Itga7

Summary

Gene Symbol: Itga7
Description: integrin alpha 7
Alias: alpha7, integrin alpha-7
Species: mouse

Top Publications

  1. ncbi Beta1 integrins in muscle, but not in motor neurons, are required for skeletal muscle innervation
    Martin Schwander
    Department of Cell Biology and Institute for Childhood and Neglected Disease, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 24:8181-91. 2004
  2. ncbi Role for the alpha7beta1 integrin in vascular development and integrity
    Nichole L Flintoff-Dye
    Department of Pharmacology, University of Nevada, Manville Health Science Building, Reno, 89557, USA
    Dev Dyn 234:11-21. 2005
  3. pmc Activation of AKT signaling promotes cell growth and survival in α7β1 integrin-mediated alleviation of muscular dystrophy
    Marni D Boppart
    Department of Kinesiology and Community Health, University of Illinois, Urbana, IL 61801, USA
    Biochim Biophys Acta 1812:439-46. 2011
  4. ncbi Activation of c-Raf-1 kinase signal transduction pathway in alpha(7) integrin-deficient mice
    G Saher
    Max Planck Institut fur Biochemie, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    J Biol Chem 274:27651-7. 1999
  5. ncbi A new isoform of the laminin receptor integrin alpha 7 beta 1 is developmentally regulated in skeletal muscle
    G Collo
    Department of Cell Biology, Scripps Research Institute, La Jolla, California 92037
    J Biol Chem 268:19019-24. 1993
  6. ncbi Distinct alpha 7A beta 1 and alpha 7B beta 1 integrin expression patterns during mouse development: alpha 7A is restricted to skeletal muscle but alpha 7B is expressed in striated muscle, vasculature, and nervous system
    T Velling
    Department of Animal Physiology, Uppsala University, Sweden
    Dev Dyn 207:355-71. 1996
  7. doi The α7β1-integrin accelerates fiber hypertrophy and myogenesis following a single bout of eccentric exercise
    Tara N Lueders
    Department of Kinesiology and Community Health, University of Illinois, Urbana, USA
    Am J Physiol Cell Physiol 301:C938-46. 2011
  8. ncbi Absence of integrin alpha 7 causes a novel form of muscular dystrophy
    U Mayer
    Max Planck Institute for Biochemistry, Martinsried, Germany
    Nat Genet 17:318-23. 1997
  9. pmc Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions
    Francesco J Conti
    The Scripps Research Institute, Department of Cell Biology and Institute of Childhood and Neglected Diseases, La Jolla, CA 92037, USA
    Development 136:3597-606. 2009
  10. ncbi Laminins promote the locomotion of skeletal myoblasts via the alpha 7 integrin receptor
    C C Yao
    Department of Stomatology, School of Dentistry, University of California San Francisco 94143 0512, USA
    J Cell Sci 109:3139-50. 1996

Scientific Experts

  • Arundhati Ray
  • Janet Rossant
  • N Miosge
  • S C Previtali
  • Dean J Burkin
  • Thomas Samson
  • Stefan Plantman
  • Marni D Boppart
  • Charles ffrench-Constant
  • Thomas U Mayer
  • Jianming Liu
  • Ulrike Mayer
  • Jachinta E Rooney
  • Praveen B Gurpur
  • Stephen J Kaufman
  • Jamie L Marshall
  • Jennifer V Welser
  • Helga von der Mark
  • M Carmen Valero
  • Francesco J Conti
  • Mohamed Mlih
  • Kinga I Gawlik
  • U Mayer
  • Ulrich Muller
  • Jennifer Oh
  • Rachelle H Crosbie-Watson
  • Eric Chou
  • Marta Pellegatta
  • Nichole L Flintoff-Dye
  • Pascal Stuelsatz
  • Takashi Chaen
  • Emmanuel Debrand
  • Kai Zou
  • Madeleine Durbeej
  • Johan Holmberg
  • Poonam Jethanandani
  • Heather D Huntsman
  • Fernanda Bajanca
  • F Nitzki
  • Tara N Lueders
  • David R Critchley
  • Zipora Yablonka-Reuveni
  • Stephanie L Gupton
  • Renzhi Han
  • C C Yao
  • Noriyuki Nishioka
  • Mattias Häger
  • Cherie A Singer
  • Ania L Gheyara
  • Takako Sasaki
  • Justin D Lathia
  • J V Welser
  • Laurin M Hanft
  • G Saher
  • Paul Scowen
  • Chun Guo
  • Louis F Reichardt
  • Natalie J Gardiner
  • R H Kramer
  • Dan Strumpf
  • Zhefeng Zhao
  • M A Lopez
  • Ana Sofia Cachaço
  • Sólveig Thorsteinsdóttir
  • Ernst Poschl
  • Klaus von der Mark
  • Michael J Allikian
  • Sandra Blaess
  • Randall H Kramer
  • Martin Schwander
  • Chi Shing Chan
  • Per A R Ekstrom
  • Jianqiao Xiao
  • Joy A Lee
  • Lionel Host
  • Michael Gotthardt
  • Emmanuelle Canet-Soulas
  • Nathalie Niederhoffer
  • Francisco Abt-Jijon
  • Laurent Monassier
  • Frank Kober
  • Michael Radke
  • Philippe Boucher
  • Sophie Martin
  • Nadia Messaddeq
  • Véronique Bruban
  • Rachel L Matz
  • Monique Bernard
  • A Sonnenberg
  • Jerome Terrand

Detail Information

Publications84

  1. ncbi Beta1 integrins in muscle, but not in motor neurons, are required for skeletal muscle innervation
    Martin Schwander
    Department of Cell Biology and Institute for Childhood and Neglected Disease, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 24:8181-91. 2004
    ..We conclude that Itgb1 expression in muscle, but not in motor neurons, is critical for NMJ development...
  2. ncbi Role for the alpha7beta1 integrin in vascular development and integrity
    Nichole L Flintoff-Dye
    Department of Pharmacology, University of Nevada, Manville Health Science Building, Reno, 89557, USA
    Dev Dyn 234:11-21. 2005
    ..To identify the expression pattern of the alpha7 integrin in these tissues during embryonic development, alpha7 integrin chain knockout mice were generated by a ..
  3. pmc Activation of AKT signaling promotes cell growth and survival in α7β1 integrin-mediated alleviation of muscular dystrophy
    Marni D Boppart
    Department of Kinesiology and Community Health, University of Illinois, Urbana, IL 61801, USA
    Biochim Biophys Acta 1812:439-46. 2011
    ..We conclude that the α7β1 integrin confers a protective effect in dystrophic muscle through the activation of the ILK, AKT, p70S6K and BAD signaling to promote muscle cell survival...
  4. ncbi Activation of c-Raf-1 kinase signal transduction pathway in alpha(7) integrin-deficient mice
    G Saher
    Max Planck Institut fur Biochemie, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    J Biol Chem 274:27651-7. 1999
    ....
  5. ncbi A new isoform of the laminin receptor integrin alpha 7 beta 1 is developmentally regulated in skeletal muscle
    G Collo
    Department of Cell Biology, Scripps Research Institute, La Jolla, California 92037
    J Biol Chem 268:19019-24. 1993
    ..Splicing of alpha 7B mRNA in C2C12 occurred shortly after myogenin expression and could be an indicator of progression through the program of skeletal muscle differentiation...
  6. ncbi Distinct alpha 7A beta 1 and alpha 7B beta 1 integrin expression patterns during mouse development: alpha 7A is restricted to skeletal muscle but alpha 7B is expressed in striated muscle, vasculature, and nervous system
    T Velling
    Department of Animal Physiology, Uppsala University, Sweden
    Dev Dyn 207:355-71. 1996
    ..We conclude that the alpha 7A and alpha 7B integrin variants are expressed in a developmentally regulated, tissue-specific pattern suggesting different functions for the two splice forms...
  7. doi The α7β1-integrin accelerates fiber hypertrophy and myogenesis following a single bout of eccentric exercise
    Tara N Lueders
    Department of Kinesiology and Community Health, University of Illinois, Urbana, USA
    Am J Physiol Cell Physiol 301:C938-46. 2011
    ..Further studies are necessary to elucidate the precise mechanism by which the α(7)-integrin can enhance muscle hypertrophy following exercise...
  8. ncbi Absence of integrin alpha 7 causes a novel form of muscular dystrophy
    U Mayer
    Max Planck Institute for Biochemistry, Martinsried, Germany
    Nat Genet 17:318-23. 1997
    b>Integrin alpha 7 beta 1 is a specific cellular receptor for the basement membrane protein laminin-1 (refs 1,2), as well as for the laminin isoforms -2 and -4 (ref. 3)...
  9. pmc Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions
    Francesco J Conti
    The Scripps Research Institute, Department of Cell Biology and Institute of Childhood and Neglected Diseases, La Jolla, CA 92037, USA
    Development 136:3597-606. 2009
    ..We conclude that talin 1 and 2 are crucial for skeletal muscle development, where they regulate myoblast fusion, sarcomere assembly and the maintenance of MTJs...
  10. ncbi Laminins promote the locomotion of skeletal myoblasts via the alpha 7 integrin receptor
    C C Yao
    Department of Stomatology, School of Dentistry, University of California San Francisco 94143 0512, USA
    J Cell Sci 109:3139-50. 1996
    ..These results established that alpha 7 beta 1 receptor can promote myoblast adhesion and motility on a restricted number of laminin isoforms and may be important in myogenic precursor recruitment during regeneration and differentiation...
  11. pmc Laminin-111 protein therapy prevents muscle disease in the mdx mouse model for Duchenne muscular dystrophy
    Jachinta E Rooney
    Department of Pharmacology, University of Nevada School of Medicine, Reno, NV 89557, USA
    Proc Natl Acad Sci U S A 106:7991-6. 2009
    ..These findings demonstrate that laminin-111 is a highly potent therapeutic agent for the mdx mouse model of DMD and represents a paradigm for the systemic delivery of extracellular matrix proteins as therapies for genetic diseases...
  12. ncbi Developmental regulation of integrin expression at the time of implantation in the mouse embryo
    A E Sutherland
    Department of Stomatology, University of California San Francisco 94143
    Development 119:1175-86. 1993
    ..abstract truncated at 400 words)..
  13. pmc Exercise promotes alpha7 integrin gene transcription and protection of skeletal muscle
    Marni D Boppart
    Department of Kinesiology and Community Health, University of Illinois, Urbana, Illinois, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1623-30. 2008
    ..A single bout of downhill running exercise selectively increased transcription of the alpha7 integrin gene in 5-wk-old wild-type mice 3 h postexercise, and an increased alpha7 chain was detected in muscle ..
  14. pmc Increasing alpha 7 beta 1-integrin promotes muscle cell proliferation, adhesion, and resistance to apoptosis without changing gene expression
    Jianming Liu
    Department of Cell and Developmental Biology, University of Illinois, 601 S Goodwin Ave, B107 Chemical and Life Sciences Laboratory, Urbana, IL 61801, USA
    Am J Physiol Cell Physiol 294:C627-40. 2008
    ..These results support the use of integrin enhancement as a therapy for muscular dystrophy...
  15. pmc Laminin-111 restores regenerative capacity in a mouse model for alpha7 integrin congenital myopathy
    Jachinta E Rooney
    Department of Pharmacology, University of Nevada School of Medicine, Reno, Nevada 89557, USA
    Am J Pathol 174:256-64. 2009
    Mutations in the alpha7 integrin gene cause congenital myopathy characterized by delayed developmental milestones and impaired mobility...
  16. ncbi Synaptic integrins in developing, adult, and mutant muscle: selective association of alpha1, alpha7A, and alpha7B integrins with the neuromuscular junction
    P T Martin
    Department of Anatomy and Neurobiology, Washington University Medical School, St Louis, Missouri 63110, USA
    Dev Biol 174:125-39. 1996
    ..alpha1 chain was selectively associated with presynaptic cells (Schwann cells and/or nerve terminals), while alpha7 was present on both synaptic and extrasynaptic portions of the muscle fiber surface...
  17. ncbi Alternative extracellular and cytoplasmic domains of the integrin alpha 7 subunit are differentially expressed during development
    B L Ziober
    Department of Stomatology and Anatomy, University of California, San Francisco 94143
    J Biol Chem 268:26773-83. 1993
    ....
  18. pmc Deletion of integrin-linked kinase from skeletal muscles of mice resembles muscular dystrophy due to alpha 7 beta 1-integrin deficiency
    Ania L Gheyara
    Department of Pathology, University of California, San Francisco, San Francisco, California 94143, USA
    Am J Pathol 171:1966-77. 2007
    ..These findings resemble those seen in humans and mice lacking the alpha 7-integrin subunit and suggest that Ilk may act as a cytoplasmic effector of alpha 7 beta1-integrin in the pathogenesis of these deficiencies...
  19. pmc Eccentric exercise facilitates mesenchymal stem cell appearance in skeletal muscle
    M Carmen Valero
    Department of Kinesiology and Community Health, and Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana, Illinois, United States of America
    PLoS ONE 7:e29760. 2012
    ..The results from this study also support a role for the α7 integrin and/or mMSCs in molecular- and cellular-based therapeutic strategies that can effectively combat disuse muscle atrophy...
  20. doi Uncommitted precursor cells might contribute to increased incidence of embryonal rhabdomyosarcoma in heterozygous Patched1-mutant mice
    F Nitzki
    Department of Human Genetics, Universitatsmedizin Gottingen, Gottingen, Germany
    Oncogene 30:4428-36. 2011
    ....
  21. pmc β1D chain increases α7β1 integrin and laminin and protects against sarcolemmal damage in mdx mice
    Jianming Liu
    Department of Cell and Developmental Biology, University of Illinois, Urbana, IL 61801, USA
    Hum Mol Genet 21:1592-603. 2012
    ..Thus manipulation of β1D integrin expression offers a novel approach to enhance integrin-mediated therapy for muscular dystrophy...
  22. ncbi Skeletal myoblasts utilize a novel beta 1-series integrin and not alpha 6 beta 1 for binding to the E8 and T8 fragments of laminin
    H von Der Mark
    Max Planck Society Clinical Research Group for Rheumatology, University of Erlangen Nurnberg, Germany
    J Biol Chem 266:23593-601. 1991
    ..However, there were distinctive differences; in particular, 2 residues were deleted in comparison with alpha 6...
  23. pmc IgSF8: a developmentally and functionally regulated cell adhesion molecule in olfactory sensory neuron axons and synapses
    Arundhati Ray
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520 8082, USA
    Mol Cell Neurosci 50:238-49. 2012
    ..These data support the hypothesis that IgSF8 facilitates OSN synapse formation...
  24. pmc A contemporary atlas of the mouse diaphragm: myogenicity, vascularity, and the Pax3 connection
    Pascal Stuelsatz
    Department of Biological Structure, School of Medicine, University of Washington, Seattle, WA 98195, USA
    J Histochem Cytochem 60:638-57. 2012
    ..The novel information in this "contemporary atlas" can be further explored in the context of diaphragm pathology and genetic disorders...
  25. pmc Estrogen-dependent uterine secretion of osteopontin activates blastocyst adhesion competence
    Takashi Chaen
    Laboratory of Animal Breeding, Department of Veterinary Medical Sciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    PLoS ONE 7:e48933. 2012
    ..These findings define for the first time specific regulatory components of an estrogen-dependent pathway coordinating blastocyst adhesion competence and uterine receptivity...
  26. pmc α6β1 and α7β1 integrins are required in Schwann cells to sort axons
    Marta Pellegatta
    San Raffaele Scientific Institute, Milano 20132, Italy, Hunter James Kelly Research Institute, University at Buffalo, State University of New York, New York 14203, Development and Stem Cells Program, Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 7104, Institut National de la Santé et de la Recherche Médicale U964, Universite de Strasbourg, Illkirch 67404, France, Department of Medicine, Children s Hospital Boston and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, Biomedical Research Centre, School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, United Kingdom, and Robert Wood Johnson Medical School, Piscataway, New Jersey, New Jersey 08854
    J Neurosci 33:17995-8007. 2013
    ....
  27. pmc The Src homology and collagen A (ShcA) adaptor protein is required for the spatial organization of the costamere/Z-disk network during heart development
    Mohamed Mlih
    From the CNRS, UMR 7213, University of Strasbourg, 67401 Illkirch, France
    J Biol Chem 290:2419-30. 2015
    ..Collectively, these results demonstrate that ShcA interacts with crucial proteins and pathways that link Z-disk and costamere...
  28. pmc Sarcospan integration into laminin-binding adhesion complexes that ameliorate muscular dystrophy requires utrophin and α7 integrin
    Jamie L Marshall
    Department of Integrative Biology and Physiology, Center for Duchenne Muscular Dystrophy
    Hum Mol Genet 24:2011-22. 2015
    ..Furthermore, we found that association of sarcospan into laminin-binding complexes is dependent on utrophin and α7β1 integrin. ..
  29. pmc Deletion of integrin α7 subunit does not aggravate the phenotype of laminin α2 chain-deficient mice
    Kinga I Gawlik
    Department of Experimental Medical Science, Muscle Biology Unit, Lund University, Sweden
    Sci Rep 5:13916. 2015
    ..have non-redundant functions we generated mice deficient in laminin α2 chain and integrin α7 subunit (dy(3K)/itga7)...
  30. pmc Laminin-binding integrin alpha 7 beta 1: functional characterization and expression in normal and malignant melanocytes
    R H Kramer
    Department of Stomatology, University of California, San Francisco 94143
    Cell Regul 2:805-17. 1991
    ..These results establish the existence of a novel integrin that binds to the E8 domain of laminin and appears to mediate cell adhesion to this ligand...
  31. ncbi Alternative splice variants of alpha 7 beta 1 integrin selectively recognize different laminin isoforms
    Helga von der Mark
    Friedrich Alexander Universitat Erlangen Nurnberg, Nikolaus Fiebiger Zentrum für Molekulare Medizin, Department of Experimental Medicine I, 91054 Erlangen, Germany
    J Biol Chem 277:6012-6. 2002
    ....
  32. pmc Mice carrying a complete deletion of the talin2 coding sequence are viable and fertile
    Emmanuel Debrand
    Department of Biochemistry, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK
    Biochem Biophys Res Commun 426:190-5. 2012
    ..However, the number of Tln2(cd/cd) pups surviving to adulthood was variable suggesting that such mice have an underlying defect...
  33. pmc Dystrophin and utrophin expression require sarcospan: loss of α7 integrin exacerbates a newly discovered muscle phenotype in sarcospan-null mice
    Jamie L Marshall
    Department of Integrative Biology and Physiology, University of California, Los Angeles, CA 90095, USA
    Hum Mol Genet 21:4378-93. 2012
    ..We demonstrate that SSPN is a necessary component of dystrophin and Utr function and that SSPN modulation of integrin signaling is required for extracellular matrix attachment and muscle force development...
  34. pmc Cre-loxP-mediated inactivation of the alpha6A integrin splice variant in vivo: evidence for a specific functional role of alpha6A in lymphocyte migration but not in heart development
    C Gimond
    Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Cell Biol 143:253-66. 1998
    ..Nevertheless, the expression of alpha6A might be necessary for optimal lymphocyte migration on laminin in certain pathological conditions...
  35. ncbi Patterns of laminins and integrins in the embryonic ventricular zone of the CNS
    Justin D Lathia
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    J Comp Neurol 505:630-43. 2007
    ....
  36. ncbi Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos
    Noriyuki Nishioka
    Laboratory for Embryonic Induction, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo, Kobe, Hyogo 650 0047, Japan
    Mech Dev 125:270-83. 2008
    ....
  37. doi Integrin-laminin interactions controlling neurite outgrowth from adult DRG neurons in vitro
    Stefan Plantman
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Mol Cell Neurosci 39:50-62. 2008
    ....
  38. pmc Cib2 binds integrin alpha7Bbeta1D and is reduced in laminin alpha2 chain-deficient muscular dystrophy
    Mattias Häger
    Department of Experimental Medical Science, Division for Cell and Matrix Biology, University of Lund, 221 84 Lund, Sweden
    J Biol Chem 283:24760-9. 2008
    ..Finally, we demonstrate that Cib2 is a calcium-binding protein that interacts with integrin alpha7Bbeta1D. Thus, our data suggest a role for Cib2 as a cytoplasmic effector of integrin alpha7Bbeta1D signaling in skeletal muscle...
  39. pmc Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis
    M Sixt
    Interdisciplinary Center for Clinical Research IZKF, Nikolaus Fiebiger Center, University of Erlangen Nuremberg, Glückstr 6, 91054 Erlangen, Germany
    J Cell Biol 153:933-46. 2001
    ....
  40. pmc Genetically determined proteolytic cleavage modulates alpha7beta1 integrin function
    Jianming Liu
    Department of Cell and Developmental Biology, University of Illinois, Urbana, Illinois 61801, USA
    J Biol Chem 283:35668-78. 2008
    ..Here we report a species-specific difference in alpha7 chains that results from an intra-peptide proteolytic cleavage, by a serine protease, at the 603RRQ605 site...
  41. ncbi Impaired axonal regeneration in alpha7 integrin-deficient mice
    A Werner
    Department of Neuromorphology, Max Planck Institute of Neurobiology, 82152 Martinsried, Germany
    J Neurosci 20:1822-30. 2000
    ..b>alpha7 and beta1 subunits were present on the axons and their growth cones in the regenerating facial nerve...
  42. pmc Valproic acid activates the PI3K/Akt/mTOR pathway in muscle and ameliorates pathology in a mouse model of Duchenne muscular dystrophy
    Praveen B Gurpur
    Department of Cell and Developmental Biology, University of Illinois, B107 CLSL, 601 S Goodwin Ave, Urbana, IL 61801, USA
    Am J Pathol 174:999-1008. 2009
    ..Transgenic overexpression of the alpha7 integrin in mdx/utrn(-/-) mice, a model of Duchenne muscular dystrophy ameliorates the disease...
  43. ncbi Organization of the myotendinous junction is dependent on the presence of alpha7beta1 integrin
    N Miosge
    Zentrum Anatomie, Abteilung Histologie, Universitat Gottingen, Germany
    Lab Invest 79:1591-9. 1999
    ..receptor alpha7beta1 is enriched at the myotendinous junctions, and mice with a targeted inactivation of the alpha7 gene develop a form of muscular dystrophy that primarily affects this structure...
  44. pmc Basal lamina strengthens cell membrane integrity via the laminin G domain-binding motif of alpha-dystroglycan
    Renzhi Han
    Howard Hughes Medical Institute, Department of Molecular Physiology, The University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 106:12573-9. 2009
    ..Here we show that both dystroglycan and integrin alpha7 contribute to force-production of muscles, but that only disruption of dystroglycan causes detachment of the basal ..
  45. pmc Myotendinous junction defects and reduced force transmission in mice that lack alpha7 integrin and utrophin
    Jennifer V Welser
    Department of Pharmacology, University of Nevada School of Medicine, Reno, NV 89557, USA
    Am J Pathol 175:1545-54. 2009
    ..Indeed, mice that lack dystrophin and alpha7 integrin (mdx/alpha7(-/-)), or dystrophin and utrophin (mdx/utr(-/-)), exhibit severe muscle pathology and die ..
  46. pmc Integrin signaling switches the cytoskeletal and exocytic machinery that drives neuritogenesis
    Stephanie L Gupton
    The Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Dev Cell 18:725-36. 2010
    ..These regulated changes and coordination of cytoskeletal and exocytic machinery may be used in other physiological contexts involving cell motility and morphogenesis...
  47. ncbi Involvement of alpha7beta1 integrin in the conditioning-lesion effect on sensory axon regeneration
    Per A R Ekstrom
    Department of Animal Physiology, University of Lund, Sweden
    Mol Cell Neurosci 22:383-95. 2003
    ..in motor and sensory neurons increases following nerve lesions and motor axon regeneration is impaired in alpha7 integrin KO mice (J. Neurosci. 20, 1822-1830)...
  48. ncbi Differential onset of expression of alpha 7 and beta 1D integrins during mouse heart and skeletal muscle development
    M Brancaccio
    Department of Genetics, Biology and Medical Chemistry, University of Torino, Italy
    Cell Adhes Commun 5:193-205. 1998
    ..In conclusion these data show that the expression of the beta 1D muscle specific integrin during development occurs much earlier in heart than in skeletal muscle and it can dimerize with different alpha subunits...
  49. ncbi Altered expression of the alpha7beta1 integrin in human and murine muscular dystrophies
    B L Hodges
    Department of Cell and Structural Biology, University of Illinois, Urbana, USA
    J Cell Sci 110:2873-81. 1997
    ..Becker muscular dystrophies indicates that the increase in the alpha7beta1 integrin is regulated at the level of alpha7 gene transcription...
  50. ncbi Spatial and temporal expression of the beta1D integrin during mouse development
    A van Der Flier
    Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam
    Dev Dyn 210:472-86. 1997
    ..The switch from the beta1A to the beta1D subunit in cardiac muscle cells coincides with the expression of alpha7. In adults there is a distinct concentration of beta1D at the myotendinous junctions of muscle fibers and at ..
  51. ncbi Functional expression of the alpha 7 integrin receptor in differentiated smooth muscle cells
    C C Yao
    Department of Stomatology, School of Dentistry, University of California San Francisco, 94143, USA
    J Cell Sci 110:1477-87. 1997
    Expression of the alpha7 integrin is developmentally regulated and is thought to be tissue-specific for both skeletal and cardiac muscles...
  52. ncbi Differential expression of alpha-6 and other subunits of laminin binding integrins during development of the murine heart
    B P Hierck
    Department of Anatomy and Embryology, Leiden University, The Netherlands
    Dev Dyn 206:100-11. 1996
    ..This study suggests a distinct role for alpha-6-beta-1 in the heart and provides insight concerning probably important roles of integrins and their extracellular matrix ligands during embryonic development...
  53. ncbi Identification and characterization of the cell type-specific and developmentally regulated alpha7 integrin gene promoter
    B L Ziober
    Department of Stomatology, University of California, San Francisco, California 94143 0512, USA
    J Biol Chem 271:22915-22. 1996
    Expression of alpha7 is mainly confined to skeletal and cardiac muscle in which it appears to be the major laminin-binding integrin. When myoblasts differentiate to myotubes, alpha7 mRNA and protein expression is up-regulated...
  54. ncbi Differential expression of laminin chain-specific mRNA transcripts during mouse preimplantation embryo development
    C Shim
    Department of Molecular Biology, Seoul National University, South Korea
    Mol Reprod Dev 44:44-55. 1996
    ..The uterine environment enclosing the preimplantation embryos appears, therefore, to play an important role in the regulation of laminin gene expression during blastocyst development...
  55. ncbi Processing of ADP-ribosylated integrin alpha 7 in skeletal muscle myotubes
    A Zolkiewska
    Pulmonary Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1434, USA
    J Biol Chem 270:9227-33. 1995
    b>Integrin alpha 7 is a major substrate in skeletal muscle cells for the cell surface, glycosylphosphatidylinositol-anchored, arginine-specific ADP-ribosyltransferase...
  56. pmc H36-alpha 7 is a novel integrin alpha chain that is developmentally regulated during skeletal myogenesis
    W K Song
    Department of Cell and Structural Biology, University of Illinois, Urbana 61801
    J Cell Biol 117:643-57. 1992
    ..We conclude that H36-alpha 7 is a novel alpha integrin laminin binding protein whose expression is developmentally regulated during skeletal myogenesis...
  57. ncbi Alpha7 integrin mediates neurite outgrowth of distinct populations of adult sensory neurons
    Natalie J Gardiner
    School of Biological Sciences, University of Manchester, Manchester, M13 9PT, UK
    Mol Cell Neurosci 28:229-40. 2005
    ..Following sciatic nerve crush, alpha7 integrin is expressed by medium-large diameter, NF200-immunoreactive (IR), and medium diameter, CGRP-IR, neurons, ..
  58. ncbi TGF-beta 1 regulates adhesion of mucosal mast cell homologues to laminin-1 through expression of integrin alpha 7
    Anne Rosbottom
    Department of Veterinary Pathology, University of Edinburgh, Roslin, Midlothian, UK EH25 9RG
    J Immunol 169:5689-95. 2002
    ..05), demonstrating a novel role for this molecule in adhesion of a hemopoietic cell to laminin-1...
  59. ncbi Schwann cells synthesize alpha7beta1 integrin which is dispensable for peripheral nerve development and myelination
    S C Previtali
    Neuropathology Unit, San Raffaele Scientific Institute, Milan, Italy
    Mol Cell Neurosci 23:210-8. 2003
    ..The expression of alpha7 appears postnatally, such that alpha7beta1 is the last laminin receptor expressed by differentiating Schwann cells...
  60. ncbi Expression of laminin receptors in schwann cell differentiation: evidence for distinct roles
    Stefano C Previtali
    Neuropathology Unit, Department of Neuroscience and DIBIT, San Raffaele Scientific Institute, 20132 Milan, Italy
    J Neurosci 23:5520-30. 2003
    ..These data suggest that the action of laminin is mediated by beta1 integrins during axonal sorting and by dystroglycan, alpha6beta1, and alpha6beta4 integrins during myelination...
  61. ncbi Integrin requirement for hippocampal synaptic plasticity and spatial memory
    Chi Shing Chan
    Department of Molecular and Cellular Biology, Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 23:7107-16. 2003
    ..These results demonstrate that several different integrins are involved in physiological plasticity and provide the first evidence of their requirement for behavioral plasticity in vertebrates...
  62. pmc Lineage allocation and asymmetries in the early mouse embryo
    Janet Rossant
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada
    Philos Trans R Soc Lond B Biol Sci 358:1341-8; discussion 1349. 2003
    ....
  63. ncbi Regulation of alpha7 integrin expression during muscle differentiation
    Jianqiao Xiao
    Departments of Stomatology and Anatomy, University of California at San Francisco, San Francisco, California 94143 0422, USA
    J Biol Chem 278:49780-8. 2003
    Expression of the laminin-binding alpha7 integrin is tightly regulated during myogenic differentiation, reflecting required functions that range from cell motility to formation of stable myotendinous junctions...
  64. pmc Beta1-integrins are critical for cerebellar granule cell precursor proliferation
    Sandra Blaess
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 24:3402-12. 2004
    ....
  65. ncbi The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor
    Thomas Samson
    Lehrstuhl für Experimentelle Medizin I, Nikolaus Fiebiger Zentrum für Molekulare Medizin, Friedrich Alexander Universitat Erlangen Nurnberg, Glückstrasse 6, 91054 Erlangen, Germany
    J Biol Chem 279:28641-52. 2004
    ..However, in cardiac and skeletal muscles, FHL2 and FHL3, respectively, are colocalized with alpha(7)beta(1) integrin receptor at the periphery of Z-discs, suggesting a role in mechanical stabilization of muscle cells...
  66. ncbi Genetic compensation for sarcoglycan loss by integrin alpha7beta1 in muscle
    Michael J Allikian
    Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    J Cell Sci 117:3821-30. 2004
    ..Mice lacking integrin alpha7 develop mild muscle degeneration, while sarcoglycan mutant mice display overt muscle degeneration and muscular ..
  67. pmc ADP-ribosylation of integrin alpha7 modulates the binding of integrin alpha7beta1 to laminin
    Zhefeng Zhao
    Department of Biochemistry, Kansas State University, 104 Willard Hall, Manhattan, KS 66506, USA
    Biochem J 385:309-17. 2005
    The extracellular domain of integrin alpha7 is ADP-ribosylated by an arginine-specific ecto-ADP-ribosyltransferase after adding exogenous NAD+ to intact C2C12 skeletal muscle cells...
  68. ncbi Integrins in the mouse myotome: developmental changes and differences between the epaxial and hypaxial lineage
    Fernanda Bajanca
    Departamento de Biologia Animal, Centro de Biologia Ambiental, Faculdade de Ciencias, Universidade de Lisboa, Lisboa, Portugal
    Dev Dyn 231:402-15. 2004
    ..Here, we describe the expression patterns of the alpha1, alpha4, alpha5, alpha6, and alpha7 integrin subunits in the mouse myotome and correlate them with the expression of several differentiation markers...
  69. ncbi Force transmission, compliance, and viscoelasticity are altered in the alpha7-integrin-null mouse diaphragm
    M A Lopez
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Am J Physiol Cell Physiol 288:C282-9. 2005
    Alpha7beta1 integrin is a transmembrane structural and receptor protein of skeletal muscles, and the absence of alpha7-integrin causes muscular dystrophy...
  70. pmc Placental defects in alpha7 integrin null mice
    J V Welser
    Department of Pharmacology, University of Nevada, Reno, NV 89557, USA
    Placenta 28:1219-28. 2007
    ..Loss of the alpha7 integrin chain results in partial embryonic lethality...
  71. ncbi Integrin repertoire on myogenic cells changes during the course of primary myogenesis in the mouse
    Ana Sofia Cachaço
    Departamento de Biologia Animal, Centro de Biologia Ambiental, Faculdade de Ciencias, Universidade de Lisboa, Lisboa, Portugal
    Dev Dyn 232:1069-78. 2005
    ..Thus, myogenic cells change their integrin expression pattern during the course of primary myogenesis in the mouse, suggesting different roles for fibronectin- and laminin-containing matrices in this process...
  72. ncbi Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst
    Dan Strumpf
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto M5G 1X5, Ontario, Canada
    Development 132:2093-102. 2005
    ..Thus, Cdx2 is essential for segregation of the ICM and TE lineages at the blastocyst stage by ensuring repression of Oct4 and Nanog in the TE...
  73. ncbi An intrinsic distinction in neuromuscular junction assembly and maintenance in different skeletal muscles
    San Pun
    Friedrich Miescher Institute, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Neuron 34:357-70. 2002
    ..Our results show that postsynaptic differentiation processes intrinsic to FaSyn and DeSyn muscles influence the formation of NMJs during development and their maintenance in the adult...
  74. ncbi Alpha7beta1-integrin regulates mechanotransduction and prevents skeletal muscle injury
    Marni D Boppart
    Dept of Cell and Developmental Biology, University of Illinois, Urbana, IL 61801, USA
    Am J Physiol Cell Physiol 290:C1660-5. 2006
    ..These experiments provide the first evidence that alpha7beta1-integrin is a negative regulator of mechanotransduction in vivo and provides resistance to exercise-induced muscle damage...
  75. ncbi Absence of alpha 7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophy
    Chun Guo
    Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    Hum Mol Genet 15:989-98. 2006
    ..Absence of either dystrophin or alpha7 integrin results in a muscular dystrophy...
  76. ncbi Severe muscular dystrophy in mice that lack dystrophin and alpha7 integrin
    Jachinta E Rooney
    Department of Pharmacology, University of Nevada, Reno, 89557, USA
    J Cell Sci 119:2185-95. 2006
    ..Mutations in the alpha7 integrin gene cause congenital myopathy in humans and mice...
  77. pmc Cytoplasmic gamma-actin expression in diverse animal models of muscular dystrophy
    Laurin M Hanft
    Department of Physiology, University of Wisconsin, Madison, WI, United States
    Neuromuscul Disord 17:569-74. 2007
    ..other dystrophic animal models, including mice deficient in beta-sarcoglycan, alpha-dystrobrevin, laminin-2, or alpha7 integrin...
  78. ncbi Distinct acidic clusters and hydrophobic residues in the alternative splice domains X1 and X2 of alpha7 integrins define specificity for laminin isoforms
    Helga von der Mark
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuernberg, 91054 Erlangen, Germany
    J Mol Biol 371:1188-203. 2007
    ..different laminin isoforms is defined by the X1 and X2 splice domains located in the beta-propeller domain of the alpha7 subunit...
  79. ncbi Loss of the alpha7 integrin promotes extracellular signal-regulated kinase activation and altered vascular remodeling
    Jennifer V Welser
    Department of Pharmacology, University of Nevada School of Medicine, Reno, NV 89557, USA
    Circ Res 101:672-81. 2007
    ..In this study, we show that loss of the alpha7 integrin in VSMCs results in activation of the extracellular signal-regulated kinase and translocation of the ..
  80. ncbi Secondary reduction of alpha7B integrin in laminin alpha2 deficient congenital muscular dystrophy supports an additional transmembrane link in skeletal muscle
    R D Cohn
    Department of Pediatrics, University of Essen, Germany
    J Neurol Sci 163:140-52. 1999
    ..The main binding partners of the alpha7 integrin are laminin-1 (alpha1-beta1-gamma1), laminin-2 (alpha2-beta1-gamma1) and laminin-4 (alpha2-beta2-gamma1)...
  81. ncbi Alpha7 integrin expression is negatively regulated by deltaEF1 during skeletal myogenesis
    Poonam Jethanandani
    Department of Cell and Tissue Biology, University of California, San Francisco, California 94143 0640, USA
    J Biol Chem 280:36037-46. 2005
    b>Alpha7 integrin levels increase dramatically as myoblasts differentiate to myotubes. A negative regulatory element with putative sites for deltaEF1 is present in the alpha7 proximal promoter region...
  82. pmc Expression of a developmentally regulated antigen on the surface of skeletal and cardiac muscle cells
    S J Kaufman
    J Cell Biol 100:1977-87. 1985
    ..We conclude that H36 is a muscle-specific, developmentally regulated cell-surface antigen that may have a role in myoblast differentiation and that can be used to determine the embryonic lineages of skeletal and cardiac muscle...
  83. ncbi Trophoblast-specific expression and function of the integrin alpha 7 subunit in the peri-implantation mouse embryo
    E Klaffky
    Department of Cell Biology, University of Virginia Health System, Charlottesville, Virginia 22908 0732, USA
    Dev Biol 239:161-75. 2001
    ..We have identified integrin alpha 7 beta 1 as a major receptor for trophoblast-laminin interactions during implantation and yolk sac placenta ..
  84. ncbi Def-6, a guanine nucleotide exchange factor for Rac1, interacts with the skeletal muscle integrin chain alpha7A and influences myoblast differentiation
    Thomas Samson
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 282:15730-42. 2007
    Integrin alpha7beta1 is the major laminin binding integrin receptor of muscle cells. The alpha7 chain occurs in several splice isoforms, of which alpha7A and alpha7B differ in their intracellular domains only...