Itgb3

Summary

Gene Symbol: Itgb3
Description: integrin beta 3
Alias: CD61, GP3A, INGRB3, integrin beta-3, GPIIIa, platelet gpIIIa, platelet membrane glycoprotein IIIa
Species: mouse

Top Publications

  1. ncbi Plasminogen activator inhibitor type-1 inhibits insulin signaling by competing with alphavbeta3 integrin for vitronectin binding
    Roser Lopez-Alemany
    Institut de Recerca Oncològica IRO, Centre d Oncologia Molecular, L Hospitalet de Llobregat, Barcelona, Spain
    Eur J Biochem 270:814-21. 2003
  2. doi Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions
    Olivier Rossier
    Interdisciplinary Institute for Neuroscience, University of Bordeaux, UMR 5297, F 33000 Bordeaux, France
    Nat Cell Biol 14:1057-67. 2012
  3. pmc CYR61 regulates BMP-2-dependent osteoblast differentiation through the {alpha}v{beta}3 integrin/integrin-linked kinase/ERK pathway
    Jen Liang Su
    Graduate Institute of Cancer Biology, College of Medicine, and the eGraduate Institute of Basic Medical Science, China Medical University, Taichung 404, Taiwan
    J Biol Chem 285:31325-36. 2010
  4. doi Novel (64)Cu- and (68)Ga-labeled RGD conjugates show improved PET imaging of α(ν)β(3) integrin expression and facile radiosynthesis
    Rebecca A Dumont
    Department of Nuclear Medicine, University Hospital Freiburg, Freiburg, Germany
    J Nucl Med 52:1276-84. 2011
  5. pmc Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin α(V)β(3) engagement and PI3K/pAkt/NFκB signaling
    Raquel Urtasun
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 55:594-608. 2012
  6. pmc Plasminogen activator inhibitor-1 regulates integrin alphavbeta3 expression and autocrine transforming growth factor beta signaling
    Benjamin S Pedroja
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 284:20708-17. 2009
  7. pmc The kinetics of αIIbβ3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy
    Moritz Stolla
    Cardeza Foundation for Hematologic Research and Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Blood 117:1005-13. 2011
  8. ncbi Control of thrombus embolization and fibronectin internalization by integrin alpha IIb beta 3 engagement of the fibrinogen gamma chain
    Heyu Ni
    Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, MA USA
    Blood 102:3609-14. 2003
  9. ncbi SHIP1 and Lyn Kinase Negatively Regulate Integrin alpha IIb beta 3 signaling in platelets
    Mhairi J Maxwell
    Australian Centre for Blood Diseases, Department of Medicine, Monash University, Box Hill Hospital, Victoria 3128, Australia
    J Biol Chem 279:32196-204. 2004
  10. ncbi In vivo imaging of tumour angiogenesis in mice with the alpha(v)beta (3) integrin-targeted tracer 99mTc-RAFT-RGD
    Lucie Sancey
    INSERM U877, Radiopharmaceutiques Biocliniques, Faculte de Medecine, Université de Grenoble, La Tronche, France
    Eur J Nucl Med Mol Imaging 34:2037-47. 2007

Research Grants

Scientific Experts

Detail Information

Publications141 found, 100 shown here

  1. ncbi Plasminogen activator inhibitor type-1 inhibits insulin signaling by competing with alphavbeta3 integrin for vitronectin binding
    Roser Lopez-Alemany
    Institut de Recerca Oncològica IRO, Centre d Oncologia Molecular, L Hospitalet de Llobregat, Barcelona, Spain
    Eur J Biochem 270:814-21. 2003
    ..These results constitute the first demonstration of the interaction of PAI-1 with the insulin response...
  2. doi Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions
    Olivier Rossier
    Interdisciplinary Institute for Neuroscience, University of Bordeaux, UMR 5297, F 33000 Bordeaux, France
    Nat Cell Biol 14:1057-67. 2012
    ..Thus, differential transmission of actin motion to fibronectin occurs through specific integrins within FAs...
  3. pmc CYR61 regulates BMP-2-dependent osteoblast differentiation through the {alpha}v{beta}3 integrin/integrin-linked kinase/ERK pathway
    Jen Liang Su
    Graduate Institute of Cancer Biology, College of Medicine, and the eGraduate Institute of Basic Medical Science, China Medical University, Taichung 404, Taiwan
    J Biol Chem 285:31325-36. 2010
    ....
  4. doi Novel (64)Cu- and (68)Ga-labeled RGD conjugates show improved PET imaging of α(ν)β(3) integrin expression and facile radiosynthesis
    Rebecca A Dumont
    Department of Nuclear Medicine, University Hospital Freiburg, Freiburg, Germany
    J Nucl Med 52:1276-84. 2011
    ..The development of (68)Ga-RGD peptides would be of great utility given the convenience of (68)Ga production and radiolabeling, and (64)Cu-RGD peptides allow for delayed imaging with potentially improved tumor-to-background ratios...
  5. pmc Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin α(V)β(3) engagement and PI3K/pAkt/NFκB signaling
    Raquel Urtasun
    Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 55:594-608. 2012
    ..Last, chronic CCl(4) injection and TAA treatment caused more liver fibrosis to WT than to Opn(-/-) mice and the reverse occurred in Opn(HEP) Tg mice...
  6. pmc Plasminogen activator inhibitor-1 regulates integrin alphavbeta3 expression and autocrine transforming growth factor beta signaling
    Benjamin S Pedroja
    Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 284:20708-17. 2009
    ..6-fold increase in collagen deposition over wild type cells. These data suggest that PAI-1-mediated regulation of alphavbeta3 integrin is critical for the control of TGFbeta signaling and the prevention of fibrotic disease...
  7. pmc The kinetics of αIIbβ3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy
    Moritz Stolla
    Cardeza Foundation for Hematologic Research and Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Blood 117:1005-13. 2011
    ....
  8. ncbi Control of thrombus embolization and fibronectin internalization by integrin alpha IIb beta 3 engagement of the fibrinogen gamma chain
    Heyu Ni
    Center for Blood Research and Department of Pathology, Harvard Medical School, Boston, MA USA
    Blood 102:3609-14. 2003
    ..3) Fibrinogen is internalized through alpha IIb beta 3 engagement of the fibrinogen gamma chain element, and this interaction secondarily controls the fibronectin content of platelets...
  9. ncbi SHIP1 and Lyn Kinase Negatively Regulate Integrin alpha IIb beta 3 signaling in platelets
    Mhairi J Maxwell
    Australian Centre for Blood Diseases, Department of Medicine, Monash University, Box Hill Hospital, Victoria 3128, Australia
    J Biol Chem 279:32196-204. 2004
    ..These studies define a major role for SHIP1 and Lyn as negative regulators of integrin alpha(IIb)beta(3) adhesive and signaling function...
  10. ncbi In vivo imaging of tumour angiogenesis in mice with the alpha(v)beta (3) integrin-targeted tracer 99mTc-RAFT-RGD
    Lucie Sancey
    INSERM U877, Radiopharmaceutiques Biocliniques, Faculte de Medecine, Université de Grenoble, La Tronche, France
    Eur J Nucl Med Mol Imaging 34:2037-47. 2007
    ..We evaluated the potential of the novel radiotracer (99m)Tc-RAFT-RGD for the non-invasive molecular imaging of alpha(v)beta(3) integrin expression in mice models of tumour development...
  11. pmc Heparin promotes platelet responsiveness by potentiating αIIbβ3-mediated outside-in signaling
    Cunji Gao
    Blood Research Institute, Medical College of Wisconsin, Milwaukee, WI, USA
    Blood 117:4946-52. 2011
    ....
  12. pmc β3 integrin-EGF receptor cross-talk activates p190RhoGAP in mouse mammary gland epithelial cells
    Nikolas Balanis
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106, USA
    Mol Biol Cell 22:4288-301. 2011
    ..Our data also suggest that EGFR expressed at high levels has a role in eliciting cell shape changes associated with epithelial-to-mesenchymal transition...
  13. pmc Microglia use multiple mechanisms to mediate interactions with vitronectin; non-essential roles for the highly-expressed αvβ3 and αvβ5 integrins
    Jennifer V Welser-Alves
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Neuroinflammation 8:157. 2011
    ..As these integrins have well-defined roles in activation and phagocytic processes in other cell types, the purpose of the current study was to investigate the contribution of these two integrins in microglial activation...
  14. pmc β3 integrin interacts directly with GluA2 AMPA receptor subunit and regulates AMPA receptor expression in hippocampal neurons
    Karine Pozo
    Medical Research Council Laboratory for Molecular Cell Biology and Cell Biology Unit, University College London, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 109:1323-8. 2012
    ..Our findings identify an integrin family member, β3, as a direct interactor of an AMPAR subunit and provide molecular insights into how this cell-adhesion protein regulates the composition of cell-surface AMPARs...
  15. doi Diet intervention reduces uptake of αvβ3 integrin-targeted PET tracer 18F-galacto-RGD in mouse atherosclerotic plaques
    Antti Saraste
    Nuklearmedizinische Klinik und Poliklinik, Nuklearmedizinische Klinik der TU München, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
    J Nucl Cardiol 19:775-84. 2012
    ..We studied whether diet intervention reduces uptake of α(v)β(3) integrin-targeted positron emission tomography tracer (18)F-galacto-RGD in mouse atherosclerotic plaques...
  16. pmc siRNA-mediated silencing of integrin β3 expression inhibits the metastatic potential of B16 melanoma cells
    Anna Nasulewicz-Goldeman
    Department of Experimental Oncology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 R Weigl Street, 53 114 Wroclaw, Poland
    Oncol Rep 28:1567-73. 2012
    ..These results provide evidence for a direct role of integrin β3 in the adhesion, migration and metastasis processes of mouse melanoma cells and point to the potential therapeutic advantages of siRNAs...
  17. doi PU.1 and NFATc1 mediate osteoclastic induction of the mouse beta3 integrin promoter
    Tania N Crotti
    The New England Baptist Bone and Joint Institute, Department of Rheumatology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Physiol 215:636-44. 2008
    ..1, are involved in regulation of beta(3) integrin expression during osteoclast differentiation and suggest that PU.1 confers specificity to the NFATc1 response to macrophage lineage cells...
  18. pmc Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor
    DeannaLee M Beauvais
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, Madison, WI 53706, USA
    J Exp Med 206:691-705. 2009
    ..Thus, Sdc1 is a critical regulator of these two important integrins during angiogenesis and tumorigenesis, and is inhibited by the novel SSTN peptide...
  19. pmc Impaired platelet aggregation and sustained bleeding in mice lacking the fibrinogen motif bound by integrin alpha IIb beta 3
    K Holmbäck
    Division of Developmental Biology, Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    EMBO J 15:5760-71. 1996
    ..Despite the preservation of clotting function, gamma delta 5/gamma delta 5 mice were unable to control blood loss following a surgical challenge and occasionally developed fatal neonatal bleeding events...
  20. pmc A Glanzmann's mutation in beta 3 integrin specifically impairs osteoclast function
    X Feng
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri, USA
    J Clin Invest 107:1137-44. 2001
    ..Thus similarities and distinctions exist in the mechanisms by which the beta 3 integrin regulates platelets and osteoclasts...
  21. ncbi Role of multiple beta1 integrins in cell adhesion to the disintegrin domains of ADAMs 2 and 3
    Monika Tomczuk
    Department of Cell Biology, University of Virginia, Charlottesville, VA 22908 0732, USA
    Exp Cell Res 290:68-81. 2003
    ....
  22. pmc Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces
    Simone M Schoenwaelder
    Australian Centre for Blood Diseases, Monash University, Alfred Medical Research and Education Precinct, 89 Commercial Road, Melbourne, Victoria 3004, Australia
    J Biol Chem 285:2886-96. 2010
    ..These findings may provide new insight into the potential antithrombotic properties of PI3K p110 beta inhibitors...
  23. pmc Cloning and characterization of developmental endothelial locus-1: an embryonic endothelial cell protein that binds the alphavbeta3 integrin receptor
    C Hidai
    Tokyo Women s Medical College, Tokyo 162, Japan
    Genes Dev 12:21-33. 1998
    ..Del1 is thus a new ligand for the alphavbeta3 integrin receptor and may function to regulate vascular morphogenesis or remodeling in embryonic development...
  24. pmc Imaging chemically modified adenovirus for targeting tumors expressing integrin alphavbeta3 in living mice with mutant herpes simplex virus type 1 thymidine kinase PET reporter gene
    Zhengming Xiong
    Molecular Imaging Program at Stanford, MIPS, Department of Radiology, Stanford University School of Medicine, California 94305 5484, USA
    J Nucl Med 47:130-9. 2006
    ....
  25. ncbi Insulin-like growth factor 1 is a potent stimulator of cervical cancer cell invasiveness and proliferation that is modulated by alphavbeta3 integrin signaling
    Meng Ru Shen
    Department of Pharmacology, National Cheng Kung University, Tainan 704, Taiwan
    Carcinogenesis 27:962-71. 2006
    ..Thus, these data suggest that the signal interaction between IGF-1R and alpha(v)beta3 integrin plays an important role in promoting the development and progression of cervical cancer...
  26. pmc Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo
    Nelson C Di Paolo
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Immunity 31:110-21. 2009
    ..Thus, these data identify IL-1 alpha-IL-1RI as a key pathway allowing for the activation of proinflammatory responses to the virus, independently of its genomic nucleic acid recognition...
  27. ncbi Developmental regulation of integrin expression at the time of implantation in the mouse embryo
    A E Sutherland
    Department of Stomatology, University of California San Francisco 94143
    Development 119:1175-86. 1993
    ..abstract truncated at 400 words)..
  28. ncbi Differential mRNA regulation of integrin subunits alpha V, beta 1, beta 3, and beta 5 during mouse embryonic organogenesis
    S Yamada
    Laboratory of Developmental Biology, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Adhes Commun 3:311-25. 1995
    ..The beta 5 integrin is unique in its degree of tissue-specific mRNA regulation associated with morphogenesis of embryonic organs...
  29. pmc Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival
    K M Hodivala-Dilke
    Howard Hughes Medical Institute, Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Invest 103:229-38. 1999
    ....
  30. ncbi Integrin cytoplasmic tyrosine motif is required for outside-in alphaIIbbeta3 signalling and platelet function
    D A Law
    COR Therapeutics, Inc, South San Francisco, California 94080, USA
    Nature 401:808-11. 1999
    ..Furthermore, they identify the integrin cytoplasmic tyrosine motif as a key mediator of beta-integrin signals and a potential target for new therapeutic agents...
  31. pmc Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts
    K P McHugh
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 105:433-40. 2000
    ..Thus, although it is not required for osteoclastogenesis, the integrin alphavbeta3 is essential for normal osteoclast function...
  32. ncbi Platelets adhere to and translocate on von Willebrand factor presented by endothelium in stimulated veins
    P Andre
    Center for Blood Research and the Department of Pathology, Harvard Medical School, Boston, MA, USA
    Blood 96:3322-8. 2000
    ..It is proposed that this process may rapidly recruit platelets to sites of injury or inflammation in veins...
  33. ncbi Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins
    Louise E Reynolds
    Cell Adhesion and Disease Laboratory, Richard Dimbleby Department, Imperial Cancer Research Fund, St Thomas Hospital, London, UK
    Nat Med 8:27-34. 2002
    ....
  34. ncbi Phosphorylation-dependent interaction of osteopontin with its receptors regulates macrophage migration and activation
    Georg F Weber
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Binney Street, Boston, Massachusetts, USA
    J Leukoc Biol 72:752-61. 2002
    ....
  35. pmc The fibronectin-binding integrins alpha5beta1 and alphavbeta3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis
    Erik H J Danen
    Division of Cell Biology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands
    J Cell Biol 159:1071-86. 2002
    ..Our findings demonstrate that the pattern of fibronectin receptors expressed on a cell dictates the ability of fibronectin to stimulate RhoA-mediated organization of cell matrix adhesions...
  36. pmc c-Fms and the alphavbeta3 integrin collaborate during osteoclast differentiation
    Roberta Faccio
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 111:749-58. 2003
    ..Thus, while c-Fms and alpha(v)beta(3) collaborate in the osteoclastogenic process via shared activation of the ERK/c-Fos signaling pathway, the integrin is essential for matrix degradation...
  37. ncbi Differential expression of beta3 integrin gene in chick and mouse cranial neural crest cells
    Thomas Pietri
    UMR 144 Compartimentation et Dynamique Cellulaire, Centre National de la Recherche Scientifique et Institut Curie, Paris, France
    Dev Dyn 227:309-13. 2003
    ..Therefore, the difference in the beta3 integrin expression suggests that mouse and chicken cranial neural crest cells may have distinct integrin requirements during their ontogenesis...
  38. pmc Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin
    Yuki Hamano
    Center for Matrix Biology, Department of Medicine and Gastroenterology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Cancer Cell 3:589-601. 2003
    ..These results indicate that MMP-generated fragments of basement membrane collagen can have endogenous function as integrin-mediated suppressors of pathologic angiogenesis and tumor growth...
  39. ncbi CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo
    Michael J Ferkowicz
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Development 130:4393-403. 2003
    ..CD41(bright) yolk sac definitive progenitor cells co-express CD61 and bind fibrinogen, demonstrating receptor function...
  40. ncbi Inhibition of alpha(v)beta3 integrin reduces angiogenesis, bone turnover, and tumor cell proliferation in experimental prostate cancer bone metastases
    Jeffrey A Nemeth
    Department of Oncology Research, Centocor, Inc, Malvern, Pennsylvania 19355, USA
    Clin Exp Metastasis 20:413-20. 2003
    ..Together these observations confirm the importance of alpha(v)beta3 in bone metabolism and angiogenesis, and point to the role of these processes in controlling growth of metastatic prostate cancer cells in the bone...
  41. pmc Src kinase activation by direct interaction with the integrin beta cytoplasmic domain
    Elena G Arias-Salgado
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:13298-302. 2003
    ..The data provide a paradigm for integrin regulation of Src and a molecular basis for the similar functional defects of osteoclasts or platelets from mice lacking beta3 integrins or c-Src...
  42. pmc Platelet and osteoclast beta3 integrins are critical for bone metastasis
    Suzanne J Bakewell
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR and Division of Oncology, Washington University School of Medicine, St Louis, MO, USA
    Proc Natl Acad Sci U S A 100:14205-10. 2003
    ..These data demonstrate a critical role for platelet alphaIIbbeta3 in tumor entry into bone and suggest a mechanism by which antiplatelet therapy may be beneficial in preventing the metastasis of solid tumors...
  43. ncbi Elevated Flk1 (vascular endothelial growth factor receptor 2) signaling mediates enhanced angiogenesis in beta3-integrin-deficient mice
    Andrew R Reynolds
    Tumour Biology Laboratory, Cancer Research UK Clinical Centre, Barts and The London, Queen Mary s School of Medicine and Dentistry, John Vane Science Centre, London, United Kingdom
    Cancer Res 64:8643-50. 2004
    ..These data confirm that VEGF signaling via Flk1 is enhanced in beta(3)-integrin-deficient mice and suggests that this increase may mediate the enhanced angiogenesis and tumor growth observed in these mice in vivo...
  44. ncbi Accelerated re-epithelialization in beta3-integrin-deficient- mice is associated with enhanced TGF-beta1 signaling
    L E Reynolds
    Cell Adhesion and Disease Laboratory, Department of Tumour Biology, Cancer Research UK, Bart s and The London, Queen Mary s School of Medicine and Dentistry, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK
    Nat Med 11:167-74. 2005
    ..These data indicate that alpha(v)beta(3)-integrin can suppress TGF-beta1-mediated signaling, thereby controlling the rate of wound healing, and highlight a new mechanism for TGF-beta1 regulation by beta(3)-integrins...
  45. pmc The mechanisms and dynamics of (alpha)v(beta)3 integrin clustering in living cells
    Caroline Cluzel
    Department of Pathology and Immunlogy, Centre Medical Universitaire, 1211 Geneva 4, Switzerland
    J Cell Biol 171:383-92. 2005
    ..Thus, integrin clustering requires the formation of the ternary complex consisting of activated integrins, immobilized ligands, talin, and PI(4,5)P2. The dynamic remodeling of this ternary complex controls cell motility...
  46. ncbi A direct test of potential roles for beta3 and beta5 integrins in growth and metastasis of murine mammary carcinomas
    Daniela Taverna
    Howard Hughes Medical Institute, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cancer Res 65:10324-9. 2005
    ..These data indicate that alphavbeta3 or alphavbeta5 integrins are not essential for tumor growth and progression, although they might play some role in mammary gland development...
  47. ncbi Critical role of beta3 integrin in experimental postmenopausal osteoporosis
    Haibo Zhao
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    J Bone Miner Res 20:2116-23. 2005
    ..Using a lentiviral-based strategy to express beta3 mutants in beta3(-/-) mice, we also show that beta3(S752), but not beta3(Y747/Y759), is important for osteoclastic bone resorption in vivo...
  48. ncbi Non-cytotoxic cobra cardiotoxin A5 binds to alpha(v)beta3 integrin and inhibits bone resorption. Identification of cardiotoxins as non-RGD integrin-binding proteins of the Ly-6 family
    Po Long Wu
    Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu 30043, Taiwan
    J Biol Chem 281:7937-45. 2006
    ..These results identify CTX A5 as a non-RGD integrin-binding protein with therapeutic potential as an integrin antagonist...
  49. pmc Tumor-specific expression of alphavbeta3 integrin promotes spontaneous metastasis of breast cancer to bone
    Erica K Sloan
    Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
    Breast Cancer Res 8:R20. 2006
    ....
  50. pmc Alpha9beta1: a novel osteoclast integrin that regulates osteoclast formation and function
    Hongwei Rao
    Medicine Hematology Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Bone Miner Res 21:1657-65. 2006
    ..Antibody to alpha(9) inhibited OCL formation in human marrow cultures, and OCLs from alpha(9) knockout mice had a defect in actin ring reorganization and an impaired bone resorption capacity...
  51. ncbi Intracranial microenvironment reveals independent opposing functions of host alphaVbeta3 expression on glioma growth and angiogenesis
    Masayuki Kanamori
    Department of Neurological Surgery and The Brain Tumor Research Center, University of California, San Francisco, California 94115 0875, USA
    J Biol Chem 281:37256-64. 2006
    ..Appropriate management of these functions could lead to enhanced efficacy of anti-integrin based therapies for glioma...
  52. pmc Integrin signaling is critical for pathological angiogenesis
    Ganapati H Mahabeleshwar
    Department of Molecular Cardiology, Joseph J Jacobs Center for Thrombosis and Vascular Biology, NB50, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Exp Med 203:2495-507. 2006
    ..These findings provide novel mechanistic insights into the role of integrin-VEGF axis in pathological angiogenesis...
  53. pmc Cooperation between VEGF and beta3 integrin during cardiac vascular development
    Sara M Weis
    Moores UCSD Cancer Center, University of California, San Diego, CA 92093 0803, USA
    Blood 109:1962-70. 2007
    ..These findings show a clear vascular phenotype in the hearts of mice lacking beta3 and suggest this integrin plays a critical role in coronary vascular development and the vascular response to VEGF...
  54. ncbi Beta3 integrin deficiency promotes cardiac hypertrophy and inflammation
    Jie Ren
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
    J Mol Cell Cardiol 42:367-77. 2007
    ..These results suggest that alpha(v)beta(3) expression in bone marrow has a generalized suppressive effect on cardiac inflammation...
  55. pmc Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis
    Ganapati H Mahabeleshwar
    Department of Molecular Cardiology, The Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Circ Res 101:570-80. 2007
    ....
  56. pmc CD44 and beta3 integrin organize two functionally distinct actin-based domains in osteoclasts
    Anne Chabadel
    Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, Ecole Normale Superieure de Lyon, 69364 Lyon, France
    Mol Biol Cell 18:4899-910. 2007
    ..However, although CD44 signals are sufficient to form a SZ, the presence of WIP is indispensable for the formation of a fully functional SZ...
  57. pmc Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus
    Keizo Kanasaki
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Dev Biol 313:584-93. 2008
    ..Collectively, our studies demonstrate that podocyte beta1 integrin and ILK signaling is critical for postnatal development and function of the glomerular filtration apparatus...
  58. ncbi Modification of kidney barrier function by the urokinase receptor
    Changli Wei
    Nephrology Division and Program in Glomerular Disease, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Nat Med 14:55-63. 2008
    ..Blockade of alphavbeta3 integrin reduces podocyte motility in vitro and lowers proteinuria in mice. Our findings show a physiological role for uPAR signaling in the regulation of kidney permeability...
  59. pmc Talin is required for integrin-mediated platelet function in hemostasis and thrombosis
    Brian G Petrich
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 204:3103-11. 2007
    ..These data establish that platelet talin plays a crucial role in hemostasis and provide the first proof that talin is required for the activation and function of mammalian alpha2beta1 and alphaIIbbeta3 integrins in vivo...
  60. doi Kindlin-3 is essential for integrin activation and platelet aggregation
    Markus Moser
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Nat Med 14:325-30. 2008
    ..We have therefore identified Kindlin-3 as a novel and essential element for platelet integrin activation in hemostasis and thrombosis...
  61. pmc Protein phosphatase 2A negatively regulates integrin alpha(IIb)beta(3) signaling
    Francisca C Gushiken
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 283:12862-9. 2008
    ..These studies demonstrate that PP2Ac (alpha) can negatively regulate integrin alpha(IIb)beta(3) signaling by suppressing the ERK1/2 signaling pathway...
  62. pmc Direct Thy-1/alphaVbeta3 integrin interaction mediates neuron to astrocyte communication
    Tamara Hermosilla
    Program of Cell and Molecular Biology, FONDAP, Center for Molecular Studies of the Cell CEMC, Institute of Biomedical Sciences ICBM, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    Biochim Biophys Acta 1783:1111-20. 2008
    ..This interaction was promoted by divalent cations and was species-independent. Together, these results demonstrate that the alphavbeta3 integrin heterodimer interacts directly with Thy-1 present on neuronal cells to stimulate astrocytes...
  63. pmc The Foxc2 transcription factor regulates angiogenesis via induction of integrin beta3 expression
    Hisaki Hayashi
    Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, 2220 Pierce Avenue, Nashville, TN 37232 6300, USA
    J Biol Chem 283:23791-800. 2008
    ..endothelial cells, we identified molecules associated with cell-extracellular matrix interactions, integrin beta3 (Itgb3), integrin beta5 (Itgb5), and fibronectin, as downstream targets of Foxc2...
  64. doi The mammary progenitor marker CD61/beta3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis
    Francois Vaillant
    VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Cancer Res 68:7711-7. 2008
    ..In tumors arising in MMTV-wnt-1 tumors, the luminal epithelial progenitor marker CD61/beta3 integrin identified a cancer stem cell (CSC) population that was highly enriched for tumorigenic capability ..
  65. doi Microglial expression of alphavbeta3 and alphavbeta5 integrins is regulated by cytokines and the extracellular matrix: beta5 integrin null microglia show no defects in adhesion or MMP-9 expression on vitronectin
    Richard Milner
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Glia 57:714-23. 2009
    ..Furthermore, it reveals that the alphavbeta5 integrin is not essential for mediating microglial adhesion and MMP-9 expression in response to vitronectin...
  66. pmc Clustering of alpha(5)beta(1) integrins determines adhesion strength whereas alpha(v)beta(3) and talin enable mechanotransduction
    Pere Roca-Cusachs
    Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 106:16245-50. 2009
    ....
  67. pmc Alphav beta3 integrin limits the contribution of neuropilin-1 to vascular endothelial growth factor-induced angiogenesis
    Stephen D Robinson
    Adhesion and Angiogenesis Laboratory, Tumour Biology Centre, Institute of Cancer, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, United Kingdom
    J Biol Chem 284:33966-81. 2009
    ..Our data suggest that beta3 integrin may, in part, negatively regulate VEGF signaling by sequestering NRP1 and preventing it from interacting with VEGFR2...
  68. pmc G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin "outside-in" signaling
    Haixia Gong
    Department of Pharmacology, University of Illinois at Chicago, 835 South Wolcott Avenue, Room E403, Chicago, IL 60612, USA
    Science 327:340-3. 2010
    ..We conclude that integrins are noncanonical Galpha13-coupled receptors that provide a mechanism for dynamic regulation of RhoA...
  69. pmc Absence of the alpha v beta 3 integrin dictates the time-course of angiogenesis in the hypoxic central nervous system: accelerated endothelial proliferation correlates with compensatory increases in alpha 5 beta 1 integrin expression
    Longxuan Li
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Cereb Blood Flow Metab 30:1031-43. 2010
    ....
  70. pmc Beta3-integrin mediates satellite cell differentiation in regenerating mouse muscle
    Huijie Liu
    Department of Integrative Biology and Pharmacology, University of Texas Health, Science Center, Houston, TX 77030, USA
    FASEB J 25:1914-21. 2011
    ..Thus, β3-integrin is a mediator of satellite cell differentiation in regenerating muscle...
  71. pmc Kindlin-3-mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption
    Sarah Schmidt
    Max Planck Institute of Biochemistry, D 82152 Martinsried, Germany
    J Cell Biol 192:883-97. 2011
    ..These findings show that osteoclasts require their entire integrin repertoire to be regulated by kindlin-3 to orchestrate bone homeostasis...
  72. pmc Integrin-αvβ3 regulates thrombopoietin-mediated maintenance of hematopoietic stem cells
    Terumasa Umemoto
    Institute of Advanced Biomedical Engineering and Science, Tokyo Women s Medical University, Tokyo, Japan
    Blood 119:83-94. 2012
    ..Thus, our findings demonstrate a mechanistic link between β3-integrin and TPO in HSCs, which may contribute to maintenance of LTR activity in vivo as well as during ex vivo culture...
  73. pmc c-Src links a RANK/αvβ3 integrin complex to the osteoclast cytoskeleton
    Takashi Izawa
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Mol Cell Biol 32:2943-53. 2012
    ..Thus, activated RANK prompts two distinct signaling pathways; one promotes osteoclast formation, and the other, in collaboration with c-Src-mediated linkage to αvβ3, organizes the cell's cytoskeleton...
  74. pmc Protein disulfide isomerase capture during thrombus formation in vivo depends on the presence of β3 integrins
    Jaehyung Cho
    Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Blood 120:647-55. 2012
    ..These results indicate that both endothelial and platelet β3 integrins contribute to extracellular PDI binding at the vascular injury site...
  75. pmc Targeted inactivation of β1 integrin induces β3 integrin switching, which drives breast cancer metastasis by TGF-β
    Jenny G Parvani
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106 Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506 Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106
    Mol Biol Cell 24:3449-59. 2013
    ....
  76. ncbi High lung-metastatic variant of human osteosarcoma cells, selected by passage of lung metastasis in nude mice, is associated with increased expression of α(v)β(3) integrin
    Yasunori Tome
    AntiCancer Inc, 7917 Ostrow Street, San Diego, CA 92111, U S A
    Anticancer Res 33:3623-7. 2013
    ..With this highly metastatic variant overexpressing αvβ3 integrin, it will now be possible to further investigate the mechanism by which αvβ3 integrin facilitates metastasis. ..
  77. ncbi ERK1 associates with alpha(v)beta 3 integrin and regulates cell spreading on vitronectin
    Marnie S Roberts
    Department of Biochemistry, University of Leicester, University Road, Leicester LE1 7RH, United Kingdom
    J Biol Chem 278:1975-85. 2003
    ..We propose that alpha(v)beta(3) integrin must recycle to the plasma membrane via the Rab4 pathway and recruit active ERK1 in order to function efficiently...
  78. pmc Increased primary tumor growth in mice null for beta3- or beta3/beta5-integrins or selectins
    Daniela Taverna
    Howard Hughes Medical Institute, Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 101:763-8. 2004
    ..These results implicate cells of the innate immune system, macrophages or perhaps natural killer cells, in each case dependent on integrins and selectins, in tumor suppression...
  79. pmc Fibrinogen inhibits neurite outgrowth via beta 3 integrin-mediated phosphorylation of the EGF receptor
    Christian Schachtrup
    Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 104:11814-9. 2007
    ....
  80. pmc The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation
    Brian G Petrich
    Department of Medicine, UCSD School of Medicine, La Jolla, California 92093 0726, USA
    J Clin Invest 117:2250-9. 2007
    ..Furthermore, they suggest that modulation of beta(3) integrin-talin interactions may provide an attractive target for antithrombotics and result in a reduced risk of pathological bleeding...
  81. pmc Integrin alphavbeta3 acts downstream of insulin in normalization of interstitial fluid pressure in sepsis and in cell-mediated collagen gel contraction
    Oyvind Sverre Svendsen
    Dept of Biomedicine, Univ of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
    Am J Physiol Heart Circ Physiol 295:H555-60. 2008
    ..Our findings suggest a beneficiary effect of insulin for patients with sepsis with regard to the fluid balance, and this effect may in part be due to a normalization of P(IF) by a mechanism involving the integrin alpha(v)beta(3)...
  82. ncbi ETS-1 converts endothelial cells to the angiogenic phenotype by inducing the expression of matrix metalloproteinases and integrin beta3
    N Oda
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    J Cell Physiol 178:121-32. 1999
    ..These results indicate that ETS-1 is a principal regulator that converts ECs to the angiogenic phenotype...
  83. ncbi Epithelial membrane protein-2 regulates surface expression of alphavbeta3 integrin in the endometrium
    Madhuri Wadehra
    Department of Pathology and Laboratory, University of California, Los Angeles, CA 90095, USA
    Dev Biol 287:336-45. 2005
    ....
  84. ncbi CD61 enriches long-term repopulating hematopoietic stem cells
    Terumasa Umemoto
    Institute of Advanced Biomedical Engineering and Science, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Biochem Biophys Res Commun 365:176-82. 2008
    ..Here, we demonstrate that long-term repopulating hematopoietic stem cells (LTR-HSCs) have high expression of CD61 (integrin beta3) within the CD34-KSL population. Approximately 60% of CD34-KSL cells showed high expression of CD61...
  85. pmc Fibrinogen-gamma C-terminal fragments induce endothelial barrier dysfunction and microvascular leak via integrin-mediated and RhoA-dependent mechanism
    Mingzhang Guo
    Division of Research, Department of Surgery, University of California Davis School of Medicine, Sacramento, CA 95817, USA
    Arterioscler Thromb Vasc Biol 29:394-400. 2009
    ..The purposes of this study were to characterize the direct effect of the C-terminal fragment of fibrinogen gamma chain (gammaC) on microvascular endothelial permeability and to examine its molecular mechanism of action...
  86. doi Binding of galectin-1 to αIIbβ₃ integrin triggers "outside-in" signals, stimulates platelet activation, and controls primary hemostasis
    Maria A Romaniuk
    Laboratory of Experimental Thrombosis, Institute of Experimental Medicine IMEX, National Academy of Medicine, Buenos Aires, Argentina
    FASEB J 26:2788-98. 2012
    ..This study identifies a noncanonical mechanism, based on galectin-integrin interactions, for regulating platelet activation...
  87. pmc β3 integrin is dispensable for conditioned fear and hebbian forms of plasticity in the hippocampus
    A B McGeachie
    Medical Research Council Laboratory for Molecular Cell Biology and Cell Biology Unit, University College London, Gower Street, London, UK
    Eur J Neurosci 36:2461-9. 2012
    ..These findings indicate a lack of requirement for ITGβ3 in the two robust forms of hippocampal long-term synaptic plasticity, LTP and LTD, and suggest differential roles for ITGβ1 and ITGβ3 in supporting hippocampal circuit functions...
  88. doi Allogeneic platelet transfusions prevent murine T-cell-mediated immune thrombocytopenia
    Li Guo
    The Toronto Platelet Immunobiology Group
    Blood 123:422-7. 2014
    ..whether allogeneic platelet major histocompatibility complex (MHC) class I transfusions affected antiplatelet CD61-induced ITP...
  89. ncbi Role of integrins during fertilization in mammals
    P Fenichel
    Groupe de Recherche sur l Interaction Gamétique, CJF INSERM 95 04, Faculte de Medecine, Nice, France
    Hum Reprod 13:31-46. 1998
    ..Experimental data suggest that they may act in a similar way during fertilization and may participate to initiation and/or propagation of the calcium signal via stimulation of phospholipase C gamma and inositol trisphosphate production...
  90. ncbi Ubiquitin-related proteins regulate interaction of vimentin intermediate filaments with the plasma membrane
    A L Wu
    Division of Infectious Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Cell 4:619-25. 1999
    ..Transfection of PLICs induces redistribution of vimentin and cell spreading in IAP-expressing cells. This novel connection between plasma membrane and cytoskeleton is likely to be significant in many adhesion-dependent cell functions...
  91. ncbi Beta 1/beta 3 integrin ligation is uncoupled from ERK1/ERK2 activation in cytotoxic T lymphocytes
    Lawrence G Puente
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada
    J Leukoc Biol 73:391-8. 2003
    ....
  92. ncbi Specific alpha v integrin receptors modulate K1735 murine melanoma cell behavior
    Yongjian Yang
    Department of Stomatology, University of California at San Francisco, San Francisco, CA, USA
    Biochem Biophys Res Commun 308:814-9. 2003
    ....
  93. ncbi Alpha5beta1, alphaVbeta3 and the platelet-associated integrin alphaIIbbeta3 coordinately regulate adhesion and migration of differentiating mouse trophoblast cells
    Ujjwal K Rout
    C S Mott Center for Human Growth and Development, Departments of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI 48201 1415, USA
    Dev Biol 268:135-51. 2004
    ..These data demonstrate that trafficking of alphaIIb regulates adhesion between trophoblast cells and fibronectin as invasion of the endometrium commences...
  94. ncbi A digenic cause of cleft lip in A-strain mice and definition of candidate genes for the two loci
    Diana M Juriloff
    Department of Medical Genetics, University of British Columbia, Vancouver, British ColumbiaV6T 1Z3, Canada
    Birth Defects Res A Clin Mol Teratol 70:509-18. 2004
    ..Our previous studies mapped two loci: clf1 on Chr11 and clf2 on Chr13--with a strong genetic maternal effect on the level of risk. Here we test the hypothesis that CL(P) is digenic and identify candidate genes for clf1 and clf2...
  95. pmc Therapeutic expression of the platelet-specific integrin, alphaIIbbeta3, in a murine model for Glanzmann thrombasthenia
    Juan Fang
    Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Blood 106:2671-9. 2005
    ..These results indicate the feasibility of targeting platelets with genetic therapies for better management of patients with inherited bleeding disorders...
  96. ncbi Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo
    H Yang
    Department of Laboratory Medicine and Pathobiology, St Michael s Hospital, University of Toronto, Ottawa, ON, Canada
    J Thromb Haemost 4:2230-7. 2006
    ..Fibrinogen (Fg) has been considered essential for platelet aggregation. However, we recently demonstrated formation of occlusive thrombi in Fg-deficient mice and in mice doubly deficient for Fg and von Willebrand factor (Fg/VWF(-/-))...
  97. ncbi JAM-C regulates tight junctions and integrin-mediated cell adhesion and migration
    Guillaume Mandicourt
    Department of Pathology and Immunology, The University Medical Center, CH 1211 Geneva 4, Switzerland
    J Biol Chem 282:1830-7. 2007
    ..These results highlight an unexpected function for JAM-C in controlling epithelial cell conversion from a static, polarized state to a pro-migratory phenotype...
  98. pmc Forkhead box F1 is essential for migration of mesenchymal cells and directly induces integrin-beta3 expression
    Dmitriy Malin
    The University of Chicago, Division of the Biological Sciences, Department of Medicine, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Mol Cell Biol 27:2486-98. 2007
    ..Foxf1 plays an essential role in mesenchyme migration by transcriptionally regulating Itgbeta3...
  99. ncbi Beta 3 integrins regulate lymphocyte migration and cytokine responses in heart transplant rejection
    A Lacy-Hulbert
    Howard Hughes Medical Institute, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA
    Am J Transplant 7:1080-90. 2007
    ..Hence we provide strong mechanistic evidence supporting previous genetic studies, demonstrate the involvement of beta 3 integrins in both acute and chronic rejection and identify beta 3 as a new target for immunosuppressive therapy...
  100. ncbi CD98hc (SLC3A2) interaction with the integrin beta subunit cytoplasmic domain mediates adhesive signaling
    Gerald W Prager
    Department of Medicine, University of California San Diego, La Jolla, California 92093, USA
    J Biol Chem 282:24477-84. 2007
    ..These studies also provide new insights into how CD98hc may cooperate with other cytoplasmic domain binding proteins to modulate integrin functions and into the evolution of integrin signaling...
  101. pmc Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage specific FAK knockout
    Ian S Hitchcock
    Department of Medicine, University of California San Diego, La Jolla 92093, USA
    Blood 111:596-604. 2008
    ..These studies establish clear roles for FAK in megakaryocyte growth and platelet function, setting the stage for manipulation of this component of the Tpo signaling apparatus for therapeutic benefit...

Research Grants15

  1. Inhibitors of 5alpha-reductase for acne therapy
    Lingna Li; Fiscal Year: 2002
    ..PROPOSED COMMERCIAL APPLICATIONS: Liposomal 4-MA will be developed as a topical selectively targeted therapeutic for acne for which they should be a very market. ..
  2. RHOMOCYCSTEINASE FOR HOMOCYSTEINE ASSAY
    Yuying Tan; Fiscal Year: 2002
    ..The tHCY enzymatic kits for these applications will be ready for commercial launch at this point. PROPOSED COMMERCIAL APPLICATION: Not Available ..
  3. Discovery of novel fluorescent reporter genes
    Ming Zhao; Fiscal Year: 2004
    ..Reporters with spectral properties that can be used for whole-body imaging of tumors in the lung and their metastases will be candidates for further development for numerous applications of multi-color imaging. ..
  4. Enzyme therapy for hyperhomocysteinemia
    Yuying Tan; Fiscal Year: 2005
    ..Phase II results will lead to an IND for MEGC-PEG-rMETase for end stage renal disease patients and other patients with intractable hyperhomocysteinemia and high cardiovascular disease mortality. ..
  5. Imageable tumor-targeting bacteria
    Ming Zhao; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  6. Targeted tumoricidal bacteria
    Ming Zhao; Fiscal Year: 2007
    ..Future human trials of the tumor-killing bacteria can be held after the Phase I and Phase II grant periods are completed. [unreadable] [unreadable] [unreadable]..
  7. Dual-color tumor-host imaging models
    Meng Yang; Fiscal Year: 2007
    ..These models have significant commercial potential for discovery and development of stroma-targeted and anti-angiogenesis drugs. [unreadable] [unreadable] [unreadable]..
  8. Therapeutic hair follicle-derived neurospheres
    Meng Yang; Fiscal Year: 2007
    ..Human hair- follicle bulge cells will be further characterized and developed for therapeutic potential for nerve regeneration in Phase III. [unreadable]..
  9. Orthotopic models of tumor angiogenesis and blood flow
    Meng Yang; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  10. Adenoviral GFP targeting of metastatic human tumors using multiple delivery route
    Hiroyuki Kishimoto; Fiscal Year: 2008
    ..Having obtained these results, we can move forward in the Phase II grant application with experiments to bring OBP-401 to the clinic for use in cancer surgery in human patients. [unreadable] [unreadable] [unreadable]..
  11. Regulation of Src by integrins during metastasis
    Jay Desgrosellier; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  12. DENDTRITIC CELLS, APOPTOTIC BODIES & TRANSPLANT TOLERAN*
    ADRIAN MORELLI; Fiscal Year: 2003
    ..The results may provide new insight into how apoptotic bodies can modulate the Th-driving capacity of DC and determine the therapeutic potential of DC and apoptotic bodies in transplant tolerance. ..
  13. Dendritic Cells with Galectin-1 to Enhance Islet Grafts
    ADRIAN MORELLI; Fiscal Year: 2003
    ..The results may have an important impact on regulation of beta-cell autoimmunity and in other areas of transplantation. ..
  14. Exosomes, Dendritic Cells and Transplant Tolerance
    ADRIAN MORELLI; Fiscal Year: 2007
    ..AIM 3: To investigate the effect of administration of donor MHC + exosomes or recipient DCs exposed to donor MHC + exosomes on heart allograft survival. To compare the effects of donor-MHC + exosomes with donor-MHC + apoptotic cells. ..
  15. Graft Tolerance with Apoptotic Cells and Dendritic Cells
    ADRIAN MORELLI; Fiscal Year: 2008
    ..Aim 3; To optimize the therapeutic effect of donor apoptotic cells on heart allograft survival. To investigate the mechanism(s) of action of donor apoptotic cells in graft recipients. ..