Il10

Summary

Gene Symbol: Il10
Description: interleukin 10
Alias: CSIF, Il-10, interleukin-10, cytokine synthesis inhibitory factor
Species: mouse

Top Publications

  1. ncbi IL-10 mediates susceptibility to Leishmania donovani infection
    M L Murphy
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Eur J Immunol 31:2848-56. 2001
  2. pmc CCR8 is expressed by antigen-elicited, IL-10-producing CD4+CD25+ T cells, which regulate Th2-mediated granuloma formation in mice
    Christine M Freeman
    Department of Pathology, University of Michigan Medical School, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI 48105, USA
    J Immunol 174:1962-70. 2005
  3. pmc Helminth infection can reduce insulitis and type 1 diabetes through CD25- and IL-10-independent mechanisms
    Qian Liu
    Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 S Orange Avenue, Newark, New Jersey 07103, USA
    Infect Immun 77:5347-58. 2009
  4. doi Endothelial cells augment the suppressive function of CD4+ CD25+ Foxp3+ regulatory T cells: involvement of programmed death-1 and IL-10
    Tanja Bedke
    Department of Dermatology, University Hospital Heidelberg, Heidelberg, Germany
    J Immunol 184:5562-70. 2010
  5. pmc IL-10 production differentially influences the magnitude, quality, and protective capacity of Th1 responses depending on the vaccine platform
    Patricia A Darrah
    Cellular Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 207:1421-33. 2010
  6. ncbi Interleukin-10-deficient mice develop chronic enterocolitis
    R Kuhn
    Institute for Genetics, University of Cologne, Federal Republic of Germany
    Cell 75:263-74. 1993
  7. ncbi B cells regulate autoimmunity by provision of IL-10
    Simon Fillatreau
    University of Edinburgh, Institute of Cell, Animal and Population Biology, King s Buildings West Mains Road, Edinburgh EH9 3JT, UK
    Nat Immunol 3:944-50. 2002
  8. doi Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1
    Olaf Gross
    Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
    Immunity 36:388-400. 2012
  9. pmc Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones
    D F Fiorentino
    Department of Immunology, DNAX Research Institute, Palo Alto, California 94304
    J Exp Med 170:2081-95. 1989
  10. pmc The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure
    Y Belkaid
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 4 Rm 126, Center Dr MSC 0425, Bethesda, MD 20892, USA
    J Exp Med 194:1497-506. 2001

Research Grants

  1. Bromelain Proteinase Activity in IBD
    LAURA HALE; Fiscal Year: 2006
  2. Novel Oral Adjuvant for Dental Vaccines
    LAURA HALE; Fiscal Year: 2005
  3. Bromelain as a Biologically-Based Therapy for IBD
    LAURA HALE; Fiscal Year: 2005
  4. Chemoprevention of IBD-Associated Colon Cancer
    Laura P Hale; Fiscal Year: 2010
  5. Mast Cells and IBD Pathogenesis
    LAURA HALE; Fiscal Year: 2007
  6. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
  7. Mechanisms of Immune Modulation by Abscisic Acid
    Josep Bassaganya Riera; Fiscal Year: 2010
  8. Defending Against Systemic Mycoses
    GEORGE DEEPE; Fiscal Year: 2008
  9. Regulation of Inflammation by Somatostatin via SSTR 2
    David Elliott; Fiscal Year: 2006
  10. Novel Molecules that Define Viral Persistence
    David Brooks; Fiscal Year: 2008

Detail Information

Publications202 found, 100 shown here

  1. ncbi IL-10 mediates susceptibility to Leishmania donovani infection
    M L Murphy
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
    Eur J Immunol 31:2848-56. 2001
    ..Together these studies demonstrate for the first time that IL-10 is a critical component of the immune response that inhibits resistance to L. donovani...
  2. pmc CCR8 is expressed by antigen-elicited, IL-10-producing CD4+CD25+ T cells, which regulate Th2-mediated granuloma formation in mice
    Christine M Freeman
    Department of Pathology, University of Michigan Medical School, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI 48105, USA
    J Immunol 174:1962-70. 2005
    ..Thus, IL-10-producing, CCR8+CD4+CD25+CD44+ T cells are generated during SEA challenge, which augment the Th2-mediated eosinophil-rich response to the parasite Ags...
  3. pmc Helminth infection can reduce insulitis and type 1 diabetes through CD25- and IL-10-independent mechanisms
    Qian Liu
    Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, 185 S Orange Avenue, Newark, New Jersey 07103, USA
    Infect Immun 77:5347-58. 2009
    ..These findings suggest that infection with H. polygyrus significantly inhibits T1D in NOD mice through CD25- and IL-10-independent mechanisms and also reduces the severity of T1D when administered late after the onset of insulitis...
  4. doi Endothelial cells augment the suppressive function of CD4+ CD25+ Foxp3+ regulatory T cells: involvement of programmed death-1 and IL-10
    Tanja Bedke
    Department of Dermatology, University Hospital Heidelberg, Heidelberg, Germany
    J Immunol 184:5562-70. 2010
    ..Therefore, one can speculate that T(reg) during transendothelial transmigration become "armed" for their suppressive function(s) to be carried out in peripheral tissues sites...
  5. pmc IL-10 production differentially influences the magnitude, quality, and protective capacity of Th1 responses depending on the vaccine platform
    Patricia A Darrah
    Cellular Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 207:1421-33. 2010
    ..Overall, we delineate distinct mechanisms by which vaccines elicit protective Th1 responses and underscore the importance of multifunctional CD4(+) T cells...
  6. ncbi Interleukin-10-deficient mice develop chronic enterocolitis
    R Kuhn
    Institute for Genetics, University of Cologne, Federal Republic of Germany
    Cell 75:263-74. 1993
    ..These results indicate that the bowel inflammation in the mutants originates from uncontrolled immune responses stimulated by enteric antigens and that IL-10 is an essential immunoregulator in the intestinal tract...
  7. ncbi B cells regulate autoimmunity by provision of IL-10
    Simon Fillatreau
    University of Edinburgh, Institute of Cell, Animal and Population Biology, King s Buildings West Mains Road, Edinburgh EH9 3JT, UK
    Nat Immunol 3:944-50. 2002
    ..B cells from recovered mice produced interleukin 10 (IL-10) in response to autoantigen...
  8. doi Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1
    Olaf Gross
    Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland
    Immunity 36:388-400. 2012
    ..Because inflammasomes contribute to the pathology of numerous chronic inflammatory diseases such as gout and diabetes, IL-1α antagonists may be beneficial in the treatment of these disorders...
  9. pmc Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones
    D F Fiorentino
    Department of Immunology, DNAX Research Institute, Palo Alto, California 94304
    J Exp Med 170:2081-95. 1989
    A cytokine synthesis inhibitory factor (CSIF) is secreted by Th2 clones in response to Con A or antigen stimulation, but is absent in supernatants from Con A-induced Th1 clones...
  10. pmc The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure
    Y Belkaid
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 4 Rm 126, Center Dr MSC 0425, Bethesda, MD 20892, USA
    J Exp Med 194:1497-506. 2001
    ....
  11. pmc The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27
    Lionel Apetoh
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Nat Immunol 11:854-61. 2010
    Type 1 regulatory T cells (Tr1 cells ) that produce interleukin 10 (IL-10) are instrumental in the prevention of tissue inflammation, autoimmunity and graft-versus-host disease...
  12. doi Type I interferon inhibits interleukin-1 production and inflammasome activation
    Greta Guarda
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Immunity 34:213-23. 2011
    ..Our findings may thus explain the effectiveness of type I IFN in the treatment of inflammatory diseases but also the observed "weakening" of the immune system after viral infection...
  13. pmc Posttranscriptional regulation of II10 gene expression allows natural killer cells to express immunoregulatory function
    Asher Maroof
    Immunology and Infection Unit, Hull York Medical School and Department of Biology, University of York, Wentworth Way, York YO10 5YW, UK
    Immunity 29:295-305. 2008
    ....
  14. pmc Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose
    Margarida Saraiva
    Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Immunity 31:209-19. 2009
    ..IL-10 expression also correlated with c-maf expression. Despite having distinct functions in protection against pathogens, all Th cells share the important task of controlling overexuberant immune responses by means of IL-10 production...
  15. doi Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10
    Juan M Ilarregui
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    Nat Immunol 10:981-91. 2009
    ..Our findings identify a tolerogenic circuit linking galectin-1 signaling, IL-27-producing DCs and IL-10-secreting T cells, which has broad therapeutic implications in immunopathology...
  16. pmc Autocrine regulation of pulmonary inflammation by effector T-cell derived IL-10 during infection with respiratory syncytial virus
    Jie Sun
    The Beirne B Carter Center for Immunology Research, The University of Virginia, Charlottesville, Virginia, United States of America
    PLoS Pathog 7:e1002173. 2011
    ..Our findings suggest a potentially critical role of effector T cell-derived IL-10 in controlling disease severity in clinical RSV infection...
  17. ncbi In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha
    R T Gazzinelli
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 157:798-805. 1996
    ..Together the data suggest that endogenous IL-10 synthesis plays an important role in vivo in down-regulating monokine and IFN-gamma responses to acute intracellular infection, thereby preventing host immunopathology...
  18. pmc Activating receptors promote NK cell expansion for maintenance, IL-10 production, and CD8 T cell regulation during viral infection
    Seung Hwan Lee
    Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    J Exp Med 206:2235-51. 2009
    ..The Ly49H-dependent protection mechanism delivered in the absence of Prf1 was a result of interleukin 10 production, by the sustained NK cells, to regulate the magnitude of CD8 T cell responses...
  19. ncbi A critical role for IL-10 in limiting inflammation during toxoplasmic encephalitis
    Emma H Wilson
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6008, USA
    J Neuroimmunol 165:63-74. 2005
    ..Together these results point to a vital role for IL-10 in the control of CD4(+) T cell mediated inflammation in the brain during TE...
  20. doi Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
    Katrin Kierdorf
    Department of Neuropathology, University of Freiburg, Freiburg, Germany
    Nat Neurosci 16:273-80. 2013
    ..Our data provide cellular and molecular insights into the origin and development of microglia...
  21. pmc Nonredundant roles for B cell-derived IL-10 in immune counter-regulation
    Rajat Madan
    Division of Molecular Immunology, Cincinnati Children s Hospital Research Foundation and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Immunol 183:2312-20. 2009
    ....
  22. pmc TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells
    Frank Kaiser
    Division of Immunoregulation, Medical Research Council National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    J Exp Med 206:1863-71. 2009
    ....
  23. pmc IL-10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral infection
    David G Brooks
    Department of Microbiology, Immunology and Molecular Genetics and the UCLA AIDS Institute, David Geffen School of Medicine, University of California Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:3018-23. 2010
    ..On the other hand, lack of IL-10 signaling did not impact memory CD8 T cell development. We propose that blockade of IL-10 may be an effective adjuvant to specifically enhance CD4 T cell immunity and protection following vaccination...
  24. pmc An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
    C Asseman
    Nuffield Department of Surgery, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom
    J Exp Med 190:995-1004. 1999
    ..These findings provide the first clear evidence that IL-10 plays a nonredundant role in the functioning of regulatory T cells that control inflammatory responses towards intestinal antigens...
  25. ncbi CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasis
    Antonella Mencacci
    Department of Experimental Medicine and Biochemical Science, University of Perugia, Perugia, Italy
    J Immunol 169:3180-90. 2002
    ..These data indicate that alternatively activated PMN expressing CD80 may adversely affect Th1-dependent resistance in fungal infections...
  26. pmc Increased inflammation, impaired bacterial clearance, and metabolic disruption after gram-negative sepsis in Mkp-1-deficient mice
    W Joshua Frazier
    Center for Perinatal Research, The Research Institute at Nationwide Children s Hospital, Columbus, OH 43205, USA
    J Immunol 183:7411-9. 2009
    ....
  27. pmc IL-10 restricts activation-induced death of NK cells during acute murine cytomegalovirus infection
    Maria A Stacey
    Department of Infection, Immunity and Biochemistry, School of Medicine, Cardiff University, Cardiff, CF14 4XN, United Kingdom
    J Immunol 187:2944-52. 2011
    ..Therefore, we conclude that IL-10 contributes to antiviral innate immunity during acute infection by restricting activation-induced death in NK cells...
  28. pmc Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis
    Brian D Gulbransen
    Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    Nat Med 18:600-4. 2012
    ..Targeting Panx1 represents a new neuroprotective strategy to ameliorate the progression of IBD-associated dysmotility...
  29. pmc Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis
    Masako Murai
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Immunol 10:1178-84. 2009
    ..Here we show that interleukin 10 (IL-10) produced by CD11b(+) myeloid cells in recombination-activating gene 1-deficient (Rag1(-/-)) recipient ..
  30. ncbi Tumor-induced interleukin-10 inhibits type 1 immune responses directed at a tumor antigen as well as a non-tumor antigen present at the tumor site
    B K Halak
    Kimmel Cancer Center, Division of Medical Oncology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Cancer Res 59:911-7. 1999
    ..These studies demonstrate that tumor-induced IL-10 can block the generation of a tumor-specific type 1 immune response as well as subvert attempts to elicit a type 1 immune response to a non-tumor antigen at the tumor site...
  31. doi Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model
    Marina C Pils
    Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Eur J Immunol 40:443-8. 2010
    ..In contrast, in an IL-10-regulated T-cell response to Trichuris muris infection, IL-10 acting on T cells or monocytes/macrophages/neutrophils is not critical for the control of the infection...
  32. doi Monocyte chemoattractant protein-1 contributes to gut homeostasis and intestinal inflammation by composition of IL-10-producing regulatory macrophage subset
    Yasuhiro Takada
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Immunol 184:2671-6. 2010
    ..Moreover, MCP-1-dependent LPM2 subset may play an important role in maintenance of gut homeostasis in the steady state, and in the termination of excess inflammatory responses in the intestine, by producing IL-10...
  33. ncbi Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals
    Andre Boonstra
    Division of Immunoregulation, National Institute for Medical Research, The Ridgeway, London NW7 1AA, United Kingdom
    J Immunol 177:7551-8. 2006
    ....
  34. ncbi Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse
    Masahito Kamanaka
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 25:941-52. 2006
    ..These findings highlight the intestine as a unique site for induction of IL-10-producing T cells, which play a critical role in the regulation of inflammation in the gut...
  35. ncbi Interleukin-4 but not interleukin-10 protects against spontaneous and recurrent type 1 diabetes by activated CD1d-restricted invariant natural killer T-cells
    Qing Sheng Mi
    Autoimmunity Diabetes Group, Robarts Research Institute, 1400 Western Road, London, Ontario N6G 2V4, Canada
    Diabetes 53:1303-10. 2004
    ..Our data identify an important role for IL-4 in the protection against type 1 diabetes by activated iNKT cells, and these findings have important implications for cytokine-based therapy of type 1 diabetes and islet transplantation...
  36. ncbi Mononuclear phagocyte-derived IL-10 suppresses the innate IL-12/IFN-gamma axis in lung-challenged aged mice
    Bo Chin Chiu
    Department of Cellular and Molecular Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 181:3156-66. 2008
    ..Our data identify a novel mechanism of age-associated immune deficiency...
  37. pmc Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production
    Jose M Gonzalez-Navajas
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 207:2799-807. 2010
    ..Our data identifies a new molecular pathway by which IL-1 signaling attenuates TLR9-mediated proinflammatory responses...
  38. pmc CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs
    Jie Sun
    The Beirne B Carter Center for Immunology Research, The University of Virginia, Charlottesville, Virginia, USA
    Nat Immunol 12:327-34. 2011
    ..These findings reveal a previously unrecognized pathway that coordinates signals derived from innate and helper T cells to control the production of a regulatory cytokine by CTLs during acute viral infection...
  39. pmc Regulatory T cells inhibit acute IFN-γ synthesis without blocking T-helper cell type 1 (Th1) differentiation via a compartmentalized requirement for IL-10
    Dorothy K Sojka
    The David H Smith Center for Vaccine Biology and Immunology, Aab Institute of Biomedical Sciences, Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 108:18336-41. 2011
    ..Interestingly, Tregs used different regulatory mechanisms to regulate IFN-γ (IL-10-dependent or -independent) subject to the target T-cell stage of activation and its tissue location...
  40. pmc Interleukin-10 promotes Mycobacterium tuberculosis disease progression in CBA/J mice
    Gillian L Beamer
    Center for Microbial Interface Biology, The Ohio State University, Columbus, OH 43210, USA
    J Immunol 181:5545-50. 2008
    ..Our results indicate that IL-10 promotes TB disease progression. These findings have important diagnostic and/or therapeutic implications for the prevention of reactivation TB in humans...
  41. pmc An anti-inflammatory role for carbon monoxide and heme oxygenase-1 in chronic Th2-mediated murine colitis
    Shehzad Z Sheikh
    Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    J Immunol 186:5506-13. 2011
    ....
  42. pmc Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation
    Fang Yan
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2576, USA
    J Clin Invest 114:1272-80. 2004
    ..These effects are reversed by WT, but not kinase-inactive, KSR1. We conclude that KSR1 has an essential protective role in the intestinal epithelial cell during inflammation through activation of cell survival pathways...
  43. doi TLR-2-activated B cells suppress Helicobacter-induced preneoplastic gastric immunopathology by inducing T regulatory-1 cells
    Ayca Sayi
    Institute of Molecular Cancer Research, University of Zurich, Zurich 8057, Switzerland
    J Immunol 186:878-90. 2011
    ....
  44. pmc Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis
    T Kasama
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA
    J Clin Invest 95:2868-76. 1995
    ..macrophage inflammatory protein 1 alpha (MIP-1 alpha) and macrophage inflammatory protein 2 (MIP-2), and interleukin 10 (IL-10) during the evolution of type II collagen-induced arthritis (CIA)...
  45. ncbi NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses
    Tomohiro Watanabe
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10 Room 11N238, 10 Center Drive, Bethesda, Maryland 20892, USA
    Nat Immunol 5:800-8. 2004
    ..Thus, CARD15 mutations may lead to disease by causing excessive T(H)1 responses...
  46. ncbi TLR-activated B cells suppress T cell-mediated autoimmunity
    Vicky Lampropoulou
    Deutsches Rheuma ForschungsZentrum, Berlin, Germany
    J Immunol 180:4763-73. 2008
    ..Altogether, our data indicate that B cells link recognition of microbial products via TLR to suppression of a T cell-mediated autoimmune disease...
  47. pmc IL-21 mediates suppressive effects via its induction of IL-10
    Rosanne Spolski
    Laboratory of Molecular Immunology and Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 182:2859-67. 2009
    ..Overall, our data indicate that IL-21 regulates immune responses at least in part by inducing IL-10 and reveal unanticipated immunosuppressive actions for this cytokine...
  48. ncbi 1,25-Dihydroxycholecalciferol prevents and ameliorates symptoms of experimental murine inflammatory bowel disease
    M T Cantorna
    Department of Nutrition, College of Health and Human Development, The Pennsylvania State University, University Park, PA 16802, USA
    J Nutr 130:2648-52. 2000
    ..1, 25-Dihydroxycholecalciferol treatment (0.2 microgram/d) for as little as 2 wk blocked the progression and ameliorated (P < 0.05) symptoms in IL-10 KO mice with already established IBD...
  49. pmc IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice
    Mark S Wilson
    Immunopathogenesis Section, Laboratory of Parasitic Diseases, and Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases NIAID, NIH, Bethesda, Maryland, USA
    J Clin Invest 117:2941-51. 2007
    ..Thus, IL-10 and IL-13Ralpha2 are both required to control chronic Th2-driven pathological responses...
  50. ncbi Chromatin-level regulation of the IL10 gene in T cells
    Sin Hyeog Im
    Department of Life Science, Gwangju Institute of Science and Technology, 1 Oryong dong, Puk ku, Gwangju 500 712, Korea
    J Biol Chem 279:46818-25. 2004
    The immunoregulatory cytokine interleukin 10 (IL-10) modulates the function of diverse immune and non-immune cells...
  51. ncbi Naturally occurring lung CD4(+)CD25(+) T cell regulation of airway allergic responses depends on IL-10 induction of TGF-beta
    Anthony Joetham
    Department of Pediatrics, Division of Cell Biology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 178:1433-42. 2007
    ..By analogy, anti-TGF-beta treatment reduced regulatory T cell activity. These data identify naturally occurring lung CD4(+)CD25(+) T cells as capable of regulating lung allergic responses in an IL-10- and TGF-beta-dependent manner...
  52. ncbi IL-10 and natural regulatory T cells: two independent anti-inflammatory mechanisms in herpes simplex virus-induced ocular immunopathology
    Pranita P Sarangi
    Comparative and Experimental Medicine Program, College of Veterinary Medicine, University of Tennessee, 1414 Cumberland Avenue, Knoxville, TN 37996, USA
    J Immunol 180:6297-306. 2008
    ..Our current investigations indicate that at least two independent anti-inflammatory mechanisms are involved in limiting the corneal lesions in SK, both of which may need to be modulated to control SK therapeutically...
  53. doi MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophages
    Joanne Darragh
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 425:595-602. 2010
    ..MSKs therefore act as important negative regulators of inflammation following TLR activation...
  54. ncbi The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells
    Matthias Hesse
    Laboratories of Parasitic Diseases and Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 172:3157-66. 2004
    ..Thus, innate effectors and regulatory T cells producing IL-10 cooperate to reduce morbidity and prolong survival in schistosomiasis...
  55. ncbi IL-10 dampens TNF/inducible nitric oxide synthase-producing dendritic cell-mediated pathogenicity during parasitic infection
    Martin Guilliams
    Department of Molecular and Cellular Interactions, VIB, Brussels, Belgium
    J Immunol 182:1107-18. 2009
    ....
  56. pmc T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice
    N J Davidson
    DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304, USA
    J Exp Med 184:241-51. 1996
    Mice rendered deficient in the production of interleukin 10 (IL-10-/-) develop a chronic inflammatory bowel disease (IBD) that predominates in the colon and shares histopathological features with human IBD...
  57. pmc Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses
    D J Berg
    Department of Immunology and Molecular Biology, DNAX Research Institute of Cellular and Molecular Biology, Palo Alto, California 94304, USA
    J Clin Invest 98:1010-20. 1996
    ..In 3-mo-old mutants, intestinal lesions were most severe in IL-10-/- 129/SvEv and IL-10-/- BALB/c strains, of intermediate severity in the IL-10-/- 129 x C57BL/6J outbreds, and least severe in the IL-10-/- C57BL/6J strain...
  58. ncbi Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation
    Atsushi Mizoguchi
    Immunopathology Unit, Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Immunity 16:219-30. 2002
    ..This study indicates that B cells, by producing cytokines such as IL-10, can act as regulatory cells in immunologically mediated inflammatory reactions...
  59. ncbi A pivotal role for galectin-1 in fetomaternal tolerance
    Sandra M Blois
    Charite, University Medicine Berlin, Biomedical Research Building, Campus Virchow, Augustenburger Platz 1, Berlin 13353, Germany
    Nat Med 13:1450-7. 2007
    ..Thus, Gal-1 is a pivotal regulator of fetomaternal tolerance that has potential therapeutic implications in threatened pregnancies...
  60. doi A heat shock protein gene (Hsp70.1) is critically involved in the generation of the immune response to myelin antigen
    Marcin P Mycko
    Department of Neurology, Laboratory of Neuroimmunology, Medical University of Lodz, 22 Kopcinskiego Street, Lodz, Poland
    Eur J Immunol 38:1999-2013. 2008
    ....
  61. doi Selective down-regulation of neutrophil Mac-1 in endotoxemic hepatic microcirculation via IL-10
    Gustavo Batista Menezes
    Calvin, Phoebe, and Joan Snyder Institute for Infection, Immunity, and Inflammation, University of Calgary, Alberta, Canada
    J Immunol 183:7557-68. 2009
    ..This may be a mechanism to keep neutrophils in sinusoids for intravascular trapping...
  62. ncbi Lessons from genetically engineered animal models. XII. IL-10-deficient (IL-10(-/-) mice and intestinal inflammation
    D M Rennick
    DNAX Research Institute of Cellular and Molecular Biology, Palo Alto, California 94304, USA
    Am J Physiol Gastrointest Liver Physiol 278:G829-33. 2000
    ....
  63. ncbi IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-alpha production in macrophages
    Hirotaka Kuwata
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Osaka 565 0871, Japan
    Blood 102:4123-9. 2003
    ..These findings suggest that IL-10-induced Bcl-3 is required for suppression of TNF-alpha production in macrophages...
  64. pmc Increased weight loss with reduced viral replication in interleukin-10 knock-out mice infected with murine cytomegalovirus
    O R Oakley
    Department of Clinical Sciences, University of Kentucky, Lexington, KY 40536 0084, USA
    Clin Exp Immunol 151:155-64. 2008
    ..These data suggest that increased weight loss observed in IL-10 knock-out mice may be attributed to the uncontrolled production of proinflammatory cytokines, including IL-6...
  65. ncbi Quantitative polymerase chain reaction analysis reveals marked overexpression of interleukin-1 beta, interleukin-1 and interferon-gamma mRNA in the lymph nodes of lupus-prone mice
    G J Prud'homme
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Immunol 32:495-503. 1995
    ..IL-1 beta, IFN gamma and IL-10 are pleiotropic cytokines with pro-inflammatory and B-cell stimulatory effects. These results point to certain cytokines as potential targets for immunotherapy in lupus...
  66. ncbi IL-10 deficit correlates with chronic, hypersplenomegaly syndrome in male CBA/J mice infected with Schistosoma mansoni
    S C Bosshardt
    Immunology Branch, Centers for Disease Control and Prevention, USA Public Health Service, Atlanta, GA 30341, USA
    Parasite Immunol 19:347-53. 1997
    ..This association of low levels of antigen-induced IL-10 with severe pathology is consistent with the theory that IL-10 plays a role in the immunoregulation that occurs in chronic schistosomiasis...
  67. ncbi IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immune down-modulation of chronic disease
    T A Wynn
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 160:4473-80. 1998
    ..We conclude that while IL-10 plays an important role in controlling acute granulomatous inflammation, it plays no essential role in the process of immune down-modulation in chronic schistosome infection...
  68. ncbi Antifungal type 1 responses are upregulated in IL-10-deficient mice
    G Del Sero
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy
    Microbes Infect 1:1169-80. 1999
    ..The resulting protective Th1 responses lead to a prompt reduction of fungal growth, thus preventing tissue destruction and lethal levels of proinflammatory cytokines...
  69. ncbi Role of endogenous IL-10 in LPS-induced STAT3 activation and IL-1 receptor antagonist gene expression
    Virginia S Carl
    University of Virginia Health System, Department of Medicine, Digestive Health Center of Excellence and Microbiology, Charlottesville, VA 22908 0708, USA
    J Leukoc Biol 76:735-42. 2004
    ..Together, these results demonstrate that endogenously produced IL-10 plays a significant role in LPS-induced sIL-1Ra gene expression via the activation of STAT3...
  70. ncbi Interleukin-10 induces uteroglobin-related protein (UGRP) 1 gene expression in lung epithelial cells through homeodomain transcription factor T/EBP/NKX2.1
    Achara Srisodsai
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:54358-68. 2004
    ..1-dependent pathway. The results further suggest that UGRP1 might be a target for IL-10 anti-inflammatory activities in the lung...
  71. pmc Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock
    Michael Hammer
    Institute of Medical Microbiology, Immunology, and Hygiene, Technical University Munich, 81675 Munich, Germany
    J Exp Med 203:15-20. 2006
    ..These data together demonstrate a specific regulatory role of DUSP1 in controlling a subset of LPS-induced genes that determines the outcome of endotoxin shock...
  72. ncbi Induction of suppressor of cytokine signaling-1 by Toxoplasma gondii contributes to immune evasion in macrophages by blocking IFN-gamma signaling
    Stefan Zimmermann
    Institute of Medical Microbiology and Hygiene, Philipps University, Marburg, Germany
    J Immunol 176:1840-7. 2006
    ..gondii on IFN-gamma were diminished in macrophages from SOCS-1-/- mice. The results suggest that induction of SOCS proteins within phagocytes due to infection with T. gondii contributes to the parasite's immune evasion strategies...
  73. ncbi The required role of endogenously produced lipoxin A4 and annexin-1 for the production of IL-10 and inflammatory hyporesponsiveness in mice
    Danielle G Souza
    Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    J Immunol 179:8533-43. 2007
    ....
  74. pmc Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1
    Elaine Y Chung
    Department of Microbiology and Immunology, Medical College of Cornell University, New York, NY 10065, USA
    Immunity 27:952-64. 2007
    ..By using a reporter assay, we mapped the apoptotic-cell-response element (ACRE) in the human IL10 promoter and provide biochemical and physiological evidence that ACRE mediates the transcriptional activation of ..
  75. pmc Regulatory T cell suppression is potentiated by target T cells in a cell contact, IL-35- and IL-10-dependent manner
    Lauren W Collison
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105 3678, USA
    J Immunol 182:6121-8. 2009
    ..These data suggest that it is the induction of suppression, rather than the function of T(reg) that is obligatorily contact dependent...
  76. pmc B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function
    MELANIE A RUFFNER
    Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Eur J Immunol 39:3084-90. 2009
    ..We conclude that B7-1 and B7-2, but not PD-L1 and PD-L2, on IL-10-treated DC and DC-derived exosomes play a critical role in immunosuppressive functions of both DC and exosomes...
  77. pmc Interleukin-10 mediated autoregulation of murine B-1 B-cells and its role in Borrelia hermsii infection
    Vishal Sindhava
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America
    PLoS ONE 5:e11445. 2010
    ..This study described a novel autoregulatory property of B-1P cells mediated by B-1P cell derived IL-10, which may affect the function of B-1P cells in infection and autoimmunity...
  78. pmc Induction of interleukin-10 in the T helper type 17 effector population by the G protein coupled estrogen receptor (GPER) agonist G-1
    Ryan L Brunsing
    Department of Cell Biology and Physiology, University of New Mexico Health Science Center, Albuquerque, NM, USA
    Immunology 134:93-106. 2011
    ..These results demonstrate that G-1 acts directly on CD4(+) T cells, and to our knowledge provide the first example of a synthetic small molecule capable of eliciting IL-10 expression in Th17 or hybrid T-cell populations...
  79. ncbi Murine cytomegalovirus infection down-regulates MHC class II expression on macrophages by induction of IL-10
    S Redpath
    Department of Immunology, Division of Virology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 162:6701-7. 1999
    ..Altogether, our results demonstrate that viral induction of an IL-10 autocrine pathway plays an essential early role in selectively reducing MHC class II expression on the surface of APC prior to stimulation by IFN-gamma...
  80. ncbi Autocrine IL-10 impairs dendritic cell (DC)-derived immune responses to mycobacterial infection by suppressing DC trafficking to draining lymph nodes and local IL-12 production
    Caroline Demangel
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW, Australia
    Eur J Immunol 32:994-1002. 2002
    ....
  81. pmc Cerebral edema and cerebral hemorrhages in interleukin-10-deficient mice infected with Plasmodium chabaudi
    Latifu A Sanni
    Division of Parasitology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Infect Immun 72:3054-8. 2004
    ..Anti-tumor necrosis factor alpha treatment ameliorated both cerebral edema and hemorrhages, suggesting that proinflammatory responses contributed to cerebral complications in infected IL-10(-/-) mice...
  82. pmc Interleukin 10 protects mice from lethal endotoxemia
    M Howard
    DNAX Research Institute, Palo Alto, California 94304
    J Exp Med 177:1205-8. 1993
    b>Interleukin 10 (IL-10) decreases production of IL-1, IL-6, and tumor necrosis factor alpha (TNF-alpha) in vitro, and neutralization of IL-10 in mice leads to elevation of the same monokines...
  83. ncbi Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes
    J M Kim
    Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304
    J Immunol 148:3618-23. 1992
    ..The mIL-10 gene was mapped to mouse chromosome 1 and the human IL-10 gene was also mapped to human chromosome 1...
  84. ncbi Interleukin-10 inhibition of the progression of established collagen-induced arthritis
    M Walmsley
    Kennedy Institute of Rheumatology, London, England
    Arthritis Rheum 39:495-503. 1996
    ..The study was undertaken to establish whether IL-10 can ameliorate arthritis in the collagen-induced arthritis (CIA) model of RA...
  85. ncbi Studies with IL-10-/- mice: an overview
    D M Rennick
    DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304 1104, USA
    J Leukoc Biol 61:389-96. 1997
    ..whereby persistent stimulation by normal enteric antigens leads to the development of chronic enterocolitis in interleukin 10-deficient (IL-10-/-) mice...
  86. ncbi IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi
    C A Hunter
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA
    J Immunol 158:3311-6. 1997
    ..cruzi there is a critical requirement for IL-10 to prevent the development of a pathologic immune response associated with CD4+ T cells and overproduction of IL-12...
  87. pmc Altered immune responses in interleukin 10 transgenic mice
    A Hagenbaugh
    Molecular Biology Institute, Department of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Exp Med 185:2101-10. 1997
    ..These mice will be useful in defining differences in inflammatory conditions and cellular immunity mediated by IL-10...
  88. ncbi The role of IL-10 in mouse hepatitis virus-induced demyelinating encephalomyelitis
    M T Lin
    Department of Pathology, School of Medicine, University of Southern California, Los Angeles 90033, USA
    Virology 245:270-80. 1998
    b>Interleukin 10 (IL-10) is an important anti-inflammatory cytokine. To examine its role in virus-induced encephalomyelitis, IL-10-deficient (IL-10 -/-) mice were infected with a neurotropic strain of mouse hepatitis virus (JHMV)...
  89. pmc Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis
    T K Tarrant
    Laboratory of Immunology, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 189:219-30. 1999
    ....
  90. ncbi A transgenic model to analyze the immunoregulatory role of IL-10 secreted by antigen-presenting cells
    H Groux
    DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304, USA
    J Immunol 162:1723-9. 1999
    ..These results demonstrate, that, depending on the type of immune response, IL-10 can mediate immunosuppressive or immunostimulatory activities in vivo...
  91. ncbi Lack of IL-10 synthesis by murine alveolar macrophages upon lipopolysaccharide exposure. Comparison with peritoneal macrophages
    L Salez
    Unité Associée Institut Pasteur Institut National de la Santé et de la Recherche Médicale 485, Paris, France
    J Leukoc Biol 67:545-52. 2000
    ..The current findings describe a specific phenotype for murine alveolar macrophages during LPS-induced inflammation...
  92. ncbi Antibiotic therapy attenuates colitis in interleukin 10 gene-deficient mice
    K L Madsen
    Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Gastroenterology 118:1094-105. 2000
    ..This study mapped the appearance of luminal colonic bacteria and, using antibiotic treatment, determined their association with colitis in IL-10 gene-deficient mice...
  93. ncbi Interleukin-10 and the interleukin-10 receptor
    K W Moore
    Department of Molecular Biology, DNAX Research Institute of Molecular and Cellular Biology Inc, Palo Alto, California 94304, USA
    Annu Rev Immunol 19:683-765. 2001
    ..This review highlights findings that have advanced our understanding of IL-10 and its receptor, as well as its in vivo function in health and disease...
  94. ncbi Interleukin-10-deficient mice and inflammatory bowel disease associated cancer development
    S Sturlan
    Department of General Surgery, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Carcinogenesis 22:665-71. 2001
    ..Elevated TGF-beta1 plasma levels correspond to the high incidence of dysplasia and cancer. Normal expression of the TGF-beta II receptors hints at genetic alterations in other members of the TGF-beta receptor signal transduction pathway...
  95. ncbi IL-10-deficient B10.Q mice develop more severe collagen-induced arthritis, but are protected from arthritis induced with anti-type II collagen antibodies
    - Johansson AC
    Section for Medical Inflammation Research, University of Lund, Lund, Sweden
    J Immunol 167:3505-12. 2001
    ..These data emphasize the importance of studying IL-10 in a defined genetic context in vivo, to understand its role in a complex disease like arthritis...
  96. pmc Early enhanced Th1 response after Leishmania amazonensis infection of C57BL/6 interleukin-10-deficient mice does not lead to resolution of infection
    Douglas E Jones
    Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011, USA
    Infect Immun 70:2151-8. 2002
    ..These results indicate that although IL-10 plays a role in limiting the Th1 response during the acute infection phase, other immunomodulatory factors are responsible for limiting the Th1 response during the chronic phase...
  97. ncbi Autocrine deactivation of macrophages in transgenic mice constitutively overexpressing IL-10 under control of the human CD68 promoter
    Roland Lang
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 168:3402-11. 2002
    ....
  98. ncbi Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis
    Daniel Rachmilewitz
    Division of Medicine, Shaare Zedek Medical Center, Jerusalem, Israel
    Gastroenterology 122:1428-41. 2002
    ..We hypothesized that these combined effects of ISS-DNA could inhibit the damage to the colonic mucosa in chemically induced colitis and thereby limit subsequent intestinal inflammation...
  99. pmc Regulatory role of interleukin-10 in experimental group B streptococcal arthritis
    Manuela Puliti
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Infect Immun 70:2862-8. 2002
    ..In conclusion, this study provides further information concerning the role of IL-10 in regulating the immune response and inflammation and calls attention to the potential therapeutic use of IL-10 in GBS arthritis...
  100. pmc Expression of ICOS in vivo defines CD4+ effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10
    Max Löhning
    Deutsches Rheumaforschungszentrum, Schumannstrasse 21 22, D 10117 Berlin, Germany
    J Exp Med 197:181-93. 2003
    ....
  101. ncbi Colitogenic Th1 cells are present in the antigen-experienced T cell pool in normal mice: control by CD4+ regulatory T cells and IL-10
    Chrystelle Asseman
    La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 171:971-8. 2003
    ....

Research Grants52

  1. Bromelain Proteinase Activity in IBD
    LAURA HALE; Fiscal Year: 2006
    ..They will thus strengthen the scientific knowledge base needed to inform the practice of complementary and alternative medicine. ..
  2. Novel Oral Adjuvant for Dental Vaccines
    LAURA HALE; Fiscal Year: 2005
    ..abstract_text> ..
  3. Bromelain as a Biologically-Based Therapy for IBD
    LAURA HALE; Fiscal Year: 2005
    ..This research will thus strengthen the biomedical research knowledge base needed to inform the practice of complementary and alternative medicine. ..
  4. Chemoprevention of IBD-Associated Colon Cancer
    Laura P Hale; Fiscal Year: 2010
    ..The proposed studies will further elucidate mechanisms that can lead to novel interventions to prevent IBD-associated colon cancers, providing great benefit to IBD patients and their families. ..
  5. Mast Cells and IBD Pathogenesis
    LAURA HALE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  6. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
    ..abstract_text> ..
  7. Mechanisms of Immune Modulation by Abscisic Acid
    Josep Bassaganya Riera; Fiscal Year: 2010
    ..The mechanistic understanding of the immune modulatory properties of botanicals such as ABA will aid in the development of more efficacious CAM approaches for modulating immune function and ameliorating infectious diseases. ..
  8. Defending Against Systemic Mycoses
    GEORGE DEEPE; Fiscal Year: 2008
    ..The collaborative and synergistic effort manifested by this group of investigators will provide new and exciting information regarding prevention and/or treatment of these problematic fungi. ..
  9. Regulation of Inflammation by Somatostatin via SSTR 2
    David Elliott; Fiscal Year: 2006
    ..Macrophage SOM production is induced by LPS, IFN-?, IL 10, TNF-?, PgE2 and cAMP. Murine inflammatory T cells express only one type of SOM receptor, SSTR2...
  10. Novel Molecules that Define Viral Persistence
    David Brooks; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  11. HOST FACTORS MEDIATE INVASION BY CAMPYLOBACTER JEJUNI
    LINDA MANSFIELD; Fiscal Year: 2002
    ..jejuni invasion is facilitated due to a direct effect of some secreted/excreted product of the worms, and 4) Determine what host cell genes are differentially expressed during C. jejuni invasion. ..
  12. Th1-to Th2 shift of HSP65 responses and atherogenesis
    Yoshimi Shibata; Fiscal Year: 2005
    ..Finally, we will determine if transfusion of fit-1 +marrow cells from HK-BCG treated WT donors will restore the Thl-to-Th2 shifts in 89Sr-treated WT recipients. ..
  13. Induction of hepatic tolerance to parasitic nematodes
    Susan Bliss; Fiscal Year: 2007
    ..The research emphasis of the Institute is directed towards animal models of disease, providing a highly supportive environment for the applicant's career development. ..
  14. The Role of MerTK in Autoimmune Diabetes
    ROLAND MICHAEL TISCH; Fiscal Year: 2010
    ..In this way, the cellular and molecular contribution of MerTK in regulating ARC activation and effector function, and how these events shape p cell-specific T cell reactivity will be ascertained. ..
  15. Defining Antigen Induced Immunoregulation in T1 Diabetes
    Roland Tisch; Fiscal Year: 2008
    ..abstract_text> ..
  16. HOST DEFENSES AGAINST PATHOGENIC E. coli
    Lars Eckmann; Fiscal Year: 2007
    ..coli, thus providing an important basis for designing immunization strategies against these pathogens. ..
  17. Role of Macrophage Arginase in Anti-Bacterial Immunity
    Peter Murray; Fiscal Year: 2009
    ..The outcomes of the proposed studies will reveal new elements of Arg I function and provide rationale for approaching Arg I as a target in inflammatory diseases. ..
  18. Immunology and Microbial Disease Training Grant
    DENNIS METZGER; Fiscal Year: 2006
    ....
  19. HSP25 and HSP20 Regulation in Skeletal Muscle Adapt
    KIMBERLY HUEY; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  20. RAGE and modulation of tumor properties
    Emina Huang; Fiscal Year: 2006
    ..A range of tools will be employed in order to accomplish these goals, both in in vitro assay systems, and in vivo, using RAGE null mice and a murine model of familial adenomatous polyposis (FAP). ..
  21. Vitamin D Regulation of Inflammatory Bowel Disease
    MARGHERITA CANTORNA; Fiscal Year: 2008
    ..b>IL10 KO mice, which cannot respond to vitamin D (vitamin D receptor; VDR/IL10 double KO) develop a fulminating form of ..
  22. Analyzing and modulating immunoregulatory defects in autoimmune disease.
    Michele M Kosiewicz; Fiscal Year: 2010
    ..abstract_text> ..
  23. Mechanisms of NSAID-induced inflammatory Bowel Disease
    Daniel Berg; Fiscal Year: 2007
    ..iii) Mesenteric lymph nodes from IL10-/- mice with NSAID-induced IBD have increased numbers of activated dendritic cells, and (iv) NSAID-induced IBD in ..
  24. Natural Killer Cell Mediated Control of Vaccinia Virus
    Anthony French; Fiscal Year: 2007
    ..The proposed work will occur under the mentorship of Dr. Wayne Yokoyama a recognized pioneer in the NK cell field who has successfully trained numerous graduate students and postdoctoral fellows. [unreadable] [unreadable]..
  25. Role of BCL-6 in Allergic Immune Responses
    Alexander Dent; Fiscal Year: 2005
    ..These studies will also provide insight into the function of BCL6, which may help the treatment of B cell lymphoma. ..
  26. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  27. CYTOKINE CONTROL OF RESPIRATORY IMMUNITY
    DENNIS METZGER; Fiscal Year: 2001
    ..Thus, the application of IL-12 as a mucosal vaccine adjuvant may provide a novel approach for protection against respiratory diseases and could have immediate impact on human health. ..
  28. GASTRIC PRENEOPLASIA IN H FELIS INFECTED IL10 MICE
    Daniel Berg; Fiscal Year: 2002
    ..the development of preneoplastic gastric epithelium, using a novel animal model, Helicobacter felis-infected interleukin 10-deficient mice (IL10-/-)...
  29. T CELL REACTIVITY TO GAD65 IN DIABETES
    Roland Tisch; Fiscal Year: 2002
    ....
  30. LEISHMANIA INFECTION IN BALB/C IL4 NEG AND IL4R NEG MICE
    Nancy Noben Trauth; Fiscal Year: 2002
    ..major parasites and will offer alternative theories to the Th1/Th2 paradigm in general. These studies also will lead to new interpretations of the action of anti-IL-4 treatment in vivo. ..
  31. GENISTEIN AS MODULATOR OF ANTIOXIDANT PROTEIN EXPRESSION
    Shiu Ming Kuo; Fiscal Year: 2002
    ..These studies may also lead to the identification of a previous unknown pathway for Gn to regulate mammalian genes. ..
  32. IMMUNOMODULATORY STRATEGIES IN AUTOIMMUNE GASTRITIS
    MICHELE KOSIEWICZ; Fiscal Year: 2002
    ..This strategy may be used in conjunction with TGFbeta-treated APCs to successfully treat established autoimmune disease. ..
  33. The Use of VEE Replicons Encoding GAD65 to Treat IDDM
    Roland Tisch; Fiscal Year: 2002
    ..This work should provide the foundation for possible future application of VEE replicon technology for the treatment of IDDM, and other tissue-specific autoimmune diseases. ..
  34. Requirements for regulatory T cell development
    MICHELE KOSIEWICZ; Fiscal Year: 2003
    ..These experiments may determine the requirements for regulatory T cell development, and thereby, identify pathways that can be therapeutically manipulated to prevent and/or treat autoimmune diseases. ..
  35. The Upstate New York Immunology Conference
    DENNIS METZGER; Fiscal Year: 2003
    ..abstract_text> ..
  36. VITAMIN D REGULATION OF TYPE-2 HELPER T CELL RESPONSES
    MARGHERITA CANTORNA; Fiscal Year: 2004
    ..A better understanding of how vitamin D effectively blocks EAE is necessary for proper nutritional counseling and optimal treatment of multiple sclerosis patients. ..
  37. IL 12 RESPONSIVENESS DURING L AMAZONENSIS INFECTION
    Douglas Jones; Fiscal Year: 2004
    ..The efforts of this proposal will have direct application to the development of more effective immunomodulatory regimes for Leishmania and other infectious diseases. ..
  38. Sex-based differences in regulatory T cell responses
    MICHELE KOSIEWICZ; Fiscal Year: 2004
    ..The results of these studies will provide important information that can lead to the development of novel therapies for the prevention and treatment of autoimmune disease. ..
  39. 37th Annual Meeting of the Society for Leukocyte Biology
    Joshua Fierer; Fiscal Year: 2004
    ..We encourage students and other trainees to submit abstracts; the SLB gives awards for the best abstracts submitted by students. One of the main purposes of the meeting is to encourage young scientists. ..
  40. MUTANT NOD2 IN INTESTINAL INFLAMMATION AND HOST DISEASE
    Lars Eckmann; Fiscal Year: 2010
    ..Together, the proposed studies are expected to yield important new insights into the physiological functions of mutant NOD2 as a mechanistic basis for designing new strategies in the treatment and prevention of CD. ..
  41. Role of IL-10 in Periodontal Bone Destruction
    Hajime Sasaki; Fiscal Year: 2005
    ..The long-term goal is to determine the preventive role of lL-10 in periodontitis, and to apply this information to the development of modulators that ameliorate this disease. ..
  42. IMMUNE ESCAPE MECHANISMS IN LEISHMANASIS
    Imtiaz Khan; Fiscal Year: 2006
    ..These studies have implications for the development of therapies and vaccines directed toward Leishmania infections as well as the mechanisms that regulate Th1/Th2 cytokine development in vivo. ..
  43. IMMUNE RESPONSES TO SMALL INTESTINAL SUBMUCOSA
    DENNIS METZGER; Fiscal Year: 2001
    ..The results will provide important insight into the mechanisms responsible for successful xenogeneic transplantation and could lead to targeted cytokine therapies to prevent tissue rejection. ..
  44. MOUSE MODELS OF INTESTINAL INFECTION AND INFLAMMATION
    Lars Eckmann; Fiscal Year: 2008
    ..abstract_text> ..
  45. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2008
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
  46. Role of Galectin-4 in Colitis
    Atsushi Mizoguchi; Fiscal Year: 2008
    ..These studies will not only enhance understanding of the pathogenic mechanisms of IBD but also provide important information to develop new therapeutic approaches for human IBD. ..
  47. Immunological Basis for H. Pylori-Related Malignancies
    Marygorret Obonyo; Fiscal Year: 2006
    ..Under this award, the candidate will be able to develop this work into a productive project that will gain independent funding. ..
  48. Innate Immunity to Salmonella Infections
    Joshua Fierer; Fiscal Year: 2005
    ..We will compare isogenic strains of salmonella that express either the group B or 0 LPS antigens in C3 deficient and neutropenic mice, in order to determine how the structure of the LPS affects virulence in mice. ..
  49. HOST IMMUNOMODULATION BY PARASITES
    Ramaswamy Kalyanasundaram; Fiscal Year: 2004
    ..Overall, the findings from these studies we believe might help improve per-cutaneous vaccination against this disease using defined candidate vaccine antigens against schistosomiasis. ..
  50. Role of SOCS proteins in host-pathogen responses
    Peter Murray; Fiscal Year: 2003
    ..PERFORMANCE SITE (S) (organization, city, state) St. Jude Children's Research Hospital, Memphis, TN . ..
  51. MULTIVALENT VACCINE FOR LYMPHATIC FILARIASIS
    Ramaswamy Kalyanasundaram; Fiscal Year: 2010
    ..The proposed studies are based on solid preliminary data and are hypotheses driven. Results from these studies, we believe will advance our knowledge towards developing a defined vaccine against lymphatic filariasis in the human. ..