Il1b

Summary

Gene Symbol: Il1b
Description: interleukin 1 beta
Alias: IL-1beta, Il-1b, interleukin-1 beta, IL-1 beta
Species: mouse

Top Publications

  1. pmc Mice deficient in IL-1beta manifest impaired contact hypersensitivity to trinitrochlorobenzone
    L P Shornick
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Exp Med 183:1427-36. 1996
  2. doi T cell dependence of chronic destructive murine arthritis induced by repeated local activation of Toll-like receptor-driven pathways: crucial role of both interleukin-1beta and interleukin-17
    Leo A B Joosten
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 58:98-108. 2008
  3. pmc Pannexin-1-dependent caspase-1 activation and secretion of IL-1beta is regulated by zinc
    David Brough
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Eur J Immunol 39:352-8. 2009
  4. pmc Action of IL-1beta during fracture healing
    Jeffrey Lange
    Department of Orthopaedic Surgery, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Orthop Res 28:778-84. 2010
  5. pmc Exacerbation of CNS inflammation and neurodegeneration by systemic LPS treatment is independent of circulating IL-1β and IL-6
    Carol L Murray
    School of Biochemistry and Immunology, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    J Neuroinflammation 8:50. 2011
  6. ncbi Biologic basis for interleukin-1 in disease
    C A Dinarello
    Department of Medicine, Tufts University, Boston, MA USA
    Blood 87:2095-147. 1996
  7. pmc Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction
    Chong Shan Shi
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 13:255-63. 2012
  8. doi Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1
    Olaf Gross
    Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
    Immunity 36:388-400. 2012
  9. pmc Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine
    Michael H Shaw
    Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Exp Med 209:251-8. 2012
  10. pmc Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β
    Nicolas Dupont
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
    EMBO J 30:4701-11. 2011

Detail Information

Publications191 found, 100 shown here

  1. pmc Mice deficient in IL-1beta manifest impaired contact hypersensitivity to trinitrochlorobenzone
    L P Shornick
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Exp Med 183:1427-36. 1996
    ..They suggest an important role for IL-1beta in initiation of the host of response at the epidermal barrier...
  2. doi T cell dependence of chronic destructive murine arthritis induced by repeated local activation of Toll-like receptor-driven pathways: crucial role of both interleukin-1beta and interleukin-17
    Leo A B Joosten
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 58:98-108. 2008
    ..The present study was undertaken to develop a mouse model of chronic destructive arthritis induced by repeated intraarticular (IA) exposure to bacterial cell wall fragments and to investigate the cytokine dependence of this model...
  3. pmc Pannexin-1-dependent caspase-1 activation and secretion of IL-1beta is regulated by zinc
    David Brough
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Eur J Immunol 39:352-8. 2009
    ..These data provide new insights into the mechanisms of caspase-1 activation and how zinc metabolism contributes to inflammatory mechanisms...
  4. pmc Action of IL-1beta during fracture healing
    Jeffrey Lange
    Department of Orthopaedic Surgery, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Orthop Res 28:778-84. 2010
    ..These changes could reflect a slight acceleration of endochondral ossification, or direct effects on cartilage and bone formation...
  5. pmc Exacerbation of CNS inflammation and neurodegeneration by systemic LPS treatment is independent of circulating IL-1β and IL-6
    Carol L Murray
    School of Biochemistry and Immunology, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland
    J Neuroinflammation 8:50. 2011
    ..Here we investigated whether inhibition of systemic cytokine synthesis using the anti-inflammatory steroid dexamethasone-21-phosphate was sufficient to block any or all of these responses...
  6. ncbi Biologic basis for interleukin-1 in disease
    C A Dinarello
    Department of Medicine, Tufts University, Boston, MA USA
    Blood 87:2095-147. 1996
    ..At the end of each section, a short commentary summarizes what the author considers established or controversial topics linking the biology of IL-1 to mechanisms of disease...
  7. pmc Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction
    Chong Shan Shi
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 13:255-63. 2012
    ..Our data indicate that autophagy accompanies inflammasome activation to temper inflammation by eliminating active inflammasomes...
  8. doi Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1
    Olaf Gross
    Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
    Immunity 36:388-400. 2012
    ..Because inflammasomes contribute to the pathology of numerous chronic inflammatory diseases such as gout and diabetes, IL-1α antagonists may be beneficial in the treatment of these disorders...
  9. pmc Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine
    Michael H Shaw
    Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Exp Med 209:251-8. 2012
    ..Thus, commensal-induced IL-1β production is a critical step for sT(H)17 differentiation in the intestine, which may have therapeutic implications for T(H)17-mediated pathologies...
  10. pmc Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β
    Nicolas Dupont
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
    EMBO J 30:4701-11. 2011
    ..It enables a subset of cytosolic proteins devoid of signal peptide sequences, and thus unable to access the conventional pathway through the ER, to enter an autophagy-based secretory pathway facilitating their exit from the cytoplasm...
  11. pmc Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
    Edward A Miao
    Institute for Systems Biology, Seattle, Washington, USA
    Nat Immunol 11:1136-42. 2010
    ..This demonstrates that activation of caspase-1 clears intracellular bacteria in vivo independently of IL-1β and IL-18 and establishes pyroptosis as an efficient mechanism of bacterial clearance by the innate immune system...
  12. ncbi Inhibition of caspase-1/interleukin-1beta signaling prevents degeneration of retinal capillaries in diabetes and galactosemia
    Jason A Vincent
    Case Western Reserve University, Department of Medicine, Division of Clinical and Molecular Endocrinology, Center for Diabetes Research, Cleveland, OH 44106, USA
    Diabetes 56:224-30. 2007
    ....
  13. doi Cutting edge: crucial role of IL-1 and IL-23 in the innate IL-17 response of peripheral lymph node NK1.1- invariant NKT cells to bacteria
    Jean Marc Doisne
    INSERM U561, Hôpital Cochin St Vincent de Paul, Universite Rene Descartes, 75014 Paris, France
    J Immunol 186:662-6. 2011
    ..1(-) iNKT cells could be a source of innate Th17-related cytokines during bacterial infections and supports the hypothesis that they are able to provide an efficient first line of defense against bacterial invasion...
  14. pmc IL-1 is required for tumor invasiveness and angiogenesis
    Elena Voronov
    Department of Microbiology and Immunology, Faculty of Health Sciences, The Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Proc Natl Acad Sci U S A 100:2645-50. 2003
    ..Furthermore, the anti-angiogenic effects of IL-1 receptor antagonist, shown here, suggest a possible therapeutic role in cancer, in addition to its current use in rheumatoid arthritis...
  15. doi The inflammasome sensor, NLRP3, regulates CNS inflammation and demyelination via caspase-1 and interleukin-18
    SUSHMITA JHA
    Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA
    J Neurosci 30:15811-20. 2010
    ..Additionally, the therapeutic inhibition of IL-18 might decrease demyelination but enhance remyelination, which has broad implications for demyelinating diseases...
  16. doi Caspase-1-processed cytokines IL-1beta and IL-18 promote IL-17 production by gammadelta and CD4 T cells that mediate autoimmunity
    Stephen J Lalor
    School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    J Immunol 186:5738-48. 2011
    ....
  17. pmc Inflammasome activation and IL-1β target IL-1α for secretion as opposed to surface expression
    Antonia Fettelschoss
    Department of Dermatology, Zurich University Hospital, 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 108:18055-60. 2011
    ..We further demonstrate that IL-1β directly binds IL-1α, thus identifying IL-1β as a shuttle for another proinflammatory cytokine. These results have direct impact on selective treatment modalities of inflammatory diseases...
  18. pmc IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells
    Margherita Coccia
    Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, England, UK
    J Exp Med 209:1595-609. 2012
    ..These data identify multiple mechanisms through which IL-1β promotes intestinal pathology and suggest that targeting IL-1β may represent a useful therapeutic approach in IBD...
  19. pmc TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autophagosome maturation
    Manohar Pilli
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA
    Immunity 37:223-34. 2012
    ..Thus, TBK-1 is a key regulator of immunological autophagy and is responsible for the maturation of autophagosomes into lytic bactericidal organelles...
  20. pmc IL-1 plays an important role in lipid metabolism by regulating insulin levels under physiological conditions
    Taizo Matsuki
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Exp Med 198:877-88. 2003
    ..These observations suggest that IL-1 plays an important role in lipid metabolism by regulating insulin levels and lipase activity under physiological conditions...
  21. pmc IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells
    Liying Guo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:13463-8. 2009
    ....
  22. pmc Interleukin-1α expression precedes IL-1β after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues
    Nadia M Luheshi
    University of Manchester, UK
    J Neuroinflammation 8:186. 2011
    ..In order to determine this we investigated the temporal and spatial profiles of IL-1α and IL-1β expression after cerebral ischemia...
  23. pmc Inflammasome-dependent pyroptosis and IL-18 protect against Burkholderia pseudomallei lung infection while IL-1β is deleterious
    Ivonne Ceballos-Olvera
    Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
    PLoS Pathog 7:e1002452. 2011
    ..Thus, the NLRP3 and NLRC4 inflammasomes have non-redundant protective roles in melioidosis: NLRC4 regulates pyroptosis while NLRP3 regulates production of protective IL-18 and deleterious IL-1β...
  24. ncbi Differential effects of IL-1 alpha and IL-1 beta on tumorigenicity patterns and invasiveness
    Xiaoping Song
    Department of Microbiology and Immunology, Faculty of Health Sciences, The Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Immunol 171:6448-56. 2003
    ....
  25. pmc Caspase-1-mediated activation of interleukin-1beta (IL-1beta) and IL-18 contributes to innate immune defenses against Salmonella enterica serovar Typhimurium infection
    Barbel Raupach
    Department of Cellular Microbiology, Max Planck Institut für Infektionsbiologie, Schumannstrasse 21 22, 10117 Berlin, Germany
    Infect Immun 74:4922-6. 2006
    ..Thus, we show that Casp-1 is essential for host innate immune defense against S. enterica serovar Typhimurium and that Casp-1 substrates are required at distinct times and anatomical sites...
  26. pmc The inflammatory cytokine, interleukin-1 beta, mediates loss of astroglial glutamate transport and drives excitotoxic motor neuron injury in the spinal cord during acute viral encephalomyelitis
    Natalie A Prow
    Department of Microbiology and Parasitology, The University of Queensland, Brisbane, Australia
    J Neurochem 105:1276-86. 2008
    ..They provide one of the strongest in vivo links between innate immune responses and the development of excitotoxicity demonstrated to date...
  27. pmc Mutant superoxide dismutase 1-induced IL-1beta accelerates ALS pathogenesis
    Felix Meissner
    Department of Cellular Microbiology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany
    Proc Natl Acad Sci U S A 107:13046-50. 2010
    ..These findings identify microglial IL-1beta as a causative event of neuroinflammation and suggest IL-1 as a potential therapeutic target in ALS...
  28. pmc JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis
    Monica Guma
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Pathology, Division of Rheumatology, School of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 107:22122-7. 2010
    ..Hence, JNK1 controls mast cell degranulation and FcγR-triggered IL-1β production, in addition to regulating cytokine and matrix metalloproteinase biosynthesis, and is an attractive therapeutic target in inflammatory arthritis...
  29. doi Monoclonal antibodies targeting IL-1 beta reduce biomarkers of atherosclerosis in vitro and inhibit atherosclerotic plaque formation in Apolipoprotein E-deficient mice
    Vinay Bhaskar
    Preclinical Research, XOMA US LLC, 2910 Seventh Street, Berkeley, CA 94710, USA
    Atherosclerosis 216:313-20. 2011
    ....
  30. ncbi Central nervous system-initiated inflammation and neurotrophism in trauma: IL-1 beta is required for the production of ciliary neurotrophic factor
    L M Herx
    Departments of Clinical Neurosciences and Oncology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Immunol 165:2232-9. 2000
    ..These findings provide the first evidence of the requirement for IL-1beta in the production of CNTF following CNS trauma, and suggest that inflammation can have a beneficial impact on the regenerative capacity of the CNS...
  31. pmc Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation
    Yihui Fan
    Laboratory of Medical Genetics, Harbin Medical University, Harbin 150081, China
    J Biol Chem 285:5347-60. 2010
    ....
  32. pmc Burkholderia cenocepacia O polysaccharide chain contributes to caspase-1-dependent IL-1beta production in macrophages
    Sheetal Kotrange
    Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Center for Microbial Interface Biology and the Department of Internal Medicine, Ohio State University, Columbus, Ohio 43210, USA
    J Leukoc Biol 89:481-8. 2011
    ..Taken together, we identified eukaryotic and bacterial factors that contribute to inflammation during B. cenocepacia infection, which may aid in the design of novel approaches to control pulmonary inflammation...
  33. ncbi Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1 beta on long term potentiation in rat dentate gyrus
    Aine Kelly
    Trinity College Institute of Neuroscience, Department of Physiology, Dublin 2, Ireland
    J Biol Chem 278:19453-62. 2003
    ..The evidence is consistent with the idea that the LPS-induced impairment in LTP is mediated by IL-1 beta and is a consequence of activation of p38...
  34. ncbi Tumor necrosis factor-alpha and interleukin-1 beta play a critical role in the resistance against lethal herpes simplex virus encephalitis
    Yan Sergerie
    Research Center in Infectious Diseases, Centre Hospitalier Universitaire de Quebec Centre Hospitalier de l Universite Laval, Laval University, Quebec City, Quebec, Canada
    J Infect Dis 196:853-60. 2007
    ..We investigated the role of the innate immune response in such infection using a C57BL/6 mouse knockout (KO) model for tumor necrosis factor (TNF)-alpha and/or interleukin (IL)-1beta...
  35. doi The role of macrophage-derived IL-1 in induction and maintenance of angiogenesis
    Yaron Carmi
    The Shraga Segal Department of Microbiology and Immunology and The Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    J Immunol 183:4705-14. 2009
    ..Thus, targeting IL-1beta has the potential to inhibit angiogenesis in pathological situations and may be of considerable clinical value...
  36. doi Long-term exposure to IL-1beta enhances Toll-IL-1 receptor-mediated inflammatory signaling in murine airway hyperresponsiveness
    Yaping Zhang
    Division of ENT Diseases, Department of CLINTEC, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden
    Eur Cytokine Netw 20:148-56. 2009
    ..Understanding cytokine-induced activation of the Toll-IL-1 receptor-mediated inflammatory signaling mechanisms may provide new options for the treatment of airway inflammation and AHR...
  37. doi Basic calcium phosphate crystals induce monocyte/macrophage IL-1β secretion through the NLRP3 inflammasome in vitro
    Borbála Pazár
    Department of Rheumatology, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    J Immunol 186:2495-502. 2011
    ..Furthermore, we speculate that IL-1 blockade could be a novel strategy to inhibit BCP-induced inflammation in human disease...
  38. pmc Protective role of IL-1β against post-arthroplasty Staphylococcus aureus infection
    Nicholas M Bernthal
    Orthopaedic Hospital Research Center, Orthopaedic Hospital Department of Orthopaedic Surgery, David Geffen School of Medicine at University of California, Los Angeles, California, USA
    J Orthop Res 29:1621-6. 2011
    ..Taken together, these findings suggest a mechanism by which IL-1β induces neutrophil recruitment to help control the bacterial burden and the ensuing biofilm formation in a post-surgical joint...
  39. pmc Caspase-1 dependent IL-1β secretion is critical for host defense in a mouse model of Chlamydia pneumoniae lung infection
    Kenichi Shimada
    Division of Pediatrics Infectious Disease and Immunology, Cedars Sinai Medical Center and David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 6:e21477. 2011
    ..Interestingly, Caspase-1 activation during CP infection occurs with mitochondrial dysfunction indicating a possible mechanism involving the mitochondria for CP-induced inflammasome activation...
  40. pmc IL-1 and IL-23 mediate early IL-17A production in pulmonary inflammation leading to late fibrosis
    Pamela Gasse
    University of Orleans and CNRS, UMR6218, Orleans, France
    PLoS ONE 6:e23185. 2011
    ..We demonstrated recently the predominant role of the NLRP3 inflammasome activation and IL-1β expression in the establishment of pulmonary inflammation and fibrosis in mice...
  41. doi Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1β and TNF: implications for neuropathic pain
    Sylvain Nadeau
    Centre de recherche du Centre hospitalier de l Université Laval and Department of Molecular Medicine, Universite Laval, Quebec, G1V 4G2, Canada
    J Neurosci 31:12533-42. 2011
    ....
  42. pmc Autophagy suppresses interleukin-1β (IL-1β) signaling by activation of p62 degradation via lysosomal and proteasomal pathways
    Jongdae Lee
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0663, USA
    J Biol Chem 287:4033-40. 2012
    ..Taken together our data indicate that loss-of-function of ATG16L1 results in a hyper-responsiveness to the IL-1β signaling because of the increased p62 level...
  43. pmc Interleukin-1 stimulates ADAM17 through a mechanism independent of its cytoplasmic domain or phosphorylation at threonine 735
    Katherine C Hall
    Arthritis and Tissue Degeneration Program, The Hospital for Special Surgery, New York, New York, United States of America
    PLoS ONE 7:e31600. 2012
    ....
  44. doi Autophagy regulates IL-23 secretion and innate T cell responses through effects on IL-1 secretion
    Celia Peral de Castro
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin 2, Ireland
    J Immunol 189:4144-53. 2012
    ..These data demonstrate that autophagy has a potentially pivotal role to play in the induction and regulation of inflammatory responses by innate immune cells, largely driven by IL-1 and its consequential effects on IL-23 secretion...
  45. pmc Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1β
    Bibhuti B Mishra
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nat Immunol 14:52-60. 2013
    ..Our data indicate that the NO produced as a result of adaptive immunity is indispensable in modulating the destructive innate inflammatory responses elicited during persistent infections...
  46. ncbi Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages
    Marja Ojaniemi
    Biocenter Oulu and Department of Pediatrics, University of Oulu, PO Box 5000, FIN 90014 Oulu, Finland
    Eur J Immunol 33:597-605. 2003
    ..Taken together, our results demonstrate that activation of Toll-like receptor (TLR)-4 results in PI 3-kinase-MyD88 complex formation, and that PI 3-kinase activity selectively leads to cytokine induction downstream of TLR4...
  47. ncbi Glucagon-like peptide-1 inhibits LPS-induced IL-1beta production in cultured rat astrocytes
    Takashi Iwai
    Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278 8510, Japan
    Neurosci Res 55:352-60. 2006
    ..GLP-1 also increased cAMP concentration and cAMP response element-binding protein phosphorylation in astrocytes. These results suggest that GLP-1 may be a modulator of inflammation in the central nervous system...
  48. pmc Interleukin-1 stimulates catabolism in C2C12 myotubes
    Wei Li
    Department of Physiology, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    Am J Physiol Cell Physiol 297:C706-14. 2009
    ....
  49. pmc A role for IL-18 in protective immunity against Mycobacterium tuberculosis
    Bianca E Schneider
    London School of Hygiene and Tropical Medicine, Infectious and Tropical Diseases Immunology, London, UK
    Eur J Immunol 40:396-405. 2010
    ..Thus, IL-18 plays a decisive role in protective immunity against tuberculosis...
  50. pmc IL-1β regulates a novel myeloid-derived suppressor cell subset that impairs NK cell development and function
    Moshe Elkabets
    Innate Immunity Unit, Institut Pasteur, Paris, France
    Eur J Immunol 40:3347-57. 2010
    ..These results identify a novel IL-1β-induced subset of MDSC with unique functional properties. Ly6C(neg) MDSC mediating NK cell suppression may thus represent useful targets for therapeutic interventions...
  51. ncbi Protective role of interleukin-1 in mycobacterial infection in IL-1 alpha/beta double-knockout mice
    H Yamada
    Department of Molecular Pathology, The Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, Kiyose, Tokyo
    Lab Invest 80:759-67. 2000
    ..Our data clearly indicate that IL-1 is important for the generation of early-phase protective immunity against mycobacterial infection...
  52. ncbi Mechanism for IL-1 beta-mediated neovascularization unmasked by IL-1 beta knock-out mice
    Katsuya Amano
    Department of Medicine II and Cardiovascular Center, Kansai Medical University, 10 15 Fumizono cho, Moriguchi, Osaka 570 8507, Japan
    J Mol Cell Cardiol 36:469-80. 2004
    ....
  53. ncbi Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing
    Shin Maeda
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0723, USA
    Science 307:734-8. 2005
    ..These effects are linked to increased susceptibility to bacterial-induced intestinal inflammation and identify NOD2 as a positive regulator of NF-kappaB activation and IL-1beta secretion...
  54. pmc The Pseudomonas aeruginosa Type III secretion system plays a dual role in the regulation of caspase-1 mediated IL-1beta maturation
    M Galle
    Department of Molecular Biology, Ghent University, Ghent, Belgium
    J Cell Mol Med 12:1767-76. 2008
    ..Altogether, these data demonstrate a dual role for the P. aeruginosa T3SS in the regulation of Caspase-1 mediated IL-1beta production and provide new insights into the mechanisms of immune evasion by this pathogen...
  55. pmc Neuropeptide Y modulation of interleukin-1{beta} (IL-1{beta})-induced nitric oxide production in microglia
    Raquel Ferreira
    Center for Neuroscience and Cell Biology, University of Coimbra, 3004 504 Coimbra, Portugal
    J Biol Chem 285:41921-34. 2010
    ..The role of NPY in key inflammatory events may contribute to unravel novel gateways to modulate inflammation associated with brain pathology...
  56. pmc Staphylococcus aureus evades lysozyme-based peptidoglycan digestion that links phagocytosis, inflammasome activation, and IL-1beta secretion
    Takahiro Shimada
    Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Cell Host Microbe 7:38-49. 2010
    ..aureus are functionally coupled to inflammasome activation and IL-1beta secretion and illustrate a case whereby a bacterium specifically subverts IL-1beta secretion through chemical modification of its cell wall PGN...
  57. ncbi Altered cytokine production in mice lacking P2X(7) receptors
    M Solle
    Department of Respiratory, Allergy, Immunology, Inflammation, and Infectious Diseases, Pfizer Inc, Groton, Connecticut 06340, USA
    J Biol Chem 276:125-32. 2001
    ..Together these results demonstrate that P2X(7)R activation can provide a signal that leads to maturation and release of IL-1 beta and initiation of a cytokine cascade...
  58. ncbi Resistance to fever induction and impaired acute-phase response in interleukin-1 beta-deficient mice
    H Zheng
    Department of Genetics and Molecular Biology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Immunity 3:9-19. 1995
    ....
  59. ncbi Caspase 1-independent IL-1beta release and inflammation induced by the apoptosis inducer Fas ligand
    K Miwa
    Osaka Bioscience Institute, Department of Molecular Biology, Suita, Japan
    Nat Med 4:1287-92. 1998
    ..These results demonstrate a newly discovered role for Fas ligand in inflammation, and challenge the dogma that apoptosis does not induce inflammation...
  60. pmc Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice
    Hiroshi Hata
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, 53 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    J Clin Invest 114:582-8. 2004
    ..The results also indicate that targeting not only each cytokine but also each cell population secreting distinct cytokines could be an effective treatment of rheumatoid arthritis...
  61. ncbi The potential role of SOCS-3 in the interleukin-1beta-induced desensitization of insulin signaling in pancreatic beta-cells
    Brice Emanuelli
    INSERM U145, IFR 50, Faculty of Medicine, 06107 Nice Cedex 2 France
    Diabetes 53:S97-S103. 2004
    ..We propose that IL-1beta decreases insulin action in beta-cells through the induction of SOCS-3 expression, and that this effect potentially alters insulin-induced beta-cell survival...
  62. ncbi Inhibitory effects of chloride on the activation of caspase-1, IL-1beta secretion, and cytolysis by the P2X7 receptor
    Philip A Verhoef
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4970, USA
    J Immunol 175:7623-34. 2005
    ..These results suggest that under physiological conditions P2X7R are maintained in a conformationally restrained state that limits channel gating and coupling of the receptor to signaling pathways that regulate caspase-1...
  63. pmc The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta
    Ksenya Shchors
    Cancer Research Institute and Department of Cellular and Molecular Pharmacology, University of California at San Francisco Comprehensive Cancer Center, 94143, USA
    Genes Dev 20:2527-38. 2006
    ..Together, our data delineate a complete pathway in vivo by which the highly pleiotropic Myc oncoproteins elicits coexpansion of the vascular compartment during tumorigenic progression...
  64. ncbi Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death
    David Brough
    Faculty of Life Sciences, Michael Smith Building, University of Manchester, Oxford Road, Manchester, M13 9PT, UK
    J Cell Sci 120:772-81. 2007
    ..We propose that, in macrophages, ATP-induced interleukin-1beta processing occurs in the cytosol by a mechanism that resembles pyroptosis...
  65. pmc NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta
    Florian R Greten
    Second Department of Medicine, Klinikum rechts der Isar, Technical University Munich, 81675 Germany
    Cell 130:918-31. 2007
    ..These results unravel an unanticipated role for IKKbeta-dependent NF-kappaB signaling in the negative control of IL-1beta production and highlight potential complications of long-term IKKbeta inhibition...
  66. ncbi P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage
    Pablo Pelegrin
    Faculty of Life Science, University of Manchester, Manchester, United Kingdom
    J Immunol 180:7147-57. 2008
    ..None of these release responses were associated with cell damage or cytolytic effects. This provides the first direct demonstration of a distinct signaling mechanism responsible for ATP-induced release of pro-IL-1beta...
  67. ncbi Macrophage and monocyte IL-1 beta regulation differs at multiple sites. Messenger RNA expression, translation, and post-translational processing
    D J Herzyk
    Department of Internal Medicine, Ohio State University, Columbus 43210
    J Immunol 149:3052-8. 1992
    ....
  68. ncbi Effect of endotoxin in IL-1 beta-deficient mice
    G Fantuzzi
    Department of Medicine, Tufts University School of Medicine, Boston, MA 02111, USA
    J Immunol 157:291-6. 1996
    ..In summary, our results suggest that either IL-1 beta is not essential for the in vivo systemic response to LPS or that its role can be fulfilled by other cytokines with overlapping activities...
  69. pmc Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion
    R Horai
    Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108, Japan
    J Exp Med 187:1463-75. 1998
    ..The importance of IL-1ra both in normal physiology and under stress is also suggested...
  70. ncbi Role of IL-1alpha and IL-1beta in ischemic brain damage
    H Boutin
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Neurosci 21:5528-34. 2001
    ....
  71. ncbi Interleukin-1 beta is required for the early evolution of reactive astrogliosis following CNS lesion
    L M Herx
    Department of Clinical Neurosciences and Oncology, Faculty of Medicine, University of Calgary, Alberta, Canada
    J Neuropathol Exp Neurol 60:961-71. 2001
    ..These findings suggest that the rapid production of IL-1beta following trauma plays a beneficial role in initiating astrogliosis in an attempt to restore the integrity of the BBB and seal off the wound site...
  72. ncbi IL-1 is required for allergen-specific Th2 cell activation and the development of airway hypersensitivity response
    Susumu Nakae
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Int Immunol 15:483-90. 2003
    ..These observations indicate that IL-1 plays important roles in the development of AHR...
  73. ncbi Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes
    C Lagathu
    INSERM, U680, Université Pierre et Marie Curie UPMC Paris 6, Faculty of Medicine, 27 rue Chaligny, 75012, Paris, France
    Diabetologia 49:2162-73. 2006
    Adipose tissue inflammation has recently been implicated in the pathogenesis of insulin resistance and is probably linked to high local levels of cytokines. IL1B, a proinflammatory cytokine, may participate in this alteration.
  74. ncbi Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo
    Lloyd S Miller
    Division of Dermatology, University of California, Los Angeles, CA 90095, USA
    J Immunol 179:6933-42. 2007
    ..aureus in vivo...
  75. pmc Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms
    Michael T Ganter
    Laboratory of Surgical Research, Department of Anesthesia, University of California, San Francisco 94110, USA
    Circ Res 102:804-12. 2008
    ..In summary, these results demonstrate a critical role for the alphavbeta5/beta6 integrins in mediating the IL-1beta-induced ALI and indicate that these integrins could be a potentially attractive therapeutic target in ALI...
  76. pmc Bacillus anthracis spores and lethal toxin induce IL-1beta via functionally distinct signaling pathways
    Tae Jin Kang
    Center for Vaccine Development, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Eur J Immunol 38:1574-84. 2008
    ..Thus different components of the same bacterium each induce IL-1beta by distinct signaling pathways. Whereas the spore-induced IL-1beta limits BA infection, LT-induced IL-1beta enables BA to escape host defenses...
  77. pmc The NALP3 inflammasome is involved in the innate immune response to amyloid-beta
    Annett Halle
    Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Immunol 9:857-65. 2008
    The fibrillar peptide amyloid-beta (A beta) has a chief function in the pathogenesis of Alzheimer's disease. Interleukin 1 beta (IL-1 beta) is a key cytokine in the inflammatory response to A beta...
  78. pmc Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice
    Bettina H Clausen
    Medical Biotechnology Center, University of Southern Denmark, Odense, Denmark
    J Neuroinflammation 5:46. 2008
    ..We investigated whether IL-1beta and TNF-alpha are synthesized by overlapping or segregated populations of cells after ischemic stroke in mice...
  79. doi Bypassing pathogen-induced inflammasome activation for the regulation of interleukin-1beta production by the fungal pathogen Candida albicans
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Infect Dis 199:1087-96. 2009
    ..The aim of the present study was to investigate the pathways of IL-1beta production induced by Candida albicans in human monocytes...
  80. pmc Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo
    Nelson C Di Paolo
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Immunity 31:110-21. 2009
    ..Thus, these data identify IL-1 alpha-IL-1RI as a key pathway allowing for the activation of proinflammatory responses to the virus, independently of its genomic nucleic acid recognition...
  81. pmc NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
    Peter Duewell
    Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 464:1357-61. 2010
    ..These findings provide new insights into the pathogenesis of atherosclerosis and indicate new potential molecular targets for the therapy of this disease...
  82. doi Inflammasome activation by adenylate cyclase toxin directs Th17 responses and protection against Bordetella pertussis
    Aisling Dunne
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity College, Dublin, Ireland
    J Immunol 185:1711-9. 2010
    ..In addition to its known role in subverting host immunity, our findings suggest that CyaA can promote IL-1beta-mediated Th17 cells, which promote clearance of the bacteria from the respiratory tract...
  83. doi IL-1 plays an important role in the bone metabolism under physiological conditions
    Young Mi Lee
    Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Int Immunol 22:805-16. 2010
    ..Taken together, these results indicate that IL-1 directly activates RANK signaling other than inducing RANKL to promote osteoclastogenesis and plays an important role in physiological bone metabolism...
  84. pmc Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis
    Richard C Chou
    Division of Rheumatology, Allergy, and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Immunity 33:266-78. 2010
    ....
  85. pmc Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation
    James Harris
    Adjuvant Research Group, School of Biochemistry and Immunology, Trinity College Dublin, College Green, Dublin 2, Ireland
    J Biol Chem 286:9587-97. 2011
    ..These data demonstrate that autophagy controls the production of IL-1β through at least two separate mechanisms: by targeting pro-IL-1β for lysosomal degradation and by regulating activation of the NLRP3 inflammasome...
  86. doi Microenvironment-derived IL-1 and IL-17 interact in the control of lung metastasis
    Yaron Carmi
    Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences and National Institute of Biotechnology, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Immunol 186:3462-71. 2011
    ..Also, we suggest that intervention in IL-1/IL-17 production could be therapeutically used to tilt this balance toward enhanced antitumor immunity...
  87. doi NLRP3/caspase-1-independent IL-1beta production mediates diesel exhaust particle-induced pulmonary inflammation
    Sharen Provoost
    Department of Respiratory Medicine, Laboratory for Translational Research in Obstructive Pulmonary Diseases, Ghent University Hospital, 9000 Ghent, Belgium
    J Immunol 187:3331-7. 2011
    ..In addition, DEP initiates inflammation independent of the classical NLRP3/caspase-1 pathway, suggesting that other proteases might be involved...
  88. doi IL-1α and IL-1β recruit different myeloid cells and promote different stages of sterile inflammation
    Peleg Rider
    The Shraga Segal Department of Microbiology and Immunology and The Cancer Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    J Immunol 187:4835-43. 2011
    ..Overall, our data provide new insight into the biology of IL-1 molecules as well as on the regulation of sterile inflammation...
  89. doi The NLRP3/ASC/Caspase-1 axis regulates IL-1β processing in neutrophils
    Arun K Mankan
    Institute for Clinical Chemistry and Clinical Pharmacology, Unit for Clinical Biochemistry, University Hospital, University of Bonn, Bonn, Germany
    Eur J Immunol 42:710-5. 2012
    ..Our findings establish the NLRP3 inflammasome as a key step in the secretion of matured IL-1β by neutrophils...
  90. doi Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation
    James E Vince
    Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
    Immunity 36:215-27. 2012
    ....
  91. pmc Cutting edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in an RIP3-independent manner
    Lukas Bossaller
    Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 189:5508-12. 2012
    ..Hence, Fas controls a novel noncanonical IL-1β activation pathway in myeloid cells, which could play an essential role in inflammatory processes, tumor surveillance, and control of infectious diseases...
  92. pmc Proapoptotic chemotherapeutic drugs induce noncanonical processing and release of IL-1β via caspase-8 in dendritic cells
    Christina Antonopoulos
    Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106
    J Immunol 191:4789-803. 2013
    ....
  93. ncbi The inflammatory response in interleukin-1 beta-deficient mice: comparison with other cytokine-related knock-out mice
    G Fantuzzi
    Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA
    J Leukoc Biol 59:489-93. 1996
    ....
  94. ncbi An essential role of interleukin-1beta in mediating NF-kappaB activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia
    N Laflamme
    Laboratory of Molecular Endocrinology, Centre de Recherche de l Université Laval Research Center, Department of Anatomy, Laval University, Quebec, Canada G1V 4G2
    J Neurosci 19:10923-30. 1999
    ....
  95. pmc Interleukin-1 beta, but not interleukin-1 alpha, is required for T-cell-dependent antibody production
    S Nakae
    Centre for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Immunology 104:402-9. 2001
    ..These results show that endogenous IL-1 beta, but not IL-1 alpha, is involved in T-cell-dependent antibody production, and IL-1 promotes the antigen-specific T-cell helper function through the T-cell-APC interaction...
  96. pmc Leukocyte-derived interleukin-1beta interacts with renal interleukin-1 receptor I to promote renal tumor necrosis factor and glomerular injury in murine crescentic glomerulonephritis
    Jennifer R Timoshanko
    Department of Medicine, Centre for Inflammatory Diseases, Monash Medical Centre, Monash University, Clayton, Victoria, Australia
    Am J Pathol 164:1967-77. 2004
    ..These studies demonstrate that leukocytes are the major cellular source of IL-1beta, and that IL-1beta acts principally via the IL-1RI on intrinsic renal cells to induce TNF expression and crescentic glomerular injury...
  97. ncbi Chlamydia pneumoniae stimulates IFN-gamma synthesis through MyD88-dependent, TLR2- and TLR4-independent induction of IL-18 release
    Mihai G Netea
    Department of Medicine, University Medical Center Nijmegen, The Netherlands
    J Immunol 173:1477-82. 2004
    ..Most interestingly, C. pneumoniae is also a potent inducer of IL-18 production through pathways independent of TLR2 and TLR4...
  98. ncbi Compensatory response of IL-1 gene knockout mice after pulmonary infection with Klebsiella pneumoniae
    Masaaki Tanabe
    Department of Microbiology, Omori Hospital, Toho University School of Medicine, 5 21 16 Omori nishi, Ota ku Tokyo, Japan
    J Med Microbiol 54:7-13. 2005
    ..The data suggest that compensatory production of TNF-alpha in IL-1 KO mice contributes to the host defence against K. pneumoniae infection...
  99. ncbi Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA
    Thirumala Devi Kanneganti
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 281:36560-8. 2006
    ..These results identify a mechanism mediated by cryopyrin and ASC that links dsRNA and viral infection to caspase-1 activation resulting in IL-1beta and IL-18 production...
  100. pmc Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression
    Jennifer Jager
    Institut National de la Santé et de la Recherche Médicale INSERM U568, Faculty of Medicine, Avenue de Valombrose, 06107 Nice Cedex 2, France
    Endocrinology 148:241-51. 2007
    ..By targeting IRS-1, IL-1beta is capable of impairing insulin signaling and action, and could thus participate in concert with other cytokines, in the development of insulin resistance in adipocytes...
  101. ncbi Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages
    Yan Qu
    Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44120, USA
    J Immunol 179:1913-25. 2007
    ..Our findings suggest an alternative model of IL-1 beta release that may involve the P2X7R-induced formation of multivesicular bodies that contain exosomes with entrapped IL-1 beta, caspase-1, and other inflammasome components...

Research Grants6

  1. Pathogenic Mechanisms of TMEV-induced Demyelination
    Byung Kim; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  2. Role of CNS CD4+ T cells in TMEV-induced Demyelination
    Byung Kim; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  3. Investigation of Nod2: Implications for Uveitis
    Holly Rosenzweig; Fiscal Year: 2008
    ..Together, these studies will provide valuable new information on how Nod2 is involved in autoimmunity and the pathogeneis of uveitis. ..
  4. Innate Immune Detection of Intracellular Pathogens
    RUSSELL VANCE; Fiscal Year: 2005
    ....
  5. HSP25 and HSP20 Regulation in Skeletal Muscle Adapt
    KIMBERLY HUEY; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  6. Innate immune resistance to intracellular bacterial pathogens
    RUSSELL VANCE; Fiscal Year: 2007
    ..Such knowledge should contribute to rational approaches to designing novel antibacterial therapies. [unreadable] [unreadable] [unreadable]..