Il4

Summary

Gene Symbol: Il4
Description: interleukin 4
Alias: BSF-1, Il-4, interleukin-4, B-cell IgG differentiation factor, B-cell growth factor 1, B-cell stimulatory factor 1, IGG1 induction factor, lymphocyte stimulatory factor 1
Species: mouse

Top Publications

  1. pmc T follicular helper cells differentiate from Th2 cells in response to helminth antigens
    Arielle Glatman Zaretsky
    Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Exp Med 206:991-9. 2009
  2. ncbi Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter
    M Mohrs
    Howard Hughes Medical Institute, Departments of Medicine and Microbiology Immunology, University of California, San Francisco 94143, USA
    Immunity 15:303-11. 2001
  3. ncbi Generation and analysis of interleukin-4 deficient mice
    R Kuhn
    Institute for Genetics, University of Cologne, Germany
    Science 254:707-10. 1991
  4. pmc Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion
    Padraic G Fallon
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Exp Med 203:1105-16. 2006
  5. pmc An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response
    M G Chiaramonte
    Schistosomiasis Immunology and Pathology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 104:777-85. 1999
  6. ncbi Essential role of Stat6 in IL-4 signalling
    K Takeda
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Nature 380:627-30. 1996
  7. pmc Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity
    J A Rankin
    Pulmonary and Critical Care Medicine, VA Connecticut Health Care System, West Haven 06516, USA
    Proc Natl Acad Sci U S A 93:7821-5. 1996
  8. ncbi IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis
    J F Urban
    United States Department of Agriculture, Beltsville, Maryland 20705, USA
    Immunity 8:255-64. 1998
  9. ncbi CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasis
    Antonella Mencacci
    Department of Experimental Medicine and Biochemical Science, University of Perugia, Perugia, Italy
    J Immunol 169:3180-90. 2002
  10. pmc IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells
    Liying Guo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:13463-8. 2009

Research Grants

Detail Information

Publications215 found, 100 shown here

  1. pmc T follicular helper cells differentiate from Th2 cells in response to helminth antigens
    Arielle Glatman Zaretsky
    Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Exp Med 206:991-9. 2009
    ..The relationship of TFH cells to the Th2 lineage was confirmed when TFH cells were found to develop from CXCR5(-) PD-1(-) IL-4/GFP(+) CD4(+) T cells after their transfer into naive mice and antigen challenge in vivo...
  2. ncbi Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter
    M Mohrs
    Howard Hughes Medical Institute, Departments of Medicine and Microbiology Immunology, University of California, San Francisco 94143, USA
    Immunity 15:303-11. 2001
    ..Transferred EGFP(+) CD4(+) T cells from infected animals conferred protection against Nippostrongylus to immunodeficient mice. These mice will provide a valuable reagent for assessing immunity in vivo...
  3. ncbi Generation and analysis of interleukin-4 deficient mice
    R Kuhn
    Institute for Genetics, University of Cologne, Germany
    Science 254:707-10. 1991
    ..Thus, some but not all of the in vitro properties of IL-4 are critical for the physiology of the immune system in vivo...
  4. pmc Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion
    Padraic G Fallon
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Exp Med 203:1105-16. 2006
    ..We demonstrate that these IL-25-regulated cells appear rapidly in the draining lymph nodes, implicating them as a source of type 2 cytokines during initiation of worm expulsion...
  5. pmc An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response
    M G Chiaramonte
    Schistosomiasis Immunology and Pathology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 104:777-85. 1999
    ..Thus, our findings provide evidence that IL-13 inhibitors may be of general therapeutic benefit in preventing damaging tissue fibrosis resulting from Th2-dominated inflammatory responses...
  6. ncbi Essential role of Stat6 in IL-4 signalling
    K Takeda
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    Nature 380:627-30. 1996
    ..These findings agreed with those obtained in IL-4 deficient mice or using antibodies to IL-4 and the IL-4 receptor. We conclude that Stat6 plays a central role in exerting IL-4 mediated biological responses...
  7. pmc Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity
    J A Rankin
    Pulmonary and Critical Care Medicine, VA Connecticut Health Care System, West Haven 06516, USA
    Proc Natl Acad Sci U S A 93:7821-5. 1996
    ....
  8. ncbi IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis
    J F Urban
    United States Department of Agriculture, Beltsville, Maryland 20705, USA
    Immunity 8:255-64. 1998
    ..Additional observations made in the course of these experiments demonstrate that Stat6 signaling is not required for IL-4 enhancement of IgG1 production and actually inhibits IL-4-induction of mucosal mastocytosis...
  9. ncbi CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasis
    Antonella Mencacci
    Department of Experimental Medicine and Biochemical Science, University of Perugia, Perugia, Italy
    J Immunol 169:3180-90. 2002
    ..These data indicate that alternatively activated PMN expressing CD80 may adversely affect Th1-dependent resistance in fungal infections...
  10. pmc IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells
    Liying Guo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:13463-8. 2009
    ....
  11. doi Cyclooxygenase-2 in mucosal DC mediates induction of regulatory T cells in the intestine through suppression of IL-4
    F Broere
    Department of Molecular Cell Biology and Immunology, VU Medical Center, Amsterdam, The Netherlands
    Mucosal Immunol 2:254-64. 2009
    ..These data provide crucial insights into the mechanisms driving de novo Tr-cell induction and tolerance in the intestine...
  12. pmc Alternative activation of macrophages by IL-4 impairs phagocytosis of pathogens but potentiates microbial-induced signalling and cytokine secretion
    Audrey Varin
    Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
    Blood 115:353-62. 2010
    ..These findings are relevant to host defense in mixed infections within a Th2 microenvironment and shed light on immunologic functions associated with alternative priming and full activation of macrophages...
  13. ncbi Interleukin-4 but not interleukin-10 protects against spontaneous and recurrent type 1 diabetes by activated CD1d-restricted invariant natural killer T-cells
    Qing Sheng Mi
    Autoimmunity Diabetes Group, Robarts Research Institute, 1400 Western Road, London, Ontario N6G 2V4, Canada
    Diabetes 53:1303-10. 2004
    ..Our data identify an important role for IL-4 in the protection against type 1 diabetes by activated iNKT cells, and these findings have important implications for cytokine-based therapy of type 1 diabetes and islet transplantation...
  14. pmc Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor
    Bart Everts
    Department of Parasitology, Leiden University Medical Center, 2333 ZA Leiden, Netherlands
    J Exp Med 209:1753-67, S1. 2012
    ..These experiments reveal an unrecognized pathway involving MR and interference with protein synthesis that conditions DCs for Th2 priming...
  15. pmc Enhanced pulmonary histopathology induced by respiratory syncytial virus (RSV) challenge of formalin-inactivated RSV-immunized BALB/c mice is abrogated by depletion of interleukin-4 (IL-4) and IL-10
    M Connors
    Respiratory Viruses Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 68:5321-5. 1994
    ..It is possible that this process played a role in enhanced disease observed in infants and children immunized with FI-RSV...
  16. ncbi CNS-derived interleukin-4 is essential for the regulation of autoimmune inflammation and induces a state of alternative activation in microglial cells
    Eugene D Ponomarev
    BloodCenter of Wisconsin, Blood Research Institute, Milwaukee, Wisconsin 53201 2178, USA
    J Neurosci 27:10714-21. 2007
    ..Macrophages that have undergone alternative activation have been shown to be important in tissue repair; thus, our results suggest a new role for microglial cells in the regulation of inflammation in the CNS...
  17. ncbi Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
    M H Kaplan
    Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Immunity 4:313-9. 1996
    ..These results demonstrate that, despite the existence of multiple signaling pathways activated by IL-4, Stat6 is essential for mediating responses to IL-4 lymphocytes...
  18. pmc Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation
    M Stein
    Sir William Dunn School of Pathology, Oxford, United Kingdom
    J Exp Med 176:287-92. 1992
    ..b>Interleukin 4 (IL-4), a Th-2 lymphocyte product, upregulates major histocompatibility class II antigen expression but ..
  19. ncbi Endogenous IL-4 is necessary for effective drug therapy against visceral leishmaniasis
    J Alexander
    Department of Immunology, University of Strathclyde, Glasgow, GB
    Eur J Immunol 30:2935-43. 2000
    ..These results demonstrate that IL-4 has an important role in effective anti-leishmanial chemotherapy which seems to be related to modulation of IFN-gamma production...
  20. ncbi IL-33 induces antigen-specific IL-5+ T cells and promotes allergic-induced airway inflammation independent of IL-4
    Mariola Kurowska-Stolarska
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow United Kingdom
    J Immunol 181:4780-90. 2008
    ..Thus, we demonstrate here that, in the presence of Ag, IL-33 induces IL-5-producing T cells and promotes airway inflammation independent of IL-4...
  21. ncbi Cutting edge: early IL-4 production governs the requirement for IL-27-WSX-1 signaling in the development of protective Th1 cytokine responses following Leishmania major infection
    David Artis
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    J Immunol 172:4672-5. 2004
    ..major. Thus, the requirement for WSX-1 signaling in Th type 1 cell differentiation is restricted to conditions in which IL-4 is produced...
  22. ncbi Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation
    Nicole M Haynes
    Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 179:5099-108. 2007
    ....
  23. ncbi IL-13 overexpression predisposes to anaphylaxis following antigen sensitization
    P G Fallon
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    J Immunol 166:2712-6. 2001
    ..The systemic regulation of this response makes these mice an important resource for studying atopic responses...
  24. pmc Nonredundant roles for CD1d-restricted natural killer T cells and conventional CD4+ T cells in the induction of immunoglobulin E antibodies in response to interleukin 18 treatment of mice
    Tomohiro Yoshimoto
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    J Exp Med 197:997-1005. 2003
    ..These findings indicate that NKT cells might be the major source of IL-4 in response to IL-18 administration and that conventional CD4+ T cells demonstrate their helper function in the presence of NKT cells...
  25. ncbi CRTH2 plays an essential role in the pathophysiology of Cry j 1-induced pollinosis in mice
    Rie Nomiya
    Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Immunol 180:5680-8. 2008
    ..These results suggest that the PGD(2)-CRTH2 interaction is elevated following sensitization and plays a proinflammatory role in the pathophysiology of allergic rhinitis, especially pollinosis in mice...
  26. pmc IL-4 and TGF-beta 1 counterbalance one another while regulating mast cell homeostasis
    Matthew R Macey
    Virginia Commonwealth University, Biology Department, Box 842012, Richmond, VA 23284 2012, USA
    J Immunol 184:4688-95. 2010
    ..Dysregulation of this balance may impact allergic disease and be amenable to targeted therapy...
  27. doi The enhancer HS2 critically regulates GATA-3-mediated Il4 transcription in T(H)2 cells
    Shinya Tanaka
    Laboratory for Signal Network, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Yokohama, Japan
    Nat Immunol 12:77-85. 2011
    ..Here we identify the DNase I-hypersensitive site 2 (HS2) element located in the second intron of the interleukin 4 locus (Il4) as a critical enhancer strictly controlled by GATA-3 binding...
  28. doi Blockade of B7-H1 (programmed death ligand 1) enhances humoral immunity by positively regulating the generation of T follicular helper cells
    Emily Hams
    Institute of Molecular Medicine, St James s Hospital, Trinity College Dublin, Dublin 8, Ireland
    J Immunol 186:5648-55. 2011
    ..This finding has direct implications for investigations examining the feasibility of therapeutically manipulating this pathway and reveals new insights into the regulation of the humoral immune response...
  29. doi Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells
    Nicola Gagliani
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy
    Nat Med 19:739-46. 2013
    ..The use of these markers makes it feasible to track Tr1 cells in vivo and purify Tr1 cells for cell therapy to induce or restore tolerance in subjects with immune-mediated diseases...
  30. ncbi Interleukin-4 biases differentiation of B cells from Trypanosoma cruzi-infected mice and restrains their fratricide: role of Fas ligand down-regulation and MHC class II-transactivator up-regulation
    E V Acosta Rodriguez
    Inmunologia, Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Ciudad Universitaria, Haya de la Torre Medina Allende, Cordoba 5000, Argentina
    J Leukoc Biol 73:127-36. 2003
    ..Accordingly, a marked up-regulation of the "FasL gene repressor" class II transactivator was observed, suggesting that this would be one mechanism underlying the IL-4-mediated FasL down-regulation...
  31. ncbi Pulmonary tuberculosis in BALB/c mice with non-functional IL-4 genes: changes in the inflammatory effects of TNF-alpha and in the regulation of fibrosis
    Rogelio Hernandez-Pando
    Experimental Pathology Laboratory, Department of Pathology, Instituto Nacional de la Nutricion Salvador Zubiran, Mexico City, Mexico
    Eur J Immunol 34:174-83. 2004
    ..In conclusion, the findings suggest that IL-4 has modestly detrimental effects on the antibacterial efficacy of the Th1 response, and larger effects on the toxicity of TNF-alpha, and on fibrosis...
  32. doi Remission of CVB3-induced viral myocarditis by in vivo Th2 polarization via hydrodynamics-based interleukin-4 gene transfer
    Zhenggang Jiang
    Department of Immunology, Institute for Immunobiology, Shanghai Medical College of Fudan University, Shanghai, PR China
    J Gene Med 10:918-29. 2008
    ..In the present study, interleukin (IL)-4 was over-expressed by hydrodynamics-based gene transfection (HGT) to induce the in vivo Th2 bias and evaluate the influence of Th polarization on the pathogenesis of CVB3-myocaditis...
  33. pmc IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells
    Valerie Dardalhon
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, USA
    Nat Immunol 9:1347-55. 2008
    ..Thus IL-9(+)IL-10(+) T cells lack suppressive function and constitute a distinct population of helper-effector T cells that promote tissue inflammation...
  34. pmc Unique and overlapping gene expression patterns driven by IL-4 and IL-13 in the mouse lung
    Christina C Lewis
    Division of Immunobiology, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio 45229, USA
    J Allergy Clin Immunol 123:795-804.e8. 2009
    ..Although these 2 cytokines share signaling components, the molecular mechanisms by which they mediate different phases of the allergic asthmatic response remain elusive...
  35. doi IL-4 is proangiogenic in the lung under hypoxic conditions
    Kazuyo Yamaji-Kegan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    J Immunol 182:5469-76. 2009
    ..In conclusion, IL-4 has proangiogenic properties in the lung under hypoxic conditions via the VEGF pathway, and this is independent of the STAT6 pathway...
  36. doi Role of IL-4 in aversion induced by food allergy in mice
    Luana Pereira Antunes Dourado
    Departamento de Morfologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Cell Immunol 262:62-8. 2010
    ..These results indicate that production of IL-4 and specific IgE/IgG1 antibodies correlate with aversion to antigen induced by food allergy in mice...
  37. pmc Regulation of learning and memory by meningeal immunity: a key role for IL-4
    Noel C Derecki
    Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    J Exp Med 207:1067-80. 2010
    ..These findings might lead to the development of new immune-based therapies for cognitive impairment associated with immune decline...
  38. pmc Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150)
    Isharat Yusuf
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, School of Medicine, La Jolla, CA 92037, USA
    J Immunol 185:190-202. 2010
    ..These data illustrate complexities of SAP-dependent SLAM family receptor signaling, revealing a prominent role for SLAM receptor ligation in IL-4 production by GC CD4 T cells but not in T(FH) cell and GC T(FH) cell differentiation...
  39. pmc IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity
    Roberto R Ricardo-Gonzalez
    Division of Endocrinology, Metabolism and Gerontology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 107:22617-22. 2010
    ....
  40. ncbi Natural IgE production in the absence of MHC Class II cognate help
    Kathy D McCoy
    Institute of Experimental Immunology, Department of Pathology, Universitatsspital, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Immunity 24:329-39. 2006
    ..The pathway of spontaneous IgE production is not inhibited by regulatory T cells and increases with age to constitute significant serum concentrations, even in naive animals...
  41. pmc Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation
    Nicolas Charles
    Laboratory of Immune Cell Signaling, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 30:533-43. 2009
    ..Our findings demonstrate that basophil-expressed Lyn kinase exerts regulatory control on Th2 cell differentiation and function...
  42. ncbi A critical role for IL-13 in resistance to intestinal nematode infection
    A J Bancroft
    School of Biological Science, University of Manchester, United Kingdom
    J Immunol 160:3453-61. 1998
    ..The IL-13 KO mouse had a separate phenotype to that of the IL-4 KO mouse, suggesting that both IL-4 and IL-13 play important yet different roles in mediating immunity to intestinal helminths...
  43. ncbi Differential functions of IL-4 receptor types I and II for dendritic cell maturation and IL-12 production and their dependency on GM-CSF
    Manfred B Lutz
    Department of Dermatology and Institute of Clinical Microbiology, Immunology, and Hygiene, University of Erlangen Nuremberg, Erlangen, Germany
    J Immunol 169:3574-80. 2002
    ....
  44. ncbi CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: a role for IL-4
    Anthony Lyons
    Trinity College Institute for Neuroscience, Physiology Department, Trinity College, Dublin 2, Ireland
    J Neurosci 27:8309-13. 2007
    ..Our findings provide the first demonstration of a role for IL-4 in modulating CD200 expression and suggest a mechanism for regulation of microglial activation in the intact CNS under inflammatory conditions...
  45. ncbi IL-10 and the dangers of immune polarization: excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis
    K F Hoffmann
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 164:6406-16. 2000
    ....
  46. pmc Differential regulation of IL-4Ralpha expression by antigen versus cytokine stimulation characterizes Th2 progression in vivo
    Georgia Perona-Wright
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 184:615-23. 2010
    ..Together these data reveal a tightly controlled program of changing IL-4 responsiveness that characterizes the initiation, amplification, and restriction of a Th2 response in vivo...
  47. ncbi Gastrointestinal nematode expulsion in IL-4 knockout mice is IL-13 dependent
    A J Bancroft
    School of Biological Sciences, University of Manchester, GB
    Eur J Immunol 30:2083-91. 2000
    ..muris from the gut. Moreover, the present data highlight the functional importance of gender and background strain in interpretation of studies using gene-targeted animals...
  48. ncbi IL-4-dependent effector phase in autoimmune exocrinopathy as defined by the NOD.IL-4-gene knockout mouse model of Sjögren's syndrome
    J B Brayer
    Department of Oral Biology, University of Florida College of Dentistry, Gainesville, FL 32610, USA
    Scand J Immunol 54:133-40. 2001
    ..IL-4-/- mice to express detectable anti-M3R autoantibodies, the precise mechanism of how IL-4 influences the development of autoimmune xerostomia remains speculative...
  49. ncbi Interleukin-13 mediates airways hyperreactivity through the IL-4 receptor-alpha chain and STAT-6 independently of IL-5 and eotaxin
    M Yang
    Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
    Am J Respir Cell Mol Biol 25:522-30. 2001
    ..Furthermore, IL-13-induced AHR, eosinophilia, and mucus production are critically dependent on the IL-4Ralpha chain and STAT-6...
  50. ncbi Protection from fluorescein isothiocyanate-induced fibrosis in IL-13-deficient, but not IL-4-deficient, mice results from impaired collagen synthesis by fibroblasts
    Jill E Kolodsick
    Department of Internal Medicine, Graduate Program in Immunology, Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 172:4068-76. 2004
    ..Thus, IL-13 mediates its profibrotic actions through direct effects on fibroblast production of extracellular matrix...
  51. ncbi Suppressor of cytokine signaling-1 regulates inflammatory bowel disease in which both IFNgamma and IL-4 are involved
    Takatoshi Chinen
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Gastroenterology 130:373-88. 2006
    ..However, the role of SOCS1 in inflammatory bowel diseases (IBDs) has not been clarified. To determine the role of SOCS1 in colitis, we generated SOCS1/T-cell receptor alpha (TCRalpha) double knockout (DKO) mice...
  52. pmc Mast cell IL-4 expression is regulated by Ikaros and influences encephalitogenic Th1 responses in EAE
    Gregory D Gregory
    Department of Microbiology Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 3010, USA
    J Clin Invest 116:1327-36. 2006
    ..Independent of the activation mode, MCs from Th1-prone C57BL/6 mice exhibited a more robust Il4 response than did the Th2-prone strain Balb/c...
  53. doi Decreased neuronal CD200 expression in IL-4-deficient mice results in increased neuroinflammation in response to lipopolysaccharide
    Anthony Lyons
    Trinity College Institute for Neuroscience, Trinity College, Dublin 2, Ireland
    Brain Behav Immun 23:1020-7. 2009
    ..These findings suggest that the neuromodulatory effect of IL-4, and in particular its capacity to maintain microglia in a quiescent state, may result from its ability to upregulate CD200 expression on neurons...
  54. pmc IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion
    Vasilena Gocheva
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genes Dev 24:241-55. 2010
    ..Together, these data establish IL-4 as an important regulator, and cathepsin proteases as critical mediators, of the cancer-promoting functions of TAMs...
  55. ncbi Allergen-induced airway inflammation and bronchial responsiveness in wild-type and interleukin-4-deficient mice
    G Brusselle
    Department of Respiratory Diseases, University Hospital Ghent, Belgium
    Am J Respir Cell Mol Biol 12:254-9. 1995
    ..In conclusion, these data indicate that repeated allergen exposure in sensitized mice induces airway inflammation and bronchial hyperresponsiveness, and that IL-4 plays a predominant role in the pathogenesis of both phenomena...
  56. pmc PU.1 and GATA: components of a mast cell-specific interleukin 4 intronic enhancer
    G Henkel
    Department of Microbiology Immunology, Oregon Health Sciences University, Portland 97201
    Proc Natl Acad Sci U S A 91:7737-41. 1994
    b>Interleukin 4 (IL-4), a critical immunoregulatory cytokine, is produced by a subset of T lymphocytes and cells of the mast cell/basophil lineage...
  57. ncbi IL-4 secreted from individual naive CD4+ T cells acts in an autocrine manner to induce Th2 differentiation
    Nancy Noben-Trauth
    Department of Immunology, The George Washington University, Washington 20037, USA
    Eur J Immunol 32:1428-33. 2002
    ..Thus, each founder cell or one or more of its early daughters can produce sufficient IL-4 to drive Th2 differentiation. This indicates that autocrine IL-4 production by naive CD4 T cells can drive the appearance of Th2 cells...
  58. pmc Cutaneous immunization rapidly activates liver invariant Valpha14 NKT cells stimulating B-1 B cells to initiate T cell recruitment for elicitation of contact sensitivity
    Regis A Campos
    Department of Medicine, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520 8013, USA
    J Exp Med 198:1785-96. 2003
    ....
  59. pmc Immune regulation of protease-activated receptor-1 expression in murine small intestine during Nippostrongylus brasiliensis infection
    Aiping Zhao
    Department of Medicine and the Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 175:2563-9. 2005
    ..N. brasiliensis-induced changes in PAR-1 function and expression were seen in IL-4-deficient mice, but not in IL-13- or STAT6-deficient mice, indicating the dependence of IL-13 on the STAT6 signaling pathway independent of IL-4...
  60. ncbi FGFR-1 regulates angiogenesis through cytokines interleukin-4 and pleiotrophin
    Peetra U Magnusson
    Department of Genetics and Pathology, Uppsala University, The Rudbeck Laboratory, Uppsala, Sweden
    Blood 110:4214-22. 2007
    ..We conclude that FGFR-1 negatively regulates endothelial cell function by altering the balance of modulatory cytokines...
  61. pmc A new mechanism for inhalational priming: IL-4 bypasses innate immune signals
    Anna M Dittrich
    Department for Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA
    J Immunol 181:7307-15. 2008
    ..Our findings bring new mechanistic knowledge to the phenomenon of polysensitization and primary sensitization in asthma...
  62. doi IL4 blockade of inducible regulatory T cell differentiation: the role of Th2 cells, Gata3 and PU.1
    Suzana Hadjur
    Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK
    Immunol Lett 122:37-43. 2009
    ..transcription factor Foxp3, but iTreg differentiation is blocked by high concentrations of the Th2 cytokine IL4. However, whether IL4 can antagonise Foxp3 induction in more physiological settings remains to be addressed...
  63. doi ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1)
    Zhenhu Li
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Nat Immunol 12:178-85. 2011
    ..Our data identify a previously unknown function of ECM1 in regulating T(H)2 cell migration through control of KLF2 and S1P(1) expression...
  64. pmc Interleukin 4 induces the apoptosis of mouse microglial cells by a caspase-dependent mechanism
    Javier A Soria
    Centro de Investigaciones en Bioquímica Clínica e Inmunología CONICET, Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Haya de la Torre y Medina Allende, Ciudad Universitaria, Córdoba X5000HUA, Argentina
    Neurobiol Dis 43:616-24. 2011
    ..Our observations demonstrate a novel function of IL-4 in regulating the survival of microglial cells, which may have important significance in reduction of undesired inflammatory responses in the CNS...
  65. pmc 8-Oxoguanine-DNA glycosylase 1 deficiency modifies allergic airway inflammation by regulating STAT6 and IL-4 in cells and in mice
    Guoping Li
    Department of Biochemistry and Molecular Biology, University of North Dakota, Grand Forks, ND 58203 9037, USA
    Free Radic Biol Med 52:392-401. 2012
    ..OGG-1 may affect the levels of oxidative stress and proinflammatory cytokines during asthmatic conditions. OGG-1 deficiency negatively regulates allergen-induced airway inflammatory response...
  66. pmc In vivo expression of interleukin-1 beta (IL-1 beta), IL-2, IL-4, IL-6, tumour necrosis factor-alpha and interferon-gamma in the fetal murine thymus
    J Deman
    Laboratory of Pathological Anatomy, University of Liege, Belgium
    Immunology 89:152-7. 1996
    ..This supports the hypothesis that cytokines play a rote in T-cell lymphopoiesis...
  67. ncbi Down-regulation of caveolin-1, an inhibitor of transforming growth factor-beta signaling, in acute allergen-induced airway remodeling
    Claude Jourdan Le Saux
    Department of Cell and Molecular Biology, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96813, USA
    J Biol Chem 283:5760-8. 2008
    ..This study demonstrates a previously unknown modulation of TGF-beta signaling by IL-4, via cav1, suggesting novel therapeutic targets for controlling the effects of TGF-beta and thereby ameliorating pathological airway remodeling...
  68. ncbi IFN-alpha/beta signaling is required for polarization of cytokine responses toward a protective type 1 pattern during experimental cryptococcosis
    Carmelo Biondo
    Dipartimento di Patologia e Microbiologia Sperimentale, Universita degli Studi di Messina, Messina, Italy
    J Immunol 181:566-73. 2008
    ..neoformans. Our data demonstrate that type I IFN signaling is required for polarization of cytokine responses toward a protective type I pattern during cryptococcal infection...
  69. pmc Apoptotic cells activate NKT cells through T cell Ig-like mucin-like-1 resulting in airway hyperreactivity
    Hyun Hee Lee
    Division of Immunology and Allergy, Department of Pediatrics, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 185:5225-35. 2010
    ..Furthermore, these results provide evidence for a novel innate pathway that results in airway hyperreactivity and may help to explain how TIM-1 and NKT cells regulate asthma...
  70. ncbi IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2
    R M Stack
    Committee on Developmental Biology, University of Chicago, IL 60637
    J Immunol 152:5723-33. 1994
    ..Additionally, these findings support our previous findings that an alternative ligand for CD28 and CTLA4 is important in providing costimulation...
  71. ncbi The role of IL-4, IL-10, and TNF-alpha in the immune suppression induced by ultraviolet radiation
    J M Rivas
    Department of Immunology, University of Texas, M D Anderson Cancer Center Houston 77030
    J Leukoc Biol 56:769-75. 1994
    ..Because anti-IL-4 and anti-IL-10 did not block the activity of the UV Ts that regulate contact hypersensitivity, their effects appear to be mediated by a different mechanism...
  72. ncbi Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4
    M Kondo
    Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan
    Science 262:1874-7. 1993
    ..These results suggest that the IL-2 receptor gamma chain is functionally involved in the IL-4 receptor complex...
  73. ncbi IL-4-regulated enteropathy in an intestinal nematode infection
    C E Lawrence
    Division of Infection and Immunity, Institute of Biomedical and Life Sciences, University of Glasgow, GB
    Eur J Immunol 28:2672-84. 1998
    ....
  74. pmc Differential effects of the absence of interferon-gamma and IL-4 in acute graft-versus-host disease after allogeneic bone marrow transplantation in mice
    W J Murphy
    SAIC Frederick, Division of Basic Science, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    J Clin Invest 102:1742-8. 1998
    ..These results therefore indicate, with regard to the TH1/ TH2 cytokine paradigm, the absence of a TH1-type cytokine can be deleterious in acute GVHD, whereas absence of a TH2 cytokine can be protective...
  75. ncbi Reduced IL-4-, lipopolysaccharide-, and IFN-gamma-induced MHC class II expression in mice lacking class II transactivator due to targeted deletion of the GTP-binding domain
    Y Itoh-Lindstrom
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill 27599, USA
    J Immunol 163:2425-31. 1999
    ..These findings demonstrate a requirement for CIITA in IFN-gamma-, IL-4-, and endotoxin-induced MHC class II expression as well as the possibility of rare CIITA-independent MHC class II expression...
  76. pmc Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4
    C A Herrick
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Invest 105:765-75. 2000
    ..These data demonstrate a marked difference in the IL-4 dependence of Th2 responses generated at two anatomic sites of natural allergen encounter and identify the skin as a particularly potent site for Th2 sensitization...
  77. ncbi The progression of chronic tuberculosis in the mouse does not require the participation of B lymphocytes or interleukin-4
    J Turner
    Department of Microbiology, Colorado State University, Fort Collins, CO 80523, USA
    Exp Gerontol 36:537-45. 2001
    ....
  78. ncbi Interleukin-4-mediated protection of primary B cells from apoptosis through Stat6-dependent up-regulation of Bcl-xL
    Andrea L Wurster
    Department of Immunology and Infectious Diseases, School of Public Health, Harvard Medical School, Boston, MA 02115, USA
    J Biol Chem 277:27169-75. 2002
    ..Although it is well established that interleukin 4 (IL-4) is a potent anti-apoptotic cytokine for B lymphocytes, little is known about the IL-4-induced molecular ..
  79. pmc In TH2 cells the Il4 gene has a series of accessibility states associated with distinctive probabilities of IL-4 production
    Liying Guo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, and Cancer Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:10623-8. 2002
    ..Among six TH2 clones prepared from homozygous or heterozygous mice in which Gfp replaced the first exon of Il4, a range of patterns of CpG methylation in the Il4/Il13 locus was observed correlating with the degree of ..
  80. ncbi Basal chromatin modification at the IL-4 gene in helper T cells
    Jane L Grogan
    Howard Hughes Medical Institute, Department of Medicine and Microbiology Immunology, University of California, San Francisco, CA 94143 0654, USA
    J Immunol 171:6672-9. 2003
    ..Hyperacetylation of nonexpressed genes may serve to mark lineage-specific loci for rapid expression and further modification...
  81. pmc Interleukin-4 (IL-4) and IL-10 collude in vaccine failure for novel exacerbatory antigens in murine Leishmania major infection
    Mark T M Roberts
    Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrooke s Hospital, Hills Rd, Cambridge CB2 2XY, United Kingdom
    Infect Immun 73:7620-8. 2005
    ..major, while having an intrinsic capacity to exacerbate disease in the context of otherwise T helper 1-promoting DNA vaccine delivery, can be rendered protective by the removal of functional IL-10...
  82. ncbi Morphine induces CD4+ T cell IL-4 expression through an adenylyl cyclase mechanism independent of the protein kinase A pathway
    Sabita Roy
    Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 175:6361-7. 2005
    ..We also demonstrate that chronic morphine treatment increases anti-CD3/CD28 Ab-induced IL-4 promoter activity and IL-4 immunoprotein expression through a p38 MAPK-dependent, but protein kinase A- and Erk1/Erk2-independent, mechanism...
  83. ncbi Role of interleukin-4 and prostaglandin E2 in Leishmania amazonensis infection of BALB/c mice
    Elisalva T Guimarães
    Centro de Pesquisas Goncalo Moniz, FIOCRUZ, Rua Waldemar Falcao 121, 40296 710 Salvador, Bahia, Brazil
    Microbes Infect 8:1219-26. 2006
    ..The lesions of indomethacin-treated groups contained mostly macrophages without vacuoles and small or absent necrotic areas. These results indicate that IL-4 and PGE(2) are susceptibility factors to L. amazonensis infection...
  84. ncbi The corneal response to infection with Staphylococcus aureus in the absence of interleukin-4
    Nerida Cole
    Institute for Eye Research, University of New South Wales, Sydney, NSW 2052, Australia
    Immunol Cell Biol 85:333-7. 2007
    ..This information may lead to the development of novel therapeutic strategies potentially improving the prognosis for infection of this unique avascular site...
  85. ncbi The progression of inflammation parallels the dermal angiogenesis in a keratin 14 IL-4-transgenic model of atopic dermatitis
    Lin Chen
    Department of Dermatology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Microcirculation 15:49-64. 2008
    ..In conclusion, IL-6 and IFN-gamma may play important roles in upregulation of VEGF-A, along with other pro-angiogenic factors, to induce dermal microvascular angiogenesis...
  86. ncbi Murine IL-4 is able to signal via chimeric human IL-4Ralpha/mouse gamma-chain receptor
    Elmarie Myburgh
    University of Cape Town, Health Science Faculty, Institute of Infectious Disease and Molecular Medicine, Division Immunology, Cape Town, South Africa
    Mol Immunol 45:1327-36. 2008
    ..brasiliensis infections. Together, these data demonstrate that mIL-4 triggered the hIL-4Ralpha/mgammac chimeric receptor in vivo...
  87. pmc PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling
    XiaoQing Lu
    Sylvester Comprehensive Cancer Center, Division of Hematology Oncology, Department of Medicine, Monash University, Victoria, Australia
    Blood 112:4098-108. 2008
    ..complexes with phosphorylated STAT6 in a cellular context and endogenous PTP1B and STAT6 interacted in an interleukin 4 (IL-4)-inducible manner. We delineate a new negative regulatory loop of IL-4-JAK-STAT6 signaling...
  88. pmc Impaired apoptotic cell clearance in CGD due to altered macrophage programming is reversed by phosphatidylserine-dependent production of IL-4
    Ruby F Fernandez-Boyanapalli
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Blood 113:2047-55. 2009
    ..Alternative activation with interleukin 4 (IL-4) normalized CGD macrophage efferocytosis, whereas classical activation by lipopolysaccharide (LPS) plus ..
  89. pmc Host natural killer T cells induce an interleukin-4-dependent expansion of donor CD4+CD25+Foxp3+ T regulatory cells that protects against graft-versus-host disease
    Asha B Pillai
    Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, CA 38105, USA
    Blood 113:4458-67. 2009
    ....
  90. pmc Ovalbumin-induced plasma interleukin-4 levels are reduced in ceramide kinase-deficient DO11.10 RAG1-/- mice
    Satoru Niwa
    Novartis Institutes for BioMedical Research, Brunnerstrasse 59, A 1235 Vienna, Austria
    Lipids Health Dis 9:1. 2010
    ..However, the importance of CERK to TH2 cell biology will have to be investigated further because in a model of asthma, which is TH2-cell driven, Cerk-/- mice responded like wild-type animals...
  91. pmc IL-4 directs both CD4 and CD8 T cells to produce Th2 cytokines in vitro, but only CD4 T cells produce these cytokines in response to alum-precipitated protein in vivo
    Karine Serre
    MRC Centre for Immune Regulation, The IBR, School of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Mol Immunol 47:1914-22. 2010
    ....
  92. doi IFN-gamma inhibits IL-4-induced type 2 cytokine expression by CD8 T cells in vivo and modulates the anti-tumor response
    Simon H Apte
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    J Immunol 185:998-1004. 2010
    ..These findings may explain the anomalies in the reported functional phenotype of type 2 polarized CD8 T cells...
  93. pmc Sustained IL-4 exposure leads to a novel pathway for hemophagocytosis, inflammation, and tissue macrophage accumulation
    Joshua D Milner
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases NIAID, Bethesda, MD 20892, USA
    Blood 116:2476-83. 2010
    ..These data describe a novel pathophysiologic pathway for erythrophagocytosis in the context of tissue macrophage accumulation and inflammation involving elevations in IL-4 and alternative macrophage activation...
  94. doi Neutralization of IL-4 reverses the nonresponsiveness of CD4+ T cells to regulatory T-cell induction in non-responder mouse strains
    Jun Wang
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Mol Immunol 48:137-46. 2010
    ....
  95. doi Hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELMalpha) increases lung inflammation and activates pulmonary microvascular endothelial cells via an IL-4-dependent mechanism
    Kazuyo Yamaji-Kegan
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Immunol 185:5539-48. 2010
    ..These findings suggest that IL-4 signaling may play a significant role in HIMF-induced lung inflammation and vascular remodeling...
  96. ncbi PU.1 expression delineates heterogeneity in primary Th2 cells
    Hua Chen Chang
    Department of Microbiology and Immunology, and Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Immunity 22:693-703. 2005
    ..Thus, the expression of PU.1 in subsets of Th2 cells establishes a defined cytokine profile and contributes towards establishing the spectrum of cytokine production observed in Th2 populations...
  97. pmc Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs
    Damien Bresson
    Department of Developmental Immunology 3, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Clin Invest 116:1371-81. 2006
    ..Since Tregs act site-specifically, this strategy should also be expected to reduce the potential for systemic side effects...
  98. ncbi A pivotal role for interleukin-4 in atorvastatin-associated neuroprotection in rat brain
    Rachael M Clarke
    Trinity College Institute for Neuroscience, Physiology Department, Trinity College, Dublin 2, Ireland
    J Biol Chem 283:1808-17. 2008
    ..We propose that the primary effect of atorvastatin is to increase IL-4, which antagonizes the effects of IFNgamma, the associated increase in microglial activation, and the subsequent cascade of events...
  99. ncbi Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells
    B A Witthuhn
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Nature 370:153-7. 1994
    ..Jak-3 activation requires the serine-rich, membrane-proximal domain of the interleukin-2 receptor beta-chain, but does not require the acidic domain that is required for association and activation of Src family kinases...
  100. pmc Interleukin-4 causes delayed virus clearance in influenza virus-infected mice
    T M Moran
    Department of Microbiology, Mount Sinai School of Medicine, New York 10029, USA
    J Virol 70:5230-5. 1996
    ..More importantly, the treatment of mice with IL-4 resulted in an extremely significant delay in virus clearance. Thus, IL-4 can inhibit both primary and secondary antiviral immune responses...
  101. ncbi In interleukin-4-deficient mice, alum not only generates T helper 1 responses equivalent to freund's complete adjuvant, but continues to induce T helper 2 cytokine production
    J M Brewer
    Department of Immunology, University of Strathclyde, Glasgow, Scotland
    Eur J Immunol 26:2062-6. 1996
    ..However, although production of the Th2 cytokine IL-5 was totally inhibited in IL-4-deficient mice inoculated with FCA/OVA, there was no significant difference in IL-5 production between the two strains when alum was used as adjuvant...

Research Grants42

  1. Heavy Metal-Induced Autoimmunity
    DWIGHT KONO; Fiscal Year: 2005
    ....
  2. PATHOGENESIS OF MURINE SYSTEMIC LUPUS ERYTHEMATOSUS
    DWIGHT KONO; Fiscal Year: 2009
    ..Identification of the susceptibility genes and elucidation of their roles in the induction of lupus should provide significant insights into the etiopathogenesis of genetically-determined autoimmune diseases. ..
  3. Cell Cycle Inhibition in Systemic Autoimmunity
    DWIGHT KONO; Fiscal Year: 2009
    ..These studies should yield important new insights into the significance and role of p21 in systemic autoimmunity and in host response to foreign antigens. ..
  4. Surfactant-Protein Innate Immunity in an Asthma Model
    Angela Haczku; Fiscal Year: 2008
    ..The potential opportunity to interfere with allergic sensitization by SP-D treatment bears high clinical significance. [unreadable] [unreadable]..
  5. IMMUNE ESCAPE MECHANISMS IN LEISHMANASIS
    Imtiaz Khan; Fiscal Year: 2006
    ..These studies have implications for the development of therapies and vaccines directed toward Leishmania infections as well as the mechanisms that regulate Th1/Th2 cytokine development in vivo. ..
  6. Inflammatory Bowel Disease in TCR-Mutant Mice
    Atul Bhan; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable] ..
  7. Regulation of Inflammation by Somatostatin via SSTR 2
    David Elliott; Fiscal Year: 2006
    ..The results of these studies will provide rationale for novel therapeutic treatment of IBD and other inflammatory diseases. ..
  8. Role of T cells in self-limited mucosal infections
    Lynn Bry; Fiscal Year: 2006
    ..This training provides a necessary step in the candidate's goal to become an independent researcher investigating questions in mucosal immunology and host-microbial cross-talk in intestinal environments. ..
  9. Quercetin Treatment of Airway Inflammation
    MARC HERSHENSON; Fiscal Year: 2006
    ..This project examines the value of quercetin, a plant pigment, in preventing airway inflammation in mouse models of disease. This work may lead to new treatments for asthma, cystic fibrosis or chronic bronchitis. ..
  10. Genetic Linkage Analysis of Liver Disease in Mice
    JAMES GORHAM; Fiscal Year: 2006
    ..This will have important implications for understanding the genetic basis of autoimmune hepatitis, and of hepatocellular damage in the settings of HCV infection. ..
  11. Natural Killer Cell Mediated Control of Vaccinia Virus
    Anthony French; Fiscal Year: 2007
    ..The proposed work will occur under the mentorship of Dr. Wayne Yokoyama a recognized pioneer in the NK cell field who has successfully trained numerous graduate students and postdoctoral fellows. [unreadable] [unreadable]..
  12. Role of Galectin-4 in Colitis
    Atsushi Mizoguchi; Fiscal Year: 2008
    ..These studies will not only enhance understanding of the pathogenic mechanisms of IBD but also provide important information to develop new therapeutic approaches for human IBD. ..
  13. Regulation of Inflammation in Asthma by Fas Ligand
    Angela Haczku; Fiscal Year: 2009
    ..Finally, in order to help support the hypothesis that pro-apoptotic FasL activity characterized in human airway cells is truly physiologic, we will perform challenge studies in mice under FasL neutralizing conditions. ..
  14. T CELL CONTROL OF AIRWAY MUCUS PRODUCTION
    Lauren Cohn; Fiscal Year: 2009
    ..AIM II. Determine the mechanism of IFN-g inhibition of eosinophilia and its relationship to the reciprocal induction of neutrophilia. AIM III. Determine how IFN-g regulates the number of Th2 cells in the respiratory tract. ..
  15. Rhinovirus and COPD exacerbations
    MARC HERSHENSON; Fiscal Year: 2009
    ..Understanding viral-induced exacerbations of chronic obstructive pulmonary disease (COPD) will lead to improvements in the treatment of this disease, thereby increasing survival and quality of life for patients. ..
  16. Analyzing and modulating immunoregulatory defects in autoimmune disease.
    Michele M Kosiewicz; Fiscal Year: 2010
    ..abstract_text> ..
  17. Multipotent lung mesenchymal cells in neonatal lung injury
    Marc B Hershenson; Fiscal Year: 2010
    ..Understanding the role of multipotent lung mesenchymal cells in the pathogenesis of BPD will lead to improvements in the treatment of this disease. ..
  18. Crimson - i2b2 integration for high-throughput, scalable sample collection
    Lynn Bry; Fiscal Year: 2010
    ....
  19. Direct IL-4 and IL-13 effects on pulmonary smooth muscle in allergic airway disea
    FRED DOUGLASS FINKELMAN; Fiscal Year: 2010
    ..Proposed studies with a mouse model in which airway hyperresponsiveness is induced solely by direct IL-4 and IL-13 effects on smooth muscle should help to elucidate these mechanisms and may reveal new approaches for asthma therapy. ..
  20. Requirements for regulatory T cell development
    MICHELE KOSIEWICZ; Fiscal Year: 2003
    ..These experiments may determine the requirements for regulatory T cell development, and thereby, identify pathways that can be therapeutically manipulated to prevent and/or treat autoimmune diseases. ..
  21. A novel inbred mouse model of autoimmune hepatitis
    JAMES GORHAM; Fiscal Year: 2002
    ..The proposal seeks to understand mechanisms that regulate the development of inflammation in the liver, so as to gain insights into the pathogenic mechanisms of AIH and other hepatic inflammatory diseases. ..
  22. CAPACITATIVE CALCIUM ENTRY DEFECT IN IMMUNE DEFICIENCY
    Anjana Rao; Fiscal Year: 2002
    ..Deletion mapping using spectral karyotyping and microsatellite markers will be used to further narrow down the chromosomal region involved in the defect and candidate genes in this region will be evaluated. ..
  23. LEISHMANIA INFECTION IN BALB/C IL4 NEG AND IL4R NEG MICE
    Nancy Noben Trauth; Fiscal Year: 2002
    ..major parasites and will offer alternative theories to the Th1/Th2 paradigm in general. These studies also will lead to new interpretations of the action of anti-IL-4 treatment in vivo. ..
  24. IMMUNOMODULATORY STRATEGIES IN AUTOIMMUNE GASTRITIS
    MICHELE KOSIEWICZ; Fiscal Year: 2002
    ..This strategy may be used in conjunction with TGFbeta-treated APCs to successfully treat established autoimmune disease. ..
  25. TH2-MEDIATED INFLAMMATORY RESPONSES IN THE SKIN AND LUNG
    CHRISTINA HERRICK; Fiscal Year: 2002
    ..My goal is to continue basic science investigation of atopic skin disease as a junior faculty member in the Department of Dermatology at Yale School of Medicine. ..
  26. SIGNAL TRANSDUCTION AND AIRWAY SMOOTH MUSCLE HYPERPLASIA
    MARC HERSHENSON; Fiscal Year: 2003
    ..abstract_text> ..
  27. IL4R AND IMMUNITY TO GI NEMATODE PARASITES
    Fred Finkelman; Fiscal Year: 2003
    ....
  28. CYTOKINE REGULATION OF A MOUSE MODEL OF ASTHMA
    Fred Finkelman; Fiscal Year: 2003
    ..By clarifying the mechanisms by which cytokines induce pulmonary inflammation and airway responsiveness, the proposed studies will provide information important for rational therapy for asthma. ..
  29. Mechanisms of liver disease in a mouse model of AIH
    JAMES GORHAM; Fiscal Year: 2006
    ..The final aim is to analyze the genetics, mechanisms, and specificity of hepatic BALB/c-TGF-b1(-/-) effector cytotoxic T lymphocytes. ..
  30. Sex-based differences in regulatory T cell responses
    MICHELE KOSIEWICZ; Fiscal Year: 2004
    ..The results of these studies will provide important information that can lead to the development of novel therapies for the prevention and treatment of autoimmune disease. ..
  31. CMV RETINITIS AND VIRAL RESISTANCE
    DOUGLAS JABS; Fiscal Year: 2003
    ....
  32. RAC 1 SIGNALING PATHWAY IN AIRWAY SMOOTH MUSCLE
    MARC HERSHENSON; Fiscal Year: 2002
    ..These studies may shed light on parallel mechanisms that may operate in asthma, and lead to therapeutic interventions. ..
  33. Role of arginine deficiency in pathogenesis of lupus
    Minoru Satoh; Fiscal Year: 2004
    ..abstract_text> ..
  34. Manipulation of T cell tolerance with small organic mol*
    Anjana Rao; Fiscal Year: 2005
    ..The hope is that the 'information obtained from this pilot R21 proposal will eventually be extended to whole animal models of transplant and tumour rejection, allergy and autoimmune disease. ..
  35. Protective role of cross-reactive anti-enteric antibody
    Lynn Bry; Fiscal Year: 2005
    ....
  36. Analysis of Viral Resistance in CMV Retinitis
    DOUGLAS JABS; Fiscal Year: 2005
    ....
  37. Cellular targets of IL-4 and IL-13 in worm expulsion
    Fred Finkelman; Fiscal Year: 2007
    ..It should also be useful for the intelligent prediction of risks associated with agents that inhibit allergic inflammation. ..
  38. Role of Inflammatory Cytokines in the Allergic Response
    Fred Finkelman; Fiscal Year: 2007
    ..abstract_text> ..
  39. REGULATION OF IL4 PRODUCTION IN VIVO
    Fred Finkelman; Fiscal Year: 2002
    ..The results of these experiments will provide a better understanding of how IL-4 responses are regulated in vivo; this understanding will enhance the ability to control disorders that are regulated by IL-4. ..
  40. Th2 responses in the cutaneous environment
    Christina A Herrick; Fiscal Year: 2010
    ..abstract_text> ..
  41. OCULAR IMMUNOPATHOLOGY IN AUTOIMMUNE MODELS
    DOUGLAS JABS; Fiscal Year: 2001
    ....