Il13

Summary

Gene Symbol: Il13
Description: interleukin 13
Alias: Il-13, interleukin-13, T-cell activation protein P600
Species: mouse

Top Publications

  1. ncbi Modulation of murine macrophage function by IL-13
    T M Doherty
    Department of Immunology, DNAX Research Institute for Cellular and Molecular Biology, Palo Alto, CA 94304
    J Immunol 151:7151-60. 1993
  2. pmc An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response
    M G Chiaramonte
    Schistosomiasis Immunology and Pathology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 104:777-85. 1999
  3. ncbi Integrated signals between IL-13, IL-4, and IL-5 regulate airways hyperreactivity
    D C Webb
    Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra
    J Immunol 165:108-13. 2000
  4. ncbi IL-9-deficient mice establish fundamental roles for IL-9 in pulmonary mastocytosis and goblet cell hyperplasia but not T cell development
    J M Townsend
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Immunity 13:573-83. 2000
  5. ncbi IL-13 gene-deficient mice are susceptible to cutaneous L. mexicana infection
    M R Sosa
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, USA
    Eur J Immunol 31:3255-60. 2001
  6. ncbi Structural comparison and chromosomal localization of the human and mouse IL-13 genes
    A N McKenzie
    Department of Molecular Biology, DNAX Research Institute of Cellular and Molecular Biology, Palo Alto, CA 94304
    J Immunol 150:5436-44. 1993
  7. ncbi Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice
    K Takeda
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    J Immunol 157:3220-2. 1996
  8. ncbi A critical role for IL-13 in resistance to intestinal nematode infection
    A J Bancroft
    School of Biological Science, University of Manchester, United Kingdom
    J Immunol 160:3453-61. 1998
  9. ncbi Differences between IL-4R alpha-deficient and IL-4-deficient mice reveal a role for IL-13 in the regulation of Th2 responses
    M Barner
    Basel Institute for Immunology, Switzerland
    Curr Biol 8:669-72. 1998
  10. ncbi Impaired development of Th2 cells in IL-13-deficient mice
    G J McKenzie
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Immunity 9:423-32. 1998

Scientific Experts

Detail Information

Publications124 found, 100 shown here

  1. ncbi Modulation of murine macrophage function by IL-13
    T M Doherty
    Department of Immunology, DNAX Research Institute for Cellular and Molecular Biology, Palo Alto, CA 94304
    J Immunol 151:7151-60. 1993
    ..These data indicate that IL-13 could be a potent modulator of immune responses in vivo, with effects that may embrace both macrophage suppressive and macrophage potentiating functions...
  2. pmc An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response
    M G Chiaramonte
    Schistosomiasis Immunology and Pathology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 104:777-85. 1999
    ..Thus, our findings provide evidence that IL-13 inhibitors may be of general therapeutic benefit in preventing damaging tissue fibrosis resulting from Th2-dominated inflammatory responses...
  3. ncbi Integrated signals between IL-13, IL-4, and IL-5 regulate airways hyperreactivity
    D C Webb
    Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra
    J Immunol 165:108-13. 2000
    ..Taken together, our data suggest both a modulatory role for IL-13 during sensitization and a proinflammatory role during aeroallergen challenge. The latter process appears redundant with respect to IL-4...
  4. ncbi IL-9-deficient mice establish fundamental roles for IL-9 in pulmonary mastocytosis and goblet cell hyperplasia but not T cell development
    J M Townsend
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Immunity 13:573-83. 2000
    ..Thus, deletion of IL-9 manifests as a highly defined phenotype in Th2 responses modulating mucus production and mast cell proliferation...
  5. ncbi IL-13 gene-deficient mice are susceptible to cutaneous L. mexicana infection
    M R Sosa
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, USA
    Eur J Immunol 31:3255-60. 2001
    ..These findings demonstrate that IL-13 is not involved in mediating susceptibility to L. mexicana. Moreover, they also indicate that IL-4 not IL-13 is a dominant cytokine involved in pathogenesis of cutaneous L. mexicana infection...
  6. ncbi Structural comparison and chromosomal localization of the human and mouse IL-13 genes
    A N McKenzie
    Department of Molecular Biology, DNAX Research Institute of Cellular and Molecular Biology, Palo Alto, CA 94304
    J Immunol 150:5436-44. 1993
    ..The nucleotide sequence of a 4.6-kb DNA segment of the human gene is described. The human IL-13 gene (IL13) occurs as a single copy in the haploid genome and maps to human chromosome 5. A 4...
  7. ncbi Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice
    K Takeda
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    J Immunol 157:3220-2. 1996
    ..Taken together, these results suggest that the macrophage functions in response to IL-13 were impaired in STAT6-deficient mice, indicating that IL-13 and IL-4 share the signaling pathway via STAT6...
  8. ncbi A critical role for IL-13 in resistance to intestinal nematode infection
    A J Bancroft
    School of Biological Science, University of Manchester, United Kingdom
    J Immunol 160:3453-61. 1998
    ..The IL-13 KO mouse had a separate phenotype to that of the IL-4 KO mouse, suggesting that both IL-4 and IL-13 play important yet different roles in mediating immunity to intestinal helminths...
  9. ncbi Differences between IL-4R alpha-deficient and IL-4-deficient mice reveal a role for IL-13 in the regulation of Th2 responses
    M Barner
    Basel Institute for Immunology, Switzerland
    Curr Biol 8:669-72. 1998
    ..Injection of recombinant IL-13 induced worm expulsion in otherwise incompetent RAG2-/- mice. Our results suggest that IL-13 regulates Th2 responses to nematode infection and requires IL-4R alpha...
  10. ncbi Impaired development of Th2 cells in IL-13-deficient mice
    G J McKenzie
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Immunity 9:423-32. 1998
    ..Thus, IL-13 is an important regulator of Th2 commitment and may therefore play a central role in atopy and infectious diseases...
  11. ncbi IL-13 is a key regulatory cytokine for Th2 cell-mediated pulmonary granuloma formation and IgE responses induced by Schistosoma mansoni eggs
    M G Chiaramonte
    Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 0425, USA
    J Immunol 162:920-30. 1999
    ..Together, these data demonstrate that IL-13 serves as an important mediator of Th2-mediated inflammation and plays a role in eliciting IgE responses triggered by schistosome eggs...
  12. pmc Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
    Z Zhu
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8057, USA
    J Clin Invest 103:779-88. 1999
    ..IL-13 may play an important role in the pathogenesis of similar responses in asthma or other Th2-polarized tissue responses...
  13. ncbi Differences between IL-4- and IL-4 receptor alpha-deficient mice in chronic leishmaniasis reveal a protective role for IL-13 receptor signaling
    M Mohrs
    Max Planck Institute for Immunobiology, Freiburg, Germany
    J Immunol 162:7302-8. 1999
    ..major, mediated by a functional IL-13 receptor...
  14. ncbi IL-13 is a susceptibility factor for Leishmania major infection
    D J Matthews
    Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    J Immunol 164:1458-62. 2000
    ..Furthermore, using BALB/c mice deficient in the expression of IL-4, IL-13, or both IL-13 and IL-4, we demonstrate that IL-13-deficient mice are resistant to infection and that there is an additive effect of deleting both IL-4 and IL-13...
  15. ncbi Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agent
    P G Fallon
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom and Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    J Immunol 164:2585-91. 2000
    ..Therefore, we demonstrate that during a dynamic type 2 cytokine disease process IL-13 is detrimental to survival following infection, whereas IL-4 is beneficial...
  16. pmc Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema
    T Zheng
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8057, USA
    J Clin Invest 106:1081-93. 2000
    ..They also demonstrate that IL-13 causes emphysema via a MMP- and cathepsin-dependent mechanism(s) and highlight common mechanisms that may underlie COPD and asthma...
  17. ncbi IL-13 overexpression predisposes to anaphylaxis following antigen sensitization
    P G Fallon
    Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    J Immunol 166:2712-6. 2001
    ..The systemic regulation of this response makes these mice an important resource for studying atopic responses...
  18. ncbi IL-13 induces airways hyperreactivity independently of the IL-4R alpha chain in the allergic lung
    J Mattes
    Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
    J Immunol 167:1683-92. 2001
    ..We show that this novel pathway for IL-13 signaling is dependent on T cell activation in the lung and is critically linked to downstream effector pathways regulated by eotaxin and STAT6...
  19. ncbi Critical role for IL-13 in the development of allergen-induced airway hyperreactivity
    D M Walter
    Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, CA 94305, USA
    J Immunol 167:4668-75. 2001
    ..Therefore, treatment of human asthma with antagonists of IL-13 may be very effective...
  20. ncbi Interleukin-13 mediates airways hyperreactivity through the IL-4 receptor-alpha chain and STAT-6 independently of IL-5 and eotaxin
    M Yang
    Division of Biochemistry and Molecular Biology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
    Am J Respir Cell Mol Biol 25:522-30. 2001
    ..Furthermore, IL-13-induced AHR, eosinophilia, and mucus production are critically dependent on the IL-4Ralpha chain and STAT-6...
  21. ncbi Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism
    M Hesse
    Schistosomiasis Immunology and Pathology Unit and Max Planck Institut für Immunbiologie, Freiburg, Germany
    J Immunol 167:6533-44. 2001
    ....
  22. ncbi Interleukin 18 (IL-18) in synergy with IL-2 induces lethal lung injury in mice: a potential role for cytokines, chemokines, and natural killer cells in the pathogenesis of interstitial pneumonia
    Masaki Okamoto
    Department of Internal Medicine, Kurume University School of Medicine, Japan
    Blood 99:1289-98. 2002
    ..These results suggest that the clinical use of this interleukin may result in unexpected physiological consequences...
  23. ncbi IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13
    Padraic G Fallon
    Immunomodulation Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Immunity 17:7-17. 2002
    ..These mice reveal distinct spatial, temporal, and hierarchical cytokine requirements in immune function...
  24. ncbi Th2 activities induced during virgin T cell priming in the absence of IL-4, IL-13, and B cells
    Adam F Cunningham
    University of Birmingham, Medical Research Council Centre for Immune Regulation, Birmingham, United Kingdom
    J Immunol 169:2900-6. 2002
    ..These early events that direct virgin T cells toward Th2 differentiation contrast with the critical later role of Th2 cytokines in selectively expanding Th2 clones and driving further IL-4 synthesis...
  25. ncbi The role of IL-13 in established allergic airway disease
    Christian Taube
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 169:6482-9. 2002
    ....
  26. ncbi IL-13 is necessary, not simply sufficient, for epicutaneously induced Th2 responses to soluble protein antigen
    Christina A Herrick
    Department of Dermatology and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 170:2488-95. 2003
    ....
  27. pmc Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor alpha 2
    Nancy Wood
    Department of Respiratory Disease, Wyeth Research, Cambridge, MA 02140, USA
    J Exp Med 197:703-9. 2003
    ..These results are consistent with a phenotype of enhanced IL-13 responsiveness and demonstrate a role for endogenous IL-13 and IL-13Ralpha2 in regulating immune responses in wild-type mice...
  28. ncbi Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity
    Omid Akbari
    Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, California, USA
    Nat Med 9:582-8. 2003
    ..Therapies that target V(alpha)14i NKT cells may be clinically effective in limiting the development of AHR and asthma...
  29. ncbi Dependence of IL-4, IL-13, and nematode-induced alterations in murine small intestinal smooth muscle contractility on Stat6 and enteric nerves
    Aiping Zhao
    Nutritional Requirements and Functions Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, U S Department of Agriculture, Beltsville, MD 20705, USA
    J Immunol 171:948-54. 2003
    ..Differences in these effects correlate with differences in the relative importance of these cytokines in the expulsion of enteric nematode parasites...
  30. pmc Both interleukin-4 (IL-4) and IL-4 receptor alpha signaling contribute to the development of hepatic granulomas with optimal antileishmanial activity
    Simona Stager
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Infect Immun 71:4804-7. 2003
    ..IL-4 and IL-13 appear to play little role in regulating collagen deposition in L. donovani-induced granulomas...
  31. ncbi Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation
    Zhou Zhu
    Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, Department of Internal Medicine, 300 Cedar Street, TAC S 441, New Haven, CT 06520 8057, USA
    Science 304:1678-82. 2004
    ..AMCase may thus be an important mediator of IL-13-induced responses in Th2-dominated disorders such as asthma...
  32. ncbi Mast cells, basophils, and eosinophils acquire constitutive IL-4 and IL-13 transcripts during lineage differentiation that are sufficient for rapid cytokine production
    Andre Gessner
    Institute of Clinical Microbiology, Immunology, and Hygiene University of Erlangen Nurnberg, Erlangen, Germany
    J Immunol 174:1063-72. 2005
    ..These novel findings have important implications for the prevention and therapeutic intervention of allergic and asthmatic diseases...
  33. ncbi The enhancement or prevention of airway hyperresponsiveness during reinfection with respiratory syncytial virus is critically dependent on the age at first infection and IL-13 production
    Azzeddine Dakhama
    Department of Pediatrics, Division of Cell Biology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 175:1876-83. 2005
    ....
  34. ncbi Intraepithelial NK cell-derived IL-13 induces intestinal pathology associated with nematode infection
    Jacqueline R McDermott
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    J Immunol 175:3207-13. 2005
    ..These data provide the first evidence that intestinal tissue restructuring during helminth infection is an innate event dependent on IL-13 production by NK cells resident in the epithelium of the intestine...
  35. ncbi IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis
    Stefan Fichtner-Feigl
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10 CRC 5W3864, 10 Center Drive, Bethesda, Maryland 20892, USA
    Nat Med 12:99-106. 2006
    ..These data suggest that IL-13Ralpha(2) signaling during prolonged inflammation is an important therapeutic target for the prevention of TGF-beta(1)-mediated fibrosis...
  36. pmc Functional importance of regional differences in localized gene expression of receptors for IL-13 in murine gut
    Motoko Morimoto
    Department of Medicine and Mucosal Biology Research Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 176:491-5. 2006
    ..The pronounced differences in the expression of IL-13Ralpha2 suggest that the gut has developed sophisticated mechanisms for controlling the physiological and pathophysiological activities of IL-13...
  37. pmc Visceral Leishmania donovani infection in interleukin-13-/- mice
    Henry W Murray
    Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Infect Immun 74:2487-90. 2006
    ..By itself, interleukin-13 does not appear to materially influence acquired resistance in this intracellular infection...
  38. pmc Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion
    Padraic G Fallon
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Exp Med 203:1105-16. 2006
    ..We demonstrate that these IL-25-regulated cells appear rapidly in the draining lymph nodes, implicating them as a source of type 2 cytokines during initiation of worm expulsion...
  39. pmc Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system
    David Voehringer
    Howard Hughes Medical Institute, Departments of Medicine and Microbiology Immunology, University of California San Francisco, San Francisco, CA 94143, USA
    J Exp Med 203:1435-46. 2006
    ..Thus, components of type 2 immunity mediated by IL-4/IL-13 are partitioned between T cell-dependent IgE and an innate non-eosinophil tissue component, suggesting new strategies for interventions in allergic immunity...
  40. ncbi Pulmonary inflammation and emphysema: role of the cytokines IL-18 and IL-13
    Tomoaki Hoshino
    Department of Internal Medicine 1, Kurume University School of Medicine, Kurume, Japan
    Am J Respir Crit Care Med 176:49-62. 2007
    ..Our results demonstrate that IL-18 overproduction in the lungs can induce lung diseases, such as pulmonary inflammation, lung fibrosis, and COPD...
  41. ncbi T helper 2 cytokines inhibit autophagic control of intracellular Mycobacterium tuberculosis
    James Harris
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, University of New Mexico School of Medicine, 915 Camino de Salud NE, Albuquerque, NM 87131, USA
    Immunity 27:505-17. 2007
    ..These findings establish a mechanism through which Th1-Th2 polarization differentially affects the immune control of intracellular pathogens...
  42. ncbi IL-13 induces disease-promoting type 2 cytokines, alternatively activated macrophages and allergic inflammation during pulmonary infection of mice with Cryptococcus neoformans
    Uwe Muller
    Institute of Immunology, College of Veterinary Medicine, University of Leipzig, Leipzig, Germany
    J Immunol 179:5367-77. 2007
    ..This indicates that IL-13 contributes to fatal allergic inflammation during C. neoformans infection...
  43. ncbi Differences in expression, affinity, and function of soluble (s)IL-4Ralpha and sIL-13Ralpha2 suggest opposite effects on allergic responses
    Marat Khodoun
    Cincinnati Veterans Affairs Medical Center, Cincinnati, OH 45220, USA
    J Immunol 179:6429-38. 2007
    ....
  44. pmc Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis
    A Munitz
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 105:7240-5. 2008
    ..Taken together, our data provide a comprehensive mechanistic analysis of the critical role by which IL-13Ralpha1 mediates allergic lung pathology and highlight unforeseen roles for the type II IL-4R...
  45. pmc Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease
    Edy Y Kim
    Department of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Med 14:633-40. 2008
    ....
  46. doi Basophil effector function and homeostasis during helminth infection
    Caspar Ohnmacht
    Institute for Immunology, University of Munich, Munich, Germany
    Blood 113:2816-25. 2009
    ....
  47. pmc Cytokine-secreting follicular T cells shape the antibody repertoire
    R Lee Reinhardt
    Howard Hughes Medical Institute and Departments of Medicine and Microbiology and Immunology, University of California San Francisco, USA
    Nat Immunol 10:385-93. 2009
    ..Our findings support a model in which B cells compete for cytokines produced by follicular helper T cells that shape the affinity and isotype of the antibody response...
  48. pmc Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
    Daniel R Neill
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nature 464:1367-70. 2010
    ..of allergic asthma-consists of responses dominated by the cardinal type-2 cytokines interleukin (IL)4, IL5 and IL13 (ref. 5)...
  49. pmc Systemically dispersed innate IL-13-expressing cells in type 2 immunity
    April E Price
    Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco, CA 94143 0795, USA
    Proc Natl Acad Sci U S A 107:11489-94. 2010
    ..Widely dispersed innate type 2 helper cells, which we designate Ih2 cells, play an integral role in type 2 immune responses...
  50. pmc Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis
    DAVINA WU
    Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94143 0795, USA
    Science 332:243-7. 2011
    ..Our results suggest that eosinophils play an unexpected role in metabolic homeostasis through maintenance of adipose AAMs...
  51. pmc Genetic analysis of basophil function in vivo
    Brandon M Sullivan
    Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California, USA
    Nat Immunol 12:527-35. 2011
    ..Although targeted deletion of IL-4 and IL-13 in either CD4(+) T cells or basophils had a minimal effect on worm clearance, deletion from both lineages demonstrated a nonredundant role for basophil cytokines in primary helminth immunity...
  52. pmc Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis
    Khoa D Nguyen
    Immunology Program, Stanford University, Palo Alto, California 94305, USA
    Nature 480:104-8. 2011
    ..Thus, we have discovered a role for alternatively activated macrophages in the orchestration of an important mammalian stress response, the response to cold...
  53. pmc Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity
    Hong Erh Liang
    Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California, USA
    Nat Immunol 13:58-66. 2011
    ..The distinct localization and cellular expression of IL-4 and IL-13 explains their unique roles during allergic immunity...
  54. doi Pulmonary innate lymphoid cells are major producers of IL-5 and IL-13 in murine models of allergic asthma
    Roel G J Klein Wolterink
    Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands
    Eur J Immunol 42:1106-16. 2012
    ..We conclude that both ILC2s and Th2 cells produce large amounts of IL-5 and IL-13 that contribute to allergic airway inflammation...
  55. doi IL-13-mediated immunological control of enterochromaffin cell hyperplasia and serotonin production in the gut
    M Manocha
    Farncombe Family Digestive Health Research Institute, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Mucosal Immunol 6:146-55. 2013
    ..Herein we studied the role of interleukin 13 (IL-13) in EC cell biology by utilizing IL-13-deficient (IL-13-/-) mice and BON cells (a model for human EC ..
  56. pmc IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes/macrophages
    Ashish Bhattacharjee
    Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Free Radic Biol Med 54:1-16. 2013
    ....
  57. pmc Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages
    Ari B Molofsky
    Howard Hughes Medical Institute, University of California, San Francisco, San Francisco 94143, USA
    J Exp Med 210:535-49. 2013
    ..Thus, ILC2s are resident in VAT and promote eosinophils and AAM implicated in metabolic homeostasis, and this axis is enhanced during Th2-associated immune stimulation...
  58. pmc Simultaneous disruption of interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responses
    G J McKenzie
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    J Exp Med 189:1565-72. 1999
    ..We conclude that IL-4 and IL-13 cooperate to initiate rapid Th2 cell-driven responses, and that although their functions overlap, they perform additive roles...
  59. ncbi Studies of murine schistosomiasis reveal interleukin-13 blockade as a treatment for established and progressive liver fibrosis
    M G Chiaramonte
    Schistosomiasis Immunology and Pathology Unit, Immunobiology Section, Laboratory of Parasitic Diseases and the Center for Information Technology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Hepatology 34:273-82. 2001
    ....
  60. pmc Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response
    Monica G Chiaramonte
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 197:687-701. 2003
    ..Together, these studies illustrate the central role played by the IL-13Ralpha2 in the down-regulation of a chronic and pathogenic Th2-mediated immune response...
  61. ncbi A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes
    K D Brown
    Department of Molecular Biology, DNAX Research Institute, Palo Alto, CA 94304
    J Immunol 142:679-87. 1989
    ..One of the small, inducible, secreted proteins has a predicted mature N terminus identical to that of the previously described macrophage inflammatory protein...
  62. ncbi A distinct role for interleukin-13 in Th2-cell-mediated immune responses
    G J McKenzie
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Curr Biol 8:339-42. 1998
    ..These data support a unique role for IL-13 in Th2-cell-mediated immune responses and demonstrate that IL-13 and IL-4 are not redundant...
  63. ncbi Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
    Douglas A Kuperman
    Lung Biology Center, Department of Medicine and Cardiovascular Research Institute, University of California San Francisco School of Medicine, San Francisco, California, USA
    Nat Med 8:885-9. 2002
    ..These results demonstrate the importance of direct effects of IL-13 on epithelial cells in causing two central features of asthma...
  64. pmc IL-4 engagement of the type I IL-4 receptor complex enhances mouse eosinophil migration to eotaxin-1 in vitro
    Nicola M Heller
    Department of Microbiology and Immunology and the Center for Vascular and Inflammatory Diseases, The University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 7:e39673. 2012
    ..The direct effect(s) of IL-4 and IL-13 on mouse eosinophils are not clear. The goal of this study was determine the effect of IL-4 and IL-13 on mouse eosinophil function...
  65. pmc An altered immune response, but not individual cationic antimicrobial peptides, is associated with the oral attenuation of Ara4N-deficient Salmonella enterica serovar Typhimurium in mice
    Kristi L Strandberg
    Center for Microbial Interface Biology, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 7:e49588. 2012
    ....
  66. ncbi Canine interleukin-13: molecular cloning of full-length cDNA and expression of biologically active recombinant protein
    S Yang
    Heska Corporation, Fort Collins, CO 80525, USA
    J Interferon Cytokine Res 20:779-85. 2000
    ..The gene sequence and biologically active recombinant protein for CaIL-13 will be useful reagents to determine the role of IL-13 in the regulation of canine immune responses...
  67. ncbi An essential role for IL-13 in maintaining a non-healing response following Leishmania mexicana infection
    James Alexander
    Department of Immunology, University of Strathclyde, Strathclyde Institute for Biomedical Sciences, 27 Taylor Street, Glasgow G4 0NR, Scotland, GB, UK
    Eur J Immunol 32:2923-33. 2002
    ..Collectively our results suggest that IL-4 plays a critical role in early lesion development, and that IL-13 plays a crucial part in maintaining a chronic non-healing infection...
  68. ncbi The Th2 cell cytokines IL-4 and IL-13 regulate found in inflammatory zone 1/resistin-like molecule alpha gene expression by a STAT6 and CCAAT/enhancer-binding protein-dependent mechanism
    Adrian M Stütz
    Department of Allergic Diseases, Novartis Research Institute, Brunnerstrasse 59, A 1630 Vienna, Austria
    J Immunol 170:1789-96. 2003
    ..Induction of FIZZ2 gene expression most likely occurs independent of a direct effect by these cytokines and may be due to indirect STAT6-driven mechanisms...
  69. ncbi Glatiramer acetate (Copaxone) regulates nitric oxide and related cytokine secretion in experimental autoimmune encephalomyelitis
    Basak Kayhan
    Department of Immunology, The Weizmann Institute of Science, PO Box 26, Rehovot 76100, Israel
    Immunol Lett 88:185-92. 2003
    ..On the other hand, the secretion level of NO modulating cytokines IL-10 and IL-13 was significantly augmented. The correlation between these findings and the therapeutic effect of GA is discussed...
  70. ncbi Translational control of inducible nitric oxide synthase by IL-13 and arginine availability in inflammatory macrophages
    Stefan El-Gayar
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen Nuremberg, Erlangen, Germany
    J Immunol 171:4561-8. 2003
    ..From these results, we conclude that arginine not only functions as a substrate for iNOS, but is also critical for maintaining normal levels of iNOS protein in cytokine-stimulated macrophages...
  71. ncbi Mast cells, Fc epsilon RI, and IL-13 are required for development of airway hyperresponsiveness after aerosolized allergen exposure in the absence of adjuvant
    Christian Taube
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 172:6398-406. 2004
    ..These results show that FcepsilonRI is important for the development of AHR after an aerosolized allergen sensitization protocol and that this effect is mediated through FcepsilonRI on mast cells and production of IL-13 in the lung...
  72. ncbi Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation
    Samuel M Pope
    Division of Allergy and Immunology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Biol Chem 280:13952-61. 2005
    ..Mechanistic analysis identified IL13-induced eotaxin-2 expression by macrophages in a distinct lung compartment (luminal inflammatory cells) compared ..
  73. ncbi IL-13 regulates the immune response to inhaled antigens
    Jocelyn Padilla
    James P Mara Center for Lung Diseases, St Luke s Roosevelt Hospital and Department of Pathology, Columbia University, New York, NY 10019, USA
    J Immunol 174:8097-105. 2005
    ..These data indicate that blockade of IL-13 may have therapeutic potential for controlling the immune response to inhaled Ags...
  74. ncbi Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice
    Wen Lin
    Division of Immunology, Allergy and Rheumatology, Department of Pediatrics, The David Geffen School of Medicine at the University of California at Los Angeles, MDCC 12 430, 10833 Le Conte Ave, Los Angeles, CA 90095 1752, USA
    J Allergy Clin Immunol 116:1106-15. 2005
    ..In human subjects loss-of-function Foxp3 mutations trigger lymphoproliferation, autoimmunity, and intense allergic inflammation in a disease termed immune dysregulation polyendocrinopathy enteropathy-X-linked syndrome...
  75. ncbi Production of IL-13 in spleen cells by IL-18 and IL-12 through generation of NK-like cells
    Haruyasu Ueda
    Laboratory of Host Defenses, Institute for Advanced Medical Sciences, Hyogo College of Medicine, 1 1, Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Cytokine 33:179-87. 2006
    ..These results show that IL-18 and IL-12 generates the NK-like cells in NWC by a process mediated by GM-CSF that are ready for producing IL-13...
  76. pmc Infection with Syphacia obvelata (pinworm) induces protective Th2 immune responses and influences ovalbumin-induced allergic reactions
    Chesney Michels
    Health Science Faculty, Institute of Infectious Disease and Molecular Medicine IIDMM, University of Cape Town, Cape Town, South Africa
    Infect Immun 74:5926-32. 2006
    ..obvelata infection is able to influence nonrelated laboratory experiments. The latter outcome highlights the importance of maintaining mice for use as experimental models under pinworm-free conditions...
  77. ncbi Comparative roles of IL-4, IL-13, and IL-4Ralpha in dendritic cell maturation and CD4+ Th2 cell function
    Dianne C Webb
    Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia
    J Immunol 178:219-27. 2007
    ..The affinity of IL-4Ralpha also appears to be a determinant in the balance between Th2 and IFN-gamma responses and thus the severity of allergic disease...
  78. ncbi Inhibition of NF-kappaB activation reduces the tissue effects of transgenic IL-13
    Svetlana P Chapoval
    Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 179:7030-41. 2007
    ..PS1145 inhibits caspase activation and up-regulates inhibitor of apoptosis protein cellular-inhibitor of apoptosis protein 1 (c-IAP-1). Therefore, NF-kappaB is an attractive target for immunotherapy of IL-13-mediated diseases...
  79. pmc The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitis
    Benno Weigmann
    Institute of Molecular Medicine, Johanes Gutenberg Univeristy, 55131 Mainz, Germany
    J Exp Med 205:2099-110. 2008
    ..NFATc2 in T cells thus emerges as a potentially new therapeutic target for inflammatory bowel diseases...
  80. ncbi Intradermal administration of thymic stromal lymphopoietin induces a T cell- and eosinophil-dependent systemic Th2 inflammatory response
    Heidi K Jessup
    Inflammation Research, Amgen, Seattle, WA 98119, USA
    J Immunol 181:4311-9. 2008
    ..TSLP-induced responses were significantly, but not completely reduced in IL-4- and IL-13-deficient mice. These results shed light on the pathways and cell types involved in TSLP-induced inflammation...
  81. pmc Cytokine signaling regulates the outcome of intracellular macrophage parasitism by Cryptococcus neoformans
    Kerstin Voelz
    University of Birmingham, Edgbaston, United Kingdom
    Infect Immun 77:3450-7. 2009
    ..These results help explain the observed poor prognosis associated with the Th2 cytokine profile (e.g., in human immunodeficiency virus-infected patients)...
  82. doi IL-13 from Th2-type cells suppresses induction of antigen-specific Th1 immunity in a T-cell lymphoma
    Praveen Deepak
    Centre of Advanced Study in Zoology, Department of Zoology, Faculty of Science, Banaras Hindu University, Varanasi 221 005, Uttar Pradesh, India
    Int Immunol 22:53-63. 2010
    ....
  83. pmc The phenotype of murine wound macrophages
    Jean M Daley
    Division of Surgical Research, Rhode Island Hospital, Providence, RI 02903, USA
    J Leukoc Biol 87:59-67. 2010
    ..Wound macrophages exhibit a complex phenotype,which includes traits associated with alternative and classical activation and changes as the wound matures.The wound macrophage phenotype does not require IL-4 or IL-13...
  84. pmc Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity
    Christopher R Weber
    Department of Pathology, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 285:12037-46. 2010
    ..Interactions between these otherwise distinct tight junction regulatory pathways may contribute to IBD pathogenesis...
  85. pmc Apoptotic cells activate NKT cells through T cell Ig-like mucin-like-1 resulting in airway hyperreactivity
    Hyun Hee Lee
    Division of Immunology and Allergy, Department of Pediatrics, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 185:5225-35. 2010
    ..Furthermore, these results provide evidence for a novel innate pathway that results in airway hyperreactivity and may help to explain how TIM-1 and NKT cells regulate asthma...
  86. ncbi Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells
    G Zurawski
    Dept of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304 1104
    Immunol Today 15:19-26. 1994
    b>Interleukin 13 (IL-13) is a recently described protein secreted by activated T cells which is a potent in vitro modulator of human monocyte and B-cell functions...
  87. ncbi Interleukin-13 (IL-13) induces IL-1 receptor antagonist gene expression and protein synthesis in peripheral blood mononuclear cells: inhibition by an IL-4 mutant protein
    E Vannier
    Department of Medicine, Tufts University of Medicine, Boston, Masachusetts USA
    Blood 87:3307-15. 1996
    ..Our results suggest that the commonality between IL-13 and IL-4 in inducing IL-1Ra synthesis results from the engagement of a subunit common to both receptors...
  88. ncbi Interleukin-4 and -13 inhibit tumor necrosis factor-alpha mRNA translational activation in lipopolysaccharide-induced mouse macrophages
    T Mijatovic
    Laboratoire de Chimie Biologique, Departement de Biologie Moleculaire, Universite Libre de Bruxelles, 1640 Rhode Saint Genèse, Brussels, Belgium
    J Biol Chem 272:14394-8. 1997
    ..Transfection of reporter gene constructs containing different regions of the TNF-alpha gene revealed that the inhibitory action of IL-4 and IL-13 is mediated by the UA-rich sequence present in the TNF-alpha mRNA 3'-untranslated region...
  89. ncbi Tpm1, a locus controlling IL-12 responsiveness, acts by a cell-autonomous mechanism
    M L Guler
    Department of Pathology and Center for Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 162:1339-47. 1999
    ..This result strongly implies that despite the proximity of our locus to the IL-13/IL-4 gene cluster, these cytokines are not candidates for Tpm1...
  90. pmc Genomic interval engineering of mice identifies a novel modulator of triglyceride production
    Y Zhu
    Genome Sciences Department, Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 97:1137-42. 2000
    ....
  91. ncbi Identification of 40 genes on a 1-Mb contig around the IL-4 cytokine family gene cluster on mouse chromosome 11
    S E Wenderfer
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, Cincinnati, Ohio 45267 0524, USA
    Genomics 63:354-73. 2000
    Five related cytokine genes, interleukin 3 (Il3), interleukin 4 (Il4), interleukin 5 (Il5), interleukin 13 (Il13), and granulocyte-macrophage colony-stimulating factor (Csfgm or Csf2), are tightly linked on mouse chromosome 11...
  92. ncbi Interleukin-13 gene expression is regulated by GATA-3 in T cells: role of a critical association of a GATA and two GATG motifs
    Cecile Lavenu-Bombled
    Institut Cochen INSERM, CNRS, Universite Paris V, Departement d Hematologie, Maternite Port Royal, 123 Bd de Port Royal, 75014 Paris, France
    J Biol Chem 277:18313-21. 2002
    ..Altogether, these results indicate an important role of GATA-3 in CD8 cytokine gene expression and demonstrate that a critical network of GATA binding sites highly modulates GATA-3 activity...
  93. ncbi Eotaxin expression by epithelial cells and plasma cells in chronic asthma
    Rakesh K Kumar
    Inflammation Research Unit, Department of Pathology, University of New South Wales, Sydney, Australia
    Lab Invest 82:495-504. 2002
    ..Although high eotaxin levels alone are not sufficient to cause recruitment of eosinophils into the airways, recurrent exposure may generate or up-regulate additional signals required for eosinophil chemotaxis...
  94. ncbi Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and -independent pathways
    Chun Geun Lee
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8057, USA
    J Biol Chem 277:35466-74. 2002
    ..These responses are mediated by multiple mechanisms with mucus metaplasia being dependent on and the inflammation and fibrosis being independent of an IL-13/IL-4R(alpha)/STAT-6 activation pathway...
  95. ncbi Role of STAT6 and mast cells in IL-4- and IL-13-induced alterations in murine intestinal epithelial cell function
    Kathleen B Madden
    Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 169:4417-22. 2002
    ..The effects of IL-4 and IL-13 on intestinal epithelial cell function may play a critical role in host protection against gastrointestinal nematodes...
  96. ncbi Contribution of antigen-primed CD8+ T cells to the development of airway hyperresponsiveness and inflammation is associated with IL-13
    Nobuaki Miyahara
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 172:2549-58. 2004
    ..These data suggest that Ag-primed CD8(+) T cells are required for the full development of AHR and airway inflammation, which appears to be associated with IL-13 production from these primed T cells...
  97. ncbi Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region
    Patrick E Fields
    Section of Immunobiology and Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 21:865-76. 2004
    ..We postulate that these sites function alone or in combination with other regulatory elements to coordinate gene expression in the Th2 cytokine locus...
  98. ncbi IgE generation and mast cell effector function in mice deficient in IL-4 and IL-13
    Susan C Fish
    Wyeth Research, Cambridge, MA 02140, USA
    J Immunol 174:7716-24. 2005
    ..These findings suggest that a mechanism for IgE production exists in vivo that is independent of IL-4 or IL-13...
  99. ncbi Probabilistic regulation in TH2 cells accounts for monoallelic expression of IL-4 and IL-13
    Liying Guo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Immunity 23:89-99. 2005
    Il4 and Il13, closely linked genes, are expressed monoallelically in TH2 cells...
  100. ncbi Mechanisms of peripheral tolerance following intracameral inoculation are independent of IL-13 or STAT6
    Takahiko Nakamura
    Ocular Immunology Group, Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 175:2643-6. 2005
    ....
  101. ncbi Inhibition of hormone and cytokine-stimulated osteoclastogenesis and bone resorption by interleukin-4 and interleukin-13 is associated with increased osteoprotegerin and decreased RANKL and RANK in a STAT6-dependent pathway
    Py Palmqvist
    Departments of Oral Cell Biology and Periodontics, Umea University, Umeå S 901 87, Sweden
    J Biol Chem 281:2414-29. 2006
    ..The data indicate that IL-4 and IL-13, via a STAT6-dependent pathway, inhibit osteoclast differentiation and bone resorption by activating receptors on osteoblasts and osteoclasts that affect the RANKL/RANK/OPG system...

Research Grants24

  1. Transgenic Cytokines in COPD
    Tao Zheng; Fiscal Year: 2007
    ..3) Characterize the expression and roles of IL-13 and/or IFN-gamma in murine CS-induced emphysema. ..
  2. Genetic Factors Controlling Effector Function of TGF-beta in COPD and Fibrosis
    Chun Geun Lee; Fiscal Year: 2011
    ..AIM #4. Define the genes that determine whether TGF-b1 induceds a predominantly fibrotic versus emphysematous response in C57BL/6 and Balb/c mice. ..
  3. CAPACITATIVE CALCIUM ENTRY DEFECT IN IMMUNE DEFICIENCY
    Anjana Rao; Fiscal Year: 2002
    ..Deletion mapping using spectral karyotyping and microsatellite markers will be used to further narrow down the chromosomal region involved in the defect and candidate genes in this region will be evaluated. ..
  4. Direct IL-4 and IL-13 effects on pulmonary smooth muscle in allergic airway disea
    FRED DOUGLASS FINKELMAN; Fiscal Year: 2010
    ..Proposed studies with a mouse model in which airway hyperresponsiveness is induced solely by direct IL-4 and IL-13 effects on smooth muscle should help to elucidate these mechanisms and may reveal new approaches for asthma therapy. ..
  5. Fibroproliferation in Bronchiolitis Obliterans Syndrome
    Vibha Lama; Fiscal Year: 2008
    ..Martinez MD, MS and Marc Peters-Golden MD, both of whom are well-funded researchers with a long track record of mentoring. ..
  6. Akt activation sustains silica induced inflammation
    CELINE BEAMER; Fiscal Year: 2006
    ..abstract_text> ..
  7. Manipulation of T cell tolerance with small organic mol*
    Anjana Rao; Fiscal Year: 2005
    ..The hope is that the 'information obtained from this pilot R21 proposal will eventually be extended to whole animal models of transplant and tumour rejection, allergy and autoimmune disease. ..
  8. Aquaporin 5 (AQP5) in Lung Fluid Homeostasis
    CARISSA KRANE; Fiscal Year: 2004
    ..This combinatorial approach will provide valuable information for the identification of new mechanistic pathways critical for the development of novel drug targets for the treatment of asthma. ..
  9. HOST IMMUNOREGULATION OF ANTILEISHMANIAL CHEMOTHERAPY
    Henry Murray; Fiscal Year: 2005
    ..And Aim 3: Characterize immunostimulation in AmB's efficacy, and in recrudescent infection following AmB therapy, pinpoint the likely cytokine-driven T cell mechanism which prevents post-treatment relapse. ..
  10. CYTOKINE REGULATION OF A MOUSE MODEL OF ASTHMA
    Fred Finkelman; Fiscal Year: 2003
    ..By clarifying the mechanisms by which cytokines induce pulmonary inflammation and airway responsiveness, the proposed studies will provide information important for rational therapy for asthma. ..
  11. RESPIRATORY SYNCYTIAL VIRUS ON ALLERGIC AIRWAY DISEASE
    R Peebles; Fiscal Year: 2003
    ....
  12. IL4R AND IMMUNITY TO GI NEMATODE PARASITES
    Fred Finkelman; Fiscal Year: 2003
    ....
  13. REGULATION OF IL4 PRODUCTION IN VIVO
    Fred Finkelman; Fiscal Year: 2002
    ..The results of these experiments will provide a better understanding of how IL-4 responses are regulated in vivo; this understanding will enhance the ability to control disorders that are regulated by IL-4. ..
  14. TH2-MEDIATED INFLAMMATORY RESPONSES IN THE SKIN AND LUNG
    CHRISTINA HERRICK; Fiscal Year: 2002
    ..My goal is to continue basic science investigation of atopic skin disease as a junior faculty member in the Department of Dermatology at Yale School of Medicine. ..
  15. Th2 responses in the cutaneous environment
    Christina A Herrick; Fiscal Year: 2010
    ..abstract_text> ..
  16. Regulation of Inflammation in Asthma by Fas Ligand
    Angela Haczku; Fiscal Year: 2009
    ..Finally, in order to help support the hypothesis that pro-apoptotic FasL activity characterized in human airway cells is truly physiologic, we will perform challenge studies in mice under FasL neutralizing conditions. ..
  17. Surfactant-Protein Innate Immunity in an Asthma Model
    Angela Haczku; Fiscal Year: 2008
    ..The potential opportunity to interfere with allergic sensitization by SP-D treatment bears high clinical significance. [unreadable] [unreadable]..
  18. Host Immunoregulation of Response to Antileishmanial Chemotherapy
    Henry Murray; Fiscal Year: 2007
    ..abstract_text> ..
  19. Cellular targets of IL-4 and IL-13 in worm expulsion
    Fred Finkelman; Fiscal Year: 2007
    ..It should also be useful for the intelligent prediction of risks associated with agents that inhibit allergic inflammation. ..
  20. Prostacyclin (PG12) Regulation of Respiratory Syncytial Virus (RS)induced Illness
    RAY PEEBLES; Fiscal Year: 2007
    ..The proposed studies will define the mechanism by which PGI 2 modulates the immune response to RSV infection and protects against RSV-induced disease. ..
  21. PGE2 Regulation of Allergic Inflammation in the Lung
    RAY PEEBLES; Fiscal Year: 2007
    ..Defining the role of PGE2 and the cellular receptors for PGE2 in the immunobiology of allergic inflammation in the lung may result in novel targets for drug development. [unreadable] [unreadable]..
  22. Role of Inflammatory Cytokines in the Allergic Response
    Fred Finkelman; Fiscal Year: 2007
    ..abstract_text> ..
  23. The stress of dry eye on corneal barrier function
    CINTIA DE PAIVA; Fiscal Year: 2006
    ..TJ and LEP expression will be evaluated by laser scanning confocal microscopy and immunostaining. Pro inflammatory mediator expression will be evaluated by Western Blot, ELISA and the Luminex Multiplex Assay. [unreadable] [unreadable]..