Il18

Summary

Gene Symbol: Il18
Description: interleukin 18
Alias: Igif, Il-18, interleukin-18, IFN-gamma-inducing factor, IL-1 gamma, interferon gamma-inducing factor, interleukin-1 gamma
Species: mouse

Top Publications

  1. pmc Memory phenotype CD8+ T cells with innate function selectively develop in the absence of active Itk
    Jianfang Hu
    Center for Molecular Immunology and Infectious Disease and Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    Eur J Immunol 37:2892-9. 2007
  2. ncbi Invariant NKT cells amplify the innate immune response to lipopolysaccharide
    Niranjana A Nagarajan
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    J Immunol 178:2706-13. 2007
  3. ncbi Restoration of natural IgM production from liver B cells by exogenous IL-18 improves the survival of burn-injured mice infected with Pseudomonas aeruginosa
    Manabu Kinoshita
    Division of Basic Traumatology, Research Institute, National Defense Medical College, Namiki 3 2, Tokorozawa 359 8513, Japan
    J Immunol 177:4627-35. 2006
  4. pmc Endogenous interleukin-18 is involved in immunity to Leishmania donovani but its absence does not adversely influence the therapeutic activity of sodium stibogluconate
    Alexander B Mullen
    Department of Pharmaceutical Sciences, University of Strathclyde, Glasgow, UK
    Immunology 119:348-54. 2006
  5. ncbi Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance
    Mihai G Netea
    Department of Internal Medicine and Nijmegen University Center for Infectious Diseases, Geert Grooteplein 8, 6500 HB, Nijmegen, The Netherlands
    Nat Med 12:650-6. 2006
  6. pmc Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo
    Katrin D Mayer-Barber
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:3326-30. 2010
  7. pmc A role for IL-18 in protective immunity against Mycobacterium tuberculosis
    Bianca E Schneider
    London School of Hygiene and Tropical Medicine, Infectious and Tropical Diseases Immunology, London, UK
    Eur J Immunol 40:396-405. 2010
  8. ncbi Cloning of a new cytokine that induces IFN-gamma production by T cells
    H Okamura
    Department of Bacteriology, Hyogo College of Medicine, Nishinomiya, Japan
    Nature 378:88-91. 1995
  9. ncbi IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells
    K Tominaga
    Third Department of Internal Medicine, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya 663 8501, Japan
    Int Immunol 12:151-60. 2000
  10. pmc Interleukin-18 impairs the pulmonary host response to Pseudomonas aeruginosa
    Marc J Schultz
    Laboratory of Experimental Internal Medicine, Department of Intensive Care Medicine, C3 326, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Infect Immun 71:1630-4. 2003

Detail Information

Publications138 found, 100 shown here

  1. pmc Memory phenotype CD8+ T cells with innate function selectively develop in the absence of active Itk
    Jianfang Hu
    Center for Molecular Immunology and Infectious Disease and Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    Eur J Immunol 37:2892-9. 2007
    ..These results indicate that active signals from Tec kinases regulate the development of memory-like CD8(+) T cells with innate function...
  2. ncbi Invariant NKT cells amplify the innate immune response to lipopolysaccharide
    Niranjana A Nagarajan
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    J Immunol 178:2706-13. 2007
    ....
  3. ncbi Restoration of natural IgM production from liver B cells by exogenous IL-18 improves the survival of burn-injured mice infected with Pseudomonas aeruginosa
    Manabu Kinoshita
    Division of Basic Traumatology, Research Institute, National Defense Medical College, Namiki 3 2, Tokorozawa 359 8513, Japan
    J Immunol 177:4627-35. 2006
    ..IL-18 treatment for the burned mice and their resultant natural IgM production were thus found to strengthen the host defense against P. aeruginosa infection...
  4. pmc Endogenous interleukin-18 is involved in immunity to Leishmania donovani but its absence does not adversely influence the therapeutic activity of sodium stibogluconate
    Alexander B Mullen
    Department of Pharmaceutical Sciences, University of Strathclyde, Glasgow, UK
    Immunology 119:348-54. 2006
    ....
  5. ncbi Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance
    Mihai G Netea
    Department of Internal Medicine and Nijmegen University Center for Infectious Diseases, Geert Grooteplein 8, 6500 HB, Nijmegen, The Netherlands
    Nat Med 12:650-6. 2006
    ..Obesity of Il18-/- mice resulted from accumulation of fat tissue based on increased food intake...
  6. pmc Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo
    Katrin D Mayer-Barber
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:3326-30. 2010
    ..Together our findings reveal a major role for IL-1beta in host resistance to M. tuberculosis and indicate that during this infection the cytokine can be generated by a mechanism that does not require TLR signaling or caspase-1...
  7. pmc A role for IL-18 in protective immunity against Mycobacterium tuberculosis
    Bianca E Schneider
    London School of Hygiene and Tropical Medicine, Infectious and Tropical Diseases Immunology, London, UK
    Eur J Immunol 40:396-405. 2010
    ..Thus, IL-18 plays a decisive role in protective immunity against tuberculosis...
  8. ncbi Cloning of a new cytokine that induces IFN-gamma production by T cells
    H Okamura
    Department of Bacteriology, Hyogo College of Medicine, Nishinomiya, Japan
    Nature 378:88-91. 1995
    ..Here we report the cloning of a recently identified IFN-gamma-inducing factor (IGIF) that augments natural killer (NK) activity in spleen cells...
  9. ncbi IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells
    K Tominaga
    Third Department of Internal Medicine, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya 663 8501, Japan
    Int Immunol 12:151-60. 2000
    ..We also show that T(h)1 cells but not T(h)2 cells have increased expression of IL-18R and IL-1R, and produce IFN-gamma in response to IL-18 and/or IL-1beta...
  10. pmc Interleukin-18 impairs the pulmonary host response to Pseudomonas aeruginosa
    Marc J Schultz
    Laboratory of Experimental Internal Medicine, Department of Intensive Care Medicine, C3 326, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Infect Immun 71:1630-4. 2003
    ..These results demonstrate that the presence of endogenous IL-18 activity facilitates inflammatory responses in the lung during Pseudomonas pneumonia, concurrently impairing bacterial clearance...
  11. ncbi IL-18 is a potent coinducer of IL-13 in NK and T cells: a new potential role for IL-18 in modulating the immune response
    T Hoshino
    Laboratory of Experimental Immunology, Division of Basic Sciences, National Cancer Institute, Frederick Cancer and Research Development Center, MD 21702, USA
    J Immunol 162:5070-7. 1999
    ..Thus, depending upon the cell type, IL-18 may act as a strong coinducer of Th1 or Th2 cytokines. Our findings suggest that IL-12 and IL-18 have different roles in the regulation of gene expression in NK and T cells...
  12. ncbi Induction of interferon-gamma inducing factor in the adrenal cortex
    B Conti
    Laboratory of Molecular Neurobiology, Cornell University Medical College at the W M Burke Medical Research Institute, White Plains, New York 10605, USA
    J Biol Chem 272:2035-7. 1997
    Interferon-gamma inducing factor (IGIF) is a recently identified cytokine also called interleukin-1gamma (IL-1gamma) or interleukin-18 (IL-18)...
  13. ncbi Interleukin 18, a cytokine which resembles IL-1 structurally and IL-12 functionally but exerts its effect independently of both
    K Kohno
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, Okayama, Japan
    Clin Immunol Immunopathol 86:11-5. 1998
  14. ncbi Evidence of IL-18 as a novel angiogenic mediator
    C C Park
    Department of Medicine, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
    J Immunol 167:1644-53. 2001
    ..05). These findings support a novel function for IL-18 as an angiogenic factor in RA and may elucidate a potential therapeutic target for angiogenesis-directed diseases...
  15. ncbi Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice
    Ekihiro Seki
    First Department of Surgery and Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Japan
    J Immunol 169:3863-8. 2002
    ..These results indicated a critical role for TLRs/MyD88-dependent IL-12/TNF-alpha production and for IL-12- and IL-18-mediated IFN-gamma production in early phase clearance of LM...
  16. pmc Host-derived interleukin-18 differentially impacts regulatory and conventional T cell expansion during acute graft-versus-host disease
    Robert Zeiser
    Division of Blood and Marrow Transplantation, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Biol Blood Marrow Transplant 13:1427-38. 2007
    ..We conclude that host-derived IL-18 is a major factor for IFN-gamma production that may have a protective effect on CD4(+)-mediated aGVHD, but is nonessential for Treg expansion in an allogeneic environment...
  17. ncbi Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein
    S Ushio
    Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, Okayama, Japan
    J Immunol 156:4274-9. 1996
    We have recently reported that a novel molecule, murine IFN-gamma-inducing factor (IGIF) produced by mouse liver cells, possesses potent biologic activities, including the induction of IFN-gamma production by spleen cells and the ..
  18. ncbi Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production
    M J Micallef
    Fujisaki Institute, Hayashibara Biochemical Laboratories Inc, Okayama, Japan
    Eur J Immunol 26:1647-51. 1996
    The novel cytokine interferon-gamma-inducing factor (IGIF) augments natural killer (NK) cell activity in cultures of human peripheral blood mononuclear cells (PBMC), similarly to the structurally unrelated cytokine interleukin (IL)-12...
  19. ncbi IFN-gamma-inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones
    H Tsutsui
    Section of Immunology, Toneyama Institute for Tuberculosis Research, Osaka, Japan
    J Immunol 157:3967-73. 1996
    ..Taken together, these findings suggest that hepatic NK cells participate in the immune response as effector cells through the Fas-FasL system in collaboration with cytokines from Kupffer cells...
  20. pmc Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-gamma production from activated B cells
    T Yoshimoto
    Department of Immunology, Hyogo College of Medicine, Nishinomiya, Japan
    Proc Natl Acad Sci U S A 94:3948-53. 1997
    b>Interleukin 18 (IL-18), originally called interferon (IFN)-gamma-inducing factor, is a recently cloned cytokine of approximately 18 kDa synthesized by Kupffer cells and activated macrophages...
  21. ncbi Defective NK cell activity and Th1 response in IL-18-deficient mice
    K Takeda
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
    Immunity 8:383-90. 1998
    ..We therefore generated mice lacking both IL-18 and IL-12. In these mice, NK activity and Th1 response were further impaired. This demonstrates the important role of both IL-18 and IL-12 in NK activity, as well as in in vivo Th1 response...
  22. ncbi Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
    O Adachi
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
    Immunity 9:143-50. 1998
    ..Taken together, these results demonstrate that MyD88 is a critical component in the signaling cascade that is mediated by IL-1 receptor as well as IL-18 receptor...
  23. pmc Role of interleukin-18 (IL-18) in mycobacterial infection in IL-18-gene-disrupted mice
    I Sugawara
    Department of Molecular Pathology, The Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, Kiyose, Tokyo 204 0022, Japan
    Infect Immun 67:2585-9. 1999
    ..Therefore, IL-18 is important for the generation of protective immunity to mycobacteria, and its main function is the induction of IFN-gamma expression...
  24. ncbi Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor
    K Hoshino
    Department of Appropriate Technology Development, Research Institute, International Medical Center of Japan, Tokyo, Japan
    J Immunol 162:5041-4. 1999
    ..Th1 cell development was also impaired in IL-1Rrp-deficient mice. These data demonstrate that IL-1Rrp is a ligand-binding receptor that is essential for IL-18-mediated signaling events...
  25. ncbi Differential antitumor effects of administration of recombinant IL-18 or recombinant IL-12 are mediated primarily by Fas-Fas ligand- and perforin-induced tumor apoptosis, respectively
    W Hashimoto
    Department of Surgery, University of Pittsburgh Cancer Institute, PA 15213, USA
    J Immunol 163:583-9. 1999
    ..We conclude that the antitumor effect of IL-18 is exerted predominantly through a Fas-dependent pathway. The perforin pathway, however, appears to be the predominant cytolytic pathway mediating IL-12 antitumor effects...
  26. ncbi Altered immune responses and susceptibility to Leishmania major and Staphylococcus aureus infection in IL-18-deficient mice
    X Q Wei
    Department of Immunology, University of Glasgow, United Kingdom
    J Immunol 163:2821-8. 1999
    ....
  27. ncbi IFN-gamma-inducing factor (IL-18) increases allergic sensitization, serum IgE, Th2 cytokines, and airway eosinophilia in a mouse model of allergic asthma
    J S Wild
    Department of Internal Medicine, Division of Allergy and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Immunol 164:2701-10. 2000
    ..This is the first report demonstrating that IL-18 promotes a Th2 phenotype in vivo, and potently induces allergic sensitization. These results suggest that IL-18 may contribute to the pathogenesis of allergic asthma...
  28. ncbi The role of IL-18 in innate immunity
    S Akira
    Department of Host Defense, CREST of Japan Science and Technology Corporation, Research Institute for Microbial Diseases, Osaka University, Suita, 565 0871, Japan
    Curr Opin Immunol 12:59-63. 2000
    ..The IL-18 receptor system and its signal transduction pathway are analogous to those of the IL-1 receptor. Mice deficient in IL-18 have demonstrated its critical role in natural killer cell activity and in vivo Th1 response...
  29. ncbi An IFN-gamma-independent proinflammatory role of IL-18 in murine streptococcal cell wall arthritis
    L A Joosten
    Rheumatology Research Laboratory and Department of Internal Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
    J Immunol 165:6553-8. 2000
    ..The present study indicates that IL-18 is a proinflammatory cytokine during the onset of murine SCW arthritis, and this inflammatory role of IL-18 is IFN-gamma independent...
  30. ncbi Reduced incidence and severity of collagen-induced arthritis in mice lacking IL-18
    X Q Wei
    Department of Immunology and Bacteriology, University of Glasgow, Glasgow, G11 6NT, United Kingdom
    J Immunol 166:517-21. 2001
    ..These data directly demonstrate a pivotal role of IL-18 in the development of inflammatory arthritis and suggest that antagonists to IL-18 may have therapeutic potential in rheumatic diseases...
  31. pmc Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure
    V Y Melnikov
    Department of Medicine, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    J Clin Invest 107:1145-52. 2001
    ..Finally, we confirmed histologically that caspase-1(-/-) mice show decreased neutrophil infiltration, indicating that the deleterious role of IL-18 in ischemic ARF may be due to increased neutrophil infiltration...
  32. ncbi A novel role for interleukin-18 in adhesion molecule induction through NF kappa B and phosphatidylinositol (PI) 3-kinase-dependent signal transduction pathways
    J C Morel
    Northwestern University Medical School, Department of Medicine, Chicago, Illinois, 60611, USA
    J Biol Chem 276:37069-75. 2001
    ..IL-18 requires NF kappa B as well as PI 3-kinase to induce VCAM-1 on RA synovial fibroblasts, suggesting that there may be two distinct pathways in IL-18-induced adhesion molecule expression...
  33. pmc Enhanced gamma interferon production through activation of Valpha14(+) natural killer T cells by alpha-galactosylceramide in interleukin-18-deficient mice with systemic cryptococcosis
    K Kawakami
    First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
    Infect Immun 69:6643-50. 2001
    ..Our results indicated that in IL-18KO mice, IFN-gamma synthesis was enhanced through overproduction of IL-12 and IL-4 after intravenous infection with C. neoformans and a ligand-specific activation of Valpha14(+) NKT cells...
  34. ncbi Interleukin-18 induces rheumatoid arthritis synovial fibroblast CXC chemokine production through NFkappaB activation
    J C Morel
    Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, USA
    Lab Invest 81:1371-83. 2001
    ..These results indicate a novel role for IL-18 in inducing RA synovial fibroblast expression of CXC chemokines through NFkappaB and place this cytokine in a strategic role in the local inflammation observed in RA...
  35. ncbi Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism
    K Adachi
    Department of Immunology and Medical Zoology, Institute for Advanced Medical Science, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    J Immunol 167:5928-34. 2001
    ..berghei infection of mice induces activation of the TLR-MyD88 signaling pathway which results in IL-12 production and activation of the perforin-dependent cytotoxic activities of MHC-unrestricted hepatic lymphocytes...
  36. pmc Interleukin-18 regulates acute graft-versus-host disease by enhancing Fas-mediated donor T cell apoptosis
    P Reddy
    Department of Internal Medicine and Pediatrics, University of Michigan Cancer Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109, USA
    J Exp Med 194:1433-40. 2001
    ..Together, these results demonstrate that IL-18 regulates acute GVHD by inducing enhanced Fas-mediated apoptosis of donor T cells early after BMT, and donor IFN-gamma is critical for this protective effect...
  37. ncbi IL-18 improves the early antimicrobial host response to pneumococcal pneumonia
    Fanny N Lauw
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Immunol 168:372-8. 2002
    ..These data suggest that endogenous IL-18, but not IL-12, plays an important role in the early antibacterial host response during pneumococcal pneumonia...
  38. ncbi Interleukin 18 (IL-18) in synergy with IL-2 induces lethal lung injury in mice: a potential role for cytokines, chemokines, and natural killer cells in the pathogenesis of interstitial pneumonia
    Masaki Okamoto
    Department of Internal Medicine, Kurume University School of Medicine, Japan
    Blood 99:1289-98. 2002
    b>Interleukin 18 (IL-18) was discovered as an interferon-gamma (IFN-gamma)-inducing factor and plays important roles in natural killer (NK) cell activation...
  39. ncbi Cutting edge: a murine, IL-12-independent pathway of IFN-gamma induction by gram-negative bacteria based on STAT4 activation by Type I IFN and IL-18 signaling
    Marina A Freudenberg
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    J Immunol 169:1665-8. 2002
    ..This pathway participates in the induction of IFN-gamma by Gram-negative bacteria and is therefore expected to play a role whenever IFN-alpha or IFN-beta and IL-18 are produced concomitantly during bacterial, viral, or other infections...
  40. ncbi The vaccinia virus C12L protein inhibits mouse IL-18 and promotes virus virulence in the murine intranasal model
    Julian A Symons
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, UK
    J Gen Virol 83:2833-44. 2002
    ..However, infection of BALB/c mice by the intranasal route showed that the deletion mutant was attenuated and induced lower weight loss and signs of illness compared to controls...
  41. pmc Neutrophil-independent mechanisms of caspase-1- and IL-18-mediated ischemic acute tubular necrosis in mice
    Vyacheslav Y Melnikov
    Department of Medicine, University of Colorado School of Medicine, 4200 East 9th Avenue, Denver, Colorado 80262, USA
    J Clin Invest 110:1083-91. 2002
    ..These results suggest a novel neutrophil-independent mechanism of IL-18-mediated ischemic ARF...
  42. ncbi Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice
    Rima Elhage
    Department of Medicine at Karolinska Hospital and Center for Molecular Medicine L8 03, Karolinska Institute, SE 17176 Stockholm, Sweden
    Cardiovasc Res 59:234-40. 2003
    ..Nai;ve CD4+ T cells differentiate into interferon-gamma (IFN-gamma) producing Th1 effector cells when stimulated by interleukin-18 (IL-18) and IL-12. We wanted to directly test whether the Th1 pathway is proatherogenic...
  43. ncbi IL-18 enhances collagen-induced arthritis by recruiting neutrophils via TNF-alpha and leukotriene B4
    Claudio A Canetti
    Department of Pharmacology, School of Medicine Ribeirao Preto, University of Sao Paulo, Sao Paulo, Brazil
    J Immunol 171:1009-15. 2003
    ..Together, these findings provide a novel mechanism whereby IL-18 can promote inflammatory diseases...
  44. ncbi IL-18 binding protein protects against contact hypersensitivity
    Thomas Plitz
    Department of Immunology, Serono Pharmaceutical Research Institute, Geneva, Switzerland
    J Immunol 171:1164-71. 2003
    ..Taken together with the evidence that IL-18 is present in tissue samples of the human disease, our data reinforces IL-18BP as a candidate for this therapeutic indication...
  45. ncbi Exacerbated and prolonged allergic and non-allergic inflammatory cutaneous reaction in mice with targeted interleukin-18 expression in the skin
    Yusuke Kawase
    R and D Laboratories, Nippon Organon K K, Osaka, Japan
    J Invest Dermatol 121:502-9. 2003
    b>Interleukin 18 induces both T helper 1 and T helper 2 cytokines, proinflammatory cytokines, chemokines, and IgE and IgG1 production. A role of interleukin 18 in inflammatory cutaneous reactions is still unclear, however...
  46. ncbi TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver
    Kazuyoshi Takeda
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bukyou ku, Tokyo 113 8421, Japan
    Blood 105:2082-9. 2005
    ..This study is the first to describe the concomitant maturation of NK cell effector function with surface phenotype in vivo and implies an important defense role for NK cell TRAIL in the developing immune system...
  47. ncbi IL-18 accelerates atherosclerosis accompanied by elevation of IFN-gamma and CXCL16 expression independently of T cells
    Charlotta Tenger
    Centre for Molecular Medicine and Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 25:791-6. 2005
    ..We therefore investigated whether cells other than activated T cells can play a proatherogenic role via IFN-gamma secretion under the stimulation of IL-18 in vivo...
  48. pmc Enhanced viral clearance in interleukin-18 gene-deficient mice after pulmonary infection with influenza A virus
    Koenraad F Van Der Sluijs
    Laboratory of Experimental Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands
    Immunology 114:112-20. 2005
    ..Tumour necrosis factor-alpha production by CD4(+) T cells was significantly lower in IL-18(-/-) mice than in wildtype mice. Our data indicate that endogenous IL-18 impairs viral clearance during influenza A infection...
  49. pmc MyD88, but not toll-like receptors 4 and 2, is required for efficient clearance of Brucella abortus
    David S Weiss
    Max Planck Institut für Infektionsbiologie, Campus Charite Mitte, Schumannstrasse 21 22, Berlin D 10117, Germany
    Infect Immun 73:5137-43. 2005
    ....
  50. ncbi Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity
    Christopher E Andoniou
    Immunology and Virology Program, Centre for Ophthalmology and Visual Science, The University of Western Australia, Crowley 6009, Western Australia, Australia
    Nat Immunol 6:1011-9. 2005
    ..receptor and NKG2D ligand, whereas the production of interferon-gamma by NK cells relied mainly on DC-derived interleukin 18. Although Toll-like receptor 9 contributes to antiviral immunity, we found that signaling pathways independent ..
  51. pmc Contribution of IL-18 to atopic-dermatitis-like skin inflammation induced by Staphylococcus aureus product in mice
    Makoto Terada
    Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya 663 8501, Japan
    Proc Natl Acad Sci U S A 103:8816-21. 2006
    ..b>il18-/-BALB/c mice similarly evaded SDS/SpA-induced AD...
  52. ncbi IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation
    Min Jong Kang
    Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 178:1948-59. 2007
    ..They also demonstrate, in a murine modeling system, that IL-18R signaling plays a critical role in the pathogenesis of CS-induced inflammation and emphysema...
  53. ncbi Pulmonary inflammation and emphysema: role of the cytokines IL-18 and IL-13
    Tomoaki Hoshino
    Department of Internal Medicine 1, Kurume University School of Medicine, Kurume, Japan
    Am J Respir Crit Care Med 176:49-62. 2007
    ..Our results demonstrate that IL-18 overproduction in the lungs can induce lung diseases, such as pulmonary inflammation, lung fibrosis, and COPD...
  54. ncbi IL-18 is a key proximal mediator of contact hypersensitivity and allergen-induced Langerhans cell migration in murine epidermis
    Christos Antonopoulos
    St John s Institute of Dermatology, King s College London, London, United Kingdom
    J Leukoc Biol 83:361-7. 2008
    ..These data indicate that IL-18 is a key proximal mediator of LC migration and CHS, acting upstream of IL-1 beta and TNF-alpha, and may play a central role in regulation of cutaneous immune responses...
  55. pmc Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis
    Jeremy B Swann
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria 3002, Australia
    Proc Natl Acad Sci U S A 105:652-6. 2008
    ..Overall, these data not only confirm the key role that MyD88 plays in promoting tumor development but also demonstrate that inflammation-induced carcinogenesis and cancer immunoediting can indeed occur in the same mouse tumor model...
  56. pmc Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3
    Hanfen Li
    Department Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Immunol 181:17-21. 2008
    ....
  57. pmc Cutting edge: Priming of NK cells by IL-18
    Julie Chaix
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Institut National de la Santé et de la Recherche Médicale Unité, Centre National de la Recherche Scientifique Unité Mixte de Recherche 6102, Marseille, France
    J Immunol 181:1627-31. 2008
    ..This suggests that priming by IL-18 leads to an improved translation of IFN-gamma mRNA. These results reveal a novel type of cooperation between IL-12 and IL-18 that requires the sequential action of these cytokines...
  58. ncbi A novel role for neutrophils as critical activators of NK cells
    Roman Spörri
    ETH Zurich, Institute for Microbiology, Zurich, Switzerland
    J Immunol 181:7121-30. 2008
    ..We propose a novel central role for neutrophils as essential IL-18 producers and hence NK cell "helpers" in bacterial infection...
  59. pmc Interleukin-18-related genes are induced during the contraction phase but do not play major roles in regulating the dynamics or function of the T-cell response to Listeria monocytogenes infection
    Jodie S Haring
    Department of Microbiology, 3 512 BSB, University of Iowa, 51 Newton Road, Iowa City, IA 52242, USA
    Infect Immun 77:1894-903. 2009
    ..monocytogenes infection...
  60. doi Role of proinflammatory cytokines IL-18 and IL-1beta in bleomycin-induced lung injury in humans and mice
    Tomoaki Hoshino
    Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume 830 0011, Japan
    Am J Respir Cell Mol Biol 41:661-70. 2009
    ..Thus, our results provide evidence for an important role of IL-1beta and IL-18 in chemotherapy-induced lung injury...
  61. doi IL-18 neutralization ameliorates obstruction-induced epithelial-mesenchymal transition and renal fibrosis
    Ahmad H Bani-Hani
    Department of Urology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Kidney Int 76:500-11. 2009
    ..Our study demonstrates that IL-18 is a significant mediator of obstruction-induced renal fibrosis and epithelial- mesenchymal transition independent of downstream TGF-beta1 or TNF-alpha production...
  62. doi IL-12p40 and IL-18 play pivotal roles in orchestrating the cell-mediated immune response to a poxvirus infection
    Yang Wang
    John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
    J Immunol 183:3324-31. 2009
    ..Taken together, our data indicate that IL-12p40 and IL-18 act in concert and play an important antiviral role through the up-regulation of IFN-gamma production and cell-mediated immune responses...
  63. pmc MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18
    Rosalba Salcedo
    Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21701, USA
    J Exp Med 207:1625-36. 2010
    ..However, upon AOM/DSS treatment Il18(-/-) and Il18r1(-/-) mice were more susceptible to colitis and polyp formation than wild-type mice, suggesting that ..
  64. pmc Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
    Edward A Miao
    Institute for Systems Biology, Seattle, Washington, USA
    Nat Immunol 11:1136-42. 2010
    ..This demonstrates that activation of caspase-1 clears intracellular bacteria in vivo independently of IL-1β and IL-18 and establishes pyroptosis as an efficient mechanism of bacterial clearance by the innate immune system...
  65. pmc IL-18 mediates proapoptotic signaling in renal tubular cells through a Fas ligand-dependent mechanism
    Hongji Zhang
    Department of Urology, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Physiol Renal Physiol 301:F171-8. 2011
    ..This study reveals that IL-18 is a significant mediator of obstruction-induced tubular cell apoptosis, and it demonstrates that IL-18 stimulates proapoptotic signaling through a FasL-dependent mechanism...
  66. pmc NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis
    Eran Elinav
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 145:745-57. 2011
    ..Altogether, perturbations in this inflammasome pathway, including NLRP6, ASC, caspase-1, and IL-18, may constitute a predisposing or initiating event in some cases of human IBD...
  67. pmc IL-18 induces emphysema and airway and vascular remodeling via IFN-γ, IL-17A, and IL-13
    Min Jong Kang
    Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8056, USA
    Am J Respir Crit Care Med 185:1205-17. 2012
    ..Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation, alveolar destruction, and airway and vascular remodeling. However, the mechanisms that lead to these diverse alterations have not been defined...
  68. pmc A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread
    Wolfgang Kastenmuller
    Lymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 150:1235-48. 2012
    ....
  69. ncbi Cutting edge: selective IL-18 requirements for induction of compartmental IFN-gamma responses during viral infection
    G C Pien
    Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    J Immunol 165:4787-91. 2000
    ..Taken together, our results delineate contrasting compartmental requirements for IL-18 and suggest that preservation of local, hepatic IFN-gamma production is critical for host defense during murine cytomegalovirus challenge...
  70. pmc Interleukin (IL)-18 induces Langerhans cell migration by a tumour necrosis factor-alpha- and IL-1beta-dependent mechanism
    M Cumberbatch
    Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, UK and Centre for Dermatology, University College London, UK
    Immunology 102:323-30. 2001
    ..Importantly, not only was IL-18 able to contribute to the regulation of LC migration, it was found to be essential for the manifestation of these processes in response to topical sensitization with the contact allergen oxazolone...
  71. ncbi Contrasting action of IL-12 and IL-18 in the development of dextran sodium sulphate colitis in mice
    H Takagi
    Dept of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Scand J Gastroenterol 38:837-44. 2003
    ..The present study was conducted to determine the distinct roles of IL-12 and IL-18 in the development of dextran sulphate sodium (DSS) colitis in mice...
  72. pmc Endogenous interleukin-18 improves the early antimicrobial host response in severe melioidosis
    W Joost Wiersinga
    Academic Medical Center, Meibergdreef 9, Room G2 132, 1105 AZ Amsterdam, The Netherlands
    Infect Immun 75:3739-46. 2007
    ..Together, these data indicate that the enhanced production of IL-18 in melioidosis is an essential part of a protective immune response to this severe infection...
  73. pmc Cutting edge: the mechanism of invariant NKT cell responses to viral danger signals
    Aaron J Tyznik
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 181:4452-6. 2008
    ..Consequently, iNKT cells have the ability to respond to a variety of microbes, including viruses, in an Ag-independent manner, suggesting they may play a broad role in antipathogen defenses despite their limited TCR repertoire...
  74. pmc Macrophages are not the source of injurious interleukin-18 in ischemic acute kidney injury in mice
    Zhibin He
    Division of Renal Diseases, University of Colorado Denver and the Health Sciences Center, Aurora, Colorado 80262, USA
    Am J Physiol Renal Physiol 296:F535-42. 2009
    ..In conclusion, IL-18 from adoptive transfer of macrophages is not sufficient to cause ischemic AKI...
  75. pmc IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions
    Hiroshi Konishi
    Department of Dermatology, Mie University School of Medicine, Tsu 514 8507, Japan
    Proc Natl Acad Sci U S A 99:11340-5. 2002
    ..Our present study might provide insight into understanding the pathogenesis of and establishing therapeutics for chronic inflammatory skin diseases including AD...
  76. ncbi IL-18 regulates intestinal mastocytosis and Th2 cytokine production independently of IFN-gamma during Trichinella spiralis infection
    Helena Helmby
    School of Biological Sciences, University of Manchester, United Kingdom
    J Immunol 169:2553-60. 2002
    ..Hence, IL-18 plays a significant biological role as a negative regulator of intestinal mast cell responses and may promote the survival of intestinal parasites in vivo...
  77. ncbi IL-12p40 and IL-18 in crescentic glomerulonephritis: IL-12p40 is the key Th1-defining cytokine chain, whereas IL-18 promotes local inflammation and leukocyte recruitment
    A Richard Kitching
    Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, 246 Clayton Road, Clayton, Victoria 3168, Australia
    J Am Soc Nephrol 16:2023-33. 2005
    ..These studies demonstrate that in severe experimental crescentic GN, IL-12p40 is the key Th1-defining cytokine chain, whereas IL-18 has local proinflammatory roles...
  78. pmc An IFN-gamma-IL-18 signaling loop accelerates memory CD8+ T cell proliferation
    Yoshiko Iwai
    Laboratory of Cellular Immunology and Physiology, The Rockefeller University, New York, New York, United States of America
    PLoS ONE 3:e2404. 2008
    ..These results indicate that a positive regulatory loop involving IFN-gamma and IL-18 signaling contributes to the accelerated memory CD8(+) T cell proliferation during a recall response to antigen presented by DCs...
  79. doi Inflammasome-dependent IFN-γ drives pathogenesis in Streptococcus pneumoniae meningitis
    Andrew J Mitchell
    Sydney Medical School, University of Sydney, Camperdown, New South Wales 2050, Australia
    J Immunol 189:4970-80. 2012
    ..Together, these data suggest that inflammasome-dependent IFN-γ contributes via multiple pathways to pathology during S. pneumoniae meningitis...
  80. ncbi The role of IL-18 in blood-stage immunity against murine malaria Plasmodium yoelii 265 and Plasmodium berghei ANKA
    Ram Pyare Singh
    Malaria Research Group, International Center for Genetic Engineering and Biotechnology, New Delhi, India
    J Immunol 168:4674-81. 2002
    ..berghei ANKA than were wild-type C57BL/6 mice. These data suggest that IL-18 plays a protective role in host defense by enhancing IFN-gamma production during blood-stage infection by murine malaria...
  81. ncbi Interleukin-18 involvement in hypoxic-ischemic brain injury
    Maj Hedtjarn
    Department of Physiology and Pharmacology, Perinatal Center, Goteborg University, 405 30 Goteborg, Sweden
    J Neurosci 22:5910-9. 2002
    ..In conclusion, we found that IL-18 expression in microglia was markedly increased after HI and that IL-18 appears to be important for the development of HI brain injury...
  82. ncbi Mice lacking myeloid differentiation factor 88 display profound defects in host resistance and immune responses to Mycobacterium avium infection not exhibited by Toll-like receptor 2 (TLR2)- and TLR4-deficient animals
    Carl G Feng
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8003, USA
    J Immunol 171:4758-64. 2003
    ....
  83. ncbi Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: critical role of myeloid differentiation factor 88
    Leo A B Joosten
    Rheumatology Research Laboratory and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Immunol 171:6145-53. 2003
    ..Since agonists of the Toll-like pathway are abundantly involved in both septic and rheumatoid arthritis, targeting of MyD88 may be a novel therapy in inflammatory joint diseases...
  84. pmc IL-18 with IL-2 protects against Strongyloides venezuelensis infection by activating mucosal mast cell-dependent type 2 innate immunity
    Yuki Sasaki
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Japan
    J Exp Med 202:607-16. 2005
    ..Neutralization of IL-18 and IL-2 further reduces expulsion in infected STAT6(-/-) mice. These results suggest that collaboration between IL-18-dependent and Th2 cell-dependent mastocytosis is important for prompt parasite expulsion...
  85. doi Reduced expression of IL-18 is a marker of ultraviolet radiation-induced melanomas
    Elke Hacker
    Oncogenomics Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Int J Cancer 123:227-31. 2008
    ..validated using qRT-PCR, which confirmed upregulation of Gpr155 and Bmp7, and downregulation of Plagl1, Akap12 and Il18 in UVR-induced mouse melanomas...
  86. pmc Prointerleukin-18 is activated by meprin beta in vitro and in vivo in intestinal inflammation
    Sanjita Banerjee
    Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 283:31371-7. 2008
    ..This study identifies proIL-18 as a biologically important substrate for meprin beta and implicates meprins in the modulation of inflammation...
  87. doi IL-18 induces a marked gene expression profile change and increased Ccl1 (I-309) production in mouse mucosal mast cell homologs
    Zoltan Wiener
    Department of Genetics, Cell and Immunobiology, Semmelweis University, H 1089 Budapest, Nagyvarad ter 4, Hungary
    Int Immunol 20:1565-73. 2008
    ..The Ccl1 receptor (CCR8) is known to be expressed by T(h)2 cells and is involved in their recruitment. Our present findings suggest that IL-18 may contribute to mast cell-influenced Th2 responses by inducing Ccl1 production...
  88. doi Thymocyte-synthesized glucocorticoids play a role in thymocyte homeostasis and are down-regulated by adrenocorticotropic hormone
    Shengjun Qiao
    Department of Microbiology, Tumor, and Cell Biology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Endocrinology 150:4163-9. 2009
    ..We conclude that thymocyte-produced GCs are important for the homeostasis of adult mouse thymocytes and that high ACTH level, in contrast to stimulating GC synthesis in the adrenal glands, has the opposite effect in thymocytes...
  89. pmc The role of sex hormones in the development of Th2 immunity in a gender-biased model of Trichuris muris infection
    Matthew R Hepworth
    Faculty of Life Sciences, University of Manchester, Manchester, England, UK
    Eur J Immunol 40:406-16. 2010
    ....
  90. pmc Behavioral and genetic investigations of low exploratory behavior in Il18r1(-/-) mice: we can't always blame it on the targeted gene
    Amy F Eisener-Dorman
    Wadsworth Center, New York State Department of Health, 150 New Scotland Ave, Albany, NY 12208, USA
    Brain Behav Immun 24:1116-25. 2010
    ..In the current study we confirm the generalizability of those earlier findings, by assessing behavior in Il18(-/-) and Il18r1(-/-) knockout mice...
  91. pmc ApoE-/- PGC-1α-/- mice display reduced IL-18 levels and do not develop enhanced atherosclerosis
    Sokrates Stein
    Cardiovascular Research, Institute of Physiology, and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    PLoS ONE 5:e13539. 2010
    ..The aim of this study was to analyze total PGC-1α deficiency in an atherosclerotic mouse model...
  92. pmc Panhistone deacetylase inhibitors inhibit proinflammatory signaling pathways to ameliorate interleukin-18-induced cardiac hypertrophy
    Gipsy Majumdar
    Department of Veterans Affairs Medical Center, University of Tennessee Health Science Center, Memphis, TN 38104, USA
    Physiol Genomics 43:1319-33. 2011
    ..Evidently, both TSA and CBHA caused a two- to fourfold induction of phosphatase and tensin homolog expression to counteract IL-18-induced proinflammatory signaling and cardiac hypertrophy...
  93. pmc Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis
    C M Coughlin
    Biomedical Graduate Program, Institute for Human Gene Therapy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 101:1441-52. 1998
    ..This suggests that inhibition of tumor angiogenesis is an important part of the systemic antitumor effect produced by mIL-12 and mIL-18...
  94. ncbi IL-18-deficient mice are resistant to endotoxin-induced liver injury but highly susceptible to endotoxin shock
    Y Sakao
    Department of Biochemistry, Hyogo College of Medicine, Nishinomiya, Japan
    Int Immunol 11:471-80. 1999
    ..Taken together, these findings demonstrate that IL-18 is responsible for the progression of endotoxin-induced liver injury as well as down-regulation of endotoxin-induced TNF-alpha production in P. acnes-primed mice...
  95. ncbi An alternate pathway for type 1 T cell differentiation
    C Feng
    Department of Microbiology and Immunology, Ehime University School of Medicine, Shigenobu, Ehime 791 0295, Japan
    Int Immunol 11:1185-94. 1999
    ..This leads to the hypothesis that the IL-12-independent novel pathway for inducing IFN-gamma-producing T cells is distinct from the classical type 1/type 2 T cell subset differentiation pathway...
  96. ncbi Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemia
    M G Netea
    Departments ofMedicine and Surgery, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 164:2644-9. 2000
    ..coli LPS) or TNF (S. typhimurium LPS) synthesis by anti-IL-18 treatment may also be involved...
  97. ncbi Identification and initial characterization of four novel members of the interleukin-1 family
    S Kumar
    Department of Bone and Cartilage Biology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406, USA
    J Biol Chem 275:10308-14. 2000
    ..This suggests that IL-1H1 may be involved in pathogenesis of immune mediated disease processes. The addition of four novel IL-1 homologues suggests that the IL-1 family is significantly larger than previously thought...
  98. ncbi Porcine interleukin 18: cloning, characterization of the cDNA and expression with the baculovirus system
    Y Muneta
    National Institute of Animal Health, Tsukuba, Ibaraki, 305 0856, Japan
    Cytokine 12:566-72. 2000
    We have isolated and sequenced a cDNA that contains the coding sequence of porcine interleukin 18 (IL-18) and the recombinant protein of porcine IL-18 was expressed using the baculovirus system...
  99. ncbi IL-18 not required for IRBP peptide-induced EAU: studies in gene-deficient mice
    H R Jiang
    Department of Ophthalmology, University of Aberdeen Medical School Foresterhill, Aberdeen, United Kingdom
    Invest Ophthalmol Vis Sci 42:177-82. 2001
    ..The initial studies were conducted to detect the expression of IL-18 in normal mouse eye tissue, and the later studies investigated induction of EAU in mice with an IL-18(-/-) phenotype...
  100. ncbi Independent and synergistic effects of interleukin-18 and interleukin-12 in augmenting cytotoxic T lymphocyte responses and IFN-gamma production in aging
    Y Zhang
    Influenza Research Center, Respiratory Pathogens Research Unit, Department of Microbiology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    J Interferon Cytokine Res 21:843-50. 2001
    ..Potentially, IL-18 and IL-12 can augment IFN-gamma production and reverse CD8(+) CTL deficiency in aging, independently or synergistically...
  101. ncbi RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems
    Koichi Kobayashi
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 416:194-9. 2002
    ..Rip2 is therefore a signal transducer and integrator of signals for both the innate and adaptive immune systems...

Research Grants12

  1. Role of the CRF2 Receptor in Ingestive Behavior
    Eric Zorrilla; Fiscal Year: 2005
    ..The proposed studies will address these questions as well to understand better the role of the CRF2 receptor in feeding behavior. ..
  2. Programmed adiposity: genetic in utero and postnatal determinants
    Eric Zorrilla; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  3. Galanin Control of Food Intake: Molecular, Neuroanatomical and Behavioral Bases
    Eric P Zorrilla; Fiscal Year: 2010
    ....
  4. Urocortins Brain CRF2 Receptors and Energy Balance
    Eric P Zorrilla; Fiscal Year: 2010
    ....
  5. Chemokines, nitric oxide, and myocardial depression
    Bysani Chandrasekar; Fiscal Year: 2005
    ..The results from these studies will further our knowledge of chemokine biology and lead to new therapeutic strategies to prevent or treat myocardial dysfunction in ischemia-reperfusion injury. ..
  6. HOST IMMUNOREGULATION OF ANTILEISHMANIAL CHEMOTHERAPY
    Henry Murray; Fiscal Year: 2005
    ..And Aim 3: Characterize immunostimulation in AmB's efficacy, and in recrudescent infection following AmB therapy, pinpoint the likely cytokine-driven T cell mechanism which prevents post-treatment relapse. ..
  7. Development of a vaccine for murine Lyme disease
    Linden Hu; Fiscal Year: 2006
    ..burgdorferi to mice and in sterilizing infection in infected ticks. ..
  8. Accelerated arthritis in E and P selectin deficient mice
    Jeffrey Ruth; Fiscal Year: 2007
    ..While common dogma suggests IL-1beta regulates selectins, this study proposes the novel hypothesis that in vivo E- and P-selectins regulate IL-1beta production and CIA development. [unreadable] [unreadable] [unreadable]..
  9. The regulation of tumor immunity by NKT cells
    Mark Smyth; Fiscal Year: 2007
    ..This proposal focuses clearly on a pivotal immune control mechanism that will influence many current and future immunotherapies. ..
  10. Neoadjuvant Cytokine Immunotherapy by PLA Microspheres
    Michael Sabel; Fiscal Year: 2007
    ..I will pursue this area of investigation as a full-time faculty member, with full commitment from the Department of General Surgery and the Division of Surgical Oncology at the University of Michigan Medical Center. ..
  11. Host Immunoregulation of Response to Antileishmanial Chemotherapy
    Henry Murray; Fiscal Year: 2007
    ..abstract_text> ..
  12. Bacterial immunomodulation in periodontitis
    Linden Hu; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..