Iqgap1

Summary

Gene Symbol: Iqgap1
Description: IQ motif containing GTPase activating protein 1
Alias: AA682088, D7Ertd237e, D7Ertd257e, mKIAA0051, ras GTPase-activating-like protein IQGAP1, Cdc42-Rac1 effector protein
Species: mouse

Top Publications

  1. pmc Gastric hyperplasia in mice lacking the putative Cdc42 effector IQGAP1
    S Li
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Mol Cell Biol 20:697-701. 2000
  2. ncbi IQGAP1 promotes cell motility and invasion
    Jennifer M Mataraza
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School Boston, Massachusetts 02115, USA
    J Biol Chem 278:41237-45. 2003
  3. pmc IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase-driven tumors
    Katherine L Jameson
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA
    Nat Med 19:626-30. 2013
  4. ncbi IQ-domain GTPase-activating protein 1 regulates beta-catenin at membrane ruffles and its role in macropinocytosis of N-cadherin and adenomatous polyposis coli
    Manisha Sharma
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, Westmead, New South Wales 2145, Australia
    J Biol Chem 282:8545-56. 2007
  5. pmc Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation
    Dominique T Brandt
    Institute of Pharmacology, University of Heidelberg, Heidelberg, Germany
    J Cell Biol 178:193-200. 2007
  6. pmc IQGAP1 modulates activation of B-Raf
    Jian Guo Ren
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:10465-9. 2007
  7. pmc Gene expression of IQGAPs and Ras families in an experimental mouse model for hepatocellular carcinoma: a mechanistic study of cancer progression
    Khairy M A Zoheir
    Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University P O Box 2457, Riyadh, Saudi Arabia Department of Cell Biology, National Research Centre 12622 Cairo, Egypt
    Int J Clin Exp Pathol 8:8821-31. 2015
  8. pmc The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1
    Matthew J Smith
    Ontario Cancer Institute, MaRS TMDT, Toronto, Canada
    EMBO J 29:884-96. 2010
  9. pmc The scaffolding protein IQGAP1 co-localizes with actin at the cytoplasmic face of the nuclear envelope: implications for cytoskeletal regulation
    Michael A Johnson
    Westmead Institute for Cancer Research University of Sydney Westmead Millennium Institute at Westmead Hospital Westmead, Australia
    Bioarchitecture 2:138-42. 2012
  10. pmc IQGAP1 links PDGF receptor-β signal to focal adhesions involved in vascular smooth muscle cell migration: role in neointimal formation after vascular injury
    Takashi Kohno
    Department of Pharmacology, Center for Lung and Vascular Biology, University of Illinois at Chicago, Chicago, Illinois
    Am J Physiol Cell Physiol 305:C591-600. 2013

Research Grants

  1. Molecular Mechanisms of Natural Killer Cell Activation
    Subramaniam Malarkannan; Fiscal Year: 2010
  2. MOLECULAR GENETICS OF PAR-3
    Lisa Cupit; Fiscal Year: 2004
  3. Role of IQGAP2 in platelet thrombin signaling
    VALENTINA SCHMIDT; Fiscal Year: 2004

Scientific Experts

  • Sayeepriyadarshini Anakk
  • Subramaniam Malarkannan
  • Lisa D Cupit
  • Li Wen Lai
  • Valentina A Schmidt
  • David B Sacks
  • Zhigang Li
  • Wadie F Bahou
  • Kozo Kaibuchi
  • Mauro Sbroggiò
  • Jian Guo Ren
  • Norifumi Urao
  • Takashi Watanabe
  • Khairy M A Zoheir
  • David R Natale
  • Ankit Garg
  • Inmaculada Bañón-Rodríguez
  • Guillaume Jacquemet
  • Katherine L Jameson
  • Min Hee Yi
  • Yipeng Liu
  • Chunsheng Liu
  • Tone B Enger
  • Takashi Kohno
  • Toshihide Kimura
  • Daniel D Billadeau
  • Masashi Okada
  • Miles J Dixon
  • Jacquelyn A Gorman
  • M Bhattacharya
  • Ignacio Jausoro
  • Michael A Johnson
  • Tohru Fukai
  • Masuko Ushio-Fukai
  • Ronald D McKinney
  • Mara Brancaccio
  • Alessandro Bertero
  • Emanuele De Blasio
  • Lorenzo Silengo
  • Hugh Kim
  • Emilia Turco
  • Guido Tarone
  • Can Gao
  • Sonia Sharma
  • Matthew J Smith
  • Aradhana Awasthi
  • Francesca E Gordon
  • Beric R Henderson
  • Jian Bin Wang
  • Jelena Radulovic
  • Natalie C Tronson
  • Mahasin A Osman
  • Eric N Rittmeyer
  • Hisashi Nojima
  • Anna Bielak-Zmijewska
  • Ha Won Jeong
  • Dominique T Brandt
  • Christina Schrick
  • Laurent Balenci
  • Manisha Sharma
  • Juliana Leung
  • Stanislav S Kholmanskikh
  • Xiao Li Liu
  • Jean Christophe Deloulme
  • Jacques Baudier
  • Jennifer M Mataraza
  • Sheikh Fayaz Ahmad
  • Gamaleldin I Harisa
  • Ahmed A Abd-Rabou
  • Adel R Abd-Allah
  • Sabry M Attia
  • Saleh A Bakheet
  • Hala E Abdel-Hamied
  • Abdelkader E Ashour
  • Ashok Kumar
  • Andrew J Watson
  • She Chen
  • Silvia Vergarajauregui
  • Nigel G Laing
  • Robert W Grange
  • Jason O'Rourke
  • Svetlana Bezprozvannaya
  • Manuel Gálvez-Santisteban
  • Arantxa Borreguero-Pascual
  • Chengzu Long
  • Eric N Olson
  • Gaelh Ouengue Mbele
  • Jonathan Doering
  • Lin Li
  • Gianina Ravenscroft

Detail Information

Publications52

  1. pmc Gastric hyperplasia in mice lacking the putative Cdc42 effector IQGAP1
    S Li
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Mol Cell Biol 20:697-701. 2000
    Human IQGAP1 is a widely expressed 190-kDa Cdc42-, Rac1-, and calmodulin-binding protein that interacts with F-actin in vivo and that can cross-link F-actin microfilaments in vitro...
  2. ncbi IQGAP1 promotes cell motility and invasion
    Jennifer M Mataraza
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School Boston, Massachusetts 02115, USA
    J Biol Chem 278:41237-45. 2003
    ..The scaffolding protein IQGAP1 binds to Cdc42, increasing the amount of active Cdc42 both in vitro and in cells...
  3. pmc IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase-driven tumors
    Katherine L Jameson
    Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA
    Nat Med 19:626-30. 2013
    ..MAPK scaffolds, such as IQ motif-containing GTPase activating protein 1 (IQGAP1), assemble pathway kinases to affect signal transmission, and disrupting scaffold function therefore offers an ..
  4. ncbi IQ-domain GTPase-activating protein 1 regulates beta-catenin at membrane ruffles and its role in macropinocytosis of N-cadherin and adenomatous polyposis coli
    Manisha Sharma
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, Westmead, New South Wales 2145, Australia
    J Biol Chem 282:8545-56. 2007
    ..Here we show that beta-catenin co-localizes with IQ-domain GTPase-activating protein 1 (IQGAP1), adenomatous polyposis coli (APC), and N-cadherin at actin-positive membrane ruffles in NIH 3T3 fibroblasts...
  5. pmc Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation
    Dominique T Brandt
    Institute of Pharmacology, University of Heidelberg, Heidelberg, Germany
    J Cell Biol 178:193-200. 2007
    ..In this study, we identify the cytoskeletal scaffold protein IQGAP1 as a Dia1-binding protein that is necessary for its subcellular location...
  6. pmc IQGAP1 modulates activation of B-Raf
    Jian Guo Ren
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:10465-9. 2007
    b>IQGAP1 modulates several cellular functions, including cell-cell adhesion, transcription, cytoskeletal architecture, and selected signaling pathways...
  7. pmc Gene expression of IQGAPs and Ras families in an experimental mouse model for hepatocellular carcinoma: a mechanistic study of cancer progression
    Khairy M A Zoheir
    Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University P O Box 2457, Riyadh, Saudi Arabia Department of Cell Biology, National Research Centre 12622 Cairo, Egypt
    Int J Clin Exp Pathol 8:8821-31. 2015
    ..The genetic expressions of IQGAP1, IQGAP2, IQGAP3, Hras, Kras, Nras, Mras, Caspase3, and BAX were followed in both hepatocellular carcinoma and ..
  8. pmc The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1
    Matthew J Smith
    Ontario Cancer Institute, MaRS TMDT, Toronto, Canada
    EMBO J 29:884-96. 2010
    ..Using mass spectrometry, we identified the multidomain scaffold IQGAP1 as a ShcA-interacting protein...
  9. pmc The scaffolding protein IQGAP1 co-localizes with actin at the cytoplasmic face of the nuclear envelope: implications for cytoskeletal regulation
    Michael A Johnson
    Westmead Institute for Cancer Research University of Sydney Westmead Millennium Institute at Westmead Hospital Westmead, Australia
    Bioarchitecture 2:138-42. 2012
    b>IQGAP1 is an important cytoskeletal regulator, known to act at the plasma membrane to bundle and cap actin filaments, and to tether the cortical actin meshwork to microtubules via plus-end binding proteins...
  10. pmc IQGAP1 links PDGF receptor-β signal to focal adhesions involved in vascular smooth muscle cell migration: role in neointimal formation after vascular injury
    Takashi Kohno
    Department of Pharmacology, Center for Lung and Vascular Biology, University of Illinois at Chicago, Chicago, Illinois
    Am J Physiol Cell Physiol 305:C591-600. 2013
    ..We previously identified IQ-domain GTPase-activating protein 1 (IQGAP1) as a novel VEGF receptor 2 binding scaffold protein involved in endothelial migration...
  11. doi IQGAP1 expression in spared CA1 neurons after an excitotoxic lesion in the mouse hippocampus
    Min Hee Yi
    Department of Anatomy, Brain Research Institute, Chungnam National University School of Medicine, Daejeon, 301 747, South Korea
    Cell Mol Neurobiol 33:1003-12. 2013
    ..IQ-domain GTPase-activating proteins (IQGAP1), is an effector of Rac1 and Cdc42 and an actin-binding protein, was upregulated in CA1 pyramidal neurons after ..
  12. pmc The Hippo signaling pathway is required for salivary gland development and its dysregulation is associated with Sjogren's syndrome
    Tone B Enger
    Department of Oral Surgery and Oral Medicine, University of Oslo, Oslo, Norway
    Lab Invest 93:1203-18. 2013
    ..Our studies show that Hippo signaling has a crucial role in SMG-branching morphogenesis and provide evidence that defects in this pathway are associated with SS in humans. ..
  13. pmc Activated Cdc42-bound IQGAP1 determines the cellular endocytic site
    Toshihide Kimura
    Department of Pharmacology, Oita University Faculty of Medicine, Hasama, Yufu, Oita, Japan
    Mol Cell Biol 33:4834-43. 2013
    ..In the present study, we identified IQGAP1 as a novel GDP-bound-Rab27a-interacting protein...
  14. pmc Bile acids activate YAP to promote liver carcinogenesis
    Sayeepriyadarshini Anakk
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, IL 61801, USA Electronic address
    Cell Rep 5:1060-9. 2013
    ..Bile acids act as upstream regulators of YAP via a pathway dependent on the induction of the scaffold protein IQGAP1. Patients with diverse biliary dysfunctions exhibit enhanced IQGAP1 and nuclear YAP expression...
  15. ncbi Rac-1 and IQGAP are potential regulators of E-cadherin-catenin interactions during murine preimplantation development
    David R Natale
    Department of Physiology and Pharmacology University of Western Ontario, Ontario, London, Canada N6A 5C1
    Gene Expr Patterns 2:17-22. 2002
    ..IQGAP-1 and rac-1 protein distribution changes from predominantly plasma membrane associated to predominantly cytoplasmic as the embryo progresses through cleavage divisions and compaction to the blastocyst stage...
  16. ncbi Rac-1 and IQGAP are potential regulators of E-cadherin-catenin interactions during murine preimplantation development
    David R Natale
    Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada N6A 5C1
    Mech Dev 119:S21-6. 2002
    ..IQGAP-1 and rac-1 protein distribution changes from predominantly plasma membrane associated to predominantly cytoplasmic as the embryo progresses through cleavage divisions and compaction to the blastocyst stage...
  17. pmc KLHL40 deficiency destabilizes thin filament proteins and promotes nemaline myopathy
    Ankit Garg
    J Clin Invest 124:3529-39. 2014
    ..Loss of sarcomere thin filament proteins is a frequent cause of NM; therefore, our data that KLHL40 stabilizes NEB and LMOD3 provide a potential basis for the development of NM in KLHL40-deficient patients. ..
  18. pmc EGFR controls IQGAP basolateral membrane localization and mitotic spindle orientation during epithelial morphogenesis
    Inmaculada Bañón-Rodríguez
    Centro de Biología Molecular Severo Ochoa Consejo Superior de Investigaciones Científicas CSIC, Madrid, Spain
    EMBO J 33:129-45. 2014
    ..we have used the 3D-MDCK model system to demonstrate a key role for a newly identified protein complex formed by IQGAP1 and the epithelial growth factor receptor (EGFR) in controlling the orientation of the mitotic spindle...
  19. pmc IQGAP1 is a key node within the small GTPase network
    Guillaume Jacquemet
    Wellcome Trust Centre for Cell Matrix Research Faculty of Life Sciences University of Manchester Manchester, UK
    Small Gtpases 4:199-207. 2013
    ..Specifically, we identify the scaffolding protein IQGAP1 as a master regulator of multiple small GTPases, including Cdc42, Rac1, Rap1, and RhoA...
  20. pmc Interaction of Moloney murine leukemia virus matrix protein with IQGAP
    Juliana Leung
    Integrated Program in Cellular, Molecular, and Biophysical Studies, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    EMBO J 25:2155-66. 2006
    The matrix protein (MA) of the Moloney murine leukemia virus (M-MuLV) was found to interact with IQGAP1, a prominent regulator of the cytoskeleton...
  21. doi IQGAP1 mediates angiotensin II-induced apoptosis of podocytes via the ERK1/2 MAPK signaling pathway
    Yipeng Liu
    Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan, China
    Am J Nephrol 38:430-44. 2013
    ..IQ domain GTPase-activating protein 1 (IQGAP1) is a scaffolding protein of the mitogen-activated protein kinases (MAPK) signaling pathway, and plays a ..
  22. pmc IQGAP1 suppresses TβRII-mediated myofibroblastic activation and metastatic growth in liver
    Chunsheng Liu
    GI Research Unit and Cancer Cell Biology Program, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Invest 123:1138-56. 2013
    ..Here, we demonstrate that IQ motif containing GTPase activating protein 1 (IQGAP1) binds to TGF-β receptor II (TβRII) and suppresses TβRII-mediated signaling in pericytes to prevent ..
  23. doi IQGAP1: A microtubule-microfilament scaffolding protein with multiple roles in nerve cell development and synaptic plasticity
    Ignacio Jausoro
    Laboratory of Neurobiology, Instituto Investigación Médica Mercedes y Martín Ferreyra INIMEC CONICET, Cordoba, Argentina
    Histol Histopathol 27:1385-94. 2012
    ..article, we review our current understanding of the biology of IQ domain-containing GTPase-Activating Protein 1, IQGAP1, a scaffolding protein with multiple binding partners, which is widely expressed among different cell types, ..
  24. pmc The cytoskeletal adaptor protein IQGAP1 regulates TCR-mediated signaling and filamentous actin dynamics
    Jacquelyn A Gorman
    Department of Immunology, Schulze Center for Novel Therapeutics, College of Medicine, Mayo Clinic, Rochester, MN 55901, USA
    J Immunol 188:6135-44. 2012
    The Ras GTPase-activating-like protein IQGAP1 is a multimodular scaffold that controls signaling and cytoskeletal regulation in fibroblasts and epithelial cells...
  25. pmc IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia
    M Bhattacharya
    Lung Biology Center, UCSF, Rock Hall, Rm 545, 1550 4th St, San Francisco, CA 94158, USA
    Am J Physiol Lung Cell Mol Physiol 303:L12-9. 2012
    ..we used mass spectrometric sequencing of integrin complexes to isolate the novel β(3)-integrin binding partner IQGAP1. Like integrin β(3), IQGAP1 localized to the endothelial cell-cell junction after sphingosine-1-phosphate (S1P) ..
  26. pmc IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold
    Miles J Dixon
    Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dow St, Dundee DD1 5EH, Scotland, United Kingdom
    J Biol Chem 287:22483-96. 2012
    ..This module is defined by a C-terminal 105-107 amino acid region of which IQGAP1 and -2, but not IQGAP3, binds preferentially to phosphatidylinositol 3,4,5-trisphosphate (PtdInsP(3))...
  27. doi DGKζ is involved in LPS-activated phagocytosis through IQGAP1/Rac1 pathway
    Masashi Okada
    Department of Anatomy and Cell Biology, Yamagata University School of Medicine, Yamagata 990 9585, Japan
    Biochem Biophys Res Commun 420:479-84. 2012
    ..In this study, we identified a small GTPase effector protein, IQGAP1, as a novel DGKζ-associated complex protein...
  28. pmc IQGAP1: a regulator of intracellular spacetime relativity
    Subramaniam Malarkannan
    Laboratory of Molecular Immunology and Immunotherapy, Blood Research Institute, Milwaukee, WI 53226, USA
    J Immunol 188:2057-63. 2012
    ..Among many, IQGAP1 is one of the essential scaffolding proteins that coordinate multiple signaling pathways...
  29. pmc Salmonella enterica serotype Typhimurium usurps the scaffold protein IQGAP1 to manipulate Rac1 and MAPK signalling
    Hugh Kim
    Department of Translational Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Biochem J 440:309-18. 2011
    ..However, the precise mechanisms by which Salmonella induces cytoskeletal changes remain undefined. IQGAP1 (IQ motif-containing GTPase-activating protein 1) is a scaffold protein that binds multiple proteins including ..
  30. pmc ERK1/2 activation in heart is controlled by melusin, focal adhesion kinase and the scaffold protein IQGAP1
    Mauro Sbroggiò
    Dipartimento di Genetica, Biologia e Biochimica, Universita di Torino, Molecular Biotechnology Center, Via Nizza, 52, 10126 Torino, Italy
    J Cell Sci 124:3515-24. 2011
    ..we demonstrate that both focal adhesion kinase (FAK) and IQ motif-containing GTPase activating protein 1 (IQGAP1), a scaffold protein for the ERK1/2 signalling cascade, are part of the melusin complex and are required for ERK1/..
  31. pmc IQGAP1 is involved in post-ischemic neovascularization by regulating angiogenesis and macrophage infiltration
    Norifumi Urao
    Department of Pharmacology, Center for Lung and Vascular Biology, Center for Cardiovascular Research, University of Illinois, Chicago, Illinois, United States of America
    PLoS ONE 5:e13440. 2010
    ..b>IQGAP1, an actin-binding scaffold protein, is a key regulator for actin cytoskeleton and motility...
  32. doi A dual role for IQGAP1 in regulating exocytosis
    Eric N Rittmeyer
    Department of Microbiology, Cornell University, Ithaca, NY 14853 2703, USA
    J Cell Sci 121:391-403. 2008
    ..been identified as a positional marker linking polarity and exocytosis cues, studies on its mammalian counterpart, IQGAP1, have focused on its role in organizing cytoskeletal architecture, for which the underlying mechanism is unclear...
  33. ncbi The zinc- and calcium-binding S100B interacts and co-localizes with IQGAP1 during dynamic rearrangement of cell membranes
    Gaelh Ouengue Mbele
    Département Réponse et Différenciation Cellulaires du Commissariat à l Energie Atomique CEA, INSERM EMI 0104 DRDC TS, Grenoble 38054, France
    J Biol Chem 277:49998-50007. 2002
    ..We have identified the IQGAP1 protein as the major cytoplasmic S100B target protein in different rat and human glial cell lines in the presence ..
  34. ncbi A shear-restricted pathway of platelet procoagulant activity is regulated by IQGAP1
    Wadie F Bahou
    Department of Medicine, State University of New York at Stony Brook, Stony Brook, New York 11794 8151, USA wbahou notes cc sunysb edu
    J Biol Chem 279:22571-7. 2004
    ..We describe a novel intracellular signaling mechanism involving platelet IQGAP1 that specifically regulates the development of platelet procoagulant activity under conditions of mechanical shear ..
  35. ncbi Distinct PAR/IQGAP expression patterns during murine development: implications for thrombin-associated cytoskeletal reorganization
    Lisa D Cupit
    Department of Medicine, State University of New York at Stony Brook, 11794 8151, USA
    Mamm Genome 15:618-29. 2004
    ..These data provide a panoramic survey of PAR/ IQGAP expression as an initial approach to dissect thrombin signaling pathways linked to cytoskeletal reorganization...
  36. ncbi Characterization of the interactions of the nephrin intracellular domain
    Xiao Li Liu
    Divisions of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    FEBS J 272:228-43. 2005
    ..Peptide mass fingerprinting and amino acid sequencing identified this protein as IQGAP1, an effector protein of small GTPases Rac1 and Cdc42 and a putative regulator of cell-cell adherens junctions...
  37. ncbi Calcium-dependent interaction of Lis1 with IQGAP1 and Cdc42 promotes neuronal motility
    Stanislav S Kholmanskikh
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021, USA
    Nat Neurosci 9:50-7. 2006
    ..Lis1 promotes Cdc42 activation through interaction with the calcium sensitive GTPase scaffolding protein IQGAP1, maintaining the perimembrane localization of IQGAP1 and CLIP170 and thereby tethering microtubule ends to the ..
  38. ncbi IQGAP1 regulates adult neural progenitors in vivo and vascular endothelial growth factor-triggered neural progenitor migration in vitro
    Laurent Balenci
    Institut National de la Sante et de la Recherche Medicale, Unité 873, Laboratoire Transduction du Signal, F 38054 Grenoble, France
    J Neurosci 27:4716-24. 2007
    ..In the present study, we report a modulating role for the scaffolding protein IQGAP1 in neural progenitor migration...
  39. pmc N-cadherin regulates cytoskeletally associated IQGAP1/ERK signaling and memory formation
    Christina Schrick
    Department of Psychiatry and Behavioral Sciences, The Asher Center for Depressive Disorders, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Neuron 55:786-98. 2007
    ..of a distinctive, cytoskeletally associated fraction of hippocampal Erk-1/2 and altered the distribution of IQGAP1, a scaffold protein linking cadherin-mediated cell adhesion to the cytoskeleton...
  40. pmc Development of hepatocellular carcinoma in Iqgap2-deficient mice is IQGAP1 dependent
    Valentina A Schmidt
    Division of Hematology, HSC T15, Rm 040, State University of New York at Stony Brook, Stony Brook, NY 11794 8151, USA
    Mol Cell Biol 28:1489-502. 2008
    ..age-dependent development of apoptosis and hepatocellular carcinoma (HCC), characterized by the overexpression of IQGAP1, the loss of membrane E-cadherin expression, the cytoplasmic translocation (and activation) of beta-catenin, and ..
  41. pmc Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex
    Sonia Sharma
    Department of Pathology, Harvard Medical School, Immune Disease Institute and Program in Cellular and Molecular Medicine, Children s Hospital Boston, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:11381-6. 2011
    ..Combined knockdown of NRON and IQGAP1 increased NFAT dephosphorylation and nuclear import exclusively after stimulation, without affecting the rate of ..
  42. pmc Site-specific expression of IQGAP1, a key mediator of cytoskeleton, in mouse renal tubules
    Li Wen Lai
    Department of Medicine, University of Arizona College of Medicine, PO BOX 245022, Tucson, AZ 85724, USA
    J Histochem Cytochem 56:659-66. 2008
    b>IQGAP1 is a multifunctional junction molecule that is involved in cell migration, proliferation, differentiation, cell polarity, and cell-cell adhesion...
  43. doi IQGAP1 integrates Ca2+/calmodulin and B-Raf signaling
    Jian Guo Ren
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 283:22972-82. 2008
    ..We previously documented that IQGAP1 is a scaffold in the MAPK cascade. IQGAP1 binds to and regulates the activities of ERK, MEK, and B-Raf...
  44. doi IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade
    Hisashi Nojima
    Laboratory of Biological Science, Graduate School of Frontier Biosciences Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    Nat Cell Biol 10:971-8. 2008
    ..Here we show that the IQGAP family, comprising IQGAP1, 2 and 3, underlies lateral cell-cell contacts of epithelial cells...
  45. doi Cdc42 protein acts upstream of IQGAP1 and regulates cytokinesis in mouse oocytes and embryos
    Anna Bielak-Zmijewska
    Department of Embryology, Institute of Zoology, University of Warsaw, Miecznikowa 1, 02 096 Warsaw, Poland
    Dev Biol 322:21-32. 2008
    Cdc42 and Rac1 Rho family GTPases, and their interacting protein IQGAP1 are the key regulators of cell polarity...
  46. pmc IQGAP1 regulates cell proliferation through a novel CDC42-mTOR pathway
    Jian Bin Wang
    Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA
    J Cell Sci 122:2024-33. 2009
    ..b>IQGAP1, an effector of CDC42 GTPase has been implicated in the modulation of cell architecture, regulation of exocytosis ..
  47. pmc Increased expression of angiogenic genes in the brains of mouse meg3-null embryos
    Francesca E Gordon
    Neuroendocrine Unit, Bulfinch 457B, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Endocrinology 151:2443-52. 2010
    ..In conclusion, Meg3 may play an important role in control of vascularization in the brain and may function as a tumor suppressor in part by inhibiting angiogenesis...
  48. pmc Rap1b facilitates NK cell functions via IQGAP1-mediated signalosomes
    Aradhana Awasthi
    Molecular Immunology, Blood Research Institute, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Exp Med 207:1923-38. 2010
    ..Upon activation, Rap1b colocalized with the scaffolding protein IQGAP1. This interaction facilitated sequential phosphorylation of B-Raf, C-Raf, and ERK1/2 and helped IQGAP1 to form a ..
  49. pmc IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload
    Mauro Sbroggiò
    Dipartimento di Genetica, Biologia e Biochimica, Molecular Biotechnology Center, Universita di Torino, Via Nizza 52, Turin, Italy
    Cardiovasc Res 91:456-64. 2011
    ..Here, we investigated the role of IQ motif-containing GTPase-activating protein 1 (IQGAP1), a scaffold for the ERK1/2 cascade, in heart function and remodelling in response to pressure overload.
  50. pmc IQGAP1 regulates NR2A signaling, spine density, and cognitive processes
    Can Gao
    Department of Psychiatry and Behavioral Sciences, The Asher Center for Study and Treatment of Depressive Disorders, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 31:8533-42. 2011
    ..Here we identify the scaffolding protein IQGAP1 as a key regulator of dendritic spine number with a specific role in cognitive but not emotional or motivational ..
  51. ncbi IQGAP1 binds Rap1 and modulates its activity
    Ha Won Jeong
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Biol Chem 282:20752-62. 2007
    b>IQGAP1 is a scaffolding protein involved in multiple fundamental cellular activities, including transcription, cell-cell attachment, and regulation of the cytoskeleton...

Research Grants3

  1. Molecular Mechanisms of Natural Killer Cell Activation
    Subramaniam Malarkannan; Fiscal Year: 2010
    ..Mechanisms identified here will not only have practical implications in tumor and graft immunity but will serve as models for other systems in which the responding cell must balance a number of activating and inhibitory inputs. ..
  2. MOLECULAR GENETICS OF PAR-3
    Lisa Cupit; Fiscal Year: 2004
    ..The candidate's long-term goal is the pursuit of a career in academic medicine. ..
  3. Role of IQGAP2 in platelet thrombin signaling
    VALENTINA SCHMIDT; Fiscal Year: 2004
    ..The candidate's long-term goal is the pursuit of a career in academic medical research. ..