Il1f5

Summary

Gene Symbol: Il1f5
Description: interleukin 1 family, member 5 (delta)
Alias: AI413231, Fil1delta, IL-36Ra, IL36RN, Il-1h3, Il1hy1, interleukin-36 receptor antagonist protein, IL-1 delta, IL-1F5, IL-1HY1, IL-1L1, interleukin 1 receptor antagonist homolog 1, interleukin-1 HY1, interleukin-1 delta, interleukin-1 family member 5, interleukin-1 homolog 3, interleukin-1-like protein 1
Species: mouse

Top Publications

  1. ncbi Four new members expand the interleukin-1 superfamily
    D E Smith
    Immunex Corp, Seattle, Washington 98101, USA
    J Biol Chem 275:1169-75. 2000
  2. ncbi Identification and initial characterization of four novel members of the interleukin-1 family
    S Kumar
    Department of Bone and Cartilage Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Biol Chem 275:10308-14. 2000
  3. ncbi IL1HY1: A novel interleukin-1 receptor antagonist gene
    J J Mulero
    Functional Genomics Department, Immunology Group, Hyseq Inc, 670 Almanor Avenue, Sunnyvale, California 94086, USA
    Biochem Biophys Res Commun 263:702-6. 1999
  4. ncbi Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2
    R Debets
    DNAX Research Institute of Molecular and Cellular Biology, 901 California Avenue, Palo Alto, CA 94304, USA
    J Immunol 167:1440-6. 2001
  5. ncbi Genomic organization of the interleukin-1 locus
    Scott L Taylor
    Immunex Corporation, 51 University Street, Seattle, Washington 98101, USA
    Genomics 79:726-33. 2002
  6. pmc IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin
    Alexander M Foster
    Department of Dermatology, University of Michigan, Ann Arbor, MI 48109 and
    J Immunol 192:6053-61. 2014
  7. pmc IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression
    Andrew Johnston
    Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 186:2613-22. 2011
  8. pmc Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation
    Hal Blumberg
    Department of Inflammation, 2Department of Pathology, 3Department of Biostatistics, Amgen, Seattle, WA 98119, USA
    J Exp Med 204:2603-14. 2007
  9. ncbi High-resolution structure of murine interleukin 1 homologue IL-1F5 reveals unique loop conformations for receptor binding specificity
    Eleanor F Dunn
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Biochemistry 42:10938-44. 2003
  10. ncbi A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities
    J L Barton
    Division of Molecular and Genetic Medicine, University of Sheffield, Sheffield, GB
    Eur J Immunol 30:3299-308. 2000

Scientific Experts

  • Jennifer E Towne
  • S Kumar
  • Hal Blumberg
  • Gyohei Egawa
  • Solenne Vigne
  • Andrew Johnston
  • John E Sims
  • Alexander M Foster
  • Nicole L Ward
  • Johann E Gudjonsson
  • Andrew M Guzman
  • Luigi Tortola
  • Gaby Palmer
  • Cem Gabay
  • Celine Lamacchia
  • Francesca Ronchi
  • Praxedis Martin
  • Federica Sallusto
  • Emiliana Rodriguez
  • Ceire Costelloe
  • Thomas Westerling
  • Luke A J O'Neill
  • Eleanor F Dunn
  • Cynthia S Chen
  • Jaymie Baliwag
  • Scott L Taylor
  • Stefan W Stoll
  • Brian Abel
  • Anthony J Coyle
  • Matthias Schafer
  • Sabine Werner
  • Manfred Kopf
  • R Debets
  • Irene Garcia
  • Esther Rosenwald
  • Jan Kisielow
  • Dominique Vesin
  • Jean Christoph Renauld
  • Deborah Strebel
  • Maria L Olleros
  • Christian Wohn
  • Candace M Loyd
  • Dominique Talabot-Ayer
  • Lisa E Maier
  • Frank Wang
  • Sewon Kang
  • Xianying Xing
  • Huyen Dinh
  • James T Elder
  • Errol P Prens
  • Marybeth Riblett
  • John J Voorhees
  • J L Barton
  • D E Smith
  • Aine Murphy
  • Melanie Watson
  • Christine Loscher
  • Cecilia Garlanda
  • Marina A Lynch
  • Kingston H G Mills
  • J J Mulero
  • Keith McQuillan
  • Alberto Mantovani
  • Michelle E Armstrong
  • Emilia Kuuluvainen
  • Tomi P Makela
  • David P Gearing
  • Nicholas J Gay
  • Xue Yuan Pei
  • Adrian F Bristow
  • Kirsten E Garka
  • Blair R Renshaw
  • Dirk E Smith
  • J C Timans
  • J Wagner
  • S Menon
  • T R Sana
  • S Zurawski
  • T Clifford
  • S Lo
  • J F Bazan
  • R A Kastelein
  • B Homey
  • G Edwards
  • M J Nicklin
  • R R Ketchem
  • J E Sims
  • L Higgins
  • K E Garka
  • R Herbst

Detail Information

Publications17

  1. ncbi Four new members expand the interleukin-1 superfamily
    D E Smith
    Immunex Corp, Seattle, Washington 98101, USA
    J Biol Chem 275:1169-75. 2000
    We report here the cloning and characterization of four new members of the interleukin-1 (IL-1) family (FIL1delta, FIL1epsilon, FIL1zeta, and FIL1eta, with FIL1 standing for "Family of IL-1")...
  2. ncbi Identification and initial characterization of four novel members of the interleukin-1 family
    S Kumar
    Department of Bone and Cartilage Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Biol Chem 275:10308-14. 2000
    ..This suggests that IL-1H1 may be involved in pathogenesis of immune mediated disease processes. The addition of four novel IL-1 homologues suggests that the IL-1 family is significantly larger than previously thought...
  3. ncbi IL1HY1: A novel interleukin-1 receptor antagonist gene
    J J Mulero
    Functional Genomics Department, Immunology Group, Hyseq Inc, 670 Almanor Avenue, Sunnyvale, California 94086, USA
    Biochem Biophys Res Commun 263:702-6. 1999
    ..We have identified and characterized a novel member of the human interleukin-1 gene family (IL1HY1). The encoded protein demonstrates significant amino acid homology to the receptor antagonist (IL-1ra) at 52%...
  4. ncbi Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2
    R Debets
    DNAX Research Institute of Molecular and Cellular Biology, 901 California Avenue, Palo Alto, CA 94304, USA
    J Immunol 167:1440-6. 2001
    ....
  5. ncbi Genomic organization of the interleukin-1 locus
    Scott L Taylor
    Immunex Corporation, 51 University Street, Seattle, Washington 98101, USA
    Genomics 79:726-33. 2002
    ..There is a break in the mouse locus of > 100 kb, compared with the human locus, located between Il1b and the most centromere-proximal of the novel mouse genes. The mouse seems to be missing an ortholog of human IL1F7...
  6. pmc IL-36 promotes myeloid cell infiltration, activation, and inflammatory activity in skin
    Alexander M Foster
    Department of Dermatology, University of Michigan, Ann Arbor, MI 48109 and
    J Immunol 192:6053-61. 2014
    ..These data indicate that IL-36 cytokines actively propagate skin inflammation via the activation of keratinocytes, APC, and, indirectly, T cells. ..
  7. pmc IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression
    Andrew Johnston
    Department of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 186:2613-22. 2011
    ..Collectively, our data suggest important roles for these novel cytokines in inflammatory skin diseases and identify these peptides as potential targets for antipsoriatic therapies...
  8. pmc Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation
    Hal Blumberg
    Department of Inflammation, 2Department of Pathology, 3Department of Biostatistics, Amgen, Seattle, WA 98119, USA
    J Exp Med 204:2603-14. 2007
    ..Strikingly, the combination of the IL-1F6 transgene with an IL1F5 deficiency results in exacerbation of the skin phenotype, demonstrating that IL-1F5 has antagonistic activity in ..
  9. ncbi High-resolution structure of murine interleukin 1 homologue IL-1F5 reveals unique loop conformations for receptor binding specificity
    Eleanor F Dunn
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Biochemistry 42:10938-44. 2003
    ..These studies give insights into how distinct receptor specificities can evolve within related cytokine families...
  10. ncbi A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities
    J L Barton
    Division of Molecular and Genetic Medicine, University of Sheffield, Sheffield, GB
    Eur J Immunol 30:3299-308. 2000
    ..We conclude, contrary to a recent suggestion made by others, that IL-1L1 is not a functional IL-1ra. IL-1L1 also had no detectable agonistic or antagonistic effect on IFN-gamma production in response to IL-18 in KG-1 cells...
  11. doi IL-36R ligands are potent regulators of dendritic and T cells
    Solenne Vigne
    Division of Rheumatology and Department of Pathology Immunology, University of Geneva School of Medicine, Geneva, Switzerland
    Blood 118:5813-23. 2011
    ..Our data thus indicate a critical role of IL-36R ligands in the interface between innate and adaptive immunity, leading to the stimulation of T helper responses...
  12. pmc Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36α, IL-36β, and IL-36γ) or antagonist (IL-36Ra) activity
    Jennifer E Towne
    Department of Inflammation Research, Amgen Incorporated, Seattle, Washington 98119, USA
    J Biol Chem 286:42594-602. 2011
    ..In addition, truncation of IL-36α, IL-36β, and IL-36γ dramatically enhances their activity, suggesting that post-translational processing is required for full activity...
  13. doi IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells
    Solenne Vigne
    Division of Rheumatology, Department of Internal Medicine, University of Geneva School of Medicine, Switzerland
    Blood 120:3478-87. 2012
    ..Our findings point toward a critical function of IL-36 in the priming of Th1 cell responses in vitro, and in adaptive immunity in a model of mycobacterial infection in vivo...
  14. pmc Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalk
    Luigi Tortola
    Institute of Molecular Health Sciences, Molecular Biomedicine, Swiss Federal Institute of Technology ETH Zurich, Zurich, Switzerland
    J Clin Invest 122:3965-76. 2012
    ..Furthermore, IL-36R antagonist-deficient (Il36rn-/-) mice showed exacerbated pathology...
  15. pmc Cdk8 is essential for preimplantation mouse development
    Thomas Westerling
    Genome Scale Biology Program and Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, P O Box 63, 00014 Helsinki, Finland
    Mol Cell Biol 27:6177-82. 2007
    ..As Cdk8 deficiency in cultured metazoan cells did not affect cell viability, the results suggest that transcriptional repression of genes critical for early-cell-fate determination underlies the requirement of Cdk8 in embryogenesis...
  16. doi IL-1F5 mediates anti-inflammatory activity in the brain through induction of IL-4 following interaction with SIGIRR/TIR8
    Ceire Costelloe
    Trinity College Institute for Neuroscience, Trinity College, Dublin, Ireland
    J Neurochem 105:1960-9. 2008
    ..In contrast to its effects in brain tissue, IL-1F5 did not attenuate LPS-induced changes, or up-regulated IL-4 in macrophages or dendritic cells, suggesting that the effect is confined to the brain...
  17. doi Transient expression of ephrin b2 in perinatal skin is required for maintenance of keratinocyte homeostasis
    Gyohei Egawa
    Laboratory for Stem Cell Biology, RIKEN Center for Developmental Biology, Kobe, Japan
    J Invest Dermatol 129:2386-95. 2009
    ....