Jun

Summary

Gene Symbol: Jun
Description: jun proto-oncogene
Alias: AP-1, Junc, c-jun, transcription factor AP-1, AH119, AP1, Jun oncogene, V-jun avian sarcoma virus 17 oncogene homolog, activator protein 1, immediate early, jun A, proto-oncogene c-jun
Species: mouse

Top Publications

  1. ncbi Induction of proto-oncogene JUN/AP-1 by serum and TPA
    W W Lamph
    Molecular Biology and Virology Laboratory, Salk Institute, San Diego, California 92138
    Nature 334:629-31. 1988
  2. pmc c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation
    K Sabapathy
    Research Institute of Molecular Pathology, Vienna A 1030, Austria
    J Exp Med 193:317-28. 2001
  3. ncbi JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms
    Jean Pierre David
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    J Cell Sci 115:4317-25. 2002
  4. ncbi Insulin-mediated activation of activator protein-1 through the mitogen-activated protein kinase pathway stimulates collagenase-1 gene transcription in the MES 13 mesangial cell line
    J E Ayala
    Department of Molecular Physiology and Biophysics, 761 PRB MRB II, Vanderbilt University Medical School, Nashville, Tennessee 37232 0615, USA
    J Mol Endocrinol 33:263-80. 2004
  5. ncbi Nuclear factor kappaB and activating protein 1 are involved in differentiation-related resistance to oxidative stress in skeletal muscle cells
    M Valeria Catani
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    Free Radic Biol Med 37:1024-36. 2004
  6. ncbi The LIM protein, Limd1, regulates AP-1 activation through an interaction with Traf6 to influence osteoclast development
    Yunfeng Feng
    Department of Medicine, Washington University, St Louis, Missouri 63110, USA
    J Biol Chem 282:39-48. 2007
  7. pmc TNF-alpha induces TGF-beta1 expression in lung fibroblasts at the transcriptional level via AP-1 activation
    Deborah E Sullivan
    Department of Microbiology and Immunology, Biomedical Sciences Graduate Program, Tulane University School of Medicine, New Orleans, LA, USA
    J Cell Mol Med 13:1866-76. 2009
  8. ncbi Essential role of Jun family transcription factors in PU.1 knockdown-induced leukemic stem cells
    Ulrich Steidl
    Harvard Institutes of Medicine, Harvard Medical School and Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA
    Nat Genet 38:1269-77. 2006
  9. doi Jun and JunD-dependent functions in cell proliferation and stress response
    A Meixner
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria
    Cell Death Differ 17:1409-19. 2010
  10. pmc AP1 factor inactivation in the suprabasal epidermis causes increased epidermal hyperproliferation and hyperkeratosis but reduced carcinogen-dependent tumor formation
    E A Rorke
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Oncogene 29:5873-82. 2010

Detail Information

Publications170 found, 100 shown here

  1. ncbi Induction of proto-oncogene JUN/AP-1 by serum and TPA
    W W Lamph
    Molecular Biology and Virology Laboratory, Salk Institute, San Diego, California 92138
    Nature 334:629-31. 1988
    ..Prominent among these so-called 'immediate early' or 'competence' genes are the nuclear oncogenes fos and myc...
  2. pmc c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation
    K Sabapathy
    Research Institute of Molecular Pathology, Vienna A 1030, Austria
    J Exp Med 193:317-28. 2001
    Apoptotic and mitogenic stimuli activate c-Jun NH2-terminal kinases (JNKs) in T cells...
  3. ncbi JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms
    Jean Pierre David
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    J Cell Sci 115:4317-25. 2002
    Phosphorylation of the N-terminal domain of Jun by the Jun kinases (JNKs) modulates the transcriptional activity of AP-1, a dimeric transcription factor typically composed of c-Jun and c-Fos, the latter being essential for osteoclast ..
  4. ncbi Insulin-mediated activation of activator protein-1 through the mitogen-activated protein kinase pathway stimulates collagenase-1 gene transcription in the MES 13 mesangial cell line
    J E Ayala
    Department of Molecular Physiology and Biophysics, 761 PRB MRB II, Vanderbilt University Medical School, Nashville, Tennessee 37232 0615, USA
    J Mol Endocrinol 33:263-80. 2004
    ..In MES 13 cells, the AP-1 motif is bound by Fra-1, Fra-2, Jun B and Jun D...
  5. ncbi Nuclear factor kappaB and activating protein 1 are involved in differentiation-related resistance to oxidative stress in skeletal muscle cells
    M Valeria Catani
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    Free Radic Biol Med 37:1024-36. 2004
    ..In conclusion, the two cell lines, although similar in terms of growth and differentiation, displayed significant heterogeneity in terms of redox homeostasis...
  6. ncbi The LIM protein, Limd1, regulates AP-1 activation through an interaction with Traf6 to influence osteoclast development
    Yunfeng Feng
    Department of Medicine, Washington University, St Louis, Missouri 63110, USA
    J Biol Chem 282:39-48. 2007
    ..These results implicate Limd1 as a potentially important regulator of osteoclast development under conditions of stress...
  7. pmc TNF-alpha induces TGF-beta1 expression in lung fibroblasts at the transcriptional level via AP-1 activation
    Deborah E Sullivan
    Department of Microbiology and Immunology, Biomedical Sciences Graduate Program, Tulane University School of Medicine, New Orleans, LA, USA
    J Cell Mol Med 13:1866-76. 2009
    ..TNF-alpha induced increased levels of c-Jun and C-Fos in the nucleus accompanied by phosphorylation of c-Jun...
  8. ncbi Essential role of Jun family transcription factors in PU.1 knockdown-induced leukemic stem cells
    Ulrich Steidl
    Harvard Institutes of Medicine, Harvard Medical School and Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA
    Nat Genet 38:1269-77. 2006
    ..1-knockdown HSCs') to identify transcriptional changes preceding malignant transformation. Transcription factors c-Jun and JunB were among the top-downregulated targets...
  9. doi Jun and JunD-dependent functions in cell proliferation and stress response
    A Meixner
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria
    Cell Death Differ 17:1409-19. 2010
    b>Jun is essential for fetal development, as fetuses lacking Jun die at mid-gestation with multiple cellular defects in liver and heart...
  10. pmc AP1 factor inactivation in the suprabasal epidermis causes increased epidermal hyperproliferation and hyperkeratosis but reduced carcinogen-dependent tumor formation
    E A Rorke
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Oncogene 29:5873-82. 2010
    Activator protein one (AP1) (jun/fos) factors comprise a family of transcriptional regulators (c-jun, junB, junD, c-fos, FosB, Fra-1 and Fra-2) that are key controllers of epidermal keratinocyte survival and differentiation, and are ..
  11. ncbi H2O2-dependent activation of GCLC-ARE4 reporter occurs by mitogen-activated protein kinase pathways without oxidation of cellular glutathione or thioredoxin-1
    Young Mi Go
    Department of Medicine, Division of Cardiology, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 279:5837-45. 2004
    ..H2O2 signaling to ARE4 was mediated by activation of both the c-Jun N-terminal kinase and ERK1/2 pathways modulated by Ras...
  12. doi Basic fibroblast growth factor-induced neuronal differentiation of mouse bone marrow stromal cells requires FGFR-1, MAPK/ERK, and transcription factor AP-1
    Haijie Yang
    Research Laboratories, National Neuroscience Institute, Singapore 308433
    J Biol Chem 283:5287-95. 2008
    ..the immediate-early transcription factors AP-1 and NF-kappaB and have found that phospholipase C-gamma-dependent c-Jun and ERK-dependent c-fos, but not the NF-kappaB, are strongly activated by bFGF, which in turn regulates the ..
  13. doi Inhibition of myoblast differentiation by tumor necrosis factor alpha is mediated by c-Jun N-terminal kinase 1 and leukemia inhibitory factor
    Joel Alter
    Department of Biochemistry, Technion Israel Institute of Technology, Haifa 31096, Israel
    J Biol Chem 283:23224-34. 2008
    ..In the present study, the role of c-Jun N-terminal kinase (JNK), a mediator of TNFalpha, was investigated in differentiating myoblast cell lines...
  14. pmc Inhibition of AP-1 transcriptional activity blocks the migration, invasion, and experimental metastasis of murine osteosarcoma
    Virna D Leaner
    Cell and Cancer Biology Department, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Pathol 174:265-75. 2009
    ..This study shows that differences in metastatic activity can be due to AP-1 activation. The inhibition of AP-1 activity may serve as a therapeutic tool in the management of osteosarcoma...
  15. pmc Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor kappa B and activator protein-1: possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia
    Philipp Wiesner
    Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0682, USA
    Circ Res 107:56-65. 2010
    ..In addition, low-level but persistent metabolic endotoxemia is often found in diabetic and obese subjects and is induced in mice fed a high-fat diet...
  16. pmc Induction of protooncogene c-jun by serum growth factors
    K Ryder
    Howard Hughes Medical Institute Laboratory, Baltimore, MD
    Proc Natl Acad Sci U S A 85:8464-7. 1988
    ..We have previously reported that one of the genes that is rapidly induced in mouse 3T3 cells by serum growth factors (jun-B) encodes a protein related to the onco-protein v-jun...
  17. doi FoxP3 maintains Treg unresponsiveness by selectively inhibiting the promoter DNA-binding activity of AP-1
    Sang Myeong Lee
    Department of Otolaryngology Head and Neck Surgery, University of Missouri Columbia School of Medicine 65212, USA
    Blood 111:3599-606. 2008
    ..binding is not the result of the decreased nuclear translocation of AP-1 family transcription factors, including c-Jun, JunB, and c-Fos...
  18. pmc SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages
    Ran Zhang
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China
    J Biol Chem 285:7097-110. 2010
    ..Here we demonstrate that SIRT1 directly interacts with the basic leucine zipper domains of c-Fos and c-Jun, the major components of AP-1, by which SIRT1 suppressed the transcriptional activity of AP-1...
  19. pmc A novel mouse c-fos intronic promoter that responds to CREB and AP-1 is developmentally regulated in vivo
    Vincent Coulon
    Institut de Genetique Moleculaire de Montpellier, Centre National de la Recherche Scientifique, Universite Montpellier 2, Universite Montpellier 1, Montpellier, France
    PLoS ONE 5:e11235. 2010
    ..Innumerable studies have focused on the canonical promoter, located upstream from the transcriptional start site. However, several regulatory sequences have been found in the first intron...
  20. pmc Ethanol-induced HO-1 and NQO1 are differentially regulated by HIF-1alpha and Nrf2 to attenuate inflammatory cytokine expression
    Samantha M Yeligar
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 285:35359-73. 2010
    ..Furthermore, livers of ethanol-fed c-Jun(fl/fl) mice showed reduced levels of mRNA for HO-1 but not of NQO1 compared with ethanol-fed control rats, ..
  21. doi Macrophage-derived BAFF induces AID expression through the p38MAPK/CREB and JNK/AP-1 pathways
    Hyun A Kim
    Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 200 701, Republic of Korea
    J Leukoc Biol 89:393-8. 2011
    ..Our findings suggest that macrophage-derived BAFF stimulates B cells to express AID through BCMA and at least two different pathways, including the p38MAPK/CREB and the JNK/AP-1 pathways...
  22. pmc c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation
    M Palmada
    Department of Biology, University of California, San Diego, 92138, USA
    J Cell Biol 158:453-61. 2002
    ..transcription-dependent apoptotic response, which is suggested to require activation of the transcription factor c-Jun. Similarly, apoptosis can also be induced by selective activation of the p75 neurotrophin receptor...
  23. ncbi IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
    Shin Maeda
    Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego, 9500 Gilman Drive MC 0723, La Jolla, California 92093, USA
    Cell 121:977-90. 2005
    ..IKKbeta, therefore, orchestrates inflammatory crosstalk between hepatocytes and hematopoietic-derived cells that promotes chemical hepatocarcinogenesis...
  24. pmc The FGF-BMP signaling axis regulates outflow tract valve primordium formation by promoting cushion neural crest cell differentiation
    Jue Zhang
    Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A and M Health Science Center, Houston, TX 77030 3303, USA
    Circ Res 107:1209-19. 2010
    ..Disruption of the fibroblast growth factor (FGF) signaling axis impairs morphogenesis of the outflow tract (OFT). Yet, whether FGF signaling regulates OFT valve formation is unknown...
  25. ncbi Embryonic stem (ES) cells lacking functional c-jun: consequences for growth and differentiation, AP-1 activity and tumorigenicity
    F Hilberg
    Research Institute of Molecular Pathology IMP, Vienna, Austria
    Oncogene 7:2371-80. 1992
    The proto-oncogene c-jun encodes the major component of the transcription factor AP-1 and is thought to have important functions in cell proliferation and differentiation as well as in the cellular response to a variety of external ..
  26. ncbi Cloning of the human glycine transporter type 1: molecular and pharmacological characterization of novel isoform variants and chromosomal localization of the gene in the human and mouse genomes
    K M Kim
    Howard Hughes Medical Institute Research Laboratories, Department of Cell Biology and Medicine, Duke University Medical Center, Durham, North Carolina 27710
    Mol Pharmacol 45:608-17. 1994
    ..These variants point to regions of the glycine transporter that might be important in the processing or transport function of this protein...
  27. pmc The Wnt antagonist Dickkopf-1 is regulated by Bmp signaling and c-Jun and modulates programmed cell death
    Lars Grotewold
    Entwicklungs und Molekularbiologie der Tiere, Heinrich Heine Universitat, D 40225 Dusseldorf, Germany
    EMBO J 21:966-75. 2002
    ..We further show that normal expression of Dkk-1 is dependent on the Ap-1 family member c-Jun and that overexpression of Dkk-1 enhances Bmp-triggered apoptosis in the vertebrate limb...
  28. pmc The response of c-jun/AP-1 to chronic hypoxia is hypoxia-inducible factor 1 alpha dependent
    Keith R Laderoute
    Pharmaceutical Discovery Division, SRI International, Menlo Park, California 94025, USA
    Mol Cell Biol 22:2515-23. 2002
    ..Prolonged or chronic hypoxia stimulates expression of the stress-inducible transcription factor gene c-jun and transient activation of protein kinase and phosphatase activities that regulate c-Jun/AP-1 activity...
  29. ncbi AP-1 transrepressing retinoic acid does not deplete coactivators or AP-1 monomers but may target specific Jun or Fos containing dimers
    Kazumi Suzukawa
    Gene Regulation Section, Basic Research Laboratory, National Cancer Institute at Frederick, Frederick, Maryland 21702 1201, USA
    Oncogene 21:2181-90. 2002
    ..induced AP-1 activation nor did a GST pull down experiment implicate direct binding, thus rendering unlikely both a Jun/Fos-RA-RAR direct interaction and a Jun/Fos sequestration mechanism...
  30. ncbi Simulated microgravity suppresses osteoblast phenotype, Runx2 levels and AP-1 transactivation
    C Ontiveros
    Department of Physiology, Michigan State University, 2201 Biomedical Physical Science Bldg, East Lansing 48824, USA
    J Cell Biochem 88:427-37. 2003
    ..Taken together, our results indicate that simulated microgravity may suppress osteoblast differentiation through decreased runx2 and AP-1 activities...
  31. ncbi Erk pathway and activator protein 1 play crucial roles in FGF2-stimulated premature cranial suture closure
    Hyun Jung Kim
    Department of Biochemistry, School of Dentistry, Kyungpook National University, Daegu, Korea
    Dev Dyn 227:335-46. 2003
    ..FGF2 treatment also induced fos and jun mRNAs and later increased the nuclear levels of activator protein 1 (AP1)...
  32. ncbi The gonadotropin releasing hormone (GnRH) receptor activating sequence (GRAS) is a composite regulatory element that interacts with multiple classes of transcription factors including Smads, AP-1 and a forkhead DNA binding protein
    Buffy S Ellsworth
    Animal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    Mol Cell Endocrinol 206:93-111. 2003
    ..We suggest that GRAS is a composite regulatory element whose functional activity is dependent on the organization of a multi-protein complex consisting of Smads, AP-1 and a member of the forkhead family of DNA binding proteins...
  33. ncbi The interaction between GATA proteins and activator protein-1 promotes the transcription of IL-13 in mast cells
    Akio Masuda
    Division of Host Defense, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Immunol 173:5564-73. 2004
    ..The results of the present study have shown that direct interaction between AP-1 and GATA proteins plays an important role in IL-13 transcription in mast cells...
  34. ncbi Increased keratinocyte proliferation by JUN-dependent expression of PTN and SDF-1 in fibroblasts
    Lore Florin
    Division of Signal Transduction and Growth Control, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Cell Sci 118:1981-9. 2005
    ..The AP-1 transcription factor subunit JUN plays a crucial role in this mesenchymal-epithelial interplay by regulating the expression of two critical ..
  35. ncbi A role for c-fos/activator protein 1 in B lymphocyte terminal differentiation
    Yusuke Ohkubo
    Department of Developmental Genetics H2, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Immunol 174:7703-10. 2005
    ..Thus, although c-Fos is not essential for Blimp-1 expression, c-Fos/AP-1 positively regulates Blimp-1 expression and terminal differentiation of activated B cells...
  36. ncbi Treatment of experimental asthma by decoy-mediated local inhibition of activator protein-1
    Christophe Desmet
    Laboratoire de Physiologie, Faculte de Medecine Veterinaire, Centre de Thérapie Cellulaire et Moléculaire, Universite de Liege, Belgium
    Am J Respir Crit Care Med 172:671-8. 2005
    ....
  37. ncbi Increased expression of interleukin-6 by vasoactive intestinal peptide is associated with regulation of CREB, AP-1 and C/EBP, but not NF-kappaB, in mouse calvarial osteoblasts
    Emma Persson
    Department of Oral Cell Biology, Umea University, SE 901 87 Umea, Sweden
    Bone 37:513-29. 2005
    ..The mRNA expressions of C/EBPbeta, C/EBPdelta, C/EBPgamma, c-Jun, JunB, c-Fos, Fra-1 and IkappaBalpha and protein level of IkappaBalpha were all unaffected by VIP...
  38. ncbi Polyinosinic acid induces TNF and NO production as well as NF-kappaB and AP-1 transcriptional activation in the monocytemacrophage cell line RAW 264.7
    V M Campa
    Instituto Universitario de Oncología del Principado de Asturias and Departamento de Bioquímica y Biología Molecular, Universidad de Oviedo, 33071 Oviedo, Spain
    Inflamm Res 54:328-37. 2005
    ..This study evaluates the poly inosinic acid (poly I)-induced activation in the murine monocytemacrophage cell line RAW 264.7, which led to an inflammatory phenotype...
  39. ncbi Role of AP-1 in ethanol-induced N-methyl-D-aspartate receptor 2B subunit gene up-regulation in mouse cortical neurons
    Mei Qiang
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Neurochem 95:1332-41. 2005
    b>Activator protein 1 (AP-1) has been reported to regulate the gene expression in a wide variety of cellular processes in response to stimuli...
  40. ncbi A role for Ets1, synergizing with AP-1 and GATA-3 in the regulation of IL-5 transcription in mouse Th2 lymphocytes
    Jun Wang
    Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Mills Road, Acton, ACT 0200 Australia
    Int Immunol 18:313-23. 2006
    ..AP-1 (c-Fos/c-Jun) strongly induced IL-5 transcription and dominant negative AP-1 constructs confirmed that AP-1 plays an important ..
  41. pmc TBP is differentially regulated by c-Jun N-terminal kinase 1 (JNK1) and JNK2 through Elk-1, controlling c-Jun expression and cell proliferation
    Shuping Zhong
    Department of Biochemistry and Molecular Biology, University of Southern California, 2011 Zonal Ave, Los Angeles, CA 90033, USA
    Mol Cell Biol 27:54-64. 2007
    Emerging evidence supports the idea that the c-Jun N-terminal kinases (JNKs) possess overlapping but distinct functions...
  42. ncbi Hyperactive variants of p38alpha induce, whereas hyperactive variants of p38gamma suppress, activating protein 1-mediated transcription
    Nadav Askari
    Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    J Biol Chem 282:91-9. 2007
    ..Active mutants of p38alpha induced AP-1-driven reporter genes, as well as the c-jun and c-fos promoters. An active variant of p38gamma suppressed AP-1-mediated transcription...
  43. ncbi Induction of activator protein-1 and nuclear factor-kappaB as a prerequisite for disease development in susceptible SJL/J mice after theiler murine encephalomyelitis
    Ingo Gerhauser
    Department of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany
    J Neuropathol Exp Neurol 66:809-18. 2007
    ..The expression of activator protein-1 (c-fos and c-jun) and nuclear factor-kappaB (p50 and p65) genes, TME virus, tumor necrosis factor-alpha, and interferon-gamma was ..
  44. pmc Fast regulation of AP-1 activity through interaction of lamin A/C, ERK1/2, and c-Fos at the nuclear envelope
    José María González
    Laboratory of Vascular Biology, Department of Molecular and Cellular Pathology and Therapy, Instituto de Biomedicina de Valencia, Consejo Superior de Investigaciones Cientificas CSIC, Valencia, Spain
    J Cell Biol 183:653-66. 2008
    ..Thus, NE-bound ERK1/2 functions as a molecular switch for rapid mitogen-dependent AP-1 activation through phosphorylation-induced release of preexisting c-Fos from its inhibitory interaction with lamin A/C...
  45. doi Viperin is required for optimal Th2 responses and T-cell receptor-mediated activation of NF-kappaB and AP-1
    Lian Qun Qiu
    Laboratory of Gene Regulation and Inflammation, Singapore Immunology Network, Biomedical Sciences Institutes, Singapore
    Blood 113:3520-9. 2009
    ..Thus, viperin facilitates TCR-mediated GATA-3 activation and optimal Th2 cytokine production by modulating NF-kappaB and AP-1 activities...
  46. pmc Effect of ultraviolet B radiation on activator protein 1 constituent proteins and modulation by dietary energy restriction in SKH-1 mouse skin
    Brian D Hopper
    Interdepartmental Toxicology Program, Iowa State University, Ames, Iowa 50011 1123, USA
    Mol Carcinog 48:843-52. 2009
    The study examined the timing of modulation of activator protein 1(AP-1):DNA binding and production of AP-1 constituent proteins by ultraviolet B (UVB) radiation and effect of dietary energy restriction [DER, 40% calorie reduction from ..
  47. doi Nuclear localization of c-FLIP-L and its regulation of AP-1 activity
    Jing Zhang
    Jiangsu Center of Hepatobiliary Diseases and the State Key Laboratory of Pharmaceutical Biotechnology, Affiliated Gulou Hospital, School of Life Sciences, Nanjing University, Nanjing, China
    Int J Biochem Cell Biol 41:1678-84. 2009
    ..In sum, our findings describe a novel function of c-FLIP-L involved in AP-1 activation and cell proliferation...
  48. pmc Helicobacter pylori induces ERK-dependent formation of a phospho-c-Fos c-Jun activator protein-1 complex that causes apoptosis in macrophages
    Mohammad Asim
    Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 285:20343-57. 2010
    ..shift assay and immunoprecipitation revealed a previously unrecognized complex of phospho-c-Fos (pc-Fos) and c-Jun in the nucleus. Fluorescence resonance energy transfer demonstrated the interaction of pc-Fos and c-Jun...
  49. ncbi Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts
    R P Ryseck
    European Molecular Biology Laboratory, Heidelberg, FRG
    Nature 334:535-7. 1988
    ..the nucleotide sequence of a mouse cDNA clone coding for a 334 residue protein which shows 80% similarity with v-JUN and more than 98% similarity with the human c-JUN sequence...
  50. pmc A gene activated by growth factors is related to the oncogene v-jun
    K Ryder
    Howard Hughes Medical Institute Laboratory, Baltimore, MD
    Proc Natl Acad Sci U S A 85:1487-91. 1988
    ..Here we report that the nucleotide sequence of a cDNA (clone 465) derived from one of these immediate early genes (hereafter called jun-B) encodes a protein homologous to that encoded by the avian sarcoma virus 17 ..
  51. ncbi Tissue-specific expression of the fos-related transcription factor fra-2 during mouse development
    D Carrasco
    Department of Molecular Biology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543 4000
    Oncogene 10:1069-79. 1995
    ..of fra-2 during mouse embryonic development and compared it to the pattern of expression of other fos and jun family members...
  52. ncbi A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death
    J Ham
    Eisai London Research Laboratories, University College London, United Kingdom
    Neuron 14:927-39. 1995
    ..We have investigated the pattern of expression of the Jun and Fos family of transcription factors in dying sympathetic neurons using antibodies specific for each family ..
  53. pmc Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis
    S Estus
    Department of Molecular Biology, Washington University School of Medicine, St Louis, Missouri 63110
    J Cell Biol 127:1717-27. 1994
    ..A temporal cascade of induced genes included "immediate early genes," which were remarkable in that their induction occurred hours after the initial stimulus of NGF ..
  54. ncbi c-jun is essential for normal mouse development and hepatogenesis
    F Hilberg
    Research Institute of Molecular Pathology IMP, Vienna, Austria
    Nature 365:179-81. 1993
    The proto-oncogene c-jun is the cellular homologue of v-jun, the transforming oncogene of the avian sarcoma virus 17 (ref. 1)...
  55. ncbi Programmed cell death in the absence of c-Fos and c-Jun
    S Roffler-Tarlov
    Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA
    Development 122:1-9. 1996
    ..factor, AP-1, in the regulation of programmed cell death, and specifically implicate the genes c-fos and c-jun, as well as some other family members...
  56. pmc c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms
    R Wisdom
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    EMBO J 18:188-97. 1999
    c-Jun is a component of the transcription factor AP-1, which is activated by a wide variety of extracellular stimuli...
  57. pmc JunB is essential for mammalian placentation
    M Schorpp-Kistner
    Deutsches Krebsforschungszentrum Heidelberg, Abteilung für Signaltransduktion und Wachstumskontrolle, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    EMBO J 18:934-48. 1999
    Lack of JunB, an immediate early gene product and member of the AP-1 transcription factor family causes embryonic lethality between E8.5 and E10.0...
  58. ncbi Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation
    A Behrens
    Research Institute of Molecular Pathology, Vienna, Austria
    Nat Genet 21:326-9. 1999
    c-Jun is a major component of the heterodimeric transcription factor AP-1 and is essential for embryonic development, as fetuses lacking Jun die at mid-gestation with impaired hepatogenesis and primary Jun-/- fibroblasts have a severe ..
  59. ncbi The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development
    C Y Kuan
    Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Neuron 22:667-76. 1999
    The c-Jun NH2-terminal kinase (Jnk) family is implicated in apoptosis, but its function in brain development is unclear. Here, we address this issue using mutant mice lacking different members of the family (Jnk1, Jnk2, and Jnk3)...
  60. pmc Functions of c-Jun in liver and heart development
    R Eferl
    Department of Pathology, University of Graz, A 8036 Graz, Austria
    J Cell Biol 145:1049-61. 1999
    Mice lacking the AP-1 transcription factor c-Jun die around embryonic day E13.0 but little is known about the cell types affected as well as the cause of embryonic lethality. Here we show that a fraction of mutant E13...
  61. ncbi JunB can substitute for Jun in mouse development and cell proliferation
    Emmanuelle Passegue
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nat Genet 30:158-66. 2002
    The Jun and JunB components of the AP-1 transcription factor are known to have antagonistic functions...
  62. pmc Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver
    Axel Behrens
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    EMBO J 21:1782-90. 2002
    Mice lacking the AP-1 transcription factor c-jun die at mid-gestation showing heart defects and impaired hepatogenesis. To inactivate c-jun in hepatocytes, mice carrying a floxed c-jun allele were generated...
  63. ncbi A dominant negative c-jun specifically blocks okadaic acid-induced skin tumor promotion
    Eric J Thompson
    Department of Pharmacology and Toxicology, The University of Arizona, Tucson, AZ 85724, USA
    Cancer Res 62:3044-7. 2002
    ..One or more of the pathways affected by OA leads to increased signaling via the activator protein 1 (AP-1) transcription factor...
  64. pmc Promoter specificity and biological activity of tethered AP-1 dimers
    Latifa Bakiri
    Unité Expression Génétique et Maladies, CNRS URA 1644, Institut Pasteur, 75724 Paris Cedex 15, France
    Mol Cell Biol 22:4952-64. 2002
    b>Activator protein 1 (AP-1) is a group of dimeric transcription factors composed of Jun, Fos, and ATF family proteins...
  65. ncbi Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53
    Robert Eferl
    Research Institute of Molecular Pathology IMP, Dr Bohrgasse 7, A 1030, Vienna, Austria
    Cell 112:181-92. 2003
    The transcription factor c-Jun mediates several cellular processes, including proliferation and survival, and is upregulated in many carcinomas...
  66. ncbi c-Jun regulates eyelid closure and skin tumor development through EGFR signaling
    Rainer Zenz
    Research Institute of Molecular Pathology IMP, A 1030, Vienna, Austria
    Dev Cell 4:879-89. 2003
    To investigate the function of c-Jun during skin development and skin tumor formation, we conditionally inactivated c-jun in the epidermis...
  67. pmc A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure
    Lin Zhang
    Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
    EMBO J 22:4443-54. 2003
    ..fibers in wild-type mice, but compact cell contacts, lack of polymerized actin and a concomitant impairment in c-Jun N-terminal phosphorylation in MEKK1-deficient mice...
  68. ncbi Expression of dominant negative c-jun inhibits ultraviolet B-induced squamous cell carcinoma number and size in an SKH-1 hairless mouse model
    Simon J Cooper
    Department of Radiation Oncology, Arizona Cancer Center, College of Public Health, The University of Arizona, Tucson, AZ, USA
    Mol Cancer Res 1:848-54. 2003
    ..the hypothesis that AP-1 activation plays a role in the promotion of UVB-induced skin tumors, a dominant negative c-jun (TAM67) mutant transgene was expressed in the epidermis of SKH-1 hairless mice and bred with mice expressing an AP-..
  69. pmc Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death
    David B Parkinson
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London, WC1E 6BT UK
    J Cell Biol 164:385-94. 2004
    ..Significantly, a major function of Krox-20 is to suppress the c-Jun NH2-terminal protein kinase (JNK)-c-Jun pathway, activation of which is required for both proliferation and death...
  70. pmc DCX, a new mediator of the JNK pathway
    Amos Gdalyahu
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
    EMBO J 23:823-32. 2004
    ..Here we demonstrate that DCX is a substrate of JNK and interacts with both c-Jun N-terminal kinase (JNK) and JNK interacting protein (JIP)...
  71. ncbi The AP-1 transcription factor c-Jun is required for efficient axonal regeneration
    Gennadij Raivich
    Perinatal Brain Repair Group, Department of Obstetrics and Gynaecology, University College London, 86 96 Chenies Mews, London WC1E 6HX, United Kingdom
    Neuron 43:57-67. 2004
    ..c-Jun is a component of the heterodimeric AP-1 transcription factor, and c-Jun is highly expressed in response to ..
  72. pmc The c-Jun NH2-terminal kinase is essential for epidermal growth factor expression during epidermal morphogenesis
    Claire R Weston
    Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 101:14114-9. 2004
    The c-Jun NH(2)-terminal kinase (JNK) group of mitogen-activated protein kinases is activated in response to a wide array of cellular stresses and proinflammatory cytokines...
  73. pmc c-Jun-deficient cells undergo premature senescence as a result of spontaneous DNA damage accumulation
    Ann MacLaren
    Beatson Institute for Cancer Research, Bearsden, UK
    Mol Cell Biol 24:9006-18. 2004
    Mouse embryo fibroblasts deficient for the c-Jun proto-oncogene (c-Jun-/- MEF) undergo p53-dependent premature senescence in conventional culture...
  74. ncbi Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light
    Tamara Tanos
    Laboratorio de Fisiologia y Biologia Molecular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IFIBYNE CONICET, 1428 Buenos Aires, Argentina
    J Biol Chem 280:18842-52. 2005
    ..This phosphorylation is transduced into changes in its transcriptional ability as p38-activated c-Fos enhances AP1-driven gene expression...
  75. ncbi Differential inhibition of UVB-induced AP-1 and NF-kappaB transactivation by components of the jun bZIP domain
    Simon Cooper
    Arizona Cancer Center, Tucson, Arizona 85724, USA
    Mol Carcinog 43:108-16. 2005
    ..of both these ultraviolet light B (UVB)-induced transcription factors has been shown with the dominant-negative c-jun mutant, TAM67; however, its mechanism of action has not yet been determined...
  76. ncbi Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development
    Abdolrahman S Nateri
    Mammalian Genetics Laboratory, CR UK London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Nature 437:281-5. 2005
    The proto-oncoprotein c-Jun is a component of the AP-1 transcription factor, the activity of which is augmented in many tumour types...
  77. ncbi Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins
    Rainer Zenz
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nature 437:369-75. 2005
    ..We propose that the abrogation of JunB/activator protein 1 (AP-1) in keratinocytes triggers chemokine/cytokine expression, which recruits neutrophils and macrophages ..
  78. ncbi c-Jun promotes cellular survival by suppression of PTEN
    K Hettinger
    Laboratory of Molecular Carcinogenesis, Division of Cellular and Molecular Research, National Cancer Centre, 11, Hospital Drive, Singapore 169610, Singapore
    Cell Death Differ 14:218-29. 2007
    Activation of c-Jun, a component of the AP-1 family of transcription factors, leads to either promotion or prevention of apoptosis. However, the molecular determinants of c-Jun-mediated cell survival are still unclear...
  79. pmc c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity
    Ewa Stepniak
    Research Institute of Molecular Pathology IMP, A 1030 Vienna, Austria
    Genes Dev 20:2306-14. 2006
    The AP-1 transcription factor c-Jun is a key regulator of hepatocyte proliferation. Mice lacking c-Jun in the liver (c-jun (Deltali*)) display impaired liver regeneration after partial hepatectomy (PH)...
  80. ncbi The c-Jun N-terminal kinase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex
    Syu ichi Hirai
    Department of Molecular Biology, Graduate School of Medical Science, Yokohama City University, Yokohama 236 0004, Japan
    J Neurosci 26:11992-2002. 2006
    ..Dual leucine zipper kinase (DLK) induces activation of c-Jun N-terminal kinase (JNK), a molecule that regulates morphogenesis in various organisms...
  81. ncbi Cyclooxygenase-2 gene transcription in a macrophage model of inflammation
    Yeon Joo Kang
    Cell and Molecular Biology Program, Michigan State University, East Lansing, MI 48824, USA
    J Immunol 177:8111-22. 2006
    ..In support of this concept, we found, using inhibitors of Jun kinase and NF-kappaB p50 nuclear localization, that COX-2 gene transcription was completely dependent on phospho-c-..
  82. pmc Somatic excision demonstrates that c-Jun induces cellular migration and invasion through induction of stem cell factor
    Sanjay Katiyar
    Departments of Cancer Biology and Medical Oncology, The Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    Mol Cell Biol 27:1356-69. 2007
    Cancer cells arise through sequential acquisition of mutations in tumor suppressors and oncogenes. c-Jun, a critical component of the AP-1 complex, is frequently overexpressed in diverse tumor types and has been implicated in promoting ..
  83. doi c-Jun supports ribosomal RNA processing and nucleolar localization of RNA helicase DDX21
    Tim H Holmström
    Centre for Biotechnology, University of Turku and Abo Akademi University, 20520 Turku, Finland
    J Biol Chem 283:7046-53. 2008
    The molecular mechanisms by which the AP-1 transcription factor c-Jun exerts its biological functions are not clearly understood...
  84. pmc c-Jun is a negative regulator of myelination
    David B Parkinson
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, England, UK
    J Cell Biol 181:625-37. 2008
    ..We report that c-Jun is an important regulator of this plasticity...
  85. pmc Restriction to Fos family members of Trip6-dependent coactivation and glucocorticoid receptor-dependent trans-repression of activator protein-1
    Markus Diefenbacher
    Institut für Toxikologie und Genetik, Forschungszentrum Karlsruhe, Hermann von Helmholtz Platz 1, D 76344 Eggenstein Leopoldshafen, Germany
    Mol Endocrinol 22:1767-80. 2008
    ..activator protein (AP)-1 describes homodimeric and heterodimeric transcription factors composed of members of the Jun, Fos, and cAMP response element-binding protein (CREB)/activating transcription factor (ATF) families of proteins...
  86. pmc Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells
    Elena Ezhkova
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    Cell 136:1122-35. 2009
    ..the Ink4A-Ink4B locus and tempers the developmental rate of differentiation by preventing premature recruitment of AP1 transcriptional activator to the structural genes that are required for epidermal differentiation...
  87. pmc FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate
    Jie Huang
    Department of Ophthalmology and Visual Sciences, Washington University, St Louis, MO 63130, USA
    Development 136:1741-50. 2009
    ..c-Jun, another key regulator of eyelid closure, was present and phosphorylated in eyelid periderm cells at the time of ..
  88. doi Fra-1/AP-1 impairs inflammatory responses and chondrogenesis in fracture healing
    Toru Yamaguchi
    Department of Orthopedic Surgery, School of Medicine, Keio University, Shinjuku ku, Tokyo, Japan
    J Bone Miner Res 24:2056-65. 2009
    ..These data suggest that the Fra-1-containing transcription factor AP-1 inhibits fracture-induced endochondral ossification and bony bridge formation presumably through suppression of inflammation-induced chondrogenesis...
  89. pmc Akt-dependent Pp2a activity is required for epidermal barrier formation during late embryonic development
    Ryan F L O'Shaughnessy
    Centre for Cutaneous Research, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, UK
    Development 136:3423-31. 2009
    ..Akt signaling increased as the barrier wave crossed epidermis and Jun was transiently dephosphorylated...
  90. pmc BMP7 promotes proliferation of nephron progenitor cells via a JNK-dependent mechanism
    Ulrika Blank
    Department of Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA
    Development 136:3557-66. 2009
    ..find that BMP7 directly and rapidly activates JNK signaling in nephron progenitors resulting in phosphorylation of Jun and ATF2 transcription factors...
  91. pmc TNFalpha shedding and epidermal inflammation are controlled by Jun proteins
    Juan Guinea-Viniegra
    Cancer Cell Biology Programme, Centro Nacional de Investigaciones, Oncológicas CNIO, E 28029 Madrid, Spain
    Genes Dev 23:2663-74. 2009
    Inducible epidermal deletion of JunB and c-Jun in adult mice causes a psoriasis-like inflammatory skin disease. Increased levels of the proinflammatory cytokine TNFalpha play a major role in this phenotype...
  92. pmc Systemic anti-VEGF treatment strongly reduces skin inflammation in a mouse model of psoriasis
    Helia B Schonthaler
    Banco Bilbao Vizcaya Argentaria BBVA Foundation, Cancer Cell Biology Programme, Centro Nacional de Investigaciones Oncologicas, 28029 Madrid, Spain
    Proc Natl Acad Sci U S A 106:21264-9. 2009
    ..Simultaneous deletion of JunB and c-Jun (DKO*) in the epidermis of adult mice leads to a psoriasis-like phenotype with hyper- and parakeratosis and ..
  93. pmc Microtubule stabilization by bone morphogenetic protein receptor-mediated scaffolding of c-Jun N-terminal kinase promotes dendrite formation
    Monika Podkowa
    Department of Biochemistry and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada
    Mol Cell Biol 30:2241-50. 2010
    ..BMP7 rapidly activates c-Jun N-terminal kinases (JNKs), known regulators of microtubule dynamics, and we show that JNKs associate with the ..
  94. pmc A dominant-negative c-jun mutant inhibits lung carcinogenesis in mice
    Jay W Tichelaar
    Department of Surgery, The Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Cancer Prev Res (Phila) 3:1148-56. 2010
    ..We then used a transgenic mouse model directing conditional expression of the dominant-negative c-jun mutant TAM67 in lung epithelial cells to determine the effect of AP-1 inhibition on mouse lung tumorigenesis...
  95. pmc C-jun inhibits mammary apoptosis in vivo
    Sanjay Katiyar
    Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Mol Biol Cell 21:4264-74. 2010
    c-jun, which is overexpressed in a number of human cancers encodes a critical component of the AP-1 complex. c-jun has been shown to either induce or inhibit cellular apoptosis...
  96. doi Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun
    Joerg D Hoeck
    Mammalian Genetics Laboratory, Cancer Research UK London Research Institute, London, UK
    Nat Neurosci 13:1365-72. 2010
    ..accumulation of two SCF(Fbw7) substrates, the transcription factors active Notch1 and N-terminally phosphorylated c-Jun. Genetic and pharmacological rescue experiments identified c-Jun as a key substrate of Fbw7 in controlling ..
  97. doi c-JUN promotes BCR-ABL-induced lymphoid leukemia by inhibiting methylation of the 5' region of Cdk6
    Karoline Kollmann
    Institute of Pharmacology, Center of Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna, Austria
    Blood 117:4065-75. 2011
    The transcription factor c-JUN and its upstream kinase JNK1 have been implicated in BCR-ABL-induced leukemogenesis...
  98. pmc DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity
    Arundhati Sengupta Ghosh
    Neurodegeneration Laboratories, Department of Neuroscience, Genentech, Inc, South San Francisco, CA 94080, USA
    J Cell Biol 194:751-64. 2011
    The c-Jun N-terminal kinase (JNK) signaling pathway is essential for neuronal degeneration in multiple contexts but also regulates neuronal homeostasis...
  99. doi c-Jun is essential for the induction of Il-1β gene expression in in vitro activated Bergmann glial cells
    Lidia Albanito
    Institut for Clinical Neurobiology, University of Wurzburg, D 97078 Wurzburg, Germany
    Glia 59:1879-90. 2011
    In the central nervous system (CNS), the c-Jun transcription factor has been mainly studied in neuronal cells and coupled to apoptotic and regenerative pathways following brain injury...
  100. doi The transcription factor c-Jun protects against sustained hepatic endoplasmic reticulum stress thereby promoting hepatocyte survival
    Matthias Fuest
    Department of Medicine II, University Hospital Freiburg, Freiburg, Germany
    Hepatology 55:408-18. 2012
    ..ER stress results in the activation of several intracellular signaling pathways including Jun N-terminal kinase (JNK)...
  101. pmc Neuronal c-Jun is required for successful axonal regeneration, but the effects of phosphorylation of its N-terminus are moderate
    Crystal A Ruff
    Perinatal Brain Repair Group, Inst Women s Health, University College London, London, UK
    J Neurochem 121:607-18. 2012
    Although neural c-Jun is essential for successful peripheral nerve regeneration, the cellular basis of this effect and the impact of c-Jun activation are incompletely understood...

Research Grants9

  1. FORMAL METHODS APPLIED TO BIOLOGICAL SIGNALING NETWORKS
    Keith Laderoute; Fiscal Year: 2006
    ..abstract_text> ..
  2. HYPOXIC STRESS MECHANISMS IN RADIATION AND CHEMOTHERAPY
    Keith Laderoute; Fiscal Year: 2009
    ..An understanding of these MTF-1-dependent properties should aid in the development of novel prognostic and new modalities for neoplastic diseases. ..
  3. ROLE OF AMPK IN TUMOR DEVELOPMENT AND THERAPY
    Keith R Laderoute; Fiscal Year: 2010
    ..Ultimately, we intend to determine whether the AMPK "emergency stress response" can be exploited for the therapy or prognosis of human cancer. ..
  4. IRON, CALCIUM AND OXIDATIVE STRESS IN LUNG INJURY
    Xi Huang; Fiscal Year: 2001
    ..By determining the role of calcite, it is possible to propose alternative methods for lung disease prevention. ..
  5. REGULATION OF REPRODUCTIVE PROCESSES
    DOUGLAS STOCCO; Fiscal Year: 2003
    ..abstract_text> ..
  6. Poly (ADP-Ribose) synthetase in expression of endothelia
    Basilia Zingarelli; Fiscal Year: 2003
    ..abstract_text> ..
  7. MEKK2/3-MEK5 Interaction/Activation/ERK5 Pathway(RMI)
    BRUCE CUEVAS; Fiscal Year: 2005
    ....
  8. Role of Estrogen and Iron in Breast Cancer
    Xi Huang; Fiscal Year: 2008
    ..We expect to show that iron plays an important role in estrogen-dependent BC and this new direction of research may greatly benefit the health of female baby- boomers. [unreadable] [unreadable] [unreadable]..
  9. Utilization of calcite for the reduction of coal mine dust toxicity
    Xi Huang; Fiscal Year: 2010
    ..This innovative dust mitigation strategy to reduce dust toxicity does not require sophisticated engineering breakthrough and could prevent occupational lung diseases in underground coal workers. ..