Genomes and Genes
Gene Symbol: Il23a
Description: interleukin 23, alpha subunit p19
Alias: IL-23, p19, interleukin-23 subunit alpha, IL-23 subunit alpha, IL-23-A, IL-23p19, interleukin-23 subunit p19
Publications125 found, 100 shown here
- Development of experimental cerebral malaria is independent of IL-23 and IL-17Hidekazu Ishida
Department of Microbiology and Immunology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Biochem Biophys Res Commun 402:790-5. 2010..In conclusion, this study showed that IL-23 and IL-17 are not involved in ECM development...
- IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challengeShabaana A Khader
Trudeau Institute, Saranac Lake, New York 12983, USA
Nat Immunol 8:369-77. 2007....
- Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensisYinyao Lin
Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
Immunity 31:799-810. 2009..Together, these findings illustrate a biological function for IL-17A in regulating IL-12-Th1 cell immunity and host responses to an intracellular pathogen...
- Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironmentMarcin Kortylewski
Department of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute at City of Hope, Duarte, CA 91010, USA
Cancer Cell 15:114-23. 2009..IL-23, which is mainly produced by tumor-associated macrophages, via direct transcriptional activation of the IL-23/p19 gene...
- IL-23, not IL-12, directs autoimmunity to the Goodpasture antigenJoshua D Ooi
Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, 246 Clayton Road, Clayton, VIC 3168, Australia
J Am Soc Nephrol 20:980-9. 2009..In conclusion, autoreactivity to the Goodpasture antigen is directed primarily by IL-23, absence of which results in hyporeactivity including but extending beyond a deficient Th17 response...
- IL-23 promotes the production of IL-17 by antigen-specific CD8 T cells in the absence of IL-12 and type-I interferonsMeredith M Curtis
Department of Immunology, University of Washington School of Medicine, Seattle, 98195, USA
J Immunol 183:381-7. 2009..Thus, CD8 T cells retain sufficient plasticity to respond to environmental cues and can acquire additional effector functions in response to their environmental context...
- IL-23 induces stronger sustained CTL and Th1 immune responses than IL-12 in hepatitis C virus envelope protein 2 DNA immunizationSang Jun Ha
National Research Laboratory of DNA Medicine, Division of Molecular and Life Sciences, Pohang University of Science and Technology, San 31 Hyoja Dong, Nam Gu, Pohang 790 784, Republic of Korea
J Immunol 172:525-31. 2004IL-23 is a heterodimeric cytokine consisting of p19 and the p40 subunit of IL-12. IL-23 has been shown to possess IL-12-like biological activities, but is different in its capacity to stimulate memory T cells in vitro...
- Essential roles of IL-12 and dendritic cells but not IL-23 and macrophages in lupus-like diseases initiated by cell surface HSP gp96Jie Dai
Center for Immunotherapy of Cancer and Infectious Diseases, Department of Immunology, University of Connecticut School of Medicine, Farmington, CT 06030 1601, USA
Eur J Immunol 37:706-15. 2007..was abrogated in transgenic mice expressing membrane-bound gp96 reconstituted with p35-/- BM, but not with p19-/- BM. Moreover, we found that dendritic cells (DC) but not macrophages were the main producers of p40...
- Immune regulation at the interface during early steps of murine implantation: involvement of two new cytokines of the IL-12 family (IL-23 and IL-27) and of TWEAKAnne Elisabeth Mas
Unité 782 INSERM, Hôpital Antoine Béclére AP HP 92141 Clamart, France
Am J Reprod Immunol 59:323-38. 2008..We therefore searched for regulators of the IL-12/IL-18 family of cytokines as well as for antagonist(s) of TNF with potentially selective effects on implantation...
- Notch- and transducin-like enhancer of split (TLE)-dependent histone deacetylation explain interleukin 12 (IL-12) p70 inhibition by zymosanYolanda Alvarez
Instituto de Biologia y Genetica Molecular, Consejo Superior de Investigaciones Cientificas, 47003 Valladolid, Spain
J Biol Chem 286:16583-95. 2011..The transcriptional regulation of il23a, one of the chains of IL-23, depended on the activation of c-Rel and histone H3 phosphorylation, as judged from ..
- Inhibition of ERK MAPK suppresses IL-23- and IL-1-driven IL-17 production and attenuates autoimmune diseaseCorinna F Brereton
Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
J Immunol 183:1715-23. 2009....
- Respiratory virus-induced TLR7 activation controls IL-17-associated increased mucus via IL-23 regulationNicholas W Lukacs
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
J Immunol 185:2231-9. 2010..Thus, without TLR7-mediated responses, an altered immune environment ensued with a significant effect on airway epithelial cell remodeling and goblet cell hyper/metaplasia, leading to increased mucus production...
- IL-23 enhances the inflammatory cell response in Cryptococcus neoformans infection and induces a cytokine pattern distinct from IL-12Melanie A Kleinschek
Institute of Immunology, College of Veterinary Medicine, University of Leipzig, Leipzig, Germany
J Immunol 176:1098-106. 2006IL-23, a heterodimeric cytokine composed of the p40 subunit of IL-12 and a novel p19 subunit, has been shown to be a key player in models of autoimmune chronic inflammation...
- IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in miceJohn S Cho
Division of Dermatology, UCLA, Los Angeles, California 90095, USA
J Clin Invest 120:1762-73. 2010..Our study defines what we believe to be a novel role for IL-17-producing epidermal gammadelta T cells in innate immunity against S. aureus cutaneous infection...
- Cutting edge: IFN-gamma regulates the induction and expansion of IL-17-producing CD4 T cells during mycobacterial infectionAndrea Cruz
Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal
J Immunol 177:1416-20. 2006..This counterregulation pathway may be an important factor in limiting mycobacterially associated immune-mediated pathology...
- Fas ligand induces cell-autonomous IL-23 production in dendritic cells, a mechanism for Fas ligand-induced IL-17 productionHiroyasu Kidoya
Center for the Development of Molecular Target Drugs, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
J Immunol 175:8024-31. 2005..Finally, FasL induced only weak p40 production in a mixture of p40-/- and Fas-/- DC, indicating that FasL induces IL-23 production in DC mainly in a cell-autonomous manner...
- Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitisChristoph Becker
Laboratory of Immunology, First Medical Clinic, University of Mainz, Mainz, Germany
J Immunol 177:2760-4. 2006..IL-12, seems to drive the pathogenesis of experimental autoimmune encephalomyelitis and arthritis, because IL-23/p19 knockout mice are protected from disease...
- Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cellsAstrid J van Beelen
Department of Cell Biology and Histology, Academic Medical Centre of the University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
Immunity 27:660-9. 2007..Thus, antibacterial Th17-mediated immunity in humans is orchestrated by DCs upon sensing bacterial NOD2-ligand MDP...
- Invariant NKT cells produce IL-17 through IL-23-dependent and -independent pathways with potential modulation of Th17 response in collagen-induced arthritisY Yoshiga
Division of Clinical Immunology, Major of Advanced Biomedical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
Int J Mol Med 22:369-74. 2008..Our findings indicate that iNKT cells are producers and activators of IL-17 via IL-23- dependent and -independent pathways, suggesting that they are key cells in the pathogenesis of CIA through IL-17...
- Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestineColby Zaph
Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA
J Exp Med 205:2191-8. 2008..We propose that acquisition of, or alterations in, commensal bacteria influences intestinal immune homeostasis via direct regulation of the IL-25-IL-23-IL-17 axis...
- DC activated via dectin-1 convert Treg into IL-17 producersFabiola Osorio
Immunobiology Laboratory, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, London, UK
Eur J Immunol 38:3274-81. 2008..These results indicate that some Foxp3(+) T cells can produce IL-17 while retaining Foxp3 expression and suggest that Treg could play an unexpected pro-inflammatory role in some settings...
- The role of IL-23/IL-17 axis in lupus nephritisZheng Zhang
Division of Rheumatology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
J Immunol 183:3160-9. 2009..Kidney specimens from these recipient mice show significant Ig and complement deposition. The data indicate that an aberrantly active IL-23/IL-17 axis contributes to the development of nephritis in lupus-prone mice...
- IL-23 receptor regulates unconventional IL-17-producing T cells that control bacterial infectionsLorena Riol-Blanco
Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA, USA
J Immunol 184:1710-20. 2010..Our results show that IL-23 regulates the function of IL-17-producing gammadelta and DN T cells, two essential components of the early protective immune response directed against intracellular pathogens...
- Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12B Oppmann
DNAX Research Institute, Palo Alto, CA 94304, USA
Immunity 13:715-25. 2000..This factor, which we term p19, shows no biological activity by itself; instead, it combines with the p40 subunit of IL-12 to form a novel, ..
- Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature deathM T Wiekowski
Department of Immunology, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
J Immunol 166:7563-70. 2001b>p19, a molecule structurally related to IL-6, G-CSF, and the p35 subunit of IL-12, is a subunit of the recently discovered cytokine IL-23...
- Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is presentAndrea M Cooper
Mycobacteria Research Laboratories, Department of Microbiology, Colorado State University, Fort Collins, CO 80523, USA
J Immunol 168:1322-7. 2002..This cytokine is composed of the IL-12 p40 subunit and a p19 subunit. In support of a role for this cytokine in protective responses to M...
- Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17Sudeepta Aggarwal
Department of Molecular Biology, Genentech, South San Francisco, California 94080, USA
J Biol Chem 278:1910-4. 2003..These data suggest that during a secondary immune response, IL-23 can promote an activation state with features distinct from the well characterized Th1 and Th2 profiles...
- Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brainDaniel J Cua
Department of Immunology, DNAX Research Inc, Palo Alto, California 94304 1104, USA
Nature 421:744-8. 2003..The cytokine IL-23, which comprises the p40 subunit of IL-12 but a different p19 subunit, is produced predominantly by macrophages and dendritic cells, and shows activity on memory T cells...
- Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammationCraig A Murphy
Discovery Research, DNAX Research Inc, Palo Alto, CA 94304, USA
J Exp Med 198:1951-7. 2003Interleukin (IL) 23 is a heterodimeric cytokine composed of a p19 subunit and the p40 subunit of IL-12. IL-23 affects memory T cell and inflammatory macrophage function through engagement of a novel receptor (IL-23R) on these cells...
- Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient miceNico Ghilardi
Department of Molecular Biology, Genentech, South San Francisco, CA 94080, USA
J Immunol 172:2827-33. 2004The heterodimeric cytokine IL-23 consists of a private cytokine-like p19 subunit and a cytokine receptor-like subunit, p40, which is shared with IL-12...
- IL-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12Linda A Lieberman
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
J Immunol 173:1887-93. 2004..Together, these studies indicate that IL-12, not IL-23, plays a dominant role in resistance to toxoplasmosis but, in the absence of IL-12, IL-23 can provide a limited mechanism of resistance to this infection...
- IL-23 drives a pathogenic T cell population that induces autoimmune inflammationClaire L Langrish
Discovery Research, DNAX Research Inc, Palo Alto, CA 94304, USA
J Exp Med 201:233-40. 2005Interleukin (IL)-23 is a heterodimeric cytokine composed of a unique p19 subunit, and a common p40 subunit shared with IL-12...
- Transforming growth factor-beta induces development of the T(H)17 lineagePaul R Mangan
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 2170, USA
Nature 441:231-4. 2006..The action of TGF-beta on naive T cells is antagonized by interferon-gamma and IL-4, thus providing a mechanism for divergence of the T(H)1, T(H)2 and T(H)17 lineages...
- IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6David Yen
Department of Discovery Research, Schering Plough Biopharma, Palo Alto, California 94304, USA
J Clin Invest 116:1310-6. 2006..This pathway may be responsible for chronic intestinal inflammation as well as other chronic autoimmune inflammatory diseases...
- Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitisYi Chen
Discovery Research, Schering Plough Biopharma, Palo Alto, California 94304, USA
J Clin Invest 116:1317-26. 2006..Thus, therapeutic targeting of IL-23 effectively inhibited multiple inflammatory pathways that are critical for driving CNS autoimmune inflammation...
- IL-23 promotes tumour incidence and growthJohn L Langowski
Schering Plough Biopharma, 901 California Avenue, Palo Alto, California 94304, USA
Nature 442:461-5. 2006..We show that IL-23 is an important molecular link between tumour-promoting pro-inflammatory processes and the failure of the adaptive immune surveillance to infiltrate tumours...
- Selective regulatory function of Socs3 in the formation of IL-17-secreting T cellsZhi Chen
Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 103:8137-42. 2006..We conclude that Socs3 is an essential negative regulator of IL-23 signaling, inhibition of which constrains the generation of Th17 differentiation...
- Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infectionShabaana A Khader
Trudeau Institute, Inc, Saranac Lake, NY 12983, USA
J Exp Med 203:1805-15. 2006..These data define a novel and fundamental role for IL-12p40 in the pathogen-induced activation of pulmonary DCs...
- Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptidesSpencer C Liang
Wyeth Research, Cambridge, MA 02140, USA
J Exp Med 203:2271-9. 2006..Collectively, we have identified IL-22 as a new cytokine expressed by Th17 cells that synergizes with IL-17A or IL-17F to regulate genes associated with skin innate immunity...
- IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitisMarika C Kullberg
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 203:2485-94. 2006....
- Interleukin-23 drives innate and T cell-mediated intestinal inflammationSophie Hue
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, England, UK
J Exp Med 203:2473-83. 2006..These results newly identify IL-23 as a driver of innate immune pathology in the intestine and suggest that selective targeting of IL-23 represents an attractive therapeutic approach in human IBD...
- IL-25 regulates Th17 function in autoimmune inflammationMelanie A Kleinschek
Discovery Research, Schering Plough Biopharma, Palo Alto, CA 94304, USA
J Exp Med 204:161-70. 2007..Thus, IL-25 and IL-17, being members of the same cytokine family, play opposing roles in the pathogenesis of organ-specific autoimmunity...
- IL-23 is critical in the induction but not in the effector phase of experimental autoimmune encephalomyelitisParesh Thakker
Department of Inflammation, Wyeth Research, Cambridge, MA 02140, USA
J Immunol 178:2589-98. 2007..wild-type (WT) mice caused indistinguishable disease when adoptively transferred to WT or IL-23-deficient (p19 knockout (KO)) recipient mice, demonstrating that once encephalitogenic cells have been generated, EAE can develop ..
- The proinflammatory effect of prostaglandin E2 in experimental inflammatory bowel disease is mediated through the IL-23-->IL-17 axisAmir F Sheibanie
Department of Physiology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, PA 19140, USA
J Immunol 178:8138-47. 2007..These studies suggest that high levels of PGE(2) exacerbate the inflammatory process through the preferential expression and release of DC-derived IL-23 and the subsequent support of the autoreactive/inflammatory Th17 phenotype...
- IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistanceTeresa Zelante
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
Eur J Immunol 37:2695-706. 2007..As IL-23-driven inflammation promotes infection and impairs antifungal resistance, modulation of the inflammatory response represents a potential strategy to stimulate protective immune responses to fungi...
- A proximal kappaB site in the IL-23 p19 promoter is responsible for RelA- and c-Rel-dependent transcriptionSetsuko Mise-Omata
Technology and Development Team for BioSignal Program, Subteam for BioSignal Integration, RIKEN BioResource Center, RIKEN Tsukuba Institute, Tsukuba, Japan
J Immunol 179:6596-603. 2007IL-23 is a heterodimeric cytokine composed of a unique p19 subunit and a common p40 subunit is shared with IL-12. IL-23 promotes the inflammatory response by inducing the expansion of CD4(+) cells producing IL-17...
- Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogensYan Zheng
Department of Immunology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA
Nat Med 14:282-9. 2008..rodentium infection. Together, our data identify a new innate immune function for IL-22 in regulating early defense mechanisms against A/E bacterial pathogens...
- Salivary gland tissue expression of interleukin-23 and interleukin-17 in Sjögren's syndrome: findings in humans and miceCuong Q Nguyen
Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA
Arthritis Rheum 58:734-43. 2008..Importantly, Th17 cells appear to be intimately involved in autoimmunity. We undertook the present study to investigate whether the Th17/IL-23 system is up-regulated in Sjögren's syndrome (SS)...
- Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector categoryDror Luger
Laboratory of Immunology, National Eye Institute NEI, National Institutes of Health NIH, Bethesda, MD 20892, USA
J Exp Med 205:799-810. 2008..These data also raise the possibility that the nonredundant requirement for IL-23 in EAU may extend beyond its role in promoting the Th17 effector response and help provide a balance in the current Th1 versus Th17 paradigm...
- Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitisAna Izcue
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
Immunity 28:559-70. 2008..Taken together, our data indicate that overriding immunosuppressive pathways is an important function of IL-23 in the intestine and could influence not only Th17 cell activity but also other types of immune responses...
- IL-23 and Th17 cells enhance Th2-cell-mediated eosinophilic airway inflammation in miceHidefumi Wakashin
Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan
Am J Respir Crit Care Med 178:1023-32. 2008..However, the role of the IL-23-Th17 cell axis in the regulation of allergic airway inflammation is still largely unknown...
- Interleukin-23 orchestrates mucosal responses to Salmonella enterica serotype Typhimurium in the intestineIvan Godinez
Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Ave, Davis, CA 95616 8645, USA
Infect Immun 77:387-98. 2009..Collectively, our results point to IL-23 as an important player in initiating a T-cell-dependent amplification of inflammatory responses in the intestinal mucosa during serotype Typhimurium infection...
- A human natural killer cell subset provides an innate source of IL-22 for mucosal immunityMarina Cella
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Nature 457:722-5. 2009....
- Protective immunity to systemic infection with attenuated Salmonella enterica serovar enteritidis in the absence of IL-12 is associated with IL-23-dependent IL-22, but not IL-17Silke M Schulz
Institute of Immunology, College of Veterinary Medicine, University of Leipzig, Leipzig, Germany
J Immunol 181:7891-901. 2008..To characterize the role of the related cytokine IL-23, wild-type (WT) C57BL/6 and p19(-/-) mice were infected systemically with an attenuated strain of Salmonella enterica serovar Enteritidis (S...
- Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasisHeather R Conti
Department of Oral Biology, School of Dental Medicine, State University of New York, Buffalo, NY 14201, USA
J Exp Med 206:299-311. 2009..Thus, the Th17 lineage, acting largely through IL-17, confers the dominant response to oral candidiasis through neutrophils and antimicrobial factors...
- Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma productionHenrique P Lemos
Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, São Paulo 14 049 900, Brazil
Proc Natl Acad Sci U S A 106:5954-9. 2009..We thus provide a mechanism for the pathogenic role of the IL-23/IL-17 axis in RA and also suggest an additional mechanism of action for nonsteroidal anti-inflammatory drugs...
- Cutting edge: IL-23 receptor gfp reporter mice reveal distinct populations of IL-17-producing cellsAmit Awasthi
Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
J Immunol 182:5904-8. 2009....
- Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injuryTakashi Shichita
Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan
Nat Med 15:946-50. 2009..We propose that T lymphocytes, including gammadeltaT lymphocytes, could be a therapeutic target for mitigating the inflammatory events that amplify the initial damage in cerebral ischemia...
- Natural occurring IL-17 producing T cells regulate the initial phase of neutrophil mediated airway responsesShinya Tanaka
Laboratory for Signal Network, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Tsurumi, Yokohama, Kanagawa, Japan
J Immunol 183:7523-30. 2009..10 Rag(-/-) mice. These results demonstrate that a novel T cell subset, nTh17, facilitates the early phase of Ag-induced airway responses and host defenses against pathogen invasion before the establishment of acquired immunity...
- IL-23 is required for protection against systemic infection with Listeria monocytogenesKaren D Meeks
Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
J Immunol 183:8026-34. 2009..These results indicate that during LM infection, IL-23 regulates the production of IL-17A and IL-17F from gammadelta T cells, resulting in optimal liver neutrophil recruitment and enhanced bacterial clearance...
- Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17Melba Munoz
Institute of Microbiology and Hygiene, Campus Benjamin Franklin, Charite Medical School, 12203 Berlin, Germany
J Exp Med 206:3047-59. 2009..Thus, IL-23 regulates small intestinal inflammation via IL-22 but independent of IL-17. Gelatinases may be useful targets for treatment of intestinal inflammation...
- Interleukin-23 is critical for full-blown expression of a non-autoimmune destructive arthritis and regulates interleukin-17A and RORgammat in gammadelta T cellsFerry Cornelissen
Department of Rheumatology, Erasmus Medical Center Rotterdam, Dr, Molewaterplein 50, Rotterdam, 3015 GE, The Netherlands
Arthritis Res Ther 11:R194. 2009..In addition, the regulatory potential of IL-23 in IL-17A and retinoic acid-related orphan receptor gamma t (RORgammat) expression in CD4+ and TCRgammadelta+ T cells was evaluated systemically as well as at the site of inflammation...
- Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathologySofia Buonocore
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
Nature 464:1371-5. 2010..These results identify a previously unrecognized IL-23-responsive innate lymphoid population that mediates intestinal immune pathology and may therefore represent a target in inflammatory bowel disease...
- IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasisMichele W L Teng
Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
Proc Natl Acad Sci U S A 107:8328-33. 2010..Overall, these data indicate the general role that IL-23 plays in suppressing natural or cytokine-induced innate immunity, promoting tumor development and metastases independently of IL-17A...
- IL-17A-producing gammadelta T and Th17 lymphocytes mediate lung inflammation but not fibrosis in experimental silicosisSandra Lo Re
Louvain Centre for Toxicology and applied Pharmacology, de Duve Institute, Universite Catholique de Louvain, Brussels, Belgium
J Immunol 184:6367-77. 2010..Although the acute alveolitis induced by silica is IL-17A dependent, this cytokine appears dispensable for the development of the late inflammatory and fibrotic lung responses to silica...
- A novel immunoregulatory function for IL-23: Inhibition of IL-12-dependent IFN-γ productionAmy N Sieve
Department of Molecular Biology and Immunology, The University of North Texas Health Science Center, Fort Worth, TX 76107, USA
Eur J Immunol 40:2236-47. 2010..Our data suggest that IL-23 may be a key factor in determining the responsiveness of lymphocytes to IL-12 and their subsequent secretion of IFN-γ...
- Interleukin-23 drives intestinal inflammation through direct activity on T cellsPhilip P Ahern
Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, England, UK
Immunity 33:279-88. 2010..Together, these results highlight the multiple functions of IL-23 signaling in T cells that contribute to its colitogenic activity...
- IL-23 and IL-17A, but not IL-12 and IL-22, are required for optimal skin host defense against Candida albicansShinji Kagami
Department of Dermatology, Oregon Health and Science University, Portland, OR 97239, USA
J Immunol 185:5453-62. 2010..In addition, recombinant IL-17A may serve as a potential therapy to enhance healing in individuals with chronic cutaneous candidiasis...
- IL-23-mediated psoriasis-like epidermal hyperplasia is dependent on IL-17AHeather L Rizzo
Department of Dermatology, Oregon Health and Science University, Portland, OR 97239, USA
J Immunol 186:1495-502. 2011..IL-17A may represent an attractive therapeutic target in individuals with psoriasis by blocking downstream effects of IL-23...
- CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gutGregory F Sonnenberg
Department of Microbiology and Institute for Immunology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Immunity 34:122-34. 2011..Collectively these data demonstrate that adult CD4(+) LTi cells are a critical source of IL-22 and identify a previously unrecognized function for CD4(+) LTi cells in promoting innate immunity in the intestine...
- Fate mapping of IL-17-producing T cells in inflammatory responsesKeiji Hirota
Division of Molecular Immunology, Medical Research Council National Institute for Medical Research, Mill Hill, London, UK
Nat Immunol 12:255-63. 2011..Thus, this model allows the actual functional fate of effector T cells to be related to T(H)17 developmental origin regardless of IL-17 expression...
- The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSFMohamed El-Behi
Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
Nat Immunol 12:568-75. 2011..Such cross-regulation of IL-23 and GM-CSF explains the similar pattern of resistance to autoimmunity when either of the two cytokines is absent and identifies T(H)17 cells as a crucial source of GM-CSF in autoimmune inflammation...
- IL-23 is critical for induction of arthritis, osteoclast formation, and maintenance of bone massIannis E Adamopoulos
Discovery Research, Merck Research Laboratories, Palo Alto, CA 94304, USA
J Immunol 187:951-9. 2011....
- IL-23 is required for long-term control of Mycobacterium tuberculosis and B cell follicle formation in the infected lungShabaana A Khader
Division of Infectious Diseases, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA
J Immunol 187:5402-7. 2011..However, mice deficient for the p19 component of IL-23 (Il23a(-/-)) exhibit increased bacterial growth late in infection that is temporally associated with smaller B cell ..
- Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defenseMelissa A Kinnebrew
Infectious Diseases Service, Department of Medicine, Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Immunity 36:276-87. 2012..Thus, CD103(+)CD11b(+) LPDCs, in addition to promoting long-term tolerance to ingested antigens, also rapidly produce IL-23 in response to detection of flagellin in the lamina propria...
- IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cellsJonathan P Sherlock
Merck Research Laboratories, Palo Alto, California, USA
Nat Med 18:1069-76. 2012....
- Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteriaRajatava Basu
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Immunity 37:1061-75. 2012..These findings establish Th22 cells as an important component of mucosal antimicrobial host defense...
- Autoimmune memory T helper 17 cell function and expansion are dependent on interleukin-23Christopher J Haines
Merck Research Laboratories, 901 California Avenue, Palo Alto, CA 94304, USA
Cell Rep 3:1378-88. 2013....
- Interleukin-17-induced protein lipocalin 2 is dispensable for immunity to oral candidiasisMaria Carolina Ferreira
Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Infect Immun 82:1030-5. 2014..Moreover, Lcn2 deficiency mediated protection from OPC induced by steroid immunosuppression. Therefore, despite its potent regulation during C. albicans infection, Lcn2 is not required for immunity to mucosal candidiasis...
- The adaptor CARD9 is required for adaptive but not innate immunity to oral mucosal Candida albicans infectionsShrinivas Bishu
Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Infect Immun 82:1173-80. 2014..Thus, CARD9 is important primarily for adaptive immunity to C. albicans, whereas alternate recognition systems appear to be needed for effective innate responses. ..
- IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is availableShabaana A Khader
Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA
J Immunol 175:788-95. 2005..IL-23 is an IL-12p40-dependent cytokine containing an IL-12p40 subunit covalently bound to a p19 subunit that is implicated in the induction of CD4 T cells associated with autoimmunity and inflammation...
- Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniaeKyle I Happel
Section of Pulmonary and Critical Care Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
J Exp Med 202:761-9. 2005Interleukin (IL)-23 is a heterodimeric cytokine that shares the identical p40 subunit as IL-12 but exhibits a unique p19 subunit similar to IL-12 p35...
- Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathologyHolm H Uhlig
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE Oxford, UK
Immunity 25:309-18. 2006..colitis, but not wasting disease or serum proinflammatory cytokine production, depended on interleukin-23 p19 secretion, whereas interleukin-12 p35 secretion controlled wasting disease and serum cytokine production but not ..
- Functional relevance of the IL-23-IL-17 axis in lungs in vivoStefan Ivanov
Lung Pharmacology and Immunology Groups, Department of Internal Medicine Respiratory Medicine and Allergology, Institute of Medicine, Sahlgrenska Academy at Goteborg University, Guldhedsgatan 10A, S 413 46 Gothenburg, Sweden
Am J Respir Cell Mol Biol 36:442-51. 2007..These findings support that IL-23 and IL-17 form a functionally relevant "immunological axis" in the lungs in vivo...
- Interleukin-23 (IL-23)-IL-17 cytokine axis in murine Pneumocystis carinii infectionXiaowen L Rudner
Section of Pulmonary and Critical Care Medicine, Department of Medicine, Louisiana State University, LSU Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112, USA
Infect Immun 75:3055-61. 2007..In IL-23p19-/- mice infected with P. carinii, there were fewer effector CD4(+) T cells in the lung tissue. Collectively, these studies indicate that the IL-23-IL-17 axis participates in host defense against P. carinii...
- In vitro differentiation of dendritic cells in the presence of prostaglandin E2 alters the IL-12/IL-23 balance and promotes differentiation of Th17 cellsTanzilya Khayrullina
Department of Microbiology and Immunology, School of Medicine, Temple University, Philadelphia, PA 19140, USA
J Immunol 181:721-35. 2008..high IL-23 production in LPS-stimulated DCp is associated with the down-regulation of p35 and the up-regulation of p19 expression, respectively...
- Interleukin-23 promotes Th17 differentiation by inhibiting T-bet and FoxP3 and is required for elevation of interleukin-22, but not interleukin-21, in autoimmune experimental arthritisAdriana M C Mus
Erasmus MC, University Medical Center, 3015 CE Rotterdam, The Netherlands
Arthritis Rheum 62:1043-50. 2010..To examine the role of interleukin-23 (IL-23) in subgroup polarization of IL-17A-positive and/or interferon-gamma (IFNgamma)-positive T cells in autoimmune disease-prone DBA/1 mice with and without collagen-induced arthritis...
- Interleukin-23 restores immunity to Mycobacterium tuberculosis infection in IL-12p40-deficient mice and is not required for the development of IL-17-secreting T cell responsesTeresa M Wozniak
Mycobacterial Research Group, Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia
J Immunol 177:8684-92. 2006..Therefore, exogenous IL-23 can complement IL-12 deficiency for the initial expansion of Ag-specific T cells and is not essential for the development of potentially protective IL-17-secreting T cells...
- IL-23 is required for the development of severe egg-induced immunopathology in schistosomiasis and for lesional expression of IL-17Laura I Rutitzky
Department of Pathology, School of Medicine, Tufts University, 150 Harrison Avenue, Boston, MA 02111, USA
J Immunol 180:2486-95. 2008..We now show that mice lacking the IL-23-specific subunit p19 are impaired in developing severe immunopathology following immunization with SEA/CFA, which is associated with a ..
- Toll-like receptor 2 signaling in CD4(+) T lymphocytes promotes T helper 17 responses and regulates the pathogenesis of autoimmune diseaseJoseph M Reynolds
Department of Immunology and Center for Inflammation and Cancer, M D Anderson Cancer Center, Houston, TX 77054, USA
Immunity 32:692-702. 2010..This study thus reveals a critical role of a TLR in the direct regulation of adaptive immune response and pathogenesis of autoimmune diseases...
- TLR2 deficiency by compromising p19 (IL-23) expression limits Th 17 cell responses to Mycobacterium tuberculosisMaria Teixeira-Coelho
Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus de Gualtar, 4710 057 Braga, Portugal
Int Immunol 23:89-96. 2011..We show that signaling via Toll-like receptor (TLR) 2 has a major impact on the regulation of p19 (IL-23) expression in response to M. tuberculosis and therefore on the establishment of T(h)17 cell responses to M...
- Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growthSergei I Grivennikov
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, California 92093 0723, USA
Nature 491:254-8. 2012..We propose that barrier deterioration induced by colorectal-cancer-initiating genetic lesions results in adenoma invasion by microbial products that trigger tumour-elicited inflammation, which in turn drives tumour growth...
- MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signalingJiHoon Chang
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 110:2270-5. 2013..Taken together, our results demonstrate that MyD88 has a dual function in Th17 cells by delivering IL-1 signaling during the early differentiation stage and integrating IL-23 signaling to the mTOR complex to expand committed Th17 cells...
- Tumor-secreted lactic acid promotes IL-23/IL-17 proinflammatory pathwayHiroaki Shime
Department of Molecular Genetics, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
J Immunol 180:7175-83. 2008IL-23 is a proinflammatory cytokine consisting of a p19 subunit and a p40 subunit that is shared with IL-12. IL-23 is overexpressed in and around tumor tissues, where it induces local inflammation and promotes tumor development...
- AP-1 activated by toll-like receptors regulates expression of IL-23 p19Weicheng Liu
Immunology Institute, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
J Biol Chem 284:24006-16. 2009..We demonstrate that induction of IL-23 p19 gene expression by LPS depends on the TLR4 and MyD88 pathways...
- CD8+ cells enhance resistance to pulmonary serotype 3 Streptococcus pneumoniae infection in miceSarah E Weber
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Immunol 186:432-42. 2011....
- Analysis of cytokine regulators inducing interferon production by mouse uterine natural killer cellsJ H Zhang
Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada
Biol Reprod 69:404-11. 2003..The four genes were induced by gd6, and uNK cells isolated from midgestation transcribed IL-23alpha and IL-27R. This study advances the understanding of uNK cell activation during normal pregnancy...
- Antitumor and antimetastatic activity of IL-23Chia Hui Lo
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
J Immunol 171:600-7. 2003..The results showed that CD8(+) T cells, but not CD4(+) T cells or NK cells, were crucial for the antitumor activity of IL-23...
- Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresisDavid Engblom
Division of Cell Biology, Faculty of Health Sciences, University of Linkoping, S 581 85 Linkoping, Sweden
Nat Neurosci 6:1137-8. 2003..Our findings identify mPGES-1 as the central switch during immune-induced pyresis and as a target for the treatment of fever and other PGE2-dependent acute phase reactions elicited by the brain...
- Differential expression and regulation of IL-23 and IL-12 subunits and receptors in adult mouse microgliaJifen Li
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
J Neurol Sci 215:95-103. 2003..Thus, IL-23 produced by CNS microglia/macrophages may contribute to the early induction of EAE. In the CNS, IL-23 may preferentially target infiltrating mononuclear cells, which upregulate IL-23R, rather than parenchymal microglia...
- IL-23 mediates inflammatory responses to mucoid Pseudomonas aeruginosa lung infection in micePatricia J Dubin
Division of Pediatric Pulmonology, Children s Hospital of Pittsburgh, Pittsburgh, PA 15213, USA
Am J Physiol Lung Cell Mol Physiol 292:L519-28. 2007..aeruginosa infection and suggests that IL-23 could be a potential target for immunotherapy to treat airway inflammation in CF...
- IMMUNOPATHOGENESIS OF MYCOBACTERIUM AVIUM DISEASEAndrea Cooper; Fiscal Year: 2001..Finally, they will test the hypothesis that appropriate chemotherapy can restore the correct immunologic functions/signals, using both established regimens, as well as new compounds recently identified in their laboratory as active. ..
- PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUMGEORGE DEEPE; Fiscal Year: 2007..abstract_text> ..
- Impact of chronic infection in the aged on the response to vaccinationAndrea Cooper; Fiscal Year: 2007..These experiments are relevant to human health since determining the effect of inflammation on the response to vaccination will allow us to improve vaccination in the elderly. [unreadable] [unreadable] [unreadable] [unreadable]..
- Defending Against Systemic MycosesGEORGE DEEPE; Fiscal Year: 2008..The collaborative and synergistic effort manifested by this group of investigators will provide new and exciting information regarding prevention and/or treatment of these problematic fungi. ..
- The role of IL-12p40 in the response of pulmonary dendritic cells to tuberculosisAndrea M Cooper; Fiscal Year: 2010..This increased understanding will allow targeted and novel interventions that will improve our ability to control disease. ..