge, United Kingdom
    Dev Dyn 235:3280-94. 2006
    ..Thus stereology and immunohistochemistry have provided useful insights into Jz development and function of the glycogen cells...
  11. pmc Mouse atonal homolog 1 directs intestinal progenitors to secretory cell rather than absorptive cell fate
    Kelli L VanDussen
    Department of Molecular and Integrative Physiology, The University of Michigan, Ann Arbor, MI 48109, USA
    Dev Biol 346:215-23. 2010
    ..Moreover, Math1 expression inhibited epithelial cell proliferation, as demonstrated by a marked reduction in Ki67 positive cells and blunted villi...
  12. pmc Basement membrane deposition of nidogen 1 but not nidogen 2 requires the nidogen binding module of the laminin gamma1 chain
    Sharada Mokkapati
    Department of Dermatology, University Hospital of Cologne, 50937 Cologne, Germany
    J Biol Chem 286:1911-8. 2011
    ....
  13. ncbi Matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development
    R Szabo
    Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Oncogene 26:1546-56. 2007
    ..Furthermore, matriptase/HAI-1 double-deficient mice were phenotypically indistinguishable from matriptase single-deficient littermates...
  14. doi Lgr5 marks cycling, yet long-lived, hair follicle stem cells
    Viljar Jaks
    Karolinska Institutet, Department of Biosciences and Nutrition, Novum, SE 141 57 Huddinge, Sweden
    Nat Genet 40:1291-9. 2008
    ..Expression analysis suggests involvement of autocrine Hedgehog signaling in maintaining the Lgr5(+) stem cell population...
  15. pmc Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression
    Masaki Ieda
    Cardiopulmonary Division, Department of Internal Medicine, Keio University School of Medicine, Tookyo, Japan
    J Clin Invest 113:876-84. 2004
    ..These findings indicate that endothelin-1 regulates NGF expression in cardiomyocytes and plays a critical role in sympathetic innervation of the heart...
  16. ncbi MicroRNA expression is required for pancreatic islet cell genesis in the mouse
    Francis C Lynn
    Diabetes Center, Hormone Research Institute, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0534, USA
    Diabetes 56:2938-45. 2007
    ..We tested the hypothesis that microRNAs (miRNAs), which limit gene expression through posttranscriptional silencing, modulate the gene expression cascades involved in pancreas development...
  17. pmc TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling
    Hideki Sanjo
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565 0871, Japan
    Mol Cell Biol 23:1231-8. 2003
    ..These findings demonstrate that TAB2 is essential for embryonic development through prevention of liver apoptosis but not for the IL-1 receptor-mediated signaling pathway...
  18. pmc A role for FE65 in controlling GnRH-1 neurogenesis
    Paolo E Forni
    Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 31:480-91. 2011
    ....
  19. pmc cAMP response element binding protein is required for differentiation of respiratory epithelium during murine development
    A Daniel Bird
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    PLoS ONE 6:e17843. 2011
    ..Together, these results demonstrate a crucial role for Creb1 activity for the development and differentiation of the conducting and distal lung epithelium...
  20. ncbi Wnt signalling induces maturation of Paneth cells in intestinal crypts
    Johan H van Es
    Hubrecht Institute, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
    Nat Cell Biol 7:381-6. 2005
    ..These observations imply that Wnt signals in the crypt can separately drive a stem-cell/progenitor gene programme and a Paneth-cell maturation programme. In intestinal cancer, both gene programmes are activated simultaneously...
  21. pmc Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland
    Valerie Horsley
    Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Cell 126:597-609. 2006
    ....
  22. pmc Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung
    Ahmed H K El-Hashash
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Childrens Hospital Los Angeles, Keck School of Medicine of University of Southern California, 4650 Sunset Boulevard MS35, Los Angeles, CA 90027, USA
    Dev Biol 350:112-26. 2011
    ..We conclude, therefore, that Eya1 function is critical for proper coordination of lung epithelial, mesenchymal and vascular development...
  23. pmc Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferation
    Marion A Cooley
    Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina 29425 2204, USA
    Dev Dyn 241:303-14. 2012
    ..Here we investigated the involvement of fibulin-1 in ADAMTS1-mediated cleavage of versican in vitro, and the involvement of fibulin-1 in versican cleavage in ventricular morphogenesis...
  24. doi Chondroitin sulfate synthase 1 (Chsy1) is required for bone development and digit patterning
    Deanna G Wilson
    Genentech, South San Francisco, CA 94080, USA
    Dev Biol 363:413-25. 2012
    ..Our results place Chsy1 as an essential regulator of joint patterning and provide a mouse model of human brachydactylies caused by mutations in CHSY1...
  25. ncbi Limb and skin abnormalities in mice lacking IKKalpha
    K Takeda
    Department of Biochemistry and Core Research for Evolutional Science and Technology CREST, Japan Science and Technology Corporation, Department of Pathology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Science 284:313-6. 1999
    ....
  26. pmc The role of Axin2 in calvarial morphogenesis and craniosynostosis
    Hsiao Man Ivy Yu
    Center for Oral Biology, Department of Biomedical Genetics, Abs Institute of Biomedical Sciences, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Development 132:1995-2005. 2005
    ..The craniofacial anomalies caused by the Axin2 mutation are mediated through activation of beta-catenin signaling, suggesting a novel role for the Wnt pathway in skull morphogenesis...
  27. ncbi Lim1 is essential for the correct laminar positioning of retinal horizontal cells
    Ross A Poche
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 27:14099-107. 2007
    ..This study is the first to describe a cell type-specific genetic program that is essential for targeting a discrete retinal neuron population to the proper lamina...
  28. pmc Secreted frizzled related protein 1 is a paracrine modulator of epithelial branching morphogenesis, proliferation, and secretory gene expression in the prostate
    Margaret S Joesting
    Department of Genetics, Cellular Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Dev Biol 317:161-73. 2008
    ....
  29. pmc Defect of hepatocyte growth factor activator inhibitor type 1/serine protease inhibitor, Kunitz type 1 (Hai-1/Spint1) leads to ichthyosis-like condition and abnormal hair development in mice
    Koki Nagaike
    Department of Pathology, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki 889 1692, Japan
    Am J Pathol 173:1464-75. 2008
    ..These findings indicate that Hai-1/Spint1 has critical roles in the regulated keratinization of the epidermis and hair development...
  30. doi Stem cell marker aldehyde dehydrogenase 1-positive breast cancers are characterized by negative estrogen receptor, positive human epidermal growth factor receptor type 2, and high Ki67 expression
    Koji Morimoto
    Department of Breast and Endocrine Surgery, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan
    Cancer Sci 100:1062-8. 2009
    ..the distribution of ALDH1+ tumor cells was compared on a cell-by-cell basis with that of estrogen receptor (ER)+, Ki67+, or human epidermal growth factor receptor type 2 (HER2)+ tumor cells by means of double immunohistochemical ..
  31. pmc Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain
    John Jacob
    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 136:2477-85. 2009
    ..Thus, Insm1 regulates the synthesis of distinct monoaminergic neurotransmitters by acting combinatorially with, or independently of, Ascl1 in specific monoaminergic populations...
  32. pmc Deletion of Pten expands lung epithelial progenitor pools and confers resistance to airway injury
    Caterina Tiozzo
    Department of Pediatrics, Division of Neonatology, Women s and Children s Hospital, USC Keck School of Medicine
    Am J Respir Crit Care Med 180:701-12. 2009
    ..In mouse, Pten expression is ubiquitous and begins as early as 7 days of gestation. Pten(-/-) mouse embryos die early during gestation indicating a critical role for Pten in embryonic development...
  33. pmc Inactivation of Dicer1 in Steroidogenic factor 1-positive cells reveals tissue-specific requirement for Dicer1 in adrenal, testis, and ovary
    Chen Che J Huang
    Department of Veterinary Biosciences, University of Illinois, Urbana, IL, USA
    BMC Dev Biol 10:66. 2010
    ..Mouse embryos lacking Dicer1 die in early embryogenesis. In this study, we investigated whether Dicer1 is required for development of adrenal, testis, and ovary in mouse embryos...
  34. ncbi A mouse homologue of Drosophila pins can asymmetrically localize and substitute for pins function in Drosophila neuroblasts
    Fengwei Yu
    Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609
    J Cell Sci 116:887-96. 2003
    ..We further show that Pins can fulfill all aspects of pins function in Drosophila neuroblast asymmetric cell divisions. Our results suggest a conservation of function between the fly and mammalian Pins homologues...
  35. pmc Pdk1 activity controls proliferation, survival, and growth of developing pancreatic cells
    Joby J Westmoreland
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Dev Biol 334:285-98. 2009
    ....
  36. pmc Expression patterns of astrocyte elevated gene-1 (AEG-1) during development of the mouse embryo
    Hyun Yong Jeon
    Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Gene Expr Patterns 10:361-7. 2010
    ....
  37. ncbi Dlx2 progenitor migration in wild type and Nkx2.1 mutant telencephalon
    Susana Nery
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
    Cereb Cortex 13:895-903. 2003
    ..This recovery may be, at least in part, a result of the late migration of Dlx2 progenitors from the caudal ganglionic eminences (CGE), which, based on our previous work, does not appear to require Nkx2.1 gene function...
  38. pmc AML1/Runx1 is important for the development of hindbrain cholinergic branchiovisceral motor neurons and selected cranial sensory neurons
    Francesca M Theriault
    Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, QC, Canada H3A 2B4
    Proc Natl Acad Sci U S A 101:10343-8. 2004
    ..Runx1 inactivation also leads to a loss of selected sensory neurons in trigeminal and vestibulocochlear ganglia. These findings uncover previously unrecognized roles for Runx1 in the regulation of mammalian neuronal subtype development...
  39. pmc Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is required for branching morphogenesis in the chorioallantoic placenta
    Hiroyuki Tanaka
    Second Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Mol Cell Biol 25:5687-98. 2005
    ..Our results indicate that mouse HAI-1 is essential for branching morphogenesis in the chorioallantoic placenta and lack of HAI-1 function may result in placental failure...
  40. pmc Antagonistic effects of Grg6 and Groucho/TLE on the transcription repression activity of brain factor 1/FoxG1 and cortical neuron differentiation
    Nathalie Marcal
    Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Mol Cell Biol 25:10916-29. 2005
    ..Conversely, Grg6 knockdown by RNA interference causes decreased neurogenesis. These results identify a new role for Grg6 in cortical neuron development and establish a functional link between Grg6 and BF-1...
  41. pmc Essential role of B-Raf in ERK activation during extraembryonic development
    Gergana Galabova-Kovacs
    Max F Perutz Laboratories, Vienna Biocenter, Dr Bohr Gasse 9, 1030 Vienna, Austria
    Proc Natl Acad Sci U S A 103:1325-30. 2006
    ..The data demonstrate that B-Raf plays a nonredundant role in ERK activation during extraembyronic mammalian development in vivo...
  42. ncbi SSEA-1 marks regionally restricted immature subpopulations of embryonic retinal progenitor cells that are regulated by the Wnt signaling pathway
    Hideto Koso
    Department of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Dev Biol 292:265-76. 2006
    ..FACS analysis showed that the cells strongly positive for SSEA-1 co-expressed Ki67 proliferation antigen in all the developmental stages examined...
  43. pmc SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia
    Jinke Cheng
    Department of Cardiology, The University of Texas MD Anderson Cancer Center, The University of Texas, Houston Health Science Center, Houston, TX 77030, USA
    Cell 131:584-95. 2007
    ..These results show that SENP1 plays a key role in the regulation of the hypoxic response through regulation of HIF1alpha stability and that SUMOylation can serve as a direct signal for ubiquitin-dependent degradation...
  44. pmc Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation
    Liqin Zhu
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
    Nature 457:603-7. 2009
    ..Our data indicate that Prom1 marks stem cells in the adult small intestine that are susceptible to transformation into tumours retaining a fraction of mutant Prom1(+) tumour cells...
  45. ncbi Sonic hedgehog signaling is essential for hair development
    B St-Jacques
    Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Curr Biol 8:1058-68. 1998
    ..To address the role of Shh in the hair follicle, we have examined Shh null mutant mice...
  46. ncbi Genetic control of dorsal-ventral identity in the telencephalon: opposing roles for Pax6 and Gsh2
    H Toresson
    Wallenberg Neuroscience Center, Division of Neurobiology, Section for Developmental Neurobiology, Lund University, Solvegatan 17, S 223 62 Lund, Sweden
    Development 127:4361-71. 2000
    ....
  47. ncbi Characterization of CNS precursor subtypes and radial glia
    E Hartfuss
    Max Planck Institute of Neurobiology, Am Klopferspitz 18a, Martinsried, D 82152, Germany
    Dev Biol 229:15-30. 2001
    ..Taken together, we have identified novel, functionally distinct subsets of CNS precursor cells...
  48. ncbi Requirement of Math1 for secretory cell lineage commitment in the mouse intestine
    Q Yang
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Science 294:2155-8. 2001
    ..The continuous rapid renewal of these cells makes the intestinal epithelium a model system for the study of stem cell regeneration and lineage commitment...
  49. ncbi Disruption of CREB function in brain leads to neurodegeneration
    Theo Mantamadiotis
    Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Nat Genet 31:47-54. 2002
    ..The striatal phenotype is reminiscent of Huntington disease and is consistent with the postulated role of CREB-mediated signaling in polyglutamine-triggered diseases...
  50. pmc A mutant receptor tyrosine phosphatase, CD148, causes defects in vascular development
    Takamune Takahashi
    Nephrology Division and Center for Vascular Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Mol Cell Biol 23:1817-31. 2003
    ..These findings implicate a member of the receptor tyrosine phosphatase family, CD148, in developmental vascular organization and provide evidence that it regulates endothelial proliferation and endothelium-pericyte interactions...
  51. pmc Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA
    Krzysztof Kobielak
    Howard Hughes Medical Institute and Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021 6399, USA
    J Cell Biol 163:609-23. 2003
    ....
  52. ncbi Expression of the proliferation marker Ki-67 during early mouse development
    H Winking
    Institut fur Biologie, Universitat Lubeck, Lubeck, Germany
    Cytogenet Genome Res 105:251-6. 2004
    ....
  53. ncbi Mitotic spindle regulation by Nde1 controls cerebral cortical size
    Yuanyi Feng
    Department of Neurology, Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Neuron 44:279-93. 2004
    ..In vitro analysis demonstrated that Nde1 is essential for centrosome duplication and mitotic spindle assembly. Our data show that mitotic spindle function and orientation are essential for normal development of mammalian cerebral cortex...
  54. ncbi gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis
    Yonghua Pan
    Department of Molecular Biology and Pharmacology, Division of Dermatology, Washington University School of Medicine, Box 8103, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Dev Cell 7:731-43. 2004
    ....
  55. ncbi Epithelial hedgehog signals pattern the intestinal crypt-villus axis
    Blair B Madison
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109 0616, USA
    Development 132:279-89. 2005
    ..Thus, through a combined Hh signal to underlying ISEMFs, the epithelium patterns the crypt-villus axis, ensuring the proper size and location of the emerging precrypt compartment...
  56. ncbi Role for Runx1 in the proliferation and neuronal differentiation of selected progenitor cells in the mammalian nervous system
    Francesca M Theriault
    Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, H3A 2B4 Canada
    J Neurosci 25:2050-61. 2005
    ..Together, these findings suggest a previously unrecognized role for Runx1 in coordinating the proliferation and neuronal differentiation of selected populations of neural progenitors...
  57. ncbi Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung
    Weiguo Shu
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Biol 283:226-39. 2005
    ..Thus, Wnt/beta-catenin signaling is a critical upstream regulator of proximal-distal patterning in the lung, in part, through regulation of N-myc, BMP4, and FGF signaling...
  58. ncbi Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells
    Nicolas Matt
    Institut de Génétique et de Biologie Moléculaire et Cellulaire IGBMC Collège de France, BP10142, 67404 Illkirch Cedex, CU de Strasbourg, France
    Development 132:4789-800. 2005
    ..We additionally show that RALDH1 and RALDH3 are the only enzymes that are required for RA synthesis in the eye region from E10.5 to E13.5, and that patterning of the dorsoventral axis of the retina does not require RA...
  59. ncbi Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs
    Rui Yi
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10021, USA
    Nat Genet 38:356-62. 2006
    ..Here we characterize miRNAs in skin, the existence of which was hitherto unappreciated, and demonstrate their differential expression and importance in the morphogenesis of epithelial tissues within this vital organ...
  60. pmc alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway
    Wen Hui Lien
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Science 311:1609-12. 2006
    ..We propose that alphaE-catenin connects cell-density-dependent adherens junctions with the developmental hedgehog pathway and that this connection may provide a negative feedback loop controlling the size of developing cerebral cortex...
  61. ncbi Inactivation of aPKClambda results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex
    Fumiyasu Imai
    Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, 3 9 Fuku ura, Kanazawa Ku, Yokohama 236 0004, Japan
    Development 133:1735-44. 2006
    ..Therefore, we concluded that, at least in the later stages of neurogenesis, regulation of cell cycle exit is independent of adherens junctions...
  62. ncbi Math5 is required for both early retinal neuron differentiation and cell cycle progression
    Tien T Le
    Division of Developmental Biology, Children s Hospital Research Foundation, Departments of Pediatrics and Ophthalmology University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 7007, USA
    Dev Biol 295:764-78. 2006
    ..Thus, Math5 orchestrates neurogenesis in multiple ways, regulating both intrinsic and extrinsic processes...
  63. ncbi FGF signalling generates ventral telencephalic cells independently of SHH
    Grigoriy Gutin
    Departments of Neuroscience and Molecular Genetics, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA
    Development 133:2937-46. 2006
    ..Moreover, the Fgfr1;Fgfr2 phenotype, unlike the Shh phenotype, is not rescued by loss of Gli3, further indicating that FGFs act downstream of Shh and Gli3 to generate ventral telencephalic cell types...
  64. ncbi Hes1 and Hes5 control the progenitor pool, intermediate lobe specification, and posterior lobe formation in the pituitary development
    Aya Kita
    Department of Neurosurgery, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Mol Endocrinol 21:1458-66. 2007
    ..Thus, Hes genes control not only maintenance of progenitor cells but also intermediate vs. anterior lobe specification during the adenohypophysis development. Hes genes are also essential for the formation of the neurohypophysis...
  65. ncbi Foxp2 and Foxp1 cooperatively regulate lung and esophagus development
    Weiguo Shu
    Cardiovascular Institute, University of Pennsylvania, 956 BRB II III, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Development 134:1991-2000. 2007
    ....
  66. pmc Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development
    Yves Benninger
    Institute of Cell Biology, Department of Biology, Eidgenossische Technische Hochschule Zurich, CH 8093 Zurich, Switzerland
    J Cell Biol 177:1051-61. 2007
    ..Our results indicate that although cdc42 is required for normal Schwann cell proliferation, rac1 regulates Schwann cell process extension and stabilization, allowing efficient radial sorting of axon bundles...
  67. ncbi Physiologically distinct temporal cohorts of cortical interneurons arise from telencephalic Olig2-expressing precursors
    Goichi Miyoshi
    Neuroscience Program and Department of Cell Biology, Smilow Research Center, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 27:7786-98. 2007
    ..We observe that the physiological subtypes of cortical interneurons are, to a large degree, unique to their time point of generation...
  68. ncbi Cux-2 controls the proliferation of neuronal intermediate precursors of the cortical subventricular zone
    Beatriz Cubelos
    Centro Nacional de Biotecnologia, CSIC, Darwin 3, Campus de Cantoblanco, Madrid 28049, Spain
    Cereb Cortex 18:1758-70. 2008
    ..Our results point to Cux-2 as a key element in the control of the proliferation rates of the SVZ precursors and the number of upper cortical neurons, without altering the number of deep cortical layers...
  69. pmc An obligatory role of mind bomb-1 in notch signaling of mammalian development
    Bon Kyoung Koo
    Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, South Korea
    PLoS ONE 2:e1221. 2007
    ..However, the respective roles of the mammalian E3 ubiquitin ligases, Neur1, Neur2, Mib1, and Mib2, in mammalian development are poorly understood...
  70. pmc Foxg1 haploinsufficiency reduces the population of cortical intermediate progenitor cells: effect of increased p21 expression
    Julie A Siegenthaler
    Department of Neuroscience and Physiology, State University of New York Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Cereb Cortex 18:1865-75. 2008
    ..Thus, the present data are consistent with the above hypotheses, particularly, that during corticogenesis, Foxg1-regulated activities enable the expansion of the IPC population likely through suppression of p21-dependent cell-cycle exit...
  71. ncbi Neuroepithelial progenitors undergo LGN-dependent planar divisions to maintain self-renewability during mammalian neurogenesis
    Daijiro Konno
    Laboratory for Cell Asymmetry, Center for Developmental Biology, RIKEN, and CREST, Japan Science and Technology Corporation, RIKEN, 2 2 3 Minatojima minamimachi, Chuou ku, Kobe 650 0047, Japan
    Nat Cell Biol 10:93-101. 2008
    ..Our results suggest that planar mitosis ensures the self-renewal of neuroepithelial progenitors by one daughter inheriting both apical and basal compartments during neurogenesis...
  72. pmc COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signaling
    Andrea Faedo
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, CA 94158, USA
    Cereb Cortex 18:2117-31. 2008
    ..We suggest that COUP-TFI controls these processes by repressing Mapk/Erk, Akt, and beta-catenin signaling...
  73. doi Sox9 and Sox10 influence survival and migration of oligodendrocyte precursors in the spinal cord by regulating PDGF receptor alpha expression
    Markus Finzsch
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, Fahrstrasse 17, D 91054 Erlangen, Germany
    Development 135:637-46. 2008
    ..We thus conclude that Sox9 and Sox10 are required in a functionally redundant manner in oligodendrocyte precursors for PDGF-dependent survival and migration...
  74. doi Transient expression of the conserved zinc finger gene INSM1 in progenitors and nascent neurons throughout embryonic and adult neurogenesis
    Anne Duggan
    Department of Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Comp Neurol 507:1497-520. 2008
    ..We propose that, in mice and humans, INSM1 is likewise expressed transiently during terminal neurogenic divisions, from late progenitors to nascent neurons, and particularly during symmetric neuronogenic divisions...
  75. pmc NFATc1 balances quiescence and proliferation of skin stem cells
    Valerie Horsley
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    Cell 132:299-310. 2008
    ..Our findings may explain why patients receiving cyclosporine A for immunosuppressive therapy display excessive hair growth, and unveil a functional role for calcium-NFATc1-CDK4 circuitry in governing stem cell quiescence...
  76. pmc Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure
    Jian Fu Chen
    Carolina Cardiovascular Biology Center, Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 105:2111-6. 2008
    ..Together, our studies demonstrate essential roles for Dicer in cardiac contraction and indicate that miRNAs play critical roles in normal cardiac function and under pathological conditions...
  77. pmc Modular patterning of structure and function of the striatum by retinoid receptor signaling
    Wen Lin Liao
    Institute of Neuroscience, Center of Neuroscience, Department of Life Sciences, National Yang Ming University, Taipei, Taiwan 112, Republic of China
    Proc Natl Acad Sci U S A 105:6765-70. 2008
    ..RARbeta signaling thus plays a crucial role in setting up striatal compartments that may engage in neural circuits of psychomotor control...
  78. doi Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion
    Sven Falk
    Institute of Cell Biology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Cell Stem Cell 2:472-83. 2008
    ..Thus, TGF-beta signaling controls the size of a specific brain area, the dorsal midbrain, by antagonizing canonical Wnt signaling and negatively regulating self-renewal of neuroepithelial stem cells...
  79. doi Dynamic regulation of retinoic acid-binding proteins in developing, adult and neoplastic skin reveals roles for beta-catenin and Notch signalling
    Charlotte A Collins
    Wellcome Trust Centre for Stem Cell Research, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Dev Biol 324:55-67. 2008
    ..Our findings demonstrate that there is dynamic regulation of RA signalling in different regions of the skin and provide evidence for interactions between the RA, beta-catenin and Notch pathways...
  80. pmc Apc inhibition of Wnt signaling regulates supernumerary tooth formation during embryogenesis and throughout adulthood
    Xiu Ping Wang
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Development 136:1939-49. 2009
    ..In addition, we identify Fgf8, a known tooth initiation marker, as a direct target of Wnt/beta-catenin signaling. These studies identify key mechanistic features responsible for supernumerary tooth formation...
  81. pmc Regulation of TGF-beta signalling by Fbxo11, the gene mutated in the Jeff otitis media mouse mutant
    Hilda Tateossian
    MRC Mammalian Genetics Unit, Harwell, OX11 0RD, UK
    Pathogenetics 2:5. 2009
    ..TGF-beta signalling is involved in a number of epithelial developmental processes and we have investigated the impact of the Jeff mutation on the expression of this pathway...
  82. pmc Fgf10 regulates transition period of cortical stem cell differentiation to radial glia controlling generation of neurons and basal progenitors
    Setsuko Sahara
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Neuron 63:48-62. 2009
    ....
  83. pmc A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging
    Matilde Murga
    Genomic Instability Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Nat Genet 41:891-8. 2009
    ....
  84. pmc The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain
    Xudong Zhao
    Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA
    Dev Cell 17:210-21. 2009
    ..Our results indicate that Huwe1 balances proliferation and neurogenesis in the developing brain and that this pathway is subverted in malignant brain tumors...
  85. pmc Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality
    Sonia Klinger
    Institut de Recherche en Immunologie et Cancérologie and Departments of Pharmacology and Molecular Biology, Universite de Montreal, Montreal, Quebec, Canada
    Proc Natl Acad Sci U S A 106:16710-5. 2009
    ..Our findings reveal a critical role for Erk3 in the establishment of fetal growth potential and pulmonary function in the mouse...
  86. pmc LIM homeodomain transcription factor-dependent specification of bipotential MGE progenitors into cholinergic and GABAergic striatal interneurons
    Apostolia Fragkouli
    MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Development 136:3841-51. 2009
    ..These studies suggest that a LIM homeodomain transcriptional code confers cell-fate specification and neurotransmitter identity in neuronal subpopulations of the ventral forebrain...
  87. pmc FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis
    Ji Hye Paik
    Department of Medical Oncology, Belfer Institute for Applied Cancer Science, Harvard Medical School, Boston, MA 02115, USA
    Cell Stem Cell 5:540-53. 2009
    ..Thus, the FoxO family coordinately regulates diverse genes and pathways to govern key aspects of NSC homeostasis in the mammalian brain...
  88. pmc Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development
    Josselin Soyer
    Institute of Genetics and Molecular and Cell Biology IGBMC, INSERM U 964, CNRS UMR7104, University of Strasbourg, Illkirch, France
    Development 137:203-12. 2010
    ..By contrast, beta cells, whose number is only slightly reduced, were no longer clustered in a compact islet. These data unveil Rfx6 as a novel regulator of islet cell development...
  89. pmc Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression
    Hai Song
    Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:1431-6. 2010
    ....
  90. pmc Progenitor cell expansion and organ size of mouse adrenal is regulated by sonic hedgehog
    Chen Che Jeff Huang
    Department of Veterinary Biosciences, University of Illinois, 2001 South Lincoln Avenue, Urbana, Illinois 61802, USA
    Endocrinology 151:1119-28. 2010
    ..Our results not only provide the genetic evidence to support that the adrenal capsule contributes to the growth of adrenocortex in both fetal and adult life but also identify a novel role of Shh in this process...
  91. pmc The tumor suppressor merlin is required for cell cycle exit, terminal differentiation, and cell polarity in the developing murine lens
    Luke A Wiley
    Departments of Ophthalmology and Visual Sciences, Washington University, St Louis, MO, USA
    Invest Ophthalmol Vis Sci 51:3611-8. 2010
    ..The lens provides an assay system to identify pathways critical for fiber cell differentiation and to test therapies for the tumors that occur in patients with NF2...
  92. pmc Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival
    Georg Mellitzer
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, INSERM U964, CNRS UMR 7104, Universite de Strasbourg, Illkirch, France
    J Clin Invest 120:1708-21. 2010
    ..Our data help unravel the role of enteroendocrine cells and hormones in lipid absorption and maintenance of the intestinal epithelium...
  93. pmc CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells
    Karen B O'Brien
    Harvard Stem Cell Institute and Center for Life Sciences, Harvard Medical School, Boston, MA 02115, USA
    Development 137:2147-56. 2010
    ..These results demonstrate for the first time that CARM1 inhibits pulmonary cell proliferation and is required for proper differentiation of alveolar cells...
  94. pmc Interactions of Wnt/beta-catenin signaling and sonic hedgehog regulate the neurogenesis of ventral midbrain dopamine neurons
    Mianzhi Tang
    Department of Pathology, University of California, San Francisco and Pathology Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Neurosci 30:9280-91. 2010
    ..Persistent activation of beta-catenin in early progenitors perturbs their cell cycle progression and antagonizes Shh expression, whereas activation of beta-catenin in midline progenitors promotes the generation of dopamine neurons...
  95. doi Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun
    Joerg D Hoeck
    Mammalian Genetics Laboratory, Cancer Research UK London Research Institute, London, UK
    Nat Neurosci 13:1365-72. 2010
    ..Thus Fbw7 controls neurogenesis by antagonizing Notch and c-Jun N-terminal kinase (JNK)/c-Jun signaling...
  96. pmc Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation
    Kei Ichi Katayama
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 108:7607-12. 2011
    ..These results demonstrate a critical role of RhoA in the maintenance of apical adherens junctions and the regulation of neural progenitor proliferation in the developing mammalian brain...
  97. doi MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1-Cdc25 pathway
    Ralph Gruber
    Leibniz Institute for Age Research Fritz Lipmann Institute, Beurtenbergstrasse 11, 07745 Jena, Germany
    Nat Cell Biol 13:1325-34. 2011
    ..Thus, MCPH1, through its function in the Chk1-Cdc25-Cdk1 pathway to couple the centrosome cycle with mitosis, is required for precise mitotic spindle orientation and thereby regulates the progenitor division mode to maintain brain size...
  98. pmc Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice
    Katrin Arnold
    Howard Hughes Medical Institute and Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Medical School, Cambridge, MA 02138, USA
    Cell Stem Cell 9:317-29. 2011
    ..Thus, our results identify Sox2 expression in numerous adult endodermal and ectodermal stem cell compartments, which are critical for normal tissue regeneration and survival...
  99. doi Foxg1 has an essential role in postnatal development of the dentate gyrus
    Chuanxi Tian
    Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Institute of Life Science, Southeast University, Nanjing 210009, China
    J Neurosci 32:2931-49. 2012
    ..Last, prenatal deletion of Foxg1 suggests that it is rarely involved in the migration of primordial granule cells. In summary, we report that Foxg1 is critical for DG formation, especially during early postnatal stage...
  100. pmc Snf2l regulates Foxg1-dependent progenitor cell expansion in the developing brain
    Darren J Yip
    Regenerative Medicine Program, Ottawa Hospital Research Institute, and Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada
    Dev Cell 22:871-8. 2012
    ..We demonstrate that Snf2l binds to the Foxg1 locus at midneurogenesis and that the phenotype is rescued by reducing Foxg1 dosage, thus revealing that Snf2l and Foxg1 function antagonistically to regulate brain size...
  101. pmc Fate-restricted neural progenitors in the mammalian cerebral cortex
    Santos J Franco
    Dorris Neuroscience Center and Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 337:746-9. 2012
    ..Because upper cortical layers were expanded during primate evolution, amplification of this RGC pool may have facilitated human brain evolution...

Research Grants13

  1. RECIPROCAL INTERACT - JVC T-ANTIGEN AND HOST REG FACTORS
    Kamel Khalili; Fiscal Year: 2003
    ..abstract_text> ..
  2. Viral Model for Neuroimmune Interaction in Brain
    Kamel Khalili; Fiscal Year: 2005
    ..abstract_text> ..
  3. Expression profiling of human islets
    KLAUS KAESTNER; Fiscal Year: 2006
    ....
  4. The role of HNF4 in gastrointestinal development
    Michele Battle; Fiscal Year: 2006
    ..By understanding how this transcription factor functions in the gut, greater insight into the fundamental molecular processes underlying gut development wilt be gained. ..
  5. VIRAL MODEL FOR TUMOR PATHOGENESIS IN BRAIN
    Kamel Khalili; Fiscal Year: 2007
    ..abstract_text> ..
  6. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
    ....
  7. 6th International Symposium of Neurovirology
    Kamel Khalili; Fiscal Year: 2004
    ..It is anticipated that approximately 350 individuals attending the 6th Symposium. ..
  8. Human Neurotropic JC Virus and CNS Diseases
    Kamel Khalili; Fiscal Year: 2006
    ..abstract_text> ..
  9. CONTROL OF MATRIX PROTEOLYSIS BY INTEGRIN A3B1 IN SKIN
    C DiPersio; Fiscal Year: 2005
    ....
  10. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  11. Fetal Lung Development:Role of Wnt5a Signaling
    Changgong Li; Fiscal Year: 2008
    ..This information will be of utility in understanding the molecular mechanisms of congenital and induced lung disease. ..
  12. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2007
    ..The new resources generated through this project will be made available to the NIDDK-funded biotechnology centers and the diabetes research community at large. ..
  13. Liver Biology, Development and Disease
    KLAUS KAESTNER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..