Jag1

Summary

Gene Symbol: Jag1
Description: jagged 1
Alias: ABE2, Gsfabe2, Htu, Ozz, Ser-1, protein jagged-1, Serrate-1
Species: mouse

Top Publications

  1. pmc Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium
    H Uyttendaele
    Department of Pathology and Obstetrics Gynecology, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 98:5643-8. 2001
  2. pmc Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development
    Frances A High
    Department of Cell and Developmental Biology and Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:1955-9. 2008
  3. doi Notch signaling is required for the maintenance of enteric neural crest progenitors
    Yoshiaki Okamura
    Department of Genetics, SOKENDAI, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Development 135:3555-65. 2008
  4. doi Mesenchymal stromal cells affect cardiomyocyte growth through juxtacrine Notch-1/Jagged-1 signaling and paracrine mechanisms: clues for cardiac regeneration
    Chiara Sassoli
    Dept of Human Anatomy, Histology and Forensic Medicine, University of Florence, Viale G B Morgagni, 85, 50134 Florence, Italy
    J Mol Cell Cardiol 51:399-408. 2011
  5. ncbi Coexpression of Cux-1 and Notch signaling pathway components during kidney development
    Madhulika Sharma
    Department of Anatomy and Cell Biology, and the Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Dev Dyn 231:828-38. 2004
  6. pmc Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1
    Carrie A Ambler
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, UK
    Development 137:3569-79. 2010
  7. pmc Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome
    Jennifer J Hofmann
    Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Development 139:4449-60. 2012
  8. ncbi The role of Pax2 in mouse inner ear development
    Quianna Burton
    National Institute on Deafness and Other Communication Disorders, Bethesda, MD 20892, USA
    Dev Biol 272:161-75. 2004
  9. pmc Jagged1 signals in the postnatal subventricular zone are required for neural stem cell self-renewal
    Yves Nyfeler
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Freiburg, Germany
    EMBO J 24:3504-15. 2005
  10. ncbi Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear
    Rachael Brooker
    Vertebrate Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 133:1277-86. 2006

Scientific Experts

Detail Information

Publications133 found, 100 shown here

  1. pmc Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium
    H Uyttendaele
    Department of Pathology and Obstetrics Gynecology, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 98:5643-8. 2001
    ..Expression of an activated form of Notch4 in embryonic vasculature leads to abnormal vessel structure and patterning, implicating the Notch pathway in phases of vascular development associated with vessel patterning and remodeling...
  2. pmc Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development
    Frances A High
    Department of Cell and Developmental Biology and Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:1955-9. 2008
    The Notch ligand Jagged1 (Jag1) is essential for vascular remodeling and has been linked to congenital heart disease in humans, but its precise role in various cell types of the cardiovascular system has not been extensively investigated...
  3. doi Notch signaling is required for the maintenance of enteric neural crest progenitors
    Yoshiaki Okamura
    Department of Genetics, SOKENDAI, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Development 135:3555-65. 2008
    ....
  4. doi Mesenchymal stromal cells affect cardiomyocyte growth through juxtacrine Notch-1/Jagged-1 signaling and paracrine mechanisms: clues for cardiac regeneration
    Chiara Sassoli
    Dept of Human Anatomy, Histology and Forensic Medicine, University of Florence, Viale G B Morgagni, 85, 50134 Florence, Italy
    J Mol Cell Cardiol 51:399-408. 2011
    ....
  5. ncbi Coexpression of Cux-1 and Notch signaling pathway components during kidney development
    Madhulika Sharma
    Department of Anatomy and Cell Biology, and the Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Dev Dyn 231:828-38. 2004
    ..Taken together, these results suggest that Cux-1 may function in the context of the Notch signaling pathway in multiple tissues during mammalian embryogenesis...
  6. pmc Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1
    Carrie A Ambler
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, UK
    Development 137:3569-79. 2010
    ..We conclude that jagged 1 is a key mediator of non-cell autonomous Notch signalling in skin...
  7. pmc Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome
    Jennifer J Hofmann
    Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Development 139:4449-60. 2012
    ..Here, we demonstrate that endothelial-specific deletion of Jag1 leads to cardiovascular defects in both embryonic and adult mice that are reminiscent of those in Alagille syndrome...
  8. ncbi The role of Pax2 in mouse inner ear development
    Quianna Burton
    National Institute on Deafness and Other Communication Disorders, Bethesda, MD 20892, USA
    Dev Biol 272:161-75. 2004
    ....
  9. pmc Jagged1 signals in the postnatal subventricular zone are required for neural stem cell self-renewal
    Yves Nyfeler
    Department of Molecular Embryology, Max Planck Institute of Immunobiology, Freiburg, Germany
    EMBO J 24:3504-15. 2005
    ..Our findings suggest a central role for Jagged1 in the NSC niche in the SVZ for maintaining a population of NSCs in the postnatal brain...
  10. ncbi Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear
    Rachael Brooker
    Vertebrate Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 133:1277-86. 2006
    ..We have used a Cre-LoxP approach to knock out two of these ligands, Delta1 (Dll1) and Jagged1 (Jag1), in the mouse ear...
  11. ncbi Stromal expression of Jagged 1 promotes colony formation by fetal hematopoietic progenitor cells
    P Jones
    Section of Gene Function and Regulation and Leukaemia Research Fund Centre, Chester Beatty Laboratories, Institute of Cancer Research, London, UK
    Blood 92:1505-11. 1998
    ..These results obtained in vitro table Jagged 1 as a candidate regulator of stem cell fate in the context of stromal microenvironments in vivo...
  12. pmc Compartmentalised expression of Delta-like 1 in epithelial somites is required for the formation of intervertebral joints
    Ingeborg Teppner
    GSF National Research Center for Environment and Health, GmbH, Institute of Experimental Genetics, Neuherberg, Germany
    BMC Dev Biol 7:68. 2007
    ..We did this by overexpressing a functional copy of the Dll1 gene throughout the paraxial mesoderm, in particular in anterior somite compartments, during somitogenesis in transgenic mice...
  13. pmc Mind bomb-1 is essential for intraembryonic hematopoiesis in the aortic endothelium and the subaortic patches
    Mi Jeong Yoon
    Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk 790 784, South Korea
    Mol Cell Biol 28:4794-804. 2008
    ..Interestingly, dll1 and dll4/Jag1 are expressed in the SAPs and the endothelium of the AGM, respectively, where mib1 is detected...
  14. pmc Acheate-scute like 1 (Ascl1) is required for normal delta-like (Dll) gene expression and notch signaling during retinal development
    Branden R Nelson
    Department of Biological Structure, School of Medicine, University of Washington, Seattle, Washington 98195, USA
    Dev Dyn 238:2163-78. 2009
    ..Thus, these results suggest a molecular mechanism whereby attenuated Notch levels coupled with reduced proneurogenic activity in progenitors leads to increased gliogenesis and decreased neurogenesis in the Ascl1-deficient retina...
  15. doi Patched 1 is a crucial determinant of asymmetry and digit number in the vertebrate limb
    Natalie C Butterfield
    The University of Queensland, Institute for Molecular Bioscience, Queensland, Australia
    Development 136:3515-24. 2009
    ..These results establish the importance of the downstream consequences of Hh pathway repression, and identify Ptc1 as a key player in limb patterning even prior to the onset of Shh expression...
  16. ncbi A non-transmembrane form of Jagged-1 regulates the formation of matrix-dependent chord-like structures
    M K Wong
    Division of Hematology Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    Biochem Biophys Res Commun 268:853-9. 2000
    ..These data suggest that J-1 may be able to modulate, in a matrix-dependent manner, the organization of cell to cell interactions including its ability to promote the development of chord-like structures...
  17. pmc The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells
    F N Karanu
    John P Robarts Research Institute, Developmental Stem Cell Biology, and the Department of Microbiology and Immunology, The University of Western Ontario, London, Ontario, Canada
    J Exp Med 192:1365-72. 2000
    ....
  18. ncbi Soluble Jagged 1 represses the function of its transmembrane form to induce the formation of the Src-dependent chord-like phenotype
    D Small
    Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine 04074, USA
    J Biol Chem 276:32022-30. 2001
    ....
  19. pmc Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways
    Shaolin Shi
    Department of Cell Biology, Albert Einstein College Medicine, New York, NY 10461, USA
    Proc Natl Acad Sci U S A 100:5234-9. 2003
    ..Protein O-fucosyltransferase 1 is therefore an essential core member of Notch signaling pathways in mammals...
  20. pmc Dual roles for the Notch target gene Hes-1 in the differentiation of 3T3-L1 preadipocytes
    David A Ross
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6145, USA
    Mol Cell Biol 24:3505-13. 2004
    ..The results presented in this study establish a new target downstream of the Notch-Hes-1 pathway and suggest a dual role for Hes-1 in adipocyte development...
  21. ncbi Notch 2 and Notch 1/3 segregate to neuronal and glial lineages of the developing olfactory epithelium
    Christine Carson
    Department of Zoology, University of British Columbia, Vancouver, BC, Canada
    Dev Dyn 235:1678-88. 2006
    ..Notch 2 and Notch 1/3 may, therefore, have different roles in the commitment and differentiation of neuronal and glial lineages of the OE during development, and the maintenance of non-neuronal phenotypes postnatally...
  22. ncbi Differential regulation of gene expression in the digit forming area of the mouse limb bud by SHH and gremlin 1/FGF-mediated epithelial-mesenchymal signalling
    Lia Panman
    Developmental Genetics, DKBW Centre for Biomedicine, University of Basel Medical School, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Development 133:3419-28. 2006
    ..required to propagate SHH and establish the presumptive digit expression domains of the Notch ligand jagged 1 (Jag1) and 5'Hoxd genes in the distal limb bud mesenchyme...
  23. ncbi Bile duct proliferation in liver-specific Jag1 conditional knockout mice: effects of gene dosage
    Kathleen M Loomes
    Division of Gastroenterology, Hepatology and Nutrition, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Hepatology 45:323-30. 2007
    ..b>Jag1 encodes a ligand in the Notch pathway and has been identified as the disease-causing gene for the developmental ..
  24. ncbi Expression patterns of Jagged, Delta1, Notch1, Notch2, and Notch3 genes identify ligand-receptor pairs that may function in neural development
    C E Lindsell
    Department of Biological Chemistry, UCLA School of Medicine 90095 1737, USA
    Mol Cell Neurosci 8:14-27. 1996
    ..Furthermore, within the ventricular zone of the neural tube and retina, Jagged and Delta 1 were expressed in complementary regions, suggesting that different DSL-Notch combinations may direct the development of distinct neural subtypes...
  25. ncbi Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila
    B Cohen
    Division of Immunology and Cancer Research, Hospital for Sick Children, Toronto, Ontario, Canada
    Nat Genet 16:283-8. 1997
    ..Ectopic expression of murine manic fringe or radical fringe in Drosophila results in phenotypes that resemble those seen in Notch mutants...
  26. ncbi Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo
    S L Dunwoodie
    Department of Mammalian Development, National Institute for Medical Research, Mill Hill, London, UK
    Development 124:3065-76. 1997
    ..We hypothesise that Dll1 is involved in the release of cells from the precursor population and that Dll3 is required later to divert neurons along a specific differentiation pathway...
  27. ncbi Expression patterns of developmental control genes in normal and Engrailed-1 mutant mouse spinal cord reveal early diversity in developing interneurons
    M P Matise
    New York University Medical School, Skirball Institute of Biomolecular Medicine, Developmental Genetics Program, New York, New York 10016, USA
    J Neurosci 17:7805-16. 1997
    ..Rather, it is suggested that En-1 may function to distinguish a subset of interneurons during the later maturation of the spinal cord...
  28. ncbi Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear
    A K Lewis
    Department of Neuroscience, Genentech, Inc, South, San Francisco, CA 94080, USA
    Mech Dev 78:159-63. 1998
    ..Notch2, Notch3, Notch4, and Delta1 are excluded from the inner ear epithelia. These data support the hypothesis that Notch signaling is involved in hair cell differentiation during inner ear morphogenesis...
  29. ncbi Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1
    Y Xue
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609 1500, USA
    Hum Mol Genet 8:723-30. 1999
    ..Mutations in the human JAGGED1 ( JAG1 ) gene, which encodes a ligand for the Notch family of transmembrane receptors, cause the autosomal dominant ..
  30. ncbi Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse
    I B Barrantes
    Amgen Institute, Ontario Cancer Institute, Departments of Medical Biophysics and Immunology University of Toronto 620 University Avenue, Toronto, Ontario, M5G 2C1, Canada
    Curr Biol 9:470-80. 1999
    ....
  31. ncbi Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods
    K Shimizu
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, 113 8655 Japan
    J Biol Chem 274:32961-9. 1999
    ..Finally, solid-phase binding assay showed that Jagged1 binds to Notch1 and Notch3 in addition to Notch2, suggesting that mJagged1 is a ligand for multiple Notch receptors...
  32. pmc Notch signaling is essential for vascular morphogenesis in mice
    L T Krebs
    The Jackson Laboratory, Bar Harbor, Maine 04609 USA
    Genes Dev 14:1343-52. 2000
    ....
  33. pmc Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2
    K Shimizu
    Departments of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Japan
    Mol Cell Biol 20:6913-22. 2000
    ..Moreover, the findings of rapid cleavage, nuclear translocation, and phosphorylation of Notch2 after ligand binding facilitate the understanding of the Notch signaling...
  34. ncbi Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation
    B McCright
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Development 128:491-502. 2001
    ..The Notch ligand encoded by the Jag1 gene was expressed in developing glomeruli in cells adjacent to Notch2-expressing cells...
  35. pmc The Notch ligand Jagged1 is required for inner ear sensory development
    A E Kiernan
    Medical Research Council Institute of Hearing Research, University Park, Nottingham NG7 2RD, United Kingdom
    Proc Natl Acad Sci U S A 98:3873-8. 2001
    ..However, one of the Notch ligands, Jagged1 (Jag1), does not show an expression pattern wholly consistent with a role in lateral inhibition, as it marks the sensory ..
  36. pmc Members of the Jagged/Notch gene families are expressed in injured arteries and regulate cell phenotype via alterations in cell matrix and cell-cell interaction
    V Lindner
    Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine, USA
    Am J Pathol 159:875-83. 2001
    ..We suggest that Jagged regulation of cell-cell and cell-matrix interactions may contribute to the control of cell migration in situations of tissue remodeling in vivo...
  37. ncbi Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels
    N Villa
    Department of Biological Chemistry, UCLA, Los Angeles, CA 90095 1737, USA
    Mech Dev 108:161-4. 2001
    ..These findings identify an aspect of Notch signaling that could contribute to the mechanism by which this pathway modulates vascular morphogenesis...
  38. ncbi A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency
    Brent McCright
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Development 129:1075-82. 2002
    ..Alagille syndrome is caused by mutations in the Jagged 1 (JAG1) gene, which encodes a ligand for Notch family receptors...
  39. pmc Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells
    Seiji Hitoshi
    Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Genes Dev 16:846-58. 2002
    ..These data are consistent with a role for Notch signaling in the maintenance of the neural stem cell, and inconsistent with a role in a neuronal/glial fate switch...
  40. ncbi FGFR1 is required for the development of the auditory sensory epithelium
    Ulla Pirvola
    Institute of Biotechnology, 00014 University of Helsinki, Helsinki, Finland
    Neuron 35:671-80. 2002
    ..Our data also suggest that FGFR1 might have a distinct later role in intercellular signaling within the differentiating auditory sensory epithelium...
  41. ncbi Lack of pendrin expression leads to deafness and expansion of the endolymphatic compartment in inner ears of Foxi1 null mutant mice
    Malin Hulander
    Medical Genetics, Department of Medical Biochemistry, Institute of Anatomy and Cell Biology, Goteborg University, Box 440, SE 405 30 Goteborg, Sweden
    Development 130:2013-25. 2003
    ..this regulation could be mediated by absence of a specific endolymphatic cell type--FORE (forkhead related) cells--expressing Foxi1, Pds, Coch and Jag1. Thus, mutations in FOXI1 could prove to cause a Pendred syndrome-like human deafness.
  42. pmc The distribution of Notch receptors and their ligands during articular cartilage development
    A J Hayes
    Cardiff School of Biosciences, Cardiff University, PO Box 911 Museum Avenue, Cardiff, UK
    J Anat 202:495-502. 2003
    ..Mechanisms by which these processes are controlled are discussed in light of recent advances in the understanding of Notch signalling pathways...
  43. ncbi Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation
    Michela Noseda
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada
    Circ Res 94:910-7. 2004
    ....
  44. ncbi Consequences of Notch-mediated induction of Jagged1
    David A Ross
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6145, USA
    Exp Cell Res 296:173-82. 2004
    ..The induced Jagged1 had no apparent autocrine effects on Notch signaling but could promote signaling in naïve cells. These results describe a mechanism through which Notch signaling can be relayed from cell to cell...
  45. ncbi Notch signaling controls hepatoblast differentiation by altering the expression of liver-enriched transcription factors
    Naoki Tanimizu
    Stem Cell Regulation, Kanagawa Academy of Science and Technology, Teikyo University Biotechnology Research Center, 907 Nogawa, Kawasaki, 216 0001, Japan
    J Cell Sci 117:3165-74. 2004
    ..These results suggest that the Notch signaling contributes to form a network of these transcription factors suitable for cholangiocyte differentiation...
  46. ncbi Math1 regulates development of the sensory epithelium in the mammalian cochlea
    Chad Woods
    Section on Developmental Neuroscience, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Porter Neuroscience Research Center, Building 35, Bethesda, Maryland 20892, USA
    Nat Neurosci 7:1310-8. 2004
    ..These results show that Math1 functions in the developing cochlea to initiate both inductive and inhibitory signals that regulate the overall formation of the sensory epithelia...
  47. ncbi Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation
    Stephane J C Mancini
    Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066 Epalinges, Switzerland
    Blood 105:2340-2. 2005
    ..In contrast to earlier reports, these data exclude an essential role for Jagged1-mediated Notch signaling during hematopoiesis...
  48. pmc Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1
    Liang Tung Yang
    Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1737, USA
    Mol Biol Cell 16:927-42. 2005
    ....
  49. ncbi The role of notch signaling in the development of intrahepatic bile ducts
    Yuzo Kodama
    Department of Gastroenterology and Hepatology, Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Gastroenterology 127:1775-86. 2004
    ..The mechanism underlying the contribution of the Notch signaling pathway to IHBD formation, however, remains unknown. Here we investigated the role of Notch signaling in IHBD development...
  50. ncbi RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells
    Alex Robert-Moreno
    Centre Oncologia Molecular, IDIBELL Institut de Recerca Oncologica, Hospitalet, Barcelona 08907, Spain
    Development 132:1117-26. 2005
    ..Taken together, these data strongly suggest that activation of Gata2 expression by Notch1/RBPjkappa is a crucial event for the onset of definitive hematopoiesis in the embryo...
  51. ncbi The extracellular matrix protein MAGP-2 interacts with Jagged1 and induces its shedding from the cell surface
    Leslie C Nehring
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Washington University, St Louis, Missouri 63110, USA
    J Biol Chem 280:20349-55. 2005
    ....
  52. pmc The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear
    Amy E Kiernan
    The Jackson Laboratory, Bar Harbor, Maine, USA
    PLoS Genet 2:e4. 2006
    ..However, another Notch ligand, JAG1, is expressed early in the sensory patches prior to cell differentiation, indicating that there may be an earlier ..
  53. ncbi The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development
    Seungwoon Seo
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232 6300, USA
    Dev Biol 294:458-70. 2006
    ..Taken together, our results demonstrate that Foxc transcription factors are novel regulators of arterial cell specification upstream of Notch signaling and lymphatic sprouting during embryonic development...
  54. ncbi Ozzy, a Jag1 vestibular mouse mutant, displays characteristics of Alagille syndrome
    Karen Vrijens
    Department of Medical Genetics, University of Antwerp, B 2610 Antwerp, Belgium
    Neurobiol Dis 24:28-40. 2006
    ..5-cM region on chromosome 2. Subsequently, a 499 T-->A missense mutation was identified in Jag1, leading to a substitution of an evolutionary conserved tryptophane (W167R)...
  55. pmc Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron
    Hui Teng Cheng
    Department of Molecular Biology and Pharmacology at Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8103, St Louis, MO 63110, USA
    Development 134:801-11. 2007
    ..These results establish distinct (non-redundant), instructive roles for Notch receptors in nephron segmentation...
  56. ncbi Six1 is essential for early neurogenesis in the development of olfactory epithelium
    Keiko Ikeda
    Division of Biology, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Tochigi 329 0498, Japan
    Dev Biol 311:53-68. 2007
    ..Our study indicates that Six1 plays critical roles in early neurogenesis by regulating Ngn1, NeuroD, Hes1, and Hes5...
  57. ncbi JAGGED1 and delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitis
    Wassim Elyaman
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 179:5990-8. 2007
    ..Our study provides novel data about differential roles of Notch ligands in regulating inflammation in the periphery as well as in the CNS...
  58. pmc Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements
    Weise Chang
    National Institute on Deafness and Other Communication Disorders, NIH, Rockville, Maryland, United States of America
    PLoS Genet 4:e1000050. 2008
    ..Our results suggest that, in comparison to sensory bristles, crista formation within the inner ear requires an additional step of sensory and non-sensory fate specification...
  59. pmc Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1
    Alex Robert-Moreno
    Centre Oncologia Molecular, IDIBELL, Gran Via km 2 7 Hospitalet, Barcelona, Spain
    EMBO J 27:1886-95. 2008
    ..Taken together, our results indicate that Jagged1-mediated activation of Notch1 is responsible for regulating GATA2 expression in the AGM, which in turn is essential for definitive haematopoiesis in the mouse...
  60. doi Specific Jagged-1 signal from bone marrow microenvironment is required for endothelial progenitor cell development for neovascularization
    Sang Mo Kwon
    Stem Cell Translational Research Laboratory, RIKEN Center For Developmental Biology Institute of Biomedical Research and Innovation, Kobe, Japan
    Circulation 118:157-65. 2008
    ..Despite accumulating evidence that proves the pivotal role of endothelial progenitor cells (EPCs) in ischemic neovascularization, the key signaling cascade that regulates functional EPC kinetics remains unclear...
  61. pmc Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea
    Alain Dabdoub
    Section on Developmental Neuroscience, NIDCD, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:18396-401. 2008
    ..These results demonstrate crucial and diverse roles for Sox2 in the development, specification, and maintenance of sensory cells within the cochlea...
  62. doi Bile duct proliferation in Jag1/fringe heterozygous mice identifies candidate modifiers of the Alagille syndrome hepatic phenotype
    Matthew J Ryan
    Division of Gastroenterology, Hepatology and Nutrition, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Hepatology 48:1989-97. 2008
    ..The syndrome is caused by mutations in JAG1, which encodes a ligand in the Notch signaling pathway, in the majority of cases and mutations in the NOTCH2 ..
  63. doi Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches
    Joanne B Tan
    Hospital for Sick Children Research Institute, Toronto, ON, Canada
    Immunity 30:254-63. 2009
    ..Our study has revealed that the Fringe-Notch2 interaction has important functions in vivo and provides insights into mechanisms regulating MZ B cell development...
  64. doi Jagged1 suppresses collagen-induced arthritis by indirectly providing a negative signal in CD8+ T cells
    Mika Kijima
    Department of Immunology and Parasitology, University of Tokushima Graduate School, Tokushima, Japan
    J Immunol 182:3566-72. 2009
    ..These data indicate that Jagged1 is able to deliver an indirect negative signal into CD8(+) T cells in vivo, which suggests its therapeutic potential in the treatment of CD8(+) T cell-mediated diseases, including rheumatoid arthritis...
  65. pmc Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer
    Veronica Rodilla
    Institut d Investigació Biomèdica de Bellvitge Gran Via km 2 7, Hospitalet and Institut Municipal d Investigacions Mèdiques Hospital del Mar, Dr Aiguader 88, 08003 Barcelona, Spain
    Proc Natl Acad Sci U S A 106:6315-20. 2009
    ..The Notch-specific genetic signature is sufficient to block differentiation and promote vasculogenesis in tumors whereas proliferation depends on both pathways...
  66. doi The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis
    Rui Benedito
    Cancer Research UK London Research Institute, Vascular Development Laboratory, London, UK
    Cell 137:1124-35. 2009
    ....
  67. doi The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling
    Monica Corada
    IFOM, The FIRC Institute of Molecular Oncology Foundation, 20139 Milan, Italy
    Dev Cell 18:938-49. 2010
    ..We propose that early and sustained beta-catenin signaling prevents correct endothelial cell differentiation, altering vascular remodeling and arteriovenous specification...
  68. pmc Notch signaling specifies prosensory domains via lateral induction in the developing mammalian inner ear
    Byron H Hartman
    Department of Biological Structure, University of Washington, Seattle, 98195, USA
    Proc Natl Acad Sci U S A 107:15792-7. 2010
    ..The Notch ligand Jagged1 (Jag1) is expressed in the prosensory domains, and mutation of Jag1 impairs sensory formation...
  69. pmc Patent ductus arteriosus in mice with smooth muscle-specific Jag1 deletion
    Xuesong Feng
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Development 137:4191-9. 2010
    ..Mice with smooth muscle cell-specific deletion of Jag1, which encodes a Notch ligand, die postnatally from patent ductus arteriosus...
  70. pmc BMP signaling is necessary for patterning the sensory and nonsensory regions of the developing mammalian cochlea
    Takahiro Ohyama
    Division of Cell Biology and Genetics, House Ear Institute, Los Angeles, California 90057, USA
    J Neurosci 30:15044-51. 2010
    ..Our results suggest BMP signaling is required for patterning sensory and nonsensory tissue in the mammalian cochlea...
  71. pmc Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells
    Nilay Sethi
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Cancer Cell 19:192-205. 2011
    ..These findings elucidate a stroma-dependent mechanism for Notch signaling in breast cancer and provide rationale for using γ-secretase inhibitors for the treatment of bone metastasis...
  72. pmc Dynamic expression of Lgr5, a Wnt target gene, in the developing and mature mouse cochlea
    Renjie Chai
    Department of Otolaryngology Head and Neck Surgery, Stanford University, CA 94305, USA
    J Assoc Res Otolaryngol 12:455-69. 2011
    ..Their differential expression among cell populations highlights the dynamic but complex distribution of Wnt-activated cells in and around the embryonic and postnatal cochlea...
  73. pmc Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal
    Sung Ho Huh
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS Biol 10:e1001231. 2012
    ..The viability and hearing loss in Fgf20 knockout mice suggest that FGF20 may also be a deafness-associated gene in humans...
  74. pmc Requirements for Jag1-Rbpj mediated Notch signaling during early mouse lens development
    Tien T Le
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Cincinnati, Ohio 45229, USA
    Dev Dyn 241:493-504. 2012
    ..In the mouse, multiple labs have shown that Jag1-Notch signaling is critically required during the second wave of lens fiber cell formation...
  75. pmc Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes
    Chiyoko Sekine
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Tokyo, 113 8421, Japan
    Arthritis Res Ther 14:R45. 2012
    ..However, the responsible Notch ligands have not been identified yet. This study was undertaken to determine the role of individual Notch receptors and ligands in osteoclastogenesis...
  76. pmc The expression of Sox17 identifies and regulates haemogenic endothelium
    Raedun L Clarke
    McEwen Centre for Regenerative Medicine, University Health Network, Toronto, Ontario M5G 1L7, Canada
    Nat Cell Biol 15:502-10. 2013
    ..Taken together, these findings position Sox17 as a key regulator of haemogenic endothelial and haematopoietic development...
  77. ncbi Mouse Serrate-1 (Jagged-1): expression in the developing tooth is regulated by epithelial-mesenchymal interactions and fibroblast growth factor-4
    T A Mitsiadis
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden
    Development 124:1473-83. 1997
    ..This indicates that, at least during tooth development, the expression patterns observed for receptors and ligands in the Notch signaling pathway are generated by different induction mechanisms...
  78. ncbi Analysis of the genetic pathway leading to formation of ectopic apical ectodermal ridges in mouse Engrailed-1 mutant limbs
    C A Loomis
    Ronald O Perelman Department of Dermatology, NYU Medical School, New York, NY 10016, USA
    Development 125:1137-48. 1998
    ..This leads to induction of a second zone of compaction ventrally, which in some cases goes on to form an autonomous secondary AER...
  79. ncbi Expression of Delta1 and Serrate1 (Jagged1) in the mouse inner ear
    A Morrison
    Imperial Cancer Research Fund, London, UK
    Mech Dev 84:169-72. 1999
    ..Delta1 is also expressed: (a) at early stages, at the site of otic neurogenesis; and (b) in scattered cells of the endolymphatic sac, as is Serrate1...
  80. ncbi A mutation in the Lunatic fringe gene suppresses the effects of a Jagged2 mutation on inner hair cell development in the cochlea
    N Zhang
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Curr Biol 10:659-62. 2000
    ..We suggest a model for the action of the Notch signaling pathway in regulating hair cell differentiation in the cochlear sensory epithelium...
  81. ncbi The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti
    H Tsai
    MRC Mammalian Genetics Unit and Mouse Genome Centre, Harwell, Oxon OX11 ORD, UK
    Hum Mol Genet 10:507-12. 2001
    ..We show that the slalom mutant carries a mutation in the Jagged1 gene, implicating a new ligand in the signalling processes that pattern the inner ear neuro-epithelium...
  82. pmc Notch ligands Delta 1 and Jagged1 transmit distinct signals to T-cell precursors
    Sophie M Lehar
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    Blood 105:1440-7. 2005
    ..During these stages, Jagged1 signals can influence the differentiation of immature thymocytes along the natural killer (NK) and gamma delta T-cell lineages...
  83. ncbi Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis
    Soline Estrach
    Keratinocyte Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 133:4427-38. 2006
    ..Deletion of jagged 1 (Jag1) results in inhibition of the hair growth cycle and conversion of hair follicles into cysts of cells undergoing ..
  84. ncbi Monitoring Notch1 activity in development: evidence for a feedback regulatory loop
    Gonzalo del Monte
    Departamento de Inmunologia y Oncologia, Centro Nacional de Biotecnologia CSIC, Campus Cantoblanco, Madrid, Spain
    Dev Dyn 236:2594-614. 2007
    ..We found that Notch1 transcription and activity was severely reduced in zebrafish and mouse Notch pathway mutants, suggesting that vertebrate Notch1 expression is regulated by a positive feedback loop...
  85. ncbi Node and midline defects are associated with left-right development in Delta1 mutant embryos
    Gerhard K H Przemeck
    GSF, Institute of Experimental Genetics, Ingolstaedter Landstr 1, D 85764 Neuherberg, Germany
    Development 130:3-13. 2003
    ..Based on expression analysis in wild-type and mutant embryos, we suggest a model, in which Notch signalling is required for the proper differentiation of node cells and node morphology...
  86. pmc BMP7 inhibits branching morphogenesis in the prostate gland and interferes with Notch signaling
    Irina B Grishina
    Department of Urology, New York University School of Medicine, VAMC, 423 East 23rd Street, 18064 South, New York, NY 10010, USA
    Dev Biol 288:334-47. 2005
    ..Based on our studies, we propose a model that BMP7 inhibits branching morphogenesis in the prostate and limits the number of domains with high Notch1/Hes1 activity...
  87. ncbi Mesenchymal cells are required for functional development of thymic epithelial cells
    Manami Itoi
    Department of Immunology and Microbiology, Meiji University of Oriental Medicine, Hiyoshi cho, Nantan, Kyoto 629 0392, Japan
    Int Immunol 19:953-64. 2007
    ..In addition, our data suggest that mesenchymal cells are required to create the thymic microenvironment and to maintain epithelial architecture and function...
  88. pmc The Notch signaling pathway controls the size of the ocular lens by directly suppressing p57Kip2 expression
    Junling Jia
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 27:7236-47. 2007
    ..We found that the Notch effector Herp2 is expressed in lens epithelium and directly suppresses p57Kip2 expression, providing a molecular link between Notch signaling and the cell cycle control machinery during lens development...
  89. pmc Notch signaling regulates bile duct morphogenesis in mice
    Julie Lozier
    The Jackson Laboratory, Bar Harbor, Maine, United States of America
    PLoS ONE 3:e1851. 2008
    Alagille syndrome is a developmental disorder caused predominantly by mutations in the Jagged1 (JAG1) gene, which encodes a ligand for Notch family receptors. A characteristic feature of Alagille syndrome is intrahepatic bile duct paucity...
  90. pmc Hedgehog signaling regulates sensory cell formation and auditory function in mice and humans
    Elizabeth Carroll Driver
    Section on Developmental Neuroscience, National Institute on Deafness and Other Communication Disorders, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 28:7350-8. 2008
    ..These results suggest that HH signaling plays a key role in the specification, size, and location of the prosensory domain, and therefore of hair cells, within the cochlea...
  91. doi Sall4 regulates cell fate decision in fetal hepatic stem/progenitor cells
    Tsunekazu Oikawa
    Division of Stem Cell Therapy, Center for Stem Cell and Regenerative Medicine, The Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Gastroenterology 136:1000-11. 2009
    ..The expression and functional roles of Sall4 during liver development have not been elucidated. We here provide their first description in hepatoblasts...
  92. pmc Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas
    Maria L Golson
    Department of Genetics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mech Dev 126:687-99. 2009
    ..To determine how the Notch ligand Jagged1 (Jag1) functions during pancreas development, we deleted Jag1 in foregut endoderm and examined postnatal and embryonic ..
  93. pmc Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade
    Jianhui Ma
    Department of Physiology and Pathophysiology, National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences and School of Basic Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People s Republic of China
    J Clin Invest 120:103-14. 2010
    ..Additionally, the STAT3/p63/Notch axis may be a useful target for the treatment of cancers exhibiting hyperactive mTOR signaling...
  94. ncbi [The effects of dendritic cells overexpressing Serrate1 on the differentiation of CD4(+)CD25(+) T cells in asthmatic mice]
    Kun Sun
    Institute of Respiratory Disease of PLA, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China
    Zhonghua Nei Ke Za Zhi 48:756-9. 2009
    ..To observe the effects of dendritic cells (DCs) overexpressing Serrate1 on the differentiation of CD(4)(+)CD(25)(+) T cells and the production of inhibitory cytokines in asthmatic mice...
  95. pmc Endothelial Jarid2/Jumonji is required for normal cardiac development and proper Notch1 expression
    Matthew R Mysliwiec
    Department of Anatomy, School of Medicine and Public Health, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Biol Chem 286:17193-204. 2011
    ..The identification of Jarid2 as a potential regulator of Notch1 signaling has broad implications for many cellular processes including development, stem cell maintenance, and tumor formation...
  96. ncbi Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1
    L Li
    Stowers Institute for Medical Research, Department of Molecular Biotechnology, University of Washington, Seattle 98195 USA
    Nat Genet 16:243-51. 1997
    ..We have mapped the human Jagged1 gene (JAG1), encoding a ligand for the developmentally important Notch transmembrane receptor, to the Alagille syndrome ..
  97. ncbi Notch gene expression during pancreatic organogenesis
    E Lammert
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Mech Dev 94:199-203. 2000
    ..Notch 3 and Notch 4 are expressed in pancreatic mesenchyme and later in endothelial cells. Together these descriptive data comprise a framework for understanding the cellular basis for Notch function during pancreatic development...
  98. ncbi Notch/Delta expression in the developing mouse lung
    L C Post
    Howard Hughes Medical Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Mech Dev 98:95-8. 2000
    ..Here, we report the localization of transcripts of several genes encoding members of the Notch/Delta pathway in the early mouse lung. Most genes are expressed in specific populations and so may contribute to cell diversification...
  99. ncbi The notch receptor and its ligands are selectively expressed during hematopoietic development in the mouse
    L Walker
    UCLA Molecular Biology Institute, Los Angeles, CA 90095 1781, USA
    Stem Cells 19:543-52. 2001
    ..Notch receptors in the adult are most likely utilized by early erythroid precursors and intermediate-stage granulocytes, but not by terminally differentiating cells of either subset...
  100. ncbi Notch1 is required for neuronal and glial differentiation in the cerebellum
    Simone Lütolf
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, CH 8093 Zurich, Switzerland
    Development 129:373-85. 2002
    ..We have also analyzed the effects of Notch1 ablation on gliogenesis in vivo. Our results show that Notch1 is required for both neuron and glia formation and modulates the onset of neurogenesis within the cerebellar neuroepithelium...
  101. ncbi Supernumerary digital flexion creases: an additional clinical manifestation of Alagille syndrome
    Binita M Kamath
    Division of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Med Genet 112:171-5. 2002
    ..The identification of supernumerary digital creases in one-third of AGS probands provides another diagnostic aid and allows for speculation of the role of Jagged1 in the molecular development of digital crease patterns...

Research Grants17

  1. THE ROLE OF NOTCH SIGNALING IN BILE DUCT DEVELOPMENT
    Kathleen Loomes; Fiscal Year: 2004
    ..The recent identification of Jag1 as the disease gene for Alagille syndrome (AGS), a multisystem developmental disorder involving bile duct paucity ..
  2. INTEGRATED DNA SEQUENCING SYSTEM
    Vivian Hook; Fiscal Year: 2002
    ..abstract_text> ..
  3. Skeletal Development and Remodeling in Health, Disease and Aging
    Mone Zaidi; Fiscal Year: 2005
    ..A local forum, which will provide the non-scientific public an informal opportunity to learn about the latest research and therapies emerging in the field, is also planned. ..
  4. CD38/ADP RIBOSYL CYCLASE R0LE IN OSTEOCLAST REGULATION
    Mone Zaidi; Fiscal Year: 2003
    ..Taken together, the studies should provide mechanistic insights into the role of the NAD+/CD38/cADPr/Ca2+ system in osteoclast control. ..
  5. The Role of NFATc1 and Calcineurin in Bone Remodeling
    Mone Zaidi; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  6. Skeletal Biology and Medicine Conference
    Mone Zaidi; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  7. Serpin Protease Inhibitors & Opioid Neuropeptides
    Vivian Hook; Fiscal Year: 2006
    ..Serpin regulation of opioid peptides that mediate analgesia and stress may lead to development of new therapeutic approaches in pain and neurologic disease. ..
  8. The Role of the Notch Pathway in Bile Duct Development
    KATHLEEN MARY LOOMES; Fiscal Year: 2010
    ..Identification of Jag1 as the disease gene for Alagille syndrome (AGS), an autosomal dominant disorder characterized by bile duct paucity ..
  9. BIOSYNTHESIS OF ENKEPHALIN OPIOID PEPTIDES
    Vivian Hook; Fiscal Year: 2009
    ..These findings will enhance our knowledge of the complexity of the endogenous opioid system. ..
  10. POMC Processing and Beta-Endorphine-Related Opioid Peptides
    Vivian Y H Hook; Fiscal Year: 2010
    ..New findings from this project will enhance our knowledge of the complexity of biosynthetic mechanisms for endogenous opioid and neuropeptide systems. ..
  11. The function of Foxi3 in craniofacial development
    Takahiro Ohyama; Fiscal Year: 2008
    ..This project has significant potential for the future study of craniofacial and sensory organ development that will shed a light on the genetic mechanisms of craniofacial birth defects. ..
  12. Phenotypic screen in mouse embryonic for TGF-beta signaling mutations
    JAY VIVIAN; Fiscal Year: 2007
    ..Cell-based mutation screening strategies as developed in this proposal can be applied to any active biochemical pathway in mouse ES cells, to generate mouse lines for analysis in vivo. [unreadable] [unreadable] [unreadable]..
  13. TGF-beta Signaling in Mesenchymal Chondroprogenitors
    Anna Spagnoli; Fiscal Year: 2007
    ..Understanding the role of TGF-beta in MCC biology will provide a framework for therapeutic manipulations to optimize the use of MCC in cartilage diseases. ..
  14. Proteomics/Genomics of Opiate Analgesia and Addiction
    Vivian Hook; Fiscal Year: 2004
    ..Elucidation of distinct pathways will be significant, since it could allow future design of opiate drug regimens that provide effective analgesia, without the tolerance and dependence of addiction. ..
  15. SIGNALING MOLECULES IN BILE DUCT DEVELOPMENT
    Kathleen Loomes; Fiscal Year: 2004
    ..abstract_text> ..
  16. Cell Death in Normal and Diseased Human Epidermis
    Brian Nickoloff; Fiscal Year: 2006
    ..abstract_text> ..