Ifng

Summary

Gene Symbol: Ifng
Description: interferon gamma
Alias: IFN-g, Ifg, interferon gamma, IFN-gamma, gamma interferon
Species: mouse

Top Publications

  1. pmc An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection
    J L Flynn
    Howard Hughes Medical Institute, Department of Microbiology, Albert Einstein College of Medicine, Bronx, New York 10461
    J Exp Med 178:2249-54. 1993
  2. ncbi Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    Laurie E Harrington
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Immunol 6:1123-32. 2005
  3. pmc A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    Heon Park
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 6:1133-41. 2005
  4. pmc Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
    Roza I Nurieva
    Department of Immunology, University of Texas MD Anderson Cancer Center and Graduate School of Biomedical Sciences, Houston, TX 77030, USA
    Immunity 29:138-49. 2008
  5. pmc Cytokine-secreting follicular T cells shape the antibody repertoire
    R Lee Reinhardt
    Howard Hughes Medical Institute and Departments of Medicine and Microbiology and Immunology, University of California San Francisco, USA
    Nat Immunol 10:385-93. 2009
  6. ncbi Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells
    Susanne J Szabo
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 295:338-42. 2002
  7. doi Type I interferon inhibits interleukin-1 production and inflammasome activation
    Greta Guarda
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Immunity 34:213-23. 2011
  8. ncbi IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge
    Shabaana A Khader
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Nat Immunol 8:369-77. 2007
  9. ncbi Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming
    Alfonso MartIn-Fontecha
    Institute for Research in Biomedicine, 6500 Bellinzona, Switzerland
    Nat Immunol 5:1260-5. 2004
  10. ncbi TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    Marc Veldhoen
    Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
    Immunity 24:179-89. 2006

Research Grants

  1. The regulation of tumor immunity by NKT cells
    Mark Smyth; Fiscal Year: 2007
  2. Investigation of Nod2: Implications for Uveitis
    Holly Rosenzweig; Fiscal Year: 2008
  3. SLC/6Ckine Immunotherapy for Cancer
    Sherven Sharma; Fiscal Year: 2006
  4. Innate Immunity to Cryptosporidium parvum Infection
    BRETT LEAV; Fiscal Year: 2006
  5. Role of T cells in self-limited mucosal infections
    Lynn Bry; Fiscal Year: 2006
  6. A Genetic Determinant of Resistance to HSV
    Edouard Cantin; Fiscal Year: 2006
  7. The stress of dry eye on corneal barrier function
    CINTIA DE PAIVA; Fiscal Year: 2006
  8. Genetic Linkage Analysis of Liver Disease in Mice
    JAMES GORHAM; Fiscal Year: 2006
  9. Innate & adaptive immunities in control of ocular HSV
    Homayon Ghiasi; Fiscal Year: 2007
  10. Early Immune Mechanisms of RSV Pathogenesis
    ALBERT SENFT; Fiscal Year: 2007

Detail Information

Publications221 found, 100 shown here

  1. pmc An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection
    J L Flynn
    Howard Hughes Medical Institute, Department of Microbiology, Albert Einstein College of Medicine, Bronx, New York 10461
    J Exp Med 178:2249-54. 1993
    ..The lymphokine interferon gamma (IFN-gamma) is thought to be a principal mediator of macrophage activation and resistance to intracellular ..
  2. ncbi Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    Laurie E Harrington
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Immunol 6:1123-32. 2005
    ..These findings provide a basis for understanding how inhibition of IFN-gamma signaling enhances development of pathogenic T(H)-17 effector cells that can exacerbate autoimmunity...
  3. pmc A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    Heon Park
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 6:1133-41. 2005
    ..Thus, IL-17 expression characterizes a unique T helper lineage that regulates tissue inflammation...
  4. pmc Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
    Roza I Nurieva
    Department of Immunology, University of Texas MD Anderson Cancer Center and Graduate School of Biomedical Sciences, Houston, TX 77030, USA
    Immunity 29:138-49. 2008
    ..This study thus demonstrates that Tfh is a distinct Th cell lineage...
  5. pmc Cytokine-secreting follicular T cells shape the antibody repertoire
    R Lee Reinhardt
    Howard Hughes Medical Institute and Departments of Medicine and Microbiology and Immunology, University of California San Francisco, USA
    Nat Immunol 10:385-93. 2009
    ..Our findings support a model in which B cells compete for cytokines produced by follicular helper T cells that shape the affinity and isotype of the antibody response...
  6. ncbi Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells
    Susanne J Szabo
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 295:338-42. 2002
    ..This difference is also apparent in the function of these cell subsets. Thus, the regulation of a single cytokine, IFN-gamma, is controlled by distinct transcriptional mechanisms within the T cell lineage...
  7. doi Type I interferon inhibits interleukin-1 production and inflammasome activation
    Greta Guarda
    Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Immunity 34:213-23. 2011
    ..Our findings may thus explain the effectiveness of type I IFN in the treatment of inflammatory diseases but also the observed "weakening" of the immune system after viral infection...
  8. ncbi IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge
    Shabaana A Khader
    Trudeau Institute, Saranac Lake, New York 12983, USA
    Nat Immunol 8:369-77. 2007
    ....
  9. ncbi Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming
    Alfonso MartIn-Fontecha
    Institute for Research in Biomedicine, 6500 Bellinzona, Switzerland
    Nat Immunol 5:1260-5. 2004
    ..Taken together, our results identify an induced pathway of NK cell migration in antigen-stimulated lymph nodes and a mechanism by which some adjuvants may facilitate T(H)1 responses...
  10. ncbi TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    Marc Veldhoen
    Division of Molecular Immunology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
    Immunity 24:179-89. 2006
    ..Our data indicate that, in the presence of IL-6, TGFbeta1 subverts Th1 and Th2 differentiation for the generation of IL-17-producing T cells...
  11. pmc Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
    Edward A Miao
    Institute for Systems Biology, Seattle, Washington, USA
    Nat Immunol 11:1136-42. 2010
    ..This demonstrates that activation of caspase-1 clears intracellular bacteria in vivo independently of IL-1β and IL-18 and establishes pyroptosis as an efficient mechanism of bacterial clearance by the innate immune system...
  12. ncbi Multiple defects of immune cell function in mice with disrupted interferon-gamma genes
    D K Dalton
    Genentech Inc, South San Francisco, CA 94080
    Science 259:1739-42. 1993
    ..Resting splenic natural killer cell activity was reduced in IFN-gamma-deficient mice. Thus, IFN-gamma is essential for the function of several cell types of the murine immune system...
  13. pmc Corneal avascularity is due to soluble VEGF receptor-1
    Balamurali K Ambati
    Department of Ophthalmology, Medical College of Georgia and Augusta Veterans Affairs Medical Center, Augusta, Georgia 30907, USA
    Nature 443:993-7. 2006
    ....
  14. ncbi Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE)
    I A Ferber
    Department of Medicine, Stanford University Medical School, CA 94305, USA
    J Immunol 156:5-7. 1996
    ..We conclude that the presence of IFN-gamma is not crucial to the induction or the clinical course of EAE...
  15. ncbi In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha
    R T Gazzinelli
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 157:798-805. 1996
    ..Together the data suggest that endogenous IL-10 synthesis plays an important role in vivo in down-regulating monokine and IFN-gamma responses to acute intracellular infection, thereby preventing host immunopathology...
  16. ncbi IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis
    Yutaka Komiyama
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Immunol 177:566-73. 2006
    ..These observations indicate that IL-17 rather than IFN-gamma plays a crucial role in the development of EAE...
  17. pmc Inflammatory cytokine-induced intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in mesenchymal stem cells are critical for immunosuppression
    Guangwen Ren
    Department of Molecular Genetics, Microbiology, and Immunology, Robert Wood Johnson Medical School University of Medicine and Dentistry of New Jersey, USA
    J Immunol 184:2321-8. 2010
    ..Taken together, these findings reveal a novel function of adhesion molecules in immunoregulation by MSCs and provide new insights for the clinical studies of antiadhesion therapies in various immune disorders...
  18. pmc The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells
    Guangwei Liu
    Department of Immunology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Nat Immunol 11:1047-56. 2010
    ..Our studies establish an S1P(1)-mTOR axis that controls T cell lineage specification...
  19. ncbi CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasis
    Antonella Mencacci
    Department of Experimental Medicine and Biochemical Science, University of Perugia, Perugia, Italy
    J Immunol 169:3180-90. 2002
    ..These data indicate that alternatively activated PMN expressing CD80 may adversely affect Th1-dependent resistance in fungal infections...
  20. pmc IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells
    Liying Guo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:13463-8. 2009
    ....
  21. pmc Interferon-gamma regulates intestinal epithelial homeostasis through converging beta-catenin signaling pathways
    Porfirio Nava
    Epithelial Pathobiology Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Immunity 32:392-402. 2010
    ..Proliferation was partially restored in IFN-gamma-deficient mice. Thus, we propose that IFN-gamma regulates intestinal epithelial homeostasis by sequential regulation of converging beta-catenin signaling pathways...
  22. pmc Secretion of endoplasmic reticulum aminopeptidase 1 is involved in the activation of macrophages induced by lipopolysaccharide and interferon-gamma
    Yoshikuni Goto
    Laboratory of Cellular Biochemistry, RIKEN, Wako, Saitama, 351 0198, Japan
    J Biol Chem 286:21906-14. 2011
    ..Our data reveal ERAP1-mediated activation of macrophages for the first time and will provide new insights into the role of this enzyme in innate immunity...
  23. pmc Myeloid STAT3 inhibits T cell-mediated hepatitis by regulating T helper 1 cytokine and interleukin-17 production
    Fouad Lafdil
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland
    Gastroenterology 137:2125-35.e1-2. 2009
    ..The aim of this study was to investigate the immune cell-signaling pathways involved-specifically the role of signal transducer and activator of transcription 3 (STAT3)-in T cell-mediated hepatitis in mice...
  24. ncbi Interferon-gamma confers resistance to experimental allergic encephalomyelitis
    M Krakowski
    Department of Microbiology and Immunology, McGill University, Montreal, Canada
    Eur J Immunol 26:1641-6. 1996
    ..We thus demonstrate that lack of IFN-gamma converts an otherwise EAE-resistant mouse strain to become susceptible to disease. Therefore, in BALB/c mice, IFN-gamma confers resistance to EAE...
  25. ncbi IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis
    D O Willenborg
    Neuroscience Research Unit, The Canberra Hospital, Australia
    J Immunol 157:3223-7. 1996
    ..These results indicate that IFN-gamma is not essential for the generation or function of anti-MOG35-55 effector cells but does play an important role in down-regulating EAE at both the effector and induction phase of disease...
  26. ncbi In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection
    T M Scharton-Kersten
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 157:4045-54. 1996
    ..gondii: IL-12 precedes and initiates synthesis of IFN-gamma, while the latter lymphokine directly controls parasite growth and diminishes the contribution of IL-4- and IL-5-producing T cell subsets...
  27. ncbi Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice
    Erika Cretney
    Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Institute, A Beckett Street, East Melbourne, 8006 Victoria, Australia
    J Immunol 168:1356-61. 2002
    ..TRAIL gene-targeted mice were also more sensitive to the chemical carcinogen methylcholanthrene. These results substantiated TRAIL as an important natural effector molecule used in the host defense against transformed cells...
  28. ncbi Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasis
    S E Street
    Cancer Immunology, Peter MacCallum Cancer Institute, Victoria, Australia
    Blood 97:192-7. 2001
    ....
  29. pmc T helper 1 cells stimulated with ovalbumin and IL-18 induce airway hyperresponsiveness and lung fibrosis by IFN-gamma and IL-13 production
    Nobuki Hayashi
    Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Hyogo 663 8501, Japan
    Proc Natl Acad Sci U S A 104:14765-70. 2007
    ..Thus, IL-18 becomes a key target molecule for the development of a therapeutic regimen for the treatment of Th1-cell-induced bronchial asthma...
  30. ncbi A novel role for neutrophils as a source of T cell-recruiting chemokines IP-10 and Mig during the DTH response to HSV-1 antigen
    S J Molesworth-Kenyon
    Department of Microbiology and Immunology, University of South Alabama, Mobile, AL 36607, USA
    J Leukoc Biol 77:552-9. 2005
    ..Collectively, our results support the hypothesis that neutrophil production of T cell-recruiting chemokines contributes to the regulation and amplification of the DTH response...
  31. pmc Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells
    Suk Jo Kang
    Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0795, USA
    Immunity 29:819-33. 2008
    ..Thus, spatial organization of the immune response by DCs between 6 and 24 hr ensures functional activation of innate cells, which restricts pathogens before adaptive immunity is fully activated...
  32. pmc The cell-specific induction of CXC chemokine ligand 9 mediated by IFN-gamma in microglia of the central nervous system is determined by the myeloid transcription factor PU.1
    Sally L Ellis
    School of Molecular Bioscience and Bosch Institute, University of Sydney, Sydney, New South Wales, Australia
    J Immunol 185:1864-77. 2010
    ..Thus, PU.1 not only is crucial for the induction of CXCL9 by IFN-gamma in microglia but also is a key determinant factor for the cell-specific expression of this chemokine by these myeloid cells...
  33. pmc CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs
    Jie Sun
    The Beirne B Carter Center for Immunology Research, The University of Virginia, Charlottesville, Virginia, USA
    Nat Immunol 12:327-34. 2011
    ..These findings reveal a previously unrecognized pathway that coordinates signals derived from innate and helper T cells to control the production of a regulatory cytokine by CTLs during acute viral infection...
  34. pmc Silencing suppressor of cytokine signaling-1 (SOCS1) in macrophages improves Mycobacterium tuberculosis control in an interferon-gamma (IFN-gamma)-dependent manner
    Berit Carow
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm 17177, Sweden
    J Biol Chem 286:26873-87. 2011
    ..tuberculosis clearance early after infection in vivo in an IFN-γ-dependent manner. On the other hand, at later time points, SOCS1 expression by non-macrophage cells protected the host from infection-induced detrimental inflammation...
  35. pmc Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1β
    Bibhuti B Mishra
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nat Immunol 14:52-60. 2013
    ..Our data indicate that the NO produced as a result of adaptive immunity is indispensable in modulating the destructive innate inflammatory responses elicited during persistent infections...
  36. pmc IFN-γ inhibits gastric carcinogenesis by inducing epithelial cell autophagy and T-cell apoptosis
    Shui Ping Tu
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, USA
    Cancer Res 71:4247-59. 2011
    ....
  37. pmc IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis
    Michele W L Teng
    Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    Proc Natl Acad Sci U S A 107:8328-33. 2010
    ..Overall, these data indicate the general role that IL-23 plays in suppressing natural or cytokine-induced innate immunity, promoting tumor development and metastases independently of IL-17A...
  38. pmc Interferon gamma derived from CD4(+) T cells is sufficient to mediate T helper cell type 1 development
    A E Wakil
    Department of Medicine and the Department of Microbiology Immunology, University of California San Francisco, San Francisco, California 94143, USA
    J Exp Med 188:1651-6. 1998
    b>Interferon gamma (IFN-gamma) has been implicated in T helper type 1 (Th1) cell development through its ability to optimize interleukin 12 (IL-12) production from macrophages and IL-12 receptor expression on activated T cells...
  39. pmc IFN-gamma- and TNF-dependent bystander eradication of antigen-loss variants in established mouse cancers
    Bin Zhang
    Department of Pathology and Committee on Immunology, University of Chicago, Chicago, Illinois, USA
    J Clin Invest 118:1398-404. 2008
    ..Therefore, bystander killing of ALVs may result from IFN-gamma and TNF acting on tumor stroma...
  40. pmc Induction of lectin-like transcript 1 (LLT1) protein cell surface expression by pathogens and interferon-γ contributes to modulate immune responses
    Claire Germain
    Institut de Pharmacologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Université de Nice Sophia Antipolis, UMR6097, 06560 Valbonne, France
    J Biol Chem 286:37964-75. 2011
    ..Altogether, our results point toward a role for LLT1/CD161 in modulating immune responses to pathogens...
  41. ncbi NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses
    Tomohiro Watanabe
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10 Room 11N238, 10 Center Drive, Bethesda, Maryland 20892, USA
    Nat Immunol 5:800-8. 2004
    ..Thus, CARD15 mutations may lead to disease by causing excessive T(H)1 responses...
  42. doi CCR6 and NK1.1 distinguish between IL-17A and IFN-gamma-producing gammadelta effector T cells
    Jan D Haas
    Hannover Medical School, Institute for Immunology, Hannover, Germany
    Eur J Immunol 39:3488-97. 2009
    ..1+ counterparts. In conclusion, our findings support the hypothesis that CCR6+ IL-17A-producing gammadelta T cells derive from less TCR-dependent selection events than IFN-gamma-producing NK1.1+ gammadelta T cells...
  43. ncbi Endothelial programmed death-1 ligand 1 (PD-L1) regulates CD8+ T-cell mediated injury in the heart
    Nir Grabie
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Circulation 116:2062-71. 2007
    ..PD-L1 is induced on cardiac endothelial cells under inflammatory conditions, but little is known about its role in regulating immune injury in the heart...
  44. ncbi Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-gamma on STAT3 and Smads
    Kentaro Tanaka
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    J Immunol 180:3746-56. 2008
    ..SOCS1-deficient T cells will be very useful to investigate the molecular mechanism for the STAT1-mediated suppression of Th17 development...
  45. ncbi Silencing T-bet defines a critical role in the differentiation of autoreactive T lymphocytes
    Amy E Lovett-Racke
    Department of Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 USA
    Immunity 21:719-31. 2004
    ..Since T-bet regulates IFNgamma production in CD4(+) T cells, but to a lesser extent in most other IFNgamma-producing cells, T-bet may be a target for therapeutics for Th1-mediated diseases...
  46. ncbi IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance
    Teresa Zelante
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Eur J Immunol 37:2695-706. 2007
    ..As IL-23-driven inflammation promotes infection and impairs antifungal resistance, modulation of the inflammatory response represents a potential strategy to stimulate protective immune responses to fungi...
  47. ncbi A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells
    Amit Awasthi
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, USA
    Nat Immunol 8:1380-9. 2007
    ..Thus, IL-27 and transforming growth factor-beta promote the generation of IL-10-producing Tr1 cells...
  48. doi Suppressor of cytokine signaling-1 ameliorates dextran sulfate sodium-induced colitis in mice
    Jiro Horino
    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Int Immunol 20:753-62. 2008
    ..Our findings suggest that SOCS-1, particularly in T cells, prevents the development of DSS-induced colitis in mice by inhibiting IFN-gamma/STAT1 signaling and by subsequently regulating Treg cell development...
  49. pmc Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection
    C M Collazo
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 194:181-8. 2001
    ..In addition, both strains displayed normal clearance of MCMV. Thus, LRG-47 and IRG-47 have vital, but distinct roles in immune defense against protozoan and bacterial infections...
  50. pmc Perforin and gamma interferon-mediated control of coronavirus central nervous system infection by CD8 T cells in the absence of CD4 T cells
    Cornelia C Bergmann
    Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Virol 78:1739-50. 2004
    ..The contributions of perforin-mediated cytolysis and gamma interferon (IFN-gamma) secretion by CD8(+) T cells to the control of infection and the induction of demyelination were ..
  51. pmc Interferon gamma enhances both in vitro and in vivo priming of CD4+ T cells for IL-4 production
    Petr Bocek
    Division of Allergy, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 6610 Rockledge Dr, Rm 3060, Bethesda, MD 20892, USA
    J Exp Med 199:1619-30. 2004
    ..Thus, IFNgamma plays an unanticipated but substantial role in Th2 priming, although it is an important Th1 cytokine, and under certain circumstances a Th1 inducer...
  52. ncbi CXCR3, IP-10, and Mig are required for CD4+ T cell recruitment during the DTH response to HSV-1 yet are independent of the mechanism for viral clearance
    Sara Molesworth-Kenyon
    Department of Microbiology and Immunology, University of South Alabama, Mobile, AL 36607, USA
    Virology 333:1-9. 2005
    ..Collectively, these results suggest that in the sensitized host, CXCR3, IP-10, and Mig are required for optimal DTH responsiveness but are not essential for containing HSV-1 replication in the ear pinna...
  53. pmc SOCS-1 regulates IL-15-driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential
    Gayle M Davey
    The Walter and Eliza Hall Institute of Medical Research, Parkville, 3050 Victoria, Australia
    J Exp Med 202:1099-108. 2005
    ..Therefore, impaired deletion of highly autoreactive CD8 T cells, together with uncontrolled activation of naive CD8 T cells by homeostatic survival ligands, may provide a basis for the T cell-mediated disease of SOCS-1-/- mice...
  54. ncbi Interferon-gamma promotes differentiation of neural progenitor cells via the JNK pathway
    So Jung Kim
    Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Longevity Life Science and Technology Institutes, Pusan National University, Geumjeong Gu, Busan, Korea
    Neurochem Res 32:1399-406. 2007
    ..Our findings show that the pro-inflammatory cytokine, IFN-gamma has the potential to stimulate neurogenesis, suggesting roles for this cytokine in development and repair of the nervous system...
  55. ncbi Lipopolysaccharide, IFN-gamma, and IFN-beta induce expression of the thiol-sensitive ART2.1 Ecto-ADP-ribosyltransferase in murine macrophages
    Shiyuan Hong
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44120, USA
    J Immunol 179:6215-27. 2007
    ..Collectively, these studies identify ART2.1 as a new candidate for linking autocrine/paracrine activation of inflammatory macrophages to the release of NAD, a critical intracellular metabolite...
  56. ncbi IL-17 receptor signaling influences virus-induced corneal inflammation
    Sara J Molesworth-Kenyon
    Department of Microbiology and Immunology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA
    J Leukoc Biol 83:401-8. 2008
    ..Thus, IL-17 actively influences early virus-induced corneal inflammation...
  57. pmc Reciprocal interaction between macrophages and T cells stimulates IFN-γ and MCP-1 production in Ang II-induced cardiac inflammation and fibrosis
    Ya Lei Han
    Beijing An Zhen Hospital, Capital Medical University, Beijing, China
    PLoS ONE 7:e35506. 2012
    ..The inflammatory response plays a critical role in hypertension-induced cardiac remodeling. We aimed to study how interaction among inflammatory cells causes inflammatory responses in the process of hypertensive cardiac fibrosis...
  58. ncbi Cloning and characterization of a novel cDNA that is IFN-gamma-induced in mouse peritoneal macrophages and encodes a putative GTP-binding protein
    W P Lafuse
    Department of Medical Microbiology and Immunology, Ohio State University, Columbus 43210
    J Leukoc Biol 57:477-83. 1995
    ..IRG-47 encodes an intracellular protein that contains three conserved protein motifs present in GTP-binding proteins. Analysis of the protein sequence of Mg21 showed that these three conserved protein motifs are also present in Mg21...
  59. pmc Response to influenza infection in mice with a targeted disruption in the interferon gamma gene
    M B Graham
    Beirne B, Carter Center for Immunology Research, University of Virginia Health Sciences Center, Charlottesville 22908
    J Exp Med 178:1725-32. 1993
    b>Interferon gamma (IFN-gamma) is a pleiotropic cytokine secreted by T lymphocytes and natural killer (NK) cells and has been noted to be a first line of host defense in the control of viral infections...
  60. ncbi IL-12 induces IFN-gamma expression and secretion in mouse peritoneal macrophages
    P Puddu
    Laboratorie of Immunology, Istituto Superiore di Sanita, Rome, Italy
    J Immunol 159:3490-7. 1997
    ..We suggest that IL-12-induced IFN-gamma production by macrophages can play some role in the generation of the antiviral and immunoregulatory effects of IL-12...
  61. ncbi Inflammation and lymphocyte activation during mycobacterial infection in the interferon-gamma-deficient mouse
    J E Pearl
    Mycobacterial Research Laboratories, Colorado State University, Fort Collins, Colorado 80523, USA
    Cell Immunol 211:43-50. 2001
    ..This role may be key in surviving the kind of chronic stimulatory disease caused by Mycobacterium tuberculosis...
  62. pmc Interferon-gamma protects against chronic viral myocarditis by reducing mast cell degranulation, fibrosis, and the profibrotic cytokines transforming growth factor-beta 1, interleukin-1 beta, and interleukin-4 in the heart
    Delisa Fairweather
    Department of Pathology, Johns Hopkins Medical Institutions, 720 Rutland Ave, Baltimore, MD 21205, USA
    Am J Pathol 165:1883-94. 2004
    ....
  63. pmc The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum
    Eszter Lazar-Molnar
    Departments of Microbiology and Immunology, Albert Einstein College of Medicine, Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 105:2658-63. 2008
    ..The results show that the PD-1/PD-L pathway has a key role in the regulation of antifungal immunity, and suggest that manipulation of this pathway represents a strategy of immunotherapy for histoplasmosis...
  64. doi A heat shock protein gene (Hsp70.1) is critically involved in the generation of the immune response to myelin antigen
    Marcin P Mycko
    Department of Neurology, Laboratory of Neuroimmunology, Medical University of Lodz, 22 Kopcinskiego Street, Lodz, Poland
    Eur J Immunol 38:1999-2013. 2008
    ....
  65. pmc Mice with a selective impairment of IFN-gamma signaling in macrophage lineage cells demonstrate the critical role of IFN-gamma-activated macrophages for the control of protozoan parasitic infections in vivo
    Jennifer E Lykens
    Division of Immunobiology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    J Immunol 184:877-85. 2010
    ..Thus, the MIIG mouse formally demonstrates for the first time in vivo, the specific importance of direct, IFN-gamma mediated activation of macrophages for controlling infection with multiple protozoan parasites...
  66. pmc Disseminated tuberculosis in interferon gamma gene-disrupted mice
    A M Cooper
    Department of Microbiology, Colorado State University, Fort Collins 80523
    J Exp Med 178:2243-7. 1993
    ..Among these cytokines, interferon gamma (IFN-gamma) is believed to play a key role is these events...
  67. ncbi Potent inhibition of macrophage responses to IFN-gamma by live virulent Mycobacterium tuberculosis is independent of mature mycobacterial lipoproteins but dependent on TLR2
    Niaz Banaiee
    Department of Medicine, Division of Infectious Diseases, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 176:3019-27. 2006
    ..These results establish that M. tuberculosis possesses multiple mechanisms of inhibiting responses to IFN-gamma...
  68. pmc Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice
    Jiusong Sun
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 117:3359-68. 2007
    ....
  69. ncbi Suppressor of cytokine signaling-1 regulates inflammatory bowel disease in which both IFNgamma and IL-4 are involved
    Takatoshi Chinen
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Gastroenterology 130:373-88. 2006
    ..However, the role of SOCS1 in inflammatory bowel diseases (IBDs) has not been clarified. To determine the role of SOCS1 in colitis, we generated SOCS1/T-cell receptor alpha (TCRalpha) double knockout (DKO) mice...
  70. doi IFN-gamma enhances neurogenesis in wild-type mice and in a mouse model of Alzheimer's disease
    Rona Baron
    The Shraga Segal Dept of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    FASEB J 22:2843-52. 2008
    ..We demonstrate that limited amounts of IFN-gamma in the brain shape the neuropoietic milieu to enhance neurogenesis, possibly representing the normal function of the immune system in controlling brain inflammation and repair...
  71. doi Immune-mediated mechanisms of parasite tissue sequestration during experimental cerebral malaria
    Fiona H Amante
    Australian Centre for Vaccine Development, Brisbane, Queensland, Australia
    J Immunol 185:3632-42. 2010
    ..These findings provide novel insights into immune-mediated mechanisms of ECM pathogenesis and highlight the potential of T cells to both prevent and promote infectious diseases...
  72. pmc Differential effects of the absence of interferon-gamma and IL-4 in acute graft-versus-host disease after allogeneic bone marrow transplantation in mice
    W J Murphy
    SAIC Frederick, Division of Basic Science, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
    J Clin Invest 102:1742-8. 1998
    ..These results therefore indicate, with regard to the TH1/ TH2 cytokine paradigm, the absence of a TH1-type cytokine can be deleterious in acute GVHD, whereas absence of a TH2 cytokine can be protective...
  73. ncbi Genetic regulation of autoimmune disease: BALB/c background TGF-beta 1-deficient mice develop necroinflammatory IFN-gamma-dependent hepatitis
    J D Gorham
    Department of Pathology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 166:6413-22. 2001
    ..This represents the first murine model of hepatitis that develops spontaneously, is restricted by genetic background, and is dependent upon the Th1 cytokine IFN-gamma, and that thus recapitulates these important aspects of AIH...
  74. ncbi Persistence of lesions in suppressor of cytokine signaling-1-deficient mice infected with Leishmania major
    Denise V R Bullen
    The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Center for Cellular Growth Factors, Royal Melbourne Hospital, Victoria, Australia
    J Immunol 170:4267-72. 2003
    ..These results suggest that SOCS1 plays an important role in the regulation of appropriate inflammatory responses during the resolution of L. major infection...
  75. ncbi IL-12 receptor beta 1 and Toll-like receptor 4 increase IL-1 beta- and IL-18-associated myocarditis and coxsackievirus replication
    Delisa Fairweather
    Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA
    J Immunol 170:4731-7. 2003
    ..These findings have important implications not only for the pathogenesis of myocarditis, but for other autoimmune diseases triggered by viral infections...
  76. ncbi Long-term suppression of tumor growth by TNF requires a Stat1- and IFN regulatory factor 1-dependent IFN-gamma pathway but not IL-12 or IL-18
    Terry H Wu
    Department of Pathology, Committee on Cancer Biology, Department of Health Studies, University of Chicago, Chicago, IL 60637, USA
    J Immunol 172:3243-51. 2004
    ..These results strongly suggest a novel function for the endogenous IFN-gamma pathway that without measurable IFN-gamma production or activity affects the ability of TNF to suppress tumor development...
  77. ncbi Intercellular adhesion molecule 1 deficiency leads to impaired recruitment of T lymphocytes and enhanced host susceptibility to infection with Trypanosoma cruzi
    Vladimir Michailowsky
    Laboratory of Immunopathology, Centro de Pesquisas René Rachou Fundação Oswaldo Cruz, Belo Horizonte, Brazil
    J Immunol 173:463-70. 2004
    ..Therefore, we favor the hypothesis that ICAM-1 plays a crucial role in T lymphocyte recruitment to the cardiac tissue and host susceptibility during T. cruzi infection...
  78. ncbi TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver
    Kazuyoshi Takeda
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bukyou ku, Tokyo 113 8421, Japan
    Blood 105:2082-9. 2005
    ..On birth and with age, NK cells develop full functional capacity, including the ability to secrete interferon gamma (IFN-gamma) and interleukin 13 (IL-13) and mediate perforin- and Fas ligand-mediated cytotoxicity...
  79. ncbi Regulation of IFN-gamma production by B effector 1 cells: essential roles for T-bet and the IFN-gamma receptor
    David P Harris
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 174:6781-90. 2005
    ....
  80. pmc Interferon-gamma plays protective roles in sodium arsenite-induced renal injury by up-regulating intrarenal multidrug resistance-associated protein 1 expression
    Akihiko Kimura
    Department of Forensic Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8509, Japan
    Am J Pathol 169:1118-28. 2006
    ..Thus, IFN-gamma can protect against NaAs-induced acute renal injury, probably by maintaining Nrf2-mediated intrarenal MRP1 gene expression...
  81. pmc Gamma interferon suppresses erythropoiesis via interleukin-15
    Isis K Mullarky
    Trudeau Institute, Saranac Lake, New York, USA
    Infect Immun 75:2630-3. 2007
    ..In studies of the underlying mechanisms researchers have increasingly focused on gamma interferon (IFN-gamma)...
  82. ncbi Airway exposure levels of lipopolysaccharide determine type 1 versus type 2 experimental asthma
    Yoon Keun Kim
    Department of Life Science, Postech Biotech Center, Pohang University of Science and Technology, Namgu, Pohang, Gyeongbuk, Republic of Korea
    J Immunol 178:5375-82. 2007
    ..These findings suggest that airway exposure levels of LPS induces different forms of asthma that are type 1 and type 2 asthma phenotypes by high and low LPS levels, respectively...
  83. ncbi NK cells stimulate recruitment of CXCR3+ T cells to the brain during Plasmodium berghei-mediated cerebral malaria
    Diana S Hansen
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Immunol 178:5779-88. 2007
    ....
  84. pmc Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin
    Andrew M Intlekofer
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 321:408-11. 2008
    ..T-bet and Eomes, thus, ensure that CD8+ T cells adopt an appropriate course of intracellular rather than extracellular destruction...
  85. pmc IFN-gamma induces the erosion of preexisting CD8 T cell memory during infection with a heterologous intracellular bacterium
    Renu Dudani
    National Research Council Institute for Biological Sciences, Ottawa, Ontario, Canada
    J Immunol 181:1700-9. 2008
    ..Although IFN-gamma promotes the control of intracellular bacterial replication during primary infection, this comes at the expense of erosion of preexisting memory CD8(+) T cells in the wake of infection with heterologous pathogens...
  86. pmc Lymphoid-related CD11c+ CD8alpha+ dendritic cells are involved in enhancing herpes simplex virus type 1 latency
    Kevin R Mott
    Center for Neurobiology and Vaccine Development, D2024, Cedars Sinai Burns and Allen Research Institute, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    J Virol 82:9870-9. 2008
    ..Our results suggest that CD11c(+) CD8alpha(+) DCs directly or indirectly increase the amount of HSV-1 latency in mouse TGs...
  87. doi Dominance of cytokine- over FasL-induced impairment of the mitochondrial transmembrane potential (Deltapsim) in the pancreatic beta-cell line NIT-1
    Petra Augstein
    Institute of Diabetes Gerhardt Katsch Karlsburg e V, Karlsburg, Germany
    Diab Vasc Dis Res 5:198-204. 2008
    ..Furthermore, at least in NIT-1 cells, the extrinsic FasL/Fas pathway has only a minor additive effect on cytokine-induced Deltapsim impairment...
  88. pmc Follistatin-like protein 1 promotes arthritis by up-regulating IFN-gamma
    Suzanne D Clutter
    Division of Rheumatology, Children s Hospital of Pittsburgh, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213, USA
    J Immunol 182:234-9. 2009
    ..These findings demonstrate that FSTL-1 plays a critical role in arthritis by enhancing IFN-gamma signaling pathways and suggest a mechanism by which FSTL-1 bridges innate and adaptive immune responses...
  89. doi Macrophage oxygen sensing modulates antigen presentation and phagocytic functions involving IFN-gamma production through the HIF-1 alpha transcription factor
    Barbara Acosta-Iborra
    Servicio de Inmunologia, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Madrid, Spain
    J Immunol 182:3155-64. 2009
    ..Our data underscore an important role of hypoxia in the activation of macrophage cytokine production, Ag-presenting activity, and phagocytic activity due to an HIF-1alpha-mediated increase in IFN-gamma levels...
  90. doi Pulmonary suppressor of cytokine signaling-1 induced by IL-13 regulates allergic asthma phenotype
    Satoru Fukuyama
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Am J Respir Crit Care Med 179:992-8. 2009
    ....
  91. doi Brief report: interferon-gamma induces expansion of Lin(-)Sca-1(+)C-Kit(+) Cells
    Xin Zhao
    Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA
    Stem Cells 28:122-6. 2010
    ..Therefore, our findings demonstrated a novel role of IFNgamma in activating hematopoietic progenitor cells and provide a new insight into the clinical application of interferon...
  92. doi Anti-programmed cell death 1 antibody reduces CD4+PD-1+ T cells and relieves the lupus-like nephritis of NZB/W F1 mice
    Shimpei Kasagi
    Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Kobe, Hyogo 650 0017, Japan
    J Immunol 184:2337-47. 2010
    ..We conclude that CD4(+)PD-1(high) T cells are dysregulated IFN-gamma-producing, proinflammatory cells in NZB/W F1 mice...
  93. pmc Cutting edge: IFN-gamma is a negative regulator of IL-23 in murine macrophages and experimental colitis
    Shehzad Z Sheikh
    Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    J Immunol 184:4069-73. 2010
    ..Converging genetic and functional findings suggest that IL-23 and IFN-gamma are important pathogenic molecules in human inflammatory bowel disease...
  94. pmc Regulation of interleukin-1beta by interferon-gamma is species specific, limited by suppressor of cytokine signalling 1 and influences interleukin-17 production
    Seth L Masters
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    EMBO Rep 11:640-6. 2010
    ..In mice, IFNgamma decreased IL-1beta and subsequently IL-17, indicating that the adaptive immune response can provide a systemic, but transient, signal to limit inflammation...
  95. pmc Impaired phagocytosis of apoptotic cells by macrophages in chronic granulomatous disease is reversed by IFN-γ in a nitric oxide-dependent manner
    Ruby Fernandez-Boyanapalli
    National Jewish Health, Denver, CO 80206, USA
    J Immunol 185:4030-41. 2010
    ..These data support the hypothesis that in addition to correcting immunodeficiency in CGD, IFN-γ priming of Ms restores clearance of apoptotic cells and may thereby contribute to resolution of exaggerated CGD inflammation...
  96. pmc IFN-γ upregulates survivin and Ifi202 expression to induce survival and proliferation of tumor-specific T cells
    Mary Zimmerman
    Department of Biochemistry and Molecular Biology, Medical College of Georgia, Georgia Health Sciences University, Augusta, Georgia, USA
    PLoS ONE 5:e14076. 2010
    ..The aim of this study is to elucidate the molecular mechanisms underlying the effects of stimulation conditions on proliferation and survival of tumor-specific CTLs...
  97. pmc The central role of CD4(+) T cells in the antitumor immune response
    K Hung
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Exp Med 188:2357-68. 1998
    ..Cytokines produced by these CD4(+) T cells activate eosinophils as well as macrophages that produce both superoxide and nitric oxide. Both of these cell types then collaborate within the site of tumor challenge to cause its destruction...
  98. ncbi Involvement of interferon-gamma in microglial-mediated loss of dopaminergic neurons
    Matthew P Mount
    Ottawa Health Research Institute, Neuroscience Group, Ottawa, Ontario, Canada K1H 8M5
    J Neurosci 27:3328-37. 2007
    ..Finally, levels of IFN-gamma message increased in microglia in response to rotenone. Together, these data suggest that IFN-gamma participates in death of dopaminergic neurons by regulating microglial activity...
  99. ncbi TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties
    T R Mosmann
    DNAX Research Institute, Palo Alto, California 94304
    Annu Rev Immunol 7:145-73. 1989
  100. ncbi IL-12 stimulates an antiviral type 1 cytokine response but lacks adjuvant activity in IFN-gamma-receptor-deficient mice
    V E Schijns
    Department of Infectious Diseases and Immunology, Veterinary Faculty, Ultrecht University, The Netherlands
    J Immunol 155:2525-32. 1995
    ..In wild-type mice administration of recombinant IFN-gamma but not IL-2 mimicked the immune-stimulating activity of IL-12; it is therefore likely that the IL-12 adjuvant activity is largely mediated by physiologic IFN-gamma...
  101. pmc CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major
    Z E Wang
    Department of Medicine, University of California San Francisco 94143
    J Exp Med 179:1367-71. 1994
    Mice with homologous disruption of the interferon gamma (IFN-gamma) gene on the C57BL/6 background were infected with Leishmania major and the immune response assessed...

Research Grants60

  1. The regulation of tumor immunity by NKT cells
    Mark Smyth; Fiscal Year: 2007
    ..This proposal focuses clearly on a pivotal immune control mechanism that will influence many current and future immunotherapies. ..
  2. Investigation of Nod2: Implications for Uveitis
    Holly Rosenzweig; Fiscal Year: 2008
    ..Together, these studies will provide valuable new information on how Nod2 is involved in autoimmunity and the pathogeneis of uveitis. ..
  3. SLC/6Ckine Immunotherapy for Cancer
    Sherven Sharma; Fiscal Year: 2006
    ..B) The importance of cytokines IFN gamma, IL-10, GM-CSF, IL-12, MIG and IP10 in SLC- mediated anti-tumor responses will be assessed. 2...
  4. Innate Immunity to Cryptosporidium parvum Infection
    BRETT LEAV; Fiscal Year: 2006
    ..Scid mice are initially resistant to Cp infection through an interferon gamma (IFNy)-dependent mechanism...
  5. Role of T cells in self-limited mucosal infections
    Lynn Bry; Fiscal Year: 2006
    ..This training provides a necessary step in the candidate's goal to become an independent researcher investigating questions in mucosal immunology and host-microbial cross-talk in intestinal environments. ..
  6. A Genetic Determinant of Resistance to HSV
    Edouard Cantin; Fiscal Year: 2006
    ..abstract_text> ..
  7. The stress of dry eye on corneal barrier function
    CINTIA DE PAIVA; Fiscal Year: 2006
    ..TJ and LEP expression will be evaluated by laser scanning confocal microscopy and immunostaining. Pro inflammatory mediator expression will be evaluated by Western Blot, ELISA and the Luminex Multiplex Assay. [unreadable] [unreadable]..
  8. Genetic Linkage Analysis of Liver Disease in Mice
    JAMES GORHAM; Fiscal Year: 2006
    ..This will have important implications for understanding the genetic basis of autoimmune hepatitis, and of hepatocellular damage in the settings of HCV infection. ..
  9. Innate & adaptive immunities in control of ocular HSV
    Homayon Ghiasi; Fiscal Year: 2007
    ....
  10. Early Immune Mechanisms of RSV Pathogenesis
    ALBERT SENFT; Fiscal Year: 2007
    ..In the long term, these studies will improve our understanding of the immune regulation and the pathogenesis of RSV infection, and may lead to novel therapies for RSV-induced airway disease. [unreadable] [unreadable]..
  11. Interferon gamma Dependent Innate Immunity to Cryptosporidium parvum
    WARD HONORINE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  12. Innate immune evasion and/or antagonism by eastern equine encephalitis virus
    KATHERINE RYMAN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  13. Control of Dendritic Cell Generation and Function by Tumor
    Michael Shurin; Fiscal Year: 2008
    ..Additionally, understanding the mechanisms responsible for DC dysfunction in cancer will serve as a basis for developing novel therapeutic approaches for patients with cancer. ..
  14. GP63 EXPRESSION IN LEISHMANIA CHAGASI
    Mary Wilson; Fiscal Year: 2001
    ..They will also provide a model for differential expression of tandemly linked genes in this group of protozoa. ..
  15. KILLER CELLS AND ALCOHOL
    ZUHAIR BALLAS; Fiscal Year: 2008
    ..Preliminary data prompted the hypothesis that ETOH blunts the enhanced NK activity induced by CpG ODN [unreadable] [unreadable]..
  16. IMMUNE PROMOTION OF REMYELINATION
    Moses Rodriguez; Fiscal Year: 2008
    ..Our findings are expected to provide new insights into the enhancement of remyelination in diseases such as multiple sclerosis. [unreadable] [unreadable]..
  17. Cell Cycle Inhibition in Systemic Autoimmunity
    DWIGHT KONO; Fiscal Year: 2009
    ..These studies should yield important new insights into the significance and role of p21 in systemic autoimmunity and in host response to foreign antigens. ..
  18. PATHOGENESIS OF MURINE SYSTEMIC LUPUS ERYTHEMATOSUS
    DWIGHT KONO; Fiscal Year: 2009
    ..Identification of the susceptibility genes and elucidation of their roles in the induction of lupus should provide significant insights into the etiopathogenesis of genetically-determined autoimmune diseases. ..
  19. Vein wall remodeling after DVT is matrix metalloproteinase dependent
    Peter Henke; Fiscal Year: 2009
    ..This proposal will provide important mechanistic insight into the pathophysiology of post-phelbitic syndrome with real potential translation to decreasing the morbidity from this under-acknowledged disease. ..
  20. Ocular Regulation of Autoimmunity
    ROBERT CONE; Fiscal Year: 2009
    ..The results of this study could aid our understanding of the systemic basis for the ocular regulation of autoimmunity and develop procedures for the modulation of active autoimmune disease. ..
  21. Collaborative Development of a Vaccine against Cutaneous and Visceral Leishmanias
    MARY EDYTHE WILSON; Fiscal Year: 2010
    ..Through a coordinated approach in the three laboratories, we will systematically perform pre-clinical testing against several Leishmania species, with the goal of developing a pan-leishmania protective vaccine. ..
  22. Thymic Influence on Ocular Immunoregulation
    Robert E Cone; Fiscal Year: 2010
    ....
  23. IL-2 Suppression by Endocannabinoid Activation of PPARgamma
    NORBERT EDWARD KAMINSKI; Fiscal Year: 2010
    ....
  24. Genetic control of renal disease in lupus-prone mice
    Marcia McDuffie; Fiscal Year: 2010
    ..We expect that these studies will lead to improved understanding of the process and possibly will lead to novel therapeutic strategies for prevention of this devastating complication. ..
  25. Ocular HSV: Role of virus and IL-2 in Optic neuritis
    Homayon Ghiasi; Fiscal Year: 2010
    ..3. Determine if a recombinant HSV-1 expressing IL-4 (HSV-IL-4) can protect against HSV-IL-2-induced demyelination, while a similarly made recombinant virus expressing IFN-gamma is not beneficial. ..
  26. Thrombus resolution is CXC chemokine dependent
    Peter Henke; Fiscal Year: 2006
    ..abstract_text> ..
  27. The Major Surface Protease of Trypanosomatid Protozoa
    Mary Wilson; Fiscal Year: 2003
    ..chagasi whose coding sequences predict they lack the usual GPI anchor, and to contrast the amino acid sequences that regulate the intracellular trafficking of these unusual MSPs with the MSPs that possess a GPI membrane anchor. ..
  28. TRANSPLANT IMMUNOLOGY OF IL2 IFNY DOUBLE KNOCKOUT MICE
    Martin Zand; Fiscal Year: 2002
    ..Intragraft expression of the cytokines interleukin 2 and interferon gamma (IFN-gamma) has been found to be markers for clinical and experimental allograft rejection...
  29. TGFB1 GENE TRANSFER IN VASCULARIZED CARDIAC ALLOGRAFTS
    D Bishop; Fiscal Year: 2003
    ..This study will provide insight for optimizing immunosuppressive gene therapy in clinical transplantation. ..
  30. REPRESSION OF T CELL ACTIVATION BY ENDOCANNABINOIDS
    Norbert Kaminski; Fiscal Year: 2003
    ..In SA#4 we will characterize the direct effects of Ana and 2-Ara-Gl on PKC and MAP kinase activity. ..
  31. CELLULAR PATHWAYS OF OCULAR IMMUNOREGULATION
    ROBERT CONE; Fiscal Year: 2003
    ..Understanding of this axis could impact on the management o f inflammatory eye disease, organ transplants (e.g. cornea), ocular tumors and autoimmune disease. ..
  32. CAPACITATIVE CALCIUM ENTRY DEFECT IN IMMUNE DEFICIENCY
    Anjana Rao; Fiscal Year: 2002
    ..Deletion mapping using spectral karyotyping and microsatellite markers will be used to further narrow down the chromosomal region involved in the defect and candidate genes in this region will be evaluated. ..
  33. CD40-CD154 Interactions in Cryptosporidial Immunity
    ESTHER PONNURAJ; Fiscal Year: 2004
    ..The results will be important for immunodeficient humans chronically infected with the parasite. ..
  34. HOST IMMUNOREGULATION OF ANTILEISHMANIAL CHEMOTHERAPY
    Henry Murray; Fiscal Year: 2005
    ..And Aim 3: Characterize immunostimulation in AmB's efficacy, and in recrudescent infection following AmB therapy, pinpoint the likely cytokine-driven T cell mechanism which prevents post-treatment relapse. ..
  35. Manipulation of T cell tolerance with small organic mol*
    Anjana Rao; Fiscal Year: 2005
    ..The hope is that the 'information obtained from this pilot R21 proposal will eventually be extended to whole animal models of transplant and tumour rejection, allergy and autoimmune disease. ..
  36. Protective role of cross-reactive anti-enteric antibody
    Lynn Bry; Fiscal Year: 2005
    ....
  37. Heavy Metal-Induced Autoimmunity
    DWIGHT KONO; Fiscal Year: 2005
    ....
  38. Immunogenetics of Leishmania chagasi Infection
    Mary Wilson; Fiscal Year: 2005
    ..chagasi infection, and to identify specific alleles that influence human immune responses and thereby modify the course of disease. ..
  39. Modulation of EAE with ligand-activated NKT cells
    Luc Van Kaer; Fiscal Year: 2005
    ..These reagents will permit the selective activation of distinct adaptive immune responses in vivo, which could be exploited for therapeutic intervention in MS and other human autoimmune diseases. ..
  40. TUMOR NECROSIS FACTOR INVOLVEMENT IN FUMONISIN TOXICITY
    RAGHUBIR SHARMA; Fiscal Year: 2001
    ..Results will help in defining the mechanism(s) of fumonisin toxicity, causes of species-specificity, and provide a better appraisal of risk in humans, including modification of fumonisin response by gram-negative infections. ..
  41. Mechanisms of liver disease in a mouse model of AIH
    JAMES GORHAM; Fiscal Year: 2006
    ..The final aim is to analyze the genetics, mechanisms, and specificity of hepatic BALB/c-TGF-b1(-/-) effector cytotoxic T lymphocytes. ..
  42. FLOW CYTOMETRY INSTRUMENT
    ZUHAIR BALLAS; Fiscal Year: 2001
    ..abstract_text> ..
  43. Modulation of type I diabetes with NKT cells
    Luc Van Kaer; Fiscal Year: 2006
    ..These studies will provide a better understanding of the immunological mechanisms that result in autoimmunity, and may lead to the development of novel agents for treatment of type I diabetes and other autoimmune diseases. ..
  44. A novel inbred mouse model of autoimmune hepatitis
    JAMES GORHAM; Fiscal Year: 2002
    ..The proposal seeks to understand mechanisms that regulate the development of inflammation in the liver, so as to gain insights into the pathogenic mechanisms of AIH and other hepatic inflammatory diseases. ..
  45. Mechanisms of IVIG Protection in Viral Encephalitis
    EDOUARD M CANTIN; Fiscal Year: 2010
    ..Results from these studies will be important for making the case for IVIG as a treatment for neuroinflammatory diseases including encephalitis caused by HSV and other viruses like West Nile virus that are potential bioterrorism agents. ..
  46. TUMOR ASSOCIATED DENDRITIC CELLS
    Michael Shurin; Fiscal Year: 2002
    ....
  47. Tumor-induced immune suppression.
    Suzanne Ostrand Rosenberg; Fiscal Year: 2010
    ..abstract_text> ..
  48. T cell Function in Murine Model of Multiple Sclerosis
    Moses Rodriguez; Fiscal Year: 2010
    ..The findings are expected to provide new insights into the pathogenesis of axonal and neuronal injury in demyelinating disorders such as multiple sclerosis. ..
  49. Crimson - i2b2 integration for high-throughput, scalable sample collection
    Lynn Bry; Fiscal Year: 2010
    ....
  50. Development of Cellular Assays of Dengue Virus Infection
    Priscilla Yang; Fiscal Year: 2008
    ..These inhibitors can be used to study how dengue virus interacts with its host, and they may also be useful in developing therapies for the treatment of dengue virus infections. [unreadable] [unreadable] [unreadable]..
  51. Roles of CD40 and CD40 Ligand in Allograft Rejection
    D Bishop; Fiscal Year: 2008
    ..Identifying the mechanisms by which CD40 and CD40L contribute to rejection should facilitate development of therapies that target this critical pathway in transplant rejection. ..
  52. Defending Against Systemic Mycoses
    GEORGE DEEPE; Fiscal Year: 2008
    ..The collaborative and synergistic effort manifested by this group of investigators will provide new and exciting information regarding prevention and/or treatment of these problematic fungi. ..
  53. Host Immunoregulation of Response to Antileishmanial Chemotherapy
    Henry Murray; Fiscal Year: 2007
    ..abstract_text> ..
  54. Role of Galectin-4 in Colitis
    Atsushi Mizoguchi; Fiscal Year: 2008
    ..These studies will not only enhance understanding of the pathogenic mechanisms of IBD but also provide important information to develop new therapeutic approaches for human IBD. ..
  55. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
    ..abstract_text> ..
  56. Monocyte Biology and Biodefense
    DOUGLAS DREVETS; Fiscal Year: 2005
    ..These data will then catalyze development of rational therapies to improve host defenses against severe and overwhelming infection by category A and B intracellular bacterial pathogens. ..
  57. T CELL CONTROL OF AIRWAY MUCUS PRODUCTION
    Lauren Cohn; Fiscal Year: 2009
    ..AIM II. Determine the mechanism of IFN-g inhibition of eosinophilia and its relationship to the reciprocal induction of neutrophilia. AIM III. Determine how IFN-g regulates the number of Th2 cells in the respiratory tract. ..
  58. Tumor cell antigen presentation to CD4 + T lymphocytes
    Suzanne Ostrand Rosenberg; Fiscal Year: 2004
    ..of anti-tumor immunity? Which effector cells, cytokines, and chemokines are induced during therapy? 5) Does tumor burden correlate with tumor-induced immuno-suppression? Does surgical removal of primary tumor reverse mmuno-suppression? ..