Itpr2

Summary

Gene Symbol: Itpr2
Description: inositol 1,4,5-triphosphate receptor 2
Alias: AI649341, InsP3R-2, InsP3R-5, Ip3r2, Itpr5, insP3R2, inositol 1,4,5-trisphosphate receptor type 2, IP3 receptor, IP3R 2, inositol 1,4,5-triphosphate receptor 5, inositol 1,4,5-trisphosphate type V receptor, inositol trisphosphate receptor type 2, type 2 InsP3 receptor, type 2 inositol 1,4,5-trisphosphate receptor
Species: mouse

Top Publications

  1. ncbi Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization
    J Parrington
    Department of Physiology, Department of Anatomy and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, United Kingdom
    Dev Biol 203:451-61. 1998
  2. doi An antidepressant behaviour in mice carrying a gene-specific InsP3R1, InsP3R2 and InsP3R3 protein knockdown
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, I 50139 Florence, Italy
    Neuropharmacology 55:1156-64. 2008
  3. doi Type 1 and 2 IP3 receptors respond differently to catecholamines and stress
    Olga Krizanova
    Institute of Molecular Physiology and Genetics, Centre of Excellence for Cardiovascular Research SAS, Bratislava, Slovak Republic
    Ann N Y Acad Sci 1148:331-7. 2008
  4. pmc Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes
    Yiguo Wang
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 485:128-32. 2012
  5. pmc Regulation of multidrug resistance-associated protein 2 by calcium signaling in mouse liver
    Laura N Cruz
    Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8019, USA
    Hepatology 52:327-37. 2010
  6. pmc Loss of IP3 receptor-dependent Ca2+ increases in hippocampal astrocytes does not affect baseline CA1 pyramidal neuron synaptic activity
    Jeremy Petravicz
    Curriculum in Neurobiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurosci 28:4967-73. 2008
  7. doi Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors
    Nanaho Fukuda
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Eur J Neurosci 27:2665-75. 2008
  8. pmc The type 2 inositol (1,4,5)-trisphosphate (InsP3) receptor determines the sensitivity of InsP3-induced Ca2+ release to ATP in pancreatic acinar cells
    Hyung Seo Park
    Department of Pharmacology and Physiology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 283:26081-8. 2008
  9. ncbi Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors
    Miwako Iwai
    Division of Molecular Neurobiology, Department of Basic Medical Sciences, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Biol Chem 282:12755-64. 2007
  10. ncbi IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism
    Akira Futatsugi
    Calcium Oscillation, International Cooperative Research Project, Japan Science and Technology Agency, Tokyo 108 0071, Japan
    Science 309:2232-4. 2005

Scientific Experts

  • Nicoletta Galeotti
  • KEN DOUGLAS MCCARTHY
  • Gaetano Santulli
  • Yue Kun Ju
  • Tomoe Y Nakamura
  • S Kaja
  • Fushun Wang
  • Olga Krizanova
  • Chihiro Hisatsune
  • Jason I E Bruce
  • Jeremy Petravicz
  • Akira Futatsugi
  • Mauricio Díaz-Muñoz
  • Katsuhiko Mikoshiba
  • Ju Chen
  • Etsuko Ebisui
  • Keiko Uchida
  • David I Yule
  • Gyorgy Lur
  • Julia V Gerasimenko
  • Hyung Seo Park
  • Matthew J Betzenhauser
  • Eiji Shigetomi
  • Miwako Iwai
  • Gregory A Mignery
  • Ole H Petersen
  • Mark W Sherwood
  • Alexei V Tepikin
  • Akihiro Mizutani
  • Sun Kwang Kim
  • Junhua Yang
  • Kim A Staats
  • Tamara Vervloessem
  • R Martin
  • Joakim Klar
  • Colleen N Feriod
  • Wenting Yang
  • Takaaki Inaba
  • Natesan Sankar
  • Naoko Ogawa
  • Krystal Nizar
  • Kotomi Sugiura
  • Qi Ping Dong
  • Hiroyuki Yamagishi
  • Chihiro Yamagishi
  • Cendra Agulhon
  • Maki Nakazawa
  • Kazunori Kanemaru
  • Nicola Cooley
  • Kunfu Ouyang
  • Joshua T Maxwell
  • Lihua He
  • Gertrudis Perea
  • Yukiko Kuroda
  • Abrahim I Orabi
  • Faye M Drawnel
  • Michael H Nathanson
  • Yiguo Wang
  • Alexander Stanley Thrane
  • Sayako Tamamushi
  • Marta Navarrete
  • Naiyan Chen
  • Marjorie Maillet
  • Norio Takata
  • Jeffery D Molkentin
  • Ramesh N Reddy
  • H Llewelyn Roderick
  • Elizabeth A Woodcock
  • Martin D Bootman
  • Laura N Cruz
  • Oleg V Gerasimenko
  • Hiroyuki Nakayama
  • Roberta Ribeiro Costa
  • Stephen C Tovey
  • Dagmar Harzheim
  • Farah Sheikh
  • Dan S Luciani
  • Stephan Lipp
  • Takafumi Inoue
  • Nanaho Fukuda
  • Hong Zhou
  • Oliver Vasilevski
  • Lothar A Blatter
  • Alejandro Martínez-Gómez
  • R Scott Duncan
  • Takayuki Michikawa
  • Meaghan Stolk
  • Xiaodong Li
  • Cesar Cardenas
  • Matthew R Turvey

Detail Information

Publications79

  1. ncbi Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization
    J Parrington
    Department of Physiology, Department of Anatomy and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, United Kingdom
    Dev Biol 203:451-61. 1998
    ..These studies show that the expression of InsP3R mRNA is developmentally regulated, that Ca2+ signaling at fertilization is mediated exclusively through the type I InsP3R, and that the InsP3R is downregulated after fertilization...
  2. doi An antidepressant behaviour in mice carrying a gene-specific InsP3R1, InsP3R2 and InsP3R3 protein knockdown
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, I 50139 Florence, Italy
    Neuropharmacology 55:1156-64. 2008
    ..InsP3Rl, InsP3R2 and InsP3R3 knockdown mice were obtained to investigate the role of InsP3R isoforms...
  3. doi Type 1 and 2 IP3 receptors respond differently to catecholamines and stress
    Olga Krizanova
    Institute of Molecular Physiology and Genetics, Centre of Excellence for Cardiovascular Research SAS, Bratislava, Slovak Republic
    Ann N Y Acad Sci 1148:331-7. 2008
    ..While the type 1 predominates in neuronal cells and cardiac ganglia, type 2 IP3 receptor is localized mainly in cardiomyocytes...
  4. pmc Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes
    Yiguo Wang
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 485:128-32. 2012
    ....
  5. pmc Regulation of multidrug resistance-associated protein 2 by calcium signaling in mouse liver
    Laura N Cruz
    Section of Digestive Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8019, USA
    Hepatology 52:327-37. 2010
    ..Moreover, the choleretic effect of tauroursodeoxycholic acid (TUDCA) was impaired in InsP(3)R2 KO mice. Finally, ATP increased GFP-Mrp2 fluorescence in the plasma membrane of HepG2 cells, and this also was reduced by BAPTA...
  6. pmc Loss of IP3 receptor-dependent Ca2+ increases in hippocampal astrocytes does not affect baseline CA1 pyramidal neuron synaptic activity
    Jeremy Petravicz
    Curriculum in Neurobiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurosci 28:4967-73. 2008
    ....
  7. doi Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors
    Nanaho Fukuda
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Eur J Neurosci 27:2665-75. 2008
    ..Here we show that type 2 and type 3 IP3 receptors (IP3R2 and IP3R3) play critical roles in olfactory mucus secretion...
  8. pmc The type 2 inositol (1,4,5)-trisphosphate (InsP3) receptor determines the sensitivity of InsP3-induced Ca2+ release to ATP in pancreatic acinar cells
    Hyung Seo Park
    Department of Pharmacology and Physiology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 283:26081-8. 2008
    ..The effects of metabolic stress on intracellular Ca(2+) signals can therefore be determined by the relative amount of InsP(3)R2 expressed in cells...
  9. ncbi Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors
    Miwako Iwai
    Division of Molecular Neurobiology, Department of Basic Medical Sciences, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Biol Chem 282:12755-64. 2007
    ..Moreover, the functional diversity in ligand sensitivity among IP(3)R isoforms originates from at least the structural difference identified on the suppressor domain...
  10. ncbi IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism
    Akira Futatsugi
    Calcium Oscillation, International Cooperative Research Project, Japan Science and Technology Agency, Tokyo 108 0071, Japan
    Science 309:2232-4. 2005
    Type 2 and type 3 inositol 1,4,5-trisphosphate receptors (IP3R2 and IP3R3) are intracellular calcium-release channels whose physiological roles are unknown...
  11. ncbi Endothelin-1-induced arrhythmogenic Ca2+ signaling is abolished in atrial myocytes of inositol-1,4,5-trisphosphate(IP3)-receptor type 2-deficient mice
    Xiaodong Li
    Department of Medicine, University of California San Diego, La Jolla, CalifA 92093 0641, USA
    Circ Res 96:1274-81. 2005
    ..IP3R type-2 (IP3R2) is the predominant IP3R isoform expressed in atrial myocytes...
  12. ncbi Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant
    Miwako Iwai
    Division of Molecular Neurobiology, Department of Basic Medical Sciences, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    J Biol Chem 280:10305-17. 2005
    ....
  13. pmc Calmodulin protects against alcohol-induced pancreatic trypsinogen activation elicited via Ca2+ release through IP3 receptors
    Julia V Gerasimenko
    Medical Research Council Group, School of Biosciences, Cardiff University, Cardiff CF10 3AX, Wales, United Kingdom
    Proc Natl Acad Sci U S A 108:5873-8. 2011
    ..The inositol trisphosphate receptors, required for normal pancreatic stimulus-secretion coupling, are also responsible for the toxic ethanol action. Calmodulin protects by reducing calcium release sensitivity...
  14. pmc The IP3 receptor regulates cardiac hypertrophy in response to select stimuli
    Hiroyuki Nakayama
    Howard Hughes Medical Institute, Cincinnati Children s Hospital Medical Center, 240 Albert Sabin Way, Cincinnati, OH 45229 3039, USA
    Circ Res 107:659-66. 2010
    ..Many prohypertrophic G protein-coupled receptor (GPCR) signaling events lead to IP(3) liberation, although its importance in transducing the hypertrophic response has not been established in vivo...
  15. pmc Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors
    Julia V Gerasimenko
    Medical Research Council Group, Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Liverpool L69 3BX, United Kingdom
    Proc Natl Acad Sci U S A 106:10758-63. 2009
    ....
  16. pmc Increased InsP3Rs in the junctional sarcoplasmic reticulum augment Ca2+ transients and arrhythmias associated with cardiac hypertrophy
    Dagmar Harzheim
    Department of Molecular Signaling, Babraham Institute, Cambridge, CB22 3AT, United Kingdom
    Proc Natl Acad Sci U S A 106:11406-11. 2009
    ..Our data establish that increased InsP(3)R expression is a general mechanism that underlies remodeling of Ca(2+) signaling during heart disease, and in particular, in triggering ventricular arrhythmia during hypertrophy...
  17. ncbi Phosphorylation of inositol 1,4,5-trisphosphate receptors in parotid acinar cells. A mechanism for the synergistic effects of cAMP on Ca2+ signaling
    Jason I E Bruce
    Department of Pharmacology and Physiology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 277:1340-8. 2002
    ..In addition, this report supports the emerging consensus that phosphorylation at the level of the Ca(2+) release machinery is a broadly important mechanism by which cells can regulate Ca(2+)-mediated processes...
  18. pmc Protein kinase A increases type-2 inositol 1,4,5-trisphosphate receptor activity by phosphorylation of serine 937
    Matthew J Betzenhauser
    Department of Pharmacology and Physiology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 284:25116-25. 2009
    ..These results provide a mechanism responsible for the enhanced Ca(2+) signaling following PKA activation in cells that express predominantly InsP(3)R2...
  19. pmc Regulation of inositol 1,4,5-trisphosphate receptors by cAMP independent of cAMP-dependent protein kinase
    Stephen C Tovey
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, United Kingdom
    J Biol Chem 285:12979-89. 2010
    ..We conclude that all three subtypes of IP(3)R are regulated by cAMP independent of PKA. In HEK cells, where IP(3)R2 selectively associates with AC6, G alpha(s) also associates with the AC x IP(3)R signaling junction...
  20. ncbi Inositol (1,4,5)-trisphosphate receptor links to filamentous actin are important for generating local Ca2+ signals in pancreatic acinar cells
    Matthew R Turvey
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 IPD, UK
    J Cell Sci 118:971-80. 2005
    ..Based on these findings, we suggest that IP(3)Rs form links with F-actin in the apical domain and that these links are essential for the generation of local Ca(2+) spikes...
  21. ncbi Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes
    R A Fissore
    Department of Obstetrics Gynecology, Tufts University School of Medicine and New England Medical Center Hospital, Boston, Massachusetts 02111, USA
    Biol Reprod 60:49-57. 1999
    ..Types 1 and 2 isoforms were also present in granulosa cells...
  22. ncbi Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation
    Cesar Cardenas
    Centro de Estudios Moleculares de la Célula, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 7, Chile
    J Cell Sci 118:3131-40. 2005
    ....
  23. doi Distribution and functional role of inositol 1,4,5-trisphosphate receptors in mouse sinoatrial node
    Yue Kun Ju
    School of Medical Sciences F13, University of Sydney, Australia
    Circ Res 109:848-57. 2011
    ..However, in the mammalian sinoatrial node (SAN), where the heart beat originates, the expression and functional activity of IP(3)Rs have not been investigated...
  24. pmc Astrocytes mediate in vivo cholinergic-induced synaptic plasticity
    Marta Navarrete
    Instituto Cajal, Consejo Superior de Investigaciones Científicas Madrid, Spain
    PLoS Biol 10:e1001259. 2012
    ..Therefore, the astrocyte Ca²⁺ signal is necessary for cholinergic-induced synaptic plasticity, indicating that astrocytes are directly involved in brain storage information...
  25. doi Astrocytic Ca(2+) waves mediate activation of extrasynaptic NMDA receptors in hippocampal neurons to aggravate brain damage during ischemia
    Qi Ping Dong
    College of Life Sciences, Peking University, Beijing, China
    Neurobiol Dis 58:68-75. 2013
    ..importance of astrocytic Ca(2+) activity, we tested hippocampal slices from inositol triphosphate receptor type 2 (IP3R2) knock-out mice which abolished the astrocytic Ca(2+) activity...
  26. pmc Mice lacking inositol 1,4,5-trisphosphate receptors exhibit dry eye
    Takaaki Inaba
    Department of Ophthalmology, Keio University School of Medicine, Shinjuku, Tokyo, Japan Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako, Saitama, Japan
    PLoS ONE 9:e99205. 2014
    ..study, we examined tear secretion in mice lacking the inositol 1,4,5-trisphosphate receptor (IP3R) types 2 and 3 (Itpr2-/-;Itpr3-/-double-knockout mice)...
  27. pmc TRPA1 channels are regulators of astrocyte basal calcium levels and long-term potentiation via constitutive D-serine release
    Eiji Shigetomi
    Department of Physiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 33:10143-53. 2013
    ..The findings have broad relevance for the study of astrocyte-neuron interactions by demonstrating how TRPA1 channel-mediated fluxes contribute to astrocyte basal Ca(2+) levels and neuronal function via constitutive D-serine release...
  28. pmc Modulation of the autonomic nervous system and behaviour by acute glial cell Gq protein-coupled receptor activation in vivo
    Cendra Agulhon
    K D McCarthy Department of Pharmacology, University of North Carolina at Chapel Hill, Genetic Medicine Building, CB 7365, Chapel Hill, NC 27599 7365, USA
    J Physiol 591:5599-609. 2013
    ..Our findings reveal an unexpectedly broad role of GFAP(+) glial cells in modulating complex physiology and behaviour in vivo and suggest that these effects are not dependent on IP3-dependent increases in astrocytic Ca(2+). ..
  29. pmc Calcineurin-NFATc regulates type 2 inositol 1,4,5-trisphosphate receptor (InsP3R2) expression during cardiac remodeling
    Natesan Sankar
    From the Department of Cell and Molecular Physiology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois 60153
    J Biol Chem 289:6188-98. 2014
    In heart, the type 2 inositol 1,4,5-triphosphate receptor (InsP3R2) is the predominant isoform expressed and is localized in the nuclear membrane of ventricular myocytes...
  30. doi Akt2- and ETS1-dependent IP3 receptor 2 expression in dendritic cell migration
    Wenting Yang
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 33:222-36. 2014
    ..The mechanisms linking Akt2 activity to migration remained, however, elusive. DC migration is governed by Ca(2+) signaling. We thus explored whether Akt2 regulates DC Ca(2+) signaling...
  31. doi Type 1 and 3 inositol trisphosphate receptors are required for extra-embryonic vascular development
    Keiko Uchida
    Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan Health Center, Keio University, Kanagawa, Japan
    Dev Biol 418:89-97. 2016
    ..This is the first demonstration of the essential role of IP3/IP3Rs signaling in the development of the vasculature at the embryonic-maternal interface. ..
  32. pmc Inositol 1,4,5-trisphosphate receptor type II (InsP3R-II) is reduced in obese mice, but metabolic homeostasis is preserved in mice lacking InsP3R-II
    Colleen N Feriod
    Department of Cellular and Molecular Physiology, Yale University School of Medicine New Haven, Connecticut
    Am J Physiol Endocrinol Metab 307:E1057-64. 2014
    ..Loss of InsP3R-II does impair secretion of bile components; therefore, we suggest that conditions of obesity would lead to a decrease in this Ca(2+)-sensitive process. ..
  33. pmc Abolished InsP3R2 function inhibits sweat secretion in both humans and mice
    Joakim Klar
    J Clin Invest 124:4773-80. 2014
    ..of a homozygous missense mutation in ITPR2, which encodes the type 2 inositol 1,4,5-trisphosphate receptor (InsP3R2), that was present in all affected family members...
  34. pmc The type 2 inositol 1,4,5-trisphosphate receptor, emerging functions for an intriguing Ca²⁺-release channel
    Tamara Vervloessem
    KU Leuven, Laboratory of Molecular and Cellular Signalling, Department of Cellular and Molecular Medicine, Leuven, Belgium
    Biochim Biophys Acta 1853:1992-2005. 2015
    The inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) type 2 (IP3R2) is an intracellular Ca²⁺-release channel located on the endoplasmic reticulum (ER)...
  35. pmc Mitochondrial calcium overload is a key determinant in heart failure
    Gaetano Santulli
    Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032 Helen and Clyde Wu Center for Molecular Cardiology, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032
    Proc Natl Acad Sci U S A 112:11389-94. 2015
    ..In contrast, cardiac-specific deletion of IP3R2 had no major effect on mitochondrial fitness in HF...
  36. doi Circuit-specific signaling in astrocyte-neuron networks in basal ganglia pathways
    R Martin
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    Science 349:730-4. 2015
    ..Therefore, bidirectional astrocyte-neuron signaling selectively occurs between specific subpopulations of astrocytes, neurons, and synapses. ..
  37. pmc Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain
    Sun Kwang Kim
    J Clin Invest 126:1983-97. 2016
    ..We conclude that reawakened astrocytes are a key trigger for S1 circuit rewiring and that this contributes to neuropathic mechanical allodynia...
  38. pmc Astrocytes contribute to synapse elimination via type 2 inositol 1,4,5-trisphosphate receptor-dependent release of ATP
    Junhua Yang
    Department of Neurobiology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou, China
    elife 5:e15043. 2016
    ..Our results uncovered a novel mechanism suggesting that astrocytes release ATP in an IP3R2-dependent manner to regulate synapse elimination.
  39. pmc Genetic ablation of IP3 receptor 2 increases cytokines and decreases survival of SOD1G93A mice
    Kim A Staats
    KU Leuven University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease LIND
    Hum Mol Genet 25:3491-3499. 2016
    ..Higher gene expression of the inositol 1,4,5-trisphosphate receptor 2 gene (ITPR2), encoding the IP3 receptor 2 (IP3R2), was detected in sporadic ALS patients...
  40. ncbi Differential inositol 1,4,5-trisphosphate receptor signaling in a neuronal cell line
    R Scott Duncan
    Department of Pharmacology and Neuroscience, Institute for Aging and Alzheimer s Disease Research, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, United States
    Int J Biochem Cell Biol 39:1852-62. 2007
    ..Here, we report the functional localization of differentially distributed IP3 receptor types in the commonly-used hippocampal cell line HT22...
  41. ncbi Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor
    Chihiro Hisatsune
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    J Biol Chem 282:37225-31. 2007
    ..We conclude that IP3R3 is a principal mediator of sweet, bitter, and umami taste perception and would be a missing molecule linking phospholipase C beta2 to TRPM5 activation...
  42. doi Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction
    Hong Zhou
    Laboratory for Developmental Neurobiology, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Biochem Biophys Res Commun 369:213-9. 2008
    ..Taken together, we concluded that IP(3)R1 plays a predominant role in the function of the vascular smooth muscle in vivo...
  43. ncbi Identification of candidate target genes for EVI-1, a zinc finger oncoprotein, using a novel selection strategy
    J H Kim
    Yale University, Department of Pathology, New Haven, Connecticut 06520 8023, USA
    Oncogene 17:1527-38. 1998
    ..One selected gene is Itpr2, encoding the inositol trisphosphate type two receptor, which is transcriptionally regulated during myelopoiesis...
  44. doi Type 2 inositol 1,4,5-trisphosphate receptor is predominantly involved in agonist-induced Ca(2+) signaling in Bergmann glia
    Sayako Tamamushi
    Division of Molecular Neurobiology, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Neurosci Res 74:32-41. 2012
    ....
  45. pmc Calcium-dependent N-cadherin up-regulation mediates reactive astrogliosis and neuroprotection after brain injury
    Kazunori Kanemaru
    Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 110:11612-7. 2013
    ..We found that type 2 IP3 receptor knockout (IP3R2KO) mice deficient in astrocytic Ca(2+) signaling have impaired reactive astrogliosis and ..
  46. pmc In vivo stimulus-induced vasodilation occurs without IP3 receptor activation and may precede astrocytic calcium increase
    Krystal Nizar
    Neurosciences Graduate Program, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 33:8411-22. 2013
    ..Moreover, an increase in astrocytic intracellular calcium was not required for normal vasodilation in the IP3R2-KO animals.
  47. pmc No contribution of IP3-R(2) to disease phenotype in models of dilated cardiomyopathy or pressure overload hypertrophy
    Nicola Cooley
    Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia
    Circ Heart Fail 6:318-25. 2013
    ..Similar increases in Ins(1,4,5)P3 and IP3-R(2) are caused by transverse aortic constriction...
  48. pmc IP3 receptor type 2 deficiency is associated with a secretory defect in the pancreatic acinar cell and an accumulation of zymogen granules
    Abrahim I Orabi
    Department of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    PLoS ONE 7:e48465. 2012
    ..In this study, we examined the role of IP3R type 2 (IP3R2) using mice deficient in this Ca(2+) release channel (IP3R2(-/-))...
  49. pmc Mutual antagonism between IP(3)RII and miRNA-133a regulates calcium signals and cardiac hypertrophy
    Faye M Drawnel
    Babraham Institute, Babraham, Cambridge CB22 3AT, England, UK
    J Cell Biol 199:783-98. 2012
    ..Consequently, IICR can be considered as both an initiating event and a driving force for pathological remodeling...
  50. pmc General anesthesia selectively disrupts astrocyte calcium signaling in the awake mouse cortex
    Alexander Stanley Thrane
    Division of Glial Disease and Therapeutics, Department of Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 109:18974-9. 2012
    ..We propose that these glial effects may constitute a nonneuronal mechanism for sedative action of anesthetic drugs...
  51. pmc Modulation of inositol 1,4,5-trisphosphate receptor type 2 channel activity by Ca2+/calmodulin-dependent protein kinase II (CaMKII)-mediated phosphorylation
    Joshua T Maxwell
    Department of Cell and Molecular Physiology, Loyola University Chicago, Stritch School of Medicine, Maywood, Illinois 60153, USA
    J Biol Chem 287:39419-28. 2012
    ..The results of this study show that serine 150 of the InsP(3)R2 is phosphorylated by CaMKII and results in a decrease in the channel open probability...
  52. pmc Nucleus basalis-enabled stimulus-specific plasticity in the visual cortex is mediated by astrocytes
    Naiyan Chen
    Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 109:E2832-41. 2012
    ..Collectively, these findings reveal a unique and surprising role for astrocytes in NB-induced stimulus-specific plasticity in the cerebral cortex...
  53. pmc Astrocyte inositol triphosphate receptor type 2 and cytosolic phospholipase A2 alpha regulate arteriole responses in mouse neocortical brain slices
    Lihua He
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 7:e42194. 2012
    ..Here we used inositol trisphosphate receptor type 2 (IP(3)R2) and cytosolic phospholipase A(2) alpha (cPLA(2)α) deficient mice to determine if ..
  54. pmc Cot kinase promotes Ca2+ oscillation/calcineurin-independent osteoclastogenesis by stabilizing NFATc1 protein
    Yukiko Kuroda
    Laboratory of Cell and Tissue Biology, School of Medicine, Keio University, Tokyo, Japan
    Mol Cell Biol 32:2954-63. 2012
    ..We propose that NFAT activation in vivo occurs via phosphorylation-induced protein stabilization, even in the absence of Ca(2+) oscillation and calcineurin activity...
  55. pmc Bergmann glia modulate cerebellar Purkinje cell bistability via Ca2+-dependent K+ uptake
    Fushun Wang
    Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 109:7911-6. 2012
    ..Thus, Bergmann glia play a previously unappreciated role in controlling the membrane potential and thereby the activity of adjacent Purkinje cells...
  56. doi Astrocyte calcium signaling transforms cholinergic modulation to cortical plasticity in vivo
    Norio Takata
    Laboratory for Neuron Glia Circuit and Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Neurosci 31:18155-65. 2011
    ..Our data present coherent lines of in vivo evidence for astrocytic involvement in cortical plasticity. These findings suggest an unexpected role of astrocytes as a gate for cholinergic plasticity in the cortex...
  57. pmc Regulation of Ca²⁺ release through inositol 1,4,5-trisphosphate receptors by adenine nucleotides in parotid acinar cells
    Hyung Seo Park
    University of Rochester Medical Center, Department of Pharmacology and Physiology, University of Rochester, Rochester, New York 14642, USA
    Am J Physiol Gastrointest Liver Physiol 302:G97-G104. 2012
    ..Adenine nucleotide modulation of InsP(3)R in parotid acinar cells likely contributes to the properties of Ca(2+) signals in physiological and pathological conditions...
  58. doi Neuronal calcium sensor-1 promotes immature heart function and hypertrophy by enhancing Ca2+ signals
    Tomoe Y Nakamura
    Department of Molecular Physiology, National Cerebral and Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    Circ Res 109:512-23. 2011
    ..Neuronal calcium sensor-1 (NCS-1) regulates various neuronal functions. Although it is expressed in the heart, very little is known about its cardiac functions...
  59. pmc Novel mechanism of increased Ca2+ release following oxidative stress in neuronal cells involves type 2 inositol-1,4,5-trisphosphate receptors
    S Kaja
    Department of Ophthalmology and BasicMedical Science, University of Missouri, Kansas City, MO 64108, USA
    Neuroscience 175:281-91. 2011
    ....
  60. ncbi Determination of relative amounts of inositol trisphosphate receptor mRNA isoforms by ratio polymerase chain reaction
    H De Smedt
    Laboratory of Physiology, Campus Gasthuisberg O N, K U Leuven, Belgium
    J Biol Chem 269:21691-8. 1994
    ..4% of the total InsP3R mRNA. InsP3-induced Ca2+ release in permeabilized C3H10T1/2 cells was regulated by luminal and cytosolic Ca2+, stimulated by thimerosal, and inhibited by caffeine...
  61. ncbi Immunolocalization of type 2 inositol 1,4,5-trisphosphate receptors in cardiac myocytes from newborn mice
    Kelly D Garcia
    Research Services, Edward Hines Jr Department of Veterans Affairs Hospital, Hines 60141, Chicago, IL 60612, USA
    Am J Physiol Cell Physiol 287:C1048-57. 2004
    ....
  62. ncbi Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex
    A V Faure
    Laboratoire Canaux Ioniques et Signalisation, INSERM E 9931, Departement de Biologie Moleculaire et Structurale, 17 rue des Martyrs, F 38054 Grenoble, France
    Eur J Neurosci 14:1613-22. 2001
    ..Altogether, they provide a molecular basis for analyzing the developmental modulation of calcium signals useful for neurogenesis progression...
  63. ncbi Rat inositol 1,4,5-trisphosphate receptor isoform 2 interacts with itself in its C-terminal portion and upstream of the first transmembrane domain
    F Magnino
    Department of Clinical Pharmacology, University of Bern, Switzerland
    Eur J Biochem 268:5981-8. 2001
    ..These results advance our understanding of the molecular mechanisms that underlie the oligomerization and interactions of the InsP(3)R subunits during the opening/closing of the Ca(2+) channel...
  64. pmc The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity
    C L Pin
    Department of Paediatrics, Child Health Research Institute, University of Western Ontario, London, Ontario N6C 2V5, Canada
    J Cell Biol 155:519-30. 2001
    ..Based on these observations, we propose that Mist1(KO) mice represent a new genetic model for chronic pancreas injury and that the Mist1 protein serves as a key regulator of acinar cell function, stability, and identity...
  65. ncbi IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1
    Meaghan Stolk
    Robarts Research Institute, London, Ontario, Canada
    J Leukoc Biol 80:651-8. 2006
    ..Signaling via IP(3)R may therefore be sufficient to drive essential DC Ca(2+) signaling processes in the absence of RyR expression or function...
  66. pmc Muscle-specific mRNA isoform encodes a protein composed mainly of the N-terminal 175 residues of type 2 Ins(1,4,5)P3 receptor
    A Futatsugi
    CNS Research Laboratories, Shionogi and Co Ltd, 2 5 1 Mishima, Settsu shi, Osaka 566 0022, Japan Shirokanedai, Minato ku, Tokyo 108 8639
    Biochem J 334:559-63. 1998
    ..The N-terminal region of Ins(1,4,5)P3R is suggested to have a role in ligand binding and to interact with the C-terminal channel domain of Ins(1,4,5)P3R itself. TIPR might regulate the Ins(1,4,5)P3 signal pathway in both muscles...
  67. ncbi Expression of IP3 receptor isoforms at the nodes of Ranvier in rat sciatic nerve
    Alejandro Martínez-Gómez
    Laboratory of Neuroscience, School of Medicine, Autonomous University of the State of Mexico UAEMex, Toluca Edo de Mexico, Mexico
    Neuroreport 18:447-50. 2007
    ..Using immunohistochemical techniques, we show that the three isoforms are expressed in sciatic nerve. IP3R1 and IP3R2 are mainly present in the nucleus of Schwann cells. IP3R1 is also expressed in Schmidt-Lanterman incisures...
  68. pmc Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin
    H De Smedt
    Laboratory of Physiology, Campus Gasthuisberg O N, K U Leuven, Belgium
    Biochem J 322:575-83. 1997
    ....
  69. doi A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells
    Roberta Ribeiro Costa
    Department of Physiology, School of Medicine of Ribeirao Preto University of Sao Paulo, 14049 900 Ribeirao Preto, Sao Paulo, Brazil
    Am J Physiol Cell Physiol 299:C316-23. 2010
    ..These results not only broaden our understanding of the role played by calcium in Leydig cells but also show, for the first time, that RyRs have an important role in determining testosterone secretion by the testis...
  70. ncbi Knockdown of the type 2 and 3 inositol 1,4,5-trisphosphate receptors suppresses muscarinic antinociception in mice
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G Pieraccini 6, I 50139 Florence, Italy
    Neuroscience 149:409-20. 2007
    ..A shift to the right of the physostigmine dose-response curve was obtained after anti-type 2 IP3R2 and anti-type 3 IP3R treatments...
  71. doi Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum
    Akira Futatsugi
    Calcium Oscillation, International Cooperative Research Project, Japan Science and Technology Agency, Saitama, Japan
    J Neurochem 105:1153-64. 2008
    ..We conclude that intracellular calcium release via IP(3)R2s and IP(3)R3s promotes the differentiation of GCPs within a specific interval of postnatal development in the cerebellum...
  72. doi Ins(1,4,5)P(3) regulates phospholipase Cbeta1 expression in cardiomyocytes
    Oliver Vasilevski
    Cellular Biochemistry Laboratory, Baker Heart Research Institute, 75 Commercial Road, Melbourne, 3004, Victoria, Australia
    J Mol Cell Cardiol 45:679-84. 2008
    ..We conclude that Ins(1,4,5)P(3) and IP(3)-receptor (type 2) regulate PLCbeta1 and thereby maintain levels of Ins(1,4,5)P(3). This implies some functional significance for Ins(1,4,5)P(3) in the heart...
  73. pmc Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death
    Dan S Luciani
    Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Comlumbia, Canada
    Diabetes 58:422-32. 2009
    ..Here, we examined the effects of stimulating or inhibiting the ER-resident inositol trisphosphate receptors (IP(3)Rs) and the ryanodine receptors (RyRs) on the induction of beta-cell ER stress and apoptosis...
  74. pmc Granulosa cells express three inositol 1,4,5-trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization
    Mauricio Díaz-Muñoz
    Departamento de Neurobiologia Celular y Molecular, Instituto de Neurobiologia, Campus UNAM Juriquilla, Queretaro, Qro, Mexico
    Reprod Biol Endocrinol 6:60. 2008
    ..The aim of this study was to explore the isoforms of IP3Rs expressed in mouse C57BL/6 NHsd granulosa cells, characterizing their intranuclear localization and the relation with other Ca2+-handling proteins...
  75. pmc InsP₃receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences
    Gyorgy Lur
    Department of Cellular and Molecular Physiology, The University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    Biochem J 436:231-9. 2011
    ..However, the InsP₃-releasing secretagogue ACh (acetylcholine) produced a negative modulatory effect on SOCE, suggesting that activated IP₃Rs could have an inhibitory effect on this Ca²⁺ entry mechanism...
  76. pmc Rescue of calcineurin Aα(-/-) mice reveals a novel role for the α isoform in the salivary gland
    Ramesh N Reddy
    Atlanta Veterans Administration Medical Center, Decatur, GA 30322 0001, USA
    Am J Pathol 178:1605-13. 2011
    ..Significantly, these data also provide a mechanism to rescue to adulthood a valuable animal model of calcineurin inhibitor-mediated neuronal and renal toxicities...
  77. pmc Gene knock-outs of inositol 1,4,5-trisphosphate receptors types 1 and 2 result in perturbation of cardiogenesis
    Keiko Uchida
    Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan
    PLoS ONE 5:. 2010
    ..Although the ryanodine receptor type 2, another type of intracellular Ca2+ release channel, has been shown to play a role in embryonic cardiomyocytes, the functions of the IP3Rs in cardiogenesis remain unclear...
  78. pmc Calcium responses mediated by type 2 IP3-receptors are required for osmotic volume regulation of retinal glial cells in mice
    Stephan Lipp
    Paul Flechsig Institute of Brain Research, University of Leipzig, 04109 Leipzig, Germany
    Neurosci Lett 457:85-8. 2009
    ..It is concluded that endogenous calcium signaling mediated by IP(3)R2 is required for the osmotic volume regulation of retinal glial cells...

Research Grants2

  1. ASTROCYTIC REGULATION OF NEURONAL EXCITABILITY IN VIVO
    Ken McCarthy; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  2. Role of Spinal Cord Lamina II Astrocytes in Neurophysiology and Chronic Pain
    KEN DOUGLAS MCCARTHY; Fiscal Year: 2010
    ..In Specific Aim 3 we will test the hypothesis that the activation of astrocytic NF:B, a proinflammatory transcription factor, is important in the development or maintenance of chronic pain. ..