Igf2r

Summary

Gene Symbol: Igf2r
Description: insulin-like growth factor 2 receptor
Alias: AI661837, CD222, CI-MPR, M6P/IGF2R, Mpr300, cation-independent mannose-6-phosphate receptor, 300 kDa mannose 6-phosphate receptor, CI Man-6-P receptor, IGF-II receptor, IGF-II/CI-MPR, M6P/IGF2 receptor, M6PR, MPR 300, cation-independent MPR, insulin-like growth factor II receptor, mannose-6-phosphate receptor, cation independent
Species: mouse

Top Publications

  1. pmc The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis
    Michael W McBurney
    Ottawa Regional Cancer Centre and Department of Medicine, University of Ottawa, Ontario K1H 1C4, Canada
    Mol Cell Biol 23:38-54. 2003
  2. ncbi Regulation of embryonic growth and lysosomal targeting by the imprinted Igf2/Mpr gene
    Z Q Wang
    Research Institute for Molecular Pathology I M P, Vienna, Austria
    Nature 372:464-7. 1994
  3. ncbi Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality
    M M Lau
    Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110
    Genes Dev 8:2953-63. 1994
  4. ncbi Imprinted expression of the Igf2r gene depends on an intronic CpG island
    A Wutz
    Institute of Molecular Pathology, Vienna, Austria
    Nature 389:745-9. 1997
  5. ncbi Local reduction of organ size in transgenic mice expressing a soluble insulin-like growth factor II/mannose-6-phosphate receptor
    S Zaina
    Department of Zoology, University of Oxford, United Kingdom
    Endocrinology 139:3886-95. 1998
  6. ncbi Non-imprinted Igf2r expression decreases growth and rescues the Tme mutation in mice
    A Wutz
    Research Institute for Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Development 128:1881-7. 2001
  7. pmc Tissue-specific inactivation of murine M6P/IGF2R
    Andrew A Wylie
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Pathol 162:321-8. 2003
  8. ncbi Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting
    Masahiro Kaneda
    Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Research Organization of Information and Systems, Mishima 411 8540, Japan
    Nature 429:900-3. 2004
  9. ncbi Demonstration of tumor suppression by mannose 6-phosphate/insulin-like growth factor 2 receptor
    Jin Li
    Department of Physiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Oncogene 23:9359-68. 2004
  10. ncbi Altered levels and distribution of IGF-II/M6P receptor and lysosomal enzymes in mutant APP and APP + PS1 transgenic mouse brains
    A Amritraj
    Department of Psychiatry, University of Alberta, Edmonton, Canada
    Neurobiol Aging 30:54-70. 2009

Research Grants

  1. Mechanisms for immune tolerance in Pompe Disease
    Dwight D Koeberl; Fiscal Year: 2010
  2. Gene delivery to striated muscle by systemic AAV vectors
    Dwight D Koeberl; Fiscal Year: 2010
  3. Pathogenesis of autoimmune myositis: Role of MHC Class 1
    Kanneboyina Nagaraju; Fiscal Year: 2009

Scientific Experts

  • Dwight Koeberl
  • Ralf Dressel
  • R Shemer
  • Hyeon Sook Suh
  • Takashi Nagano
  • Kanneboyina Nagaraju
  • Yasutomi Kamei
  • Nasser Al Shanti
  • P M Coan
  • C M Nolan
  • E F Wagner
  • S Zaina
  • T Braulke
  • Rahimah Zakaria
  • M P Hoffman
  • R H McCusker
  • M N J Seaman
  • TINA F JASKOLL
  • Michael W McBurney
  • Vladimir Leksa
  • Paulina A Latos
  • Katarzyna E Warczok
  • Denise P Barlow
  • Florian M Pauler
  • D P Barlow
  • Quanah J Hudson
  • A Wutz
  • Stefan H Stricker
  • Hannes Stockinger
  • Yosuke Hiramuki
  • Kazuya Fujita
  • In Seon Choi
  • M Azim Surani
  • John P Hagan
  • Xing Wei Liang
  • Takayuki Okano
  • Tatiana Novitskaya
  • Martha V Koerner
  • Linda J Olson
  • Anthony P Popkie
  • Ru Huang
  • Daniele Belluoccio
  • Kenichiro Hata
  • Diana Klein
  • A Amritraj
  • Maria I Mascarenhas
  • Anne Gabory
  • Olivia C Probst
  • Robert J Wood
  • Dimitrina D Pravtcheva
  • Nasser Al-Shanti
  • Kouji Nagata
  • Peng Wei
  • Sherry Wanderling
  • Bernd R Binder
  • Johannes Breuss
  • N Schweifer
  • M Fukasawa
  • K Regha
  • Yoko Yamasaki
  • Tao Fan
  • Sylvie Croteau
  • Courtney T Griffin
  • Javier Caton
  • Serguei V Kozlov
  • Colin L Stewart
  • Terry Magnuson
  • Jesika S Faridi
  • Jin Li
  • Masahiro Kaneda
  • Jesse Mager
  • Jacques P M Schellens
  • En Li
  • Tomas Vacik
  • Masaki Okano
  • Andrew A Wylie
  • Takahiko Sato
  • Atsuko Sehara-Fujisawa
  • Yasuhide Furuta
  • W Lerchner
  • Bonnie Reinhart
  • PIROSKA E SZABO
  • Peter W Laird
  • Shirley Oghamian
  • Takaaki Aoba
  • Yoshihito Shimazu
  • Yuuichi Soeno
  • Hee Ju Kim
  • Cindy Carroll
  • M A Surani

Detail Information

Publications103 found, 100 shown here

  1. pmc The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis
    Michael W McBurney
    Ottawa Regional Cancer Centre and Department of Medicine, University of Ottawa, Ontario K1H 1C4, Canada
    Mol Cell Biol 23:38-54. 2003
    ..The phenotype of the sir2alpha null animals suggests that the SIR2alpha protein is essential for normal embryogenesis and for normal reproduction in both sexes...
  2. ncbi Regulation of embryonic growth and lysosomal targeting by the imprinted Igf2/Mpr gene
    Z Q Wang
    Research Institute for Molecular Pathology I M P, Vienna, Austria
    Nature 372:464-7. 1994
    ..A few (-/+) mice reactivated their paternal Igf2/Mpr allele in some tissues and survived to adults. But no (-/-) mice survived, indicating a role for the reactivated paternal allele in postnatal survival...
  3. ncbi Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality
    M M Lau
    Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110
    Genes Dev 8:2953-63. 1994
    ..that inherit a nonfunctional insulin-like growth factor-II/cation-independent mannose 6-phosphate receptor (Igf2r) gene from their fathers are viable and develop normally into adults...
  4. ncbi Imprinted expression of the Igf2r gene depends on an intronic CpG island
    A Wutz
    Institute of Molecular Pathology, Vienna, Austria
    Nature 389:745-9. 1997
    ..The mouse Igf2r gene (encoding the receptor for insulin- like growth factor type-2) is imprinted and is expressed from the ..
  5. ncbi Local reduction of organ size in transgenic mice expressing a soluble insulin-like growth factor II/mannose-6-phosphate receptor
    S Zaina
    Department of Zoology, University of Oxford, United Kingdom
    Endocrinology 139:3886-95. 1998
    Genetic evidence suggests that the insulin-like growth factor II (IGF-II)/mannose-6-phosphate receptor (IGF2R) slows growth...
  6. ncbi Non-imprinted Igf2r expression decreases growth and rescues the Tme mutation in mice
    A Wutz
    Research Institute for Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Development 128:1881-7. 2001
    In the mouse the insulin-like growth factor receptor type 2 gene (Igf2r) is imprinted and maternally expressed...
  7. pmc Tissue-specific inactivation of murine M6P/IGF2R
    Andrew A Wylie
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Pathol 162:321-8. 2003
    The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) encodes a multifunctional protein involved in lysosomal enzyme trafficking, fetal organogenesis, tumor suppression, and T cell- mediated immunity...
  8. ncbi Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting
    Masahiro Kaneda
    Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Research Organization of Information and Systems, Mishima 411 8540, Japan
    Nature 429:900-3. 2004
    ..These results indicate that both Dnmt3a and Dnmt3L are required for methylation of most imprinted loci in germ cells, but also suggest the involvement of other factors...
  9. ncbi Demonstration of tumor suppression by mannose 6-phosphate/insulin-like growth factor 2 receptor
    Jin Li
    Department of Physiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    Oncogene 23:9359-68. 2004
    ..These findings establish a role for the receptor as a bona fide tumor suppressor gene and together with previous studies, suggest an important role for the receptor in human and rodent cancers...
  10. ncbi Altered levels and distribution of IGF-II/M6P receptor and lysosomal enzymes in mutant APP and APP + PS1 transgenic mouse brains
    A Amritraj
    Department of Psychiatry, University of Alberta, Edmonton, Canada
    Neurobiol Aging 30:54-70. 2009
    ....
  11. ncbi Cell surface-expressed cation-independent mannose 6-phosphate receptor (CD222) binds enzymatically active heparanase independently of mannose 6-phosphate to promote extracellular matrix degradation
    Robert J Wood
    Cancer and Molecular Immunology Group, Division of Molecular Bioscience, The John Curtin School of Medical Research, The Australian National University, Acton, Australian Capital Territory 2601, Australia
    J Biol Chem 283:4165-76. 2008
    ....
  12. doi Igf2r improves the survival and transmission ratio of Igf2 transgenic mice
    Dimitrina D Pravtcheva
    Department of Human Genetics, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    Mol Reprod Dev 75:1678-87. 2008
    ..Degradation of IGFII is mediated by the insulin-like growth factor type 2 receptor (IGF2R)...
  13. pmc An in vitro ES cell imprinting model shows that imprinted expression of the Igf2r gene arises from an allele-specific expression bias
    Paulina A Latos
    CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Dr Bohr Gasse 9 4, Vienna Biocenter, A 1030 Vienna, Austria
    Development 136:437-48. 2009
    ..The mouse Igf2r gene shows imprinted expression only in post-implantation stages, when repression of the paternal allele has been ..
  14. doi The mannose 6-phosphate/insulin-like growth factor II receptor restricts the tumourigenicity and invasiveness of squamous cell carcinoma cells
    Olivia C Probst
    Institute of Applied Genetics and Cell Biology, University of Natural Resources and Applied Life Sciences, Vienna, Austria
    Int J Cancer 124:2559-67. 2009
    The mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) mediates biosynthetic sorting and endocytosis of various factors that impinge on the proliferation, migration and invasiveness of tumour cells...
  15. ncbi Intraspecific mating with CzechII/Ei mice rescue lethality associated with loss of function mutations of the imprinted genes, Igf2r and Cdkn1c
    John P Hagan
    Cancer and Developmental Biology Laboratory, Center for Cancer Research, NCI FCRDC, National Institutes of Health, P O Box B, Frederick, MD 21702, USA
    Genomics 84:836-43. 2004
    ..encoding either the cyclin-dependent kinase inhibitor 1C (Cdkn1c) or the insulin-like growth factor 2 receptor (Igf2r) leads to fully penetrant perinatal lethality in C57BL/6J mice due to genomic imprinting...
  16. ncbi Expression of genes for insulin and insulin-like growth factors and receptors in early postimplantation mouse embryos and embryonal carcinoma cells
    N A Telford
    Department of Medical Biochemistry, University of Calgary Health Sciences Centre, Alberta, Canada
    Mol Reprod Dev 27:81-92. 1990
    ..g., maternal) sources of insulin. Both IGF-I and IGF-II could act as paracrine or autocrine growth factors, and IGF-II is the more abundant growth factor in differentiating F9 cells...
  17. ncbi Structure of the receptor for insulin-like growth factor II: the puzzle amplified
    R A Roth
    Department of Pharmacology, Stanford University School of Medicine, CA 94305 5332
    Science 239:1269-71. 1988
    ..Since this latter receptor has been implicated in targeting of lysosomal enzymes, the question is now raised of whether the same protein can also mediate metabolic responses to IGF-II...
  18. ncbi The non-viability of uniparental mouse conceptuses correlates with the loss of the products of imprinted genes
    C Walsh
    Institute for Experimental Drug Research, Karolinska Hospital, Stockholm, Sweden
    Mech Dev 46:55-62. 1994
    ..four such endogenous imprinted genes are known: the paternal alleles of Igf2 and Snrpn and the maternal alleles of Igf2r and H19 are active, while their opposite parental alleles are inactive...
  19. ncbi Expression of mannose 6-phosphate receptors in chicken
    U Matzner
    Zentrum Biochemie und Molekulare Zellbiologie, Georg August Universitat Gottingen, Germany
    Dev Dyn 207:11-24. 1996
    ..synthesized lysosomal enzymes is accomplished by two mannose 6-phosphate receptors (MPR) designated MPR46 and MPR300. MPR300 has an additional function in clearing the nonglycosylated insulin-like growth factor II (IGFII)...
  20. ncbi Insulin-like growth factor-2 regulation of conceptus composition: effects of the trophectoderm and inner cell mass genotypes in the mouse
    R L Gardner
    Zoology Department, Oxford University, Oxford OX1 3PS, United Kingdom
    Biol Reprod 60:190-5. 1999
    ....
  21. ncbi Variable accumulation of insulin-like growth factor II in mouse tissues deficient in insulin-like growth factor II receptor
    C M Nolan
    Zoology Department, University College Dublin, Belfield, Ireland
    Int J Biochem Cell Biol 31:1421-33. 1999
    ..These results indicate that lack of insulin-like growth factor II receptor can lead to local excess of the growth factor but that such excess is not a necessary consequence of receptor-deficiency...
  22. ncbi Targeted disruption of the cation-dependent or cation-independent mannose 6-phosphate receptor does not decrease the content of acid glycosidases in the acrosome
    C A Chayko
    Center for Reproductive Biology Research, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2633, USA
    J Androl 21:944-53. 2000
    ..These results suggest that the targeted disruption of either MPR does not result in decreased acrosomal targeting efficiency...
  23. ncbi Quantification of expression and methylation of the Igf2r imprinted gene in segmental trisomic mouse model
    Tomas Vacik
    Institute of Molecular Genetics and Center of Integrated Genomics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 4, Prague, Czech Republic
    Genomics 82:261-8. 2003
    Insulin-like growth factor 2 receptor (Igf2r), a maternally expressed imprinted gene, is triplicated in Ts43H trisomic mice...
  24. pmc GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion
    Sherry Wanderling
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Mol Biol Cell 18:3764-75. 2007
    ..The data identify insulin-like growth factor II as one developmentally important protein whose production depends on the activity of GRP94...
  25. doi Insulin-like growth factor signaling regulates the timing of sensory cell differentiation in the mouse cochlea
    Takayuki Okano
    Laboratory of Cochlear Development, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Porter Neuroscience Research Center, Bethesda, Maryland 20892, USA
    J Neurosci 31:18104-18. 2011
    ..The results also provide new insights regarding the pathological processes that underlie auditory defects in the absence of IGF signaling in both humans and mice...
  26. ncbi Rescue of the T-associated maternal effect in mice carrying null mutations in Igf-2 and Igf2r, two reciprocally imprinted genes
    A J Filson
    Department of Genetics and Development, Columbia University, New York, NY 10032
    Development 118:731-6. 1993
    ..Interestingly, the Igf2r gene, which encodes one of the two known receptors (IGF2R) to which IGF-II binds with high affinity is also ..
  27. ncbi Genomic imprinting. Silence of the genes
    M A Surani
    Nature 366:302-3. 1993
  28. ncbi Growth-promoting interaction of IGF-II with the insulin receptor during mouse embryonic development
    A Louvi
    Department of Genetics and Development, Columbia University, New York, New York, 10032, USA
    Dev Biol 189:33-48. 1997
    ..Therefore, these results provide genetic evidence that the growth-promoting function of IGF-II during mouse embryogenesis is mediated in part by signaling through the insulin receptor...
  29. ncbi Mutational analysis of the binding site residues of the bovine cation-dependent mannose 6-phosphate receptor
    L J Olson
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 274:36905-11. 1999
    ..In addition, mutation of the single histidine residue, His-105, within the binding site diminished the binding of the receptor to ligand, but did not eliminate the ability of the CD-MPR to release ligand under acidic conditions...
  30. ncbi The imprinted antisense RNA at the Igf2r locus overlaps but does not imprint Mas1
    R Lyle
    The Netherlands Cancer Institute H5, Amsterdam, The Netherlands
    Nat Genet 25:19-21. 2000
    The gene encoding the insulin-like growth-factor type-2 receptor (Igf2r) is maternally expressed and imprinted...
  31. pmc Shared role for differentially methylated domains of imprinted genes
    Bonnie Reinhart
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Mol Cell Biol 22:2089-98. 2002
    ..To examine this possibility, we introduced sequences from the DMDs of the imprinted Igf2r, H19, and Snrpn genes into a nonimprinted derivative of the normally imprinted RSVIgmyc transgene, created by ..
  32. ncbi Unimpaired allorejection of cells deficient for the mannose 6-phosphate receptors Mpr300 and Mpr46
    Ralf Dressel
    Division of Immunogenetics, University of Gottingen, Heirich Duker Weg 12, 37073 Gottingen, Germany
    Transplantation 78:758-61. 2004
    ..Using mouse embryonal fibroblasts from Mpr300 and Mpr46 knockout mice, we show that both Mpr 300 and Mpr46 are dispensable on target cells for lysis and apoptosis mediated by alloreactive CTL in vitro and for ..
  33. ncbi Neuron-specific relaxation of Igf2r imprinting is associated with neuron-specific histone modifications and lack of its antisense transcript Air
    Yoko Yamasaki
    Department of Human Genetics, Graduate School of Biomedical Sciences, Nagasaki 852 8523, Japan
    Hum Mol Genet 14:2511-20. 2005
    The mouse insulin-like growth factor II receptor (Igf2r) gene and its antisense transcript Air are reciprocally imprinted in most tissues, but in the brain, Igf2r is biallelically expressed despite the imprinted Air expression...
  34. ncbi Peg1/Mest in obese adipose tissue is expressed from the paternal allele in an isoform-specific manner
    Yasutomi Kamei
    Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kanda surugadai, Tokyo, Japan
    FEBS Lett 581:91-6. 2007
    ..We also demonstrated that the abundantly expressed Peg1/Mest in obese adipose tissue retained monoallelic expression. This is the first report of monoallelic induction of Peg1/Mest in adult tissues...
  35. doi Beneficial synergistic interactions of TNF-alpha and IL-6 in C2 skeletal myoblasts--potential cross-talk with IGF system
    Nasser Al-Shanti
    Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, Cheshire, England, UK
    Growth Factors 26:61-73. 2008
    ..Our data suggest that in the presence of TNF-alpha/IL-6 functions positively and potentially also cooperatively with the IGF system to achieve the maximal beneficial effect on skeletal myoblast numbers...
  36. doi Mannose 6-phosphate receptor-dependent endocytosis of lysosomal enzymes is increased in sulfatide-storing kidney cells
    Diana Klein
    Institut fur Physiologische Chemie, Rheinische Friedrich Wilhelms Universitat, Nussallee 11, D 53115 Bonn, Germany
    Biol Chem 390:41-8. 2009
    ..Examination of mannose 6-phosphate receptor (MPR300)-dependent endocytosis revealed that uptake of lysosomal enzymes is more than two-fold increased in sulfatide-..
  37. pmc Structural basis for recognition of phosphodiester-containing lysosomal enzymes by the cation-independent mannose 6-phosphate receptor
    Linda J Olson
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Proc Natl Acad Sci U S A 107:12493-8. 2010
    ..These results show the mechanism by which the CI-MPR recognizes Man-P-GlcNAc-containing ligands and provides new avenues to investigate the role of phosphodiester-containing lysosomal enzymes in the biogenesis of lysosomes...
  38. pmc Enhanced efficacy of enzyme replacement therapy in Pompe disease through mannose-6-phosphate receptor expression in skeletal muscle
    Dwight D Koeberl
    Division of Medical Genetics, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Mol Genet Metab 103:107-12. 2011
    ..In summary, enhanced CI-MPR expression might improve the efficacy of enzyme replacement therapy in Pompe disease through enhancing receptor-mediated uptake of GAA...
  39. doi The effects of postovulatory aging of mouse oocytes on methylation and expression of imprinted genes at mid-term gestation
    Xing Wei Liang
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, People s Republic of China
    Mol Hum Reprod 17:562-7. 2011
    ..Methylation and total expression of Igf2r and H19 was investigated by quantitative analysis of methylation by PCR and quantitative real-time RT-PCR, ..
  40. pmc Mest but Not MiR-335 Affects Skeletal Muscle Growth and Regeneration
    Yosuke Hiramuki
    Department of Growth Regulation, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    PLoS ONE 10:e0130436. 2015
    ..Moreover, expressions of H19 and Igf2r, maternally expressed imprinted genes were affected in tibialis anterior muscle of Mest+/-; DMD-null mice compared ..
  41. doi Airn transcriptional overlap, but not its lncRNA products, induces imprinted Igf2r silencing
    Paulina A Latos
    CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, 1090 Vienna, Austria
    Science 338:1469-72. 2012
    ..To test whether Airn transcription or product silences the Igf2r gene, we shortened the endogenous lncRNA to different lengths...
  42. doi Sorting of growth plate chondrocytes allows the isolation and characterization of cells of a defined differentiation status
    Daniele Belluoccio
    Murdoch Children s Research Institute, University of Melbourne, Royal Children s Hospital, Parkville, Victoria, Australia
    J Bone Miner Res 25:1267-81. 2010
    ..This approach provides a novel platform to study cartilage development and characterize mouse growth plate chondrocytes to reveal unique cellular phenotypes of the distinct subpopulations within the growth plate...
  43. doi Molecular signaling at the fusion stage of the mouse mandibular arch: involvement of insulin-like growth factor family
    Kazuya Fujita
    Department of Pathology, School of Life Dentistry at Tokyo, The Nippon Dental University, Tokyo, Japan
    Int J Dev Biol 57:399-406. 2013
    ....
  44. pmc Alterations in deoxyribonucleic acid (DNA) methylation patterns of Calca, Timp3, Mmp2, and Igf2r are associated with chronic cystitis in a cyclophosphamide-induced mouse model
    In Seon Choi
    Division of Pediatric Urology, Saban Research Institute, Children s Hospital Los Angeles, Los Angeles, CA, USA
    Urology 82:253.e9-15. 2013
    ..To determine whether epigenetic changes occur during cyclophosphamide-induced chronic bladder inflammation in mice...
  45. ncbi Expression of the two mannose 6-phosphate receptors is spatially and temporally different during mouse embryogenesis
    U Matzner
    Universitat Gottingen, FRG
    Development 114:965-72. 1992
    Mammalian cells express two mannose 6-phosphate receptors, MPR46 and MPR300, both of which mediate the targeting of lysosomal enzymes to lysosomes...
  46. ncbi Differential regulation of mannose 6-phosphate receptors and their ligands during the myogenic development of C2 cells
    G Szebenyi
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    J Biol Chem 266:5534-9. 1991
    ..The differential regulation of the two mannose 6-phosphate receptors during muscle differentiation suggests that they may serve distinct functions in development...
  47. ncbi Chromosomal mapping of the gene for the type II insulin-like growth factor receptor/cation-independent mannose 6-phosphate receptor in man and mouse
    G Laureys
    Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06510
    Genomics 3:224-9. 1988
    The gene for insulin-like growth factor II (IGF-II) receptor (IGF2R) that has recently been found, by DNA sequencing, to be identical to the cation-independent mannose 6-phosphate receptor (CIM6PR) has been mapped in the human and murine ..
  48. ncbi Proliferin secreted by cultured cells binds to mannose 6-phosphate receptors
    S J Lee
    Howard Hughes Medical Institute Laboratory, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
    J Biol Chem 263:3521-7. 1988
    ....
  49. ncbi Developmental regulation of genomic imprinting during gametogenesis
    A J Villar
    Department of Anatomy, University of California, San Francisco 94143, USA
    Dev Biol 172:264-71. 1995
    ....
  50. ncbi The IGFs and their binding proteins in murine development
    L J Murphy
    Department of Internal Medicine, University of Manitoba, Winnipeg, Canada
    Mol Reprod Dev 35:376-81. 1993
    ..We have started to develop transgenic mice lines overexpressing IGFBPs to attempt to address the role of these binding proteins in fetal development...
  51. ncbi Cellular patterns of insulin-like growth factor system gene expression in murine chondrogenesis and osteogenesis
    E Wang
    Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 136:2741-51. 1995
    ....
  52. ncbi Allele-specific structures in the mouse Igf2-H19 domain
    M Ariel
    Department of Cellular Biochemistry, Hebrew University Medical School, Jerusalem, Israel
    Cold Spring Harb Symp Quant Biol 58:307-13. 1993
  53. ncbi Expression and methylation of imprinted genes during in vitro differentiation of mouse parthenogenetic and androgenetic embryonic stem cell lines
    P Szabo
    Division of Biology, Beckman Research Institute of the City of Hope, Duarte, California 91010 0269
    Development 120:1651-60. 1994
    Messenger RNA and methylation levels of four imprinted genes, H19, Igf2r, Igf-2 and Snrpn were examined by northern and Southern blotting in mouse parthenogenetic, androgenetic and normal or wild-type embryonic stem cell lines during ..
  54. ncbi Fetal weight at term influenced by H-2-associated loci
    M L Tyan
    Veterans Affairs Medical Center, West Los Angeles, California 90073
    Proc Soc Exp Biol Med 205:85-8. 1994
    ..A x B10.BR and B10.A x B10.D2 but not the B10.A x C57BL/10 crosses. The results suggest that there are two or more MHC associated loci that influence growth rate in late gestation. Among the candidate genes are Ped and Igfr II...
  55. ncbi The mouse insulin-like growth factor II/cation-independent mannose 6-phosphate (IGF-II/MPR) receptor gene: molecular cloning and genomic organization
    G Szebenyi
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    Genomics 19:120-9. 1994
    ..abstract truncated at 250 words)..
  56. ncbi Cloning and sequencing of cDNAs encoding the full-length mouse mannose 6-phosphate/insulin-like growth factor II receptor
    T Ludwig
    European Molecular Biology Laboratory, Cell Biology Programme, Heidelberg, Germany
    Gene 142:311-2. 1994
    ..The open reading frame encodes a protein of 2482 amino acids that is 89 and 87% identical to the human and bovine receptors, respectively...
  57. ncbi The insulin-like growth factor type-2 receptor gene is imprinted in the mouse but not in humans
    V M Kalscheuer
    Department of Human Genetics, University Hospital Nijmegen, The Netherlands
    Nat Genet 5:74-8. 1993
    ..IGF2 is monoallelically expressed in various tissues but surprisingly not in adult human liver. The human IGF2R gene, another classic example of imprinting in mice, was found to be expressed from both alleles...
  58. ncbi Allele-specific replication timing of imprinted gene regions
    D Kitsberg
    Department of Cellular Biochemistry, Hebrew University Medical School, Jerusalem, Israel
    Nature 364:459-63. 1993
    ..we have examined the replication timing patterns for the chromosomal regions containing the imprinted genes Igf2, Igf2r, H19 and Snrpn in the mouse...
  59. ncbi Expression of IGF ligand and receptor genes during preimplantation mammalian development
    G A Schultz
    Department of Medical Biochemistry, University of Calgary, Alberta, Canada
    Mol Reprod Dev 35:414-20. 1993
    ..These findings suggest that the interactions of IGF ligands and receptors in preimplantation development might, indeed, be modulated by IGFPs.(ABSTRACT TRUNCATED AT 250 WORDS)..
  60. ncbi Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal
    R Stöger
    Research Institute of Molecular Pathology, Vienna, Austria
    Cell 73:61-71. 1993
    The mouse insulin-like growth factor type 2 receptor (Igf2r) is imprinted and expressed exclusively from the maternally inherited chromosome...
  61. ncbi Allele-specific expression and total expression levels of imprinted genes during early mouse development: implications for imprinting mechanisms
    P E Szabo
    Division of Biology, Beckman Research Institute of the City Hope, Duarte, California 91010, USA
    Genes Dev 9:3097-108. 1995
    ..The Igf2r and Snrpn genes were activated by the early 4-cell stage and exhibited biallelic and monoallelic expression, ..
  62. ncbi Mouse embryos with paternal duplication of an imprinted chromosome 7 region die at midgestation and lack placental spongiotrophoblast
    K J Mclaughlin
    Division of Biology, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA
    Development 122:265-70. 1996
    ..d7 phenotype is p-/p- expression of this gene. We also confirm that PatDup.d7 embryos lack H19 RNA and posses excess Igf2 RNA as might be expected from the parental-specific activities of these genes in normal embryos...
  63. pmc Neither type of mannose 6-phosphate receptor is sufficient for targeting of lysosomal enzymes along intracellular routes
    D Kasper
    Georg August University, Abt Biochemie II, Gottingen, Germany
    J Cell Biol 134:615-23. 1996
    Mouse embryonic fibroblasts that are deficient in the two mannose 6-phosphate receptors (MPRs) MPR 46 and MPR 300 missort the majority (> or = 85%) of soluble lysosomal proteins into the medium...
  64. ncbi The Lx1 gene maps to mouse chromosome 17 and codes for a protein that is homologous to glucose and polyspecific transmembrane transporters
    N Schweifer
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Mamm Genome 7:735-40. 1996
    ..The Lx1 gene maps very close to the imprinted Igf2r/Mpr300 gene on mouse Chromosome (Chr) 17, in a region that is syntenic to human Chr 6q...
  65. pmc Maternal and paternal genomes function independently in mouse ova in establishing expression of the imprinted genes Snrpn and Igf2r: no evidence for allelic trans-sensing and counting mechanisms
    P E Szabo
    Division of Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010 3000, USA
    EMBO J 15:6018-25. 1996
    ..allele-specific RT-PCR single nucleotide primer extension assays developed for two imprinted genes, Snrpn and Igf2r, we demonstrate: (i) No role for maternal-paternal allelic interactions: the modes of parental-specific expression ..
  66. ncbi Paternal repression of the imprinted mouse Igf2r locus occurs during implantation and is stable in all tissues of the post-implantation mouse embryo
    W Lerchner
    Netherlands Cancer Institute, Amsterdam, The Netherlands
    Mech Dev 61:141-9. 1997
    The insulin-like growth factor type 2 receptor, also known as the cation independent mannose-6-phosphate receptor (Igf2r) is an imprinted gene, which is repressed on the paternally inherited allele in midgestation mouse embryos...
  67. ncbi Characterization of the C3 YAC contig from proximal mouse chromosome 17 and analysis of allelic expression of genes flanking the imprinted Igf2r gene
    N Schweifer
    The Netherlands Cancer Institute H5, Amsterdam
    Genomics 43:285-97. 1997
    The imprinted mouse insulin-like growth factor type 2 receptor (Igf2r) maps to the middle of a gene-rich region in band A2 of mouse chromosome 17...
  68. pmc Structure of the imprinted mouse Snrpn gene and establishment of its parental-specific methylation pattern
    R Shemer
    Department of Cellular Biochemistry, Hebrew University Hadassah Medical School, P O Box 12272, Jerusalem, 91120, Israel
    Proc Natl Acad Sci U S A 94:10267-72. 1997
    ..That all PWS patients lack DMR1, together with the overall high resemblance of the mouse gene to the human SNRPN, offers an excellent experimental tool to study the regional control of this imprinted chromosomal domain...
  69. ncbi Insulin-like growth factor II receptor, transforming growth factor-beta, and Cdk4 expression and the developmental epigenetics of mouse palate morphogenesis and dysmorphogenesis
    M Melnick
    Laboratory for Developmental Genetics, University of Southern California, Los Angeles 90089 0641, USA
    Dev Dyn 211:11-25. 1998
    ..Specifically, we evaluated the relationship between Igf2r gene expression, transforming growth factor-beta (TGF-beta) activation, and cdk4 gene expression...
  70. ncbi Altered imprinted gene methylation and expression in completely ES cell-derived mouse fetuses: association with aberrant phenotypes
    W Dean
    Laboratory of Developmental Genetics Programme, The Babraham Institute, Babraham Hall, Cambridge CB2 4AT, UK
    Development 125:2273-82. 1998
    ..this is associated with epigenetic alterations in imprinted genes, we analysed two maternally expressed genes (Igf2r, H19) and two paternally expressed genes (Igf2, U2af1-rs1) in ES cells and in completely ES cell-derived fetuses...
  71. ncbi The sins of the fathers and mothers: genomic imprinting in mammalian development
    S M Tilghman
    Howard Hughes Medical Institute and Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Cell 96:185-93. 1999
  72. ncbi Developmental potential of mouse primordial germ cells
    Y Kato
    Wellcome CRC Institute of Cancer and Developmental Biology and Physiological Laboratory, Tennis Court Road, University of Cambridge, Cambridge CB2 1QR, UK
    Development 126:1823-32. 1999
    ..The evidence suggests that gametic imprints are essential for normal development, and that they can neither be initiated nor erased in mature oocytes; these properties are unique to the developing germ line...
  73. ncbi Type-2 IGF receptor: a multi-ligand binding protein
    T Braulke
    Institute for Biochemistry II, Georg August Universitat Gottingen, Germany
    Horm Metab Res 31:242-6. 1999
    The Type-2 insulin-like growth factor receptor (IGF2R) is a ubiquitously expressed integral glycoprotein with a molecular mass of 300 kDa...
  74. ncbi I-cell disease-like phenotype in mice deficient in mannose 6-phosphate receptors
    F Dittmer
    Georg August Universitat Gottingen, Abt Biochemie II, Germany
    Transgenic Res 7:473-83. 1998
    ..by crossing mice carrying null alleles for Igf2 and the 300 kDa and 46 kDa mannose 6-phosphate receptors, Mpr300 and Mpr46. Pre- and perinatal lethality of mice nullizygous for Igf2, Mpr300 and Mpr46 was increased...
  75. ncbi Submandibular gland morphogenesis: stage-specific expression of TGF-alpha/EGF, IGF, TGF-beta, TNF, and IL-6 signal transduction in normal embryonic mice and the phenotypic effects of TGF-beta2, TGF-beta3, and EGF-r null mutations
    T Jaskoll
    Laboratory for Developmental Genetics, University of Southern California, Los Angeles, California, 90089, USA
    Anat Rec 256:252-68. 1999
    ..These and other findings provide insight into the design of future functional studies...
  76. ncbi Differential chromatin packaging of genomic imprinted regions between expressed and non-expressed alleles
    T Watanabe
    First Department of Biochemistry, Niigata University School of Medicine, Asahimachi 1 757, Niigata 951 8122, Japan
    Hum Mol Genet 9:3029-35. 2000
    ..examined the chromatin packaging state of allelic sites in the Zfp127/Snrpn locus on mouse chromosome 7 and in the Igf2r locus on mouse chromosome 17 with an assay consisting of chromatin fractionation and allele-specific detection...
  77. pmc Bidirectional action of the Igf2r imprint control element on upstream and downstream imprinted genes
    R Zwart
    Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Genes Dev 15:2361-6. 2001
    Imprinting of the maternally-expressed Igf2r gene is controlled by an intronic imprint control element (ICE) known as Region2 that contains the promoter of the noncoding Air RNA, whose transcript overlaps the silenced paternal Igf2r ..
  78. ncbi Allele-specific expression of imprinted genes in mouse migratory primordial germ cells
    PIROSKA E SZABO
    Division of Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010 3011, USA
    Mech Dev 115:157-60. 2002
    ..by flow cytometry and determined the allele-specific expression of four imprinted genes - Snrpn, Igf2, H19 and Igf2r. The first three genes were expressed monoallelically, while the latter gene was expressed biallelically...
  79. ncbi Genome imprinting regulated by the mouse Polycomb group protein Eed
    Jesse Mager
    Department of Genetics and Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, 103 Mason Farm Road, Chapel Hill, North Carolina 27599 7264, USA
    Nat Genet 33:502-7. 2003
    ..These data identify Eed as a member of a new class of trans-acting factors that regulate parent-of-origin expression at imprinted loci...
  80. ncbi Deficiency of mannose 6-phosphate receptors and lysosomal storage: a morphometric analysis of hepatocytes of neonatal mice
    Jacques P M Schellens
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, P O Box 22700, 1100 DE, Amsterdam, The Netherlands
    Cell Biol Int 27:897-902. 2003
    ..It is concluded that in hepatocytes of MPR-deficient neonatal mice lysosomal storage occurs when both MPRs are lacking, whereas deficiency of CI-MPR only has no effect on the ultrastructure of the lysosomal system...
  81. pmc Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer
    Matthew N J Seaman
    Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Addenbrookes Hospital, Hills Road, Cambridge CB2 2XY, England, UK
    J Cell Biol 165:111-22. 2004
    ..The data presented here support the hypothesis that retromer performs a selective function in endosome-to-Golgi transport, mediating retrieval of the CI-MPR, but not furin...
  82. ncbi Modulation of cathepsin D routing by IGF-II involves IGF-II binding to IGF-II/M6P receptor in MCF-7 breast cancer cells
    Jesika S Faridi
    Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    Growth Factors 22:169-77. 2004
    ..These data provide direct evidence that the IGF-II modulation of cathepsin D routing is IGF-II/M6P receptor mediated...
  83. ncbi Lsh controls silencing of the imprinted Cdkn1c gene
    Tao Fan
    Laboratory of Molecular Immunoregulation, Basic Research Program, SAIC Frederick, National Cancer Institute, Frederick, MD 21702 1201, USA
    Development 132:635-44. 2005
    ..of the Cdkn1c gene (also known as p57(Kip2)) but does not interfere with maintenance of imprints at the H19, Igf2, Igf2r, Zac1 and Meg9 genes...
  84. ncbi IGFs increase enamel formation by inducing expression of enamel mineralizing specific genes
    Javier Caton
    Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, 2250 Alcazar St, CSA 106, Los Angeles, CA 90033, USA
    Arch Oral Biol 50:123-9. 2005
    ..These results suggest that IGFs increase enamel formation by the induction of gene expression of enamel related genes. Studies are underway to determine a possible mechanism for these factors...
  85. ncbi Increased plasticity of genomic imprinting of Dlk1 in brain is due to genetic and epigenetic factors
    Sylvie Croteau
    Department of Obstetrics and Gynecology, Royal Victoria Hospital, McGill University Health Centre, Montreal, Quebec, Canada
    Mamm Genome 16:127-35. 2005
    The expression of six imprinted genes (Dlk1, Gt12, Igf2r, Kcnq1, Nnat, and Peg1) was examined in brains of 21 mice derived from N2 x N2 intercrosses between C57BL/6 and MOLF/Ei strains...
  86. pmc Long-range DNase I hypersensitivity mapping reveals the imprinted Igf2r and Air promoters share cis-regulatory elements
    Florian M Pauler
    CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Institute of Genetics, Max F Perutz Laboratories, Vienna Biocenter, A1030 Vienna, Austria
    Genome Res 15:1379-87. 2005
    Epigenetic mechanisms restrict the expression of imprinted genes to one parental allele in diploid cells. At the Igf2r/Air imprinted cluster on mouse chromosome 17, paternal-specific expression of the Air noncoding RNA has been shown to ..
  87. ncbi Genomic imprinting in Dicer1-hypomorphic mice
    M Fukasawa
    Biosignal Genome Resource Center, Department of Molecular and Cellular Biology, Gunma University, Maebashi, Japan
    Cytogenet Genome Res 113:138-43. 2006
    ..We did not observe any abnormality in the allelic expression of imprinted genes in these mice or their offspring, suggesting that reduced expression of Dicer1 did not significantly affect the maintenance and reprogramming of imprinting...
  88. ncbi The imprinted mouse Igf2r/Air cluster--a model maternal imprinting system
    K Regha
    CeMM Research Center for Molecular Medicine, Austrian Academy of Sciences, Vienna, Austria
    Cytogenet Genome Res 113:165-77. 2006
    ..The mouse Igf2r/Air cluster is presented as a model of the maternal imprinting system.
  89. ncbi Effect of insulin-like-growth factor and its receptors regarding lung development in fetal mice
    Kouji Nagata
    Department of Pediatric Surgery, Reproductive and Developmental Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Pediatr Surg Int 23:953-9. 2007
    ..Therefore, the administration of IGFs to the fetal CDH lung may thus be able to effectively improve the symptoms of hypoplastic lung...
  90. ncbi Mapping of Cbln1-like immunoreactivity in adult and developing mouse brain and its localization to the endolysosomal compartment of neurons
    Peng Wei
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale Street, MS 323, Memphis, TN 38105 2794, USA
    Eur J Neurosci 26:2962-78. 2007
    ..As cbln3 is only expressed in post-mitotic, post-migratory granule cells, Cbln1 homomeric complexes in precursors and Cbln1-Cbln3 heteromeric complexes in mature granule cells may have distinct functions and turnover...
  91. pmc Dysferlin deficiency enhances monocyte phagocytosis: a model for the inflammatory onset of limb-girdle muscular dystrophy 2B
    Kanneboyina Nagaraju
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC, USA
    Am J Pathol 172:774-85. 2008
    ..Therefore, we hypothesize that mild myofiber damage in dysferlin-deficient muscle stimulates an inflammatory cascade that may initiate, exacerbate, and possibly perpetuate the underlying myofiber-specific dystrophic process...
  92. doi H19 acts as a trans regulator of the imprinted gene network controlling growth in mice
    Anne Gabory
    Genetics and Development Department, INSERM U567, CNRS UMR 8104, University of Paris Descartes, Institut Cochin, Paris, France
    Development 136:3413-21. 2009
    ..Our results also bring further experimental evidence for the existence of the IGN and open new perspectives in the comprehension of the role of genomic imprinting in embryonic growth and in human imprinting pathologies...
  93. pmc Identification of novel regulators of hematopoietic stem cell development through refinement of stem cell localization and expression profiling
    Maria I Mascarenhas
    Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
    Blood 114:4645-53. 2009
    ....
  94. pmc Insulin-like growth factor 2 receptor is an IFNgamma-inducible microglial protein that facilitates intracellular HIV replication: implications for HIV-induced neurocognitive disorders
    Hyeon Sook Suh
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Am J Pathol 177:2446-58. 2010
    Insulin-like growth factor 2 receptor (IGF2R), also known as cation-independent mannose 6-phosphate (M6P) receptor, is a transmembrane glycoprotein localized in the trans-Golgi region and is involved in targeting both M6P-bearing enzymes ..
  95. pmc Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci
    Anthony P Popkie
    Graduate Program in Molecular, Cellular and Developmental Biology, The Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 285:41337-47. 2010
    ..of the de novo DNA methyltransferase Dnmt3a2, causing misexpression of the imprinted genes Igf2, H19, and Igf2r and hypomethylation of their corresponding imprinted control regions...
  96. doi Soluble M6P/IGF2R released by TACE controls angiogenesis via blocking plasminogen activation
    Vladimir Leksa
    Molecular Immunology Unit, Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Austria
    Circ Res 108:676-85. 2011
    ..We previously identified an important regulator of the uPA system in the mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R).
  97. pmc Extra-embryonic-specific imprinted expression is restricted to defined lineages in the post-implantation embryo
    Quanah J Hudson
    CeMM, Research Center for Molecular Medicine of the Austrian Academy of Science, Lazarettgasse 14, AKH BT 25 3, 1090 Vienna, Austria
    Dev Biol 353:420-31. 2011
    ..These results show that the VYS is an improved model for studying the epigenetic mechanisms regulating extra-embryonic-lineage-specific imprinted expression...
  98. pmc Organ-specific defects in insulin-like growth factor and insulin receptor signaling in late gestational asymmetric intrauterine growth restriction in Cited1 mutant mice
    Tatiana Novitskaya
    Division of Nephrology, Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
    Endocrinology 152:2503-16. 2011
    ..In conclusion, IUGR disrupts normal fetal IGF and insulin production and is associated with organ-specific defects in IGF-IR and IR signaling that may regulate asymmetric IUGR in late gestational placental insufficiency...
  99. ncbi Two dominant host resistance genes to pre-B lymphoma in wild-derived inbred mouse strain MSM/Ms
    A Pataer
    Department of Pathology and Biology of Disease, Graduate School of Medicine, Japan
    Cancer Res 56:3716-20. 1996
    ..0). All 13 pre-B lymphoma-bearing backcross mice were homozygous for SL/Kh-derived alleles at these loci. We named the gene on chromosome 17 Msmr1 (for MSM resistance 1) and that on chromosome 18 Msmr 2 (for MSM resistance 2)...
  100. ncbi The N terminus of mannose 6-phosphate/insulin-like growth factor 2 receptor in regulation of fibrinolysis and cell migration
    Vladimir Leksa
    Institute of Immunology, Vienna International Research Cooperation Center at Novartis Forschungs institut, University of Vienna, Vienna A 1235, Austria
    J Biol Chem 277:40575-82. 2002
    ..Here we provide evidence that the mannose 6-phosphate/insulin-like growth factor 2 receptor (CD222) controls CD87-mediated functions...
  101. pmc Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2
    Courtney T Griffin
    Department of Genetics and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 102:15173-7. 2005
    ..Moreover, we find that mammalian retromer complexes containing SNX1 and SNX2 have an essential role in embryonic development that is independent of cation-independent mannose 6-phosphate receptor trafficking...

Research Grants3

  1. Mechanisms for immune tolerance in Pompe Disease
    Dwight D Koeberl; Fiscal Year: 2010
    ..These comparisons will guide preclinical experiments to further immunomodulatory gene therapy in Pompe disease and other lysosomal storage disorders. ..
  2. Gene delivery to striated muscle by systemic AAV vectors
    Dwight D Koeberl; Fiscal Year: 2010
    ..Efficacious muscle-targeted gene therapy in GSD-II will have implications for gene therapy in other muscular dystrophies and myopathies. ..
  3. Pathogenesis of autoimmune myositis: Role of MHC Class 1
    Kanneboyina Nagaraju; Fiscal Year: 2009
    ..abstract_text> ..