Il6

Summary

Gene Symbol: Il6
Description: interleukin 6
Alias: Il-6, interleukin-6, B-cell hybridoma growth factor, interleukin HP-1
Species: mouse

Top Publications

  1. doi Costunolide inhibits production of tumor necrosis factor-alpha and interleukin-6 by inducing heme oxygenase-1 in RAW264.7 macrophages
    H O Pae
    Medicinal Resources Research Institute, Wonkwang University, Iksan, Chonbug, Republic of Korea
    Inflamm Res 56:520-6. 2007
  2. pmc Localized inflammation in peripheral tissue signals the CNS for sickness response in the absence of interleukin-1 and cyclooxygenase-2 in the blood and brain
    H Zhang
    Institute of Behavior Medicine, 3132 Postle Hall, 305 West 12th Avenue, Ohio State University, Columbus, OH 43210 1094, USA
    Neuroscience 157:895-907. 2008
  3. pmc Comparison of the effects of aging and IL-6 on the hepatic inflammatory response in two models of systemic injury: scald injury versus i.p. LPS administration
    Christian R Gomez
    The Burn and Shock Trauma Institute, Department of Surgery, and Immunology and Aging Program, Loyola University Medical Center, Maywood, IL 60153, USA
    Shock 31:178-84. 2009
  4. ncbi Role of interleukin-6 in bleomycin-induced lung inflammatory changes in mice
    Fumitake Saito
    Division of Pulmonary Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Am J Respir Cell Mol Biol 38:566-71. 2008
  5. ncbi Hypoxic preconditioning induces elevated expression of stanniocalcin-1 in the heart
    Johan A Westberg
    Department of Pathology, Haartman Institute, University of Helsinki, Finland
    Am J Physiol Heart Circ Physiol 293:H1766-71. 2007
  6. ncbi The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
    Ivaylo I Ivanov
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Cell 126:1121-33. 2006
  7. ncbi IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    Liang Zhou
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nat Immunol 8:967-74. 2007
  8. pmc The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells
    Oliver Dienz
    Department of Medicine Immunobiology Program, University of Vermont, Burlington, VT 05405, USA
    J Exp Med 206:69-78. 2009
  9. pmc Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells
    Helga Ellingsgaard
    Clinic for Endocrinology, Diabetes and Metabolism and Department Biomedicine, University Hospital Basel, Basel, Switzerland
    Nat Med 17:1481-9. 2011
  10. pmc Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine
    Michael H Shaw
    Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Exp Med 209:251-8. 2012

Detail Information

Publications206 found, 100 shown here

  1. doi Costunolide inhibits production of tumor necrosis factor-alpha and interleukin-6 by inducing heme oxygenase-1 in RAW264.7 macrophages
    H O Pae
    Medicinal Resources Research Institute, Wonkwang University, Iksan, Chonbug, Republic of Korea
    Inflamm Res 56:520-6. 2007
    ..7 macrophages...
  2. pmc Localized inflammation in peripheral tissue signals the CNS for sickness response in the absence of interleukin-1 and cyclooxygenase-2 in the blood and brain
    H Zhang
    Institute of Behavior Medicine, 3132 Postle Hall, 305 West 12th Avenue, Ohio State University, Columbus, OH 43210 1094, USA
    Neuroscience 157:895-907. 2008
    ..These findings suggest that local inflammation can activate the CNS via pathways distinguishable from those mediating systemic inflammation-induced CNS activation...
  3. pmc Comparison of the effects of aging and IL-6 on the hepatic inflammatory response in two models of systemic injury: scald injury versus i.p. LPS administration
    Christian R Gomez
    The Burn and Shock Trauma Institute, Department of Surgery, and Immunology and Aging Program, Loyola University Medical Center, Maywood, IL 60153, USA
    Shock 31:178-84. 2009
    ..Our results suggest that the nature of the insult will determine the degree of remote injury in aged animals. In addition, the role of IL-6 as a contributing factor of tissue injury may be insult specific...
  4. ncbi Role of interleukin-6 in bleomycin-induced lung inflammatory changes in mice
    Fumitake Saito
    Division of Pulmonary Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Am J Respir Cell Mol Biol 38:566-71. 2008
    ..These results indicate that IL-6 may play an important role in the pathogenesis of BLM-induced lung injury and subsequent fibrotic changes...
  5. ncbi Hypoxic preconditioning induces elevated expression of stanniocalcin-1 in the heart
    Johan A Westberg
    Department of Pathology, Haartman Institute, University of Helsinki, Finland
    Am J Physiol Heart Circ Physiol 293:H1766-71. 2007
    ..Our findings indicate that IL-6-induced expression of STC-1 is one molecular mechanism behind the ischemic tolerance generated by HOPC in the heart...
  6. ncbi The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
    Ivaylo I Ivanov
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Cell 126:1121-33. 2006
    ..Together, these studies suggest that RORgammat is a key regulator of immune homeostasis and highlight its potential as a therapeutic target in inflammatory diseases...
  7. ncbi IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    Liang Zhou
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nat Immunol 8:967-74. 2007
    ..IL-6 therefore orchestrates a series of 'downstream' cytokine-dependent signaling pathways that, in concert with TGF-beta, amplify RORgammat-dependent differentiation of T(H)-17 cells...
  8. pmc The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells
    Oliver Dienz
    Department of Medicine Immunobiology Program, University of Vermont, Burlington, VT 05405, USA
    J Exp Med 206:69-78. 2009
    ..Thus, IL-6 promotes antibody production by promoting the B cell helper capabilities of CD4(+) T cells through increased IL-21 production. IL-6 could therefore be a potential coadjuvant to enhance humoral immunity...
  9. pmc Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells
    Helga Ellingsgaard
    Clinic for Endocrinology, Diabetes and Metabolism and Department Biomedicine, University Hospital Basel, Basel, Switzerland
    Nat Med 17:1481-9. 2011
    ..This previously unidentified endocrine loop implicates IL-6 in the regulation of insulin secretion and suggests that drugs modulating this loop may be useful in type 2 diabetes...
  10. pmc Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine
    Michael H Shaw
    Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Exp Med 209:251-8. 2012
    ..Thus, commensal-induced IL-1β production is a critical step for sT(H)17 differentiation in the intestine, which may have therapeutic implications for T(H)17-mediated pathologies...
  11. pmc IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses
    Z Xing
    Immunology and Infection Program, Department of Pathology, McMaster University, Hamilton, Ontario, L8N 3Z5 Canada
    J Clin Invest 101:311-20. 1998
    ....
  12. ncbi Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase
    Andrew L Carey
    Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology RMIT University, Australia
    Diabetes 55:2688-97. 2006
    ..Our results demonstrate that acute IL-6 treatment enhances insulin-stimulated glucose disposal in humans in vivo, while the effects of IL-6 on glucose and fatty acid metabolism in vitro appear to be mediated by AMPK...
  13. ncbi Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects
    Victoria Rotter
    Department of Internal Medicine, Lundberg Laboratory for Diabetes Research, The Sahlgrenska Academy, Goteborg University, SE 413 45 Goteborg, Sweden
    J Biol Chem 278:45777-84. 2003
    ..We conclude that IL-6 can play an important role in insulin resistance in man and, furthermore, that it may act in concert with other cytokines that also are up-regulated in adipose cells in insulin resistance...
  14. ncbi Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice
    D E Cressman
    Department of Genetics and Medicine, University of Pennsylvania School of Medicine, 705a Stellar Chance, 422 Curie Boulevard, Philadelphia, PA 19104 6145, USA
    Science 274:1379-83. 1996
    ....
  15. pmc Interleukin 6 is required for the development of collagen-induced arthritis
    T Alonzi
    Istituto Ricerche di Biologia Molecolare P Angeletti, 00040 Pomezia, Rome, Italy
    J Exp Med 187:461-8. 1998
    ..These results are discussed in the light of the present knowledge of cytokine networks in chronic inflammatory disorders and suggest that IL-6 receptor antagonists might be beneficial for the treatment of RA...
  16. ncbi TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology
    Mandy J McGeachy
    Schering Plough Biopharma, Palo Alto, California 94304, USA
    Nat Immunol 8:1390-7. 2007
    Studies have shown that transforming growth factor-beta (TGF-beta) and interleukin 6 (IL-6) are required for the lineage commitment of pathogenic IL-17-producing T helper cells (T(H)-17 cells)...
  17. ncbi Impaired immune and acute-phase responses in interleukin-6-deficient mice
    M Kopf
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Nature 368:339-42. 1994
    ..We conclude that IL-6 production induced by injury or infection is an important in vivo SOS signal which coordinates activities of liver cells, macrophages and lymphocytes...
  18. pmc Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion
    V Poli
    Istituto di Ricerche di Biologia Molecolare P Angeletti, Rome, Italy
    EMBO J 13:1189-96. 1994
    ..These findings indicate that IL-6 plays an important role in the local regulation of bone turnover and, at least in mice, appears to be essential for the bone loss caused by estrogen deficiency...
  19. pmc IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells
    Liying Guo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:13463-8. 2009
    ....
  20. pmc Tolerogenic function of Blimp-1 in dendritic cells
    Sun Jung Kim
    Center for Autoimmune and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    J Exp Med 208:2193-9. 2011
    ..This study is of particular interest because a polymorphism of Blimp-1 associates with SLE...
  21. pmc Vascular endothelial growth factor is a key mediator in the development of T cell priming and its polarization to type 1 and type 17 T helper cells in the airways
    You Sun Kim
    Department of Life Science, Postech Biotech Center, Pohang University of Science and Technology, Pohang, Republic of Korea
    J Immunol 183:5113-20. 2009
    ..These findings indicate that VEGF produced by LPS plays a key role in activation of naive T cells and subsequent polarization to Th1 and Th17 cells...
  22. ncbi The inflammatory response in interleukin-1 beta-deficient mice: comparison with other cytokine-related knock-out mice
    G Fantuzzi
    Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA
    J Leukoc Biol 59:489-93. 1996
    ....
  23. ncbi Interleukin 6 is important for survival after partial hepatectomy in mice
    Alex Blindenbacher
    Department of Research, University Hospital Basel, Basel, Switzerland
    Hepatology 38:674-82. 2003
    The response to partial hepatectomy (PH) is impaired in interleukin 6 (IL-6)-deficient mice...
  24. doi Heat shock transcription factor 1 inhibits expression of IL-6 through activating transcription factor 3
    Ryosuke Takii
    Department of Biochemistry and Molecular Biology, Yamaguchi University School of Medicine, Ube, Japan
    J Immunol 184:1041-8. 2010
    ..These results demonstrate a novel inhibitory pathway for inflammatory cytokines...
  25. pmc Exacerbation of CNS inflammation and neurodegeneration by systemic LPS treatment is independent of circulating IL-1β and IL-6
    Carol L Murray
    School of Biochemistry and Immunology, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    J Neuroinflammation 8:50. 2011
    ..Here we investigated whether inhibition of systemic cytokine synthesis using the anti-inflammatory steroid dexamethasone-21-phosphate was sufficient to block any or all of these responses...
  26. pmc Defective inflammatory response in interleukin 6-deficient mice
    E Fattori
    Istituto di Ricerche di Biologia Molecolare IRBM P Angeletti, Pomezia, Roma
    J Exp Med 180:1243-50. 1994
    ..b>Interleukin 6 (IL-6) is considered an important mediator of the inflammatory response, together with IL-1 and tumor necrosis ..
  27. ncbi The importance of IL-1 beta and TNF-alpha, and the noninvolvement of IL-6, in the development of monoclonal antibody-induced arthritis
    Takashi Kagari
    Biological Research Laboratories, Sankyo Co, Ltd, Tokyo, Japan
    J Immunol 169:1459-66. 2002
    ..Because arthritis was also developed in SCID mice, the development of arthritis in the Ab-induced mice model is due to a mechanism that does not involve T or B cells...
  28. ncbi IL-6 regulates neutrophil trafficking during acute inflammation via STAT3
    Ceri A Fielding
    Department of Nephrology, School of Medicine, Cardiff University, Cardiff, United Kingdom
    J Immunol 181:2189-95. 2008
    ....
  29. pmc Interleukin-6 regulates pancreatic alpha-cell mass expansion
    Helga Ellingsgaard
    Division of Endocrinology and Diabetes and Center for Integrated Human Physiology, University Hospital of Zurich, 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 105:13163-8. 2008
    ....
  30. pmc Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities
    Fouad Eddahri
    Laboratoire de Physiologie Animale, Universite Libre de Bruxelles, Brussels, Belgium
    Blood 113:2426-33. 2009
    ..Collectively, these data indicate that the ability to provide B-cell help is regulated by IL-6/IL-21 through STAT3 activation, independently of Th1, Th2, Th17, or follicular helper T cell (T(FH)) differentiation...
  31. doi Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model
    Satoshi Matsumoto
    Yakult Central Institute for Microbiological Research, Tokyo, Japan
    J Immunol 184:1543-51. 2010
    ..Treatment with soluble gp130Fc significantly reduced the CApC. IL-6 trans-signaling in epithelial cells induced by macrophage-derived IL-6/sIL-6R alpha plays a crucial role in the development of CAC...
  32. doi Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance
    V B Matthews
    Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, 3008, Vic, Australia
    Diabetologia 53:2431-41. 2010
    ..We aimed to determine whether global deletion of Il6 in mice (Il6 (-/-)) results in standard chow-induced and high-fat diet (HFD)-induced obesity, hepatosteatosis, ..
  33. ncbi Interleukin-6-deficient mice develop mature-onset obesity
    Ville Wallenius
    Research Center for Endocrinology and Metabolism, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden
    Nat Med 8:75-9. 2002
    ..We investigated the impact of loss of IL-6 on body composition in mice lacking the gene encoding IL-6 (Il6-/- mice) and found that they developed mature-onset obesity that was partly reversed by IL-6 replacement...
  34. ncbi Role of IL-6 and TNF in thermoregulation and survival during sepsis in mice
    L R Leon
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87185, USA
    Am J Physiol 275:R269-77. 1998
    ..The enhanced lethality of CLP-treated female mice supports a role for sex steroids during sepsis...
  35. ncbi Role of interleukin-6 for LV remodeling and survival after experimental myocardial infarction
    Martin Fuchs
    Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Germany
    FASEB J 17:2118-20. 2003
    ....
  36. ncbi Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-beta
    Lili Xu
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 178:6725-9. 2007
    ..They thus have important implications to our understanding of regulatory T cell function and their possible therapeutic use...
  37. ncbi Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
    Willscott E Naugler
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Cancer Center, University of California, San Diego, CA 93093, USA
    Science 317:121-4. 2007
    ..We propose that estrogen-mediated inhibition of IL-6 production by KCs reduces liver cancer risk in females, and these findings may be used to prevent HCC in males...
  38. doi IL-6 deficiency in mice neither impairs induction of metabolic genes in the liver nor affects blood glucose levels during fasting and moderately intense exercise
    L Fritsche
    Department of Internal Medicine, Division of Pathobiochemistry and Clinical Chemistry, University of Tuebingen, Otfried Mueller Strasse 10, 72076 Tuebingen, Germany
    Diabetologia 53:1732-42. 2010
    ..IL-6 has been implicated in the regulation of gluconeogenic genes, but the results are contradictory and the relevance of IL-6 for fasting- and exercise-induced hepatic glucose production is not clear...
  39. doi Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptor
    Molly M McFarland-Mancini
    Department of Cancer and Cell Biology, Vontz Center for Molecular Studies, University of Cincinnati, Cincinnati, OH 45267, USA
    J Immunol 184:7219-28. 2010
    ..These findings underscore a deeper complexity for IL-6Ralpha function in inflammation than has been recognized previously...
  40. doi Interleukin-6 promotes pulmonary emphysema associated with apoptosis in mice
    Saleela M Ruwanpura
    Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, 27 31 Wright Street, Clayton 3168, Victoria, Australia
    Am J Respir Cell Mol Biol 45:720-30. 2011
    ..We propose that the discrete targeting of IL-6 signaling may provide an effective therapeutic strategy against human lung disease...
  41. pmc Particulate matter-induced lung inflammation increases systemic levels of PAI-1 and activates coagulation through distinct mechanisms
    G R Scott Budinger
    Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
    PLoS ONE 6:e18525. 2011
    ..We sought to determine whether exposure of mice to PM increases the levels of PAI-1, a major regulator of thrombolysis, via a similar or distinct mechanism...
  42. ncbi Interleukin-6/glycoprotein 130-dependent pathways are protective during liver regeneration
    Torsten Wuestefeld
    Department of Gastroenterology, Hepatology, and Endocrinology, Medizinische Hochschule Hannover, 30625 Hannover, Germany
    J Biol Chem 278:11281-8. 2003
    After tissue loss the liver has the unique capacity to restore its mass by hepatocyte proliferation. Interleukin-6 (IL6)-deficient mice show a lack in DNA synthesis after partial hepatectomy (PH)...
  43. pmc Feeding, exploratory, anxiety- and depression-related behaviors are not altered in interleukin-6-deficient male mice
    Artur H Swiergiel
    Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, 71130 3932, USA
    Behav Brain Res 171:94-108. 2006
    ..It is concluded that the lack of IL-6 is not associated with substantial alterations in several different mouse behaviors, and in the responses to restraint, IL-1beta, IL-6 and LPS...
  44. doi Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction
    Hideki Ogura
    Laboratory of Developmental Immunology, Graduate School of Frontier Biosciences, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    Immunity 29:628-36. 2008
    ..Because this mechanism also enhanced experimental autoimmune encephalomyelitis (EAE) in wild-type mice, it may be a general etiologic process underlying other Th17 cell-mediated autoimmune diseases...
  45. pmc Flk-1+ mesenchymal stem cells aggravate collagen-induced arthritis by up-regulating interleukin-6
    B Chen
    Institute of Basic Medical Sciences and School of Basic Medicine, Center of Excellence in Tissue Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Clin Exp Immunol 159:292-302. 2010
    ..When Flk-1(+) MSCs are used for patients, we should be cautious about subjects with rheumatoid arthritis...
  46. pmc Interleukin (IL)-6 gene expression in the central nervous system is necessary for fever response to lipopolysaccharide or IL-1 beta: a study on IL-6-deficient mice
    Z Chai
    Department of Neurochemistry and Neurotoxicology, Arrhenius Laboratories for Natural Sciences, Stockholm University, Sweden
    J Exp Med 183:311-6. 1996
    ..These results suggest that central IL-6 is a necessary component of the fever response to both endogenous (IL-1 beta) and exogenous (LPS) pyrogens in mice and that IL-6 acts downstream from both peripheral and central IL-1 beta...
  47. ncbi Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice
    Peter J Klover
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Diabetes 52:2784-9. 2003
    ..These data suggest that chronic IL-6 treatment selectively impairs hepatic insulin signaling in vivo, further supporting a role for IL-6 in hepatic insulin resistance of obesity...
  48. ncbi Interleukin-6 facilitates lipopolysaccharide-induced disruption in working memory and expression of other proinflammatory cytokines in hippocampal neuronal cell layers
    Nathan L Sparkman
    Laboratory of Integrative Immunology and Behavior, Department of Animal Sciences, University of Illinois, Urbana, Illinois 61801, USA
    J Neurosci 26:10709-16. 2006
    ..Collectively, these data suggest that humoral and neural immune-to-brain communication pathways are intact in IL-6-deficient mice but that, in the absence of IL-6, the central cytokine compartment is hyporesponsive...
  49. pmc Phospholipase Cgamma2 is critical for Dectin-1-mediated Ca2+ flux and cytokine production in dendritic cells
    Shengli Xu
    Laboratory of Immunology, Bioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore 138668
    J Biol Chem 284:7038-46. 2009
    ..Thus, our data indicate that pattern recognition receptors such as Dectin-1 could elicit Ca2+ signaling and that PLCgamma2 is a critical player in the Dectin-1 signal transduction pathway...
  50. pmc In vivo regulation of Bcl6 and T follicular helper cell development
    Amanda C Poholek
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 185:313-26. 2010
    ..These data increase our understanding of Bcl6 regulation in T(FH) cells and their differentiation in vivo and identifies a new surface marker that may be functionally relevant in this subset...
  51. pmc Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis
    Hong Ji
    Section on Immunology and Immunogenetics, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 196:77-85. 2002
    ..The variability in the requirement for TNF-alpha, reminiscent of that observed in treated rheumatoid arthritis patients, did not appear genetically programmed but related instead to subtle environmental changes...
  52. pmc Role of interleukin-6 in mortality from and physiologic response to sepsis
    Daniel G Remick
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0602, USA
    Infect Immun 73:2751-7. 2005
    ..We tested whether interleukin 6 knockout (IL-6KO) mice were more susceptible to sepsis mortality induced by cecal ligation and puncture...
  53. pmc IL-6 is required for airway mucus production induced by inhaled fungal allergens
    Wendy A Neveu
    Department of Medicine, Division of Immunobiology, University of Vermont, Burlington, VT 05405, USA
    J Immunol 183:1732-8. 2009
    ..Thus, IL-6 is a key regulator of specific hallmark features of allergic airway inflammation and it could be a potential target for pulmonary diseases that are associated with goblet cell metaplasia and mucus hypersecretion...
  54. pmc Role of host cytokine responses in the pathogenesis of avian H5N1 influenza viruses in mice
    Kristy J Szretter
    Influenza Branch MS G 16, Division of Viral and Ricksettial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    J Virol 81:2736-44. 2007
    ..These results suggest that TNF-alpha may contribute to morbidity during H5N1 influenza virus infection, while IL-1 may be important for effective virus clearance in nonlethal H5N1 disease...
  55. pmc Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice
    Jiusong Sun
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 117:3359-68. 2007
    ....
  56. pmc In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells
    Matthias Lochner
    Laboratory of Lymphoid Tissue Development, Centre National de la Recherche Scientifique URA1961, Institut Pasteur, Paris 75724, France
    J Exp Med 205:1381-93. 2008
    ....
  57. ncbi Reciprocal regulation of IL-6 and IL-10 balance by HGF via recruitment of heme oxygenase-1 in macrophages for attenuation of liver injury in a mouse model of endotoxemia
    Miyuki Kamimoto
    Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, Suita, Osaka, 565 0871, Japan
    Int J Mol Med 24:161-70. 2009
    ..Based on the current data, we conclude that up-regulation of HO-1 plays an important role in HGF-mediated hepatoprotection during endotoxemia, by favoring production of IL-10 over IL-6...
  58. ncbi Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment
    M Romano
    Istituto Ricerche Farmacologiche Mario Negri, Milan, Italy
    Immunity 6:315-25. 1997
    ..Hence, in vivo and in vitro evidence supports the concept that the IL-6 system plays an unexpected positive role in local inflammatory reactions by amplifying leukocyte recruitment...
  59. pmc Hepatocellular hyperplasia, plasmacytoma formation, and extramedullary hematopoiesis in interleukin (IL)-6/soluble IL-6 receptor double-transgenic mice
    P Schirmacher
    Institute of Pathology, University of Mainz, Germany
    Am J Pathol 153:639-48. 1998
    ..Interestingly, the complex of IL-6 and the soluble interleukin 6 receptor (sIL-6R) activates target cells that do not express the membrane-bound IL-6R and therefore cannot ..
  60. ncbi IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
    Hideo Yasukawa
    Institute of Molecular Medicine and Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0641, USA
    Nat Immunol 4:551-6. 2003
    ..SOCS3 specifically prevents activation of STAT3 by IL-6 but not IL-10. Taken together, these data indicate that SOCS3 selectively blocks signaling by IL-6, thereby preventing its ability to inhibit LPS signaling...
  61. ncbi Interleukin-1 and its biologically related cytokines
    C A Dinarello
    Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02111
    Adv Immunol 44:153-205. 1989
  62. pmc Cardiotrophin-1 defends the liver against ischemia-reperfusion injury and mediates the protective effect of ischemic preconditioning
    María Iñiguez
    Division of Hepatology and Gene Therapy, Center for Applied Medical Research CIMA, Clinica Universitaria and Medical School, University of Navarra, Pamplona 31008, Spain
    J Exp Med 203:2809-15. 2006
    ..In conclusion, CT-1 is an essential endogenous defense of the liver against I/R and is a key mediator of the protective effect induced by IP...
  63. ncbi Opposing roles of gp130-mediated STAT-3 and ERK-1/ 2 signaling in liver progenitor cell migration and proliferation
    George C T Yeoh
    UWA Centre for Medical Research, The Western Australian Institute for Medical Research, Perth, Australia
    Hepatology 45:486-94. 2007
    ..For the first time, we have dissected the gp130-mediated signaling pathways, which influence liver progenitor oval cell proliferation...
  64. ncbi Hypoxic preconditioning induces neuroprotective stanniocalcin-1 in brain via IL-6 signaling
    Johan A Westberg
    Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland
    Stroke 38:1025-30. 2007
    ..We originally reported expression of mammalian STC-1 in brain neurons and showed that STC-1 guards neurons against hypercalcemic and hypoxic damage...
  65. doi STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria
    Lobelia Samavati
    Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Mol Immunol 46:1867-77. 2009
    ..This inhibition did not affect caspase-1 activation. These results highlight the complex role of STAT3 in cytokine production and the key role of STAT3 tyrosine phosphorylation in IL-1beta and IL-6 production in response to inflammation...
  66. ncbi Regulation of tissue inhibitor of metalloproteinase-1 in fibroblasts and acute phase proteins in hepatocytes in vitro by mouse oncostatin M, cardiotrophin-1, and IL-6
    C D Richards
    Department of Pathology, McMaster University, Hamilton, Ontario, Canada
    J Immunol 159:2431-7. 1997
    ..These results also suggest that mOSM is an important cytokine in inflammation, through modulation of fibroblast function as well as hepatocyte responses...
  67. ncbi Production of IL-1 receptor antagonist by hepatocytes is regulated as an acute-phase protein in vivo
    C Gabay
    Division of Rheumatology, University Hospital of Geneva, Geneva, Switzerland
    Eur J Immunol 31:490-9. 2001
    ..In contrast, local production of IL-1Ra is independent of IL-6. Taken together, these results indicate that IL-1Ra is produced by the liver as an acute-phase protein in vivo...
  68. pmc IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
    Sergei Grivennikov
    Laboratory of Gene Regulation and Signal Transduction, UCSD School of Medicine, University of California San Diego, La Jolla, CA 92093 0723, USA
    Cancer Cell 15:103-13. 2009
    ..Proinflammatory cytokines have been suggested to regulate preneoplastic growth during CAC tumorigenesis. Interleukin 6 (IL-6) is a multifunctional NF-kappaB-regulated cytokine that acts on epithelial and immune cells...
  69. pmc Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation
    Vanesa Esteban
    Cellular Biology in Renal Diseases Laboratory, Fundacion Jimenez Diaz, Universidad Autonoma Madrid, Madrid, Spain
    PLoS ONE 4:e5406. 2009
    ..Therefore, the blockade of the NF-kappaB-activating properties of the receptor Mas could be a new strategy in the therapy of failing kidney...
  70. doi Annexin-1 regulates macrophage IL-6 and TNF via glucocorticoid-induced leucine zipper
    Yuan H Yang
    Centre for Inflammatory Diseases, Department of Medicine, Monash University, Clayton, Victoria, Australia
    J Immunol 183:1435-45. 2009
    ..These data confirm ANXA1 as a key inhibitor of macrophage cytokine expression and identify GILZ as a previously unrecognized mechanism of the anti-inflammatory effects of ANXA1...
  71. doi Interleukin-6 enhances matrix metalloproteinase-14 expression via the RAF-mitogen-activated protein kinase kinase-extracellular signal-regulated kinase 1/2-activator protein-1 pathway
    Min Feng
    Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Shandong University Qilu Hospital, Jinan, Shandong, China
    Clin Exp Pharmacol Physiol 37:162-6. 2010
    ..4. These findings suggest a novel molecular pathway for inflammation-associated ECM dysregulation, which may account for atherosclerotic plaque rupture...
  72. doi IL-6 production is positively regulated by two distinct Src homology domain 2-containing tyrosine phosphatase-1 (SHP-1)-dependent CCAAT/enhancer-binding protein β and NF-κB pathways and an SHP-1-independent NF-κB pathway in lipopolysaccharide-stimulated b
    Dorothy Rego
    Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario KIH 8M5, Canada
    J Immunol 186:5443-56. 2011
    ....
  73. ncbi Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6
    Luc Vallières
    Laboratories of Neuronal Structure and Function, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 22:486-92. 2002
    ..These findings suggest that long-term exposure of the brain to proinflammatory mediators such as IL-6, as is seen in certain degenerative disorders and infections, can interfere with adult neurogenesis...
  74. ncbi IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state
    Mika Nishihara
    Laboratory of Developmental Immunology, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Osaka, Japan
    Int Immunol 19:695-702. 2007
    ..Therefore, blockade of IL-6-gp130-STAT3 pathway in CD4+ T cells could be a good target for controlling unwanted Th17-mediated immune responses including autoimmune diseases...
  75. doi gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis
    Julia Bollrath
    2nd Department of Medicine, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
    Cancer Cell 15:91-102. 2009
    ....
  76. ncbi Establishment of the role of IL-6 and TNF receptor 1 using gene knockout mice
    H Bluethmann
    Department of Biology, F Hoffmann La Roche Ltd, Basel, Switzerland
    J Leukoc Biol 56:565-70. 1994
    ..Results for interferon-- and interferon-gamma receptor-deficient mice are included for comparison...
  77. ncbi Interleukin-6 overexpression cannot generate serious disorders in severe combined immunodeficiency mice
    A Katsume
    Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co Ltd, Komakado 1 135, Gotemba shi, Shizuoka, 412, Japan
    Clin Immunol Immunopathol 82:117-24. 1997
    ....
  78. ncbi Caspase-1 regulates the inflammatory process leading to autoimmune demyelination
    R Furlan
    Experimental Neuroimmunotherapy Unit, Department of Biotechnology, San Raffaele Scientific Institute, Milan, Italy
    J Immunol 163:2403-9. 1999
    ..These results indicate that caspase-1 plays an important role in the early stage of the immune-mediated inflammatory process leading to EAE, thus representing a possible therapeutic target in the acute phase of relapsing remitting MS...
  79. ncbi HMGB-1, a DNA-binding protein with cytokine activity, induces brain TNF and IL-6 production, and mediates anorexia and taste aversion
    Davide Agnello
    Laboratory of Neuroimmunology, Mario Negri Institute for Pharmacological Research, 20157 Milano, Italy
    Cytokine 18:231-6. 2002
    ..In a model of endotoxemia, passive immunization with anti-HMG-1 antibodies attenuated the development of hypophagia, indicating that HMG-1 is a mediator of sickness behaviour associated with endotoxemia...
  80. ncbi Expression of the hematopoietic stem cell antigen Sca-1 (LY-6A/E) in liver sinusoidal endothelial cells: possible function of Sca-1 in endothelial cells
    Gonzalo Luna
    Laboratorio de Patología Celular y Molecular, Centro de Medicina Experimental, Instituto Venezolano de Investigaciones Cientificas IVIC, Caracas 1020 A, Venezuela
    Stem Cells Dev 13:528-35. 2004
    ..These results suggest that Sca-1 may participate in several clinical conditions such as angiogenesis and inflammation...
  81. ncbi IL-6 is not required for parathyroid hormone stimulation of RANKL expression, osteoclast formation, and bone loss in mice
    CHARLES A O'BRIEN
    Division of Endocrinology and Metabolism, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Am J Physiol Endocrinol Metab 289:E784-93. 2005
    ..These results demonstrate that IL-6 is not required for the osteoclast formation and bone loss that accompanies continuous elevation of PTH...
  82. pmc IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
    Elizabeta Nemeth
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles UCLA, Los Angeles, California, USA
    J Clin Invest 113:1271-6. 2004
    ....
  83. pmc Ambient particulate matter accelerates coagulation via an IL-6-dependent pathway
    Gokhan M Mutlu
    Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    J Clin Invest 117:2952-61. 2007
    ..These results provide a potential mechanism linking ambient particulate matter exposure and thrombotic events...
  84. ncbi Long-term consequences of interleukin-6 overexpression in transgenic mice
    C Woodroofe
    European Molecular Biology Laboratory, Heidelberg, Germany
    DNA Cell Biol 11:587-92. 1992
    ..These results indicate that the side effects of long-term treatment with IL-6 are relatively moderate, and that IL-6 might be used to mediate the expression of heterologous genes in the context of functional studies...
  85. pmc IgG1 plasmacytosis in interleukin 6 transgenic mice
    S Suematsu
    Division of Immunology, Osaka University, Japan
    Proc Natl Acad Sci U S A 86:7547-51. 1989
    b>Interleukin 6 (IL-6) has been suggested to be involved in the pathogenesis of polyclonal and monoclonal plasma cell abnormalities...
  86. pmc Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas
    J Van Snick
    Proc Natl Acad Sci U S A 83:9679-83. 1986
    ....
  87. ncbi Development of progressive kidney damage and myeloma kidney in interleukin-6 transgenic mice
    E Fattori
    Department of Genetics of IRBM P Angeletti, Pomezia, Roma, Italy
    Blood 83:2570-9. 1994
    ..The pathogenetic role of IL-6 overproduction and of the resulting serum protein overload in the kidney damage is discussed...
  88. pmc Accelerated Nerve Regeneration in Mice by upregulated expression of interleukin (IL) 6 and IL-6 receptor after trauma
    H Hirota
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    J Exp Med 183:2627-34. 1996
    In this study we aimed to examine a role for interleukin 6 (IL-6) and its receptor (IL-6R) in peripheral nerve regeneration in vivo...
  89. pmc Defective development of pristane-oil-induced plasmacytomas in interleukin-6-deficient BALB/c mice
    G Lattanzio
    Dipartimento di Patologia Umana e Medicina Sociale, Universita di Chieti, Italy
    Am J Pathol 151:689-96. 1997
    ....
  90. pmc Interleukin 6 plays a key role in the development of antigen-induced arthritis
    S Ohshima
    Department of Medicine III, Osaka University Medical School, Suita City, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 95:8222-6. 1998
    ..Taken together, these results indicate that IL-6 may play a key role in the development of AIA at the inductive as well as the effector phase, and the blockade of IL-6 is possibly beneficial in the treatment of rheumatoid arthritis...
  91. pmc Interleukin 6 dependence of anti-DNA antibody production: evidence for two pathways of autoantibody formation in pristane-induced lupus
    H B Richards
    Department of Medicine, Thurston Arthritis Research Center, University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill 27599 7280, USA
    J Exp Med 188:985-90. 1998
    ..This may reflect the differential IL-6 dependence of the two responses...
  92. pmc Interleukin 6 influences germinal center development and antibody production via a contribution of C3 complement component
    M Kopf
    Basel Institute for Immunology, CH 4005 Basel, Switzerland
    J Exp Med 188:1895-906. 1998
    ..These findings reveal that the germinal center produces and uses molecules of the innate immune system, evolutionarily pirating them in order to optimally generate high affinity antibody responses...
  93. ncbi IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells
    E B Samoilova
    Institute for Human Gene Therapy and Department of Molecular and Cellular Engineering, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Immunol 161:6480-6. 1998
    ..These results strongly suggest that IL-6 plays a crucial role in the activation and differentiation of autoreactive T cells in vivo and that blocking IL-6 function can be an effective means to prevent EAE...
  94. ncbi Strongly compromised inflammatory response to brain injury in interleukin-6-deficient mice
    M Penkowa
    Institute of Medical Anatomy, Section C, The Panum Institute, University of Copenhagen, Denmark
    Glia 25:343-57. 1999
    ..Furthermore, our results suggest IL-6 is important for neuroprotection and the induction of GM-CSF and MT expression. The opposing effect of IL-6 on MT-I+II and MT-III levels in the damaged brain suggests MT isoform-specific functions...
  95. ncbi Interleukin-6 is a needed proinflammatory cytokine in the prolonged neural activity and transcriptional activation of corticotropin-releasing factor during endotoxemia
    L Vallières
    Department of Anatomy and Physiology, Laval University, Sainte Foy, Quebec, Canada
    Endocrinology 140:3890-903. 1999
    ....
  96. ncbi Expression and self-regulatory function of cardiac interleukin-6 during endotoxemia
    H Saito
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Am J Physiol Heart Circ Physiol 279:H2241-8. 2000
    ..Thus cardiac IL-6, expressed mainly by nonmyocardial cells via IL-1beta action during endotoxemia, is likely to suppress expression of proinflammatory mediators and to regulate itself via a negative feedback mechanism...
  97. pmc IL-6 transgenic mouse model for extraosseous plasmacytoma
    Alexander L Kovalchuk
    Laboratory of Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:1509-14. 2002
    ..These findings provide a unique model of extramedullary PCT for studies on pathogenesis and treatment and suggest a previously unappreciated role for IL-6 in the genesis of germinal center-derived lymphomas...
  98. ncbi Resistance to experimental autoimmune myasthenia gravis in IL-6-deficient mice is associated with reduced germinal center formation and C3 production
    Caishu Deng
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 1070, USA
    J Immunol 169:1077-83. 2002
    ..The data provide the first direct genetic evidence for a key role of IL-6 in the autoimmune response to AChR and in EAMG pathogenesis...
  99. ncbi Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice
    Niall C Tebbutt
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Nat Med 8:1089-97. 2002
    ..We propose a model whereby mucosal wound healing depends solely on activation of STAT1/3, whereas gastric hyperplasia ensues when the coordinated activation of the STAT1/3 and SHP2-Ras-ERK pathways is disrupted...
  100. ncbi Interleukin-6-deficient mice resist development of autoimmune myocarditis associated with impaired upregulation of complement C3
    Urs Eriksson
    Department of Internal Medicine, Medical ICU, University Hospital, Basel, Switzerland
    Circulation 107:320-5. 2003
    ..Interleukin (IL)-6 regulates various aspects of the immune response. In the context of heart diseases, it has been recognized as a prognostic factor for dilated cardiomyopathy, which often results from myocarditis...
  101. ncbi Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes
    Joseph J Senn
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    J Biol Chem 278:13740-6. 2003
    ..These data suggest that induction of SOCS-3 in liver may be an important mechanism of IL-6-mediated insulin resistance...

Research Grants35

  1. Host Immunoregulation of Response to Antileishmanial Chemotherapy
    Henry Murray; Fiscal Year: 2007
    ..abstract_text> ..
  2. Role of p38 MAPK in IL-4-induced IL-6 expression in vascular endothelium
    Yongwoo Lee; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  3. NEURONAL ACTIONS OF HOST FACTORS IN NEUROAIDS
    DONNA GRUOL; Fiscal Year: 2005
    ..The overall design will address effects of both acute and chronic chemokine exposure on neuronal cell function and will include examination of two distinct classes of neurons, excitatory glutamatergic and inhibitory GABAergic neurons. ..
  4. Immune Pathways as Prerequisites for Adjuvants' Efficacy
    George Hui; Fiscal Year: 2004
    ....
  5. IN VIVO REGULATION OF IL6 AND IL6R GENE EXPRESSION
    CHARLES O BRIEN; Fiscal Year: 2002
    ..Finally, cis-acting regulatory elements in the IL-6 promoter that are the targets for estrogen and PTH actions in vivo will be identified. ..
  6. HSP25 and HSP20 Regulation in Skeletal Muscle Adapt
    KIMBERLY HUEY; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  7. Pattern Recognition Molecule Mindin As Adjuvant
    You Wen He; Fiscal Year: 2007
    ..Third, Mindin fused DNA plasmids will be examined for their efficacy in protecting influenza virus infection. [unreadable] [unreadable]..
  8. IL-6 Regulation of Hippocampal Synaptic Function
    Donna L Gruol; Fiscal Year: 2010
    ..The proposed studies focus on this issue as it relates to CNS disorders. ..
  9. HTLV deregulation of NF-kappaB2 p100 processing in tumor
    Gutian Xiao; Fiscal Year: 2010
    ..The completion of the proposed studies may lead to new therapeutic strategies for p100 processing-associated human diseases. ..
  10. Prevent HIV protease inhibitor-induced atherosclerosis by Berberine
    HUIPING ROSE ZHOU; Fiscal Year: 2010
    ..Completion of these specific aims will help identify and establish new therapeutic strategies for HIV infection. ..
  11. CXC CHEMOKINES AND LIVER REGENERATION
    Lisa Colletti; Fiscal Year: 2009
    ..To investigate this hypothesis, we will examine specific MIP-2-related mechanisms of hepatocyte proliferation and apoptosis following 70% hepatectomy, as well as IP-10's modulating effects in this system. ..
  12. p38 MAP kinase in early thymocyte development
    Mercedes Rincon; Fiscal Year: 2008
    ..abstract_text> ..
  13. Matrix Metalloproteinases, Exercise, and Muscle Damage
    David Allen; Fiscal Year: 2008
    ..Finally, subjects will be genotyped for known functional MMP promoter polymorphisms, which will be correlated with MMP levels and muscle damage and soreness following eccentric exercise. ..
  14. Investigation of hepcidin in mammalian iron homeostasis
    Cindy Roy; Fiscal Year: 2008
    ..Future work will focus on investigating the role of the hepcidin receptor and its homologs in iron metabolism and the anemia of chronic disease ..
  15. Role of Matrix Metalloproteinase-2 in Liver Fibrosis
    Meena Bansal; Fiscal Year: 2007
    ..Findings from these investigations may lead to novel approaches to the treatment of chronic fibrosing liver disease. [unreadable] [unreadable]..
  16. Gender differences in liver IL-6R expression
    RANDLE GALLUCCI; Fiscal Year: 2007
    ..By exposing ethanol- consuming rats to IL-6R agonists, it should be possible to correlate damage with receptor activation. [unreadable] [unreadable] [unreadable]..
  17. Il-6 type cytokine protection from hyperoxic lung injury
    Aaron Waxman; Fiscal Year: 2007
    ..abstract_text> ..
  18. Extracellular Matrix Protein in Innate Immunity
    You Wen He; Fiscal Year: 2007
    ..Results from this proposal will provide novel insights on the mechanisms of the innate immune response and may have implication for clinical treatment of septic shock and other microbe caused diseases. [unreadable] [unreadable]..
  19. ORPHAN NUCLEAR RORgammat IN THYMOCYTE DIFFERENTIATION
    You Wen He; Fiscal Year: 2006
    ..In addition, results from this application will also provide insights for the role of ROR-gamma-t in tumorigenesis. ..
  20. CYTOKINE/CHEMOKINE ACTIONS ON DEVELOPING CNS NEURONS
    DONNA GRUOL; Fiscal Year: 2002
    ....
  21. ROLE OF PKD IN LEUKOCYTE ACTIVATION BY CPG DNA
    Ae Kyung Yi; Fiscal Year: 2002
    ..This proposed study would enhance our understanding of how CpG motifs in bacterial DNA break immune tolerance and contribute to chrome inflammatory autoimmune diseases such as arthritis. ..
  22. HOST IMMUNOREGULATION OF ANTILEISHMANIAL CHEMOTHERAPY
    Henry Murray; Fiscal Year: 2005
    ..And Aim 3: Characterize immunostimulation in AmB's efficacy, and in recrudescent infection following AmB therapy, pinpoint the likely cytokine-driven T cell mechanism which prevents post-treatment relapse. ..
  23. Lung epithelium-derived IL-6 in CD4+ T cell immune resp*
    Mercedes Rincon; Fiscal Year: 2004
    ..abstract_text> ..
  24. Role of arginine deficiency in pathogenesis of lupus
    Minoru Satoh; Fiscal Year: 2004
    ..abstract_text> ..
  25. Role of Galectin-4 in Colitis
    Atsushi Mizoguchi; Fiscal Year: 2008
    ..These studies will not only enhance understanding of the pathogenic mechanisms of IBD but also provide important information to develop new therapeutic approaches for human IBD. ..
  26. UCP5-- Balancing Metabolism and Oxidation in Aging Brain
    LAURA DUGAN; Fiscal Year: 2004
    ....
  27. Identification of an IL-6 induced keratinocyte motogen
    RANDLE GALLUCCI; Fiscal Year: 2008
    ..The results of these experiments will hopefully lead to the eventual development of a useful treatment for chronic wounds. ..
  28. Cell-targeting peptide nucleic acids for hormone-refractory prostate cancer
    Beverly Barton; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  29. SCF in liver repair after hepatectomy or toxic injury
    Lisa Colletti; Fiscal Year: 2006
    ..These studies will help to elucidate novel mechanisms in SCF-mediated hepatocyte protection and regeneration in a clinically relevant liver resection and toxicity model. ..
  30. HIV Protease Inhibitors, the Unfolded Protein Response and Atherosclerosis
    Huiping Zhou; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  31. IL-6 regulation of matrix degradation in liver fibrosis
    Meena Bansal; Fiscal Year: 2006
    ..MMP-2 in vivo; (4) To test the importance of MMP-2 in liver injury in vivo by administering MMP-2 inhibitors to IL6 +/+ and-/-mice with acute and chronic liver injury...
  32. MECHANISMS OF NEUROPROTECTION BY C60 DERIVATIVES
    LAURA DUGAN; Fiscal Year: 2001
    ....
  33. Monocyte Biology and Biodefense
    DOUGLAS DREVETS; Fiscal Year: 2005
    ..These data will then catalyze development of rational therapies to improve host defenses against severe and overwhelming infection by category A and B intracellular bacterial pathogens. ..
  34. Somatic Ca2+ Signaling in CNS Neurons
    DONNA GRUOL; Fiscal Year: 2007
    ..However, the general principles identified by the studies will also contribute significantly to our understanding of the role of activity-dependent gene expression during development in other CNS neuronal types. [unreadable] [unreadable]..
  35. Induction of immunological paralysis by CpG DNA
    Ae Kyung Yi; Fiscal Year: 2008
    ..abstract_text> ..