Il1a

Summary

Gene Symbol: Il1a
Description: interleukin 1 alpha
Alias: Il-1a, interleukin-1 alpha, IL-1 alpha
Species: mouse

Top Publications

  1. ncbi Biologic basis for interleukin-1 in disease
    C A Dinarello
    Department of Medicine, Tufts University, Boston, MA USA
    Blood 87:2095-147. 1996
  2. pmc Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β
    Amir S Yazdi
    Department of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    Proc Natl Acad Sci U S A 107:19449-54. 2010
  3. pmc Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators
    D Caput
    Proc Natl Acad Sci U S A 83:1670-4. 1986
  4. doi Sialylation of 3-methylcholanthrene-induced fibrosarcoma determines antitumor immune responses during immunoediting
    Merav Cohen
    Department of Biotechnology Engineering, Faculty of Engineering, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Immunol 185:5869-78. 2010
  5. ncbi Interleukin-1 alpha and beta genes: linkage on chromosome 2 in the mouse
    P D'Eustachio
    Department of Biochemistry, New York University Medical Center, NY 10016
    Immunogenetics 26:339-43. 1987
  6. ncbi Cloning and expression of murine interleukin-1 cDNA in Escherichia coli
    P T Lomedico
    Nature 312:458-62. 1984
  7. ncbi Multifactorial induction of gene expression and nuclear localization of mouse interleukin 1 alpha
    L Burysek
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Cytokine 8:460-7. 1996
  8. pmc Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion
    R Horai
    Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108, Japan
    J Exp Med 187:1463-75. 1998
  9. ncbi Identification and initial characterization of four novel members of the interleukin-1 family
    S Kumar
    Department of Bone and Cartilage Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Biol Chem 275:10308-14. 2000
  10. ncbi Protective role of interleukin-1 in mycobacterial infection in IL-1 alpha/beta double-knockout mice
    H Yamada
    Department of Molecular Pathology, The Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, Kiyose, Tokyo
    Lab Invest 80:759-67. 2000

Scientific Experts

Detail Information

Publications119 found, 100 shown here

  1. ncbi Biologic basis for interleukin-1 in disease
    C A Dinarello
    Department of Medicine, Tufts University, Boston, MA USA
    Blood 87:2095-147. 1996
    ..At the end of each section, a short commentary summarizes what the author considers established or controversial topics linking the biology of IL-1 to mechanisms of disease...
  2. pmc Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β
    Amir S Yazdi
    Department of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    Proc Natl Acad Sci U S A 107:19449-54. 2010
    ..The current use of nano-TiO(2) may present a health hazard due to its capacity to induce IL-1R signaling, a situation reminiscent of inflammation provoked by asbestos exposure...
  3. pmc Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators
    D Caput
    Proc Natl Acad Sci U S A 83:1670-4. 1986
    ..It is particularly prevalent among mRNAs encoding proteins related to the inflammatory response...
  4. doi Sialylation of 3-methylcholanthrene-induced fibrosarcoma determines antitumor immune responses during immunoediting
    Merav Cohen
    Department of Biotechnology Engineering, Faculty of Engineering, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Immunol 185:5869-78. 2010
    ..When immunoediting is impaired, such as in IFN-γ(-/-) and IL-1α(-/-) mice, the overt tumor consists of desialylayed tumor cells that interact better with immunosurveillance cells...
  5. ncbi Interleukin-1 alpha and beta genes: linkage on chromosome 2 in the mouse
    P D'Eustachio
    Department of Biochemistry, New York University Medical Center, NY 10016
    Immunogenetics 26:339-43. 1987
    ..7 centimorgans distal to B2m (beta-2 microglobulin). We have named the locus encoding IL-1 alpha Il-1 alpha and the locus encoding IL-1 beta Il-1b...
  6. ncbi Cloning and expression of murine interleukin-1 cDNA in Escherichia coli
    P T Lomedico
    Nature 312:458-62. 1984
    ..The IL-1 cDNA codes for a polypeptide precursor of 270 amino acids. Biologically active IL-1 was produced in E. coli by expressing the carboxy-terminal 156 amino acids of the IL-1 precursor...
  7. ncbi Multifactorial induction of gene expression and nuclear localization of mouse interleukin 1 alpha
    L Burysek
    Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Cytokine 8:460-7. 1996
    ..The rapid responses of IL-1A gene expression to multifactorial stimulation and pronounced nuclear localization of IL-1 alpha proteins further support the existence of a hypothetical nuclear function of IL-1 alpha...
  8. pmc Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion
    R Horai
    Laboratory Animal Research Center, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108, Japan
    J Exp Med 187:1463-75. 1998
    ..The importance of IL-1ra both in normal physiology and under stress is also suggested...
  9. ncbi Identification and initial characterization of four novel members of the interleukin-1 family
    S Kumar
    Department of Bone and Cartilage Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Biol Chem 275:10308-14. 2000
    ..This suggests that IL-1H1 may be involved in pathogenesis of immune mediated disease processes. The addition of four novel IL-1 homologues suggests that the IL-1 family is significantly larger than previously thought...
  10. ncbi Protective role of interleukin-1 in mycobacterial infection in IL-1 alpha/beta double-knockout mice
    H Yamada
    Department of Molecular Pathology, The Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, Kiyose, Tokyo
    Lab Invest 80:759-67. 2000
    ..Our data clearly indicate that IL-1 is important for the generation of early-phase protective immunity against mycobacterial infection...
  11. ncbi Role of IL-1alpha and IL-1beta in ischemic brain damage
    H Boutin
    School of Biological Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Neurosci 21:5528-34. 2001
    ....
  12. ncbi Suppression of autoimmune arthritis in interleukin-1-deficient mice in which T cell activation is impaired due to low levels of CD40 ligand and OX40 expression on T cells
    Shinobu Saijo
    Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Arthritis Rheum 46:533-44. 2002
    ....
  13. pmc Interleukin-1 beta, but not interleukin-1 alpha, is required for T-cell-dependent antibody production
    S Nakae
    Centre for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Immunology 104:402-9. 2001
    ..These results show that endogenous IL-1 beta, but not IL-1 alpha, is involved in T-cell-dependent antibody production, and IL-1 promotes the antigen-specific T-cell helper function through the T-cell-APC interaction...
  14. ncbi Reduced postischemic apoptosis in the hippocampus of mice deficient in interleukin-1
    Hidekatsu Mizushima
    Department of Anatomy, Showa University School of Medicine, Shinagawa ku, Tokyo 142 8555, Japan
    J Comp Neurol 448:203-16. 2002
    ..These observations strongly suggest that endogenous IL-1 contributes to ischemic brain damage, and this influence may act through the release of nitric oxide by iNOS...
  15. ncbi IL-1 is required for allergen-specific Th2 cell activation and the development of airway hypersensitivity response
    Susumu Nakae
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Int Immunol 15:483-90. 2003
    ..These observations indicate that IL-1 plays important roles in the development of AHR...
  16. ncbi Intracellular interleukin-1alpha functionally interacts with histone acetyltransferase complexes
    Miroslava Buryskova
    Department of Pharmacology of Natural Products and Clinical Pharmacology, University of Ulm, D 89081 Ulm, Germany
    J Biol Chem 279:4017-26. 2004
    ..Our data provide the first solid evidence for the nuclear target of the IL-1alpha precursor and suggest its novel function in transcriptional control...
  17. ncbi Differential effects of IL-1 alpha and IL-1 beta on tumorigenicity patterns and invasiveness
    Xiaoping Song
    Department of Microbiology and Immunology, Faculty of Health Sciences, The Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Immunol 171:6448-56. 2003
    ....
  18. pmc Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice
    Hiroshi Hata
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, 53 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    J Clin Invest 114:582-8. 2004
    ..The results also indicate that targeting not only each cytokine but also each cell population secreting distinct cytokines could be an effective treatment of rheumatoid arthritis...
  19. ncbi Compensatory response of IL-1 gene knockout mice after pulmonary infection with Klebsiella pneumoniae
    Masaaki Tanabe
    Department of Microbiology, Omori Hospital, Toho University School of Medicine, 5 21 16 Omori nishi, Ota ku Tokyo, Japan
    J Med Microbiol 54:7-13. 2005
    ..The data suggest that compensatory production of TNF-alpha in IL-1 KO mice contributes to the host defence against K. pneumoniae infection...
  20. ncbi Abnormal T cell activation caused by the imbalance of the IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitis
    Taizo Matsuki
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Int Immunol 18:399-407. 2006
    ..These observations suggest that the IL-1/IL-1Ra system is crucial for auto-antigen-specific T cell induction and contributes to the development of EAE...
  21. ncbi IL-1beta, but not IL-1alpha, is required for antigen-specific T cell activation and the induction of local inflammation in the delayed-type hypersensitivity responses
    Aya Nambu
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Shirokanedai, Tokyo 108 8639, Japan
    Int Immunol 18:701-12. 2006
    ..In addition, CD4+ T cell-derived IL-1 plays an important role in the activation of DCs during the elicitation phase, resulting in the production of TNF, that activate allergen-specific T cells...
  22. ncbi Differential role and tissue specificity of interleukin-1alpha gene expression in atherogenesis and lipid metabolism
    Yehuda Kamari
    Institute of Lipid and Atherosclerosis Research, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Tel Hashomer 52621, Israel
    Atherosclerosis 195:31-8. 2007
    ..We examined the role of IL-1alpha and IL-1beta expressed by bone marrow-derived cells in atherogenesis and lipid metabolism...
  23. pmc Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury
    Luis A Ortiz
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 104:11002-7. 2007
    ..Identification of IL1RN-expressing human MSC subpopulations may provide a novel cellular vector for treating chronic inflammatory diseases in humans...
  24. ncbi Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells
    Astrid J van Beelen
    Department of Cell Biology and Histology, Academic Medical Centre of the University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Immunity 27:660-9. 2007
    ..Thus, antibacterial Th17-mediated immunity in humans is orchestrated by DCs upon sensing bacterial NOD2-ligand MDP...
  25. ncbi Inflammasome-mediated production of IL-1beta is required for neutrophil recruitment against Staphylococcus aureus in vivo
    Lloyd S Miller
    Division of Dermatology, University of California, Los Angeles, CA 90095, USA
    J Immunol 179:6933-42. 2007
    ..aureus in vivo...
  26. pmc Intracellular interleukin-1alpha mediates interleukin-8 production induced by Chlamydia trachomatis infection via a mechanism independent of type I interleukin-1 receptor
    Wen Cheng
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Infect Immun 76:942-51. 2008
    ..Thus, we have identified a novel mechanism for chlamydial induction of the chemokine IL-8...
  27. pmc Tumorigenicity of IL-1alpha- and IL-1beta-deficient fibrosarcoma cells
    Irina Nazarenko
    Department of Tumor Progression and Tumor Defense, German Cancer Research Center, Heidelberg, Germany
    Neoplasia 10:549-62. 2008
    ..Both sarcoma cell-derived IL-1alpha and IL-1beta promote tumor growth. However, IL-1alpha exerts regulatory activity on the tumor cell-matrix cross-talk, and only IL-1beta initiates systemic inflammation...
  28. pmc Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis
    Toshiharu Sakurai
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Cancer Cell 14:156-65. 2008
    ..IL-1 alpha release by necrotic hepatocytes is therefore an important mediator of liver tumorigenesis...
  29. pmc The dynamics and mechanisms of interleukin-1alpha and beta nuclear import
    Nadia M Luheshi
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, UK
    Traffic 10:16-25. 2009
    ..These data provide valuable insights into the dynamic regulation of intracellular cytokine trafficking...
  30. pmc Cutting edge: critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1 alpha released from dying cells
    Tatjana Eigenbrod
    Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 181:8194-8. 2008
    ..These studies show that IL-1alpha is a key danger signal released from necrotic cells to trigger CXCL1 secretion and recruitment of neutrophils via IL-1R/MyD88 on neighboring mesothelial cells...
  31. doi Host-derived interleukin-1alpha is important in determining the immunogenicity of 3-methylcholantrene tumor cells
    Moshe Elkabets
    The Shraga Segal Department of Microbiology and Immunology and Faculty of Health Sciences and The Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Immunol 182:4874-81. 2009
    ..Elucidation of the involvement of the IL-1 molecules in the malignant process will hopefully lead to the development of novel approaches for chemoprevention and immunotherapy...
  32. pmc Nuclear retention of IL-1 alpha by necrotic cells: a mechanism to dampen sterile inflammation
    Nadia M Luheshi
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, UK
    Eur J Immunol 39:2973-80. 2009
    ..The remaining IL-1 alpha was immobilized in the nuclei of the dead cells. Thus, nuclear retention of IL-1 alpha may serve to limit inflammation following cell death...
  33. doi Vascular smooth muscle cell apoptosis induces interleukin-1-directed inflammation: effects of hyperlipidemia-mediated inhibition of phagocytosis
    Murray C H Clarke
    Division of Cardiovascular Medicine, University of Cambridge, Box 110, ACCI, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    Circ Res 106:363-72. 2010
    ....
  34. pmc Differential release of chromatin-bound IL-1alpha discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation
    Idan Cohen
    The Shraga Segal Department of Microbiology and Immunology and Faculty of Health Sciences and Cancer Research Center, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Proc Natl Acad Sci U S A 107:2574-9. 2010
    ..Tissues surrounding the necrotic site also sustain damage from the myeloid cells. Nuclear trafficking and differential release during necrosis vs. apoptosis demonstrate that inflammation by IL-1alpha is tightly controlled...
  35. doi Platelet interleukin-1alpha drives cerebrovascular inflammation
    Peter Thornton
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Blood 115:3632-9. 2010
    ....
  36. pmc Identification of the cellular sensor that stimulates the inflammatory response to sterile cell death
    Hajime Kono
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 184:4470-8. 2010
    ..One key way they accomplish this important task is by producing IL-1alpha that is needed to initiate the inflammatory response...
  37. pmc NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
    Peter Duewell
    Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 464:1357-61. 2010
    ..These findings provide new insights into the pathogenesis of atherosclerosis and indicate new potential molecular targets for the therapy of this disease...
  38. doi IL-1α and IL-1β recruit different myeloid cells and promote different stages of sterile inflammation
    Peleg Rider
    The Shraga Segal Department of Microbiology and Immunology and The Cancer Research Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    J Immunol 187:4835-43. 2011
    ..Overall, our data provide new insight into the biology of IL-1 molecules as well as on the regulation of sterile inflammation...
  39. pmc Inflammasome activation and IL-1β target IL-1α for secretion as opposed to surface expression
    Antonia Fettelschoss
    Department of Dermatology, Zurich University Hospital, 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 108:18055-60. 2011
    ..We further demonstrate that IL-1β directly binds IL-1α, thus identifying IL-1β as a shuttle for another proinflammatory cytokine. These results have direct impact on selective treatment modalities of inflammatory diseases...
  40. pmc IL-1α/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice
    Fernando M Botelho
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, Canada
    PLoS ONE 6:e28457. 2011
    ..Despite this, the cellular and molecular mechanisms that contribute to COPD pathogenesis are still poorly understood...
  41. pmc Interleukin-1α expression precedes IL-1β after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues
    Nadia M Luheshi
    University of Manchester, UK
    J Neuroinflammation 8:186. 2011
    ..In order to determine this we investigated the temporal and spatial profiles of IL-1α and IL-1β expression after cerebral ischemia...
  42. doi Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1
    Olaf Gross
    Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
    Immunity 36:388-400. 2012
    ..Because inflammasomes contribute to the pathology of numerous chronic inflammatory diseases such as gout and diabetes, IL-1α antagonists may be beneficial in the treatment of these disorders...
  43. pmc Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1α, controlling necrosis-induced sterile inflammation
    Yue Zheng
    Division of Cardiovascular Medicine, Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Immunity 38:285-95. 2013
    ..Thus, we report a cell type-dependent process that fundamentally governs IL-1α activity postnecrosis and the mechanism allowing conditional release of this blockade...
  44. pmc IL-1α signaling initiates the inflammatory response to virulent Legionella pneumophila in vivo
    Kevin C Barry
    Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    J Immunol 190:6329-39. 2013
    ..Our results establish IL-1α as a critical initiator of the inflammatory response to L. pneumophila in vivo and point to an important role for IL-1α in providing an alternative to inflammasome-mediated immune responses in vivo...
  45. pmc RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3
    John R Lukens
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nature 498:224-7. 2013
    ....
  46. ncbi IL-1alpha stimulation of osteoclast survival through the PI 3-kinase/Akt and ERK pathways
    Zang Hee Lee
    National Research Laboratory for Bone Metabolism, Research Center for Proteineous Materials, and School of Dentistry, Chosun University, Gwangju, Korea
    J Biochem 131:161-6. 2002
    ..These findings implicate the PI 3-kinase/Akt and ERK signaling pathways in the promotion of osteoclast survival by IL-1alpha...
  47. pmc Antiviral and immunoregulatory activities of IFN-gamma depend on constitutively expressed IL-1alpha
    Vladimir Hurgin
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 104:5044-9. 2007
    ..Furthermore, IFN-gamma induced serum IL-18 binding protein in wild-type mice but not in IL-1alpha/beta double-deficient mice. Thus, constitutively expressed IL-1alpha is critical for numerous IFN-gamma activities...
  48. ncbi Detection of interleukin-1, interleukin-6, and tumor necrosis factor-alpha in the uterus during the second half of pregnancy in the mouse
    M De
    Department of Pathology and Oncology, University of Kansas Medical Center, Kansas City 66103
    Endocrinology 131:14-20. 1992
    ..Those data showing the kinetics of cytokine production during fetal development raise the possibility that cytokines and cytokine-induced mediators modulate cellular events during the late stages of pregnancy in the mouse...
  49. ncbi Mouse IL-1 receptor antagonist protein. Molecular characterization, gene mapping, and expression of mRNA in vitro and in vivo
    K Zahedi
    Division of Immunology, Children s Hospital, Boston, MA 02115
    J Immunol 146:4228-33. 1991
    ..mouse Il 1rn gene was mapped to the proximal region of chromosome 2 between the centromere and Spna2; the other known members of the mouse IL-1 gene family, Il 1a and Il 1b, both map to the same chromosome, although not in close linkage.
  50. ncbi The IL-1 alpha and beta genes are closely linked (less than 70 kb) on mouse chromosome 2
    A R Silver
    Division of Radiation Oncogenesis, MRC Radiobiology Unit, Chilton, Didcot, Oxon, U K
    Somat Cell Mol Genet 16:549-56. 1990
    ..The apparent clustering of such hemopoietic genes is discussed in relation to evolutionary tandem gene duplication and possible associations with chromosomal fragile sites and leukemogenesis...
  51. ncbi Diurnal variation of heart rate, locomotor activity, and body temperature in interleukin-1 alpha/beta doubly deficient mice
    Masashi Furuzawa
    Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Exp Anim 51:49-56. 2002
    ..These results suggest that IL-1 may play important physiological and pathophysiological roles on biobehavioral activities...
  52. pmc Interleukin gene expression in mouse preimplantation development
    N Gerwin
    Center for Blood Research, Inc, Boston, MA 02115, USA
    Dev Immunol 4:169-79. 1995
    ..The controlled expression of these "inflammatory-type" cytokines and their receptors suggests a role for these growth factors during the early phases of mouse ontogeny...
  53. ncbi Lack of antigen-specific tissue remodeling in mice deficient in the macrophage galactose-type calcium-type lectin 1/CD301a
    Kayoko Sato
    Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Blood 106:207-15. 2005
    ..were not myeloid or lymphoid lineage cells and the number significantly declined after administration of interleukin 1 alpha (IL-1alpha) into the pouch of MGL1-deficient mice...
  54. doi Opposite effects of interleukin-1alpha and transforming growth factor-beta2 induce stage-specific regulation of junctional adhesion molecule-B gene in Sertoli cells
    Yang Wang
    Division of Endocrinology, School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong
    Endocrinology 150:2404-12. 2009
    ..This study shows for the first time that IL-1alpha and TGF-beta2 regulate JAM-B expression in an opposite manner, and in vitro data obtained herein provide some clues on how junctions are regulated in the testis...
  55. ncbi Effects of endostatin production on oncogenicity and metastatic activity of HPV16-transformed mouse cells: role of interleukin 1alpha
    Monika Lakatosova-Andelova
    Department of Experimental Virology, Institute of Haematology and Blood Transfusion, Prague 2, Czech Republic
    Int J Oncol 35:213-22. 2009
    ..Additional experiments indicated that the suppression of the production of IL-1alpha by the parental MK16 caused by endostatin was due to an autocrine mechanism...
  56. doi IL-1alpha and IL-1beta have different effects on formation and activity of large osteoclasts
    Diana P Trebec-Reynolds
    Department of Biochemistry, University of Toronto, Toronto, ON, Canada
    J Cell Biochem 109:975-82. 2010
    ..These results demonstrate that IL-1 predominantly affects large OCs. The dissimilarity of responses to IL-1alpha and IL-1beta suggests that these isoforms activate different signaling pathways within the two OC populations...
  57. doi Deficiency of interleukin-1 receptor antagonist induces aortic valve disease in BALB/c mice
    Kikuo Isoda
    Internal Medicine I, National Defense Medical College, 3 2, Namiki, Tokorozawa, Saitama, 359 8513, Japan
    Arterioscler Thromb Vasc Biol 30:708-15. 2010
    ..However, the role of IL-1Ra in aortic valve stenosis (AS) remains poorly understood [corrected]...
  58. pmc Role of IL-1α in cisplatin-induced acute renal failure in mice
    Jay Wook Lee
    Department of Internal Medicine, Chung Ang University College of Medicine, Seoul, Korea
    Korean J Intern Med 26:187-94. 2011
    ..We thus asked whether IL-1α deficiency underlies the mechanism of protection against cisplatin-induced ARF in these mice...
  59. doi Knockdown of interleukin-1α does not attenuate LPS-induced production of interleukin-1β in mouse macrophages
    Tal Almog
    The Bert W Strassburger Lipid Center, Sheba Medical Center, Tel Hashomer, Israel
    Cytokine 73:138-43. 2015
    ..Rather, they suggest that IL-1α acts mainly as an alarmin that is sequestered in the nucleus following stimulation with TLR-4...
  60. doi Secreted IL-1α promotes T-cell activation and expansion of CD11b(+) Gr1(+) cells in carbon tetrachloride-induced liver injury in mice
    Dandan Lin
    Laboratory of Cellular and Molecular Tumor Immunology, Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, Jiangsu, China
    Eur J Immunol 45:2084-98. 2015
    ..The controlled release of IL-1α could be a critical regulator during acute liver inflammation...
  61. pmc Interleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury
    Atsushi Sato
    Department of Anatomy, Showa University School of Medicine, 15 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Neuroinflammation 9:65. 2012
    ..Moreover, we demonstrated the contribution of IL-1 to both the classical and alternative activation of MG in vitro using an adult MG primary culture...
  62. doi Autophagy regulates IL-23 secretion and innate T cell responses through effects on IL-1 secretion
    Celia Peral de Castro
    Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin 2, Ireland
    J Immunol 189:4144-53. 2012
    ..These data demonstrate that autophagy has a potentially pivotal role to play in the induction and regulation of inflammatory responses by innate immune cells, largely driven by IL-1 and its consequential effects on IL-23 secretion...
  63. pmc Distinctive cytokines as biomarkers predicting fatal outcome of severe Staphylococcus aureus bacteremia in mice
    Sanne van den Berg
    Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Centre, Rotterdam, The Netherlands
    PLoS ONE 8:e59107. 2013
    ..KC was a biomarker elevated irrespective the progression of infection, which is very interesting regarding clinical application in view of the heterogeneity of patients experiencing bacteraemia in this respect...
  64. ncbi Analysis of mouse Evx genes: Evx-1 displays graded expression in the primitive streak
    M K Dush
    Department of Anatomy and Developmental Biology Program, School of Medicine, University of California, San Francisco 94143
    Dev Biol 151:273-87. 1992
    ....
  65. ncbi Characterization of mouse thrombospondin 2 sequence and expression during cell growth and development
    C D Laherty
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109
    J Biol Chem 267:3274-81. 1992
    ..Additionally, the TSP genes (Thbs1 and Thbs2) were mapped to single loci on mouse chromosomes 2 and 17, respectively...
  66. pmc Interleukin 1 or tumor necrosis factor can promote Coxsackie B3-induced myocarditis in resistant B10.A mice
    J R Lane
    Department of Immunology and Infectious Diseases, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205
    J Exp Med 175:1123-9. 1992
    ..Treatment with IL-1 or TNF alone promoted CB3-induced autoimmune myocarditis in resistant B10.A mice. Myocarditis was also observed when uninfected mice were immunized with syngeneic heart extract in the presence of IL-1 or TNF...
  67. ncbi A molecular genetic linkage map of mouse chromosome 2
    L D Siracusa
    Mammalian Genetics Laboratory, NCI Frederick Cancer Research Facility, Maryland 21701
    Genomics 6:491-504. 1990
    ..Comparisons between the mouse and the human genomes indicate that mouse chromosome 2 contains regions homologous to at least six human chromosomes. Mouse models for human diseases are discussed...
  68. pmc Recombinant inbred strain and interspecific backcross analysis of molecular markers flanking the murine agouti coat color locus
    L D Siracusa
    Mammalian Genetics Laboratory, NCI Frederick Cancer Research Facility, Maryland 21701
    Genetics 122:669-79. 1989
    ..The Psp-2 locus maps to mouse chromosome 14. The Hck-2 locus maps near the centromere of mouse chromosome 4 and may identify the Lyn locus. The Hck-3 locus maps near the distal end of mouse chromosome 4 and may identify the Lck locus...
  69. ncbi Identification of a sequence-specific single-stranded DNA binding protein that suppresses transcription of the mouse myelin basic protein gene
    S Haas
    Jefferson Institute of Molecular Medicine, Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 270:12503-10. 1995
    ..The myef-2 gene maps to mouse chromosome 2. The relevance of these findings for regulation of MBP gene expression and oligodendrocyte differentiation is discussed...
  70. ncbi The tight skin (Tsk) mutation in the mouse, a model for human fibrotic diseases, is tightly linked to the beta 2-microglobulin (B2m) gene on chromosome 2
    L D Siracusa
    Department of Microbiology and Immunology, Jefferson Cancer Institute, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 5541
    Genomics 17:748-51. 1993
    ..Our results refine the location of Tsk to a 3-cM region, eliminate several genes from consideration as the Tsk mutation, identify molecular probes tightly linked with Tsk, and suggest candidate genes responsible for the Tsk phenotype...
  71. ncbi Tight-skin (Tsk) maps on mouse chromosome 2 within the region of linkage homology with human chromosome 15
    R C Doute
    DVA Medical Center, Newington, Connecticut 06111
    Genomics 22:223-5. 1994
    ..To facilitate the positional cloning of Tsk, an interspecific backcross between C57BL/6J Tsk/+ and Mus spretus has been conducted. Our data link Tsk to cloned genetic markers and indicate the order pa-B2m-Tsk-Fbn-1-II-1a-a...
  72. ncbi Signal transduction pathway(s) involved in phorbol ester and autocrine induction of interleukin-1 alpha mRNA in murine keratinocytes
    W Y Lee
    Department of Pharmacology Toxicology, College of Pharmacy, University of Texas, Austin 78712
    J Biol Chem 269:17971-80. 1994
    ..This study suggests that the activation of AP-1 may be a common event through which TPA and IL-1 alpha induce IL-1 alpha mRNA...
  73. ncbi Cytokines in the central nervous system: expression of macrophage colony stimulating factor and its receptor during development
    Y Chang
    Department of Pathology, Columbia University College of Physicians and Surgeons, New York, NY 10032
    J Neuroimmunol 52:9-17. 1994
    ....
  74. ncbi Treatment of mice with IL-1 before infection increases resistance to a lethal challenge with Salmonella typhimurium. The effect correlates with the resistance allele at the Ity locus
    P J Morrissey
    Immunex Corporation, Seattle, WA 98101
    J Immunol 153:212-9. 1994
    ..Thus, IL-1 alpha pretreatment enhances the resistance of Ityr, but not Itys strains of mice to a lethal challenge with S. typhimurium by up-regulating antibacterial mechanisms shortly after infection...
  75. ncbi Temporal and spatial immunolocalization of cytokines in murine chronic granulomatous tissue. Implications for their role in tissue development and repair processes
    I Appleton
    Department of Experimental Pathology, William Harvey Research Institute, St Bartholomew s Hospital Medical College, London, United Kingdom
    Lab Invest 69:405-14. 1993
    ....
  76. pmc Amelioration of established murine collagen-induced arthritis with anti-IL-1 treatment
    W B van den Berg
    Department of Rheumatology, University Hospital Nijmegen, The Netherlands
    Clin Exp Immunol 95:237-43. 1994
    ..It is concluded that IL-1 is an important determinant in both inflammation and cartilage destruction in collagen arthritis, and this may have implications for therapy in human arthritis...
  77. pmc Delimiting the location of the scrapie prion incubation time gene on chromosome 2 of the mouse
    G A Carlson
    McLaughlin Research Institute, Great Falls, Montana 59401
    Genetics 133:979-88. 1993
    ..Thus, Prn-pb transgenes and Prn-i may modulate scrapie pathogenesis by different mechanisms...
  78. ncbi Tumor necrosis factor-alpha and interleukin-1 alpha expression in a murine model of allergic bronchopulmonary aspergillosis
    H W Chu
    Unite de Recherche, Hopital Laval, Universite Laval, Ste Foy, Quebec, Canada
    Lab Anim Sci 46:42-7. 1996
    ..fumigatus induced inflammatory process and that upregulated intercellular adhesion molecule-1 expression may represent one of the roles played by TNF-alpha and IL-1 alpha in this murine model...
  79. ncbi Interleukin-1 alpha (IL-1 alpha) and tumor necrosis factor alpha (TNF alpha) regulate insulin-like growth factor binding protein-1 (IGFBP-1) levels and mRNA abundance in vivo and in vitro
    C A Benbassat
    Department of Surgery, Cornell University Medical College, New York, USA
    Horm Metab Res 31:209-15. 1999
    ..Additional studies are required to identify specific mechanisms mediating effects of cytokines on hepatic production of IGFBP-1...
  80. ncbi Expression of pro-inflammatory cytokines in mouse blastocysts during implantation: modulation by steroid hormones
    Sayantani Basak
    Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi
    Am J Reprod Immunol 47:2-11. 2002
    ..The present study is aimed at analysing the expression and hormonal modulation of two pro-inflammatory cytokines [interleukin-1alpha (IL-1alpha) and IL-6] in mouse blastocysts during implantation...
  81. ncbi Involvement of tumor necrosis factor alpha, rather than interleukin-1alpha/beta or nitric oxides in the heme oxygenase-1 gene expression by lipopolysaccharide in the mouse liver
    Takiko Oguro
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, 142 8555, Tokyo, Japan
    FEBS Lett 516:63-6. 2002
    ..All of these findings indicate that TNFalpha is a major candidate to trigger HO-1 induction in response to LPS stimulation, and that its message is likely transduced through JNK and p38 pathways...
  82. ncbi Involvement of intratesticular IL-1 system in the regulation of Sertoli cell functions
    Mahmoud Huleihel
    Department of Microbiology and Immunology, Soroka University Medical Center and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Mol Cell Endocrinol 187:125-32. 2002
    ....
  83. ncbi Genomic organization of the interleukin-1 locus
    Scott L Taylor
    Immunex Corporation, 51 University Street, Seattle, Washington 98101, USA
    Genomics 79:726-33. 2002
    ..There is a break in the mouse locus of > 100 kb, compared with the human locus, located between Il1b and the most centromere-proximal of the novel mouse genes. The mouse seems to be missing an ortholog of human IL1F7...
  84. ncbi Alterations in cytokine regulation in aged epidermis: implications for permeability barrier homeostasis and inflammation. I. IL-1 gene family
    J Ye
    Department of Dermatology, University of California at San Francisco, CA USA
    Exp Dermatol 11:209-16. 2002
    ..Together, these results show that selective alterations in the IL-1 family of cytokines occur with aging and that defects in IL-1 signaling may contribute to the epidermal permeability barrier abnormality of aged skin...
  85. ncbi Long-term modulation of glucose utilization by IL-1 alpha and TNF-alpha in astrocytes: Na+ pump activity as a potential target via distinct signaling mechanisms
    Céline Véga
    Institut de Physiologie, Lausanne, Switzerland
    Glia 39:10-8. 2002
    ..These data suggest that Na(+) pump activity is a common target for both the long-term metabolic action of cytokines promoted by the activation of distinct signaling pathways and the enhanced metabolic response to glutamate...
  86. pmc IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions
    Hiroshi Konishi
    Department of Dermatology, Mie University School of Medicine, Tsu 514 8507, Japan
    Proc Natl Acad Sci U S A 99:11340-5. 2002
    ..Our present study might provide insight into understanding the pathogenesis of and establishing therapeutics for chronic inflammatory skin diseases including AD...
  87. pmc IL-1 plays an important role in lipid metabolism by regulating insulin levels under physiological conditions
    Taizo Matsuki
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Exp Med 198:877-88. 2003
    ..These observations suggest that IL-1 plays an important role in lipid metabolism by regulating insulin levels and lipase activity under physiological conditions...
  88. ncbi Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: critical role of myeloid differentiation factor 88
    Leo A B Joosten
    Rheumatology Research Laboratory and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Immunol 171:6145-53. 2003
    ..Since agonists of the Toll-like pathway are abundantly involved in both septic and rheumatoid arthritis, targeting of MyD88 may be a novel therapy in inflammatory joint diseases...
  89. pmc Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK
    Melina Fan
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 18:278-89. 2004
    ..The discovery of p160MBP as a PGC-1alpha regulator has important implications for the understanding of energy balance and diabetes...
  90. pmc Effects of PM10 in human peripheral blood monocytes and J774 macrophages
    D M Brown
    School of Life Sciences, Napier University, Edinburgh, UK
    Respir Res 5:29. 2004
    ..Impaired motility and phagocytic ability as shown by changes in the F-actin cytoskeleton is likely to play a key role in particle clearance from the lung...
  91. ncbi Stimulation of epidermal calcium gradient loss and increase in TNF-alpha and IL-1alpha expressions by glycolic acid in murine epidermis
    Se Kyoo Jeong
    BK21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
    Exp Dermatol 14:571-9. 2005
    ..An in vitro study using cultured keratinocytes suggested that glycolic acid could lower the calcium ion concentration, at least in part, through the chelating effects of the glycolic acid on the cationic ions...
  92. ncbi Endogenous interleukin (IL)-1 alpha and IL-1 beta are crucial for host defense against disseminated candidiasis
    Alieke G Vonk
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Infect Dis 193:1419-26. 2006
    ..It is, however, unknown whether they provide protection through similar mechanisms. We investigated the effect of endogenous IL-1 alpha and IL-1 beta on disseminated C. albicans infection...
  93. pmc Disruption of interleukin-18, but not interleukin-1, increases vulnerability to preterm delivery and fetal mortality after intrauterine inflammation
    Xiaoyang Wang
    Perinatal Center, Department of Physiology, Goteborg University, Box 432, S 405 30 Goteborg, Sweden, and The Third Affiliated Hospital of Zhengzhou University, People s Republic of China
    Am J Pathol 169:967-76. 2006
    ....
  94. pmc T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis
    Keiji Hirota
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    J Exp Med 204:41-7. 2007
    ..Extrinsic or intrinsic stimuli further expand these cells, thereby triggering autoimmune disease. Intervention in these events at cellular and molecular levels is useful to treat and prevent autoimmune disease, in particular RA...
  95. pmc Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1
    Peter A Nigrovic
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:2325-30. 2007
    ..These findings illuminate a mechanism by which mast cells can participate in the pathogenesis of autoimmune inflammatory arthritis and provide insights of potential relevance to human rheumatoid arthritis...
  96. ncbi Intestinal inflammation downregulates smooth muscle CPI-17 through induction of TNF-alpha and causes motility disorders
    Takashi Ohama
    Dept of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The Univ of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    Am J Physiol Gastrointest Liver Physiol 292:G1429-38. 2007
    ..These findings suggest that CPI-17 was downregulated during intestinal inflammation and that TNF-alpha plays a central role in this process. Downregulation of CPI-17 may play a role in motility impairments in inflammation...
  97. ncbi Mast cells are crucial for early inflammation, migration of Langerhans cells, and CTL responses following topical application of TLR7 ligand in mice
    Valeska Heib
    Institute for Immunology, University of Mainz, Mainz, Germany
    Blood 110:946-53. 2007
    ..Thus, these findings demonstrate the potent versatility of alternatively activated mast cells at the interface of innate and adaptive immunity...
  98. pmc TNF-induced structural joint damage is mediated by IL-1
    Jochen Zwerina
    Department of Internal Medicine III, Medical University of Vienna, A 1090 Vienna, Austria
    Proc Natl Acad Sci U S A 104:11742-7. 2007
    ..These data show that TNF-mediated cartilage damage is completely and TNF-mediated bone damage is partially dependent on IL-1, suggesting that IL-1 is a crucial mediator for inflammatory cartilage and bone degradation...
  99. ncbi Peripheral TNFalpha, but not peripheral IL-1, requires endogenous IL-1 or TNFalpha induction in the brain for the febrile response
    Dai Chida
    Division of Cell Biology, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Biochem Biophys Res Commun 364:765-70. 2007
    ....
  100. pmc Overexpression of IL-1alpha in skin differentially modulates the immune response to scarification with vaccinia virus
    Tian Tian
    Department of Dermatology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Invest Dermatol 129:70-8. 2009
    ....
  101. doi IL-1alpha accelerates stratum corneum formation and improves permeability barrier homeostasis during murine fetal development
    Yan J Jiang
    Metabolism Section, Veterans Affairs Medical Center, and Departments of Dermatology and Medicine, University of California at San Francisco, United States
    J Dermatol Sci 54:88-98. 2009
    ..The ontogenesis of the epidermal permeability barrier is complex and incompletely understood. Previously we showed that IL-1 and TNFalpha regulate permeability barrier homeostasis in adult mice...

Research Grants2

  1. 2008 Biology of Acute Respiratory Infections Gordon Research Conference
    JOSEPH MIZGERD; Fiscal Year: 2007
    ..End of Abstract) [unreadable] [unreadable] [unreadable]..
  2. Gene expression networks for metabolic syndrome traits in mice
    Thomas A Drake; Fiscal Year: 2010
    ....