Genomes and Genes
Gene Symbol: Il10
Description: interleukin 10
Alias: CSIF, Il-10, interleukin-10, cytokine synthesis inhibitory factor
Publications202 found, 100 shown here
- IL-10 mediates susceptibility to Leishmania donovani infectionM L Murphy
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
Eur J Immunol 31:2848-56. 2001..Together these studies demonstrate for the first time that IL-10 is a critical component of the immune response that inhibits resistance to L. donovani...
- CCR8 is expressed by antigen-elicited, IL-10-producing CD4+CD25+ T cells, which regulate Th2-mediated granuloma formation in miceChristine M Freeman
Department of Pathology, University of Michigan Medical School, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI 48105, USA
J Immunol 174:1962-70. 2005..Thus, IL-10-producing, CCR8+CD4+CD25+CD44+ T cells are generated during SEA challenge, which augment the Th2-mediated eosinophil-rich response to the parasite Ags...
- Helminth infection can reduce insulitis and type 1 diabetes through CD25- and IL-10-independent mechanismsQian Liu
Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 S Orange Avenue, Newark, New Jersey 07103, USA
Infect Immun 77:5347-58. 2009..These findings suggest that infection with H. polygyrus significantly inhibits T1D in NOD mice through CD25- and IL-10-independent mechanisms and also reduces the severity of T1D when administered late after the onset of insulitis...
- Endothelial cells augment the suppressive function of CD4+ CD25+ Foxp3+ regulatory T cells: involvement of programmed death-1 and IL-10Tanja Bedke
Department of Dermatology, University Hospital Heidelberg, Heidelberg, Germany
J Immunol 184:5562-70. 2010..Therefore, one can speculate that T(reg) during transendothelial transmigration become "armed" for their suppressive function(s) to be carried out in peripheral tissues sites...
- IL-10 production differentially influences the magnitude, quality, and protective capacity of Th1 responses depending on the vaccine platformPatricia A Darrah
Cellular Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 207:1421-33. 2010..Overall, we delineate distinct mechanisms by which vaccines elicit protective Th1 responses and underscore the importance of multifunctional CD4(+) T cells...
- Interleukin-10-deficient mice develop chronic enterocolitisR Kuhn
Institute for Genetics, University of Cologne, Federal Republic of Germany
Cell 75:263-74. 1993..These results indicate that the bowel inflammation in the mutants originates from uncontrolled immune responses stimulated by enteric antigens and that IL-10 is an essential immunoregulator in the intestinal tract...
- B cells regulate autoimmunity by provision of IL-10Simon Fillatreau
University of Edinburgh, Institute of Cell, Animal and Population Biology, King s Buildings West Mains Road, Edinburgh EH9 3JT, UK
Nat Immunol 3:944-50. 2002..B cells from recovered mice produced interleukin 10 (IL-10) in response to autoantigen...
- Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1Olaf Gross
Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
Immunity 36:388-400. 2012..Because inflammasomes contribute to the pathology of numerous chronic inflammatory diseases such as gout and diabetes, IL-1α antagonists may be beneficial in the treatment of these disorders...
- Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clonesD F Fiorentino
Department of Immunology, DNAX Research Institute, Palo Alto, California 94304
J Exp Med 170:2081-95. 1989A cytokine synthesis inhibitory factor (CSIF) is secreted by Th2 clones in response to Con A or antigen stimulation, but is absent in supernatants from Con A-induced Th1 clones...
- The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cureY Belkaid
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 4 Rm 126, Center Dr MSC 0425, Bethesda, MD 20892, USA
J Exp Med 194:1497-506. 2001....
- The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27Lionel Apetoh
Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Nat Immunol 11:854-61. 2010Type 1 regulatory T cells (Tr1 cells ) that produce interleukin 10 (IL-10) are instrumental in the prevention of tissue inflammation, autoimmunity and graft-versus-host disease...
- Type I interferon inhibits interleukin-1 production and inflammasome activationGreta Guarda
Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
Immunity 34:213-23. 2011..Our findings may thus explain the effectiveness of type I IFN in the treatment of inflammatory diseases but also the observed "weakening" of the immune system after viral infection...
- Posttranscriptional regulation of II10 gene expression allows natural killer cells to express immunoregulatory functionAsher Maroof
Immunology and Infection Unit, Hull York Medical School and Department of Biology, University of York, Wentworth Way, York YO10 5YW, UK
Immunity 29:295-305. 2008....
- Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen doseMargarida Saraiva
Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
Immunity 31:209-19. 2009..IL-10 expression also correlated with c-maf expression. Despite having distinct functions in protection against pathogens, all Th cells share the important task of controlling overexuberant immune responses by means of IL-10 production...
- Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10Juan M Ilarregui
Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
Nat Immunol 10:981-91. 2009..Our findings identify a tolerogenic circuit linking galectin-1 signaling, IL-27-producing DCs and IL-10-secreting T cells, which has broad therapeutic implications in immunopathology...
- Autocrine regulation of pulmonary inflammation by effector T-cell derived IL-10 during infection with respiratory syncytial virusJie Sun
The Beirne B Carter Center for Immunology Research, The University of Virginia, Charlottesville, Virginia, United States of America
PLoS Pathog 7:e1002173. 2011..Our findings suggest a potentially critical role of effector T cell-derived IL-10 in controlling disease severity in clinical RSV infection...
- In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alphaR T Gazzinelli
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
J Immunol 157:798-805. 1996..Together the data suggest that endogenous IL-10 synthesis plays an important role in vivo in down-regulating monokine and IFN-gamma responses to acute intracellular infection, thereby preventing host immunopathology...
- Activating receptors promote NK cell expansion for maintenance, IL-10 production, and CD8 T cell regulation during viral infectionSeung Hwan Lee
Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
J Exp Med 206:2235-51. 2009..The Ly49H-dependent protection mechanism delivered in the absence of Prf1 was a result of interleukin 10 production, by the sustained NK cells, to regulate the magnitude of CD8 T cell responses...
- A critical role for IL-10 in limiting inflammation during toxoplasmic encephalitisEmma H Wilson
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6008, USA
J Neuroimmunol 165:63-74. 2005..Together these results point to a vital role for IL-10 in the control of CD4(+) T cell mediated inflammation in the brain during TE...
- Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathwaysKatrin Kierdorf
Department of Neuropathology, University of Freiburg, Freiburg, Germany
Nat Neurosci 16:273-80. 2013..Our data provide cellular and molecular insights into the origin and development of microglia...
- Nonredundant roles for B cell-derived IL-10 in immune counter-regulationRajat Madan
Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
J Immunol 183:2312-20. 2009....
- TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cellsFrank Kaiser
Division of Immunoregulation, Medical Research Council National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
J Exp Med 206:1863-71. 2009....
- IL-10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral infectionDavid G Brooks
Department of Microbiology, Immunology and Molecular Genetics and the UCLA AIDS Institute, David Geffen School of Medicine, University of California Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 107:3018-23. 2010..On the other hand, lack of IL-10 signaling did not impact memory CD8 T cell development. We propose that blockade of IL-10 may be an effective adjuvant to specifically enhance CD4 T cell immunity and protection following vaccination...
- An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammationC Asseman
Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom
J Exp Med 190:995-1004. 1999..These findings provide the first clear evidence that IL-10 plays a nonredundant role in the functioning of regulatory T cells that control inflammatory responses towards intestinal antigens...
- CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasisAntonella Mencacci
Department of Experimental Medicine and Biochemical Science, University of Perugia, Perugia, Italy
J Immunol 169:3180-90. 2002..These data indicate that alternatively activated PMN expressing CD80 may adversely affect Th1-dependent resistance in fungal infections...
- Increased inflammation, impaired bacterial clearance, and metabolic disruption after gram-negative sepsis in Mkp-1-deficient miceW Joshua Frazier
Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, Columbus, OH 43205, USA
J Immunol 183:7411-9. 2009....
- IL-10 restricts activation-induced death of NK cells during acute murine cytomegalovirus infectionMaria A Stacey
Department of Infection, Immunity and Biochemistry, School of Medicine, Cardiff University, Cardiff, CF14 4XN, United Kingdom
J Immunol 187:2944-52. 2011..Therefore, we conclude that IL-10 contributes to antiviral innate immunity during acute infection by restricting activation-induced death in NK cells...
- Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitisBrian D Gulbransen
Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
Nat Med 18:600-4. 2012..Targeting Panx1 represents a new neuroprotective strategy to ameliorate the progression of IBD-associated dysmotility...
- Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitisMasako Murai
Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
Nat Immunol 10:1178-84. 2009..Here we show that interleukin 10 (IL-10) produced by CD11b(+) myeloid cells in recombination-activating gene 1-deficient (Rag1(-/-)) recipient ..
- Tumor-induced interleukin-10 inhibits type 1 immune responses directed at a tumor antigen as well as a non-tumor antigen present at the tumor siteB K Halak
Kimmel Cancer Center, Division of Medical Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Cancer Res 59:911-7. 1999..These studies demonstrate that tumor-induced IL-10 can block the generation of a tumor-specific type 1 immune response as well as subvert attempts to elicit a type 1 immune response to a non-tumor antigen at the tumor site...
- Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia modelMarina C Pils
Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
Eur J Immunol 40:443-8. 2010..In contrast, in an IL-10-regulated T-cell response to Trichuris muris infection, IL-10 acting on T cells or monocytes/macrophages/neutrophils is not critical for the control of the infection...
- Monocyte chemoattractant protein-1 contributes to gut homeostasis and intestinal inflammation by composition of IL-10-producing regulatory macrophage subsetYasuhiro Takada
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
J Immunol 184:2671-6. 2010..Moreover, MCP-1-dependent LPM2 subset may play an important role in maintenance of gut homeostasis in the steady state, and in the termination of excess inflammatory responses in the intestine, by producing IL-10...
- Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signalsAndre Boonstra
Division of Immunoregulation, National Institute for Medical Research, The Ridgeway, London NW7 1AA, United Kingdom
J Immunol 177:7551-8. 2006....
- Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouseMasahito Kamanaka
Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Immunity 25:941-52. 2006..These findings highlight the intestine as a unique site for induction of IL-10-producing T cells, which play a critical role in the regulation of inflammation in the gut...
- Interleukin-4 but not interleukin-10 protects against spontaneous and recurrent type 1 diabetes by activated CD1d-restricted invariant natural killer T-cellsQing Sheng Mi
Autoimmunity Diabetes Group, Robarts Research Institute, 1400 Western Road, London, Ontario N6G 2V4, Canada
Diabetes 53:1303-10. 2004..Our data identify an important role for IL-4 in the protection against type 1 diabetes by activated iNKT cells, and these findings have important implications for cytokine-based therapy of type 1 diabetes and islet transplantation...
- Mononuclear phagocyte-derived IL-10 suppresses the innate IL-12/IFN-gamma axis in lung-challenged aged miceBo Chin Chiu
Department of Cellular and Molecular Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
J Immunol 181:3156-66. 2008..Our data identify a novel mechanism of age-associated immune deficiency...
- Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine productionJose M Gonzalez-Navajas
Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
J Exp Med 207:2799-807. 2010..Our data identifies a new molecular pathway by which IL-1 signaling attenuates TLR9-mediated proinflammatory responses...
- CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLsJie Sun
The Beirne B Carter Center for Immunology Research, The University of Virginia, Charlottesville, Virginia, USA
Nat Immunol 12:327-34. 2011..These findings reveal a previously unrecognized pathway that coordinates signals derived from innate and helper T cells to control the production of a regulatory cytokine by CTLs during acute viral infection...
- Regulatory T cells inhibit acute IFN-γ synthesis without blocking T-helper cell type 1 (Th1) differentiation via a compartmentalized requirement for IL-10Dorothy K Sojka
The David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 108:18336-41. 2011..Interestingly, Tregs used different regulatory mechanisms to regulate IFN-γ (IL-10-dependent or -independent) subject to the target T-cell stage of activation and its tissue location...
- Interleukin-10 promotes Mycobacterium tuberculosis disease progression in CBA/J miceGillian L Beamer
Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA
J Immunol 181:5545-50. 2008..Our results indicate that IL-10 promotes TB disease progression. These findings have important diagnostic and/or therapeutic implications for the prevention of reactivation TB in humans...
- An anti-inflammatory role for carbon monoxide and heme oxygenase-1 in chronic Th2-mediated murine colitisShehzad Z Sheikh
Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
J Immunol 186:5506-13. 2011....
- Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammationFang Yan
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2576, USA
J Clin Invest 114:1272-80. 2004..These effects are reversed by WT, but not kinase-inactive, KSR1. We conclude that KSR1 has an essential protective role in the intestinal epithelial cell during inflammation through activation of cell survival pathways...
- TLR-2-activated B cells suppress Helicobacter-induced preneoplastic gastric immunopathology by inducing T regulatory-1 cellsAyca Sayi
Institute of Molecular Cancer Research, University of Zurich, Zurich 8057, Switzerland
J Immunol 186:878-90. 2011....
- Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritisT Kasama
Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA
J Clin Invest 95:2868-76. 1995..macrophage inflammatory protein 1 alpha (MIP-1 alpha) and macrophage inflammatory protein 2 (MIP-2), and interleukin 10 (IL-10) during the evolution of type II collagen-induced arthritis (CIA)...
- NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responsesTomohiro Watanabe
Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10 Room 11N238, 10 Center Drive, Bethesda, Maryland 20892, USA
Nat Immunol 5:800-8. 2004..Thus, CARD15 mutations may lead to disease by causing excessive T(H)1 responses...
- TLR-activated B cells suppress T cell-mediated autoimmunityVicky Lampropoulou
Deutsches Rheuma ForschungsZentrum, Berlin, Germany
J Immunol 180:4763-73. 2008..Altogether, our data indicate that B cells link recognition of microbial products via TLR to suppression of a T cell-mediated autoimmune disease...
- IL-21 mediates suppressive effects via its induction of IL-10Rosanne Spolski
Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 182:2859-67. 2009..Overall, our data indicate that IL-21 regulates immune responses at least in part by inducing IL-10 and reveal unanticipated immunosuppressive actions for this cytokine...
- 1,25-Dihydroxycholecalciferol prevents and ameliorates symptoms of experimental murine inflammatory bowel diseaseM T Cantorna
Department of Nutrition, College of Health and Human Development, The Pennsylvania State University, University Park, PA 16802, USA
J Nutr 130:2648-52. 2000..1, 25-Dihydroxycholecalciferol treatment (0.2 microgram/d) for as little as 2 wk blocked the progression and ameliorated (P < 0.05) symptoms in IL-10 KO mice with already established IBD...
- IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in miceMark S Wilson
Immunopathogenesis Section, Laboratory of Parasitic Diseases, and Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases NIAID, NIH, Bethesda, Maryland, USA
J Clin Invest 117:2941-51. 2007..Thus, IL-10 and IL-13Ralpha2 are both required to control chronic Th2-driven pathological responses...
- Chromatin-level regulation of the IL10 gene in T cellsSin Hyeog Im
Department of Life Science, Gwangju Institute of Science and Technology, 1 Oryong dong, Puk ku, Gwangju 500 712, Korea
J Biol Chem 279:46818-25. 2004The immunoregulatory cytokine interleukin 10 (IL-10) modulates the function of diverse immune and non-immune cells...
- Naturally occurring lung CD4(+)CD25(+) T cell regulation of airway allergic responses depends on IL-10 induction of TGF-betaAnthony Joetham
Department of Pediatrics, Division of Cell Biology, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Immunol 178:1433-42. 2007..By analogy, anti-TGF-beta treatment reduced regulatory T cell activity. These data identify naturally occurring lung CD4(+)CD25(+) T cells as capable of regulating lung allergic responses in an IL-10- and TGF-beta-dependent manner...
- IL-10 and natural regulatory T cells: two independent anti-inflammatory mechanisms in herpes simplex virus-induced ocular immunopathologyPranita P Sarangi
Comparative and Experimental Medicine Program, College of Veterinary Medicine, University of Tennessee, 1414 Cumberland Avenue, Knoxville, TN 37996, USA
J Immunol 180:6297-306. 2008..Our current investigations indicate that at least two independent anti-inflammatory mechanisms are involved in limiting the corneal lesions in SK, both of which may need to be modulated to control SK therapeutically...
- MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophagesJoanne Darragh
MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
Biochem J 425:595-602. 2010..MSKs therefore act as important negative regulators of inflammation following TLR activation...
- The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cellsMatthias Hesse
Laboratories of Parasitic Diseases and Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 172:3157-66. 2004..Thus, innate effectors and regulatory T cells producing IL-10 cooperate to reduce morbidity and prolong survival in schistosomiasis...
- IL-10 dampens TNF/inducible nitric oxide synthase-producing dendritic cell-mediated pathogenicity during parasitic infectionMartin Guilliams
Department of Molecular and Cellular Interactions, VIB, Brussels, Belgium
J Immunol 182:1107-18. 2009....
- T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient miceN J Davidson
DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304, USA
J Exp Med 184:241-51. 1996Mice rendered deficient in the production of interleukin 10 (IL-10-/-) develop a chronic inflammatory bowel disease (IBD) that predominates in the colon and shares histopathological features with human IBD...
- Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responsesD J Berg
Department of Immunology and Molecular Biology, DNAX Research Institute of Cellular and Molecular Biology, Palo Alto, California 94304, USA
J Clin Invest 98:1010-20. 1996..In 3-mo-old mutants, intestinal lesions were most severe in IL-10-/- 129/SvEv and IL-10-/- BALB/c strains, of intermediate severity in the IL-10-/- 129 x C57BL/6J outbreds, and least severe in the IL-10-/- C57BL/6J strain...
- Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulationAtsushi Mizoguchi
Immunopathology Unit, Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
Immunity 16:219-30. 2002..This study indicates that B cells, by producing cytokines such as IL-10, can act as regulatory cells in immunologically mediated inflammatory reactions...
- A pivotal role for galectin-1 in fetomaternal toleranceSandra M Blois
Charite, University Medicine Berlin, Biomedical Research Building, Campus Virchow, Augustenburger Platz 1, Berlin 13353, Germany
Nat Med 13:1450-7. 2007..Thus, Gal-1 is a pivotal regulator of fetomaternal tolerance that has potential therapeutic implications in threatened pregnancies...
- A heat shock protein gene (Hsp70.1) is critically involved in the generation of the immune response to myelin antigenMarcin P Mycko
Department of Neurology, Laboratory of Neuroimmunology, Medical University of Lodz, 22 Kopcinskiego Street, Lodz, Poland
Eur J Immunol 38:1999-2013. 2008....
- Selective down-regulation of neutrophil Mac-1 in endotoxemic hepatic microcirculation via IL-10Gustavo Batista Menezes
Calvin, Phoebe, and Joan Snyder Institute for Infection, Immunity, and Inflammation, University of Calgary, Alberta, Canada
J Immunol 183:7557-68. 2009..This may be a mechanism to keep neutrophils in sinusoids for intravascular trapping...
- Lessons from genetically engineered animal models. XII. IL-10-deficient (IL-10(-/-) mice and intestinal inflammationD M Rennick
DNAX Research Institute of Cellular and Molecular Biology, Palo Alto, California 94304, USA
Am J Physiol Gastrointest Liver Physiol 278:G829-33. 2000....
- IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-alpha production in macrophagesHirotaka Kuwata
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Osaka 565 0871, Japan
Blood 102:4123-9. 2003..These findings suggest that IL-10-induced Bcl-3 is required for suppression of TNF-alpha production in macrophages...
- Increased weight loss with reduced viral replication in interleukin-10 knock-out mice infected with murine cytomegalovirusO R Oakley
Department of Clinical Sciences, University of Kentucky, Lexington, KY 40536 0084, USA
Clin Exp Immunol 151:155-64. 2008..These data suggest that increased weight loss observed in IL-10 knock-out mice may be attributed to the uncontrolled production of proinflammatory cytokines, including IL-6...
- Quantitative polymerase chain reaction analysis reveals marked overexpression of interleukin-1 beta, interleukin-1 and interferon-gamma mRNA in the lymph nodes of lupus-prone miceG J Prud'homme
Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA
Mol Immunol 32:495-503. 1995..IL-1 beta, IFN gamma and IL-10 are pleiotropic cytokines with pro-inflammatory and B-cell stimulatory effects. These results point to certain cytokines as potential targets for immunotherapy in lupus...
- IL-10 deficit correlates with chronic, hypersplenomegaly syndrome in male CBA/J mice infected with Schistosoma mansoniS C Bosshardt
Immunology Branch, Centers for Disease Control and Prevention, USA Public Health Service, Atlanta, GA 30341, USA
Parasite Immunol 19:347-53. 1997..This association of low levels of antigen-induced IL-10 with severe pathology is consistent with the theory that IL-10 plays a role in the immunoregulation that occurs in chronic schistosomiasis...
- IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immune down-modulation of chronic diseaseT A Wynn
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 160:4473-80. 1998..We conclude that while IL-10 plays an important role in controlling acute granulomatous inflammation, it plays no essential role in the process of immune down-modulation in chronic schistosome infection...
- Antifungal type 1 responses are upregulated in IL-10-deficient miceG Del Sero
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy
Microbes Infect 1:1169-80. 1999..The resulting protective Th1 responses lead to a prompt reduction of fungal growth, thus preventing tissue destruction and lethal levels of proinflammatory cytokines...
- Role of endogenous IL-10 in LPS-induced STAT3 activation and IL-1 receptor antagonist gene expressionVirginia S Carl
University of Virginia Health System, Department of Medicine, Digestive Health Center of Excellence and Microbiology, Charlottesville, VA 22908 0708, USA
J Leukoc Biol 76:735-42. 2004..Together, these results demonstrate that endogenously produced IL-10 plays a significant role in LPS-induced sIL-1Ra gene expression via the activation of STAT3...
- Interleukin-10 induces uteroglobin-related protein (UGRP) 1 gene expression in lung epithelial cells through homeodomain transcription factor T/EBP/NKX2.1Achara Srisodsai
Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 279:54358-68. 2004..1-dependent pathway. The results further suggest that UGRP1 might be a target for IL-10 anti-inflammatory activities in the lung...
- Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shockMichael Hammer
Institute of Medical Microbiology, Immunology, and Hygiene, Technical University Munich, 81675 Munich, Germany
J Exp Med 203:15-20. 2006..These data together demonstrate a specific regulatory role of DUSP1 in controlling a subset of LPS-induced genes that determines the outcome of endotoxin shock...
- Induction of suppressor of cytokine signaling-1 by Toxoplasma gondii contributes to immune evasion in macrophages by blocking IFN-gamma signalingStefan Zimmermann
Institute of Medical Microbiology and Hygiene, Philipps University, Marburg, Germany
J Immunol 176:1840-7. 2006..gondii on IFN-gamma were diminished in macrophages from SOCS-1-/- mice. The results suggest that induction of SOCS proteins within phagocytes due to infection with T. gondii contributes to the parasite's immune evasion strategies...
- The required role of endogenously produced lipoxin A4 and annexin-1 for the production of IL-10 and inflammatory hyporesponsiveness in miceDanielle G Souza
Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
J Immunol 179:8533-43. 2007....
- Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1Elaine Y Chung
Department of Microbiology and Immunology, Medical College of Cornell University, New York, NY 10065, USA
Immunity 27:952-64. 2007..By using a reporter assay, we mapped the apoptotic-cell-response element (ACRE) in the human IL10 promoter and provide biochemical and physiological evidence that ACRE mediates the transcriptional activation of ..
- Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent mannerLauren W Collison
Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
J Immunol 182:6121-8. 2009..These data suggest that it is the induction of suppression, rather than the function of T(reg) that is obligatorily contact dependent...
- B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo functionMELANIE A RUFFNER
Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
Eur J Immunol 39:3084-90. 2009..We conclude that B7-1 and B7-2, but not PD-L1 and PD-L2, on IL-10-treated DC and DC-derived exosomes play a critical role in immunosuppressive functions of both DC and exosomes...
- Interleukin-10 mediated autoregulation of murine B-1 B-cells and its role in Borrelia hermsii infectionVishal Sindhava
Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America
PLoS ONE 5:e11445. 2010..This study described a novel autoregulatory property of B-1P cells mediated by B-1P cell derived IL-10, which may affect the function of B-1P cells in infection and autoimmunity...
- Induction of interleukin-10 in the T helper type 17 effector population by the G protein coupled estrogen receptor (GPER) agonist G-1Ryan L Brunsing
Department of Cell Biology and Physiology, University of New Mexico Health Science Center, Albuquerque, NM, USA
Immunology 134:93-106. 2011..These results demonstrate that G-1 acts directly on CD4(+) T cells, and to our knowledge provide the first example of a synthetic small molecule capable of eliciting IL-10 expression in Th17 or hybrid T-cell populations...
- Murine cytomegalovirus infection down-regulates MHC class II expression on macrophages by induction of IL-10S Redpath
Department of Immunology, Division of Virology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Immunol 162:6701-7. 1999..Altogether, our results demonstrate that viral induction of an IL-10 autocrine pathway plays an essential early role in selectively reducing MHC class II expression on the surface of APC prior to stimulation by IFN-gamma...
- Autocrine IL-10 impairs dendritic cell (DC)-derived immune responses to mycobacterial infection by suppressing DC trafficking to draining lymph nodes and local IL-12 productionCaroline Demangel
Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW, Australia
Eur J Immunol 32:994-1002. 2002....
- Cerebral edema and cerebral hemorrhages in interleukin-10-deficient mice infected with Plasmodium chabaudiLatifu A Sanni
Division of Parasitology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
Infect Immun 72:3054-8. 2004..Anti-tumor necrosis factor alpha treatment ameliorated both cerebral edema and hemorrhages, suggesting that proinflammatory responses contributed to cerebral complications in infected IL-10(-/-) mice...
- Interleukin 10 protects mice from lethal endotoxemiaM Howard
DNAX Research Institute, Palo Alto, California 94304
J Exp Med 177:1205-8. 1993b>Interleukin 10 (IL-10) decreases production of IL-1, IL-6, and tumor necrosis factor alpha (TNF-alpha) in vitro, and neutralization of IL-10 in mice leads to elevation of the same monokines...
- Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genesJ M Kim
Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304
J Immunol 148:3618-23. 1992..The mIL-10 gene was mapped to mouse chromosome 1 and the human IL-10 gene was also mapped to human chromosome 1...
- Interleukin-10 inhibition of the progression of established collagen-induced arthritisM Walmsley
Kennedy Institute of Rheumatology, London, England
Arthritis Rheum 39:495-503. 1996..The study was undertaken to establish whether IL-10 can ameliorate arthritis in the collagen-induced arthritis (CIA) model of RA...
- Studies with IL-10-/- mice: an overviewD M Rennick
DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304 1104, USA
J Leukoc Biol 61:389-96. 1997..whereby persistent stimulation by normal enteric antigens leads to the development of chronic enterocolitis in interleukin 10-deficient (IL-10-/-) mice...
- IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruziC A Hunter
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
J Immunol 158:3311-6. 1997..cruzi there is a critical requirement for IL-10 to prevent the development of a pathologic immune response associated with CD4+ T cells and overproduction of IL-12...
- Altered immune responses in interleukin 10 transgenic miceA Hagenbaugh
Molecular Biology Institute, Department of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
J Exp Med 185:2101-10. 1997..These mice will be useful in defining differences in inflammatory conditions and cellular immunity mediated by IL-10...
- The role of IL-10 in mouse hepatitis virus-induced demyelinating encephalomyelitisM T Lin
Department of Pathology, School of Medicine, University of Southern California, Los Angeles 90033, USA
Virology 245:270-80. 1998b>Interleukin 10 (IL-10) is an important anti-inflammatory cytokine. To examine its role in virus-induced encephalomyelitis, IL-10-deficient (IL-10 -/-) mice were infected with a neurotropic strain of mouse hepatitis virus (JHMV)...
- Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosisT K Tarrant
Laboratory of Immunology, National Institutes of Health, Bethesda, Maryland 20892, USA
J Exp Med 189:219-30. 1999....
- A transgenic model to analyze the immunoregulatory role of IL-10 secreted by antigen-presenting cellsH Groux
DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
J Immunol 162:1723-9. 1999..These results demonstrate, that, depending on the type of immune response, IL-10 can mediate immunosuppressive or immunostimulatory activities in vivo...
- Lack of IL-10 synthesis by murine alveolar macrophages upon lipopolysaccharide exposure. Comparison with peritoneal macrophagesL Salez
Unité Associée Institut Pasteur Institut National de la Santé et de la Recherche Médicale 485, Paris, France
J Leukoc Biol 67:545-52. 2000..The current findings describe a specific phenotype for murine alveolar macrophages during LPS-induced inflammation...
- Antibiotic therapy attenuates colitis in interleukin 10 gene-deficient miceK L Madsen
Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
Gastroenterology 118:1094-105. 2000..This study mapped the appearance of luminal colonic bacteria and, using antibiotic treatment, determined their association with colitis in IL-10 gene-deficient mice...
- Interleukin-10 and the interleukin-10 receptorK W Moore
Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304, USA
Annu Rev Immunol 19:683-765. 2001..This review highlights findings that have advanced our understanding of IL-10 and its receptor, as well as its in vivo function in health and disease...
- Interleukin-10-deficient mice and inflammatory bowel disease associated cancer developmentS Sturlan
Department of General Surgery, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
Carcinogenesis 22:665-71. 2001..Elevated TGF-beta1 plasma levels correspond to the high incidence of dysplasia and cancer. Normal expression of the TGF-beta II receptors hints at genetic alterations in other members of the TGF-beta receptor signal transduction pathway...
- IL-10-deficient B10.Q mice develop more severe collagen-induced arthritis, but are protected from arthritis induced with anti-type II collagen antibodies- Johansson AC
Section for Medical Inflammation Research, University of Lund, Lund, Sweden
J Immunol 167:3505-12. 2001..These data emphasize the importance of studying IL-10 in a defined genetic context in vivo, to understand its role in a complex disease like arthritis...
- Early enhanced Th1 response after Leishmania amazonensis infection of C57BL/6 interleukin-10-deficient mice does not lead to resolution of infectionDouglas E Jones
Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011, USA
Infect Immun 70:2151-8. 2002..These results indicate that although IL-10 plays a role in limiting the Th1 response during the acute infection phase, other immunomodulatory factors are responsible for limiting the Th1 response during the chronic phase...
- Autocrine deactivation of macrophages in transgenic mice constitutively overexpressing IL-10 under control of the human CD68 promoterRoland Lang
Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
J Immunol 168:3402-11. 2002....
- Immunostimulatory DNA ameliorates experimental and spontaneous murine colitisDaniel Rachmilewitz
Division of Medicine, Shaare Zedek Medical Center, Jerusalem, Israel
Gastroenterology 122:1428-41. 2002..We hypothesized that these combined effects of ISS-DNA could inhibit the damage to the colonic mucosa in chemically induced colitis and thereby limit subsequent intestinal inflammation...
- Regulatory role of interleukin-10 in experimental group B streptococcal arthritisManuela Puliti
Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
Infect Immun 70:2862-8. 2002..In conclusion, this study provides further information concerning the role of IL-10 in regulating the immune response and inflammation and calls attention to the potential therapeutic use of IL-10 in GBS arthritis...
- Expression of ICOS in vivo defines CD4+ effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10Max Löhning
Deutsches Rheumaforschungszentrum, Schumannstrasse 21 22, D 10117 Berlin, Germany
J Exp Med 197:181-93. 2003....
- Colitogenic Th1 cells are present in the antigen-experienced T cell pool in normal mice: control by CD4+ regulatory T cells and IL-10Chrystelle Asseman
La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
J Immunol 171:971-8. 2003....
- Bromelain Proteinase Activity in IBDLAURA HALE; Fiscal Year: 2006..They will thus strengthen the scientific knowledge base needed to inform the practice of complementary and alternative medicine. ..
- Novel Oral Adjuvant for Dental VaccinesLAURA HALE; Fiscal Year: 2005..abstract_text> ..
- Bromelain as a Biologically-Based Therapy for IBDLAURA HALE; Fiscal Year: 2005..This research will thus strengthen the biomedical research knowledge base needed to inform the practice of complementary and alternative medicine. ..
- Chemoprevention of IBD-Associated Colon CancerLaura P Hale; Fiscal Year: 2010..The proposed studies will further elucidate mechanisms that can lead to novel interventions to prevent IBD-associated colon cancers, providing great benefit to IBD patients and their families. ..
- Mast Cells and IBD PathogenesisLAURA HALE; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUMGEORGE DEEPE; Fiscal Year: 2007..abstract_text> ..
- Mechanisms of Immune Modulation by Abscisic AcidJosep Bassaganya Riera; Fiscal Year: 2010..The mechanistic understanding of the immune modulatory properties of botanicals such as ABA will aid in the development of more efficacious CAM approaches for modulating immune function and ameliorating infectious diseases. ..
- Defending Against Systemic MycosesGEORGE DEEPE; Fiscal Year: 2008..The collaborative and synergistic effort manifested by this group of investigators will provide new and exciting information regarding prevention and/or treatment of these problematic fungi. ..
- Regulation of Inflammation by Somatostatin via SSTR 2David Elliott; Fiscal Year: 2006..Macrophage SOM production is induced by LPS, IFN-?, IL 10, TNF-?, PgE2 and cAMP. Murine inflammatory T cells express only one type of SOM receptor, SSTR2...
- Novel Molecules that Define Viral PersistenceDavid Brooks; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- HOST FACTORS MEDIATE INVASION BY CAMPYLOBACTER JEJUNILINDA MANSFIELD; Fiscal Year: 2002..jejuni invasion is facilitated due to a direct effect of some secreted/excreted product of the worms, and 4) Determine what host cell genes are differentially expressed during C. jejuni invasion. ..
- Th1-to Th2 shift of HSP65 responses and atherogenesisYoshimi Shibata; Fiscal Year: 2005..Finally, we will determine if transfusion of fit-1 +marrow cells from HK-BCG treated WT donors will restore the Thl-to-Th2 shifts in 89Sr-treated WT recipients. ..
- Induction of hepatic tolerance to parasitic nematodesSusan Bliss; Fiscal Year: 2007..The research emphasis of the Institute is directed towards animal models of disease, providing a highly supportive environment for the applicant's career development. ..
- The Role of MerTK in Autoimmune DiabetesROLAND MICHAEL TISCH; Fiscal Year: 2010..In this way, the cellular and molecular contribution of MerTK in regulating ARC activation and effector function, and how these events shape p cell-specific T cell reactivity will be ascertained. ..
- Defining Antigen Induced Immunoregulation in T1 DiabetesRoland Tisch; Fiscal Year: 2008..abstract_text> ..
- HOST DEFENSES AGAINST PATHOGENIC E. coliLars Eckmann; Fiscal Year: 2007..coli, thus providing an important basis for designing immunization strategies against these pathogens. ..
- Role of Macrophage Arginase in Anti-Bacterial ImmunityPeter Murray; Fiscal Year: 2009..The outcomes of the proposed studies will reveal new elements of Arg I function and provide rationale for approaching Arg I as a target in inflammatory diseases. ..
- Immunology and Microbial Disease Training GrantDENNIS METZGER; Fiscal Year: 2006....
- HSP25 and HSP20 Regulation in Skeletal Muscle AdaptKIMBERLY HUEY; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- RAGE and modulation of tumor propertiesEmina Huang; Fiscal Year: 2006..A range of tools will be employed in order to accomplish these goals, both in in vitro assay systems, and in vivo, using RAGE null mice and a murine model of familial adenomatous polyposis (FAP). ..
- Vitamin D Regulation of Inflammatory Bowel DiseaseMARGHERITA CANTORNA; Fiscal Year: 2008..b>IL10 KO mice, which cannot respond to vitamin D (vitamin D receptor; VDR/IL10 double KO) develop a fulminating form of ..
- Analyzing and modulating immunoregulatory defects in autoimmune disease.Michele M Kosiewicz; Fiscal Year: 2010..abstract_text> ..
- Mechanisms of NSAID-induced inflammatory Bowel DiseaseDaniel Berg; Fiscal Year: 2007..iii) Mesenteric lymph nodes from IL10-/- mice with NSAID-induced IBD have increased numbers of activated dendritic cells, and (iv) NSAID-induced IBD in ..
- Natural Killer Cell Mediated Control of Vaccinia VirusAnthony French; Fiscal Year: 2007..The proposed work will occur under the mentorship of Dr. Wayne Yokoyama a recognized pioneer in the NK cell field who has successfully trained numerous graduate students and postdoctoral fellows. [unreadable] [unreadable]..
- Role of BCL-6 in Allergic Immune ResponsesAlexander Dent; Fiscal Year: 2005..These studies will also provide insight into the function of BCL6, which may help the treatment of B cell lymphoma. ..
- ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICSRICHARD ZAGER; Fiscal Year: 2001....
- CYTOKINE CONTROL OF RESPIRATORY IMMUNITYDENNIS METZGER; Fiscal Year: 2001..Thus, the application of IL-12 as a mucosal vaccine adjuvant may provide a novel approach for protection against respiratory diseases and could have immediate impact on human health. ..
- GASTRIC PRENEOPLASIA IN H FELIS INFECTED IL10 MICEDaniel Berg; Fiscal Year: 2002..the development of preneoplastic gastric epithelium, using a novel animal model, Helicobacter felis-infected interleukin 10-deficient mice (IL10-/-)...
- T CELL REACTIVITY TO GAD65 IN DIABETESRoland Tisch; Fiscal Year: 2002....
- LEISHMANIA INFECTION IN BALB/C IL4 NEG AND IL4R NEG MICENancy Noben Trauth; Fiscal Year: 2002..major parasites and will offer alternative theories to the Th1/Th2 paradigm in general. These studies also will lead to new interpretations of the action of anti-IL-4 treatment in vivo. ..
- GENISTEIN AS MODULATOR OF ANTIOXIDANT PROTEIN EXPRESSIONShiu Ming Kuo; Fiscal Year: 2002..These studies may also lead to the identification of a previous unknown pathway for Gn to regulate mammalian genes. ..
- IMMUNOMODULATORY STRATEGIES IN AUTOIMMUNE GASTRITISMICHELE KOSIEWICZ; Fiscal Year: 2002..This strategy may be used in conjunction with TGFbeta-treated APCs to successfully treat established autoimmune disease. ..
- The Use of VEE Replicons Encoding GAD65 to Treat IDDMRoland Tisch; Fiscal Year: 2002..This work should provide the foundation for possible future application of VEE replicon technology for the treatment of IDDM, and other tissue-specific autoimmune diseases. ..
- Requirements for regulatory T cell developmentMICHELE KOSIEWICZ; Fiscal Year: 2003..These experiments may determine the requirements for regulatory T cell development, and thereby, identify pathways that can be therapeutically manipulated to prevent and/or treat autoimmune diseases. ..
- The Upstate New York Immunology ConferenceDENNIS METZGER; Fiscal Year: 2003..abstract_text> ..
- VITAMIN D REGULATION OF TYPE-2 HELPER T CELL RESPONSESMARGHERITA CANTORNA; Fiscal Year: 2004..A better understanding of how vitamin D effectively blocks EAE is necessary for proper nutritional counseling and optimal treatment of multiple sclerosis patients. ..
- IL 12 RESPONSIVENESS DURING L AMAZONENSIS INFECTIONDouglas Jones; Fiscal Year: 2004..The efforts of this proposal will have direct application to the development of more effective immunomodulatory regimes for Leishmania and other infectious diseases. ..
- Sex-based differences in regulatory T cell responsesMICHELE KOSIEWICZ; Fiscal Year: 2004..The results of these studies will provide important information that can lead to the development of novel therapies for the prevention and treatment of autoimmune disease. ..
- 37th Annual Meeting of the Society for Leukocyte BiologyJoshua Fierer; Fiscal Year: 2004..We encourage students and other trainees to submit abstracts; the SLB gives awards for the best abstracts submitted by students. One of the main purposes of the meeting is to encourage young scientists. ..
- MUTANT NOD2 IN INTESTINAL INFLAMMATION AND HOST DISEASELars Eckmann; Fiscal Year: 2010..Together, the proposed studies are expected to yield important new insights into the physiological functions of mutant NOD2 as a mechanistic basis for designing new strategies in the treatment and prevention of CD. ..
- Role of IL-10 in Periodontal Bone DestructionHajime Sasaki; Fiscal Year: 2005..The long-term goal is to determine the preventive role of lL-10 in periodontitis, and to apply this information to the development of modulators that ameliorate this disease. ..
- IMMUNE ESCAPE MECHANISMS IN LEISHMANASISImtiaz Khan; Fiscal Year: 2006..These studies have implications for the development of therapies and vaccines directed toward Leishmania infections as well as the mechanisms that regulate Th1/Th2 cytokine development in vivo. ..
- IMMUNE RESPONSES TO SMALL INTESTINAL SUBMUCOSADENNIS METZGER; Fiscal Year: 2001..The results will provide important insight into the mechanisms responsible for successful xenogeneic transplantation and could lead to targeted cytokine therapies to prevent tissue rejection. ..
- MOUSE MODELS OF INTESTINAL INFECTION AND INFLAMMATIONLars Eckmann; Fiscal Year: 2008..abstract_text> ..
- Iron Therapy in Renal Disease: Potential ToxicitiesRICHARD ZAGER; Fiscal Year: 2008..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
- Role of Galectin-4 in ColitisAtsushi Mizoguchi; Fiscal Year: 2008..These studies will not only enhance understanding of the pathogenic mechanisms of IBD but also provide important information to develop new therapeutic approaches for human IBD. ..
- Immunological Basis for H. Pylori-Related MalignanciesMarygorret Obonyo; Fiscal Year: 2006..Under this award, the candidate will be able to develop this work into a productive project that will gain independent funding. ..
- Innate Immunity to Salmonella InfectionsJoshua Fierer; Fiscal Year: 2005..We will compare isogenic strains of salmonella that express either the group B or 0 LPS antigens in C3 deficient and neutropenic mice, in order to determine how the structure of the LPS affects virulence in mice. ..
- HOST IMMUNOMODULATION BY PARASITESRamaswamy Kalyanasundaram; Fiscal Year: 2004..Overall, the findings from these studies we believe might help improve per-cutaneous vaccination against this disease using defined candidate vaccine antigens against schistosomiasis. ..
- Role of SOCS proteins in host-pathogen responsesPeter Murray; Fiscal Year: 2003..PERFORMANCE SITE (S) (organization, city, state) St. Jude Children's Research Hospital, Memphis, TN . ..
- MULTIVALENT VACCINE FOR LYMPHATIC FILARIASISRamaswamy Kalyanasundaram; Fiscal Year: 2010..The proposed studies are based on solid preliminary data and are hypotheses driven. Results from these studies, we believe will advance our knowledge towards developing a defined vaccine against lymphatic filariasis in the human. ..