Genomes and Genes
Gene Symbol: Itgam
Description: integrin alpha M
Alias: CD11b/CD18, CR3, CR3A, Cd11b, F730045J24Rik, Ly-40, MAC1, Mac-1, Mac-1a, integrin alpha-M, CD11 antigen-like family member B, CD11B (p170), CR-3 alpha chain, Mac-1 alpha, cell surface glycoprotein MAC-1 alpha subunit, cell surface glycoprotein MAC-1 subunit alpha, complement component receptor 3 alpha-a, complement receptor type 3, leukocyte adhesion receptor MO1, macrophage antigen alpha
Publications155 found, 100 shown here
- Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptorShirley Wakselman
Laboratoire de Biologie Cellulaire de la Synapse, Institut National de Santé et de Recherche Médicale, Unité 789, 75230 Paris Cedex 05, France
J Neurosci 28:8138-43. 2008..that, in the developing hippocampus, apoptotic neurons are contacted by microglia expressing both the integrin CD11b and the immunoreceptor DAP12...
- CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1Andreas Zirlik
Donald W Reynolds Center, Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Circulation 115:1571-80. 2007..The present study aimed to characterize the contribution of CD40 signaling to atherogenesis...
- The LFA-1 adhesion molecule is required for protective immunity during pulmonary Mycobacterium tuberculosis infectionShamik Ghosh
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 176:4914-22. 2006..To address this question, we infected knockout (KO) mice that have defective expression of CD11a, CD11b, CD18, CD62, CD103, or beta7...
- The integrin Mac-1 (CR3) mediates internalization and directs Bacillus anthracis spores into professional phagocytesClaudia R Oliva
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 2170, USA
Proc Natl Acad Sci U S A 105:1261-6. 2008..anthracis spores (WT spores). Conversely, CD11b(-/-) macrophages demonstrated a significant decrease in spore uptake when compared with macrophages from normal ..
- The calcineurin B subunit induces TNF-related apoptosis-inducing ligand (TRAIL) expression via CD11b-NF-κB pathway in RAW264.7 macrophagesZhenyi Su
Department of Biochemistry and Molecular Biology, Beijing Normal University, Beijing Key Laboratory, Beijing 100875, PR China
Biochem Biophys Res Commun 417:777-83. 2012..Here, we report that the calcineurin B subunit binds to CD11b on RAW264...
- Amino acid sequence of the murine Mac-1 alpha chain reveals homology with the integrin family and an additional domain related to von Willebrand factorR Pytela
Basel Institute for Immunology, Switzerland
EMBO J 7:1371-8. 1988..In two of these proteins, the homologous domain is likely to be involved in binding to collagen fibrils. Therefore, Mac-1 may also bind to collagen, which could play a role in the interaction of leukocytes with the subendothelial matrix...
- CD11b and intercellular adhesion molecule-1 are involved in pulmonary neutrophil recruitment in lipopolysaccharide-induced airway diseaseJessica G Moreland
Division of Critical Care, Department of Pediatrics, University of Iowa, Iowa City 52242, USA
Am J Respir Cell Mol Biol 27:474-80. 2002To better define the roles of CD11b, CD11a, and one of their endothelial cell receptors, intercellular adhesion molecule-1 (ICAM-1), in the lower respiratory tract inflammatory response to inhaled lipopolysaccharide (LPS), we evaluated ..
- The role of Mac-1 (CD11b/CD18) in osteoclast differentiation induced by receptor activator of nuclear factor-kappaB ligandHidetaka Hayashi
Department of Cellular Physiological Chemistry, Graduate School, Tokyo Medical and Dental University, 1 5 45, Yushima, Tokyo 113 8549, Japan
FEBS Lett 582:3243-8. 2008Multinuclear osteoclasts are derived from CD11b-positive mononuclear cells in bone marrow and in circulation. FACS sorting experiments showed impaired osteoclastogenesis in RAW264.7 cells with low CD11b expression...
- Modulating the expression of IFN regulatory factor 8 alters the protumorigenic behavior of CD11b+Gr-1+ myeloid cellsTrina J Stewart
Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 183:117-28. 2009b>CD11b(+)Gr-1(+)-expressing cells, termed myeloid-derived suppressor cells, can mediate immunosuppression and tumor progression. However, the intrinsic molecular events that drive their protumorigenic behavior remain to be elucidated...
- Inhibition of phagocytosis in HIV-1-infected macrophages relies on Nef-dependent alteration of focal delivery of recycling compartmentsJulie Mazzolini
Institut Cochin, Universite Paris Descartes, Centre National de la Recherche Scientifique Unite Mixte de Recherche 8104, Paris, France
Blood 115:4226-36. 2010..We conclude that HIV-1 impairs optimal phagosome formation through Nef-dependent perturbation of the endosomal remodeling relying on AP1. We therefore identified a mechanism of macrophage function down-regulation in infected cells...
- LFA-1 and Mac-1 define characteristically different intralumenal crawling and emigration patterns for monocytes and neutrophils in situRonen Sumagin
Department of Pharmacology and Physiology, University of Rochester, Rochester, NY 14642, USA
J Immunol 185:7057-66. 2010..Using function-blocking Abs, we show that these different crawling patterns were due to CD11a/CD18 (LFA-1)- versus CD11b/CD18 (Mac-1)-mediated crawling...
- Mac-1: a macrophage differentiation antigen identified by monoclonal antibodyT Springer
Eur J Immunol 9:301-6. 1979
- PU. 1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiationM C Olson
Howard Hughes Medical Institute, University of Chicago, Illinois 60637, USA
Immunity 3:703-14. 1995..1-/- ES cells. However, the expression of genes associated with terminal myeloid differentiation (CD11b, CD64, and M-CSFR) is eliminated in differentiated PU.1-/- ES cells...
- Decreased neointimal formation in Mac-1(-/-) mice reveals a role for inflammation in vascular repair after angioplastyD I Simon
Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 105:293-300. 2000..markers of leukocyte activation - in particular, increased expression of the beta2-integrin Mac-1 (alphaMbeta2, or CD11b/CD18), which is responsible for firm leukocyte adhesion to platelets and fibrinogen on denuded vessels - predict ..
- Mac-1 (CD11b/CD18) is essential for Fc receptor-mediated neutrophil cytotoxicity and immunologic synapse formationA B van Spriel
Immunotherapy Laboratory and Medarex Europe, University Medical Center Utrecht, The Netherlands
Blood 97:2478-86. 2001..Mac-1 (complement receptor type 3, CD11b/CD18) has previously been implicated in receptor cooperation with Fc receptors (FcRs)...
- Control of myeloid-specific integrin alpha Mbeta 2 (CD11b/CD18) expression by cytokines is regulated by Stat3-dependent activation of PU.1Athanasia D Panopoulos
Department of Immunology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Biol Chem 277:19001-7. 2002..migration capabilities, we studied inducible expression of the myeloid-specific marker, integrin alpha(M)beta(2) (CD11b/CD18, Mac-1), in the myeloid cell line, 32D...
- Modulation of Mac-1 (CD11b/CD18)-mediated adhesion by the leukocyte-specific protein 1 is key to its role in neutrophil polarization and chemotaxisChunjie Wang
Cellular and Molecular Biology Division, Toronto Western Research Institute, Canada
J Immunol 169:415-23. 2002..These results suggest that LSP1 regulates the function of Mac-1 (CD11b/CD18), which binds only to fibrinogen and ICAM-1 among the substrates we tested...
- Contributions of LFA-1 and Mac-1 to brain injury and microvascular dysfunction induced by transient middle cerebral artery occlusionThiruma V Arumugam
Dept of Molecular and Cellular Physiology, Louisiana State Univ Health Sciences Center, 1500 Kings Highway, Shreveport, LA 71130, USA
Am J Physiol Heart Circ Physiol 287:H2555-60. 2004..These findings indicate that both alpha-subunits of the beta2-integrins contribute to the brain injury and blood cell-vessel wall interactions that are associated with transient focal cerebral ischemia...
- Distinct roles of Mac-1 and its counter-receptors in neonatal obstructive nephropathyB Lange-Sperandio
Department of Pediatrics, University of Heidelberg, Heidelberg, Germany
Kidney Int 69:81-8. 2006..ICAM-1 and its new ligands RAGE and JAM-C are sequentially activated in UUO. Blocking of Mac-1 and its ligands may confer synergistic renoprotective effects in neonatal obstructive nephropathy...
- CD11b+/Gr-1+ myeloid suppressor cells cause T cell dysfunction after traumatic stressValeriya P Makarenkova
Department of Surgery, University of Pittsburgh Medical Center, PA 15213, USA
J Immunol 176:2085-94. 2006..We describe that myeloid suppressor cells expressing CD11b(+)/Gr-1(+) markers invade the spleen after traumatic stress and suppress T cell function through the production of ..
- Endocytic receptor LRP together with tPA and PAI-1 coordinates Mac-1-dependent macrophage migrationChunzhang Cao
Department of Physiology and Surgery, Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, 21201, USA
EMBO J 25:1860-70. 2006....
- alpha-Chain phosphorylation of the human leukocyte CD11b/CD18 (Mac-1) integrin is pivotal for integrin activation to bind ICAMs and leukocyte extravasationSusanna C Fagerholm
Division of Biochemistry, Faculty of Biosciences, PB56 Viikinkaari 5, 00014 University of Helsinki, Helsinki, Finland
Blood 108:3379-86. 2006The promiscuous CD11b/CD18 (Mac-1) integrin has important roles in regulating many immunologic functions such as leukocyte adhesion and emigration from the bloodstream via interactions with the endothelial ligands ICAM-1 and ICAM-2, iC3b-..
- Lymphocyte function-associated antigen-1-dependent inhibition of corneal wound healingZhijie Li
Section of Leukocyte Biology, Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030 2600, USA
Am J Pathol 169:1590-600. 2006..We investigated the contributions of lymphocyte function-associated antigen (LFA)-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) by analyzing wound closure in mice with targeted deletions of CD11a (CD11a-/-) or CD11b (CD11b-/-)...
- CD8+ dendritic cells use LFA-1 to capture MHC-peptide complexes from exosomes in vivoElodie Segura
Centre de Recherche, Institut Curie, Paris, France
J Immunol 179:1489-96. 2007..We propose a new role for LFA-1 on DCs, as a receptor for exosomes to favor Ag transfer between DCs in vivo...
- Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitmentG One Ahn
Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 107:8363-8. 2010..We have previously reported that bone marrow-derived CD11b(+) myeloid cells are recruited to tumors grown in irradiated tissues, thereby restoring the vasculature and tumor ..
- A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammationA Coxon
Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts, USA
Immunity 5:653-66. 1996In mice selectively deficient in CD11b/CD18, a beta 2 integrin, chemoattractant-induced leukocyte adhesion to microvascular endothelium in vivo was reduced...
- LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient miceH Lu
Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
J Clin Invest 99:1340-50. 1997To better define the specific function of Mac-1 (CD11b) versus LFA-1 (CD11a) and the other CD11 integrins in vivo, we have disrupted murine CD11b by targeted homologous recombination in embryonic stem cells and generated mice which are ..
- Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injuryS G Soriano
Department of Anesthesia, Children s Hospital, Boston, MA 02115, USA
Stroke 30:134-9. 1999Macrophage-1 antigen (Mac-1) (CD11b/CD18), a leukocyte beta2 integrin, facilitates neutrophil adhesion, transendothelial migration, phagocytosis, and respiratory burst, all of which may mediate reperfusion-induced injury to ischemic ..
- Utilization of CD11b knockout mice to characterize the role of complement receptor 3 (CR3, CD11b/CD18) in the growth of Mycobacterium tuberculosis in macrophagesM D Melo
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Cell Immunol 205:13-23. 2000Using CD11b knockout mice as a source of macrophages (Mphi;), we show that complement receptor 3 (CR3) mediates approximately 40-50% of nonopsonic binding and 50-60% of serum-mediated binding of Mycobacterium tuberculosis to resident ..
- CD11b/CD18 acts in concert with CD14 and Toll-like receptor (TLR) 4 to elicit full lipopolysaccharide and taxol-inducible gene expressionP Y Perera
Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
J Immunol 166:574-81. 2001..Recent reports indicate that three membrane-associated proteins, CD14, CD11b/CD18, and Toll-like receptor (TLR) 4, may serve as LPS recognition and/or signaling receptors in murine ..
- Dectin-1 is a major beta-glucan receptor on macrophagesGordon D Brown
Sir William Dunn School of Pathology, University of Oxford, United Kingdom
J Exp Med 196:407-12. 2002..Furthermore, nonopsonic zymosan binding was unaffected by genetic CD11b deficiency or a blocking monoclonal antibody (mAb) against CR3, demonstrating that CR3 was not the beta-glucan ..
- Fcgamma-receptors induce Mac-1 (CD11b/CD18) mobilization and accumulation in the phagocytic cup for optimal phagocytosisJenny Jongstra-Bilen
Cell Biology Program, Hospital for Sick Children and the Department of Biochemistry, University of Toronto, Toronto, Ontario M5G 1X8, Canada
J Biol Chem 278:45720-9. 2003Functional interactions between Fcgamma-receptors (FcgammaR) and the beta2 integrin Mac-1 (CD11b/CD18) have been described, but the molecular basis of this relationship remains unclear...
- An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cellsGerard Eberl
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
Nat Immunol 5:64-73. 2004..This early LTi cell-mediated activation of lymph node and Peyer's patch mesenchyma forms the necessary platform for the subsequent development of mature lymphoid tissues...
- Loss of LFA-1, but not Mac-1, protects MRL/MpJ-Fas(lpr) mice from autoimmune diseaseChristopher G Kevil
Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, LA, USA
Am J Pathol 165:609-16. 2004..These studies identify LFA-1 as a key contributor in the pathogenesis of autoimmune disease in this model, and further suggest that therapeutic strategies targeting this adhesion molecule may be beneficial for the treatment of SLE...
- Manifestations of inflammatory arthritis are critically dependent on LFA-1Gerald M Watts
Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 174:3668-75. 2005..Blocking mAbs further revealed an ongoing requirement for LFA-1 I-domain adhesive function in disease perpetuation. These findings suggest that the LFA-1 I-domain forms an attractive target for treatment of human inflammatory arthritis...
- A specific role of integrin Mac-1 in accelerated macrophage efflux to the lymphaticsChunzhang Cao
Department of Physiology, University of Maryland School of Medicine, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
Blood 106:3234-41. 2005....
- Critical requirement of CD11b (Mac-1) on T cells and accessory cells for development of experimental autoimmune encephalomyelitisDaniel C Bullard
Department of Genetics, University of Alabama at Birmingham, 35294, USA
J Immunol 175:6327-33. 2005Mac-1 (CD18/CD11b) is a member of the beta2-integrin family of adhesion molecules and is implicated in the development of many inflammatory diseases...
- Non-PKC DAG/phorbol-ester receptor(s) inhibit complement receptor-3 and nPKC inhibit scavenger receptor-AI/II-mediated myelin phagocytosis but cPKC, PI3k, and PLCgamma activate myelin phagocytosis by bothGoni Cohen
Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School and the Eric Roland Center for Neurodegenerative Diseases, Jerusalem, Israel
Glia 53:538-50. 2006Complement-receptor-3 (CR3/MAC-1), scavenger-receptor-AI/II (SRAI/II), and Fcgamma-receptor (FcgammaR) can mediate myelin phagocytosis in macrophages and microglia...
- Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signalingJonathan C Kagan
Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
Cell 125:943-55. 2006..TIRAP then functions to facilitate MyD88 delivery to activated TLR4 to initiate signal transduction. These results establish that phosphoinositide-mediated adaptor recruitment initiates a specific signal-transduction pathway...
- CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiationDriss Ehirchiou
Center for Vascular and Inflammatory Diseases, Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Exp Med 204:1519-24. 2007..We report that genetic inactivation of CD11b, which is a CD18 subfamily of integrin receptors that is highly expressed on APCs, abolishes orally induced ..
- Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synucleinWei Zhang
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina, USA
Glia 55:1178-88. 2007..These results have, for the first time, demonstrated that microglia are also critical in enhanced neurotoxicity induced by mutant alpha-synuclein...
- MAC1 mediates LPS-induced production of superoxide by microglia: the role of pattern recognition receptors in dopaminergic neurotoxicityZhong Pei
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Glia 55:1362-73. 2007..Using neuron-glia and microglia-enriched cultures from mice deficient in the MAC1 receptor (MAC1-/-), we demonstrate that lipopolysaccharide (LPS) treatment results in lower TNFalpha response, ..
- Leukocyte integrin Mac-1 promotes acute cardiac allograft rejectionKoichi Shimizu
Donald W Reynolds Cardiovascular Clinical Research Center, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
Circulation 117:1997-2008. 2008..Although the leukocyte integrin Mac-1 (alpha(Mbeta2), CD11b/CD18) facilitates cell-cell interactions among leukocytes and interactions between leukocytes and endothelial ..
- Galectin-3/MAC-2, Ras and PI3K activate complement receptor-3 and scavenger receptor-AI/II mediated myelin phagocytosis in microgliaShlomo Rotshenker
Department of Anatomy and Cell Biology, Hebrew University Faculty of Medicine, and The Eric Roland Center for Neurodegenerative Diseases, Jerusalem, Israel
Glia 56:1607-13. 2008..myelin through phosphatidylinositol-3-kinase (PI3K)-dependent phagocytosis mediated by complement receptor-3 (CR3/MAC-1) and scavenger receptor-AI/II (SRAI/II)...
- Beta2-integrin-induced p38 MAPK activation is a key mediator in the CD14/TLR4/MD2-dependent uptake of lipopolysaccharide by hepatocytesMelanie J Scott
Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Biol Chem 283:29433-46. 2008..We find that essential components for LPS uptake are CD14, TLR4, MD2, and the beta2-integrin CD11b/CD18...
- Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injuryAndres Hidalgo
Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
Nat Med 15:384-91. 2009..These results indicate that endothelial selectins can influence neutrophil behavior beyond its canonical rolling step through delayed, organ-damaging, polarized activation...
- The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signalingKathleen Szczur
Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Research Foundation, and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
Blood 114:4527-37. 2009..Interestingly, Cdc42 makes use of the integrin CD11b during this process. Cdc42 determines the redistribution of CD11b at the uropod...
- Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infectionJessica A Van Ziffle
Immunology Program and the Department of Laboratory Medicine, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0451, USA
Blood 114:4871-82. 2009..These results indicate that loss of Syk kinase-mediated integrin signaling impairs leukocyte activation, leading to reduced host defense responses...
- Dissimilar and similar functional properties of complement receptor-3 in microglia and macrophages in combating yeast pathogens by phagocytosisSmadar Hadas
Department of Medical Neurobiology, IMRIC, Hebrew University Hadassah Medical School and the Eric Roland Center for Neurodegenerative Diseases, Jerusalem, Israel
Glia 58:823-30. 2010..Complement receptor-3 (CR3) has initially been implicated in mediating the phagocytosis of both C3bi-op and non-opsonized (nop) zymosan by MO ..
- Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-bChaofeng Han
National Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University, Shanghai, China
Nat Immunol 11:734-42. 2010..However, the interaction between integrin alpha(M) (CD11b), which has high expression in monocytes and macrophages, and Toll-like receptor (TLR)-triggered innate immunity ..
- Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubulesSachin Kumar
Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Research Foundation, OH, USA
Blood 120:3563-74. 2012..In our previous report, we suggested that Rho GTPase Cdc42 controls neutrophil polarity through CD11b signaling at the uropod, albeit through an unknown mechanism...
- Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b β2-integrin-dependent signalingSarah J McMillan
Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dundee, United Kingdom
Blood 121:2084-94. 2013..mice exhibited exaggerated neutrophil recruitment that was reversed by blockade of the β2 integrin, CD11b. Siglec-E suppressed CD11b "outside-in" signaling, because siglec-E-deficient neutrophils plated on the CD11b ..
- 5-Lipoxygenase plays a pivotal role in endothelial adhesion of monocytes via an increased expression of Mac-1Seung Jin Lee
Department of Pharmacology, School of Medicine, Pusan National University, Yangsan, Gyeongnam, Korea
Cardiovasc Res 99:724-33. 2013....
- A role for Mac-1 (CDIIb/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcgamma receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritisT Tang
Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Exp Med 186:1853-63. 1997..Since Mac-1 on PMNs is the principal ligand for ic3b, an absence of Mac-1 interaction with C3 probably contributed to the abrogation of proteinuria in Mac-1-null mice...
- Inactivation of CD11b in a mouse transgenic model protects against sepsis-induced lung PMN infiltration and vascular injuryXiao Pei Gao
Department of Pharmacology, The University of Illinois College of Medicine, Chicago, Illinois 60612, USA
Physiol Genomics 21:230-42. 2005To inactivate chronically the beta2-integrin CD11b (Mac-1), we made a transgenic model in mice in which we expressed the CD11b antagonist polypeptide neutrophil inhibitory factor (NIF)...
- The role of Mac-1 (CD11b/CD18) in antigen-induced airway eosinophilia in miceS Kanwar
Speros P Martel Laboratory of Leukocyte Biology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
Am J Respir Cell Mol Biol 25:170-7. 2001Mac-1 (CD11b/CD18) is an important adhesion molecule involved in the migration of leukocytes, cell signaling, and subsequent secretory responses. Its precise role in eosinophil recruitment and activation in vivo is not entirely clear...
- Intraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascadeMia Phillipson
Immunology Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary T2N 4N1, Alberta, Canada
J Exp Med 203:2569-75. 2006The prevailing view is that the beta2-integrins Mac-1 (alphaMbeta2, CD11b/CD18) and LFA-1 (alphaLbeta2, CD11a/CD18) serve similar biological functions, namely adhesion, in the leukocyte recruitment cascade...
- Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's diseaseXiaoming Hu
Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
J Immunol 181:7194-204. 2008..In this study we delineate the critical role of macrophage Ag complex-1 (MAC1), a member of the beta(2) integrin family, in mediating reactive microgliosis and promoting dopaminergic (DAergic) ..
- Mapping of antigenic and functional epitopes on the alpha- and beta-subunits of two related mouse glycoproteins involved in cell interactions, LFA-1 and Mac-1F Sanchez-Madrid
J Exp Med 158:586-602. 1983..Therefore, sites of Mac-1 and LFA-1 involved in their respective adhesion-related functions, as well as distinctive structural features, have been localized to the alpha-subunits...
- Mac-1 (CD11b/CD18) and CD45 mediate the adhesion of hematopoietic progenitor cells to stromal cell elements via recognition of stromal heparan sulfateD R Coombe
Sir William Dunn School of Pathology, University of Oxford, UK
Blood 84:739-52. 1994..The data suggest that heparan sulfate on the 3T3 cell surface is a ligand for both CD45 and Mac-1, but the two molecules recognize different heparan sulfate structural motifs...
- Impaired mast cell development and innate immunity in Mac-1 (CD11b/CD18, CR3)-deficient miceA R Rosenkranz
Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
J Immunol 161:6463-7. 1998Mac-1 (CD11b/CD18, CR3), a beta2 integrin expressed on leukocytes, is important in leukocyte migration...
- Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migrationZ M Ding
Speros P Martel Laboratory of Leukocyte Biology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
J Immunol 163:5029-38. 1999..Neutrophil extravasation in response to TNF-alpha in LFA-1-deficient mice dramatically decreased, whereas neutrophil extravasation in Mac-1-deficient mice markedly increased...
- PU.1 is required for myeloid-derived but not lymphoid-derived dendritic cellsA Guerriero
Institute for Human Gene Therapy, University of Pennsylvania, Philadelphia, PA 19104 6140, USA
Blood 95:879-85. 2000..PU. 1(-/-)lymphoid DC were functionally equivalent to WT DC for stimulating T-cell proliferation in mixed lymphocyte reactions. These results demonstrate that PU.1 is required for the development of myeloid DC but not lymphoid DC...
- Control of leukocyte rolling velocity in TNF-alpha-induced inflammation by LFA-1 and Mac-1Jessica L Dunne
Department of Biomedical Engineering and Cardiovascular Research Center, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
Blood 99:336-41. 2002..Thus, both LFA-1 and Mac-1 contribute to slowing down rolling leukocytes, although LFA-1 is more important than Mac-1 in efficiently inducing firm adhesion...
- Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivoJunko Matsuzaki
Division of Immunoregulation, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, 060 0815, Hokkaido, Sapporo, Japan
Cell Immunol 224:98-105. 2003..Thus, we initially demonstrated that anti-Gr-1 mAb might become a good tool to investigate a precise role for memory-type CD8(+) T cells in vivo...
- Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathyJunichi Hirahashi
Department of Pathology, Center for Excellence in Vascular Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Immunity 25:271-83. 2006..These data suggest that Mac-1 engagement of complement activates tyrosine kinases to promote elastase-dependent blood vessel injury in vivo...
- Expression, activation, and function of integrin alphaMbeta2 (Mac-1) on neutrophil-derived microparticlesElzbieta Pluskota
Joseph J Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic, OH 44195, USA
Blood 112:2327-35. 2008..The presence and activation state of a multifunctional leukocyte receptor, integrin alpha(M)beta(2) (CD11b/18), on MPs derived from human neutrophils (PMNs) were examined...
- Pathophysiological levels of soluble P-selectin mediate adhesion of leukocytes to the endothelium through Mac-1 activationKevin J Woollard
Baker IDI Heart and Diabetes Institute, 75 Commercial Rd, Melbourne, 3004, Australia
Circ Res 103:1128-38. 2008....
- A partial genomic DNA clone for the alpha subunit of the mouse complement receptor type 3 and cellular adhesion molecule Mac-1L Sastre
Proc Natl Acad Sci U S A 83:5644-8. 1986A genomic clone coding for the alpha subunit of the mouse complement receptor type 3 and the cellular adhesion molecule Mac-1 has been isolated directly from a genomic library using synthetic oligonucleotide probes based on the amino-..
- Transfer of type II collagen-induced arthritis from DBA/1 to severe combined immunodeficiency mice can be prevented by blockade of Mac-1P C Taylor
Kennedy Institute of Rheumatology, London, UK
Immunology 88:315-21. 1996..Our findings support the hypothesis that cells expressing Mac-1 play an important role in the induction and maintenance of joint damage in collagen-induced arthritis...
- Arthritis critically dependent on innate immune system playersHong Ji
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Boston, MA 02215, USA
Immunity 16:157-68. 2002..We suggest that autoimmune disease, even one that is organ specific, can occur when mobilization of an adaptive immune response results in runaway activation of the innate response...
- Mac-1 (CD11b/CD18) as accessory molecule for Fc alpha R (CD89) binding of IgAAnnemiek B van Spriel
Immunotherapy Laboratory, Department of Immunology, University Medical Center, Medarex Europe, and Genmab, Utrecht, The Netherlands
J Immunol 169:3831-6. 2002..Binding studies showed the secretory component, by itself, to interact with Mac-1-expressing PMN, but not with Mac-1(-/-) PMN. These data demonstrate an essential role for Mac-1 in establishing SIgA-FcalphaRI interactions...
- Leukocyte migration in adipose tissue of mice null for ICAM-1 and Mac-1 adhesion receptorsRebecca L Robker
Section of Leukocyte Biology, Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1100 Bates Avenue, Houston, TX 77030, USA
Obes Res 12:936-40. 2004....
- Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilizationIngrid G Winkler
Haematopoietic Stem Cell Laboratory, Mater Medical Research Institute, South Brisbane, Queensland 4101, Australia
J Exp Med 201:1077-88. 2005..These data suggest an unexpected role for serpina1 and serpina3 in regulating the bone marrow hematopoietic microenvironment as well as influencing the migratory behavior of hematopoietic precursors...
- The complex mechanism of antibody-mediated clearance of Bordetella from the lungs requires TLR4Girish S Kirimanjeswara
Immunology Research Laboratories, Department of Biomedical Veterinary Sciences, Pennsylvania State University, University Park 16802, USA
J Immunol 175:7504-11. 2005..neutrophils that are necessary for Ab-mediated bacterial clearance via a mechanism that requires both FcgammaR and CR3. These data are consistent with a model in which TLR4-mediated inflammatory responses aid in the recruitment of ..
- Macrophages driven to a novel state of activation have anti-inflammatory properties in miceBeate G Brem-Exner
Department of Surgery, University of Regensburg, Germany
J Immunol 180:335-49. 2008..IFNgamma-MdC express markers including F4/80, CD11b/c, CD86, and CD274; they are negative for CD4, CD8, Gr1, CD19, CD80, and CD207...
- Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell inductionAlessandro Fantin
UCL Institute of Ophthalmology, University College London, London, United Kingdom
Blood 116:829-40. 2010..Our findings suggest that tissue macrophages are a target for antiangiogenic therapies, but that they could equally well be exploited to stimulate tissue vascularization in ischemic disease...
- CD11c-expressing cells reside in the juxtavascular parenchyma and extend processes into the glia limitans of the mouse nervous systemCarolin Prodinger
Institute of Clinical Neuroanatomy, Johann Wolfgang Goethe University, 60590 Frankfurt Main, Germany
Acta Neuropathol 121:445-58. 2011..Virtually all CD11c+ cells co-expressed ionized calcium-binding adaptor molecule 1 (IBA-1), CD11b, while detectable levels of major histocompatibility complex II (MHC-II) in non-diseased mice was restricted to ..
- Mycobacterial hypersensitivity pneumonitis requires TLR9-MyD88 in lung CD11b+ CD11c+ cellsH Daito
Dept of Pulmonary Medicine, Tohoku University Hospital, Aobaku, Sendai, Japan
Eur Respir J 38:688-701. 2011..Further investigation revealed that pulmonary exposure to M. avium HP strain increased the number of lung CD11b+ CD11c+ cells (dendritic cells) through TLR9 signalling...
- IFN-γ regulates survival and function of tumor-induced CD11b+ Gr-1high myeloid derived suppressor cells by modulating the anti-apoptotic molecule Bcl2a1José Medina-Echeverz
GI Malignancy Section, Thoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Eur J Immunol 44:2457-67. 2014..Here, we describe how regulation of Bcl2a1 by cytokines controls the suppressor function of CD11b(+) Gr-1(high) granulocytic MDSCs...
- The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activationSachin Kumar
Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Research Foundation, Cincinnati, OH 45229 University of Cincinnati College of Medicine, Cincinnati OH 45229
J Exp Med 211:1741-58. 2014..The inhibitory action of Rap1b on PI3K signaling may be mediated by activation of phosphatase SHP-1. Thus, this study reveals an unexpected role for Rap1b as a key suppressor of neutrophil migration and lung inflammation...
- Blockade of indoleamine 2,3-dioxygenase reduces mortality from peritonitis and sepsis in mice by regulating functions of CD11b+ peritoneal cellsMasato Hoshi
Faculty of Medical Science, Suzuka University of Medical Science, Suzuka, Japan Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
Infect Immun 82:4487-95. 2014..Ido expression in the peritoneal CD11b(+) cells and its metabolite l-kynurenine in the serum were increased after CLP...
- Noninvasive imaging of immune responsesMohammad Rashidian
Whitehead Institute for Biomedical Research, Cambridge, MA 02142 Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142
Proc Natl Acad Sci U S A 112:6146-51. 2015..tumors often contain neutrophils, dendritic cells, and activated macrophages, which express class II MHC and CD11b products...
- Mouse CD11b+Kupffer Cells Recruited from Bone Marrow Accelerate Liver Regeneration after Partial HepatectomyKiyoshi Nishiyama
Department of Surgery, National Defense Medical College, Namiki 3 2, Tokorozawa, Saitama, Japan 359 8513
PLoS ONE 10:e0136774. 2015..resident radio-resistant CD68+cells with phagocytic and bactericidal activity, and recruited radio-sensitive CD11b+cells with cytokine-producing capacity...
- Mac-1, but not LFA-1, uses intercellular adhesion molecule-1 to mediate slow leukocyte rolling in TNF-alpha-induced inflammationJessica L Dunne
Department of Biomedical Engineering and Cardiovascular Research Center, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
J Immunol 171:6105-11. 2003..However, blocking both Mac-1 and ICAM-1 had no greater effect than either blockade alone. We conclude that endothelial ICAM-1 is the main ligand responsible for slow leukocyte rolling mediated by Mac-1, but not LFA-1...
- Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIgDavid D Kim
Department of Pharmacology, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Blood 112:1109-19. 2008..Antibody blocking or gene ablation of the newly identified complement receptor CRIg, but not complement receptor 3 (CR3), rescued DAF/Crry-deficient platelets from complement-dependent elimination...
- CD14-Mac-1 interactions in Bacillus anthracis spore internalization by macrophagesClaudia Oliva
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 2170, USA
Proc Natl Acad Sci U S A 106:13957-62. 2009..Our results show that the binding and uptake of B. anthracis spores by phagocytic cells is a dynamic process and involves multiple receptors and signaling pathways...
- Selective down-regulation of neutrophil Mac-1 in endotoxemic hepatic microcirculation via IL-10Gustavo Batista Menezes
Calvin, Phoebe, and Joan Snyder Institute for Infection, Immunity, and Inflammation, University of Calgary, Alberta, Canada
J Immunol 183:7557-68. 2009..This may be a mechanism to keep neutrophils in sinusoids for intravascular trapping...
- Complement receptor 3 (CD11b/CD18) is implicated in the elimination of β-amyloid peptidesNada Choucair-Jaafar
UMR 7213, Universite de Strasbourg, CNRS, 74 route du Rhin, 67401 Illkirch, France
Fundam Clin Pharmacol 25:115-22. 2011..the professional phagocytes of the brain and express phagocytic receptors such as complement receptor 3 (CR3 or CD11b/CD18)...
- A systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine systemMatthias Zielonka
Max Planck Institute for Heart and Lung Research, Department of Pharmacology, Ludwigstr 43, 61231 Bad Nauheim, Germany
Exp Cell Res 316:2477-86. 2010..This work establishes Plexin-B2 and Sema4C as potential regulators of the vascular and endocrine system and provides an anatomical basis to understand the biological functions of this ligand-receptor pair...
- Agglutination of Histoplasma capsulatum by IgG monoclonal antibodies against Hsp60 impacts macrophage effector functionsAllan Jefferson Guimarães
Department of Medicine Division of Infectious Diseases, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, USA
Infect Immun 79:918-27. 2011..Hence, the capacity of IgG MAbs to agglutinate H. capsulatum significantly impacted pathogenic mechanisms of H. capsulatum during macrophage infection, and the effect was dependent on the antibody subclass and antigen epitope...
- Expression of lymphatic endothelium-specific hyaluronan receptor LYVE-1 in the developing mouse kidneyHyun Wook Lee
Department of Anatomy and MRC for Cell Death Disease Research Center, College of Medicine, The Catholic University of Korea, 505, Banpo dong, Seocho Ku, Seoul, 137 701, Korea
Cell Tissue Res 343:429-44. 2011..However, in the developing mouse kidney, LYVE-1 was also expressed transiently in F4/80(+)/CD11b(-) immature macrophages/dendritic cells and in the developing renal vein...
- IL-33 expands suppressive CD11b+ Gr-1(int) and regulatory T cells, including ST2L+ Foxp3+ cells, and mediates regulatory T cell-dependent promotion of cardiac allograft survivalHeth R Turnquist
Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Immunol 187:4598-610. 2011..IL-33 expands functional myeloid-derived suppressor cells, CD11b(+) cells that exhibit intermediate (int) levels of Gr-1 and potent T cell suppressive function...
- Urokinase-type plasminogen activator promotes paracellular transmigration of neutrophils via Mac-1, but independently of urokinase-type plasminogen activator receptorChristoph A Reichel
Walter Brendel Centre of Experimental Medicine, Munich, Germany
Circulation 124:1848-59. 2011..Urokinase-type plasminogen activator (uPA) has recently been implicated in the pathogenesis of ischemia-reperfusion (I/R) injury. The underlying mechanisms remain largely unclear...
- Binding of CD40L to Mac-1's I-domain involves the EQLKKSKTL motif and mediates leukocyte recruitment and atherosclerosis--but does not affect immunity and thrombosis in miceDennis Wolf
Atherogenesis Research Group, Department of Cardiology, University of Freiburg, Germany
Circ Res 109:1269-79. 2011..We recently reported that CD40L mediates atherogenesis independently of CD40 and proposed Mac-1 as an alternate receptor...
- CD14 cooperates with complement receptor 3 to mediate MyD88-independent phagocytosis of Borrelia burgdorferiKelly L Hawley
Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01003, USA
Proc Natl Acad Sci U S A 109:1228-32. 2012..to different receptors on the surface of phagocytic cells, including the β(2) integrin, complement receptor 3 (CR3). However, whether these receptors mediate the phagocytosis of the spirochete remains unknown...
- Activation of the classical complement pathway by Bacillus anthracis is the primary mechanism for spore phagocytosis and involves the spore surface protein BclAChunfang Gu
Institute of Biosciences and Technology, Texas A and M Health Science Center, Houston, TX 77030, USA
J Immunol 188:4421-31. 2012..These findings are likely to have significant implications on B. anthracis pathogenesis and microbial manipulation of complement...
- Integrin CD11b negatively regulates TLR9-triggered dendritic cell cross-priming by upregulating microRNA-146aYi Bai
National Key Laboratory of Medical Immunology, Institute of Immunology, Second Military Medical University, Shanghai 200433, China
J Immunol 188:5293-302. 2012..Our previous studies showed that β2 integrin CD11b could control TLR-triggered NK cell cytotoxicity and macrophage inflammatory responses...
- NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared nicheChiung Ying Chang
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10065, USA
Nature 495:98-102. 2013..Our findings reveal how melanocyte and hair follicle stem cell behaviours maintain reliance upon cooperative factors within the niche, and how this can be uncoupled in injury, stress and disease states...
- Use of a photoactivatable taxol analogue to identify unique cellular targets in murine macrophages: identification of murine CD18 as a major taxol-binding protein and a role for Mac-1 in taxol-induced gene expressionN Bhat
Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
J Immunol 162:7335-42. 1999..Since CD18 has been described as a participant in LPS-induced binding and signal transduction, these data support the hypothesis that the interaction of murine CD18 with Taxol is involved in its proinflammatory activity...
- Exploiting type 3 complement receptor for TNF-alpha suppression, immune evasion, and progressive pulmonary fungal infectionT Tristan Brandhorst
Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
J Immunol 173:7444-53. 2004TNF-alpha is crucial in defense against intracellular microbes. Host immune cells use type 3 complement receptors (CR3) to regulate excess TNF-alpha production during physiological clearance of apoptotic cells...
- Microglial Cell Activation by Thrombin in StrokeJonathan Weinstein; Fiscal Year: 2008..unreadable] [unreadable]..
- NEUTROPHIL RECRUITMENT IN LPS-INDUCED AIRWAY DISEASEJessica Moreland; Fiscal Year: 2004....
- The Mechanism of IVIG Action in PemphigusZhi Liu; Fiscal Year: 2006..The overall goal of this project is to study the mechanisms of WIG action in autoantibody-mediated diseases and develop novel therapies to replace current immunosuppressive treatments, which confer severe side effects. ..
- Role of CIC-3 channels in regulation of cell volume and shape in neutrophilsJessica Moreland; Fiscal Year: 2007..The studies proposed will advance our fundamental knowledge of the function of neutrophils in the maintenance of normal immune system function. [unreadable] [unreadable] [unreadable]..
- Investigation of Nod2: Implications for UveitisHolly Rosenzweig; Fiscal Year: 2008..Together, these studies will provide valuable new information on how Nod2 is involved in autoimmunity and the pathogeneis of uveitis. ..
- Arbovirus Evasion of Type I Interferon InductionMark Heise; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Improved Vaccines for Rift Valley Fever VirusMark T Heise; Fiscal Year: 2010....
- TOGAVIRUS TROPISM FOR BONES, JOINTS, AND CNSMark T Heise; Fiscal Year: 2010....