Genomes and Genes
Gene Symbol: Il6
Description: interleukin 6
Alias: Il-6, interleukin-6, B-cell hybridoma growth factor, interleukin HP-1
Publications206 found, 100 shown here
- Costunolide inhibits production of tumor necrosis factor-alpha and interleukin-6 by inducing heme oxygenase-1 in RAW264.7 macrophagesH O Pae
Medicinal Resources Research Institute, Wonkwang University, Iksan, Chonbug, Republic of Korea
Inflamm Res 56:520-6. 2007..7 macrophages...
- Localized inflammation in peripheral tissue signals the CNS for sickness response in the absence of interleukin-1 and cyclooxygenase-2 in the blood and brainH Zhang
Institute of Behavior Medicine, 3132 Postle Hall, 305 West 12th Avenue, Ohio State University, Columbus, OH 43210 1094, USA
Neuroscience 157:895-907. 2008..These findings suggest that local inflammation can activate the CNS via pathways distinguishable from those mediating systemic inflammation-induced CNS activation...
- Comparison of the effects of aging and IL-6 on the hepatic inflammatory response in two models of systemic injury: scald injury versus i.p. LPS administrationChristian R Gomez
The Burn and Shock Trauma Institute, Department of Surgery, and Immunology and Aging Program, Loyola University Medical Center, Maywood, IL 60153, USA
Shock 31:178-84. 2009..Our results suggest that the nature of the insult will determine the degree of remote injury in aged animals. In addition, the role of IL-6 as a contributing factor of tissue injury may be insult specific...
- Role of interleukin-6 in bleomycin-induced lung inflammatory changes in miceFumitake Saito
Division of Pulmonary Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
Am J Respir Cell Mol Biol 38:566-71. 2008..These results indicate that IL-6 may play an important role in the pathogenesis of BLM-induced lung injury and subsequent fibrotic changes...
- Hypoxic preconditioning induces elevated expression of stanniocalcin-1 in the heartJohan A Westberg
Department of Pathology, Haartman Institute, University of Helsinki, Finland
Am J Physiol Heart Circ Physiol 293:H1766-71. 2007..Our findings indicate that IL-6-induced expression of STC-1 is one molecular mechanism behind the ischemic tolerance generated by HOPC in the heart...
- The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cellsIvaylo I Ivanov
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Cell 126:1121-33. 2006..Together, these studies suggest that RORgammat is a key regulator of immune homeostasis and highlight its potential as a therapeutic target in inflammatory diseases...
- IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathwaysLiang Zhou
The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
Nat Immunol 8:967-74. 2007..IL-6 therefore orchestrates a series of 'downstream' cytokine-dependent signaling pathways that, in concert with TGF-beta, amplify RORgammat-dependent differentiation of T(H)-17 cells...
- The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cellsOliver Dienz
Department of Medicine Immunobiology Program, University of Vermont, Burlington, VT 05405, USA
J Exp Med 206:69-78. 2009..Thus, IL-6 promotes antibody production by promoting the B cell helper capabilities of CD4(+) T cells through increased IL-21 production. IL-6 could therefore be a potential coadjuvant to enhance humoral immunity...
- Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cellsHelga Ellingsgaard
Clinic for Endocrinology, Diabetes and Metabolism and Department Biomedicine, University Hospital Basel, Basel, Switzerland
Nat Med 17:1481-9. 2011..This previously unidentified endocrine loop implicates IL-6 in the regulation of insulin secretion and suggests that drugs modulating this loop may be useful in type 2 diabetes...
- Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestineMichael H Shaw
Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
J Exp Med 209:251-8. 2012..Thus, commensal-induced IL-1β production is a critical step for sT(H)17 differentiation in the intestine, which may have therapeutic implications for T(H)17-mediated pathologies...
- IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responsesZ Xing
Immunology and Infection Program, Department of Pathology, McMaster University, Hamilton, Ontario, L8N 3Z5 Canada
J Clin Invest 101:311-20. 1998....
- Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinaseAndrew L Carey
Cellular and Molecular Metabolism Laboratory, School of Medical Sciences, Royal Melbourne Institute of Technology RMIT University, Australia
Diabetes 55:2688-97. 2006..Our results demonstrate that acute IL-6 treatment enhances insulin-stimulated glucose disposal in humans in vivo, while the effects of IL-6 on glucose and fatty acid metabolism in vitro appear to be mediated by AMPK...
- Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjectsVictoria Rotter
Department of Internal Medicine, Lundberg Laboratory for Diabetes Research, The Sahlgrenska Academy, Goteborg University, SE 413 45 Goteborg, Sweden
J Biol Chem 278:45777-84. 2003..We conclude that IL-6 can play an important role in insulin resistance in man and, furthermore, that it may act in concert with other cytokines that also are up-regulated in adipose cells in insulin resistance...
- Liver failure and defective hepatocyte regeneration in interleukin-6-deficient miceD E Cressman
Department of Genetics and Medicine, University of Pennsylvania School of Medicine, 705a Stellar Chance, 422 Curie Boulevard, Philadelphia, PA 19104 6145, USA
Science 274:1379-83. 1996....
- Interleukin 6 is required for the development of collagen-induced arthritisT Alonzi
Istituto Ricerche di Biologia Molecolare P Angeletti, 00040 Pomezia, Rome, Italy
J Exp Med 187:461-8. 1998..These results are discussed in the light of the present knowledge of cytokine networks in chronic inflammatory disorders and suggest that IL-6 receptor antagonists might be beneficial for the treatment of RA...
- TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathologyMandy J McGeachy
Schering Plough Biopharma, Palo Alto, California 94304, USA
Nat Immunol 8:1390-7. 2007Studies have shown that transforming growth factor-beta (TGF-beta) and interleukin 6 (IL-6) are required for the lineage commitment of pathogenic IL-17-producing T helper cells (T(H)-17 cells)...
- Impaired immune and acute-phase responses in interleukin-6-deficient miceM Kopf
Max Planck Institut fur Immunbiologie, Freiburg, Germany
Nature 368:339-42. 1994..We conclude that IL-6 production induced by injury or infection is an important in vivo SOS signal which coordinates activities of liver cells, macrophages and lymphocytes...
- Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletionV Poli
Istituto di Ricerche di Biologia Molecolare P Angeletti, Rome, Italy
EMBO J 13:1189-96. 1994..These findings indicate that IL-6 plays an important role in the local regulation of bone turnover and, at least in mice, appears to be essential for the bone loss caused by estrogen deficiency...
- IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cellsLiying Guo
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 106:13463-8. 2009....
- Tolerogenic function of Blimp-1 in dendritic cellsSun Jung Kim
Center for Autoimmune and Musculoskeletal Diseases, Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
J Exp Med 208:2193-9. 2011..This study is of particular interest because a polymorphism of Blimp-1 associates with SLE...
- Vascular endothelial growth factor is a key mediator in the development of T cell priming and its polarization to type 1 and type 17 T helper cells in the airwaysYou Sun Kim
Department of Life Science, Postech Biotech Center, Pohang University of Science and Technology, Pohang, Republic of Korea
J Immunol 183:5113-20. 2009..These findings indicate that VEGF produced by LPS plays a key role in activation of naive T cells and subsequent polarization to Th1 and Th17 cells...
- The inflammatory response in interleukin-1 beta-deficient mice: comparison with other cytokine-related knock-out miceG Fantuzzi
Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA
J Leukoc Biol 59:489-93. 1996....
- Interleukin 6 is important for survival after partial hepatectomy in miceAlex Blindenbacher
Department of Research, University Hospital Basel, Basel, Switzerland
Hepatology 38:674-82. 2003The response to partial hepatectomy (PH) is impaired in interleukin 6 (IL-6)-deficient mice...
- Heat shock transcription factor 1 inhibits expression of IL-6 through activating transcription factor 3Ryosuke Takii
Department of Biochemistry and Molecular Biology, Yamaguchi University School of Medicine, Ube, Japan
J Immunol 184:1041-8. 2010..These results demonstrate a novel inhibitory pathway for inflammatory cytokines...
- Exacerbation of CNS inflammation and neurodegeneration by systemic LPS treatment is independent of circulating IL-1β and IL-6Carol L Murray
School of Biochemistry and Immunology, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
J Neuroinflammation 8:50. 2011..Here we investigated whether inhibition of systemic cytokine synthesis using the anti-inflammatory steroid dexamethasone-21-phosphate was sufficient to block any or all of these responses...
- Defective inflammatory response in interleukin 6-deficient miceE Fattori
Istituto di Ricerche di Biologia Molecolare IRBM P Angeletti, Pomezia, Roma
J Exp Med 180:1243-50. 1994..b>Interleukin 6 (IL-6) is considered an important mediator of the inflammatory response, together with IL-1 and tumor necrosis ..
- The importance of IL-1 beta and TNF-alpha, and the noninvolvement of IL-6, in the development of monoclonal antibody-induced arthritisTakashi Kagari
Biological Research Laboratories, Sankyo Co, Ltd, Tokyo, Japan
J Immunol 169:1459-66. 2002..Because arthritis was also developed in SCID mice, the development of arthritis in the Ab-induced mice model is due to a mechanism that does not involve T or B cells...
- IL-6 regulates neutrophil trafficking during acute inflammation via STAT3Ceri A Fielding
Department of Nephrology, School of Medicine, Cardiff University, Cardiff, United Kingdom
J Immunol 181:2189-95. 2008....
- Interleukin-6 regulates pancreatic alpha-cell mass expansionHelga Ellingsgaard
Division of Endocrinology and Diabetes and Center for Integrated Human Physiology, University Hospital of Zurich, 8091 Zurich, Switzerland
Proc Natl Acad Sci U S A 105:13163-8. 2008....
- Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacitiesFouad Eddahri
Laboratoire de Physiologie Animale, Universite Libre de Bruxelles, Brussels, Belgium
Blood 113:2426-33. 2009..Collectively, these data indicate that the ability to provide B-cell help is regulated by IL-6/IL-21 through STAT3 activation, independently of Th1, Th2, Th17, or follicular helper T cell (T(FH)) differentiation...
- Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine modelSatoshi Matsumoto
Yakult Central Institute for Microbiological Research, Tokyo, Japan
J Immunol 184:1543-51. 2010..Treatment with soluble gp130Fc significantly reduced the CApC. IL-6 trans-signaling in epithelial cells induced by macrophage-derived IL-6/sIL-6R alpha plays a crucial role in the development of CAC...
- Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistanceV B Matthews
Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, PO Box 6492, St Kilda Road Central, Melbourne, 3008, Vic, Australia
Diabetologia 53:2431-41. 2010..We aimed to determine whether global deletion of Il6 in mice (Il6 (-/-)) results in standard chow-induced and high-fat diet (HFD)-induced obesity, hepatosteatosis, ..
- Interleukin-6-deficient mice develop mature-onset obesityVille Wallenius
Research Center for Endocrinology and Metabolism, The Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden
Nat Med 8:75-9. 2002..We investigated the impact of loss of IL-6 on body composition in mice lacking the gene encoding IL-6 (Il6-/- mice) and found that they developed mature-onset obesity that was partly reversed by IL-6 replacement...
- Role of IL-6 and TNF in thermoregulation and survival during sepsis in miceL R Leon
Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87185, USA
Am J Physiol 275:R269-77. 1998..The enhanced lethality of CLP-treated female mice supports a role for sex steroids during sepsis...
- Role of interleukin-6 for LV remodeling and survival after experimental myocardial infarctionMartin Fuchs
Department of Cardiology and Angiology, Medizinische Hochschule Hannover, Germany
FASEB J 17:2118-20. 2003....
- Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-betaLili Xu
Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 178:6725-9. 2007..They thus have important implications to our understanding of regulatory T cell function and their possible therapeutic use...
- Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 productionWillscott E Naugler
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Cancer Center, University of California, San Diego, CA 93093, USA
Science 317:121-4. 2007..We propose that estrogen-mediated inhibition of IL-6 production by KCs reduces liver cancer risk in females, and these findings may be used to prevent HCC in males...
- IL-6 deficiency in mice neither impairs induction of metabolic genes in the liver nor affects blood glucose levels during fasting and moderately intense exerciseL Fritsche
Department of Internal Medicine, Division of Pathobiochemistry and Clinical Chemistry, University of Tuebingen, Otfried Mueller Strasse 10, 72076 Tuebingen, Germany
Diabetologia 53:1732-42. 2010..IL-6 has been implicated in the regulation of gluconeogenic genes, but the results are contradictory and the relevance of IL-6 for fasting- and exercise-induced hepatic glucose production is not clear...
- Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptorMolly M McFarland-Mancini
Department of Cancer and Cell Biology, Vontz Center for Molecular Studies, University of Cincinnati, Cincinnati, OH 45267, USA
J Immunol 184:7219-28. 2010..These findings underscore a deeper complexity for IL-6Ralpha function in inflammation than has been recognized previously...
- Interleukin-6 promotes pulmonary emphysema associated with apoptosis in miceSaleela M Ruwanpura
Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Monash University, 27 31 Wright Street, Clayton 3168, Victoria, Australia
Am J Respir Cell Mol Biol 45:720-30. 2011..We propose that the discrete targeting of IL-6 signaling may provide an effective therapeutic strategy against human lung disease...
- Particulate matter-induced lung inflammation increases systemic levels of PAI-1 and activates coagulation through distinct mechanismsG R Scott Budinger
Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
PLoS ONE 6:e18525. 2011..We sought to determine whether exposure of mice to PM increases the levels of PAI-1, a major regulator of thrombolysis, via a similar or distinct mechanism...
- Interleukin-6/glycoprotein 130-dependent pathways are protective during liver regenerationTorsten Wuestefeld
Department of Gastroenterology, Hepatology, and Endocrinology, Medizinische Hochschule Hannover, 30625 Hannover, Germany
J Biol Chem 278:11281-8. 2003After tissue loss the liver has the unique capacity to restore its mass by hepatocyte proliferation. Interleukin-6 (IL6)-deficient mice show a lack in DNA synthesis after partial hepatectomy (PH)...
- Feeding, exploratory, anxiety- and depression-related behaviors are not altered in interleukin-6-deficient male miceArtur H Swiergiel
Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, 71130 3932, USA
Behav Brain Res 171:94-108. 2006..It is concluded that the lack of IL-6 is not associated with substantial alterations in several different mouse behaviors, and in the responses to restraint, IL-1beta, IL-6 and LPS...
- Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 inductionHideki Ogura
Laboratory of Developmental Immunology, Graduate School of Frontier Biosciences, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
Immunity 29:628-36. 2008..Because this mechanism also enhanced experimental autoimmune encephalomyelitis (EAE) in wild-type mice, it may be a general etiologic process underlying other Th17 cell-mediated autoimmune diseases...
- Flk-1+ mesenchymal stem cells aggravate collagen-induced arthritis by up-regulating interleukin-6B Chen
Institute of Basic Medical Sciences and School of Basic Medicine, Center of Excellence in Tissue Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Clin Exp Immunol 159:292-302. 2010..When Flk-1(+) MSCs are used for patients, we should be cautious about subjects with rheumatoid arthritis...
- Interleukin (IL)-6 gene expression in the central nervous system is necessary for fever response to lipopolysaccharide or IL-1 beta: a study on IL-6-deficient miceZ Chai
Department of Neurochemistry and Neurotoxicology, Arrhenius Laboratories for Natural Sciences, Stockholm University, Sweden
J Exp Med 183:311-6. 1996..These results suggest that central IL-6 is a necessary component of the fever response to both endogenous (IL-1 beta) and exogenous (LPS) pyrogens in mice and that IL-6 acts downstream from both peripheral and central IL-1 beta...
- Chronic exposure to interleukin-6 causes hepatic insulin resistance in micePeter J Klover
Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Diabetes 52:2784-9. 2003..These data suggest that chronic IL-6 treatment selectively impairs hepatic insulin signaling in vivo, further supporting a role for IL-6 in hepatic insulin resistance of obesity...
- Interleukin-6 facilitates lipopolysaccharide-induced disruption in working memory and expression of other proinflammatory cytokines in hippocampal neuronal cell layersNathan L Sparkman
Laboratory of Integrative Immunology and Behavior, Department of Animal Sciences, University of Illinois, Urbana, Illinois 61801, USA
J Neurosci 26:10709-16. 2006..Collectively, these data suggest that humoral and neural immune-to-brain communication pathways are intact in IL-6-deficient mice but that, in the absence of IL-6, the central cytokine compartment is hyporesponsive...
- Phospholipase Cgamma2 is critical for Dectin-1-mediated Ca2+ flux and cytokine production in dendritic cellsShengli Xu
Laboratory of Immunology, Bioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore 138668
J Biol Chem 284:7038-46. 2009..Thus, our data indicate that pattern recognition receptors such as Dectin-1 could elicit Ca2+ signaling and that PLCgamma2 is a critical player in the Dectin-1 signal transduction pathway...
- In vivo regulation of Bcl6 and T follicular helper cell developmentAmanda C Poholek
Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA
J Immunol 185:313-26. 2010..These data increase our understanding of Bcl6 regulation in T(FH) cells and their differentiation in vivo and identifies a new surface marker that may be functionally relevant in this subset...
- Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritisHong Ji
Section on Immunology and Immunogenetics, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
J Exp Med 196:77-85. 2002..The variability in the requirement for TNF-alpha, reminiscent of that observed in treated rheumatoid arthritis patients, did not appear genetically programmed but related instead to subtle environmental changes...
- Role of interleukin-6 in mortality from and physiologic response to sepsisDaniel G Remick
Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0602, USA
Infect Immun 73:2751-7. 2005..We tested whether interleukin 6 knockout (IL-6KO) mice were more susceptible to sepsis mortality induced by cecal ligation and puncture...
- IL-6 is required for airway mucus production induced by inhaled fungal allergensWendy A Neveu
Department of Medicine, Division of Immunobiology, University of Vermont, Burlington, VT 05405, USA
J Immunol 183:1732-8. 2009..Thus, IL-6 is a key regulator of specific hallmark features of allergic airway inflammation and it could be a potential target for pulmonary diseases that are associated with goblet cell metaplasia and mucus hypersecretion...
- Role of host cytokine responses in the pathogenesis of avian H5N1 influenza viruses in miceKristy J Szretter
Influenza Branch MS G 16, Division of Viral and Ricksettial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
J Virol 81:2736-44. 2007..These results suggest that TNF-alpha may contribute to morbidity during H5N1 influenza virus infection, while IL-1 may be important for effective virus clearance in nonlethal H5N1 disease...
- Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in miceJiusong Sun
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 117:3359-68. 2007....
- In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cellsMatthias Lochner
Laboratory of Lymphoid Tissue Development, Centre National de la Recherche Scientifique URA1961, Institut Pasteur, Paris 75724, France
J Exp Med 205:1381-93. 2008....
- Reciprocal regulation of IL-6 and IL-10 balance by HGF via recruitment of heme oxygenase-1 in macrophages for attenuation of liver injury in a mouse model of endotoxemiaMiyuki Kamimoto
Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, Suita, Osaka, 565 0871, Japan
Int J Mol Med 24:161-70. 2009..Based on the current data, we conclude that up-regulation of HO-1 plays an important role in HGF-mediated hepatoprotection during endotoxemia, by favoring production of IL-10 over IL-6...
- Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitmentM Romano
Istituto Ricerche Farmacologiche Mario Negri, Milan, Italy
Immunity 6:315-25. 1997..Hence, in vivo and in vitro evidence supports the concept that the IL-6 system plays an unexpected positive role in local inflammatory reactions by amplifying leukocyte recruitment...
- Hepatocellular hyperplasia, plasmacytoma formation, and extramedullary hematopoiesis in interleukin (IL)-6/soluble IL-6 receptor double-transgenic miceP Schirmacher
Institute of Pathology, University of Mainz, Germany
Am J Pathol 153:639-48. 1998..Interestingly, the complex of IL-6 and the soluble interleukin 6 receptor (sIL-6R) activates target cells that do not express the membrane-bound IL-6R and therefore cannot ..
- IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophagesHideo Yasukawa
Institute of Molecular Medicine and Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0641, USA
Nat Immunol 4:551-6. 2003..SOCS3 specifically prevents activation of STAT3 by IL-6 but not IL-10. Taken together, these data indicate that SOCS3 selectively blocks signaling by IL-6, thereby preventing its ability to inhibit LPS signaling...
- Interleukin-1 and its biologically related cytokinesC A Dinarello
Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02111
Adv Immunol 44:153-205. 1989
- Cardiotrophin-1 defends the liver against ischemia-reperfusion injury and mediates the protective effect of ischemic preconditioningMaría Iñiguez
Division of Hepatology and Gene Therapy, Center for Applied Medical Research CIMA, Clinica Universitaria and Medical School, University of Navarra, Pamplona 31008, Spain
J Exp Med 203:2809-15. 2006..In conclusion, CT-1 is an essential endogenous defense of the liver against I/R and is a key mediator of the protective effect induced by IP...
- Opposing roles of gp130-mediated STAT-3 and ERK-1/ 2 signaling in liver progenitor cell migration and proliferationGeorge C T Yeoh
UWA Centre for Medical Research, The Western Australian Institute for Medical Research, Perth, Australia
Hepatology 45:486-94. 2007..For the first time, we have dissected the gp130-mediated signaling pathways, which influence liver progenitor oval cell proliferation...
- Hypoxic preconditioning induces neuroprotective stanniocalcin-1 in brain via IL-6 signalingJohan A Westberg
Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland
Stroke 38:1025-30. 2007..We originally reported expression of mammalian STC-1 in brain neurons and showed that STC-1 guards neurons against hypercalcemic and hypoxic damage...
- STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteriaLobelia Samavati
Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA
Mol Immunol 46:1867-77. 2009..This inhibition did not affect caspase-1 activation. These results highlight the complex role of STAT3 in cytokine production and the key role of STAT3 tyrosine phosphorylation in IL-1beta and IL-6 production in response to inflammation...
- Regulation of tissue inhibitor of metalloproteinase-1 in fibroblasts and acute phase proteins in hepatocytes in vitro by mouse oncostatin M, cardiotrophin-1, and IL-6C D Richards
Department of Pathology, McMaster University, Hamilton, Ontario, Canada
J Immunol 159:2431-7. 1997..These results also suggest that mOSM is an important cytokine in inflammation, through modulation of fibroblast function as well as hepatocyte responses...
- Production of IL-1 receptor antagonist by hepatocytes is regulated as an acute-phase protein in vivoC Gabay
Division of Rheumatology, University Hospital of Geneva, Geneva, Switzerland
Eur J Immunol 31:490-9. 2001..In contrast, local production of IL-1Ra is independent of IL-6. Taken together, these results indicate that IL-1Ra is produced by the liver as an acute-phase protein in vivo...
- IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancerSergei Grivennikov
Laboratory of Gene Regulation and Signal Transduction, UCSD School of Medicine, University of California San Diego, La Jolla, CA 92093 0723, USA
Cancer Cell 15:103-13. 2009..Proinflammatory cytokines have been suggested to regulate preneoplastic growth during CAC tumorigenesis. Interleukin 6 (IL-6) is a multifunctional NF-kappaB-regulated cytokine that acts on epithelial and immune cells...
- Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammationVanesa Esteban
Cellular Biology in Renal Diseases Laboratory, Fundacion Jimenez Diaz, Universidad Autonoma Madrid, Madrid, Spain
PLoS ONE 4:e5406. 2009..Therefore, the blockade of the NF-kappaB-activating properties of the receptor Mas could be a new strategy in the therapy of failing kidney...
- Annexin-1 regulates macrophage IL-6 and TNF via glucocorticoid-induced leucine zipperYuan H Yang
Centre for Inflammatory Diseases, Department of Medicine, Monash University, Clayton, Victoria, Australia
J Immunol 183:1435-45. 2009..These data confirm ANXA1 as a key inhibitor of macrophage cytokine expression and identify GILZ as a previously unrecognized mechanism of the anti-inflammatory effects of ANXA1...
- Interleukin-6 enhances matrix metalloproteinase-14 expression via the RAF-mitogen-activated protein kinase kinase-extracellular signal-regulated kinase 1/2-activator protein-1 pathwayMin Feng
Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Shandong University Qilu Hospital, Jinan, Shandong, China
Clin Exp Pharmacol Physiol 37:162-6. 2010..4. These findings suggest a novel molecular pathway for inflammation-associated ECM dysregulation, which may account for atherosclerotic plaque rupture...
- IL-6 production is positively regulated by two distinct Src homology domain 2-containing tyrosine phosphatase-1 (SHP-1)-dependent CCAAT/enhancer-binding protein β and NF-κB pathways and an SHP-1-independent NF-κB pathway in lipopolysaccharide-stimulated bDorothy Rego
Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario KIH 8M5, Canada
J Immunol 186:5443-56. 2011....
- Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6Luc Vallières
Laboratories of Neuronal Structure and Function, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
J Neurosci 22:486-92. 2002..These findings suggest that long-term exposure of the brain to proinflammatory mediators such as IL-6, as is seen in certain degenerative disorders and infections, can interfere with adult neurogenesis...
- IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady stateMika Nishihara
Laboratory of Developmental Immunology, Graduate School of Frontier Biosciences and Graduate School of Medicine, Osaka University, Osaka, Japan
Int Immunol 19:695-702. 2007..Therefore, blockade of IL-6-gp130-STAT3 pathway in CD4+ T cells could be a good target for controlling unwanted Th17-mediated immune responses including autoimmune diseases...
- gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesisJulia Bollrath
2nd Department of Medicine, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
Cancer Cell 15:91-102. 2009....
- Establishment of the role of IL-6 and TNF receptor 1 using gene knockout miceH Bluethmann
Department of Biology, F Hoffmann La Roche Ltd, Basel, Switzerland
J Leukoc Biol 56:565-70. 1994..Results for interferon-- and interferon-gamma receptor-deficient mice are included for comparison...
- Interleukin-6 overexpression cannot generate serious disorders in severe combined immunodeficiency miceA Katsume
Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co Ltd, Komakado 1 135, Gotemba shi, Shizuoka, 412, Japan
Clin Immunol Immunopathol 82:117-24. 1997....
- Caspase-1 regulates the inflammatory process leading to autoimmune demyelinationR Furlan
Experimental Neuroimmunotherapy Unit, Department of Biotechnology, San Raffaele Scientific Institute, Milan, Italy
J Immunol 163:2403-9. 1999..These results indicate that caspase-1 plays an important role in the early stage of the immune-mediated inflammatory process leading to EAE, thus representing a possible therapeutic target in the acute phase of relapsing remitting MS...
- HMGB-1, a DNA-binding protein with cytokine activity, induces brain TNF and IL-6 production, and mediates anorexia and taste aversionDavide Agnello
Laboratory of Neuroimmunology, Mario Negri Institute for Pharmacological Research, 20157 Milano, Italy
Cytokine 18:231-6. 2002..In a model of endotoxemia, passive immunization with anti-HMG-1 antibodies attenuated the development of hypophagia, indicating that HMG-1 is a mediator of sickness behaviour associated with endotoxemia...
- Expression of the hematopoietic stem cell antigen Sca-1 (LY-6A/E) in liver sinusoidal endothelial cells: possible function of Sca-1 in endothelial cellsGonzalo Luna
Laboratorio de Patología Celular y Molecular, Centro de Medicina Experimental, Instituto Venezolano de Investigaciones Cientificas IVIC, Caracas 1020 A, Venezuela
Stem Cells Dev 13:528-35. 2004..These results suggest that Sca-1 may participate in several clinical conditions such as angiogenesis and inflammation...
- IL-6 is not required for parathyroid hormone stimulation of RANKL expression, osteoclast formation, and bone loss in miceCHARLES A O'BRIEN
Division of Endocrinology and Metabolism, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Am J Physiol Endocrinol Metab 289:E784-93. 2005..These results demonstrate that IL-6 is not required for the osteoclast formation and bone loss that accompanies continuous elevation of PTH...
- IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidinElizabeta Nemeth
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles UCLA, Los Angeles, California, USA
J Clin Invest 113:1271-6. 2004....
- Ambient particulate matter accelerates coagulation via an IL-6-dependent pathwayGokhan M Mutlu
Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
J Clin Invest 117:2952-61. 2007..These results provide a potential mechanism linking ambient particulate matter exposure and thrombotic events...
- Long-term consequences of interleukin-6 overexpression in transgenic miceC Woodroofe
European Molecular Biology Laboratory, Heidelberg, Germany
DNA Cell Biol 11:587-92. 1992..These results indicate that the side effects of long-term treatment with IL-6 are relatively moderate, and that IL-6 might be used to mediate the expression of heterologous genes in the context of functional studies...
- IgG1 plasmacytosis in interleukin 6 transgenic miceS Suematsu
Division of Immunology, Osaka University, Japan
Proc Natl Acad Sci U S A 86:7547-51. 1989b>Interleukin 6 (IL-6) has been suggested to be involved in the pathogenesis of polyclonal and monoclonal plasma cell abnormalities...
- Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomasJ Van Snick
Proc Natl Acad Sci U S A 83:9679-83. 1986....
- Development of progressive kidney damage and myeloma kidney in interleukin-6 transgenic miceE Fattori
Department of Genetics of IRBM P Angeletti, Pomezia, Roma, Italy
Blood 83:2570-9. 1994..The pathogenetic role of IL-6 overproduction and of the resulting serum protein overload in the kidney damage is discussed...
- Accelerated Nerve Regeneration in Mice by upregulated expression of interleukin (IL) 6 and IL-6 receptor after traumaH Hirota
Institute for Molecular and Cellular Biology, Osaka University, Japan
J Exp Med 183:2627-34. 1996In this study we aimed to examine a role for interleukin 6 (IL-6) and its receptor (IL-6R) in peripheral nerve regeneration in vivo...
- Defective development of pristane-oil-induced plasmacytomas in interleukin-6-deficient BALB/c miceG Lattanzio
Dipartimento di Patologia Umana e Medicina Sociale, Universita di Chieti, Italy
Am J Pathol 151:689-96. 1997....
- Interleukin 6 plays a key role in the development of antigen-induced arthritisS Ohshima
Department of Medicine III, Osaka University Medical School, Suita City, Osaka 565 0871, Japan
Proc Natl Acad Sci U S A 95:8222-6. 1998..Taken together, these results indicate that IL-6 may play a key role in the development of AIA at the inductive as well as the effector phase, and the blockade of IL-6 is possibly beneficial in the treatment of rheumatoid arthritis...
- Interleukin 6 dependence of anti-DNA antibody production: evidence for two pathways of autoantibody formation in pristane-induced lupusH B Richards
Department of Medicine, Thurston Arthritis Research Center, University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill 27599 7280, USA
J Exp Med 188:985-90. 1998..This may reflect the differential IL-6 dependence of the two responses...
- Interleukin 6 influences germinal center development and antibody production via a contribution of C3 complement componentM Kopf
Basel Institute for Immunology, CH 4005 Basel, Switzerland
J Exp Med 188:1895-906. 1998..These findings reveal that the germinal center produces and uses molecules of the innate immune system, evolutionarily pirating them in order to optimally generate high affinity antibody responses...
- IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cellsE B Samoilova
Institute for Human Gene Therapy and Department of Molecular and Cellular Engineering, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
J Immunol 161:6480-6. 1998..These results strongly suggest that IL-6 plays a crucial role in the activation and differentiation of autoreactive T cells in vivo and that blocking IL-6 function can be an effective means to prevent EAE...
- Strongly compromised inflammatory response to brain injury in interleukin-6-deficient miceM Penkowa
Institute of Medical Anatomy, Section C, The Panum Institute, University of Copenhagen, Denmark
Glia 25:343-57. 1999..Furthermore, our results suggest IL-6 is important for neuroprotection and the induction of GM-CSF and MT expression. The opposing effect of IL-6 on MT-I+II and MT-III levels in the damaged brain suggests MT isoform-specific functions...
- Interleukin-6 is a needed proinflammatory cytokine in the prolonged neural activity and transcriptional activation of corticotropin-releasing factor during endotoxemiaL Vallières
Department of Anatomy and Physiology, Laval University, Sainte Foy, Quebec, Canada
Endocrinology 140:3890-903. 1999....
- Expression and self-regulatory function of cardiac interleukin-6 during endotoxemiaH Saito
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555, USA
Am J Physiol Heart Circ Physiol 279:H2241-8. 2000..Thus cardiac IL-6, expressed mainly by nonmyocardial cells via IL-1beta action during endotoxemia, is likely to suppress expression of proinflammatory mediators and to regulate itself via a negative feedback mechanism...
- IL-6 transgenic mouse model for extraosseous plasmacytomaAlexander L Kovalchuk
Laboratory of Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 99:1509-14. 2002..These findings provide a unique model of extramedullary PCT for studies on pathogenesis and treatment and suggest a previously unappreciated role for IL-6 in the genesis of germinal center-derived lymphomas...
- Resistance to experimental autoimmune myasthenia gravis in IL-6-deficient mice is associated with reduced germinal center formation and C3 productionCaishu Deng
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 1070, USA
J Immunol 169:1077-83. 2002..The data provide the first direct genetic evidence for a key role of IL-6 in the autoimmune response to AChR and in EAMG pathogenesis...
- Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant miceNiall C Tebbutt
Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
Nat Med 8:1089-97. 2002..We propose a model whereby mucosal wound healing depends solely on activation of STAT1/3, whereas gastric hyperplasia ensues when the coordinated activation of the STAT1/3 and SHP2-Ras-ERK pathways is disrupted...
- Interleukin-6-deficient mice resist development of autoimmune myocarditis associated with impaired upregulation of complement C3Urs Eriksson
Department of Internal Medicine, Medical ICU, University Hospital, Basel, Switzerland
Circulation 107:320-5. 2003..Interleukin (IL)-6 regulates various aspects of the immune response. In the context of heart diseases, it has been recognized as a prognostic factor for dilated cardiomyopathy, which often results from myocarditis...
- Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytesJoseph J Senn
Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, New York 14642, USA
J Biol Chem 278:13740-6. 2003..These data suggest that induction of SOCS-3 in liver may be an important mechanism of IL-6-mediated insulin resistance...
- Host Immunoregulation of Response to Antileishmanial ChemotherapyHenry Murray; Fiscal Year: 2007..abstract_text> ..
- Role of p38 MAPK in IL-4-induced IL-6 expression in vascular endotheliumYongwoo Lee; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- NEURONAL ACTIONS OF HOST FACTORS IN NEUROAIDSDONNA GRUOL; Fiscal Year: 2005..The overall design will address effects of both acute and chronic chemokine exposure on neuronal cell function and will include examination of two distinct classes of neurons, excitatory glutamatergic and inhibitory GABAergic neurons. ..
- Immune Pathways as Prerequisites for Adjuvants' EfficacyGeorge Hui; Fiscal Year: 2004....
- IN VIVO REGULATION OF IL6 AND IL6R GENE EXPRESSIONCHARLES O BRIEN; Fiscal Year: 2002..Finally, cis-acting regulatory elements in the IL-6 promoter that are the targets for estrogen and PTH actions in vivo will be identified. ..
- HSP25 and HSP20 Regulation in Skeletal Muscle AdaptKIMBERLY HUEY; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Pattern Recognition Molecule Mindin As AdjuvantYou Wen He; Fiscal Year: 2007..Third, Mindin fused DNA plasmids will be examined for their efficacy in protecting influenza virus infection. [unreadable] [unreadable]..
- IL-6 Regulation of Hippocampal Synaptic FunctionDonna L Gruol; Fiscal Year: 2010..The proposed studies focus on this issue as it relates to CNS disorders. ..
- HTLV deregulation of NF-kappaB2 p100 processing in tumorGutian Xiao; Fiscal Year: 2010..The completion of the proposed studies may lead to new therapeutic strategies for p100 processing-associated human diseases. ..
- Prevent HIV protease inhibitor-induced atherosclerosis by BerberineHUIPING ROSE ZHOU; Fiscal Year: 2010..Completion of these specific aims will help identify and establish new therapeutic strategies for HIV infection. ..
- CXC CHEMOKINES AND LIVER REGENERATIONLisa Colletti; Fiscal Year: 2009..To investigate this hypothesis, we will examine specific MIP-2-related mechanisms of hepatocyte proliferation and apoptosis following 70% hepatectomy, as well as IP-10's modulating effects in this system. ..
- p38 MAP kinase in early thymocyte developmentMercedes Rincon; Fiscal Year: 2008..abstract_text> ..
- Matrix Metalloproteinases, Exercise, and Muscle DamageDavid Allen; Fiscal Year: 2008..Finally, subjects will be genotyped for known functional MMP promoter polymorphisms, which will be correlated with MMP levels and muscle damage and soreness following eccentric exercise. ..
- Investigation of hepcidin in mammalian iron homeostasisCindy Roy; Fiscal Year: 2008..Future work will focus on investigating the role of the hepcidin receptor and its homologs in iron metabolism and the anemia of chronic disease ..
- Role of Matrix Metalloproteinase-2 in Liver FibrosisMeena Bansal; Fiscal Year: 2007..Findings from these investigations may lead to novel approaches to the treatment of chronic fibrosing liver disease. [unreadable] [unreadable]..
- Gender differences in liver IL-6R expressionRANDLE GALLUCCI; Fiscal Year: 2007..By exposing ethanol- consuming rats to IL-6R agonists, it should be possible to correlate damage with receptor activation. [unreadable] [unreadable] [unreadable]..
- Il-6 type cytokine protection from hyperoxic lung injuryAaron Waxman; Fiscal Year: 2007..abstract_text> ..
- Extracellular Matrix Protein in Innate ImmunityYou Wen He; Fiscal Year: 2007..Results from this proposal will provide novel insights on the mechanisms of the innate immune response and may have implication for clinical treatment of septic shock and other microbe caused diseases. [unreadable] [unreadable]..
- ORPHAN NUCLEAR RORgammat IN THYMOCYTE DIFFERENTIATIONYou Wen He; Fiscal Year: 2006..In addition, results from this application will also provide insights for the role of ROR-gamma-t in tumorigenesis. ..
- CYTOKINE/CHEMOKINE ACTIONS ON DEVELOPING CNS NEURONSDONNA GRUOL; Fiscal Year: 2002....
- ROLE OF PKD IN LEUKOCYTE ACTIVATION BY CPG DNAAe Kyung Yi; Fiscal Year: 2002..This proposed study would enhance our understanding of how CpG motifs in bacterial DNA break immune tolerance and contribute to chrome inflammatory autoimmune diseases such as arthritis. ..
- HOST IMMUNOREGULATION OF ANTILEISHMANIAL CHEMOTHERAPYHenry Murray; Fiscal Year: 2005..And Aim 3: Characterize immunostimulation in AmB's efficacy, and in recrudescent infection following AmB therapy, pinpoint the likely cytokine-driven T cell mechanism which prevents post-treatment relapse. ..
- Lung epithelium-derived IL-6 in CD4+ T cell immune resp*Mercedes Rincon; Fiscal Year: 2004..abstract_text> ..
- Role of arginine deficiency in pathogenesis of lupusMinoru Satoh; Fiscal Year: 2004..abstract_text> ..
- Role of Galectin-4 in ColitisAtsushi Mizoguchi; Fiscal Year: 2008..These studies will not only enhance understanding of the pathogenic mechanisms of IBD but also provide important information to develop new therapeutic approaches for human IBD. ..
- UCP5-- Balancing Metabolism and Oxidation in Aging BrainLAURA DUGAN; Fiscal Year: 2004....
- Identification of an IL-6 induced keratinocyte motogenRANDLE GALLUCCI; Fiscal Year: 2008..The results of these experiments will hopefully lead to the eventual development of a useful treatment for chronic wounds. ..
- Cell-targeting peptide nucleic acids for hormone-refractory prostate cancerBeverly Barton; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- SCF in liver repair after hepatectomy or toxic injuryLisa Colletti; Fiscal Year: 2006..These studies will help to elucidate novel mechanisms in SCF-mediated hepatocyte protection and regeneration in a clinically relevant liver resection and toxicity model. ..
- HIV Protease Inhibitors, the Unfolded Protein Response and AtherosclerosisHuiping Zhou; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- IL-6 regulation of matrix degradation in liver fibrosisMeena Bansal; Fiscal Year: 2006..MMP-2 in vivo; (4) To test the importance of MMP-2 in liver injury in vivo by administering MMP-2 inhibitors to IL6 +/+ and-/-mice with acute and chronic liver injury...
- MECHANISMS OF NEUROPROTECTION BY C60 DERIVATIVESLAURA DUGAN; Fiscal Year: 2001....
- Monocyte Biology and BiodefenseDOUGLAS DREVETS; Fiscal Year: 2005..These data will then catalyze development of rational therapies to improve host defenses against severe and overwhelming infection by category A and B intracellular bacterial pathogens. ..
- Somatic Ca2+ Signaling in CNS NeuronsDONNA GRUOL; Fiscal Year: 2007..However, the general principles identified by the studies will also contribute significantly to our understanding of the role of activity-dependent gene expression during development in other CNS neuronal types. [unreadable] [unreadable]..
- Induction of immunological paralysis by CpG DNAAe Kyung Yi; Fiscal Year: 2008..abstract_text> ..