Il15

Summary

Gene Symbol: Il15
Description: interleukin 15
Alias: AI503618, IL-15, interleukin-15
Species: mouse

Top Publications

  1. ncbi NK cells play a critical protective role in host defense against acute extracellular Staphylococcus aureus bacterial infection in the lung
    Cherrie Lee Small
    Department of Pathology and Molecular Medicine, Division of Infectious Diseases, Center for Gene Therapeutics, McMaster University, Hamilton, Ontario, L8N 3Z5, Canada
    J Immunol 180:5558-68. 2008
  2. ncbi Enforced expression of Bcl-2 partially restores cell numbers but not functions of TCRgammadelta intestinal intraepithelial T lymphocytes in IL-15-deficient mice
    Kenji Nakazato
    Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Immunol 178:757-64. 2007
  3. ncbi c-Myc acts downstream of IL-15 in the regulation of memory CD8 T-cell homeostasis
    Teresa Bianchi
    Ludwig Institute for Cancer Research LICR, Ch des Boveresses 155, 1066 Epalinges, Switzerland
    Blood 107:3992-9. 2006
  4. ncbi Cutting edge: transpresentation of IL-15 by bone marrow-derived cells necessitates expression of IL-15 and IL-15R alpha by the same cells
    Michelle M Sandau
    Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 173:6537-41. 2004
  5. ncbi Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis
    Sylvie Ferrari-Lacraz
    Department of Medicine, Harvard Medical School, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Immunol 173:5818-26. 2004
  6. ncbi Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation
    Seiichi Kuwajima
    Department of Immunology, Akita University School of Medicine, Akita 010 8543, Japan
    Nat Immunol 7:740-6. 2006
  7. ncbi Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance
    Hisataka Kobayashi
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 105:721-7. 2005
  8. pmc IL-7 is critical for homeostatic proliferation and survival of naive T cells
    J T Tan
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:8732-7. 2001
  9. ncbi Interleukin-15 induces IL-12 receptor beta1 gene expression through PU.1 and IRF 3 by targeting chromatin remodeling
    Tipayaratn Musikacharoen
    Division of Biochemistry and Molecular Dentistry, Department of Developmental Medicine, Kagoshima University, Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Blood 105:711-20. 2005
  10. pmc SOCS-1 regulates IL-15-driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential
    Gayle M Davey
    The Walter and Eliza Hall Institute of Medical Research, Parkville, 3050 Victoria, Australia
    J Exp Med 202:1099-108. 2005

Research Grants

  1. THERAPY FOR AIDS CENTRAL NERVOUS SYSTEM LYMPHOMA
    Michael Caligiuri; Fiscal Year: 2002
  2. Mechanisms of CTLA-4 Function
    Joonsoo Kang; Fiscal Year: 2007
  3. Regulation of T cell development by SOX13
    Joonsoo Kang; Fiscal Year: 2009
  4. POLARIZING T CELL RESPONSES IN VIVO WITH DENDRITIC CELLS
    Bali Pulendran; Fiscal Year: 2010
  5. IL-15, Body Compositition and Insulin Sensivity in Aging
    LeBris S Quinn; Fiscal Year: 2010
  6. Transport of TNFalpha across the BBB
    Weihong Pan; Fiscal Year: 2008
  7. Transport of neurotrophic cytokines after spinal cord injury
    Weihong Pan; Fiscal Year: 2007
  8. The immune response to latent gammaherpesvirus antigens
    Edward Usherwood; Fiscal Year: 2003
  9. The regulation of tumor immunity by NKT cells
    Mark Smyth; Fiscal Year: 2007
  10. MODULATING HIV-IMMUNITY WITH DENDRITIC CELLS
    Bali Pulendran; Fiscal Year: 2004

Scientific Experts

Detail Information

Publications146 found, 100 shown here

  1. ncbi NK cells play a critical protective role in host defense against acute extracellular Staphylococcus aureus bacterial infection in the lung
    Cherrie Lee Small
    Department of Pathology and Molecular Medicine, Division of Infectious Diseases, Center for Gene Therapeutics, McMaster University, Hamilton, Ontario, L8N 3Z5, Canada
    J Immunol 180:5558-68. 2008
    ..These findings hold implication for the development of therapeutics in treating antibiotic-resistant S. aureus infection...
  2. ncbi Enforced expression of Bcl-2 partially restores cell numbers but not functions of TCRgammadelta intestinal intraepithelial T lymphocytes in IL-15-deficient mice
    Kenji Nakazato
    Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Immunol 178:757-64. 2007
    ....
  3. ncbi c-Myc acts downstream of IL-15 in the regulation of memory CD8 T-cell homeostasis
    Teresa Bianchi
    Ludwig Institute for Cancer Research LICR, Ch des Boveresses 155, 1066 Epalinges, Switzerland
    Blood 107:3992-9. 2006
    ..Collectively, our data identify c-Myc as a novel downstream component of the IL-15-dependent pathway controlling homeostatic proliferation of memory CD44(high) CD8 T cells...
  4. ncbi Cutting edge: transpresentation of IL-15 by bone marrow-derived cells necessitates expression of IL-15 and IL-15R alpha by the same cells
    Michelle M Sandau
    Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 173:6537-41. 2004
    ..These data argue that soluble forms of IL-15 are irrelevant for physiological responses to this cytokine, and the implications of this finding are discussed...
  5. ncbi Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis
    Sylvie Ferrari-Lacraz
    Department of Medicine, Harvard Medical School, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Immunol 173:5818-26. 2004
    ..Our study suggests that the effective targeting of IL-15R-triggered events with CRB-15 can be of therapeutic importance in the treatment of rheumatoid arthritis...
  6. ncbi Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation
    Seiichi Kuwajima
    Department of Immunology, Akita University School of Medicine, Akita 010 8543, Japan
    Nat Immunol 7:740-6. 2006
    The function of interleukin 15 (IL-15) in unmethylated CpG oligodeoxynucleotide (CpG)-induced immune responses remains unknown...
  7. ncbi Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance
    Hisataka Kobayashi
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 105:721-7. 2005
    b>Interleukin 15 (IL-15) is a critical factor for the proliferation and activation of natural killer (NK) and CD8 T cells...
  8. pmc IL-7 is critical for homeostatic proliferation and survival of naive T cells
    J T Tan
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:8732-7. 2001
    ..Thus, naïve T cells disappeared gradually over a 1-month period upon adoptive transfer into IL-7(-) hosts. These findings indicate that naive T cells depend on IL-7 for survival and homeostatic proliferation...
  9. ncbi Interleukin-15 induces IL-12 receptor beta1 gene expression through PU.1 and IRF 3 by targeting chromatin remodeling
    Tipayaratn Musikacharoen
    Division of Biochemistry and Molecular Dentistry, Department of Developmental Medicine, Kagoshima University, Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Blood 105:711-20. 2005
    ..Thus, IL-15 induces chromatin remodeling of the IL12RB1 gene promoter, increasing IL12RB1 mRNA expression in synergy with IFN-gamma through the recruitment of PU.1 and IRF3...
  10. pmc SOCS-1 regulates IL-15-driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential
    Gayle M Davey
    The Walter and Eliza Hall Institute of Medical Research, Parkville, 3050 Victoria, Australia
    J Exp Med 202:1099-108. 2005
    ..Therefore, impaired deletion of highly autoreactive CD8 T cells, together with uncontrolled activation of naive CD8 T cells by homeostatic survival ligands, may provide a basis for the T cell-mediated disease of SOCS-1-/- mice...
  11. pmc Interleukin-15 is critical in the pathogenesis of influenza a virus-induced acute lung injury
    Risa Nakamura
    Division of Host Defence, Research Center for Prevention of Infectious Diseases, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Virol 84:5574-82. 2010
    ..These results indicate that IL-15-dependent CD8(+) T cells are at least partly responsible for the pathogenesis of acute pneumonia caused by influenza A virus...
  12. pmc Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo
    Thomas A Stoklasek
    Department of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    J Immunol 177:6072-80. 2006
    ..These findings hold significant importance for the use of IL-15 as a potential adjuvant/therapeutic and inducer of homeostatic proliferation, without the necessity for prior immunodepletion...
  13. pmc IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development
    Kieng B Vang
    Center for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 181:3285-90. 2008
    ....
  14. pmc Lack of IL-15 results in the suboptimal priming of CD4+ T cell response against an intracellular parasite
    Crescent L Combe
    Department of Microbiology, Parasitology, and Immunology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Proc Natl Acad Sci U S A 103:6635-40. 2006
    ..Furthermore, based on these observations, targeting of IL-15 should have a beneficial effect on individuals suffering from CD4+ T cell-mediated autoimmune diseases...
  15. pmc Interleukin-15 stimulates macrophages to activate CD4+ T cells: a role in the pathogenesis of rheumatoid arthritis?
    Rene Rückert
    Department of Immunology and Cell Biology, Research Center Borstel, Parkallee 22, Borstel, Germany
    Immunology 126:63-73. 2009
    ..In view of high serum and synovial levels of IL-15 in patients with RA, our data suggest the possibility that this excess IL-15 in RA may stimulate monocytes/MPhi to activate the characteristic autoreactive CD4(+) T cells in RA...
  16. pmc IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice
    J Marks-Konczalik
    Metabolism Branch, Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:11445-50. 2000
    ..IL-15 thus seems to contribute to enhanced immune memory by selectively propagating memory T cells and by blocking T cell death mediated by IL-2...
  17. ncbi IL-15 and IL-2: a matter of life and death for T cells in vivo
    X C Li
    Department of Medicine, Harvard Medical School, Division of Immunology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Nat Med 7:114-8. 2001
    ..Our study provides data that IL-2 and IL-15 regulate distinct aspects of primary T-cell expansion in vivo...
  18. ncbi Overexpression of IL-15 in vivo enhances protection against Mycobacterium bovis bacillus Calmette-Guérin infection via augmentation of NK and T cytotoxic 1 responses
    M Umemura
    Laboratory of Host Defense, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya 466 8550, Japan
    J Immunol 167:946-56. 2001
    ..Thus, overexpression of IL-15 in vivo enhanced protection against BCG infection via augmentation of NK and T cytotoxic 1 responses...
  19. ncbi Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells
    Kimberly S Schluns
    Division of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    J Immunol 168:4827-31. 2002
    ..IL-15Ralpha expression was low on naive CD8 T cells, up-regulated on Ag-specific effector cells, and sustained on memory cells. Thus, IL-15 was important for the generation and the subsequent maintenance of antiviral memory CD8 T cells...
  20. pmc Cytokine requirements for acute and Basal homeostatic proliferation of naive and memory CD8+ T cells
    Ananda W Goldrath
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 195:1515-22. 2002
    ..Our results show that naive and memory T lymphocytes differ in their cytokine dependence for acute homeostatic proliferation and that memory T lymphocytes have distinct requirements for proliferation in full versus empty compartments...
  21. pmc IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells
    Christopher A Klebanoff
    Howard Hughes Medical Institute National Institutes of Health Research Scholars Program, Bethesda, MD 20814, USA
    Proc Natl Acad Sci U S A 101:1969-74. 2004
    ..These results provide several avenues for improving adoptive immunotherapy of cancer in patients...
  22. ncbi Dendritic cells generated in the presence of GM-CSF plus IL-15 prime potent CD8+ Tc1 responses in vivo
    Bali Pulendran
    Emory Vaccine Center, Atlanta, GA 30329, USA
    Eur J Immunol 34:66-73. 2004
    ..Together, these data suggest that IL-15 promotes the development of DC, which induce potent Th1 and Tc1 responses in vivo. This suggests potential roles for these IL-15 DC cells in the immunotherapy of tumors and infectious diseases...
  23. pmc Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function
    Rong Zeng
    Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 201:139-48. 2005
    ..Thus, our studies reveal that IL-21 potently regulates CD8+ T cell expansion and effector function, primarily in a synergistic context with IL-15...
  24. pmc Survival adjustment of mature dendritic cells by IL-15
    Sigrid P Dubois
    Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:8662-7. 2005
    ..These findings support the hypothesis that DCs mediate the effect of IL-15 on CD8+/CD44(hi) memory phenotype T cells...
  25. pmc Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}
    Mark P Rubinstein
    Department of Immunology, IMM4, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:9166-71. 2006
    ..Significantly, the results with IL-2, a soluble cytokine, are quite different; thus, IL-2 function is markedly inhibited by binding to soluble IL-2Ralpha...
  26. doi Unique subset of natural killer cells develops from progenitors in lymph node
    Linnea L Veinotte
    Terry Fox Laboratory, 675 West 10th Ave, Vancouver, British Columbia, Canada V5Z 1L3
    Blood 111:4201-8. 2008
    ..Athymic mice lack the LN NK progenitors expressing CD127 as well as Tcrgamma(+) NK cells. These results suggest that Tcrgamma(+) NK cells may be generated from unique progenitors in the thymus as well as in the LN...
  27. pmc IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation
    Erwan Mortier
    Colitis and Crohn s Disease Center, Gastroenterology Division, Department of Medicine, Biomedical Sciences Program, Program in Biological Sciences, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 205:1213-25. 2008
    ..These studies define an unprecedented cytokine-receptor biosynthetic pathway in which IL-15Ralpha serves as a chaperone for IL-15, after which membrane-bound IL-15Ralpha-IL-15 complexes activate NK cells via direct cell-cell contact...
  28. ncbi Chromosomal assignment and genomic structure of Il15
    D M Anderson
    Immunex Research and Development Corporation, Seattle, Washington 98101, USA
    Genomics 25:701-6. 1995
    ..Murine IL-15 cDNA and genomic clones were isolated and characterized. The murine Il15 gene was found to consist of eight exons spanning at least 34 kb and was localized to the central region of mouse ..
  29. ncbi IL-15, a novel T cell growth factor that shares activities and receptor components with IL-2
    J G Giri
    Immunex Research and Development Corporation, Seattle, WA 98101, USA
    J Leukoc Biol 57:763-6. 1995
    b>Interleukin 15 is a newly discovered cytokine that shares biological activities with IL-2 and, like IL-2, is a member of the four-helix bundle cytokine family...
  30. ncbi IL-15: the role of translational regulation in their expression
    R N Bamford
    Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    J Leukoc Biol 59:476-80. 1996
    ..Thus, IL-15 synthesis by the ATL cell line HuT-102 involves an increase in IL-15 mRNA transcription and translation secondary to the production of an HTLV-I-R fusion message that lacks many upstream AUGs...
  31. ncbi Interleukin-15 preferentially promotes the growth of intestinal intraepithelial lymphocytes bearing gamma delta T cell receptor in mice
    K Inagaki-Ohara
    Laboratory of Host Defense and Germfree Life, Nagoya University School of Medicine, Japan
    Eur J Immunol 27:2885-91. 1997
    ..This rescue was accompanied by up-regulation of Bcl-2 expression. These results suggest that IL-15 plays important roles in proliferation and maintenance of gamma delta i-IEL...
  32. ncbi Translational efficiency is up-regulated by alternative exon in murine IL-15 mRNA
    H Nishimura
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Japan
    J Immunol 160:936-42. 1998
    ..These results suggest that normal IL-15 production in stimulated macrophages is regulated by splicing of alternative exon 5...
  33. pmc Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice
    M K Kennedy
    Immunex Corporation, Seattle, Washington 98101, USA
    J Exp Med 191:771-80. 2000
    C57BL/6 mice genetically deficient in interleukin 15 (IL-15(-/-) mice) were generated by gene targeting...
  34. ncbi A protective role of interleukin-15 in a mouse model for systemic infection with herpes simplex virus
    H Tsunobuchi
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya, Japan
    Virology 275:57-66. 2000
    ..Taken together, these results suggest that IL-15, using the IL-2/IL15R beta chain, plays an important role in mounting protective immunity during the course of systemic HSV-2 infection...
  35. ncbi IL-15 is expressed by dendritic cells in response to type I IFN, double-stranded RNA, or lipopolysaccharide and promotes dendritic cell activation
    F Mattei
    Laboratory of Virology, Istituto Superiore di Sanita, Rome, Italy
    J Immunol 167:1179-87. 2001
    ..These results identify IL-15 as a stimulatory cytokine for DCs with the potential for autocrine activity and link its effects to expression of IFN-alphabeta...
  36. ncbi Critical role of IL-15-IL-15R for antigen-presenting cell functions in the innate immune response
    T Ohteki
    Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Nat Immunol 2:1138-43. 2001
    ..This shows that the IL-15-IL-15R interaction is critical in early activation of antigen-presenting cells and plays an important role in the innate immune system...
  37. ncbi Overexpression of IL-15 in vivo increases antigen-driven memory CD8+ T cells following a microbe exposure
    Toshiki Yajima
    Laboratory of Host Defense, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya 466 8550, Japan
    J Immunol 168:1198-203. 2002
    ..These results suggest that IL-15 plays an important role in long-term maintenance of Ag-specific memory CD8+ T cells following microbial exposure via promotion of cell survival and homeostatic proliferation...
  38. pmc IL-15, a survival factor for kidney epithelial cells, counteracts apoptosis and inflammation during nephritis
    Michiya Shinozaki
    Laboratory of Molecular Autoimmune Disease, Renal Division, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Clin Invest 109:951-60. 2002
    ..Taken together, we suggest that IL-15 is a therapeutic for tubulointerstitial and glomerular kidney diseases...
  39. pmc Treatment with soluble interleukin-15Ralpha exacerbates intracellular parasitic infection by blocking the development of memory CD8+ T cell response
    Imtiaz A Khan
    Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Science Center, New Orleans, LA 70112, USA
    J Exp Med 195:1463-70. 2002
    ..gondii challenge. To our knowledge, this is the first demonstration of the important role of host IL-15 in the development of antigen-specific memory CD8+ T cells against an intracellular infection...
  40. pmc Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells
    Joyce T Tan
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 195:1523-32. 2002
    ..Thus, the homeostatic proliferation mechanisms that control memory CD8+ cells and memory CD4+ cells are quite distinct...
  41. pmc Overexpression of interleukin (IL)-7 leads to IL-15-independent generation of memory phenotype CD8+ T cells
    William C Kieper
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 195:1533-9. 2002
    ..Since these cell are rare in normal IL-15(-) mice, the dependency of memory phenotype CD8+ cells on IL-15 can be overcome by overexpression of IL-7...
  42. pmc Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells
    Todd C Becker
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Exp Med 195:1541-8. 2002
    ..Taken together, these results show that IL-15 is not essential for the generation of memory CD8 T cells, but is required for homeostatic proliferation to maintain populations of memory cells over long periods of time...
  43. ncbi Homeostasis of V alpha 14i NKT cells
    Jennifer L Matsuda
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA
    Nat Immunol 3:966-74. 2002
    ....
  44. ncbi Coordinated and distinct roles for IFN-alpha beta, IL-12, and IL-15 regulation of NK cell responses to viral infection
    Khuong B Nguyen
    Deparment of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA
    J Immunol 169:4279-87. 2002
    ....
  45. ncbi In vivo evidence for a dependence on interleukin 15 for survival of natural killer cells
    Megan A Cooper
    Department of Internal Medicine, Division of Hematology Oncology, The James Cancer Hospital and Comprehensive Cancer Center, The Ohio State University, Columbus 43210, USA
    Blood 100:3633-8. 2002
    ..Production of natural killer (NK) cells from bone marrow precursor cells requires interleukin 15 (IL-15); however, very little is known about the factors controlling survival of mature NK cells in vivo...
  46. ncbi IL-15 is an essential mediator of peripheral NK-cell homeostasis
    Thomas Ranson
    Unité des Cytokines et Développement Lymphoide, Institut Pasteur, Paris, France
    Blood 101:4887-93. 2003
    ..Finally, although NK cells bear functional inhibitory Ly49 receptors for MHC class I molecules, the presence or absence of specific ligands on host cells did not influence the survival or homeostatic expansion of donor NK cells...
  47. pmc IL-15 availability conditions homeostasis of peripheral natural killer T cells
    Thomas Ranson
    Unité des Cytokines et Développement Lymphoide Institut National de la Santé et de la Recherche Médicale Equipe 101, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris, France
    Proc Natl Acad Sci U S A 100:2663-8. 2003
    ..In contrast, TCR "tickling" of NK-T cells, if it occurs under steady-state conditions, does not by itself provide a sufficient signal for their peripheral survival...
  48. ncbi Production of interleukin 15 by human colon cancer cells is associated with induction of mucosal hyperplasia, angiogenesis, and metastasis
    Hiroki Kuniyasu
    Department of Oncological Pathology, Nara Medical University Cancer Center, Kashihara, Nara 634 8521, Japan
    Clin Cancer Res 9:4802-10. 2003
    ..The purpose of this study was to identify a mediator produced by human colon cancer cells that is responsible for the induction of hyperplasia in the adjacent mucosa...
  49. pmc IL-7 regulates basal homeostatic proliferation of antiviral CD4+T cell memory
    Derek C Lenz
    Departments of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 101:9357-62. 2004
    ..We propose that homeostatic control of antiviral CD4(+) and CD8(+) T cell memory is fundamentally similar and characterized by quantitative, rather than qualitative, differences...
  50. ncbi Roles for common cytokine receptor gamma-chain-dependent cytokines in the generation, differentiation, and maturation of NK cell precursors and peripheral NK cells in vivo
    Christian A J Vosshenrich
    Unité des Cytokines et Développement Lymphoide, Institut Nationale de la Santé et Recherche Médicale Equipe 101, Institut Pasteur, Paris, France
    J Immunol 174:1213-21. 2005
    ..Surprisingly, the few residual NK cells generated in absence of IL-15 appear relatively mature, expressing a variety of Ly49 receptors and demonstrating lytic and cytokine production capacity...
  51. ncbi Interleukin-15 stimulates adiponectin secretion by 3T3-L1 adipocytes: evidence for a skeletal muscle-to-fat signaling pathway
    LeBris S Quinn
    Geriatric Research, Education, and Clinical Center, 151 American Lake Division, VA Puget Sound Health Care System, Tacoma, WA 98493, USA
    Cell Biol Int 29:449-57. 2005
    ..These findings provide support for the hypothesis that IL-15 functions in a muscle-to-fat endocrine axis which modulates fat:lean body composition and insulin sensitivity...
  52. pmc Role of interleukin 15 in colitis induced by dextran sulphate sodium in mice
    K Yoshihara
    Division of Host Defence, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Gut 55:334-41. 2006
    ..IL-15 levels were elevated in the intestinal mucosa of inflammatory bowel diseases. Here we investigated the involvement of IL-15 in the pathogenesis of acute and chronic dextran sulphate sodium (DSS) induced colitis...
  53. ncbi IL-15 regulates CD8+ T cell contraction during primary infection
    Toshiki Yajima
    Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Immunol 176:507-15. 2006
    ..These results suggest that IL-15 plays a critical role in protecting effector CD8+ T cells from apoptosis during the contraction phase following a microbial infection via inducing antiapoptotic molecules...
  54. ncbi Interleukin-15 increases hepatic regenerative activity
    Ayako Suzuki
    Division of Gastroenterology and Department of Medicine, Duke University Medical Center, Durham, NC, USA
    J Hepatol 45:410-8. 2006
    ..It generally inhibits apoptosis and increases cellular proliferation and differentiation. However, IL-15's roles in liver are unknown. We aimed to determine if IL-15 influences hepatic integrity and regenerative activity...
  55. pmc Dysregulation of IL-15-mediated T-cell homeostasis in TGF-beta dominant-negative receptor transgenic mice
    Philip J Lucas
    Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, CRC 3 3288, 10 Center Drive, Bethesda, MD 20892, USA
    Blood 108:2789-95. 2006
    ..These data establish TGF-beta as a critical and dominant tumor-suppressor pathway opposing IL-15-mediated CD8+ T-cell expansion and potential malignant transformation...
  56. pmc Essential roles of DC-derived IL-15 as a mediator of inflammatory responses in vivo
    Toshiaki Ohteki
    Department of Immunology, Akita University School of Medicine, Akita 010 8543, Japan
    J Exp Med 203:2329-38. 2006
    ..Collectively, these data indicate the importance of DC-derived IL-15 as a mediator of inflammatory responses in vivo...
  57. ncbi Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms
    Ming O Li
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 25:455-71. 2006
    ..This study reveals pleiotropic functions of TGF-beta signaling in T cells that may ensure a diverse and self-tolerant T cell repertoire in vivo...
  58. pmc Dendritic cells prime natural killer cells by trans-presenting interleukin 15
    Mathias Lucas
    Skirball Institute of Biomolecular Medicine, Program in Molecular Pathogenesis, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Immunity 26:503-17. 2007
    ..Our data define a unique in vivo role of DCs for the priming of NK cells, revealing a striking and previously unappreciated homology to T lymphocytes of the adaptive immune system...
  59. pmc IL-15 and IL-15R alpha gene deletion: effects on T lymphocyte trafficking and the microglial and neuronal responses to facial nerve axotomy
    Zhi Huang
    McKnight Brain Institute, University of Florida, Gainesville, FL 32608, USA
    Neurosci Lett 417:160-4. 2007
    ..Further studies are needed to dissect the mechanisms that underlie these observations (e.g., central vs. peripheral immune contributions)...
  60. pmc Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor
    Nikhil S Joshi
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 27:281-95. 2007
    ..These results elucidate a mechanism by which the innate immune system sets the relative amounts of a lineage-determining transcription factor in activated CD8(+) T cells and, correspondingly, regulates their memory cell potential...
  61. ncbi The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways
    Daniela de Totero
    Department of Translational Oncology and Medical Oncology C, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Blood 111:517-24. 2008
    ..The knowledge of the signaling pathways regulating CLL cell survival and proliferation may provide new molecular targets for therapeutic intervention...
  62. pmc IL-15 as a mediator of CD4+ help for CD8+ T cell longevity and avoidance of TRAIL-mediated apoptosis
    SangKon Oh
    Vaccine Branch and Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1578, USA
    Proc Natl Acad Sci U S A 105:5201-6. 2008
    ..These findings suggest new vaccine strategies against infections and cancers, especially in individuals with CD4-deficiency...
  63. pmc A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells
    Allison L Bayer
    Department of Microbiology and Immunology, Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    J Immunol 181:225-34. 2008
    ..Collectively, these data indicate that IL-7R signaling contributes to Treg cell development and peripheral homeostasis...
  64. doi Association between interleukin-15 and obesity: interleukin-15 as a potential regulator of fat mass
    Anders Rinnov Nielsen
    Department of Infectious Diseases Rigshospitalet, Centre of Inflammation and Metabolism, University of Copenhagen, Section 7641, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    J Clin Endocrinol Metab 93:4486-93. 2008
    ..IL-15 is expressed in human skeletal muscle and skeletal muscle may be a source of plasma IL-15 and in this way regulate adipose tissue mass...
  65. pmc Dendritic cells drive memory CD8 T-cell homeostasis via IL-15 transpresentation
    Spencer W Stonier
    Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Blood 112:4546-54. 2008
    ..The identification of DCs fulfilling this role will enable future studies to better focus on mechanisms regulating T-cell homeostasis...
  66. pmc Dendritic cell and NK cell reciprocal cross talk promotes gamma interferon-dependent immunity to blood-stage Plasmodium chabaudi AS infection in mice
    Rebecca Ing
    Centre for the Study of Host Resistance, Research Institute of the McGill University Health Centre, 1650 Cedar Avenue, Montreal, Quebec, H3G 1A4, Canada
    Infect Immun 77:770-82. 2009
    ..the uptake of iRBC by splenic CD11c(+) DCs in resistant wild-type (WT) C57BL/6 mice was similar to that in interleukin 15(-/-) (IL-15(-/-)) and IL-12p40(-/-) mice, which differ in the severity of P. chabaudi AS infection...
  67. doi Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense
    Naoko Satoh-Takayama
    Cytokines and Lymphoid Development Unit, Institut Pasteur, Paris F 75724, France
    Immunity 29:958-70. 2008
    ..RORgammat-driven diversification of intestinal NKp46+ cells thereby specifies an innate cellular defense mechanism that operates at mucosal surfaces...
  68. pmc Opposing effects of TGF-beta and IL-15 cytokines control the number of short-lived effector CD8+ T cells
    Shomyseh Sanjabi
    Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 31:131-44. 2009
    ....
  69. pmc Cutting edge: IL-15-independent NK cell response to mouse cytomegalovirus infection
    Joseph C Sun
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143 0414, USA
    J Immunol 183:2911-4. 2009
    ..Together, these findings demonstrate a previously unrecognized independence of NK cells on IL-15 or other common gamma signaling cytokines during their response against viral infection...
  70. doi Effects of interleukin-15 on neuronal differentiation of neural stem cells
    Yuahn Sieh Huang
    Department of Anatomy, Faculty of Medicine, Chung Shan Medical University, Taichung, Taiwan
    Brain Res 1304:38-48. 2009
    ..This signal transduction modifies MAP-2 protein levels and, consequently, the differentiation of neurons from NSCs, as evidenced by reduced neurite outgrowth...
  71. pmc Transcriptional regulation of mouse mast cell protease-2 by interleukin-15
    Farhad Mirghomizadeh
    Division of Immunobiology, Department of Immunology and Cell Biology, Research Center Borstel, 23845 Borstel, Germany
    J Biol Chem 284:32635-41. 2009
    ..This suggests a novel model of cytokine-controlled protease transcription: non-CpG methylation maintains a chromosomal domain in an "open" configuration that is permissive for gene expression...
  72. doi Role of interleukin-15 in the development of mouse olfactory nerve
    Tsuyoshi Umehara
    Department of Otorhinolaryngology, Faculty of Medicine, Shimane University, Izumo, Japan
    Congenit Anom (Kyoto) 49:253-7. 2009
    ..Adult IL-15R alpha knockout mice had fewer mature olfactory neurons and proliferating cells than wild-type. Our results suggest that IL-15 plays an important role in regulating cell proliferation in olfactory neurogenesis...
  73. doi Aggravated experimental autoimmune encephalomyelitis in IL-15 knockout mice
    Diego Gómez-Nicola
    Neural Plasticity Group, Functional and Systems Neurobiology Department, Instituto Cajal, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    Exp Neurol 222:235-42. 2010
    ..How these findings are contributing to the aggravated EAE development in IL-15 KO mice remain unclear and need to be further investigated...
  74. pmc Interleukin-15 and its receptor augment dendritic cell vaccination against the neu oncogene through the induction of antibodies partially independent of CD4 help
    Jason C Steel
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892 1374, USA
    Cancer Res 70:1072-81. 2010
    ..Coexpression of IL-15 and IL-15Ralpha in an anticancer vaccine enhanced immune responses against the NEU antigen and may overcome impaired CD4(+) T-helper function...
  75. doi c-Myc controls the development of CD8alphaalpha TCRalphabeta intestinal intraepithelial lymphocytes from thymic precursors by regulating IL-15-dependent survival
    Wei Jiang
    Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland
    Blood 115:4431-8. 2010
    ..Taken together, our data support a model in which c-Myc controls the development of CD8alphaalpha TCRalphabeta IELs from thymic precursors by regulating interleukin-15 receptor expression and consequently Bcl-2-dependent survival...
  76. pmc Distinct roles for IL-2 and IL-15 in the differentiation and survival of CD8+ effector and memory T cells
    Diana M Mitchell
    Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA
    J Immunol 184:6719-30. 2010
    ..These findings indicate a unique role for IL-2, but not IL-15, in promoting the differentiation not only of primary effector CD8+ T cells, but also of CD8+ memory T cells capable of secondary effector differentiation...
  77. pmc A role for IL-15 in the migration of effector CD8 T cells to the lung airways following influenza infection
    Katherine C Verbist
    Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA
    J Immunol 186:174-82. 2011
    ....
  78. pmc Development of an IL-15-autocrine CD8 T-cell leukemia in IL-15-transgenic mice requires the cis expression of IL-15Rα
    Noriko Sato
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Blood 117:4032-40. 2011
    ....
  79. doi Interleukin-15 affects differentiation and apoptosis in adipocytes: implications in obesity
    Gemma Fuster
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Cancer Research Group, Universitat de Barcelona, Diagonal 645, 08028, Barcelona, Spain
    Lipids 46:1033-42. 2011
    ..Altogether, the results presented here reinforce the idea that IL-15 is an important mediator that regulates adipose size and, therefore, the role of the cytokine in affecting body weight and obesity deserves additional studies...
  80. pmc IL-15 regulates homeostasis and terminal maturation of NKT cells
    Laura E Gordy
    Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Immunol 187:6335-45. 2011
    ..Taken together, our findings reveal a critical role for IL-15 in NKT cell survival, which is mediated by Bcl-x(L), and effector differentiation, which is consistent with a role of T-bet in regulating terminal maturation...
  81. pmc Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development
    Gerritje J W van der Windt
    Trudeau Institute, Saranac Lake, NY 12983, USA
    Immunity 36:68-78. 2012
    ..These results show how cytokines control the bioenergetic stability of memory T cells after infection by regulating mitochondrial metabolism...
  82. pmc Circulating IL-15 exists as heterodimeric complex with soluble IL-15Rα in human and mouse serum
    Cristina Bergamaschi
    Human Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Blood 120:e1-8. 2012
    ..Analysis of the form of IL-15 present in either normal or lymphodepleted mice agrees with the human data. These results have important implications for development of assays and materials for clinical applications of IL-15...
  83. doi Interleukin-15-dependent NKp46+ innate lymphoid cells control intestinal inflammation by recruiting inflammatory monocytes
    Julie Schulthess
    INSERM, U989, 75015 Paris, France Université Paris Descartes, Paris Sorbonne Cité, Institut Imagine, France
    Immunity 37:108-21. 2012
    ..Preliminary evidence suggests that this pathway might operate in Crohn's disease...
  84. pmc Transcriptional regulation of IL-15 expression during hematopoiesis
    Sara L Colpitts
    Department of Immunology, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Immunol 191:3017-24. 2013
    ..Thus, IL-15 expression is coordinated with cellular fate in myeloid versus lymphoid immune cells...
  85. ncbi IL-15-dependent activation-induced cell death-resistant Th1 type CD8 alpha beta+NK1.1+ T cells for the development of small intestinal inflammation
    Noriyuki Ohta
    Department of Mucosal Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    J Immunol 169:460-8. 2002
    ..The model may contribute to understanding the role of CD8(+) T cells in human Crohn's disease involving the SI...
  86. pmc ITK and IL-15 support two distinct subsets of CD8+ T cells
    Sigrid Dubois
    Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:12075-80. 2006
    ..Thus, whereas ITK-dependent CD44(lo)CD122(lo) CD8(+) T cells appear to represent conventional CD8(+) T cells, IL-15-dependent CD44(hi)CD122(hi) CD8(+) T cells may have functions in both adaptive and innate immunity...
  87. pmc Antiviral CD4+ memory T cells are IL-15 dependent
    Jared F Purton
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 204:951-61. 2007
    ..Therefore, under normal physiological conditions, homeostasis of CD8(+) and CD4(+) memory cells is quite similar and involves IL-15 and IL-7...
  88. ncbi IL-15 is required for sustained lymphopenia-driven proliferation and accumulation of CD8 T cells
    Michelle M Sandau
    Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    J Immunol 179:120-5. 2007
    ..These findings demonstrate that cytokine requirements for LIP change during the process itself, illustrating the need to identify factors that regulate successive stages of lymphopenia-driven proliferation...
  89. ncbi Studies evaluating the antitumor activity and toxicity of interleukin-15, a new T cell growth factor: comparison with interleukin-2
    W Munger
    Immunex Research and Development Corporation, Seattle, Washington 98101, USA
    Cell Immunol 165:289-93. 1995
    ..These results support the view that interleukin-15 exhibits a therapeutic index that is superior to interleukin-2...
  90. ncbi Dendritic cell-derived IL-15 controls the induction of CD8 T cell immune responses
    Rene Rückert
    Research Center Borstel, Department of Immunology and Cell Biology, Borstel, Germany
    Eur J Immunol 33:3493-503. 2003
    ..Therefore, targeted manipulation of this loop promises to be an effective, novel strategy for therapeutic modulation of clinically relevant DTH reactions...
  91. ncbi Developmental and functional defects of thymic and epidermal V gamma 3 cells in IL-15-deficient and IFN regulatory factor-1-deficient mice
    An De Creus
    Department of Clinical Chemistry, Microbiology, and Immunology, University of Ghent, University Hospital, Ghent, Belgium
    J Immunol 168:6486-93. 2002
    ..Furthermore, a possible role for IRF-1 in inducing morphological maturation of DETCs and cytolytic capacity of V gamma 3 cells is suggested...
  92. ncbi Assessment of requirements for IL-15 and IFN regulatory factors in uterine NK cell differentiation and function during pregnancy
    Ali A Ashkar
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Immunol 171:2937-44. 2003
    ..These studies indicate that uNK cell development and maturation share some aspects with NK cell development in other tissues, but also display distinctive tissue-specific regulation...
  93. ncbi Lack of the mediators of innate immunity attenuate the development of autoimmune diabetes in mice
    M L Lukic
    Department of Microbiology and Immunology, Faculty of Medicine and Health Sciences, UAE University, PO Box 17666, Al Ain, United Arab Emirates
    J Autoimmun 21:239-46. 2003
    b>Interleukin 15 (IL-15) and Interleukin 18 (IL-18) are key cytokines produced by macrophages during innate immune response. These cytokines can profoundly affect subsequent adaptive immune responses including autoimmunity...
  94. ncbi STAT5 is required for thymopoiesis in a development stage-specific manner
    Joonsoo Kang
    Department of Pathology, Graduate Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 173:2307-14. 2004
    ....
  95. pmc NK and NKT cell-independent contribution of interleukin-15 to innate protection against mucosal viral infection
    Navkiran Gill
    Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada
    J Virol 79:4470-8. 2005
    ..The results of these studies indicate that IL-15 can act independently of NK/NKT cells in mediating the innate defense against viral infection...
  96. ncbi Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factors
    Roberto Baccala
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 174:4606-12. 2005
    ..Thus, gamma delta T cell homeostasis is maintained by trophic cytokines commonly used by other types of lymphoid cells, as well as by additional, as yet unidentified, gamma delta-specific factors...
  97. ncbi Constitutive activation of STAT5 supersedes the requirement for cytokine and TCR engagement of CD4+ T cells in steady-state homeostasis
    Devon K Taylor
    Department of Medicine, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    J Immunol 177:2216-23. 2006
    ..This suggests that the need for TCR stimulation to induce common gamma-chain cytokine receptor expression, and thus STAT5 activation, is a key factor in maintaining normal CD4+ T cell homeostasis...
  98. doi Immunological mechanisms and clinical implications of regulatory T cell deficiency in a systemic autoimmune disorder: roles of IL-2 versus IL-15
    Cui Hong Yang
    Department of Pathology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
    Eur J Immunol 38:1664-76. 2008
    ..These findings thus provide a clear causal relationship and immunological mechanism underlying Treg deficiency and systemic autoimmunity...
  99. pmc IL-15 trans-presentation by pulmonary dendritic cells promotes effector CD8 T cell survival during influenza virus infection
    Jodi McGill
    Department of Pathology, Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52241, USA
    J Exp Med 207:521-34. 2010
    ....
  100. pmc Early signals during CD8 T cell priming regulate the generation of central memory cells
    Joshua J Obar
    Department of Immunology, Center for Integrated Immunology and Vaccine Research, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Immunol 185:263-72. 2010
    ..These observations identify key early signals that help establish the T(CM)/T(EM) cell dichotomy and provide the means to manipulate memory lineage choices...
  101. pmc Thymic and peripheral microenvironments differentially mediate development and maturation of iNKT cells by IL-15 transpresentation
    Eliseo F Castillo
    Department of Immunology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 116:2494-503. 2010
    ..Overall, these studies identify stage-specific functions of IL-15, which are determined by the tissue microenvironment and elucidate the importance of IL-15 in functional maturation...

Research Grants18

  1. THERAPY FOR AIDS CENTRAL NERVOUS SYSTEM LYMPHOMA
    Michael Caligiuri; Fiscal Year: 2002
    ..The limitations of the animal model preclude its use for studying the pathogenesis of AIDS PCNSL. ..
  2. Mechanisms of CTLA-4 Function
    Joonsoo Kang; Fiscal Year: 2007
    ..Understanding these processes is critical for designing novel therapeutic approaches for vaccine development, autoimmune disease, and in transplant and tumor immunology. ..
  3. Regulation of T cell development by SOX13
    Joonsoo Kang; Fiscal Year: 2009
    ..Collectively, the genetic program controlling T cell lineage commitment and maturation will be determined, allowing a better understanding of leukemogenesis. ..
  4. POLARIZING T CELL RESPONSES IN VIVO WITH DENDRITIC CELLS
    Bali Pulendran; Fiscal Year: 2010
    ..The focus of the present proposal is to understand how this signaling pathway in DCs, regulates inflammation, immunological tolerance and vaccine induced immunity. ..
  5. IL-15, Body Compositition and Insulin Sensivity in Aging
    LeBris S Quinn; Fiscal Year: 2010
    ..abstract_text> ..
  6. Transport of TNFalpha across the BBB
    Weihong Pan; Fiscal Year: 2008
    ..These transporters could be novel drug targets and therefore provide promising therapeutic potential. [unreadable] [unreadable]..
  7. Transport of neurotrophic cytokines after spinal cord injury
    Weihong Pan; Fiscal Year: 2007
    ..Understanding the mechanisms of cytokine transport at this regulatory interface would help in the design of new approaches to treat SCI. ..
  8. The immune response to latent gammaherpesvirus antigens
    Edward Usherwood; Fiscal Year: 2003
    ..In addition they will increase our knowledge of the host-virus interaction during latent/chronic viral infections in general. ..
  9. The regulation of tumor immunity by NKT cells
    Mark Smyth; Fiscal Year: 2007
    ..This proposal focuses clearly on a pivotal immune control mechanism that will influence many current and future immunotherapies. ..
  10. MODULATING HIV-IMMUNITY WITH DENDRITIC CELLS
    Bali Pulendran; Fiscal Year: 2004
    ..If successful, such a strategy will likely greatly advance the design of effective vaccines against HIV/AIDS in humans in the future. ..
  11. Conceptus-Dependent Effects on the Endometrium
    Brent Bany; Fiscal Year: 2009
    ....
  12. Determination of Mechanism of T cell Lineage Committment
    Joonsoo Kang; Fiscal Year: 2006
    ..The long-term objective of this application is to identify genes that determine T cell lineage fate. ..
  13. MICROBES, DENDRITIC CELL SUBSETS AND T-CELL IMMUNITY
    Bali Pulendran; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  14. ANTHRAX TOXIN, DENDRITIC CELLS AND ADAPTIVE IMMUNITY
    Bali Pulendran; Fiscal Year: 2006
    ....
  15. The function of membrane vesiculation in CTLA-4-mediate*
    Joonsoo Kang; Fiscal Year: 2005
    ..To date there has been limited advancement on the ability to increase CTLA-4 function. The proposed model of CTLA-4 function would provide a novel means to increase CTLA-4-mediated inhibition in vivo. ..
  16. Anti-Tumor Autoimmunity by lymphopenia T cell Expansion
    Roberto Baccala; Fiscal Year: 2008
    ..The results will define the role of homeostatic T cell proliferation in tumor autoimmunity, and provide new approaches to the treatment of cancer. [unreadable] [unreadable]..
  17. Elucidating the Mechanisms of Function of the Transcriptional Regulator Aire
    Tiffany Horng; Fiscal Year: 2008
    ..This system will also enable us to map the region of the promoter necessary for Aire-dependent activity, and identify a minimal Aire-responsive element. [unreadable] [unreadable] [unreadable]..
  18. MICROBES, DENDRITIC CELL SUBSETS AND T-CELL IMMUNITY
    Bali Pulendran; Fiscal Year: 2008
    ..abstract_text> ..