Irf8

Summary

Gene Symbol: Irf8
Description: interferon regulatory factor 8
Alias: AI893568, ICSBP, IRF-8, Icsbp1, Myls, interferon regulatory factor 8, interferon consensus sequence binding protein 1, interferon consensus sequence-binding protein
Species: mouse

Top Publications

  1. pmc ICSBP is essential for the development of mouse type I interferon-producing cells and for the generation and activation of CD8alpha(+) dendritic cells
    Giovanna Schiavoni
    Laboratory of Virology, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Exp Med 196:1415-25. 2002
  2. pmc LXRα regulates macrophage arginase 1 through PU.1 and interferon regulatory factor 8
    Benoit Pourcet
    Centre for Clinical Pharmacology, Division of Medicine, University College London, London, United Kingdom
    Circ Res 109:492-501. 2011
  3. pmc Induction of IFN-beta and the innate antiviral response in myeloid cells occurs through an IPS-1-dependent signal that does not require IRF-3 and IRF-7
    Stephane Daffis
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Pathog 5:e1000607. 2009
  4. pmc Interferon (IFN) consensus sequence-binding protein, a transcription factor of the IFN regulatory factor family, regulates immune responses in vivo through control of interleukin 12 expression
    N A Giese
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0760, USA
    J Exp Med 186:1535-46. 1997
  5. ncbi Cutting edge: IFN consensus sequence binding protein/IFN regulatory factor 8 drives the development of type I IFN-producing plasmacytoid dendritic cells
    Hideki Tsujimura
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 170:1131-5. 2003
  6. pmc IFN regulatory factor 8 restricts the size of the marginal zone and follicular B cell pools
    Jianxun Feng
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 186:1458-66. 2011
  7. pmc Regulation of apoptosis in myeloid cells by interferon consensus sequence-binding protein
    L Gabriele
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0760, USA
    J Exp Med 190:411-21. 1999
  8. ncbi ICSBP directs bipotential myeloid progenitor cells to differentiate into mature macrophages
    T Tamura
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Immunity 13:155-65. 2000
  9. ncbi Icsbp1/IRF-8 is required for innate and adaptive immune responses against intracellular pathogens
    Karine Turcotte
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    J Immunol 179:2467-76. 2007
  10. pmc Cutting edge: IRF8 regulates Bax transcription in vivo in primary myeloid cells
    Jine Yang
    Key Laboratory of Gene Engineering of Ministry of Education, School of Life Sciences, Sun Yat Sen University, Guangzhou, 510275, China
    J Immunol 187:4426-30. 2011

Research Grants

Scientific Experts

  • Huabao Xiong
  • N A Giese
  • Vincent E Sollars
  • H C Morse
  • Tomohiko Tamura
  • Christine L White
  • ROBERTO G BACCALA
  • Haiyan S Li
  • Chen Feng Qi
  • Jeff X Zhou
  • Hongsheng Wang
  • L Gabriele
  • Fabrizio Mattei
  • Yuekang Xu
  • T Hara
  • David Mullins
  • Keiko Ozato
  • Prafullakumar Tailor
  • Hideki Tsujimura
  • Harinder Singh
  • Maike Schwieger
  • Philippe Gros
  • Jianguo Liu
  • Karine Turcotte
  • Shibin Ma
  • Hee Jeong Kong
  • Jean Francois Marquis
  • Runqing Lu
  • Carol Stocking
  • Dafeng Yang
  • Kebin Liu
  • Chang Hoon Lee
  • Dong Mi Shin
  • Alan Sher
  • Jine Yang
  • Xiaolin Hu
  • Michal Alter-Koltunoff
  • Brian T Edelson
  • Baohong Zhao
  • Andrea Schuler
  • Trina J Stewart
  • Simanta Pathak
  • Ji Young Kim
  • Weiqi Huang
  • Kristy M Greeneltch
  • Long Trinh
  • Giovanna Schiavoni
  • Elizabeth A Eklund
  • Andreas Burchert
  • Leopoldo Laricchia-Robbio
  • Chen Zhu
  • Chunliu Zhu
  • Susan Gauthier
  • Roxane Tussiwand
  • Takahiro Masuda
  • Haixia Xu
  • Amy M Becker
  • Tsung Hsien Chang
  • Makoto Horiuchi
  • Ansuman T Satpathy
  • Paola Borghi
  • Theresa L Murphy
  • Xinshou Ouyang
  • Kenneth M Murphy
  • Gilles Besin
  • Mary Zimmerman
  • Benoit Pourcet
  • Jianxun Feng
  • Drew G Michael
  • Deepta Bhattacharya
  • Wumesh Kc
  • Matthew A Smith
  • Jörn C Albring
  • Huan Ning
  • Jianjun Yang
  • Lionel B Ivashkiv
  • Xiaoyu Hu
  • I Horak
  • Seung Hee Jo
  • Jidong Zhang
  • Sergio A Lira
  • Julio Aliberti
  • Irina L Tourkova
  • Valentina Nardi
  • Jessica Koenigsmann
  • Andrea la Sala
  • Ludovic Desvignes
  • Stephane Daffis
  • Florent Ginhoux
  • Malay Mandal

Detail Information

Publications106 found, 100 shown here

  1. pmc ICSBP is essential for the development of mouse type I interferon-producing cells and for the generation and activation of CD8alpha(+) dendritic cells
    Giovanna Schiavoni
    Laboratory of Virology, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Exp Med 196:1415-25. 2002
    Interferon (IFN) consensus sequence-binding protein (ICSBP) is a transcription factor playing a critical role in the regulation of lineage commitment, especially in myeloid cell differentiation...
  2. pmc LXRα regulates macrophage arginase 1 through PU.1 and interferon regulatory factor 8
    Benoit Pourcet
    Centre for Clinical Pharmacology, Division of Medicine, University College London, London, United Kingdom
    Circ Res 109:492-501. 2011
    ..In addition, LXRα levels are high in regressive plaques. Macrophage arginase 1 (Arg1) expression is inversely correlated with atherosclerosis progression and is markedly decreased in foam cells within the lesion...
  3. pmc Induction of IFN-beta and the innate antiviral response in myeloid cells occurs through an IPS-1-dependent signal that does not require IRF-3 and IRF-7
    Stephane Daffis
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Pathog 5:e1000607. 2009
    ....
  4. pmc Interferon (IFN) consensus sequence-binding protein, a transcription factor of the IFN regulatory factor family, regulates immune responses in vivo through control of interleukin 12 expression
    N A Giese
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0760, USA
    J Exp Med 186:1535-46. 1997
    Mice with a null mutation of the gene encoding interferon consensus sequence-binding protein (ICSBP) develop a chronic myelogenous leukemia-like syndrome and mount impaired responses to certain viral and bacterial infections...
  5. ncbi Cutting edge: IFN consensus sequence binding protein/IFN regulatory factor 8 drives the development of type I IFN-producing plasmacytoid dendritic cells
    Hideki Tsujimura
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 170:1131-5. 2003
    IFN consensus sequence binding protein (ICSBP/IFN regulatory factor 8) is a hematopoietic cell-specific transcription factor essential for the generation of CD8 alpha(+) dendritic cells (DCs)...
  6. pmc IFN regulatory factor 8 restricts the size of the marginal zone and follicular B cell pools
    Jianxun Feng
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 186:1458-66. 2011
    ..In this article, we demonstrate that IRF8 is also required for normal development of MZ and FO B cells...
  7. pmc Regulation of apoptosis in myeloid cells by interferon consensus sequence-binding protein
    L Gabriele
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0760, USA
    J Exp Med 190:411-21. 1999
    Mice with a null mutation of the gene encoding interferon consensus sequence-binding protein (ICSBP) develop a disease with marked expansion of granulocytes and macrophages that frequently progresses to a fatal blast crisis, thus ..
  8. ncbi ICSBP directs bipotential myeloid progenitor cells to differentiate into mature macrophages
    T Tamura
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Immunity 13:155-65. 2000
    During hematopoiesis, myeloid progenitor cells give rise to granulocytes and macrophages. To study the role for ICSBP, a hematopoietic cell-specific transcription factor in myeloid cell development, the gene was introduced into myeloid ..
  9. ncbi Icsbp1/IRF-8 is required for innate and adaptive immune responses against intracellular pathogens
    Karine Turcotte
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    J Immunol 179:2467-76. 2007
    ..the BXH-2 mouse strain (Mus musculus) is caused by a recessive mutation (R294C) in the transcriptional regulator Icsbp1/IRF-8. In trans activation assays using an IL-12p40 gene reporter construct introduced in RAW 264...
  10. pmc Cutting edge: IRF8 regulates Bax transcription in vivo in primary myeloid cells
    Jine Yang
    Key Laboratory of Gene Engineering of Ministry of Education, School of Life Sciences, Sun Yat Sen University, Guangzhou, 510275, China
    J Immunol 187:4426-30. 2011
    A prominent phenotype of IRF8 knockout (KO) mice is the uncontrolled expansion of immature myeloid cells. The molecular mechanism underlying this myeloproliferative syndrome is still elusive...
  11. pmc Positive regulatory domain I (PRDM1) and IRF8/PU.1 counter-regulate MHC class II transactivator (CIITA) expression during dendritic cell maturation
    Matthew A Smith
    H Lee Moffitt Cancer Center and Research Institute, Department of Molecular Medicine, University of South Florida, Tampa, Florida 33612, USA
    J Biol Chem 286:7893-904. 2011
    ..In immature DCs transcription requires binding of PU.1, IRF8, NFκB, and Sp1 to the promoter. PU...
  12. ncbi ICSBP/IRF-8 inhibits mitogenic activity of p210 Bcr/Abl in differentiating myeloid progenitor cells
    Tomohiko Tamura
    Bldg 6, Rm 2A01, Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, 6 Center Dr MSC 2753, Bethesda, MD 20892 2753, USA
    Blood 102:4547-54. 2003
    b>Interferon consensus sequence binding protein/interferon regulatory factor 8 (ICSBP/IRF-8) is a transcription factor that controls myeloid cell development. ICSBP-/- mice develop a chronic myelogenous leukemia (CML)-like syndrome...
  13. pmc Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction
    T Scharton-Kersten
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 2753, USA
    J Exp Med 186:1523-34. 1997
    Mice lacking the transcription factor interferon consensus sequence binding protein (ICSBP), a member of the interferon regulatory factor family of transcription proteins, were infected with the intracellular protozoan, Toxoplasma gondii...
  14. ncbi IFN consensus sequence binding protein/IFN regulatory factor-8 guides bone marrow progenitor cells toward the macrophage lineage
    Hideki Tsujimura
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 169:1261-9. 2002
    IFN consensus sequence binding protein (ICSBP; IFN regulatory factor-8) is a transcription factor of the IFN regulatory factor family. Disruption of this gene results in a leukemia-like disease in mice...
  15. ncbi Complex formation of the interferon (IFN) consensus sequence-binding protein with IRF-1 is essential for murine macrophage IFN-gamma-induced iNOS gene expression
    Huabao Xiong
    Immunobiology Center, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 278:2271-7. 2003
    This study describes the role of the interferon (IFN) consensus sequence-binding protein (ICSBP or IRF-8) in iNOS gene expression by murine macrophages...
  16. pmc Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development
    Malay Mandal
    Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA
    Nat Immunol 10:1110-7. 2009
    ..Our data show how pre-BCR signaling poises pre-B cells to undergo differentiation after escape from IL-7R signaling...
  17. pmc Modulating the expression of IFN regulatory factor 8 alters the protumorigenic behavior of CD11b+Gr-1+ myeloid cells
    Trina J Stewart
    Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 183:117-28. 2009
    ....
  18. ncbi The interferon regulatory factor ICSBP/IRF-8 in combination with PU.1 up-regulates expression of tumor suppressor p15(Ink4b) in murine myeloid cells
    Martina Schmidt
    Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, MD 20892 4263, USA
    Blood 103:4142-9. 2004
    ..Both the interferon consensus sequence-binding protein/interferon regulatory factor 8 (ICSBP/IRF-8) and PU.1 were able to increase transcription from this region...
  19. pmc Disabled-2 is transcriptionally regulated by ICSBP and augments macrophage spreading and adhesion
    Frank Rosenbauer
    Department of Molecular Genetics, Institute of Molecular Pharmacology, and Benjamin Franklin Medical Center, Free University of Berlin, Krahmerstrasse 6, D 12207 Berlin, Germany
    EMBO J 21:211-20. 2002
    Mice lacking transcription factor interferon consensus sequence binding protein (ICSBP) develop a syndrome similar to human chronic myeloid leukemia and are immunodeficient...
  20. ncbi Synergistic activation of interleukin-12 p35 gene transcription by interferon regulatory factor-1 and interferon consensus sequence-binding protein
    Jianguo Liu
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Biol Chem 279:55609-17. 2004
    Interferon regulatory factor-1 (IRF-1) and interferon consensus sequence-binding protein (ICSBP or IRF-8) are two members of the IRF family of transcription factors that play critical roles in interferon signaling in a wide range of host ..
  21. ncbi Cutting edge: autoantigen Ro52 is an interferon inducible E3 ligase that ubiquitinates IRF-8 and enhances cytokine expression in macrophages
    Hee Jeong Kong
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, 6 Center Drive, Bethesda, MD 20892, USA
    J Immunol 179:26-30. 2007
    ..Together, Ro52 is an E3 ligase for IRF-8 that acts in a non-degradation pathway of ubiquitination, and contributes to the elicitation of innate immunity in macrophages...
  22. pmc The sequestosome 1/p62 attenuates cytokine gene expression in activated macrophages by inhibiting IFN regulatory factor 8 and TNF receptor-associated factor 6/NF-kappaB activity
    Ji Young Kim
    Laboratory of Molecular Growth Regulation, Program in Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 182:2131-40. 2009
    ..Together, p62 may provide a mechanism by which to control excessive inflammatory responses after macrophage activation...
  23. pmc An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes
    P H Driggers
    Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 87:3743-7. 1990
    ..libraries with the ICS as a probe, we isolated a cDNA clone encoding a protein that binds the ICS, designated ICSBP. Protein blot analysis with labeled oligonucleotide probes showed that ICSBP binds not only the MHC class I ICS ..
  24. pmc The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3 alpha subunit (or similar) molecule binds
    Y Kanno
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, Bethesda, Maryland 20892
    Mol Cell Biol 13:3951-63. 1993
    b>ICSBP, a member of the interferon regulatory factor family, is expressed predominantly in lymphoid tissues and is induced by gamma interferon (IFN-gamma)...
  25. ncbi Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene
    T Holtschke
    Institute of Virology and Immunobiology, University of Wurzburg, Federal Republic of Germany
    Cell 87:307-17. 1996
    b>Interferon consensus sequence binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family...
  26. pmc Crucial role of interferon consensus sequence binding protein, but neither of interferon regulatory factor 1 nor of nitric oxide synthesis for protection against murine listeriosis
    T Fehr
    Institute of Experimental Immunology, University Hospital, Zurich, Switzerland
    J Exp Med 185:921-31. 1997
    ..This study investigated mouse strains deficient for the IFN-dependent transcription factors interferon consensus sequence binding protein (ICSBP), interferon regulatory factor (IRF) 1 or 2 for their capacity to eliminate Listeria in ..
  27. ncbi Altered development and cytokine responses of myeloid progenitors in the absence of transcription factor, interferon consensus sequence binding protein
    M Scheller
    Abteilung für Molekulare Genetik, Forschungsinstitut fur Molekulare Pharmakologie, und Universitätsklinikum Benjamin Franklin, Freie Universitat Berlin, Berlin, Germany
    Blood 94:3764-71. 1999
    Mice deficient for the transcription factor, interferon consensus sequence binding protein (ICSBP), are immunodeficient and develop disease symptoms similar to human chronic myeloid leukemia (CML)...
  28. ncbi Interferon consensus sequence binding protein and interferon regulatory factor-4/Pip form a complex that represses the expression of the interferon-stimulated gene-15 in macrophages
    F Rosenbauer
    Department of Molecular Genetics, Research Institute of Molecular Pharmacology, University Hospital Benjamin Franklin, Free University of Berlin, Berlin, Germany
    Blood 94:4274-81. 1999
    b>Interferon consensus sequence binding protein (ICSBP), a transcription factor of the interferon (IFN) regulatory factor (IRF) family, binds to the IFN-stimulated response element (ISRE) in the regulatory region of IFNs and IFN-stimulated ..
  29. pmc IFN consensus sequence binding protein potentiates STAT1-dependent activation of IFNgamma-responsive promoters in macrophages
    C Contursi
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:91-6. 2000
    ..We found that macrophages from ICSBP-/- mice were defective in inducing some IFNgamma-responsive genes, even though they were capable of activating ..
  30. pmc Interferon consensus sequence binding protein confers resistance against Yersinia enterocolitica
    J Hein
    Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat, Munich, Germany
    Infect Immun 68:1408-17. 2000
    b>Interferon consensus sequence binding protein (ICSBP)-deficient mice display enhanced susceptibility to intracellular pathogens. At least two distinct immunoregulatory defects are responsible for this phenotype...
  31. ncbi ICSBP/IRF-8: its regulatory roles in the development of myeloid cells
    Tomohiko Tamura
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Interferon Cytokine Res 22:145-52. 2002
    Interferon (IFN) consensus sequence binding protein (ICSBP)/IFN regulatory factor (IRF)-8 is an IFNgamma-inducible transcription factor of the IRF family and regulates transcription through multiple target DNA elements, such as IFN-..
  32. ncbi Susceptibility of IFN regulatory factor-1 and IFN consensus sequence binding protein-deficient mice to brucellosis
    Jinkyung Ko
    Laboratory of Cellular and Molecular Immunology, Department of Animal Health and Biomedical Sciences, University of Wisconsin, Madison, WI 53706, USA
    J Immunol 168:2433-40. 2002
    ..are mediated by IFN regulatory factors (IRFs) such as IRF-1, IRF-2, and IFN consensus sequence binding protein (ICSBP). However, the roles of these three IRFs in Brucella infection have not been investigated...
  33. ncbi ICSBP/IRF-8 retrovirus transduction rescues dendritic cell development in vitro
    Hideki Tsujimura
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health NIH, Bethesda, MD 20892, USA
    Blood 101:961-9. 2003
    ..b>Interferon consensus sequence binding protein (ICSBP; also called interferon regulatory factor 8 [IRF-8]) is a hematopoietic cell-specific ..
  34. ncbi Essential role for ICSBP in the in vivo development of murine CD8alpha + dendritic cells
    Julio Aliberti
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 101:305-10. 2003
    Interferon (IFN) consensus sequence-binding protein (ICSBP) is an important transcription factor regulating proinflammatory cytokine production and the development of mononuclear phagocytes in vitro...
  35. pmc AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency
    Maike Schwieger
    Department of Cell and Virus Genetics, Heinrich Pette Institut für Experimentelle Virologie und Immunologie, D 20251 Hamburg, Germany
    J Exp Med 196:1227-40. 2002
    ..To determine the significance of earlier findings that expression of the tumor suppressor ICSBP is often downregulated in AML myeloblasts, AML1-ETO was introduced into BM cells derived from mice lacking the ..
  36. pmc IRF-4,8 orchestrate the pre-B-to-B transition in lymphocyte development
    Runqing Lu
    Department of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637, USA
    Genes Dev 17:1703-8. 2003
    ..We demonstrate that the related interferon regulatory factors IRF-4 (Pip) and IRF-8 (ICSBP) are required for Ig light but not heavy-chain gene rearrangement...
  37. ncbi Activation of the murine interleukin-12 p40 promoter by functional interactions between NFAT and ICSBP
    Chen Zhu
    Immunobiology Center, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 278:39372-82. 2003
    ..In this study, a composite NFAT/ICSBP binding site at -68 to -54 is identified that is functionally important for p40 promoter activation by ..
  38. ncbi Nramp1-mediated innate resistance to intraphagosomal pathogens is regulated by IRF-8, PU.1, and Miz-1
    Michal Alter-Koltunoff
    Department of Food Engineering and Biotechnology, Technion, Haifa 32000, Israel
    J Biol Chem 278:44025-32. 2003
    ..Thus, our results explain in molecular terms the role of IRF-8 in conferring innate resistance to intracellular pathogens and point to its possible involvement in autoimmune diseases...
  39. ncbi ICSBP is critically involved in the normal development and trafficking of Langerhans cells and dermal dendritic cells
    Giovanna Schiavoni
    Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy
    Blood 103:2221-8. 2004
    Interferon consensus sequence-binding protein (ICSBP) is a transcription factor belonging to the interferon regulatory factor (IRF) family, recently shown to play a critical role in dendritic cell (DC) differentiation...
  40. ncbi Genetic control of myeloproliferation in BXH-2 mice
    Karine Turcotte
    Department of Biochemistry, McGill University, Montreal, QC, Canada H3G 1Y6
    Blood 103:2343-50. 2004
    ..The locus controlling this myeloproliferative syndrome and splenomegaly was designated Myls and maps to an 18 centimorgan (cM) region of chromosome 8, which also contains an integrated copy of an N-ecotropic ..
  41. ncbi Interferon consensus sequence binding protein (ICSBP; IRF-8) antagonizes BCR/ABL and down-regulates bcl-2
    Andreas Burchert
    Klinikum der Philipps Universität Marburg, Klinik für Hämatologie, Onkologie und Immunologie, Marburg, Germany
    Blood 103:3480-9. 2004
    ..Mice lacking expression of the interferon (IFN) consensus sequence binding protein (ICSBP), an IFN gamma-inducible transcription factor of the interferon regulatory factor (IRF) family, develop a disease ..
  42. ncbi Toll-like receptor 9 signaling activates NF-kappaB through IFN regulatory factor-8/IFN consensus sequence binding protein in dendritic cells
    Hideki Tsujimura
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 172:6820-7. 2004
    ..IRF-8 reintroduction fully restored CpG activation of NF-kappaB and cytokine induction in -/- DCs. Together, TLR signals that activate NF-kappaB are diverse among different TLRs, and TLR9 signaling uniquely depends on IRF-8 in DCs...
  43. ncbi The interferon consensus sequence-binding protein activates transcription of the gene encoding neurofibromin 1
    Chunliu Zhu
    Feinberg School of Medicine and the Robert H Lurie Comprehensive Cancer Center, Northwestern University and Chicago Lakeside Veterans Affairs Hospital, Chicago, Illinois 60611, USA
    J Biol Chem 279:50874-85. 2004
    Deficiency of the interferon consensus sequence-binding protein (ICSBP) is associated with increased myeloid cell proliferation in response to hematopoietic cytokines...
  44. ncbi IFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity
    Tomohiko Tamura
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 174:2573-81. 2005
    ..Together, IRF-4 and IRF-8 serve as a backbone of the molecular program regulating DC subset development and their functional diversity...
  45. pmc A mutation in the Icsbp1 gene causes susceptibility to infection and a chronic myeloid leukemia-like syndrome in BXH-2 mice
    Karine Turcotte
    Department of Biochemistry, McGill Cancer Center, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Exp Med 201:881-90. 2005
    ..candidates, including the interferon consensus sequence-binding protein 1 gene (Icsbp, also known as interferon regulatory factor 8 [IRF8])...
  46. ncbi Ubiquitin-dependent degradation of interferon regulatory factor-8 mediated by Cbl down-regulates interleukin-12 expression
    Huabao Xiong
    Immunobiology Center, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 280:23531-9. 2005
    ..Taken together, these results suggest that the proteasomal degradation of IRF-8 mediated by the ubiquitin E3 ligase Cbl down-regulates IL-12 expression...
  47. pmc Identification of target genes and a unique cis element regulated by IRF-8 in developing macrophages
    Tomohiko Tamura
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, 6 Center Dr, MSC 2753, Bethesda, MD 20892 2753, USA
    Blood 106:1938-47. 2005
    Interferon regulatory factor-8 (IRF-8)/interferon consensus sequence-binding protein (ICSBP) is a transcription factor that controls myeloid-cell development...
  48. pmc Partner-regulated interaction of IFN regulatory factor 8 with chromatin visualized in live macrophages
    Leopoldo Laricchia-Robbio
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 2753, USA
    Proc Natl Acad Sci U S A 102:14368-73. 2005
    ..By fluorescence recovery after photobleaching, we visualized the movement of IRF8-GFP in differentiating macrophages...
  49. pmc Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein
    Chang Hoon Lee
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:63-72. 2006
    Interferon (IFN) consensus sequence-binding protein/IFN regulatory factor 8 (IRF8) is a transcription factor that regulates the differentiation and function of macrophages, granulocytes, and dendritic cells through activation or ..
  50. ncbi ICSBP/IRF-8 differentially regulates antigen uptake during dendritic-cell development and affects antigen presentation to CD4+ T cells
    Fabrizio Mattei
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    Blood 108:609-17. 2006
    Interferon consensus sequence-binding protein (ICSBP)/interferon regulatory factor 8 (IRF-8) is a transcription factor that plays critical roles in the differentiation of defined dendritic-cell (DC) populations and in the immune response ..
  51. ncbi IFN regulatory factor 4 and 8 promote Ig light chain kappa locus activation in pre-B cell development
    Shibin Ma
    Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Immunol 177:7898-904. 2006
    ..have shown that B cell development is blocked at the pre-B cell stage in IFN regulatory factor (IRF)4 (pip) and IRF8 (IFN consensus sequence binding protein) double mutant mice (IRF4,8(-/-))...
  52. ncbi PU.1 and ICSBP control constitutive and IFN-gamma-regulated Tlr9 gene expression in mouse macrophages
    Kate Schroder
    Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane 4072, Australia
    J Leukoc Biol 81:1577-90. 2007
    ..The mRNA expression of the IRF family member IFN consensus-binding protein [(ICSBP)/IRF8] was coregulated with Tlr9 in macrophages, and constitutive and IFN-gamma-inducible Tlr9 mRNA expression was ..
  53. pmc The feedback phase of type I interferon induction in dendritic cells requires interferon regulatory factor 8
    Prafullakumar Tailor
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 27:228-39. 2007
    ..Here we studied the role of a transcription factor, IRF8, in DC induction of type I IFNs...
  54. ncbi IFN regulatory factor 8 mediates apoptosis in nonhemopoietic tumor cells via regulation of Fas expression
    Dafeng Yang
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA
    J Immunol 179:4775-82. 2007
    IFN regulatory factor 8 (IRF8) is a transcription factor that was originally identified in myeloid cells and has been shown to be essential for differentiation and function of hemopoietic cells...
  55. ncbi Host immunosurveillance controls tumor growth via IFN regulatory factor-8 dependent mechanisms
    Kristy M Greeneltch
    Laboratory of Tumor Immunology and Biology, Biostatistics and Data Management Section, National Cancer Institute, NIH, Bethesda, MD 20892 1402, USA
    Cancer Res 67:10406-16. 2007
    ..Conversely, strategies aimed at up-regulating or restoring IRF-8 expression in neoplastic cells may improve therapeutic efficacy...
  56. ncbi Innate immunity to intraphagosomal pathogens is mediated by interferon regulatory factor 8 (IRF-8) that stimulates the expression of macrophage-specific Nramp1 through antagonizing repression by c-Myc
    Michal Alter-Koltunoff
    Department of Biotechnology and Food Engineering, Technion Israel Institute of Technology, Haifa 32000, Israel
    J Biol Chem 283:2724-33. 2008
    ..that the restricted expression of Nramp1 is regulated by a myeloid cell-specific transcription factor termed IRF-8/ICSBP. It is demonstrated here that the induction of Nramp1 expression in activated macrophages is accompanied by a ..
  57. pmc The BXH2 mutation in IRF8 differentially impairs dendritic cell subset development in the mouse
    Prafullakumar Tailor
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 2753, USA
    Blood 111:1942-5. 2008
    ..Development of CD8alpha(+) DCs and pDCs requires the interferon regulatory factor 8 (IRF8)...
  58. doi The interferon consensus sequence-binding protein (ICSBP/IRF8) represses PTPN13 gene transcription in differentiating myeloid cells
    Weiqi Huang
    The Feinberg School of Medicine and the Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 283:7921-35. 2008
    The interferon consensus sequence-binding protein (ICSBP/IRF8) is an interferon regulatory factor that is expressed in myeloid and B-cells...
  59. pmc Constitutive activation of SHP2 in mice cooperates with ICSBP deficiency to accelerate progression to acute myeloid leukemia
    Iwona Konieczna
    Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Clin Invest 118:853-67. 2008
    ..b>Interferon consensus sequence binding protein (ICSBP, also known as IRF8) is an interferon-regulatory transcription factor that functions as ..
  60. doi Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling
    Kristen Johnson
    Department of Molecular Genetics and Cell Biology, University of Chicago, 929 East 57 th Street, GCIS W522, Chicago, IL 60637, USA
    Immunity 28:335-45. 2008
    ..By using Irf4-/-Irf8-/- pre-B cells, we demonstrated that two pathways converge to synergistically drive light-chain rearrangement, but ..
  61. doi Adenylate cycalse toxin of Bordetella pertussis inhibits TLR-induced IRF-1 and IRF-8 activation and IL-12 production and enhances IL-10 through MAPK activation in dendritic cells
    Fionnuala B Hickey
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    J Leukoc Biol 84:234-43. 2008
    ....
  62. pmc IRF8 regulates B-cell lineage specification, commitment, and differentiation
    Hongsheng Wang
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Blood 112:4028-38. 2008
    ..Here we identify interferon regulatory factor 8 (IRF8) as another component of this complex, and show that it also modulates lineage choice by ..
  63. ncbi IFN-gamma-induced TNF-alpha expression is regulated by interferon regulatory factors 1 and 8 in mouse macrophages
    Virginia Vila-del Sol
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, C Nicolás Cabrera, 1 Campus Cantoblanco, Universidad Autonoma de Madrid, Madrid, Spain
    J Immunol 181:4461-70. 2008
    ..In summary, IFN-gamma treatment induces TNF-alpha expression at transcriptional level requiring the coordinate action of IRF-1 and IRF-8...
  64. doi Nf1 haploinsufficiency and Icsbp deficiency synergize in the development of leukemias
    Jessica Koenigsmann
    Leibniz Institut fuer Molekulare Pharmakologie, Berlin, Germany
    Blood 113:4690-701. 2009
    Loss of neurofibromin or interferon consensus sequence binding protein (Icsbp) leads to a myeloproliferative disorder. Transcription of NF1 is directly controlled by ICSBP...
  65. pmc Disseminated and rapidly fatal tuberculosis in mice bearing a defective allele at IFN regulatory factor 8
    Jean Francois Marquis
    Centre for the Study of Host Resistance, Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    J Immunol 182:3008-15. 2009
    ..Collectively, these results identify IRF-8 as a critical regulator of host defenses against tuberculosis...
  66. pmc IFN regulatory factor 8 regulates MDM2 in germinal center B cells
    Jeff X Zhou
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    J Immunol 183:3188-94. 2009
    IFN regulatory factor 8 (IRF8) is a transcription factor that affects the differentiation and function of myeloid, dendritic, and B cells...
  67. pmc Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis
    Baohong Zhao
    Department of Biochemistry, School of Dentistry, Showa University, Shinagawa, Tokyo, Japan
    Nat Med 15:1066-71. 2009
    ..Mice deficient in Irf8 showed severe osteoporosis, owing to increased numbers of osteoclasts, and also showed enhanced bone destruction ..
  68. pmc Restriction of Legionella pneumophila replication in macrophages requires concerted action of the transcriptional regulators Irf1 and Irf8 and nod-like receptors Naip5 and Nlrc4
    Anne Fortier
    Department of Biochemistry, McGill University, McIntyre Medical Building, 3655 Promenade Sir William Osler, Room 907, Montreal, Quebec, Canada H3G 1Y6
    Infect Immun 77:4794-805. 2009
    ..pneumophila infection suggested that two members of the Irf transcriptional regulator family, Irf1 and Irf8, are regulated in response to Naip5 sensing of L. pneumophila...
  69. pmc The origin and development of nonlymphoid tissue CD103+ DCs
    Florent Ginhoux
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Exp Med 206:3115-30. 2009
    ..of fms-like tyrosine kinase 3 (Flt3) ligand, inhibitor of DNA protein 2 (Id2), and IFN regulatory protein 8 (IRF8). In contrast, lamina propria CD103(+) DCs express CD11b and develop independently of Id2 and IRF8...
  70. pmc Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells
    Brian T Edelson
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Med 207:823-36. 2010
    ..by similar patterns of gene expression and their shared developmental dependence on the transcription factor Irf8. These data provide evidence for a developmental relationship between lymphoid organ-resident CD8alpha+ cDCs and ..
  71. pmc Activation of IL-27 p28 gene transcription by interferon regulatory factor 8 in cooperation with interferon regulatory factor 1
    Jidong Zhang
    Division of Immunobiology, Department of Internal Medicine, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Biol Chem 285:21269-81. 2010
    ..family members, especially interferon regulatory factor-1 (IRF-1) and interferon regulatory factor-8 (IRF-8 or ICSBP), play important roles in interferon signaling in a wide range of host responses to infection and tumor growth...
  72. pmc Cooperation between deficiencies of IRF-4 and IRF-8 promotes both myeloid and lymphoid tumorigenesis
    Seung Hee Jo
    Rosenstiel Basic Medical Sciences Research Center and Department of Biology, Brandeis University, Waltham, MA, USA
    Blood 116:2759-67. 2010
    ..Combined losses of IRF-4 and IRF-8 therefore can cooperate in the development of both myeloid and lymphoid tumors...
  73. pmc IRF8 regulates acid ceramidase expression to mediate apoptosis and suppresses myelogeneous leukemia
    Xiaolin Hu
    Department of Biochemistry and Molecular Biology, and Cancer Center, Georgia Health Sciences University, Augusta, Georgia 30912, USA
    Cancer Res 71:2882-91. 2011
    IFN regulatory factor 8 (IRF8) is a key transcription factor for myeloid cell differentiation and its expression is frequently lost in hematopoietic cells of human myeloid leukemia patients...
  74. pmc Transcription factor IRF8 directs a silencing programme for TH17 cell differentiation
    Xinshou Ouyang
    Immunology Institute, Department of Medicine, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, New York 10029, USA
    Nat Commun 2:314. 2011
    ..Here we show that a member of interferon regulatory factor (IRF) family of transcription factors, IRF8, has a critical role in silencing T(H)17-cell differentiation...
  75. pmc Interferon regulatory factor 8 regulates pathways for antigen presentation in myeloid cells and during tuberculosis
    Jean Francois Marquis
    Department of Biochemistry, McGill University, Montreal, Canada
    PLoS Genet 7:e1002097. 2011
    IRF8 (Interferon Regulatory Factor 8) plays an important role in defenses against intracellular pathogens, including several aspects of myeloid cells function...
  76. pmc IRF8 governs expression of genes involved in innate and adaptive immunity in human and mouse germinal center B cells
    Dong Mi Shin
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
    PLoS ONE 6:e27384. 2011
    IRF8 (Interferon Regulatory Factor 8) is a transcription factor expressed throughout B cell differentiation except for mature plasma cells...
  77. pmc IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid mouse progenitors
    Amy M Becker
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Blood 119:2003-12. 2012
    ..Competitive reconstitutions using Irf8(-/-) BM demonstrated cell-intrinsic defects in the formation of CDPs and all splenic DC subsets...
  78. pmc Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization
    Haixia Xu
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, New York, USA
    Nat Immunol 13:642-50. 2012
    ..Notch-RBP-J signaling controlled expression of the transcription factor IRF8 that induced downstream M1 macrophage-associated genes...
  79. pmc IRF8 is a critical transcription factor for transforming microglia into a reactive phenotype
    Takahiro Masuda
    Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka, Fukuoka 812 8582, Japan
    Cell Rep 1:334-40. 2012
    ..Here, we identify the transcription factor interferon regulatory factor 8 (IRF8) as a critical regulator of reactive microglia...
  80. pmc The small ubiquitin-like modifier-deconjugating enzyme sentrin-specific peptidase 1 switches IFN regulatory factor 8 from a repressor to an activator during macrophage activation
    Tsung Hsien Chang
    Program in Genomics of Differentiation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 189:3548-56. 2012
    Macrophages, when activated by IFN-γ and TLR signaling, elicit innate immune responses. IFN regulatory factor 8 (IRF8) is a transcription factor that facilitates macrophage activation and innate immunity...
  81. pmc Compensatory dendritic cell development mediated by BATF-IRF interactions
    Roxane Tussiwand
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nature 490:502-7. 2012
    ..is based on the shared capacity of their leucine zipper domains to interact with non-AP1 factors such as IRF4 and IRF8 to mediate cooperative gene activation...
  82. pmc Interferon regulatory factor 8/interferon consensus sequence binding protein is a critical transcription factor for the physiological phenotype of microglia
    Makoto Horiuchi
    Department of Neurology, University of California Davis, School of Medicine, 4860 Y Street, Sacramento, CA 95817, USA
    J Neuroinflammation 9:227. 2012
    ..Interferon regulatory factor 8 (IRF8, also known as interferon consensus sequence binding protein) plays essential roles in development and function of the bone marrow-derived myeloid lineage...
  83. ncbi Differential requirement of IFN consensus sequence binding protein for the production of IL-12 and induction of Th1-type cells in response to IFN-gamma
    C Y Wu
    Clinical Immunology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 162:807-12. 1999
    ..production in vivo following infectious challenge has been designated IFN consensus sequence-binding protein (ICSBP)...
  84. pmc Gamma interferon triggers interaction between ICSBP (IRF-8) and TEL, recruiting the histone deacetylase HDAC3 to the interferon-responsive element
    Takeshi Kuwata
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 22:7439-48. 2002
    b>ICSBP (IRF-8) is a transcription factor of the IRF family expressed only in the immune system. It is induced in macrophages by gamma interferon (IFN-gamma) and contributes to macrophage functions...
  85. ncbi Interferon regulatory factor 8 regulates RANTES gene transcription in cooperation with interferon regulatory factor-1, NF-kappaB, and PU.1
    Jianguo Liu
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 281:19188-95. 2006
    ....
  86. ncbi Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening
    Kasper Hoebe
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Endotoxin Res 9:250-5. 2003
    ..The Lps2 mutation does not preclude signaling initiated by peptidoglycan or unmethylated DNA. Hence, genetic data suggest that there is at least one 'missing' component of the LPS receptor complex that has yet to be found...
  87. ncbi Toward the identification of a tolerogenic signature in IDO-competent dendritic cells
    Ciriana Orabona
    Section of Pharmacology, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06126 Perugia, Italy
    Blood 107:2846-54. 2006
    ..Down-modulation of Tyrobp involved IFN consensus sequence binding protein (ICSBP), a transcription factor also known as IRF-8...
  88. doi Lack of conventional dendritic cells is compatible with normal development and T cell homeostasis, but causes myeloid proliferative syndrome
    Tal Birnberg
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Immunity 29:986-97. 2008
    ..Our data identify a critical role of cDCs in the control of steady-state hematopoiesis, revealing a feedback loop that links peripheral cDCs to myelogenesis through soluble growth factors, such as Flt3 ligand...
  89. pmc ICSBP-mediated immune protection against BCR-ABL-induced leukemia requires the CCL6 and CCL9 chemokines
    Valentina Nardi
    Division of Hematology Oncology, Children s Hospital Boston, MA 02115, USA
    Blood 113:3813-20. 2009
    ..we show that the type I IFNs (alpha and beta) regulate expression of the IFN consensus sequence-binding protein (ICSBP) in BCR-ABL-transformed cells and as shown previously for ICSBP, induce a vaccine-like immunoprotective effect in ..
  90. pmc Interferon-gamma-responsive nonhematopoietic cells regulate the immune response to Mycobacterium tuberculosis
    Ludovic Desvignes
    Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Immunity 31:974-85. 2009
    ..These results reveal a previously unsuspected role for IFN-gamma responsiveness in nonhematopoietic cells in regulation of immunity to M. tuberculosis and illustrate the role of IDO in the inhibition of Th17 cell responses...
  91. doi IL-10 controls cystatin C synthesis and blood concentration in response to inflammation through regulation of IFN regulatory factor 8 expression
    Yuekang Xu
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    J Immunol 186:3666-73. 2011
    ..Our results also indicate that caution should be exerted when using the concentration of serum CstC as an indicator of kidney function in conditions in which inflammation may alter CstC production...
  92. pmc IFN regulatory factors 4 and 8 expression in the NOD mouse
    Gilles Besin
    Department of Pediatric, Immunology Division, Faculty of Medicine and Health Sciences, University of Sherbrooke, 3001 12th Avenue North, Sherbrooke, QC, Canada
    Clin Dev Immunol 2011:374859. 2011
    ..DCs play a crucial role in the presentation of autoantigen and activation of diabetogenic T cells, and IRF4 and IRF8 are crucial genes involved in the development of DCs...
  93. ncbi Interferon regulatory transcription factors are constitutively expressed and spatially regulated in the mouse lens
    W Li
    National Eye Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Dev Biol 210:44-55. 1999
    ..Nine IRFs have been described and they are expressed in a variety of cells, except for ICSBP and LSIRF/Pip, which are thought to be expressed exclusively in immune cells...
  94. ncbi Accumulation of c-Cbl and rapid termination of colony-stimulating factor 1 receptor signaling in interferon consensus sequence binding protein-deficient bone marrow-derived macrophages
    Axel Kallies
    Department of Molecular Genetics, Institute of Molecular Pharmacology, Medical Center Benjamin Franklin, Free University of Berlin, Germany
    Blood 99:3213-9. 2002
    Mice deficient for the transcription factor interferon consensus sequence binding protein (ICSBP) are immunodeficient and develop granulocytic leukemia...
  95. ncbi The Icsbp locus is a common proviral insertion site in mature B-cell lymphomas/plasmacytomas induced by exogenous murine leukemia virus
    Shi Liang Ma
    Department of Molecular Biology, University of Aarhus, C F Møllers Alle, Bldg 130, DK 8000 Aarhus C, Denmark
    Virology 352:306-18. 2006
    ICSBP (interferon consensus sequence binding protein)/IRF8 (interferon regulatory factor 8) is an interferon gamma-inducible transcription factor expressed predominantly in hematopoietic cells, and down-regulation of this factor has been ..
  96. ncbi Analysis of expansion of myeloid progenitors in mice to identify leukemic susceptibility genes
    Vincent E Sollars
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, Pennsylvania 19107, USA
    Mamm Genome 17:808-21. 2006
    ..Given the importance of this cell compartment in leukemia progression and the soon to be released genomic sequence of 15 mouse strains, these differences may provide a valuable tool for research into leukemia...
  97. ncbi Retroviral integration site analysis identifies ICSBP as a collaborating tumor suppressor gene in NUP98-TOP1-induced leukemia
    Rhonna M Gurevich
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Exp Hematol 34:1192-201. 2006
    ..The aim of this study was to test whether retroviral insertional mutagenesis contributes to disease onset and whether integration site analysis can identify collaborating genes...
  98. pmc Interferon regulatory factors 4 and 8 induce the expression of Ikaros and Aiolos to down-regulate pre-B-cell receptor and promote cell-cycle withdrawal in pre-B-cell development
    Shibin Ma
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198 5805, USA
    Blood 111:1396-403. 2008
    ..Thus, IRF4,8 orchestrate the transition from large pre-B to small pre-B cells by inducing the expression of Ikaros and Aiolos...
  99. doi Acceleration of chronic myeloproliferation by enforced expression of Meis1 or Meis3 in Icsbp-deficient bone marrow cells
    T Hara
    Stem Cell Project Group, The Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research, Tokyo, Japan
    Oncogene 27:3865-9. 2008
    ..Interferon consensus sequence-binding protein (ICSBP) is a tumor suppressor, whose downregulation cooperates with BCR-ABL and NUP98-TOP1 gene products to accelerate ..
  100. pmc A role for interferon regulatory factor 4 in receptor editing
    Simanta Pathak
    Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Mol Cell Biol 28:2815-24. 2008
    ..Thus, our studies identify IRF-4 as a nuclear effector of a BCR signaling pathway that promotes secondary rearrangement at the immature B-cell stage...
  101. doi The MADS transcription factor Mef2c is a pivotal modulator of myeloid cell fate
    Andrea Schuler
    Heinrich Pette Institute, Hamburg, Germany
    Blood 111:4532-41. 2008
    ....

Research Grants1

  1. Anti-Tumor Autoimmunity by lymphopenia T cell Expansion
    Roberto Baccala; Fiscal Year: 2008
    ..The results will define the role of homeostatic T cell proliferation in tumor autoimmunity, and provide new approaches to the treatment of cancer. [unreadable] [unreadable]..