Il1r1

Summary

Gene Symbol: Il1r1
Description: interleukin 1 receptor, type I
Alias: CD121a, CD121b, IL-1R1, IL-iR, Il1r-1, interleukin-1 receptor type 1, CD121 antigen-like family member A, IL-1 receptor alpha chain, IL-1R-1, IL-1R-alpha, IL-1RT-1, IL-1RT1, interleukin-1 receptor alpha, p80
Species: mouse

Top Publications

  1. pmc Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome
    Xianbao He
    Section of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 184:5743-54. 2010
  2. pmc Tumor formation initiated by nondividing epidermal cells via an inflammatory infiltrate
    Esther N Arwert
    Cancer Research UK Cambridge Research Institute, Cambridge CB2 0RE, United Kingdom
    Proc Natl Acad Sci U S A 107:19903-8. 2010
  3. pmc Interleukin-1 participates in the progression from liver injury to fibrosis
    Roben G Gieling
    Department of Surgery, The Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
    Am J Physiol Gastrointest Liver Physiol 296:G1324-31. 2009
  4. doi Type I interferon inhibits interleukin-1 production and inflammasome activation
    Greta Guarda
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Immunity 34:213-23. 2011
  5. ncbi Role of interleukin-1 in the pulmonary immune response during Pseudomonas aeruginosa pneumonia
    Marc J Schultz
    Department of Experimental Internal Medicine, Tropical Medicine, and AIDS, Academic Medical Center of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 282:L285-90. 2002
  6. ncbi IL-1 receptor-mediated signal is an essential component of MyD88-dependent innate response to Mycobacterium tuberculosis infection
    Cecile M Fremond
    University of Orleans, Centre National de la Recherche Scientifique, Molecular Immunology and Embryology, Orleans, France
    J Immunol 179:1178-89. 2007
  7. ncbi Mass spectrometric analysis of the endogenous type I interleukin-1 (IL-1) receptor signaling complex formed after IL-1 binding identifies IL-1RAcP, MyD88, and IRAK-4 as the stable components
    Constantinos Brikos
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, London, UK
    Mol Cell Proteomics 6:1551-9. 2007
  8. pmc Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment
    Mahtab Moayeri
    Laboratory of Bacterial Diseases, Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 6:e1001222. 2010
  9. ncbi Neuroinflammation and both cytotoxic and vasogenic edema are reduced in interleukin-1 type 1 receptor-deficient mice conferring neuroprotection
    Jelena Lazovic
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA, USA
    Stroke 36:2226-31. 2005
  10. ncbi Regulation of interleukin-1 receptors and hypothalamic-pituitary-adrenal axis by lipopolysaccharide treatment in the mouse
    T Takao
    Second Department of Internal Medicine, Kochi Medical School, Nankoku, Japan
    Brain Res 649:265-70. 1994

Research Grants

  1. 2008 Biology of Acute Respiratory Infections Gordon Research Conference
    JOSEPH MIZGERD; Fiscal Year: 2007
  2. Investigation of Nod2: Implications for Uveitis
    Holly Rosenzweig; Fiscal Year: 2008
  3. CANINE AS AN ANIMAL MODEL OF HUMAN AGING
    Carl Cotman; Fiscal Year: 2005
  4. B1B lymphocytes generate T cell-independent memory
    KISHORE ALUGUPALLI; Fiscal Year: 2009
  5. Role of CNS CD4+ T cells in TMEV-induced Demyelination
    Byung Kim; Fiscal Year: 2008
  6. Brain Aging & Gene Expression Patterns Using Microarrays
    Carl Cotman; Fiscal Year: 2007
  7. ABeta Immunization in Aging
    Carl Cotman; Fiscal Year: 2005
  8. ACTIVITY DEPENDENT PLASTICITY IN THE AGING BRAIN
    Carl Cotman; Fiscal Year: 2004
  9. APOPTOTIC INSULTS SUPPRESS MARKERS NEURONAL PLASTICITY
    Carl Cotman; Fiscal Year: 2004
  10. RSV AND ASTHMA
    David Broide; Fiscal Year: 2003

Detail Information

Publications169 found, 100 shown here

  1. pmc Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome
    Xianbao He
    Section of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 184:5743-54. 2010
    ..pneumoniae directly activates the NLRP3/ASC inflammasome, leading to the release of biologically active IL-1beta, and that concurrent IL-1 signaling is required for optimal host defense against acute bacterial pneumonia...
  2. pmc Tumor formation initiated by nondividing epidermal cells via an inflammatory infiltrate
    Esther N Arwert
    Cancer Research UK Cambridge Research Institute, Cambridge CB2 0RE, United Kingdom
    Proc Natl Acad Sci U S A 107:19903-8. 2010
    ..In contrast, our studies show that differentiated epidermal cells can initiate tumor formation without reacquiring the ability to divide and that they do so by triggering an inflammatory infiltrate...
  3. pmc Interleukin-1 participates in the progression from liver injury to fibrosis
    Roben G Gieling
    Department of Surgery, The Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
    Am J Physiol Gastrointest Liver Physiol 296:G1324-31. 2009
    ..Thus IL-1 is an important participant, along with other cytokines, and controls the progression from liver injury to fibrogenesis through activation of HSCs in vivo...
  4. doi Type I interferon inhibits interleukin-1 production and inflammasome activation
    Greta Guarda
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Immunity 34:213-23. 2011
    ..Our findings may thus explain the effectiveness of type I IFN in the treatment of inflammatory diseases but also the observed "weakening" of the immune system after viral infection...
  5. ncbi Role of interleukin-1 in the pulmonary immune response during Pseudomonas aeruginosa pneumonia
    Marc J Schultz
    Department of Experimental Internal Medicine, Tropical Medicine, and AIDS, Academic Medical Center of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 282:L285-90. 2002
    ..05). These results demonstrate that an absence or reduction in endogenous IL-1 activity improves host defense against Pseudomonas pneumonia while suppressing the inflammatory response...
  6. ncbi IL-1 receptor-mediated signal is an essential component of MyD88-dependent innate response to Mycobacterium tuberculosis infection
    Cecile M Fremond
    University of Orleans, Centre National de la Recherche Scientifique, Molecular Immunology and Embryology, Orleans, France
    J Immunol 179:1178-89. 2007
    ....
  7. ncbi Mass spectrometric analysis of the endogenous type I interleukin-1 (IL-1) receptor signaling complex formed after IL-1 binding identifies IL-1RAcP, MyD88, and IRAK-4 as the stable components
    Constantinos Brikos
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, London, UK
    Mol Cell Proteomics 6:1551-9. 2007
    ..The only component of the IL-1RI signaling complex that dissociated is IRAK-1. Our study is therefore the first detailed description of the endogenous IL-1RI complex...
  8. pmc Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment
    Mahtab Moayeri
    Laboratory of Bacterial Diseases, Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Pathog 6:e1001222. 2010
    ..These data confirm an inverse relationship between murine macrophage sensitivity to lethal toxin and mouse susceptibility to spore infection, and establish roles for Nlrp1b(S), caspase-1, and IL-1β in countering anthrax infection...
  9. ncbi Neuroinflammation and both cytotoxic and vasogenic edema are reduced in interleukin-1 type 1 receptor-deficient mice conferring neuroprotection
    Jelena Lazovic
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA, USA
    Stroke 36:2226-31. 2005
    ....
  10. ncbi Regulation of interleukin-1 receptors and hypothalamic-pituitary-adrenal axis by lipopolysaccharide treatment in the mouse
    T Takao
    Second Department of Internal Medicine, Kochi Medical School, Nankoku, Japan
    Brain Res 649:265-70. 1994
    ..abstract truncated at 250 words)..
  11. ncbi Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling
    Jurgen Radons
    Klinik und Poliklinik für Innere Medizin I, Universitat Regensburg, D 93042 Regensburg, Germany
    J Biol Chem 277:16456-63. 2002
    ..Taken together, our data indicate that box 3 of IL-1RAcP is critical for IL-1-dependent NF-kappaB activation and stabilization of IL-2 mRNA via JNK, whereas aa 527-534 largely contribute to IL-2 promoter activation...
  12. pmc IL-1 beta signalling in glial cells in wildtype and IL-1RI deficient mice
    Lisa C Parker
    School of Biological Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, U K
    Br J Pharmacol 136:312-20. 2002
    ..5. These data demonstrate that IL-1RI is essential for IL-1beta signalling in cultured mixed glial cells. Thus IL-1 actions observed in IL-1RI-/- mice in vivo may occur via an alternative pathway and/or via different CNS cells...
  13. pmc Specific role of interleukin-1 in hepatic neutrophil recruitment after ischemia/reperfusion
    Atsushi Kato
    Department of Surgery, University of Cincinnati College of Medicine, Ohio 45267, USA
    Am J Pathol 161:1797-803. 2002
    ..These data suggest that IL-1 functions to augment neutrophil accumulation, but does not play an essential role in this response...
  14. ncbi Nuclear factor kappaB nuclear translocation as a crucial marker of brain response to interleukin-1. A study in rat and interleukin-1 type I deficient mouse
    Agnes Nadjar
    INRA INSERM U 394, Institut F Magendie, Bordeaux, France
    J Neurochem 87:1024-36. 2003
    ..The study of the consequences of the impairment of NFkappaB pathway activation in in vivo experimentation should bring important clues about the precise role of this transcription factor...
  15. pmc Leukocyte-derived interleukin-1beta interacts with renal interleukin-1 receptor I to promote renal tumor necrosis factor and glomerular injury in murine crescentic glomerulonephritis
    Jennifer R Timoshanko
    Department of Medicine, Centre for Inflammatory Diseases, Monash Medical Centre, Monash University, Clayton, Victoria, Australia
    Am J Pathol 164:1967-77. 2004
    ..These studies demonstrate that leukocytes are the major cellular source of IL-1beta, and that IL-1beta acts principally via the IL-1RI on intrinsic renal cells to induce TNF expression and crescentic glomerular injury...
  16. ncbi System x(c)- activity and astrocytes are necessary for interleukin-1 beta-mediated hypoxic neuronal injury
    Birgit Fogal
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Neurosci 27:10094-105. 2007
    ....
  17. pmc Sleep-wake behavior and responses to sleep deprivation of mice lacking both interleukin-1 beta receptor 1 and tumor necrosis factor-alpha receptor 1
    Francesca Baracchi
    Department of Anesthesiology, University of Michigan, 7422 Medical Sciences Building I, 1150 W Medical Center Drive, Ann Arbor, MI 48109 5615, USA
    Brain Behav Immun 22:982-93. 2008
    ..These results provide additional evidence that the IL-1 beta and TNFalpha cytokine systems play a role in sleep regulation and in the alterations in sleep that follow prolonged wakefulness...
  18. pmc Interleukin-1-mediated hematopoietic cell regulation in the aorta-gonad-mesonephros region of the mouse embryo
    Claudia Orelio
    Department of Cell Biology and Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Blood 112:4895-904. 2008
    ..Our results suggest that IL-1 is an important homeostatic regulator at the earliest time of HSC development, acting to limit the differentiation of some HSCs along the myeloid lineage...
  19. pmc Localized inflammation in peripheral tissue signals the CNS for sickness response in the absence of interleukin-1 and cyclooxygenase-2 in the blood and brain
    H Zhang
    Institute of Behavior Medicine, 3132 Postle Hall, 305 West 12th Avenue, Ohio State University, Columbus, OH 43210 1094, USA
    Neuroscience 157:895-907. 2008
    ..These findings suggest that local inflammation can activate the CNS via pathways distinguishable from those mediating systemic inflammation-induced CNS activation...
  20. doi Environmental enrichment restores memory functioning in mice with impaired IL-1 signaling via reinstatement of long-term potentiation and spine size enlargement
    Inbal Goshen
    Department of Psychology, The Hebrew University, Jerusalem 91905, Israel
    J Neurosci 29:3395-403. 2009
    ....
  21. pmc Disruption of interleukin-1 signaling improves the quality of wound healing
    Alan A Thomay
    Division of Surgical Research, Rhode Island Hospital, NAB 216, 593 Eddy St, Providence, RI 02903, USA
    Am J Pathol 174:2129-36. 2009
    ..These findings suggest that pharmacological interference with IL-1 signaling could have therapeutic value in the prevention of hypertrophic scarring and in the treatment of fibrotic diseases...
  22. doi Astrocytes initiate inflammation in the injured mouse spinal cord by promoting the entry of neutrophils and inflammatory monocytes in an IL-1 receptor/MyD88-dependent fashion
    Isabelle Pineau
    Department of Molecular Medicine, Laval University, Quebec, Quebec, Canada G1V 4G2
    Brain Behav Immun 24:540-53. 2010
    ..Together, these results indicate that MyD88/IL-1R1 signals regulate the entry of neutrophils and, to a lesser extent, type I "inflammatory" monocytes at sites of SCI...
  23. doi High-fat diet stimulates IL-1 type I receptor-mediated inflammatory signaling in the skeletal muscle of mice
    Seung Jin Kim
    Department of Food and Nutrition, Brain Korea 21 Project, Yonsei University, Seoul 120 749, Korea
    Mol Nutr Food Res 54:1014-20. 2010
    ..These results suggest that the IL-1RI-MyD88-nuclear factor kappaB signaling pathway might be involved in the induction of the inflammatory response in the skeletal muscle of mice fed with an HFD...
  24. pmc Distinct roles for Dectin-1 and TLR4 in the pathogenesis of Aspergillus fumigatus keratitis
    Sixto M Leal
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS Pathog 6:e1000976. 2010
    ....
  25. pmc Mice lacking both TNF and IL-1 receptors exhibit reduced lung inflammation and delay in onset of death following infection with a highly virulent H5N1 virus
    Lucy A Perrone
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Infect Dis 202:1161-70. 2010
    ..In particular, H5N1 virus infections are associated with a high expression of the proinflammatory cytokines, including interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-α)...
  26. pmc IL-1β-mediated signals preferentially drive conversion of regulatory T cells but not conventional T cells into IL-17-producing cells
    Lequn Li
    Department of Hematology Oncology and Cancer Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA 02215, USA
    J Immunol 185:4148-53. 2010
    ..These observations could have important implications on therapeutic strategies using Tregs...
  27. ncbi Role of interleukin (IL)-1 type 1 receptor in mycobacterial infection
    I Sugawara
    Department of Molecular Pathology, The Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, Kiyose, Tokyo
    Microbiol Immunol 45:743-50. 2001
    ..Interferon-y production by spleen cells was low in IL-1 R1 KO mice. It is concluded that the IL-1 R1 is essential for IL-1-mediated signaling events in mycobacterial infection...
  28. ncbi The IL-1 receptor 1 is critical for Th2 cell type airway immune responses in a mild but not in a more severe asthma model
    Nicole Schmitz
    Molecular Biomedicine, Swiss Federal Institute of Technology Zurich, Zurich, Switzerland
    Eur J Immunol 33:991-1000. 2003
    ..These results suggest a critical role of IL-1/IL-1R1 for development of allergic Th2 responses, but its requirement can be overcome by using alum as adjuvant for sensitization...
  29. pmc Interleukin-1beta and signaling of interleukin-1 in vascular wall and circulating cells modulates the extent of neointima formation in mice
    Janet Chamberlain
    Cardiovascular Research Unit, University of Sheffield, Clinical Sciences Centre, Northern General Hospital, Herries Road, Sheffield, S5 7AU, UK
    Am J Pathol 168:1396-403. 2006
    ..Furthermore, receptor antagonism may be a better therapeutic target than interruption of IL-1beta processing or release...
  30. ncbi The type I interleukin-1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF-transgenic mice
    L Probert
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Eur J Immunol 25:1794-7. 1995
    ..Our results show that in TNF-transgenic mice the IL-1 receptor accepts the whole pathogenic load of TNF, thereby acting as a potent downstream mediator in the pathogenesis of chronic arthritis...
  31. ncbi The type II 'decoy' receptor: a novel regulatory pathway for interleukin 1
    F Colotta
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Immunol Today 15:562-6. 1994
    ..Here, Francesco Colotta and colleagues review the properties of these receptors and summarize evidence indicating that the type II receptor acts as a regulated decoy target for IL-1...
  32. ncbi Expression of type I and type II interleukin-1 receptors in mouse brain
    P Parnet
    INRA INSERM, Laboratory of Integrative Neurobiology, Bordeaux, France
    Brain Res Mol Brain Res 27:63-70. 1994
    ..These data show that mouse brain expresses both type I and type II IL-1 receptor mRNA and proteins and offer further support to the idea that type I IL-1 receptors are synthesized and expressed by neurons...
  33. pmc Inflammatory and hyperproliferative skin disease in mice that express elevated levels of the IL-1 receptor (type I) on epidermal keratinocytes. Evidence that IL-1-inducible secondary cytokines produced by keratinocytes in vivo can cause skin disease
    R W Groves
    Harvard Skin Disease Research Center, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Invest 98:336-44. 1996
    ....
  34. ncbi Mice lacking the type I interleukin-1 receptor do not lose bone mass after ovariectomy
    J A Lorenzo
    VA Connecticut Healthcare System, Newington 06111, USA
    Endocrinology 139:3022-5. 1998
    ..Hence, therapeutic interventions that block the effects of IL-1 on bone may be beneficial for treating diseases of rapid bone loss such as post-menopausal osteoporosis...
  35. ncbi IL-1 and TNF independent pathways mediate ICAM-1/VCAM-1 up-regulation in ischemia reperfusion injury
    M J Burne
    Nephrology Division, Hennepin County Medical Center, University of Minnesota, Minneapolis 55415, USA
    J Leukoc Biol 70:192-8. 2001
    ..Neutrophil migration in KO mice was decreased at 24 h but comparable to WT at 48 h. These data demonstrate that IL-1 and TNF are not essential for postischemic increases in ICAM-1 and VCAM-1...
  36. ncbi Interleukin-1 influences ischemic brain damage in the mouse independently of the interleukin-1 type I receptor
    Omar Touzani
    School of Biological Sciences, University of Manchester, M13 9PT, United Kingdom
    J Neurosci 22:38-43. 2002
    ..These data show that IL-1beta can exacerbate ischemic brain damage independently of IL-1RI and suggest the existence of additional signaling receptor or receptors for IL-1 in the brain...
  37. ncbi The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling
    Elizabeth Lye
    Advanced Medical Discovery Institute, University Health Network, Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2C1, Canada
    J Biol Chem 279:40653-8. 2004
    ..These results suggest that IRAK-4 is an integral part of the IL-1R signaling cascade and is capable of transmitting signals both dependent on and independent of its kinase activity...
  38. pmc Central IL-1 receptor signaling regulates bone growth and mass
    Alon Bajayo
    Bone Laboratory, Hebrew University of Jerusalem, Jerusalem 91120, Israel
    Proc Natl Acad Sci U S A 102:12956-61. 2005
    ....
  39. ncbi Genetic impairment of interleukin-1 signaling attenuates neuropathic pain, autotomy, and spontaneous ectopic neuronal activity, following nerve injury in mice
    Gilly Wolf
    Department of Psychology, Hebrew University, Mount Scopus, Jerusalem 91905, Israel
    Pain 120:315-24. 2006
    ..Taken together, these results suggest that IL-1 signaling plays an important role in neuropathic pain and in the altered neuronal activity that underlies its development...
  40. ncbi Distinct roles for IL-1 receptor type I signaling in early versus established Leishmania major infections
    Susanna Lopez Kostka
    Department of Dermatology, Johannes Gutenberg University Mainz, Mainz, Germany
    J Invest Dermatol 126:1582-9. 2006
    ..Effects of IL-1 on disease outcome may be related to levels of IL-1RI on Th subpopulations...
  41. pmc MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals
    Chun Jen Chen
    Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Clin Invest 116:2262-71. 2006
    ..These results indicate that IL-1 is essential for the MSU-induced inflammatory response and that the requirement of MyD88 in this process is primarily through its function as an adaptor molecule in the IL-1R signaling pathway...
  42. doi Cardioprotective function of the long pentraxin PTX3 in acute myocardial infarction
    Monica Salio
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Circulation 117:1055-64. 2008
    ..It was therefore important to assess whether PTX3 plays a pathogenetic role in acute myocardial infarction...
  43. pmc Interleukin-1 receptor type I signaling critically regulates infarct healing and cardiac remodeling
    Marcin Bujak
    Section of Cardiovascular Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Pathol 173:57-67. 2008
    ..Thus, interventional therapeutics targeting the IL-1 system may have great benefits in myocardial infarction...
  44. pmc Interleukin-1 regulates multiple atherogenic mechanisms in response to fat feeding
    Janet Chamberlain
    Cardiovascular Research Unit, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield, United Kingdom
    PLoS ONE 4:e5073. 2009
    ..We hypothesised that interleukin-1 (IL-1) signaling in the vessel wall would raise arterial blood pressure and promote atheroma...
  45. pmc Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo
    Nelson C Di Paolo
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Immunity 31:110-21. 2009
    ..Thus, these data identify IL-1 alpha-IL-1RI as a key pathway allowing for the activation of proinflammatory responses to the virus, independently of its genomic nucleic acid recognition...
  46. doi Myeloid differentiation factor-88/interleukin-1 signaling controls cardiac fibrosis and heart failure progression in inflammatory dilated cardiomyopathy
    Przemyslaw Blyszczuk
    Department of Cardiology, University Hospital, Zurich, Switzerland
    Circ Res 105:912-20. 2009
    ....
  47. doi IL-1-induced inflammation promotes development of leishmaniasis in susceptible BALB/c mice
    Elena Voronov
    Shraga Segal Department of Microbiology and Immunology, The Cancer Research Center, Faculty of Health Sciences and Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Int Immunol 22:245-57. 2010
    ..Thus, manipulation of IL-1 levels in the host, using the IL-1Ra or specific antibodies, has the potential to alleviate symptoms of visceral manifestations of leishmaniasis...
  48. ncbi In situ histochemical localization of type I interleukin-1 receptor messenger RNA in the central nervous system, pituitary, and adrenal gland of the mouse
    E T Cunningham
    Neurobiology Laboratory, National Institute on Drug Abuse, Addiction Research Center, Baltimore, Maryland 21224
    J Neurosci 12:1101-14. 1992
    ..It also supports studies suggesting that IL-1-mediated activation of the hypothalamic-pituitary-adrenal axis occurs primarily at the level of the brain and/or pituitary gland...
  49. ncbi Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex
    S A Greenfeder
    Department of Inflammation Autoimmune Diseases, Roche Research Center, Hoffmann La Roche Inc, Nutley, New Jersey 07110, USA
    J Biol Chem 270:13757-65. 1995
    ..Therefore, the functional IL-1 receptor appears to be a complex composed of at least two subunits...
  50. pmc Demonstration of the presence of an interleukin-1 receptor on the surface of murine astrocytes and its regulation by cytokines and Theiler's virus
    N Rubio
    Department of Neuroimmunology, Instituto Cajal, Madrid, Spain
    Immunology 82:178-83. 1994
    ..The receptor expression was up-regulated by Theiler's virus, interferon-gamma, tumour necrosis factor and IL-6; was not affected by vaccinia virus infection; and decreased after lipopolysaccharide treatment...
  51. ncbi Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice
    M Labow
    Hoffmann La Roche, Nutley, NJ 07110, USA
    J Immunol 159:2452-61. 1997
    ..These data also demonstrate that IL-1 function is not required for normal development or homeostasis...
  52. ncbi Phenotypic and functional characterization of mice that lack the type I receptor for IL-1
    M B Glaccum
    Immunex Corporation, Seattle, WA 98101, USA
    J Immunol 159:3364-71. 1997
    ..Interestingly, ICE-/-/type I IL-1R-/- double mutant mice are resistant to high dose LPS. Type I IL-1R-/- mice backcrossed to the C57BL/6 background were as equally resistant as wild-type mice to Listeria monocytogenes...
  53. ncbi TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation
    J J Peschon
    Department of Molecular Immunology, Immunex Corp, Seattle, WA 98101, USA
    J Immunol 160:943-52. 1998
    ..In summary, these data help clarify the biologic roles of p55 and p75 in mediating and modulating the biologic activity of TNF and provide genetic evidence for an antagonistic role of p75 in vivo...
  54. ncbi Role of IL-1 in renal ischemic reperfusion injury
    M Haq
    Department of Internal Medicine, University of South Florida, Tampa, USA
    J Am Soc Nephrol 9:614-9. 1998
    ..05) h. Recovery in the IL-1Ra group was similar to that in the control animals. These data demonstrate that IL-1 is unlikely to be beneficial in the recovery of renal function after ischemia and may play a deleterious role...
  55. ncbi Enhanced Th2-like responses in IL-1 type 1 receptor-deficient mice
    A R Satoskar
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston 02115, USA
    Eur J Immunol 28:2066-74. 1998
    ....
  56. ncbi Unresponsiveness of MyD88-deficient mice to endotoxin
    T Kawai
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
    Immunity 11:115-22. 1999
    ....
  57. ncbi Severity of elastase-induced emphysema is decreased in tumor necrosis factor-alpha and interleukin-1beta receptor-deficient mice
    Edgar C Lucey
    The Pulmonary Center, Boston University School of Medicine, 80 East Concord Street, Boston, Massachusetts 02118, USA
    Lab Invest 82:79-85. 2002
    ....
  58. ncbi Critical role of signaling through IL-1 receptor for development of arthritis and sepsis during Staphylococcus aureus infection
    Olof H Hultgren
    Department of Rheumatology, Goteborg University, Guldhedsgatan 10A, S 413 46 Goteborg, Sweden
    J Immunol 168:5207-12. 2002
    ..In conclusion, IL-1R signaling plays a crucial role in host protection during systemic S. aureus infection as seen by the fatal outcome of S. aureus sepsis and arthritis in IL-1R-deficient mice...
  59. pmc IL-1 plays an important role in lipid metabolism by regulating insulin levels under physiological conditions
    Taizo Matsuki
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Exp Med 198:877-88. 2003
    ..These observations suggest that IL-1 plays an important role in lipid metabolism by regulating insulin levels and lipase activity under physiological conditions...
  60. ncbi Impaired interleukin-1 signaling is associated with deficits in hippocampal memory processes and neural plasticity
    Avi Avital
    Department of Psychology, Haifa University, Haifa, Israel
    Hippocampus 13:826-34. 2003
    ....
  61. ncbi IL-1 receptor deficiency slows progression to diabetes in the NOD mouse
    Helen E Thomas
    St Vincent s Institute of Medical Research, Fitzroy, Vic, Australia
    Diabetes 53:113-21. 2004
    ..3 TCR transgenic NOD mice but prolonged the time to diabetes in BDC2.5 TCR transgenic NOD mice. We conclude that IL-1R deficiency slows progression to diabetes in NOD mice but on its own does not prevent diabetes...
  62. ncbi The contribution of the Toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo
    Silvia Bellocchio
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    J Immunol 172:3059-69. 2004
    ..albicans and A. fumigatus require the coordinated action of distinct members of the IL-1R/TLR superfamily acting through MyD88 makes TLR manipulation amenable to the induction of host resistance to fungi...
  63. pmc IL-1 mediates TNF-induced osteoclastogenesis
    Shi Wei
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 115:282-90. 2005
    ..Thus, IL-1 mediates the osteoclastogenic effect of TNF by enhancing stromal cell expression of RANKL and directly stimulating differentiation of osteoclast precursors...
  64. pmc Interleukin-1 is responsible for acute lung immunopathology but increases survival of respiratory influenza virus infection
    Nicole Schmitz
    Molecular Biomedicine, ETH Zurich, Wagistrasse 27, 8952 Zurich, Switzerland
    J Virol 79:6441-8. 2005
    ..IL-1alpha/beta appear not to influence killing of virus-infected cells but to enhance IgM antibody responses and recruitment of CD4(+) T cells to the site of infection...
  65. ncbi Gout-associated uric acid crystals activate the NALP3 inflammasome
    Fabio Martinon
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Nature 440:237-41. 2006
    ..These findings provide insight into the molecular processes underlying the inflammatory conditions of gout and pseudogout, and further support a pivotal role of the inflammasome in several autoinflammatory diseases...
  66. ncbi MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus
    Lloyd S Miller
    Division of Dermatology, David Geffen School of Medicine at UCLA, 52 121 CHS, 10833 Le Conte Avenue, Los Angeles, California 90095, USA
    Immunity 24:79-91. 2006
    ..This neutrophil recruitment was not dependent upon IL-1R/MyD88 signaling by recruited bone marrow-derived cells, suggesting that resident skin cells utilize IL-1R/MyD88 signaling to promote neutrophil recruitment...
  67. ncbi Abnormal T cell activation caused by the imbalance of the IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitis
    Taizo Matsuki
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Int Immunol 18:399-407. 2006
    ..These observations suggest that the IL-1/IL-1Ra system is crucial for auto-antigen-specific T cell induction and contributes to the development of EAE...
  68. ncbi IL-1beta, but not IL-1alpha, is required for antigen-specific T cell activation and the induction of local inflammation in the delayed-type hypersensitivity responses
    Aya Nambu
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Shirokanedai, Tokyo 108 8639, Japan
    Int Immunol 18:701-12. 2006
    ..In addition, CD4+ T cell-derived IL-1 plays an important role in the activation of DCs during the elicitation phase, resulting in the production of TNF, that activate allergen-specific T cells...
  69. ncbi Perforin and Fas induced by IFNgamma and TNFalpha mediate beta cell death by OT-I CTL
    Mark D McKenzie
    St Vincent s Institute, Fitzroy, Melbourne, Australia
    Int Immunol 18:837-46. 2006
    ..However, in the absence of perforin, the Fas/FasL pathway provides an alternative mechanism dependent on islet cell Fas upregulation by cytokines IFNgamma and TNFalpha...
  70. ncbi Mature-onset obesity in interleukin-1 receptor I knockout mice
    Maria C Garcia
    Department of Physiology and Wallenberg Laboratory, Goteborg University, Medicinargatan 9A, Goteborg, Sweden
    Diabetes 55:1205-13. 2006
    ..In conclusion, lack of IL-1RI-mediated biological activity causes mature-onset obesity. This obese phenotype is preceded by decreased leptin sensitivity, fat utilization, and locomotor activity...
  71. pmc A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis
    Caroline Sutton
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    J Exp Med 203:1685-91. 2006
    ..Tumor necrosis factor alpha also synergized with IL-23 to enhance IL-17 production, and this was IL-1 dependent. Our findings demonstrate that IL-1 functions upstream of IL-17 to promote pathogenic ThIL-17 cells in EAE...
  72. pmc Role of host cytokine responses in the pathogenesis of avian H5N1 influenza viruses in mice
    Kristy J Szretter
    Influenza Branch MS G 16, Division of Viral and Ricksettial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    J Virol 81:2736-44. 2007
    ..These results suggest that TNF-alpha may contribute to morbidity during H5N1 influenza virus infection, while IL-1 may be important for effective virus clearance in nonlethal H5N1 disease...
  73. ncbi Identification of a key pathway required for the sterile inflammatory response triggered by dying cells
    Chun Jen Chen
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Room S2 109, Worcester, Massachusetts 01655, USA
    Nat Med 13:851-6. 2007
    ....
  74. pmc Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation
    Hal Blumberg
    Department of Inflammation, 2Department of Pathology, 3Department of Biostatistics, Amgen, Seattle, WA 98119, USA
    J Exp Med 204:2603-14. 2007
    ..In summary, dysregulated expression of novel agonistic and antagonistic IL-1 family member ligands can promote cutaneous inflammation, revealing potential novel targets for the treatment of inflammatory skin disorders...
  75. ncbi A dual role for interleukin-1 in hippocampal-dependent memory processes
    Inbal Goshen
    Department of Psychology, The Hebrew University, Jerusalem 91905, Israel
    Psychoneuroendocrinology 32:1106-15. 2007
    ..e., a slight increase in brain IL-1 levels can improve memory, whereas any deviation from the physiological range, either by excess elevation in IL-1 levels or by blockade of IL-1 signaling, results in impaired memory...
  76. pmc IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice
    Pamela Gasse
    Laboratory of Molecular Immunology and Embryology, University of Orleans and CNRS, Orleans, France
    J Clin Invest 117:3786-99. 2007
    ..In conclusion, bleomycin-induced lung pathology required the inflammasome and IL-1R1/MyD88 signaling, and IL-1 represented a critical effector of pathology and therapeutic target of chronic lung inflammation and fibrosis...
  77. pmc IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress
    Ja Wook Koo
    Department of Psychology, Yale University, New Haven, CT 06520 8205, USA
    Proc Natl Acad Sci U S A 105:751-6. 2008
    ..These findings demonstrate that IL-1beta is a critical mediator of the antineurogenic and depressive-like behavior caused by acute and chronic stress...
  78. ncbi Cigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent
    Emilie Doz
    University of Orleans and Centre National de la Recherche Scientifique UMR6218, Molecular Immunology and Embryology, France
    J Immunol 180:1169-78. 2008
    ....
  79. pmc Costimulatory effects of IL-1 on the expansion/differentiation of CD4+CD25+Foxp3+ and CD4+CD25+Foxp3- T cells
    Carine Brinster
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD 20892, USA
    J Leukoc Biol 84:480-7. 2008
    ..These findings have important implications for the design of protocols for the expansion of CD4+CD25+ T cells for cellular biotherapy...
  80. doi The role of interleukin-1beta in murine cigarette smoke-induced emphysema and small airway remodeling
    Andrew Churg
    Department of Pathology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T2B5, Canada
    Am J Respir Cell Mol Biol 40:482-90. 2009
    ....
  81. doi Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis
    Pamela Gasse
    University of Orleans and CNRS, Orleans, France
    Am J Respir Crit Care Med 179:903-13. 2009
    ..The molecular mechanisms by which lung injury triggers IL-1beta production, inflammation, and fibrosis remain poorly understood...
  82. pmc Interleukin-1 regulates hematopoietic progenitor and stem cells in the midgestation mouse fetal liver
    Claudia Orelio
    Erasmus University Medical Centre, Dept of Cell Biology and Genetics, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Haematologica 94:462-9. 2009
    ..Therefore, we set out to investigate whether interleukin-1 also plays a role in regulating fetal liver progenitor cells and hematopoietic stem cells...
  83. doi IL-1-dependent, IL-1R1-independent resistance to gastrointestinal nematodes
    Neil E Humphreys
    Faculty of Life Sciences, The University of Manchester, Manchester, UK
    Eur J Immunol 39:1036-45. 2009
    ....
  84. pmc Critical regulation of early Th17 cell differentiation by interleukin-1 signaling
    Yeonseok Chung
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 30:576-87. 2009
    ..Our data thus indicate a critical role of IL-1 in Th17 cell differentiation and this pathway may serve as a unique target for Th17 cell-mediated immunopathology...
  85. pmc Interleukin-1 receptor null mutant mice show decreased anxiety-like behavior and enhanced fear memory
    Ja Wook Koo
    Department of Neuroscience, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, United States
    Neurosci Lett 456:39-43. 2009
    ..Taken together, the results indicate that the IL-1beta/IL-1RI signaling pathway induces anxiety-related behaviors and impairs fear memory...
  86. pmc Malarial hemozoin is a Nalp3 inflammasome activating danger signal
    Catherine Dostert
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    PLoS ONE 4:e6510. 2009
    ..Thus, we hypothesized that hemozoin could activate the Nalp3 inflammasome, due to its particulate nature reminiscent of other inflammasome-activating agents...
  87. pmc Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo
    Katrin D Mayer-Barber
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:3326-30. 2010
    ..Together our findings reveal a major role for IL-1beta in host resistance to M. tuberculosis and indicate that during this infection the cytokine can be generated by a mechanism that does not require TLR signaling or caspase-1...
  88. pmc Identification of the cellular sensor that stimulates the inflammatory response to sterile cell death
    Hajime Kono
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 184:4470-8. 2010
    ..One key way they accomplish this important task is by producing IL-1alpha that is needed to initiate the inflammatory response...
  89. pmc IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice
    John S Cho
    Division of Dermatology, UCLA, Los Angeles, California 90095, USA
    J Clin Invest 120:1762-73. 2010
    ..Our study defines what we believe to be a novel role for IL-17-producing epidermal gammadelta T cells in innate immunity against S. aureus cutaneous infection...
  90. pmc Interleukin-1 as a phenotypic immunomodulator in keratinizing squamous metaplasia of the ocular surface in Sjögren's syndrome
    Ying Ting Chen
    University of California, San Francisco, Francis I Proctor Foundation, San Francisco, CA 94143, USA
    Am J Pathol 177:1333-43. 2010
    ..These data demonstrate a phenotypic modulation role for IL-1 in the pathogenesis of squamous metaplasia and suggest that IL-1 receptor 1-targeted therapies may be beneficial for treating ocular surface disease associated with SS...
  91. pmc Endothelial IL-1R1 is a critical mediator of EAE pathogenesis
    Qiming Li
    Institute of Behavior Medicine, 3132 Postle Hall, 305 West 12th Avenue, Ohio State University, Columbus, OH 43210 1094, USA
    Brain Behav Immun 25:160-7. 2011
    ..These findings indicate a critical role for endothelial IL-1R1 in mediating the pathogenesis of EAE, and describe a new model that can be used to study endothelial IL-1R1...
  92. pmc Interleukin-1 receptor signaling is required to overcome the effects of pertussis toxin and for efficient infection- or vaccination-induced immunity against Bordetella pertussis
    Xuqing Zhang
    Department of Veterinary and Biomedical Sciences, Pennsylvania State University, 115 Henning Building, University Park, PA 16802, USA
    Infect Immun 79:527-41. 2011
    ..IL-10 treatment reduced B. pertussis numbers in IL-1R(-/-) mice, suggesting that the lower IL-10 responses partially account for the uncontrolled inflammation and bacterial growth in these mice...
  93. pmc Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
    Edward A Miao
    Institute for Systems Biology, Seattle, Washington, USA
    Nat Immunol 11:1136-42. 2010
    ..This demonstrates that activation of caspase-1 clears intracellular bacteria in vivo independently of IL-1β and IL-18 and establishes pyroptosis as an efficient mechanism of bacterial clearance by the innate immune system...
  94. pmc Regulated expression of nuclear receptor RORγt confers distinct functional fates to NK cell receptor-expressing RORγt(+) innate lymphocytes
    Cedric Vonarbourg
    IMMH, Institute of Medical Microbiology and Hygiene, University of Freiburg, 79104 Freiburg, Germany
    Immunity 33:736-51. 2010
    ..Our data also define a previously unappreciated role of RORγt⁻ NKR-LTi cells for the onset or maintenance of inflammatory bowel diseases...
  95. pmc Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
    J Clin Invest 121:554-68. 2011
    ..These data suggest that human vaccines against systemic fungal infections should be designed to induce Th17 cells if they are to be effective...
  96. doi Microenvironment-derived IL-1 and IL-17 interact in the control of lung metastasis
    Yaron Carmi
    Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences and National Institute of Biotechnology, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Immunol 186:3462-71. 2011
    ..Also, we suggest that intervention in IL-1/IL-17 production could be therapeutically used to tilt this balance toward enhanced antitumor immunity...
  97. doi An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma
    Mirjam Kool
    Laboratory of Immunoregulation and Mucosal Immunology, Department of Respiratory Diseases, University Ghent, Ghent 9000, Belgium
    Immunity 34:527-40. 2011
    ..These findings provide further molecular insight into Th2 cell development and identify UA as an essential initiator and amplifier of allergic inflammation...
  98. pmc Lack of interleukin-1 receptor I (IL-1RI) protects mice from high-fat diet-induced adipose tissue inflammation coincident with improved glucose homeostasis
    Fiona C McGillicuddy
    Nutrigenomics Research Group, University College Dublin Conway Institute, School of Public Health and Population Science, University College Dublin, Dublin, Ireland
    Diabetes 60:1688-98. 2011
    ..We hypothesized that lack of IL-1RI may ameliorate HFD-induced IR by attenuating adipose tissue inflammation...
  99. pmc NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis
    Eran Elinav
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 145:745-57. 2011
    ..Altogether, perturbations in this inflammasome pathway, including NLRP6, ASC, caspase-1, and IL-18, may constitute a predisposing or initiating event in some cases of human IBD...
  100. pmc Priming microenvironments dictate cytokine requirements for T helper 17 cell lineage commitment
    Wei Hu
    Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Immunity 35:1010-22. 2011
    ..These results reveal fundamental differences by which the systemic, mucosal, and cutaneous immune systems guide Th17 cell lineage commitment...
  101. pmc IL-1α/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice
    Fernando M Botelho
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, Canada
    PLoS ONE 6:e28457. 2011
    ..Despite this, the cellular and molecular mechanisms that contribute to COPD pathogenesis are still poorly understood...

Research Grants22

  1. 2008 Biology of Acute Respiratory Infections Gordon Research Conference
    JOSEPH MIZGERD; Fiscal Year: 2007
    ..End of Abstract) [unreadable] [unreadable] [unreadable]..
  2. Investigation of Nod2: Implications for Uveitis
    Holly Rosenzweig; Fiscal Year: 2008
    ..Together, these studies will provide valuable new information on how Nod2 is involved in autoimmunity and the pathogeneis of uveitis. ..
  3. CANINE AS AN ANIMAL MODEL OF HUMAN AGING
    Carl Cotman; Fiscal Year: 2005
    ..Overall, this project should provide unique insight into the role of oxidative damage and subsequent molecular cascades on the progression of brain aging and cognitive decline. ..
  4. B1B lymphocytes generate T cell-independent memory
    KISHORE ALUGUPALLI; Fiscal Year: 2009
    ..Understanding the basis for the longevity of the Tl protective responses conferred by B1b cells will provide novel approaches to generate effective vaccines against pathogens expressing Tl antigens. ..
  5. Role of CNS CD4+ T cells in TMEV-induced Demyelination
    Byung Kim; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  6. Brain Aging & Gene Expression Patterns Using Microarrays
    Carl Cotman; Fiscal Year: 2007
    ..Once an initial primary paper is published the overall data will be made available to the field via NACC for various investigators to analyze for the testing their own hypotheses. ..
  7. ABeta Immunization in Aging
    Carl Cotman; Fiscal Year: 2005
    ..Overall, this project should provide unique insight into the efficacy of immunization with fibrillar Abeta and have direct implications for the design of human clinical trials. ..
  8. ACTIVITY DEPENDENT PLASTICITY IN THE AGING BRAIN
    Carl Cotman; Fiscal Year: 2004
    ..Data from the proposed experiments will provide an initial characterization of how a simple, widely practiced activity-exercise-regulates expression of BDNF, a molecule increasingly recognized for its critical role in brain function. ..
  9. APOPTOTIC INSULTS SUPPRESS MARKERS NEURONAL PLASTICITY
    Carl Cotman; Fiscal Year: 2004
    ..Together, these experiments may provide support for a mechanism (s) accounting for some of the well-known changes in brain aging and AD, including reduced activity dependent plasticity, synaptic integrity and neuronal survival. ..
  10. RSV AND ASTHMA
    David Broide; Fiscal Year: 2003
    ..Overall these studies will contribute to our understanding of the mechanism of eosinophilic inflammation during RSV infection and suggest candidate vaccine strategies to inhibit RSV infection and airway inflammation. ..
  11. MECHANISMS OF PATHOLOGICAL NEURITIC & SOMAL DEGENERATION
    Carl Cotman; Fiscal Year: 2002
    ..The studies proposed in this application will provide new and basic biological findings potentially relevant to a wide array of normal and pathological events involving synaptic remodeling and neurite degeneration. ..
  12. Pathogenic Mechanisms of TMEV-induced Demyelination
    Byung Kim; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  13. "The 1st International Conference on Osteoimmunology: Interactions of the Immune
    Joseph Lorenzo; Fiscal Year: 2006
    ..The conference will be held on May 26, 2006 to June 2, 2006 in Crete, Greece. [unreadable] [unreadable] [unreadable] [unreadable]..
  14. Biomarkers in sputum in COPD
    David Broide; Fiscal Year: 2005
    ..abstract_text> ..
  15. Eosinophil Trafficking
    David Broide; Fiscal Year: 2005
    ..Overall, these studies should improve our understanding of the molecular mechanism of eosinophil recruitment in vivo and its effect on airway structure and function. ..
  16. ENDOTHELIUM--SIGNALING FROM MAST CELLS TO EOSINOPHILS
    David Broide; Fiscal Year: 2002
    ....
  17. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
    ..abstract_text> ..
  18. Role of CIC-3 channels in regulation of cell volume and shape in neutrophils
    Jessica Moreland; Fiscal Year: 2007
    ..The studies proposed will advance our fundamental knowledge of the function of neutrophils in the maintenance of normal immune system function. [unreadable] [unreadable] [unreadable]..
  19. NEUTROPHIL RECRUITMENT IN LPS-INDUCED AIRWAY DISEASE
    Jessica Moreland; Fiscal Year: 2004
    ....
  20. Defending Against Systemic Mycoses
    GEORGE DEEPE; Fiscal Year: 2008
    ..The collaborative and synergistic effort manifested by this group of investigators will provide new and exciting information regarding prevention and/or treatment of these problematic fungi. ..
  21. The 2nd International Conference on Osteoimmunology
    Joseph Lorenzo; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..