Insr

Summary

Gene Symbol: Insr
Description: insulin receptor
Alias: 4932439J01Rik, CD220, D630014A15Rik, IR-A, IR-B, insulin receptor
Species: mouse

Top Publications

  1. ncbi Role of brain insulin receptor in control of body weight and reproduction
    J C Bruning
    Klinik II und Poliklinik für Innere Medizin and Center of Molecular Medicine ZMMK der Universität zu Köln, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    Science 289:2122-5. 2000
  2. pmc Role for neuronal insulin resistance in neurodegenerative diseases
    Markus Schubert
    Institute for Genetics, University of Cologne, D 50931 Cologne, Germany
    Proc Natl Acad Sci U S A 101:3100-5. 2004
  3. ncbi Early neonatal death in mice homozygous for a null allele of the insulin receptor gene
    D Accili
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 12:106-9. 1996
  4. ncbi Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes
    R N Kulkarni
    Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cell 96:329-39. 1999
  5. pmc Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality
    R L Joshi
    Institut Cochin de Genetique Moleculaire, INSERM U257, Paris, France
    EMBO J 15:1542-7. 1996
  6. ncbi Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles
    J C Bruning
    Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cell 88:561-72. 1997
  7. ncbi Growth-promoting interaction of IGF-II with the insulin receptor during mouse embryonic development
    A Louvi
    Department of Genetics and Development, Columbia University, New York, New York, 10032, USA
    Dev Biol 189:33-48. 1997
  8. ncbi Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue
    D Lauro
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 20:294-8. 1998
  9. ncbi A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance
    J C Bruning
    Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell 2:559-69. 1998
  10. pmc Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2
    Y Kido
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20842, USA
    J Clin Invest 105:199-205. 2000

Research Grants

  1. CONFERENCE ON DIABETES MELLITUS
    C Kahn; Fiscal Year: 2002
  2. ROLE OF MGRB10 IN IGF-I INDUCED SIGNALING
    Andrea Morrione; Fiscal Year: 2002
  3. INSULIN & GLUCOSE SIGNALING PATHWAYS IN ISLET BETA CELLS
    Rohit Kulkarni; Fiscal Year: 2004
  4. Leptin modulation of insulin action in the islet b-cell
    Rohit Kulkarni; Fiscal Year: 2005
  5. Dissecting the Death Pathway in Islet Beta Cells
    Rohit Kulkarni; Fiscal Year: 2005
  6. The Role of Egr-1 in GnRH Neurons
    Sara DiVall; Fiscal Year: 2005
  7. Role of Leptin in Islet Growth
    Rohit Kulkarni; Fiscal Year: 2008
  8. Proepithelin Signaling in Urothelial Cells
    Andrea Morrione; Fiscal Year: 2009
  9. MOUSE MODELS OF INSULIN RESISTANCE
    Domenico Accili; Fiscal Year: 2009
  10. Beta Cell Adaptation to Stress in Baboon Pancreas After Partial Pancreatectomy
    FRANCO BATTISTA FOLLI; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications127 found, 100 shown here

  1. ncbi Role of brain insulin receptor in control of body weight and reproduction
    J C Bruning
    Klinik II und Poliklinik für Innere Medizin and Center of Molecular Medicine ZMMK der Universität zu Köln, Joseph Stelzmann Strasse 9, 50931 Cologne, Germany
    Science 289:2122-5. 2000
    ..Thus, IR signaling in the CNS plays an important role in regulation of energy disposal, fuel metabolism, and reproduction...
  2. pmc Role for neuronal insulin resistance in neurodegenerative diseases
    Markus Schubert
    Institute for Genetics, University of Cologne, D 50931 Cologne, Germany
    Proc Natl Acad Sci U S A 101:3100-5. 2004
    ..contributes to defects in neuronal function, we have performed a detailed analysis of brain/neuron-specific insulin receptor knockout (NIRKO) mice...
  3. ncbi Early neonatal death in mice homozygous for a null allele of the insulin receptor gene
    D Accili
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 12:106-9. 1996
  4. ncbi Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes
    R N Kulkarni
    Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cell 96:329-39. 1999
    ..has a functional role in the beta cell we have used the Cre-loxP system to specifically inactivate the insulin receptor gene in the beta cells...
  5. pmc Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality
    R L Joshi
    Institut Cochin de Genetique Moleculaire, INSERM U257, Paris, France
    EMBO J 15:1542-7. 1996
    Targeted disruption of the insulin receptor gene (Insr) in the mouse was achieved using the homologous recombination approach. Insr+/- mice were normal as shown by glucose tolerance tests...
  6. ncbi Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles
    J C Bruning
    Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cell 88:561-72. 1997
    ..Mice double heterozygous for null alleles in the insulin receptor and insulin receptor substrate-1 genes exhibit the expected approximately 50% reduction in expression of ..
  7. ncbi Growth-promoting interaction of IGF-II with the insulin receptor during mouse embryonic development
    A Louvi
    Department of Genetics and Development, Columbia University, New York, New York, 10032, USA
    Dev Biol 189:33-48. 1997
    ..To determine whether XR is the insulin receptor (IR), we examined embryos nullizygous for both Igf1r and Insr...
  8. ncbi Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue
    D Lauro
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 20:294-8. 1998
    ..These findings indicate the need for a critical re-examination of the primary site(s) of insulin resistance in diabetes...
  9. ncbi A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance
    J C Bruning
    Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell 2:559-69. 1998
    ..muscle insulin resistance to the metabolic phenotype of diabetes, we used the Cre-loxP system to disrupt the insulin receptor gene in mouse skeletal muscle...
  10. pmc Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2
    Y Kido
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20842, USA
    J Clin Invest 105:199-205. 2000
    ..signaling pathway in these processes, we have generated mice with combined heterozygous null mutations in insulin receptor (ir), insulin receptor substrate (irs-1), and/or irs-2...
  11. pmc Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle
    J K Kim
    Department of Internal Medicine and the Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA
    J Clin Invest 105:1791-7. 2000
    ..Mice with muscle-specific inactivation of the insulin receptor gene (MIRKO) are normoglycemic but have increased fat mass...
  12. ncbi A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes
    F Mauvais-Jarvis
    Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes 49:2126-34. 2000
    ..We have previously reported that isolated insulin resistance in muscle by a tissue-specific insulin receptor knockout (MIRKO mouse) is not sufficient to alter glucose homeostasis, whereas beta-cell-specific insulin ..
  13. ncbi Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells
    B Leibiger
    The Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    Mol Cell 7:559-70. 2001
    ..Whereas insulin gene transcription is promoted by signaling through insulin receptor A type (Ex11-), PI3K class Ia, and p70s6k, insulin stimulates the betaGK gene by signaling via insulin ..
  14. pmc Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance
    C Guerra
    Jackson Laboratory, Bar Harbor, Minnesota, USA
    J Clin Invest 108:1205-13. 2001
    ..Recombination technology using the Cre-loxP approach allows inactivation of the insulin receptor in a tissue-specific manner...
  15. pmc Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression
    Darrell D Belke
    Department of Pharmacology and Therapeutics, University of Calgary, Calgary, Alberta, Canada
    J Clin Invest 109:629-39. 2002
    ..cardiac development, physiology, and cardiac metabolism, we generated mice with a cardiomyocyte-selective insulin receptor knockout (CIRKO) using cre/loxP recombination...
  16. ncbi The insulin receptor catalyzes the tyrosine phosphorylation of caveolin-1
    Akiko Kimura
    Department of Medicine, Life Sciences Institute, University of Michigan School of Medicine, Ann Arbor, Michigan 48109 0650, USA
    J Biol Chem 277:30153-8. 2002
    ..To explore the mechanisms involved in this event, we evaluated the association of the insulin receptor with caveolin...
  17. ncbi Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance
    Matthias Bluher
    Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Dev Cell 3:25-38. 2002
    ..Using the Cre-loxP system, we created mice with fat-specific disruption of the insulin receptor gene (FIRKO mice)...
  18. ncbi Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1
    Jun Nakae
    Naomi Berrie Diabetes Center, Berrie Research Pavilion, 1150 St Nicholas Avenue, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Nat Genet 32:245-53. 2002
    ..This has been corrected in the full-text online version of the article. The name will appear correctly in the print version...
  19. pmc The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth
    Tadahiro Kitamura
    Naomi Berrie Diabetes Center, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York, USA
    J Clin Invest 110:1839-47. 2002
    ..Mice lacking insulin receptor substrate-2 (Irs2) develop beta cell failure, suggesting that insulin signaling is required to maintain an ..
  20. pmc The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance
    David Vicent
    Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 111:1373-80. 2003
    ....
  21. pmc Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization
    Tatsuya Kondo
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 111:1835-42. 2003
    ..the oxygen-induced retinopathy model to study mice with a vascular endothelial cell-specific knockout of the insulin receptor (VENIRKO) or IGF-1 receptor (VENIFARKO)...
  22. ncbi Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice
    Kenichi Otani
    Department of Medicine, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8066, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 286:E41-9. 2004
    Pancreatic beta-cell-restricted knockout of the insulin receptor results in hyperglycemia due to impaired insulin secretion, suggesting that this cell is an important target of insulin action...
  23. ncbi Testis determination requires insulin receptor family function in mice
    Serge Nef
    Center for Developmental Biology, University of Texas, Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390 9133, USA
    Nature 426:291-5. 2003
    ..Here we show that the insulin receptor tyrosine kinase family, comprising Ir, Igf1r and Irr, is required for the appearance of male gonads and thus ..
  24. pmc Mosaic analysis of insulin receptor function
    Tadahiro Kitamura
    Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    J Clin Invest 113:209-19. 2004
    ..Targeted ablation of insulin receptor (Insr) has not clarified this issue, because of early postnatal lethality...
  25. pmc The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
    Laura S Harrington
    Cancer Research UK Centre for Cell and Molecular Biology, The Institute of Cancer Research, 237 Fulham Rd, London SW3 6JB, England, UK
    J Cell Biol 166:213-23. 2004
    ..maintains insulin signaling to PI3K by restraining the activity of S6K, which when activated inactivates insulin receptor substrate (IRS) function, via repression of IRS-1 gene expression and via direct phosphorylation of IRS-1...
  26. pmc PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance
    Rohit N Kulkarni
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 114:828-36. 2004
    ..Here we show that the compensatory islet-growth response to insulin resistance in 2 models--insulin receptor (IR)/IR substrate-1 (IRS-1) double heterozygous mice and liver-specific IR KO (LIRKO) mice--is severely ..
  27. ncbi Preserved glucoregulation but attenuation of the vascular actions of insulin in mice heterozygous for knockout of the insulin receptor
    Stephen B Wheatcroft
    Department of Cardiology, Guy s King s and St Thomas School of Medicine, King s College London, Bessemer Road, London SE5 9PJ, UK
    Diabetes 53:2645-52. 2004
    ..We studied this relationship in mice heterozygous for knockout of the insulin receptor (IRKO), which have a mild perturbation of insulin signaling...
  28. ncbi Insulin signaling in the central nervous system is critical for the normal sympathoadrenal response to hypoglycemia
    Simon J Fisher
    Reserach Division, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Diabetes 54:1447-51. 2005
    ..system in regulating the counterregulatory response to hypoglycemia, mice with a brain/neuron-specific insulin receptor knockout (NIRKO) and littermate controls were subjected to 90-min hyperinsulinemic (20 mU x kg(-1) x min(-1)) ..
  29. pmc Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action
    Haruka Okamoto
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Clin Invest 115:1314-22. 2005
    Partial restoration of insulin receptor Insr expression in brain, liver, and pancreatic beta cells is sufficient for rescuing Insr knockout mice from neonatal death, preventing diabetes ketoacidosis, and normalizing life span and ..
  30. pmc Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis
    Julia Baumgartl
    Institute for Genetics, University of Cologne and Center of Molecular Medicine Cologne, D 50931 Cologne, Germany
    Cell Metab 3:247-56. 2006
    ..in the development of atherosclerosis, we have created mice with myeloid lineage-specific inactivation of the insulin receptor gene. On an ApoE-deficient background, MphIRKO mice developed smaller atherosclerotic lesions...
  31. ncbi Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions
    Seongah Han
    Department of Medicine, Columbia University, New York, New York 10032, USA
    Cell Metab 3:257-66. 2006
    ..signaling in macrophage foam cells might worsen atherosclerosis, Ldlr(-/-) mice were transplanted with insulin receptor Insr(+/+) or Insr(-/-) bone marrow...
  32. ncbi Role of hepatic STAT3 in brain-insulin action on hepatic glucose production
    Hiroshi Inoue
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Cell Metab 3:267-75. 2006
    ..These results thus indicate that IL-6-STAT3 signaling in the liver contributes to insulin action in the brain, leading to the suppression of hepatic glucose production...
  33. ncbi Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes
    Kohjiro Ueki
    Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Genet 38:583-8. 2006
    ..We propose that therapeutic improvement of insulin and IGF-I signaling in beta cells might protect against type 2 diabetes...
  34. pmc Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance
    Terumasa Okada
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 104:8977-82. 2007
    ..In the first model, we used liver-specific insulin receptor knockout (LIRKO) mice, which exhibit hyperinsulinemia without developing diabetes due to a compensatory ..
  35. ncbi Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production
    A Christine Könner
    Department of Mouse Genetics and Metabolism, Institute for Genetics, Center for Molecular Medicine, University of Cologne, D 50674 Cologne, Germany
    Cell Metab 5:438-49. 2007
    ..insulin-responsive neurons that mediate these effects, we generated mice with selective inactivation of the insulin receptor (IR) in either pro-opiomelanocortin (POMC)- or agouti-related peptide (AgRP)-expressing neurons of the ..
  36. pmc Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance
    Kazuya Kabayama
    Division of Glycopathology, Institute of Molecular Biomembranes and Glycobiology, Tohoku Pharmaceutical University, 4 4 1, Komatsushima, Sendai 981 8558, Miyagi, Japan
    Proc Natl Acad Sci U S A 104:13678-83. 2007
    ....
  37. ncbi Accelerated endothelial dysfunction in mild prediabetic insulin resistance: the early role of reactive oxygen species
    Edward R Duncan
    The Cardiovascular Division, King s College London School of Medicine, King s College London, London, UK
    Am J Physiol Endocrinol Metab 293:E1311-9. 2007
    ..Mice with haploinsufficiency for the insulin receptor (IRKO) are a model of mild insulin resistance with preserved glycemic control...
  38. ncbi Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver
    Michihiro Matsumoto
    Naomi Berrie Diabetes Center, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Cell Metab 6:208-16. 2007
    ..caused by generalized ablation of insulin receptors and prevents neonatal diabetes and hepatosteatosis in insulin receptor knockout mice...
  39. pmc Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis
    Sudha B Biddinger
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Cell Metab 7:125-34. 2008
    ..Liver insulin receptor knockout (LIRKO) mice have pure hepatic insulin resistance...
  40. pmc Epidermal insulin/IGF-1 signalling control interfollicular morphogenesis and proliferative potential through Rac activation
    Heike Stachelscheid
    Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany
    EMBO J 27:2091-101. 2008
    ..Our results identify the small GTPase Rac as a key target of epidermal IR/IGF-1R signalling crucial for proliferative potential and interfollicular morphogenesis...
  41. pmc New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
    Yu Hua Tseng
    Section on Obesity and Hormone Action, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 454:1000-4. 2008
    ..These data reveal an important role of BMP7 in promoting brown adipocyte differentiation and thermogenesis in vivo and in vitro, and provide a potential new therapeutic approach for the treatment of obesity...
  42. pmc Diabetes reduces autophosphorylation of retinal insulin receptor and increases protein-tyrosine phosphatase-1B activity
    Raju V S Rajala
    Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Invest Ophthalmol Vis Sci 50:1033-40. 2009
    ..The expression, activity, and functional role of PTP1B in the retina are unknown. In this study, the authors examined the relationship between the retinal insulin receptor (IR) and PTP1B in normal and diabetic mouse retinas.
  43. pmc Insulin signaling in alpha cells modulates glucagon secretion in vivo
    Dan Kawamori
    Department of Cellular and Molecular Physiology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Cell Metab 9:350-61. 2009
    ..In this study, we created and characterized alpha cell-specific insulin receptor knockout (alphaIRKO) mice to directly explore the role of insulin signaling in the regulation of glucagon ..
  44. doi Insulin receptor and IGF1R are not required for oocyte growth, differentiation, and maturation in mice
    J L Pitetti
    Department of Genetic Medicine and Development, University of Geneva Medical School, University of Geneva, CH 1211 Geneva 4, Switzerland
    Sex Dev 3:264-72. 2009
    ..and insulin-like growth factors (IGFs: IGF1 and IGF2) act through 2 structurally related receptors, the insulin receptor (INSR) and the type 1 IGF receptor (IGF1R), both of which are expressed in developing oocytes...
  45. pmc Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons
    Hua V Lin
    Department of Medicine, Columbia University, New York, New York, USA
    Diabetes 59:337-46. 2010
    ..We have shown that mice with hypothalamic deficiency (L1) of insulin receptors (InsRs) fail to regulate hepatic glucose production (HGP) in response to insulin...
  46. pmc Insulin signaling regulates mitochondrial function in pancreatic beta-cells
    Siming Liu
    Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 4:e7983. 2009
    ..Mitochondria isolated from beta-cells derived from beta-cell specific insulin receptor knockout (betaIRKO) mice exhibited reduced BAD(S), GK and protein kinase A in the complex, and attenuated ..
  47. pmc Enhanced retinal insulin receptor-activated neuroprotective survival signal in mice lacking the protein-tyrosine phosphatase-1B gene
    Raju V S Rajala
    Department of Ophthalmology, Dean A McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 285:8894-904. 2010
    ..We previously demonstrated that light-induced tyrosine phosphorylation of the retinal insulin receptor (IR) results in the activation of phosphoinositide 3-kinase/Akt survival pathway in rod photoreceptor cells...
  48. pmc Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility
    Jennifer W Hill
    Center for Diabetes and Endocrine Research, Department of Physiology and Pharmacology, College of Medicine, The University of Toledo, Toledo, OH 43614, USA
    Cell Metab 11:286-97. 2010
    ..We conclude that direct action of insulin and leptin on POMC neurons is required to maintain normal glucose homeostasis and reproductive function...
  49. pmc Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism
    Mathieu Ferron
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Cell 142:296-308. 2010
    The broad expression of the insulin receptor suggests that the spectrum of insulin function has not been fully described...
  50. pmc Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition
    Keertik Fulzele
    Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 142:309-19. 2010
    ..Here, we show that insulin receptor (IR) signaling in osteoblasts controls osteoblast development and osteocalcin expression by suppressing the ..
  51. pmc Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor
    Kathryn J Brothers
    Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Cell Metab 12:295-305. 2010
    ..By contrast, both lean and obese mice with a pituitary-specific knockout of the insulin receptor (PitIRKO) exhibited reproductive competency, indicating that insulin signaling in the pituitary is required ..
  52. pmc Insulin signaling to the glomerular podocyte is critical for normal kidney function
    Gavin I Welsh
    Academic Renal Unit, School of Clinical Sciences, University of Bristol, Bristol BS8 1TH, UK
    Cell Metab 12:329-40. 2010
    ..signaling in podocytes affects glomerular function in vivo, we generated mice with specific deletion of the insulin receptor from their podocytes...
  53. pmc A kinase-independent role for unoccupied insulin and IGF-1 receptors in the control of apoptosis
    Jeremie Boucher
    Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Sci Signal 3:ra87. 2010
    ..Insulin and IGF-1 binding stimulates receptor tyrosine kinase activity and blocks apoptosis, whereas unliganded IR and IGF1R, acting through a mechanism independent of their catalytic activity, exert a permissive effect on cell death...
  54. pmc Reproductive tissues maintain insulin sensitivity in diet-induced obesity
    Sheng Wu
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Diabetes 61:114-23. 2012
    ..Pituitary-specific insulin receptor knockout mice were used as controls...
  55. doi Dissociation of the insulin receptor from caveolae during TNFα-induced insulin resistance and its recovery by D-PDMP
    Junji Sekimoto
    Division of Glycopathology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Pharmaceutical University, 4 4 1, Komatsushima, Aoba ku, Sendai 981 8558, Miyagi, Japan
    FEBS Lett 586:191-5. 2012
    ..Here, we analyzed the interaction between insulin receptor (IR) and GM3 in the plasma membranes using immunoelectron microscopy...
  56. pmc Delayed puberty but normal fertility in mice with selective deletion of insulin receptors from Kiss1 cells
    Xiaoliang Qiu
    Center for Diabetes and Endocrine Research, University of Toledo College of Medicine, Toledo, OH 43614, USA
    Endocrinology 154:1337-48. 2013
    ..These data suggest that impaired insulin sensing by Kiss1 neurons delays the initiation of puberty but does not affect adult fertility. These studies provide insight into the mechanisms regulating pubertal timing in anabolic states...
  57. pmc Insulin receptor signaling in cones
    Ammaji Rajala
    Department of Ophthalmology, University of Oklahoma Health Sciences Center and Dean A McGee Eye Institute, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 288:19503-15. 2013
    ..To date there are no studies on the insulin receptor signaling in cones; however, mRNA levels of IR signaling proteins are significantly higher in cone-dominant ..
  58. ncbi Adiponectin resistance exacerbates insulin resistance in insulin receptor transgenic/knockout mice
    Hua V Lin
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Diabetes 56:1969-76. 2007
    ..Adiponectin increases insulin sensitivity and contributes to insulin's indirect effects on hepatic glucose production...
  59. ncbi Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
    M D Michael
    Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Mol Cell 6:87-97. 2000
    ..the effect of the loss of direct insulin action in liver, we have used the Cre-loxP system to inactivate the insulin receptor gene in hepatocytes...
  60. pmc Insulin signaling is required for insulin's direct and indirect action on hepatic glucose production
    Simon J Fisher
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston Massachusetts 02215, USA
    J Clin Invest 111:463-8. 2003
    ..we performed high-dose hyperinsulinemic-euglycemic clamps using [3-(3)H]-glucose in liver-specific insulin receptor knockout (LIRKO) mice, LIRKO mice treated with streptozotocin (LIRKO+STZ), and controls...
  61. ncbi Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice
    Rohit N Kulkarni
    Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetes 52:1528-34. 2003
    ..in a genetically susceptible host, we generated mice that are double heterozygous (DH) for knockout of the insulin receptor and insulin receptor substrate-1 on three genetic backgrounds (C57BL/6 [B6], 129Sv, and DBA)...
  62. pmc Transgenic rescue of insulin receptor-deficient mice
    Haruka Okamoto
    Department of Medicine, Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Clin Invest 114:214-23. 2004
    ..We show that combined restoration of insulin receptor function in brain, liver, and pancreatic beta cells rescues insulin receptor knockout mice from neonatal ..
  63. doi Age-related insulin resistance in hypothalamus and peripheral tissues of orexin knockout mice
    H Tsuneki
    Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Diabetologia 51:657-67. 2008
    ..The aim of this study was to reveal the role of orexin in the regulation of insulin sensitivity for glucose metabolism...
  64. pmc Central insulin action regulates peripheral glucose and fat metabolism in mice
    Linda Koch
    Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne, and Center of Molecular Medicine Cologne, Cologne, Germany
    J Clin Invest 118:2132-47. 2008
    ..These studies demonstrate that central insulin action plays an important role in regulating WAT mass and glucose metabolism via hepatic Stat3 activation...
  65. pmc Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart
    Sihem Boudina
    University of Utah School of Medicine, Salt Lake City, 84112, USA
    Circulation 119:1272-83. 2009
    ..The present study tested the hypothesis that perinatal loss of insulin signaling in the heart impairs mitochondrial function...
  66. pmc Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2
    Anke Assmann
    Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Mol Cell Biol 29:3219-28. 2009
    ..of exogenous glucose or insulin in beta-cell lines completely lacking either insulin receptors (betaIRKO) or insulin receptor substrate 2 (betaIRS2KO)...
  67. pmc Divergent roles of growth factors in the GnRH regulation of puberty in mice
    Sara A DiVall
    Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland 21212, USA
    J Clin Invest 120:2900-9. 2010
    ..These studies define the role of IGF-1R signaling in the coordination of somatic development with reproductive maturation and provide insight into the mechanisms regulating pubertal timing in anabolic states...
  68. pmc Activation of cannabinoid receptor type 1 (Cb1r) disrupts hepatic insulin receptor signaling via cyclic AMP-response element-binding protein H (Crebh)-mediated induction of Lipin1 gene
    Dipanjan Chanda
    National Creative Research Initiatives Center for Nuclear Receptor Signals, Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju 500 757, Republic of Korea
    J Biol Chem 287:38041-9. 2012
    ..in inducing phosphatidic acid phosphatase Lipin1 gene expression and subsequently deregulating hepatic insulin receptor signaling...
  69. pmc Lessons on conditional gene targeting in mouse adipose tissue
    Kevin Y Lee
    Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 62:864-74. 2013
    ..Thus, different "adipocyte-specific" Cre lines display different degrees of efficiency and specificity, illustrating important differences that must be taken into account in their use for studying adipose biology...
  70. ncbi Chromosome assignment of mouse insulin, colony stimulating factor 1, and low-density lipoprotein receptors
    L M Wang
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284
    Genomics 3:172-6. 1988
    ..Complementary DNA clones for Insr, Ldlr, and Csfmr were used to chromosomally assign the three genes in mouse...
  71. ncbi TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development
    A P Vicari
    DNAX Research Institute, Palo Alto, California 94304 1104, USA
    Immunity 7:291-301. 1997
    ..We conclude that TECK represents a novel thymic dendritic cell-specific CC chemokine that is possibly involved in T cell development...
  72. ncbi Improved metabolic disorders of insulin receptor-deficient mice by transgenic overexpression of glucokinase in the liver
    M Jackerott
    Department of Genetics, Development and Molecular Pathology, Cochin Institute, INSERM, CNRS, University of René Decartes, Paris, France
    Diabetologia 45:1292-7. 2002
    b>Insulin receptor null mutant mice develop severe diabetes, ketoacidosis and liver steatosis and die within 1 week after birth...
  73. ncbi Genetic mouse models of extended lifespan
    Hanyu Liang
    Department of Physiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MSC 7762, San Antonio, TX 78229 3900, USA
    Exp Gerontol 38:1353-64. 2003
    ..or p66(shc) (p66(shc-/-)), mice heterozygous for the IGF-I receptor (Igf1r(+/-)), and fat-specific insulin receptor knockout mice...
  74. ncbi Role of insulin action and cell size on protein expression patterns in adipocytes
    Matthias Bluher
    Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 279:31902-9. 2004
    Mice with a fat-specific insulin receptor knock-out (FIRKO) exhibit a polarization of white adipose tissue into two populations of cells, one small (diameter <50 microm) and one large (diameter >100 microm), accompanied by changes ..
  75. pmc Electrophysiological and behavioral phenotype of insulin receptor defective mice
    P Das
    Department of Biological Science, Programs in Neuroscience and Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA
    Physiol Behav 86:287-96. 2005
    ..A high level of expression of the concomitant insulin receptor (IR) kinase is also retained in this brain region, even in the adult...
  76. ncbi Essential role of PSM/SH2-B variants in insulin receptor catalytic activation and the resulting cellular responses
    Manchao Zhang
    Department of Biochemistry, West Virginia University, School of Medicine, Morgantown, WV 26506 9142, USA
    J Cell Biochem 103:162-81. 2008
    ..Potentiation of the insulin response originated at the insulin receptor (IR) kinase level by PSM variant-specific regulation of the Km (ATP) whereas the Vmax remained unaffected...
  77. ncbi Insulin signaling in mouse oocytes
    Nicole Acevedo
    Reproductive Sciences Program, University of Michigan, Ann Arbor, Michigan 48109, USA
    Biol Reprod 77:872-9. 2007
    ..and immunocytochemical analyses of germinal vesicle-intact (GVI) oocytes demonstrated the presence of insulin receptor-beta...
  78. ncbi Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway
    Matthew Townsend
    Department of Neurology, Harvard Medical School and Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 282:33305-12. 2007
    ..An antagonist of the insulin receptor family of tyrosine kinases was found to mimic the pattern of Abeta-mediated kinase inhibition...
  79. ncbi DM1 CTG expansions affect insulin receptor isoforms expression in various tissues of transgenic mice
    Céline Guiraud-Dogan
    INSERM, U781, Hopital Necker Enfants Malades, Universite Rene Descartes Paris V, 149 rue de Sevres, 75743 Paris Cedex 15, France
    Biochim Biophys Acta 1772:1183-91. 2007
    ..In particular, Insulin Receptor (IR) mRNA splicing defects have been observed in the muscle of DM1 patients...
  80. pmc A model for obesity and gigantism due to disruption of the Ankrd26 gene
    Tapan K Bera
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4264, USA
    Proc Natl Acad Sci U S A 105:270-5. 2008
    ..These results show that alterations in an unidentified gene can lead to obesity and identify a molecular target for the treatment of obesity...
  81. doi Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice
    Isabel Lastres-Becker
    Department of Neurology, J W Goethe University Medical School, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany
    Hum Mol Genet 17:1465-81. 2008
    ..This was associated with reduced insulin receptor expression in liver and cerebellum, although the mRNA levels were increased indicating a post-transcriptional ..
  82. pmc Liver-specific loss of lipolysis-stimulated lipoprotein receptor triggers systemic hyperlipidemia in mice
    Prachiti Narvekar
    Emmy Noether and Marie Curie Research Group Molecular Metabolic Control, DKFZ ZMBH Alliance, German Cancer Research Center Heidelberg, Heidelberg, Germany
    Diabetes 58:1040-9. 2009
    ..As hypertriglyceridemia has been identified as an important risk factor for cardiovascular complications, in this study we aimed to identify molecular mechanisms in aberrant triglyceride elevation under these conditions...
  83. doi Selective response to insulin versus insulin-like growth factor-I and -II and up-regulation of insulin receptor splice variant B in the differentiated mouse mammary epithelium
    Chiara Berlato
    Division of Medical Biochemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    Endocrinology 150:2924-33. 2009
    ..However, our analysis of the expression levels of IGF-IR and the two insulin receptor (IR) splice variants, IR-A and IR-B, has revealed a 3- to 4-fold up-regulation of IR-B transcripts and a 6-..
  84. pmc Hepatic insulin signaling regulates VLDL secretion and atherogenesis in mice
    Seongah Han
    Division of Molecular Medicine, Department of Medicine, Columbia University, 630 West 168th St, New York, New York 10032, USA
    J Clin Invest 119:1029-41. 2009
    ..These findings suggest a dual action of hepatic IR on lipoprotein levels, in which the ability to increase VLDL apoB and lipid secretion via AKT/GSK is offset by upregulation of Ldlr...
  85. pmc Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure
    J David Symons
    College of Health, University of Utah School of Medicine, 30 N 2030 E, Salt Lake City, UT 84132, USA
    Circ Res 104:1085-94. 2009
    ....
  86. pmc Cardiac expression of microsomal triglyceride transfer protein is increased in obesity and serves to attenuate cardiac triglyceride accumulation
    Emil D Bartels
    Department of Clinical Biochemistry, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
    PLoS ONE 4:e5300. 2009
    ..Nevertheless, the data suggest that genetically increased lipoprotein secretion prevents development of obesity-induced lipotoxic heart disease...
  87. pmc Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}
    Wei Qin Zhao
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Biol Chem 284:18742-53. 2009
    ..In contrast, transfection of malfunctioning human insulin receptor mutants, identified originally from patient with insulin resistance syndrome, or inhibition of insulin and ..
  88. pmc Growth factor receptor-bound protein 14 undergoes light-dependent intracellular translocation in rod photoreceptors: functional role in retinal insulin receptor activation
    Ammaji Rajala
    Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma73104, USA
    Biochemistry 48:5563-72. 2009
    ..We previously hypothesized that Grb14 protects light-dependent insulin receptor (IR) activation in rod photoreceptors against dephosphorylation by protein tyrosine phosphatase 1B...
  89. pmc Insulin receptor signaling regulates actin cytoskeletal organization in developing photoreceptors
    Raju V S Rajala
    Departments of Ophthalmology, University of Oklahoma Health Sciences Center, 608 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
    J Neurochem 110:1648-60. 2009
    The insulin receptor (IR) and IR signaling proteins are widely distributed throughout the CNS...
  90. pmc Insulin and insulin-like growth factor-1 receptors act as ligand-specific amplitude modulators of a common pathway regulating gene transcription
    Jeremie Boucher
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Biol Chem 285:17235-45. 2010
    ..before and after differentiation into adipocytes that express both receptors, but at different ratios; 2) insulin receptor (IR) or IGF1R knock-out preadipocytes that only express the complimentary receptor; and 3) IR/IGF1R double ..
  91. pmc Cannabinoids inhibit insulin receptor signaling in pancreatic β-cells
    Wook Kim
    National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    Diabetes 60:1198-209. 2011
    ..Insulin itself positively regulates β-cell proliferation in an autocrine manner through the insulin receptor (IR) signaling pathway...
  92. pmc IGF signaling directs ventricular cardiomyocyte proliferation during embryonic heart development
    Peng Li
    Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California Keck School of Medicine, Los Angeles, CA 90089, USA
    Development 138:1795-805. 2011
    ..Global disruption of the Igf2 gene, or conditional disruption of the two IGF receptor genes Igf1r and Insr together in the myocardium, each resulted in a significant decrease in ventricular wall proliferation and in ..
  93. pmc Organ-specific defects in insulin-like growth factor and insulin receptor signaling in late gestational asymmetric intrauterine growth restriction in Cited1 mutant mice
    Tatiana Novitskaya
    Division of Nephrology, Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
    Endocrinology 152:2503-16. 2011
    ..receptor (pIGF-IR) in the kidney, whereas reduced IGF-II is associated with decreased phosphorylation of the insulin receptor (pIR) in the lung. In contrast, decreased pIR is associated with reduced IGF-I but not IGF-II in the liver...
  94. ncbi Localization of growth arrest-specific genes on mouse chromosomes 1, 7, 8, 11, 13, and 16
    M P Colombo
    Division of Experimental Oncology D, Istituto Nazionali Tumori, Milano, Italy
    Mamm Genome 2:130-4. 1992
    ..The six genes are unlinked. Gas-1 maps to Chromosome (Chr) 13, Gas-2 to Chr 7, Gas-3 to Chr 11, Gas-4 to Chr 16, Gas-6 to Chr 8, and Gas-10 to Chr 1...
  95. ncbi An interspecific backcross linkage map of mouse chromosome 8
    J D Ceci
    Mammalian Genetics Laboratory, NCI Frederick Cancer Research Facility, Maryland 21701
    Genomics 6:72-9. 1990
    ..Genes that were mapped in this study include Act-6, Aprt, Aprt-ps1, Emv-2, Es-N, Hp, Insr, Mt-1, Plat, Psx-8, Ucp, and Zfp-4...
  96. ncbi Substrate phosphorylation catalyzed by the insulin receptor tyrosine kinase. Kinetic correlation to autophosphorylation of specific sites in the beta subunit
    J R Flores-Riveros
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    J Biol Chem 264:21557-72. 1989
    The kinetics of insulin-stimulated autophosphorylation of specific tyrosines in the beta subunit of the mouse insulin receptor and activation of receptor kinase-catalyzed phosphorylation of a model substrate were compared...
  97. ncbi Chromosomal mapping of the gene for the type II insulin-like growth factor receptor/cation-independent mannose 6-phosphate receptor in man and mouse
    G Laureys
    Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06510
    Genomics 3:224-9. 1988
    ..The CIM6PR/IGF2R locus in man is asyntenic with the genes encoding IGF-II (IGF2), the IGF-I receptor (IGF1R), and the cation-dependent mannose 6-phosphate receptor (CDM6PR)...
  98. ncbi The insulin receptor content is increased in breast cancers initiated by three different oncogenes in transgenic mice
    L Frittitta
    Istituto di Medicina Interna, Endocrinologia e Malattie del Metabolismo, Universita di Catania, Ospedale Garibaldi, Italy
    Breast Cancer Res Treat 45:141-7. 1997
    The Insulin Receptor (IR) is a potential oncogene for mammary epithelial cells since its content is increased in most human breast cancer specimens, and both ligand-dependent malignant transformation and ligand-dependent enhanced growth ..
  99. ncbi Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity
    Z Wu
    Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Mol Cell 3:151-8. 1999
    ..glucose transport, secondary to reduced gene expression and tyrosine phosphorylation for the insulin receptor and IRS-1...
  100. ncbi Identification of the APS protein as a novel insulin receptor substrate
    S A Moodie
    Metabolex, Inc, Hayward, California 94545, USA
    J Biol Chem 274:11186-93. 1999
    In order to identify novel substrates involved in insulin receptor signaling, a yeast two-hybrid 3T3-L1 adipocyte cDNA library was screened with the cytoplasmic domain of the human insulin receptor as bait...
  101. ncbi Deconstructing type 2 diabetes
    S I Taylor
    Diabetes Branch, Division of Intramural Research, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell 97:9-12. 1999

Research Grants15

  1. CONFERENCE ON DIABETES MELLITUS
    C Kahn; Fiscal Year: 2002
    ..Keystone conferences on diabetes have been held every 2-3 years, and have had increasing registration approaching 600 people (when combined with the obesity conference). ..
  2. ROLE OF MGRB10 IN IGF-I INDUCED SIGNALING
    Andrea Morrione; Fiscal Year: 2002
    ..but not insulin-induced mitogenesis in mouse embryo fibroblasts over-expressing either the IGF-IR or the insulin receptor (IR)...
  3. INSULIN & GLUCOSE SIGNALING PATHWAYS IN ISLET BETA CELLS
    Rohit Kulkarni; Fiscal Year: 2004
    ..Thus, normal beta-cells show glucose-stimulated phosphorylation of the insulin receptor (IR) and insulin receptor substrate-1 (IRS-1)...
  4. Leptin modulation of insulin action in the islet b-cell
    Rohit Kulkarni; Fiscal Year: 2005
    ..abstract_text> ..
  5. Dissecting the Death Pathway in Islet Beta Cells
    Rohit Kulkarni; Fiscal Year: 2005
    ..hypothesis we propose to use a model of beta-cell IGF deficiency for our studies - the beta-cell-specific insulin receptor and IGF-1 receptor double knockout mouse, (betaDKO), that exhibits enhanced beta-cell apoptosis during the ..
  6. The Role of Egr-1 in GnRH Neurons
    Sara DiVall; Fiscal Year: 2005
    ..Protein-DNA binding studies will be performed on candidate regions of the GnRH promoter. This could define a link between nutritional status and reproductive competency at a molecular level. ..
  7. Role of Leptin in Islet Growth
    Rohit Kulkarni; Fiscal Year: 2008
    ..The proposed studies are aimed at the long-term goal of developing therapeutic strategies to prevent or delay the development of diabetes in obese individuals. [unreadable] [unreadable] [unreadable]..
  8. Proepithelin Signaling in Urothelial Cells
    Andrea Morrione; Fiscal Year: 2009
    ..Furthermore, the identification of novel proteins and novel mechanism(s) that regulate proepithelin action will help us in designing novel therapeutic agents to target malignant cells in bladder tumors. ..
  9. MOUSE MODELS OF INSULIN RESISTANCE
    Domenico Accili; Fiscal Year: 2009
    ..atypical target tissues, such as brain and pancreatic acells, is sufficient to restore metabolic control in insulin receptor (InsR)-deficient mice...
  10. Beta Cell Adaptation to Stress in Baboon Pancreas After Partial Pancreatectomy
    FRANCO BATTISTA FOLLI; Fiscal Year: 2010
    ..emphasis will be placed in amyloidogenesis, and endoplasmic reticulum (ER) stress, insulin signaling (insulin receptor substrate-2, IRS-2) and degradation (insulin degrading enzyme, IDE), and glutamate transport (GLT- 1) and ..
  11. GENE EXPRESSION IN DIABETES BY SUBTRACTIVE CLONING
    C Kahn; Fiscal Year: 2003
    ..In addition, 6 type 2 DM having low S1 and SG on fs-IVGTT will be compared with 6 offspring with high S1 and high SG, and 6 normoglycemic obese will be compared with 6 lean subjects, for differential expression in muscle and fat. ..
  12. ROLE OF INSULIN AND IGF-1 ON BROWN ADIPOCYTES
    Yu Hua Tseng; Fiscal Year: 2003
    ..the scope of experimental system to different cells lines derived from mice in which the genes for distinct insulin receptor substrate (IRS) proteins are disrupted...
  13. Proteomic charaterization of insulin signaling targets
    JONATHAN BOGAN; Fiscal Year: 2006
    ..Additionally, this work may have broader implications for insulin signaling and for protein targeting. [unreadable] [unreadable]..
  14. Diabetes Genome Anatomy Project (DGAP)
    C Kahn; Fiscal Year: 2006
    ..abstract_text> ..
  15. Role of BMPs on Brown Adipogenesis and Thermogenesis
    Yu Hua Tseng; Fiscal Year: 2006
    ..abstract_text> ..