Itgam

Summary

Gene Symbol: Itgam
Description: integrin alpha M
Alias: CD11b/CD18, CR3, CR3A, Cd11b, F730045J24Rik, Ly-40, MAC1, Mac-1, Mac-1a, integrin alpha-M, CD11 antigen-like family member B, CD11B (p170), CR-3 alpha chain, Mac-1 alpha, cell surface glycoprotein MAC-1 alpha subunit, cell surface glycoprotein MAC-1 subunit alpha, complement component receptor 3 alpha-a, complement receptor type 3, leukocyte adhesion receptor MO1, macrophage antigen alpha
Species: mouse

Top Publications

  1. doi Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor
    Shirley Wakselman
    Laboratoire de Biologie Cellulaire de la Synapse, Institut National de Santé et de Recherche Médicale, Unité 789, 75230 Paris Cedex 05, France
    J Neurosci 28:8138-43. 2008
  2. ncbi CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1
    Andreas Zirlik
    Donald W Reynolds Center, Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 115:1571-80. 2007
  3. ncbi The LFA-1 adhesion molecule is required for protective immunity during pulmonary Mycobacterium tuberculosis infection
    Shamik Ghosh
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 176:4914-22. 2006
  4. pmc The integrin Mac-1 (CR3) mediates internalization and directs Bacillus anthracis spores into professional phagocytes
    Claudia R Oliva
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 2170, USA
    Proc Natl Acad Sci U S A 105:1261-6. 2008
  5. doi The calcineurin B subunit induces TNF-related apoptosis-inducing ligand (TRAIL) expression via CD11b-NF-κB pathway in RAW264.7 macrophages
    Zhenyi Su
    Department of Biochemistry and Molecular Biology, Beijing Normal University, Beijing Key Laboratory, Beijing 100875, PR China
    Biochem Biophys Res Commun 417:777-83. 2012
  6. pmc Amino acid sequence of the murine Mac-1 alpha chain reveals homology with the integrin family and an additional domain related to von Willebrand factor
    R Pytela
    Basel Institute for Immunology, Switzerland
    EMBO J 7:1371-8. 1988
  7. ncbi CD11b and intercellular adhesion molecule-1 are involved in pulmonary neutrophil recruitment in lipopolysaccharide-induced airway disease
    Jessica G Moreland
    Division of Critical Care, Department of Pediatrics, University of Iowa, Iowa City 52242, USA
    Am J Respir Cell Mol Biol 27:474-80. 2002
  8. doi The role of Mac-1 (CD11b/CD18) in osteoclast differentiation induced by receptor activator of nuclear factor-kappaB ligand
    Hidetaka Hayashi
    Department of Cellular Physiological Chemistry, Graduate School, Tokyo Medical and Dental University, 1 5 45, Yushima, Tokyo 113 8549, Japan
    FEBS Lett 582:3243-8. 2008
  9. pmc Modulating the expression of IFN regulatory factor 8 alters the protumorigenic behavior of CD11b+Gr-1+ myeloid cells
    Trina J Stewart
    Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 183:117-28. 2009
  10. doi Inhibition of phagocytosis in HIV-1-infected macrophages relies on Nef-dependent alteration of focal delivery of recycling compartments
    Julie Mazzolini
    Institut Cochin, Universite Paris Descartes, Centre National de la Recherche Scientifique Unite Mixte de Recherche 8104, Paris, France
    Blood 115:4226-36. 2010

Research Grants

Scientific Experts

Detail Information

Publications155 found, 100 shown here

  1. doi Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor
    Shirley Wakselman
    Laboratoire de Biologie Cellulaire de la Synapse, Institut National de Santé et de Recherche Médicale, Unité 789, 75230 Paris Cedex 05, France
    J Neurosci 28:8138-43. 2008
    ..that, in the developing hippocampus, apoptotic neurons are contacted by microglia expressing both the integrin CD11b and the immunoreceptor DAP12...
  2. ncbi CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1
    Andreas Zirlik
    Donald W Reynolds Center, Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 115:1571-80. 2007
    ..The present study aimed to characterize the contribution of CD40 signaling to atherogenesis...
  3. ncbi The LFA-1 adhesion molecule is required for protective immunity during pulmonary Mycobacterium tuberculosis infection
    Shamik Ghosh
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 176:4914-22. 2006
    ..To address this question, we infected knockout (KO) mice that have defective expression of CD11a, CD11b, CD18, CD62, CD103, or beta7...
  4. pmc The integrin Mac-1 (CR3) mediates internalization and directs Bacillus anthracis spores into professional phagocytes
    Claudia R Oliva
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 2170, USA
    Proc Natl Acad Sci U S A 105:1261-6. 2008
    ..anthracis spores (WT spores). Conversely, CD11b(-/-) macrophages demonstrated a significant decrease in spore uptake when compared with macrophages from normal ..
  5. doi The calcineurin B subunit induces TNF-related apoptosis-inducing ligand (TRAIL) expression via CD11b-NF-κB pathway in RAW264.7 macrophages
    Zhenyi Su
    Department of Biochemistry and Molecular Biology, Beijing Normal University, Beijing Key Laboratory, Beijing 100875, PR China
    Biochem Biophys Res Commun 417:777-83. 2012
    ..Here, we report that the calcineurin B subunit binds to CD11b on RAW264...
  6. pmc Amino acid sequence of the murine Mac-1 alpha chain reveals homology with the integrin family and an additional domain related to von Willebrand factor
    R Pytela
    Basel Institute for Immunology, Switzerland
    EMBO J 7:1371-8. 1988
    ..In two of these proteins, the homologous domain is likely to be involved in binding to collagen fibrils. Therefore, Mac-1 may also bind to collagen, which could play a role in the interaction of leukocytes with the subendothelial matrix...
  7. ncbi CD11b and intercellular adhesion molecule-1 are involved in pulmonary neutrophil recruitment in lipopolysaccharide-induced airway disease
    Jessica G Moreland
    Division of Critical Care, Department of Pediatrics, University of Iowa, Iowa City 52242, USA
    Am J Respir Cell Mol Biol 27:474-80. 2002
    To better define the roles of CD11b, CD11a, and one of their endothelial cell receptors, intercellular adhesion molecule-1 (ICAM-1), in the lower respiratory tract inflammatory response to inhaled lipopolysaccharide (LPS), we evaluated ..
  8. doi The role of Mac-1 (CD11b/CD18) in osteoclast differentiation induced by receptor activator of nuclear factor-kappaB ligand
    Hidetaka Hayashi
    Department of Cellular Physiological Chemistry, Graduate School, Tokyo Medical and Dental University, 1 5 45, Yushima, Tokyo 113 8549, Japan
    FEBS Lett 582:3243-8. 2008
    Multinuclear osteoclasts are derived from CD11b-positive mononuclear cells in bone marrow and in circulation. FACS sorting experiments showed impaired osteoclastogenesis in RAW264.7 cells with low CD11b expression...
  9. pmc Modulating the expression of IFN regulatory factor 8 alters the protumorigenic behavior of CD11b+Gr-1+ myeloid cells
    Trina J Stewart
    Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 183:117-28. 2009
    b>CD11b(+)Gr-1(+)-expressing cells, termed myeloid-derived suppressor cells, can mediate immunosuppression and tumor progression. However, the intrinsic molecular events that drive their protumorigenic behavior remain to be elucidated...
  10. doi Inhibition of phagocytosis in HIV-1-infected macrophages relies on Nef-dependent alteration of focal delivery of recycling compartments
    Julie Mazzolini
    Institut Cochin, Universite Paris Descartes, Centre National de la Recherche Scientifique Unite Mixte de Recherche 8104, Paris, France
    Blood 115:4226-36. 2010
    ..We conclude that HIV-1 impairs optimal phagosome formation through Nef-dependent perturbation of the endosomal remodeling relying on AP1. We therefore identified a mechanism of macrophage function down-regulation in infected cells...
  11. pmc LFA-1 and Mac-1 define characteristically different intralumenal crawling and emigration patterns for monocytes and neutrophils in situ
    Ronen Sumagin
    Department of Pharmacology and Physiology, University of Rochester, Rochester, NY 14642, USA
    J Immunol 185:7057-66. 2010
    ..Using function-blocking Abs, we show that these different crawling patterns were due to CD11a/CD18 (LFA-1)- versus CD11b/CD18 (Mac-1)-mediated crawling...
  12. ncbi Mac-1: a macrophage differentiation antigen identified by monoclonal antibody
    T Springer
    Eur J Immunol 9:301-6. 1979
  13. ncbi PU. 1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation
    M C Olson
    Howard Hughes Medical Institute, University of Chicago, Illinois 60637, USA
    Immunity 3:703-14. 1995
    ..1-/- ES cells. However, the expression of genes associated with terminal myeloid differentiation (CD11b, CD64, and M-CSFR) is eliminated in differentiated PU.1-/- ES cells...
  14. pmc Decreased neointimal formation in Mac-1(-/-) mice reveals a role for inflammation in vascular repair after angioplasty
    D I Simon
    Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 105:293-300. 2000
    ..markers of leukocyte activation - in particular, increased expression of the beta2-integrin Mac-1 (alphaMbeta2, or CD11b/CD18), which is responsible for firm leukocyte adhesion to platelets and fibrinogen on denuded vessels - predict ..
  15. ncbi Mac-1 (CD11b/CD18) is essential for Fc receptor-mediated neutrophil cytotoxicity and immunologic synapse formation
    A B van Spriel
    Immunotherapy Laboratory and Medarex Europe, University Medical Center Utrecht, The Netherlands
    Blood 97:2478-86. 2001
    ..Mac-1 (complement receptor type 3, CD11b/CD18) has previously been implicated in receptor cooperation with Fc receptors (FcRs)...
  16. pmc Control of myeloid-specific integrin alpha Mbeta 2 (CD11b/CD18) expression by cytokines is regulated by Stat3-dependent activation of PU.1
    Athanasia D Panopoulos
    Department of Immunology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 277:19001-7. 2002
    ..migration capabilities, we studied inducible expression of the myeloid-specific marker, integrin alpha(M)beta(2) (CD11b/CD18, Mac-1), in the myeloid cell line, 32D...
  17. ncbi Modulation of Mac-1 (CD11b/CD18)-mediated adhesion by the leukocyte-specific protein 1 is key to its role in neutrophil polarization and chemotaxis
    Chunjie Wang
    Cellular and Molecular Biology Division, Toronto Western Research Institute, Canada
    J Immunol 169:415-23. 2002
    ..These results suggest that LSP1 regulates the function of Mac-1 (CD11b/CD18), which binds only to fibrinogen and ICAM-1 among the substrates we tested...
  18. ncbi Contributions of LFA-1 and Mac-1 to brain injury and microvascular dysfunction induced by transient middle cerebral artery occlusion
    Thiruma V Arumugam
    Dept of Molecular and Cellular Physiology, Louisiana State Univ Health Sciences Center, 1500 Kings Highway, Shreveport, LA 71130, USA
    Am J Physiol Heart Circ Physiol 287:H2555-60. 2004
    ..These findings indicate that both alpha-subunits of the beta2-integrins contribute to the brain injury and blood cell-vessel wall interactions that are associated with transient focal cerebral ischemia...
  19. ncbi Distinct roles of Mac-1 and its counter-receptors in neonatal obstructive nephropathy
    B Lange-Sperandio
    Department of Pediatrics, University of Heidelberg, Heidelberg, Germany
    Kidney Int 69:81-8. 2006
    ..ICAM-1 and its new ligands RAGE and JAM-C are sequentially activated in UUO. Blocking of Mac-1 and its ligands may confer synergistic renoprotective effects in neonatal obstructive nephropathy...
  20. ncbi CD11b+/Gr-1+ myeloid suppressor cells cause T cell dysfunction after traumatic stress
    Valeriya P Makarenkova
    Department of Surgery, University of Pittsburgh Medical Center, PA 15213, USA
    J Immunol 176:2085-94. 2006
    ..We describe that myeloid suppressor cells expressing CD11b(+)/Gr-1(+) markers invade the spleen after traumatic stress and suppress T cell function through the production of ..
  21. pmc Endocytic receptor LRP together with tPA and PAI-1 coordinates Mac-1-dependent macrophage migration
    Chunzhang Cao
    Department of Physiology and Surgery, Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, 21201, USA
    EMBO J 25:1860-70. 2006
    ....
  22. ncbi alpha-Chain phosphorylation of the human leukocyte CD11b/CD18 (Mac-1) integrin is pivotal for integrin activation to bind ICAMs and leukocyte extravasation
    Susanna C Fagerholm
    Division of Biochemistry, Faculty of Biosciences, PB56 Viikinkaari 5, 00014 University of Helsinki, Helsinki, Finland
    Blood 108:3379-86. 2006
    The promiscuous CD11b/CD18 (Mac-1) integrin has important roles in regulating many immunologic functions such as leukocyte adhesion and emigration from the bloodstream via interactions with the endothelial ligands ICAM-1 and ICAM-2, iC3b-..
  23. pmc Lymphocyte function-associated antigen-1-dependent inhibition of corneal wound healing
    Zhijie Li
    Section of Leukocyte Biology, Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030 2600, USA
    Am J Pathol 169:1590-600. 2006
    ..We investigated the contributions of lymphocyte function-associated antigen (LFA)-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) by analyzing wound closure in mice with targeted deletions of CD11a (CD11a-/-) or CD11b (CD11b-/-)...
  24. ncbi CD8+ dendritic cells use LFA-1 to capture MHC-peptide complexes from exosomes in vivo
    Elodie Segura
    Centre de Recherche, Institut Curie, Paris, France
    J Immunol 179:1489-96. 2007
    ..We propose a new role for LFA-1 on DCs, as a receptor for exosomes to favor Ag transfer between DCs in vivo...
  25. pmc Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment
    G One Ahn
    Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 107:8363-8. 2010
    ..We have previously reported that bone marrow-derived CD11b(+) myeloid cells are recruited to tumors grown in irradiated tissues, thereby restoring the vasculature and tumor ..
  26. ncbi A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation
    A Coxon
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Immunity 5:653-66. 1996
    In mice selectively deficient in CD11b/CD18, a beta 2 integrin, chemoattractant-induced leukocyte adhesion to microvascular endothelium in vivo was reduced...
  27. pmc LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient mice
    H Lu
    Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Invest 99:1340-50. 1997
    To better define the specific function of Mac-1 (CD11b) versus LFA-1 (CD11a) and the other CD11 integrins in vivo, we have disrupted murine CD11b by targeted homologous recombination in embryonic stem cells and generated mice which are ..
  28. ncbi Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury
    S G Soriano
    Department of Anesthesia, Children s Hospital, Boston, MA 02115, USA
    Stroke 30:134-9. 1999
    Macrophage-1 antigen (Mac-1) (CD11b/CD18), a leukocyte beta2 integrin, facilitates neutrophil adhesion, transendothelial migration, phagocytosis, and respiratory burst, all of which may mediate reperfusion-induced injury to ischemic ..
  29. ncbi Utilization of CD11b knockout mice to characterize the role of complement receptor 3 (CR3, CD11b/CD18) in the growth of Mycobacterium tuberculosis in macrophages
    M D Melo
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Cell Immunol 205:13-23. 2000
    Using CD11b knockout mice as a source of macrophages (Mphi;), we show that complement receptor 3 (CR3) mediates approximately 40-50% of nonopsonic binding and 50-60% of serum-mediated binding of Mycobacterium tuberculosis to resident ..
  30. ncbi CD11b/CD18 acts in concert with CD14 and Toll-like receptor (TLR) 4 to elicit full lipopolysaccharide and taxol-inducible gene expression
    P Y Perera
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 166:574-81. 2001
    ..Recent reports indicate that three membrane-associated proteins, CD14, CD11b/CD18, and Toll-like receptor (TLR) 4, may serve as LPS recognition and/or signaling receptors in murine ..
  31. pmc Dectin-1 is a major beta-glucan receptor on macrophages
    Gordon D Brown
    Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    J Exp Med 196:407-12. 2002
    ..Furthermore, nonopsonic zymosan binding was unaffected by genetic CD11b deficiency or a blocking monoclonal antibody (mAb) against CR3, demonstrating that CR3 was not the beta-glucan ..
  32. ncbi Fcgamma-receptors induce Mac-1 (CD11b/CD18) mobilization and accumulation in the phagocytic cup for optimal phagocytosis
    Jenny Jongstra-Bilen
    Cell Biology Program, Hospital for Sick Children and the Department of Biochemistry, University of Toronto, Toronto, Ontario M5G 1X8, Canada
    J Biol Chem 278:45720-9. 2003
    Functional interactions between Fcgamma-receptors (FcgammaR) and the beta2 integrin Mac-1 (CD11b/CD18) have been described, but the molecular basis of this relationship remains unclear...
  33. ncbi An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells
    Gerard Eberl
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Nat Immunol 5:64-73. 2004
    ..This early LTi cell-mediated activation of lymph node and Peyer's patch mesenchyma forms the necessary platform for the subsequent development of mature lymphoid tissues...
  34. pmc Loss of LFA-1, but not Mac-1, protects MRL/MpJ-Fas(lpr) mice from autoimmune disease
    Christopher G Kevil
    Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, LA, USA
    Am J Pathol 165:609-16. 2004
    ..These studies identify LFA-1 as a key contributor in the pathogenesis of autoimmune disease in this model, and further suggest that therapeutic strategies targeting this adhesion molecule may be beneficial for the treatment of SLE...
  35. ncbi Manifestations of inflammatory arthritis are critically dependent on LFA-1
    Gerald M Watts
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 174:3668-75. 2005
    ..Blocking mAbs further revealed an ongoing requirement for LFA-1 I-domain adhesive function in disease perpetuation. These findings suggest that the LFA-1 I-domain forms an attractive target for treatment of human inflammatory arthritis...
  36. pmc A specific role of integrin Mac-1 in accelerated macrophage efflux to the lymphatics
    Chunzhang Cao
    Department of Physiology, University of Maryland School of Medicine, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
    Blood 106:3234-41. 2005
    ....
  37. ncbi Critical requirement of CD11b (Mac-1) on T cells and accessory cells for development of experimental autoimmune encephalomyelitis
    Daniel C Bullard
    Department of Genetics, University of Alabama at Birmingham, 35294, USA
    J Immunol 175:6327-33. 2005
    Mac-1 (CD18/CD11b) is a member of the beta2-integrin family of adhesion molecules and is implicated in the development of many inflammatory diseases...
  38. ncbi Non-PKC DAG/phorbol-ester receptor(s) inhibit complement receptor-3 and nPKC inhibit scavenger receptor-AI/II-mediated myelin phagocytosis but cPKC, PI3k, and PLCgamma activate myelin phagocytosis by both
    Goni Cohen
    Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School and the Eric Roland Center for Neurodegenerative Diseases, Jerusalem, Israel
    Glia 53:538-50. 2006
    Complement-receptor-3 (CR3/MAC-1), scavenger-receptor-AI/II (SRAI/II), and Fcgamma-receptor (FcgammaR) can mediate myelin phagocytosis in macrophages and microglia...
  39. ncbi Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling
    Jonathan C Kagan
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 125:943-55. 2006
    ..TIRAP then functions to facilitate MyD88 delivery to activated TLR4 to initiate signal transduction. These results establish that phosphoinositide-mediated adaptor recruitment initiates a specific signal-transduction pathway...
  40. pmc CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiation
    Driss Ehirchiou
    Center for Vascular and Inflammatory Diseases, Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Exp Med 204:1519-24. 2007
    ..We report that genetic inactivation of CD11b, which is a CD18 subfamily of integrin receptors that is highly expressed on APCs, abolishes orally induced ..
  41. ncbi Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein
    Wei Zhang
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
    Glia 55:1178-88. 2007
    ..These results have, for the first time, demonstrated that microglia are also critical in enhanced neurotoxicity induced by mutant alpha-synuclein...
  42. ncbi MAC1 mediates LPS-induced production of superoxide by microglia: the role of pattern recognition receptors in dopaminergic neurotoxicity
    Zhong Pei
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Glia 55:1362-73. 2007
    ..Using neuron-glia and microglia-enriched cultures from mice deficient in the MAC1 receptor (MAC1-/-), we demonstrate that lipopolysaccharide (LPS) treatment results in lower TNFalpha response, ..
  43. pmc Leukocyte integrin Mac-1 promotes acute cardiac allograft rejection
    Koichi Shimizu
    Donald W Reynolds Cardiovascular Clinical Research Center, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 117:1997-2008. 2008
    ..Although the leukocyte integrin Mac-1 (alpha(Mbeta2), CD11b/CD18) facilitates cell-cell interactions among leukocytes and interactions between leukocytes and endothelial ..
  44. doi Galectin-3/MAC-2, Ras and PI3K activate complement receptor-3 and scavenger receptor-AI/II mediated myelin phagocytosis in microglia
    Shlomo Rotshenker
    Department of Anatomy and Cell Biology, Hebrew University Faculty of Medicine, and The Eric Roland Center for Neurodegenerative Diseases, Jerusalem, Israel
    Glia 56:1607-13. 2008
    ..myelin through phosphatidylinositol-3-kinase (PI3K)-dependent phagocytosis mediated by complement receptor-3 (CR3/MAC-1) and scavenger receptor-AI/II (SRAI/II)...
  45. pmc Beta2-integrin-induced p38 MAPK activation is a key mediator in the CD14/TLR4/MD2-dependent uptake of lipopolysaccharide by hepatocytes
    Melanie J Scott
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 283:29433-46. 2008
    ..We find that essential components for LPS uptake are CD14, TLR4, MD2, and the beta2-integrin CD11b/CD18...
  46. pmc Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury
    Andres Hidalgo
    Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Nat Med 15:384-91. 2009
    ..These results indicate that endothelial selectins can influence neutrophil behavior beyond its canonical rolling step through delayed, organ-damaging, polarized activation...
  47. pmc The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling
    Kathleen Szczur
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Research Foundation, and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Blood 114:4527-37. 2009
    ..Interestingly, Cdc42 makes use of the integrin CD11b during this process. Cdc42 determines the redistribution of CD11b at the uropod...
  48. pmc Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection
    Jessica A Van Ziffle
    Immunology Program and the Department of Laboratory Medicine, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0451, USA
    Blood 114:4871-82. 2009
    ..These results indicate that loss of Syk kinase-mediated integrin signaling impairs leukocyte activation, leading to reduced host defense responses...
  49. doi Dissimilar and similar functional properties of complement receptor-3 in microglia and macrophages in combating yeast pathogens by phagocytosis
    Smadar Hadas
    Department of Medical Neurobiology, IMRIC, Hebrew University Hadassah Medical School and the Eric Roland Center for Neurodegenerative Diseases, Jerusalem, Israel
    Glia 58:823-30. 2010
    ..Complement receptor-3 (CR3) has initially been implicated in mediating the phagocytosis of both C3bi-op and non-opsonized (nop) zymosan by MO ..
  50. doi Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b
    Chaofeng Han
    National Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University, Shanghai, China
    Nat Immunol 11:734-42. 2010
    ..However, the interaction between integrin alpha(M) (CD11b), which has high expression in monocytes and macrophages, and Toll-like receptor (TLR)-triggered innate immunity ..
  51. pmc Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules
    Sachin Kumar
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Research Foundation, OH, USA
    Blood 120:3563-74. 2012
    ..In our previous report, we suggested that Rho GTPase Cdc42 controls neutrophil polarity through CD11b signaling at the uropod, albeit through an unknown mechanism...
  52. pmc Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b β2-integrin-dependent signaling
    Sarah J McMillan
    Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dundee, United Kingdom
    Blood 121:2084-94. 2013
    ..mice exhibited exaggerated neutrophil recruitment that was reversed by blockade of the β2 integrin, CD11b. Siglec-E suppressed CD11b "outside-in" signaling, because siglec-E-deficient neutrophils plated on the CD11b ..
  53. doi 5-Lipoxygenase plays a pivotal role in endothelial adhesion of monocytes via an increased expression of Mac-1
    Seung Jin Lee
    Department of Pharmacology, School of Medicine, Pusan National University, Yangsan, Gyeongnam, Korea
    Cardiovasc Res 99:724-33. 2013
    ....
  54. pmc A role for Mac-1 (CDIIb/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcgamma receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritis
    T Tang
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Exp Med 186:1853-63. 1997
    ..Since Mac-1 on PMNs is the principal ligand for ic3b, an absence of Mac-1 interaction with C3 probably contributed to the abrogation of proteinuria in Mac-1-null mice...
  55. ncbi Inactivation of CD11b in a mouse transgenic model protects against sepsis-induced lung PMN infiltration and vascular injury
    Xiao Pei Gao
    Department of Pharmacology, The University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    Physiol Genomics 21:230-42. 2005
    To inactivate chronically the beta2-integrin CD11b (Mac-1), we made a transgenic model in mice in which we expressed the CD11b antagonist polypeptide neutrophil inhibitory factor (NIF)...
  56. ncbi The role of Mac-1 (CD11b/CD18) in antigen-induced airway eosinophilia in mice
    S Kanwar
    Speros P Martel Laboratory of Leukocyte Biology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Respir Cell Mol Biol 25:170-7. 2001
    Mac-1 (CD11b/CD18) is an important adhesion molecule involved in the migration of leukocytes, cell signaling, and subsequent secretory responses. Its precise role in eosinophil recruitment and activation in vivo is not entirely clear...
  57. pmc Intraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascade
    Mia Phillipson
    Immunology Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary T2N 4N1, Alberta, Canada
    J Exp Med 203:2569-75. 2006
    The prevailing view is that the beta2-integrins Mac-1 (alphaMbeta2, CD11b/CD18) and LFA-1 (alphaLbeta2, CD11a/CD18) serve similar biological functions, namely adhesion, in the leukocyte recruitment cascade...
  58. pmc Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease
    Xiaoming Hu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Immunol 181:7194-204. 2008
    ..In this study we delineate the critical role of macrophage Ag complex-1 (MAC1), a member of the beta(2) integrin family, in mediating reactive microgliosis and promoting dopaminergic (DAergic) ..
  59. pmc Mapping of antigenic and functional epitopes on the alpha- and beta-subunits of two related mouse glycoproteins involved in cell interactions, LFA-1 and Mac-1
    F Sanchez-Madrid
    J Exp Med 158:586-602. 1983
    ..Therefore, sites of Mac-1 and LFA-1 involved in their respective adhesion-related functions, as well as distinctive structural features, have been localized to the alpha-subunits...
  60. ncbi Mac-1 (CD11b/CD18) and CD45 mediate the adhesion of hematopoietic progenitor cells to stromal cell elements via recognition of stromal heparan sulfate
    D R Coombe
    Sir William Dunn School of Pathology, University of Oxford, UK
    Blood 84:739-52. 1994
    ..The data suggest that heparan sulfate on the 3T3 cell surface is a ligand for both CD45 and Mac-1, but the two molecules recognize different heparan sulfate structural motifs...
  61. ncbi Impaired mast cell development and innate immunity in Mac-1 (CD11b/CD18, CR3)-deficient mice
    A R Rosenkranz
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 161:6463-7. 1998
    Mac-1 (CD11b/CD18, CR3), a beta2 integrin expressed on leukocytes, is important in leukocyte migration...
  62. ncbi Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration
    Z M Ding
    Speros P Martel Laboratory of Leukocyte Biology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    J Immunol 163:5029-38. 1999
    ..Neutrophil extravasation in response to TNF-alpha in LFA-1-deficient mice dramatically decreased, whereas neutrophil extravasation in Mac-1-deficient mice markedly increased...
  63. ncbi PU.1 is required for myeloid-derived but not lymphoid-derived dendritic cells
    A Guerriero
    Institute for Human Gene Therapy, University of Pennsylvania, Philadelphia, PA 19104 6140, USA
    Blood 95:879-85. 2000
    ..PU. 1(-/-)lymphoid DC were functionally equivalent to WT DC for stimulating T-cell proliferation in mixed lymphocyte reactions. These results demonstrate that PU.1 is required for the development of myeloid DC but not lymphoid DC...
  64. ncbi Control of leukocyte rolling velocity in TNF-alpha-induced inflammation by LFA-1 and Mac-1
    Jessica L Dunne
    Department of Biomedical Engineering and Cardiovascular Research Center, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    Blood 99:336-41. 2002
    ..Thus, both LFA-1 and Mac-1 contribute to slowing down rolling leukocytes, although LFA-1 is more important than Mac-1 in efficiently inducing firm adhesion...
  65. ncbi Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivo
    Junko Matsuzaki
    Division of Immunoregulation, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, 060 0815, Hokkaido, Sapporo, Japan
    Cell Immunol 224:98-105. 2003
    ..Thus, we initially demonstrated that anti-Gr-1 mAb might become a good tool to investigate a precise role for memory-type CD8(+) T cells in vivo...
  66. ncbi Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy
    Junichi Hirahashi
    Department of Pathology, Center for Excellence in Vascular Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 25:271-83. 2006
    ..These data suggest that Mac-1 engagement of complement activates tyrosine kinases to promote elastase-dependent blood vessel injury in vivo...
  67. pmc Expression, activation, and function of integrin alphaMbeta2 (Mac-1) on neutrophil-derived microparticles
    Elzbieta Pluskota
    Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic, OH 44195, USA
    Blood 112:2327-35. 2008
    ..The presence and activation state of a multifunctional leukocyte receptor, integrin alpha(M)beta(2) (CD11b/18), on MPs derived from human neutrophils (PMNs) were examined...
  68. doi Pathophysiological levels of soluble P-selectin mediate adhesion of leukocytes to the endothelium through Mac-1 activation
    Kevin J Woollard
    Baker IDI Heart and Diabetes Institute, 75 Commercial Rd, Melbourne, 3004, Australia
    Circ Res 103:1128-38. 2008
    ....
  69. pmc A partial genomic DNA clone for the alpha subunit of the mouse complement receptor type 3 and cellular adhesion molecule Mac-1
    L Sastre
    Proc Natl Acad Sci U S A 83:5644-8. 1986
    A genomic clone coding for the alpha subunit of the mouse complement receptor type 3 and the cellular adhesion molecule Mac-1 has been isolated directly from a genomic library using synthetic oligonucleotide probes based on the amino-..
  70. pmc Transfer of type II collagen-induced arthritis from DBA/1 to severe combined immunodeficiency mice can be prevented by blockade of Mac-1
    P C Taylor
    Kennedy Institute of Rheumatology, London, UK
    Immunology 88:315-21. 1996
    ..Our findings support the hypothesis that cells expressing Mac-1 play an important role in the induction and maintenance of joint damage in collagen-induced arthritis...
  71. ncbi Arthritis critically dependent on innate immune system players
    Hong Ji
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
    Immunity 16:157-68. 2002
    ..We suggest that autoimmune disease, even one that is organ specific, can occur when mobilization of an adaptive immune response results in runaway activation of the innate response...
  72. ncbi Mac-1 (CD11b/CD18) as accessory molecule for Fc alpha R (CD89) binding of IgA
    Annemiek B van Spriel
    Immunotherapy Laboratory, Department of Immunology, University Medical Center, Medarex Europe, and Genmab, Utrecht, The Netherlands
    J Immunol 169:3831-6. 2002
    ..Binding studies showed the secretory component, by itself, to interact with Mac-1-expressing PMN, but not with Mac-1(-/-) PMN. These data demonstrate an essential role for Mac-1 in establishing SIgA-FcalphaRI interactions...
  73. ncbi Leukocyte migration in adipose tissue of mice null for ICAM-1 and Mac-1 adhesion receptors
    Rebecca L Robker
    Section of Leukocyte Biology, Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1100 Bates Avenue, Houston, TX 77030, USA
    Obes Res 12:936-40. 2004
    ....
  74. pmc Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization
    Ingrid G Winkler
    Haematopoietic Stem Cell Laboratory, Mater Medical Research Institute, South Brisbane, Queensland 4101, Australia
    J Exp Med 201:1077-88. 2005
    ..These data suggest an unexpected role for serpina1 and serpina3 in regulating the bone marrow hematopoietic microenvironment as well as influencing the migratory behavior of hematopoietic precursors...
  75. ncbi The complex mechanism of antibody-mediated clearance of Bordetella from the lungs requires TLR4
    Girish S Kirimanjeswara
    Immunology Research Laboratories, Department of Biomedical Veterinary Sciences, Pennsylvania State University, University Park 16802, USA
    J Immunol 175:7504-11. 2005
    ..neutrophils that are necessary for Ab-mediated bacterial clearance via a mechanism that requires both FcgammaR and CR3. These data are consistent with a model in which TLR4-mediated inflammatory responses aid in the recruitment of ..
  76. ncbi Macrophages driven to a novel state of activation have anti-inflammatory properties in mice
    Beate G Brem-Exner
    Department of Surgery, University of Regensburg, Germany
    J Immunol 180:335-49. 2008
    ..IFNgamma-MdC express markers including F4/80, CD11b/c, CD86, and CD274; they are negative for CD4, CD8, Gr1, CD19, CD80, and CD207...
  77. pmc Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction
    Alessandro Fantin
    UCL Institute of Ophthalmology, University College London, London, United Kingdom
    Blood 116:829-40. 2010
    ..Our findings suggest that tissue macrophages are a target for antiangiogenic therapies, but that they could equally well be exploited to stimulate tissue vascularization in ischemic disease...
  78. doi CD11c-expressing cells reside in the juxtavascular parenchyma and extend processes into the glia limitans of the mouse nervous system
    Carolin Prodinger
    Institute of Clinical Neuroanatomy, Johann Wolfgang Goethe University, 60590 Frankfurt Main, Germany
    Acta Neuropathol 121:445-58. 2011
    ..Virtually all CD11c+ cells co-expressed ionized calcium-binding adaptor molecule 1 (IBA-1), CD11b, while detectable levels of major histocompatibility complex II (MHC-II) in non-diseased mice was restricted to ..
  79. doi Mycobacterial hypersensitivity pneumonitis requires TLR9-MyD88 in lung CD11b+ CD11c+ cells
    H Daito
    Dept of Pulmonary Medicine, Tohoku University Hospital, Aobaku, Sendai, Japan
    Eur Respir J 38:688-701. 2011
    ..Further investigation revealed that pulmonary exposure to M. avium HP strain increased the number of lung CD11b+ CD11c+ cells (dendritic cells) through TLR9 signalling...
  80. pmc IFN-γ regulates survival and function of tumor-induced CD11b+ Gr-1high myeloid derived suppressor cells by modulating the anti-apoptotic molecule Bcl2a1
    José Medina-Echeverz
    GI Malignancy Section, Thoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Eur J Immunol 44:2457-67. 2014
    ..Here, we describe how regulation of Bcl2a1 by cytokines controls the suppressor function of CD11b(+) Gr-1(high) granulocytic MDSCs...
  81. pmc The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation
    Sachin Kumar
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Research Foundation, Cincinnati, OH 45229 University of Cincinnati College of Medicine, Cincinnati OH 45229
    J Exp Med 211:1741-58. 2014
    ..The inhibitory action of Rap1b on PI3K signaling may be mediated by activation of phosphatase SHP-1. Thus, this study reveals an unexpected role for Rap1b as a key suppressor of neutrophil migration and lung inflammation...
  82. pmc Blockade of indoleamine 2,3-dioxygenase reduces mortality from peritonitis and sepsis in mice by regulating functions of CD11b+ peritoneal cells
    Masato Hoshi
    Faculty of Medical Science, Suzuka University of Medical Science, Suzuka, Japan Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Infect Immun 82:4487-95. 2014
    ..Ido expression in the peritoneal CD11b(+) cells and its metabolite l-kynurenine in the serum were increased after CLP...
  83. pmc Noninvasive imaging of immune responses
    Mohammad Rashidian
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142 Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142
    Proc Natl Acad Sci U S A 112:6146-51. 2015
    ..tumors often contain neutrophils, dendritic cells, and activated macrophages, which express class II MHC and CD11b products...
  84. pmc Mouse CD11b+Kupffer Cells Recruited from Bone Marrow Accelerate Liver Regeneration after Partial Hepatectomy
    Kiyoshi Nishiyama
    Department of Surgery, National Defense Medical College, Namiki 3 2, Tokorozawa, Saitama, Japan 359 8513
    PLoS ONE 10:e0136774. 2015
    ..resident radio-resistant CD68+cells with phagocytic and bactericidal activity, and recruited radio-sensitive CD11b+cells with cytokine-producing capacity...
  85. ncbi Mac-1, but not LFA-1, uses intercellular adhesion molecule-1 to mediate slow leukocyte rolling in TNF-alpha-induced inflammation
    Jessica L Dunne
    Department of Biomedical Engineering and Cardiovascular Research Center, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Immunol 171:6105-11. 2003
    ..However, blocking both Mac-1 and ICAM-1 had no greater effect than either blockade alone. We conclude that endothelial ICAM-1 is the main ligand responsible for slow leukocyte rolling mediated by Mac-1, but not LFA-1...
  86. pmc Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg
    David D Kim
    Department of Pharmacology, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Blood 112:1109-19. 2008
    ..Antibody blocking or gene ablation of the newly identified complement receptor CRIg, but not complement receptor 3 (CR3), rescued DAF/Crry-deficient platelets from complement-dependent elimination...
  87. pmc CD14-Mac-1 interactions in Bacillus anthracis spore internalization by macrophages
    Claudia Oliva
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 2170, USA
    Proc Natl Acad Sci U S A 106:13957-62. 2009
    ..Our results show that the binding and uptake of B. anthracis spores by phagocytic cells is a dynamic process and involves multiple receptors and signaling pathways...
  88. doi Selective down-regulation of neutrophil Mac-1 in endotoxemic hepatic microcirculation via IL-10
    Gustavo Batista Menezes
    Calvin, Phoebe, and Joan Snyder Institute for Infection, Immunity, and Inflammation, University of Calgary, Alberta, Canada
    J Immunol 183:7557-68. 2009
    ..This may be a mechanism to keep neutrophils in sinusoids for intravascular trapping...
  89. doi Complement receptor 3 (CD11b/CD18) is implicated in the elimination of β-amyloid peptides
    Nada Choucair-Jaafar
    UMR 7213, Universite de Strasbourg, CNRS, 74 route du Rhin, 67401 Illkirch, France
    Fundam Clin Pharmacol 25:115-22. 2011
    ..the professional phagocytes of the brain and express phagocytic receptors such as complement receptor 3 (CR3 or CD11b/CD18)...
  90. doi A systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine system
    Matthias Zielonka
    Max Planck Institute for Heart and Lung Research, Department of Pharmacology, Ludwigstr 43, 61231 Bad Nauheim, Germany
    Exp Cell Res 316:2477-86. 2010
    ..This work establishes Plexin-B2 and Sema4C as potential regulators of the vascular and endocrine system and provides an anatomical basis to understand the biological functions of this ligand-receptor pair...
  91. pmc Agglutination of Histoplasma capsulatum by IgG monoclonal antibodies against Hsp60 impacts macrophage effector functions
    Allan Jefferson Guimarães
    Department of Medicine Division of Infectious Diseases, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, USA
    Infect Immun 79:918-27. 2011
    ..Hence, the capacity of IgG MAbs to agglutinate H. capsulatum significantly impacted pathogenic mechanisms of H. capsulatum during macrophage infection, and the effect was dependent on the antibody subclass and antigen epitope...
  92. doi Expression of lymphatic endothelium-specific hyaluronan receptor LYVE-1 in the developing mouse kidney
    Hyun Wook Lee
    Department of Anatomy and MRC for Cell Death Disease Research Center, College of Medicine, The Catholic University of Korea, 505, Banpo dong, Seocho Ku, Seoul, 137 701, Korea
    Cell Tissue Res 343:429-44. 2011
    ..However, in the developing mouse kidney, LYVE-1 was also expressed transiently in F4/80(+)/CD11b(-) immature macrophages/dendritic cells and in the developing renal vein...
  93. pmc IL-33 expands suppressive CD11b+ Gr-1(int) and regulatory T cells, including ST2L+ Foxp3+ cells, and mediates regulatory T cell-dependent promotion of cardiac allograft survival
    Heth R Turnquist
    Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Immunol 187:4598-610. 2011
    ..IL-33 expands functional myeloid-derived suppressor cells, CD11b(+) cells that exhibit intermediate (int) levels of Gr-1 and potent T cell suppressive function...
  94. doi Urokinase-type plasminogen activator promotes paracellular transmigration of neutrophils via Mac-1, but independently of urokinase-type plasminogen activator receptor
    Christoph A Reichel
    Walter Brendel Centre of Experimental Medicine, Munich, Germany
    Circulation 124:1848-59. 2011
    ..Urokinase-type plasminogen activator (uPA) has recently been implicated in the pathogenesis of ischemia-reperfusion (I/R) injury. The underlying mechanisms remain largely unclear...
  95. pmc Binding of CD40L to Mac-1's I-domain involves the EQLKKSKTL motif and mediates leukocyte recruitment and atherosclerosis--but does not affect immunity and thrombosis in mice
    Dennis Wolf
    Atherogenesis Research Group, Department of Cardiology, University of Freiburg, Germany
    Circ Res 109:1269-79. 2011
    ..We recently reported that CD40L mediates atherogenesis independently of CD40 and proposed Mac-1 as an alternate receptor...
  96. pmc CD14 cooperates with complement receptor 3 to mediate MyD88-independent phagocytosis of Borrelia burgdorferi
    Kelly L Hawley
    Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01003, USA
    Proc Natl Acad Sci U S A 109:1228-32. 2012
    ..to different receptors on the surface of phagocytic cells, including the β(2) integrin, complement receptor 3 (CR3). However, whether these receptors mediate the phagocytosis of the spirochete remains unknown...
  97. pmc Activation of the classical complement pathway by Bacillus anthracis is the primary mechanism for spore phagocytosis and involves the spore surface protein BclA
    Chunfang Gu
    Institute of Biosciences and Technology, Texas A and M Health Science Center, Houston, TX 77030, USA
    J Immunol 188:4421-31. 2012
    ..These findings are likely to have significant implications on B. anthracis pathogenesis and microbial manipulation of complement...
  98. doi Integrin CD11b negatively regulates TLR9-triggered dendritic cell cross-priming by upregulating microRNA-146a
    Yi Bai
    National Key Laboratory of Medical Immunology, Institute of Immunology, Second Military Medical University, Shanghai 200433, China
    J Immunol 188:5293-302. 2012
    ..Our previous studies showed that β2 integrin CD11b could control TLR-triggered NK cell cytotoxicity and macrophage inflammatory responses...
  99. pmc NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche
    Chiung Ying Chang
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10065, USA
    Nature 495:98-102. 2013
    ..Our findings reveal how melanocyte and hair follicle stem cell behaviours maintain reliance upon cooperative factors within the niche, and how this can be uncoupled in injury, stress and disease states...
  100. ncbi Use of a photoactivatable taxol analogue to identify unique cellular targets in murine macrophages: identification of murine CD18 as a major taxol-binding protein and a role for Mac-1 in taxol-induced gene expression
    N Bhat
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 162:7335-42. 1999
    ..Since CD18 has been described as a participant in LPS-induced binding and signal transduction, these data support the hypothesis that the interaction of murine CD18 with Taxol is involved in its proinflammatory activity...
  101. ncbi Exploiting type 3 complement receptor for TNF-alpha suppression, immune evasion, and progressive pulmonary fungal infection
    T Tristan Brandhorst
    Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
    J Immunol 173:7444-53. 2004
    TNF-alpha is crucial in defense against intracellular microbes. Host immune cells use type 3 complement receptors (CR3) to regulate excess TNF-alpha production during physiological clearance of apoptotic cells...

Research Grants8

  1. Microglial Cell Activation by Thrombin in Stroke
    Jonathan Weinstein; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  2. NEUTROPHIL RECRUITMENT IN LPS-INDUCED AIRWAY DISEASE
    Jessica Moreland; Fiscal Year: 2004
    ....
  3. The Mechanism of IVIG Action in Pemphigus
    Zhi Liu; Fiscal Year: 2006
    ..The overall goal of this project is to study the mechanisms of WIG action in autoantibody-mediated diseases and develop novel therapies to replace current immunosuppressive treatments, which confer severe side effects. ..
  4. Role of CIC-3 channels in regulation of cell volume and shape in neutrophils
    Jessica Moreland; Fiscal Year: 2007
    ..The studies proposed will advance our fundamental knowledge of the function of neutrophils in the maintenance of normal immune system function. [unreadable] [unreadable] [unreadable]..
  5. Investigation of Nod2: Implications for Uveitis
    Holly Rosenzweig; Fiscal Year: 2008
    ..Together, these studies will provide valuable new information on how Nod2 is involved in autoimmunity and the pathogeneis of uveitis. ..
  6. Arbovirus Evasion of Type I Interferon Induction
    Mark Heise; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  7. Improved Vaccines for Rift Valley Fever Virus
    Mark T Heise; Fiscal Year: 2010
    ....
  8. TOGAVIRUS TROPISM FOR BONES, JOINTS, AND CNS
    Mark T Heise; Fiscal Year: 2010
    ....